{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T17:10:14Z","timestamp":1769015414466,"version":"3.49.0"},"reference-count":161,"publisher":"Elsevier","isbn-type":[{"value":"9780443470943","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.acc.2025.10.012","type":"book-chapter","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T10:11:19Z","timestamp":1763633479000},"page":"133-174","source":"Crossref","is-referenced-by-count":0,"title":["Endocrine disruption in metabolic disorders: Biomarkers and therapeutic targets"],"prefix":"10.1016","member":"78","reference":[{"issue":"6","key":"10.1016\/bs.acc.2025.10.012_bib1","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1210\/er.2015-1010","article-title":"EDC-2: the Endocrine Society\u2019s second scientific statement on endocrine-disrupting chemicals","volume":"36","author":"Gore","year":"2015","journal-title":"Endocr. Rev."},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: an endocrine society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr. Rev."},{"key":"10.1016\/bs.acc.2025.10.012_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.reprotox.2016.10.001","article-title":"Metabolism disrupting chemicals and metabolic disorders","volume":"68","author":"Heindel","year":"2017","journal-title":"Reprod. Toxicol."},{"issue":"9","key":"10.1016\/bs.acc.2025.10.012_bib4","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/nrendo.2017.51","article-title":"Endocrine-disrupting chemicals and the regulation of energy balance","volume":"13","author":"Nadal","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"issue":"5","key":"10.1016\/bs.acc.2025.10.012_bib5","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ajog.2016.01.182","article-title":"Obesogens: an emerging threat to public health","volume":"214","author":"Janesick","year":"2016","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.mce.2011.09.005","article-title":"Thyroid effects of endocrine disrupting chemicals","volume":"355","author":"Boas","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"issue":"11","key":"10.1016\/bs.acc.2025.10.012_bib7","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nrendo.2015.163","article-title":"Endocrine disruptors and obesity","volume":"11","author":"Heindel","year":"2015","journal-title":"Nat. Rev. Endocrinol"},{"issue":"9","key":"10.1016\/bs.acc.2025.10.012_bib8","doi-asserted-by":"crossref","first-page":"4097","DOI":"10.1210\/en.2012-1422","article-title":"Endocrine-disrupting chemicals and public health protection: a statement of principles from the endocrine society","volume":"153","author":"Zoeller","year":"2012","journal-title":"Endocrinology"},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/andr.12178","article-title":"Burden of disease and costs of exposure to endocrine disrupting chemicals in the E uropean U nion: an updated analysis","volume":"4","author":"Trasande","year":"2016","journal-title":"Andrology"},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41574-019-0273-8","article-title":"Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification","volume":"16","author":"La Merrill","year":"2020","journal-title":"Nat. Rev. Endocrinol"},{"issue":"8","key":"10.1016\/bs.acc.2025.10.012_bib11","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.3390\/ijms21083021","article-title":"The EDCMET project: Metabolic effects of endocrine disruptors","volume":"21","author":"K\u00fcblbeck","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/bs.acc.2025.10.012_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2023.163991","article-title":"Dietary exposure to endocrine disruptors in gut microbiota: a systematic review","volume":"886","author":"Calero-Medina","year":"2023","journal-title":"Sci. Total. Environ."},{"key":"10.1016\/bs.acc.2025.10.012_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.757088","article-title":"Plasma metabolomics reveals metabolic profiling for diabetic retinopathy and disease progression","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"11","key":"10.1016\/bs.acc.2025.10.012_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111930","article-title":"A metabolic profiling strategy for the dissection of plant defense against fungal pathogens","volume":"9","author":"Aliferis","year":"2014","journal-title":"PLoS ONE"},{"issue":"8","key":"10.1016\/bs.acc.2025.10.012_bib15","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.2337\/db12-0754","article-title":"Metabolite profiles during oral glucose challenge","volume":"62","author":"Ho","year":"2013","journal-title":"Diabetes"},{"issue":"7","key":"10.1016\/bs.acc.2025.10.012_bib16","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1021\/acschembio.5b00053","article-title":"Activity-based protein profiling of oncogene-driven changes in metabolism reveals broad dysregulation of PAFAH1B2 and 1B3 in cancer","volume":"10","author":"Kohnz","year":"2015","journal-title":"ACS Chem. Biol."},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib17","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1017\/S0029665116000288","article-title":"Circadian regulation of lipid metabolism","volume":"75","author":"Gooley","year":"2016","journal-title":"Proc. Nutr. Soc."},{"key":"10.1016\/bs.acc.2025.10.012_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2019.154735","article-title":"Leptin as a predictive marker for metabolic syndrome","volume":"121","author":"Ghadge","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/bs.acc.2025.10.012_bib19","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fendo.2016.00138","article-title":"Possible integrative actions of leptin and insulin signaling in the hypothalamus targeting energy homeostasis","volume":"7","author":"Thon","year":"2016","journal-title":"Front. Endocrinol"},{"issue":"9","key":"10.1016\/bs.acc.2025.10.012_bib20","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.3390\/biomedicines11092589","article-title":"The interplay of adipokines and pancreatic beta cells in metabolic regulation and diabetes","volume":"11","author":"Kim","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/bs.acc.2025.10.012_bib21","first-page":"13","article-title":"Regulation of nutrient metabolism and inflammation","author":"Kersten","year":"2010","journal-title":"Sens. Metab. Control. Energy Balance"},{"issue":"3","key":"10.1016\/bs.acc.2025.10.012_bib22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1530\/eje.0.1430293","article-title":"Human leptin: from an adipocyte hormone to an endocrine mediator","volume":"143","author":"Wauters","year":"2000","journal-title":"Eur. J. Endocrinol."},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/endrev\/bnaa027","article-title":"Tissue-specific effects of leptin on glucose and lipid metabolism","volume":"42","author":"Pereira","year":"2021","journal-title":"Endocr. Rev."},{"key":"10.1016\/bs.acc.2025.10.012_bib24","doi-asserted-by":"crossref","first-page":"191","DOI":"10.2147\/IJGM.S102230","article-title":"Overview of air pollution and endocrine disorders","author":"Darbre","year":"2018","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/bs.acc.2025.10.012_bib25","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.mce.2017.02.045","article-title":"Recent advances on bisphenol-a and endocrine disruptor effects on human prostate cancer","volume":"457","author":"Di Donato","year":"2017","journal-title":"Mol. Cell. Endocrinol"},{"issue":"3-5","key":"10.1016\/bs.acc.2025.10.012_bib26","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jsbmb.2011.08.007","article-title":"Endocrine disrupting chemicals and disease susceptibility","volume":"127","author":"Schug","year":"2011","journal-title":"J. steroid Biochem. Mol. Biol"},{"key":"10.1016\/bs.acc.2025.10.012_bib27","series-title":"Environmental health risk-hazardous factors to living species","first-page":"155","article-title":"Environmental effects of endocrine-disrupting chemicals: a special focus on phthalates and bisphenol A","author":"Erkekoglu","year":"2016"},{"key":"10.1016\/bs.acc.2025.10.012_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2022.107550","article-title":"Groundwater contamination pathways of phthalates and bisphenol A: origin, characteristics, transport, and fate\u2013a review","volume":"170","author":"Due\u00f1as-Moreno","year":"2022","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/14647273.2017.1358828","article-title":"Exposure to modern, widespread environmental endocrine disrupting chemicals and their effect on the reproductive potential of women: an overview of current epidemiological evidence","volume":"22","author":"Karwacka","year":"2019","journal-title":"Hum. Fertil"},{"key":"10.1016\/bs.acc.2025.10.012_bib30","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1007\/s12020-016-1158-4","article-title":"The influence of phthalates and bisphenol a on the obesity development and glucose metabolism disorders","volume":"55","author":"Stojanoska","year":"2017","journal-title":"Endocrine"},{"key":"10.1016\/bs.acc.2025.10.012_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2022.113201","article-title":"Bisphenol F suppresses insulin-stimulated glucose metabolism in adipocytes by inhibiting IRS-1\/PI3K\/AKT pathway","volume":"231","author":"Chen","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib32","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1289\/ehp.8451","article-title":"The estrogenic effect of bisphenol a disrupts pancreatic \u03b2-cell function in vivo and induces insulin resistance","volume":"114","author":"Alonso-Magdalena","year":"2006","journal-title":"Environ. Health Perspect"},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib33","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1365-2605.2007.00832.x","article-title":"Bisphenol\u2010A disruption of the endocrine pancreas and blood glucose homeostasis","volume":"31","author":"Ropero","year":"2008","journal-title":"Int. J. Androl."},{"key":"10.1016\/bs.acc.2025.10.012_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2020.103373","article-title":"Bisphenol A-induced metabolic disorders: from exposure to mechanism of action","volume":"77","author":"Akash","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/bs.acc.2025.10.012_bib35","article-title":"Chronic exposure of bisphenol A impairs carbohydrate and lipid metabolism by altering corresponding enzymatic and metabolic pathways","volume":"78","author":"Ul Haq","year":"2020","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"10","key":"10.1016\/bs.acc.2025.10.012_bib36","article-title":"The hidden threat: Endocrine disruptors and their impact on insulin resistance","volume":"15","author":"Dagar","year":"2023","journal-title":"Cureus"},{"key":"10.1016\/bs.acc.2025.10.012_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhep.2023.08.030","article-title":"Endocrine aspects of metabolic dysfunction associated steatotic liver disease (MASLD): Beyond insulin resistance","author":"Hutchison","year":"2023","journal-title":"J. Hepatol."},{"issue":"15","key":"10.1016\/bs.acc.2025.10.012_bib38","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.3390\/nu15153483","article-title":"Glycemic index and glycemic load estimates in the dietary approach of polycystic ovary syndrome","volume":"15","author":"Manta","year":"2023","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/bs.acc.2025.10.012_bib39","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2188\/jea.JE20150183","article-title":"Investigation of the relationship between chronic stress and insulin resistance in a Chinese population","volume":"26","author":"Yan","year":"2016","journal-title":"J. Epidemiol."},{"key":"10.1016\/bs.acc.2025.10.012_bib40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12011-018-1629-y","article-title":"Association between cortisol, insulin resistance and zinc in obesity: a mini-review","volume":"191","author":"Morais","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"issue":"3","key":"10.1016\/bs.acc.2025.10.012_bib41","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3109\/15622970109026799","article-title":"Stress hormone-related psychopathology: pathophysiological and treatment implications","volume":"2","author":"Wolkowitz","year":"2001","journal-title":"World J. Biol. Psychiatry"},{"issue":"6","key":"10.1016\/bs.acc.2025.10.012_bib42","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.coph.2006.08.002","article-title":"Role of adipokines in the control of energy metabolism: focus on adiponectin","volume":"6","author":"Lafontan","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"issue":"9","key":"10.1016\/bs.acc.2025.10.012_bib43","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1373\/clinchem.2004.032482","article-title":"Endocrine regulation of energy metabolism: review of pathobiochemical and clinical chemical aspects of leptin, ghrelin, adiponectin, and resistin","volume":"50","author":"Meier","year":"2004","journal-title":"Clin. Chem."},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib44","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2174\/1389450054021972","article-title":"Adipokines: therapeutic targets for metabolic syndrome","volume":"6","author":"Kobayashi","year":"2005","journal-title":"Curr. Drug. Targets"},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib45","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/nrrheum.2016.209","article-title":"Leptin in the interplay of inflammation, metabolism and immune system disorders","volume":"13","author":"Abella","year":"2017","journal-title":"Nat. Rev. Rheumatol"},{"issue":"3","key":"10.1016\/bs.acc.2025.10.012_bib46","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s11892-003-0065-2","article-title":"Adiponectin: systemic contributor to insulin sensitivity","volume":"3","author":"Pajvani","year":"2003","journal-title":"Curr. Diabetes Rep."},{"issue":"5","key":"10.1016\/bs.acc.2025.10.012_bib47","doi-asserted-by":"crossref","first-page":"E1335","DOI":"10.1152\/ajpendo.00333.2007","article-title":"Secretion of neuropeptide Y in human adipose tissue and its role in maintenance of adipose tissue mass","volume":"293","author":"Kos","year":"2007","journal-title":"Am. J. Physiol.-Endocrinol.\u00a0Metab."},{"key":"10.1016\/bs.acc.2025.10.012_bib48","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/s00335-014-9538-7","article-title":"The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis","volume":"25","author":"Cantley","year":"2014","journal-title":"Mammalian Genome"},{"key":"10.1016\/bs.acc.2025.10.012_bib49","article-title":"Endothelial function and dysfunction: impact of sodium-glucose cotransporter 2 inhibitors","volume":"224","author":"Ugusman","year":"2021","journal-title":"Pharmacol.\u00a0Ther."},{"issue":"7","key":"10.1016\/bs.acc.2025.10.012_bib50","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1093\/cvr\/cvab080","article-title":"New aspects of endocrine control of atrial fibrillation and possibilities for clinical translation","volume":"117","author":"Aguilar","year":"2021","journal-title":"Cardiovasc. Res."},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib51","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/cpt.274","article-title":"Drug\u2010induced diabetes mellitus: evidence for statins and other drugs affecting glucose metabolism","volume":"99","author":"Anyanwagu","year":"2016","journal-title":"Clin. Pharmacol.\u00a0Ther."},{"issue":"12","key":"10.1016\/bs.acc.2025.10.012_bib52","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.3390\/biom11121834","article-title":"Effects of metformin in heart failure: from pathophysiological rationale to clinical evidence","volume":"11","author":"Salvatore","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib53","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1373\/clinchem.2017.275172","article-title":"Addressing the perfect storm: biomarkers in obesity and pathophysiology of cardiometabolic risk","volume":"64","author":"Aleksandrova","year":"2018","journal-title":"Clin. Chem"},{"issue":"5","key":"10.1016\/bs.acc.2025.10.012_bib54","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.clnu.2018.09.024","article-title":"Circulating microRNAs and adipokines as markers of metabolic syndrome in adolescents with obesity","volume":"38","author":"Al-Rawaf","year":"2019","journal-title":"Clin. Nutr"},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib55","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1161\/CIRCRESAHA.120.314458","article-title":"Adiponectin, leptin and cardiovascular disorders","volume":"128","author":"Zhao","year":"2021","journal-title":"Circulation Res."},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib56","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3892\/etm.2012.557","article-title":"Relationship between adipocytokines and cardiovascular risk factors in patients with type 2 diabetes mellitus","volume":"4","author":"Uslu","year":"2012","journal-title":"Exp. Therapeutic Med."},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib57","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1530\/EJE-09-0555","article-title":"Resistin is associated with biomarkers of inflammation while total and high-molecular weight adiponectin are associated with biomarkers of inflammation, insulin resistance, and endothelial function","volume":"162","author":"Fargnoli","year":"2010","journal-title":"Eur. J. Endocrinol."},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib58","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/MCP.0b013e32819f8f06","article-title":"Biomarkers for lung cancer: clinical uses","volume":"13","author":"Greenberg","year":"2007","journal-title":"Curr. Opin. Pulmonary Med."},{"issue":"11","key":"10.1016\/bs.acc.2025.10.012_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2023.101922","article-title":"Smart technologies used as smart tools in the management of cardiovascular disease and their future perspective","volume":"48","author":"Ullah","year":"2023","journal-title":"Curr. Probl. Cardiol."},{"issue":"24","key":"10.1016\/bs.acc.2025.10.012_bib60","doi-asserted-by":"crossref","first-page":"6094","DOI":"10.3390\/cancers14246094","article-title":"Biomarkers for the detection and risk stratification of aggressive prostate cancer","volume":"14","author":"Eickelschulte","year":"2022","journal-title":"Cancers"},{"issue":"_5","key":"10.1016\/bs.acc.2025.10.012_bib61","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1093\/europace\/eup304","article-title":"Heart failure burden and therapy","volume":"11","author":"Zannad","year":"2009","journal-title":"Europace"},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib62","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.pcad.2012.06.004","article-title":"Translating metabolomics to cardiovascular biomarkers","volume":"55","author":"Senn","year":"2012","journal-title":"Prog. Cardiovasc.\u00a0Dis."},{"issue":"12","key":"10.1016\/bs.acc.2025.10.012_bib63","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3390\/metabo9120301","article-title":"Emerging insights into the metabolic alterations in aging using metabolomics","volume":"9","author":"Srivastava","year":"2019","journal-title":"Metabolites"},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib64","doi-asserted-by":"crossref","first-page":"17666","DOI":"10.1038\/s41598-023-41176-4","article-title":"Combined metabolomic and lipidomic analysis uncovers metabolic profile and biomarkers for papillary thyroid carcinoma","volume":"13","author":"Wang","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.acc.2025.10.012_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2023.103751","article-title":"Metabolomics and lipidomics strategies in modern drug discovery and development","author":"Astarita","year":"2023","journal-title":"Drug. Discovery Today"},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib66","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jacc.2008.03.043","article-title":"Application of metabolomics to cardiovascular biomarker and pathway discovery","volume":"52","author":"Lewis","year":"2008","journal-title":"J. Am. Coll. Cardiol."},{"issue":"12","key":"10.1016\/bs.acc.2025.10.012_bib67","doi-asserted-by":"crossref","first-page":"2000052","DOI":"10.1002\/bies.202000052","article-title":"Metabolomics meets lipidomics: assessing the small molecule component of metabolism","volume":"42","author":"Gallart\u2010Ayala","year":"2020","journal-title":"BioEssays"},{"key":"10.1016\/bs.acc.2025.10.012_bib68","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.prostaglandins.2016.12.002","article-title":"Recent advances in lipidomics: analytical and clinical perspectives","volume":"128","author":"Sethi","year":"2017","journal-title":"Prostaglandins Other Lipid Mediat."},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib69","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2217\/bmm.14.81","article-title":"Lipidomics applications for disease biomarker discovery in mammal models","volume":"9","author":"Zhao","year":"2015","journal-title":"Biomarkers Med."},{"key":"10.1016\/bs.acc.2025.10.012_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2021.114048","article-title":"Serum lipid profiling analysis and potential marker discovery for ovarian cancer based on liquid chromatography\u2013Mass spectrometry","volume":"199","author":"Wang","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib71","doi-asserted-by":"crossref","DOI":"10.1002\/rcm.9670","article-title":"Liquid chromatography\u2013mass spectrometry\u2010based metabolomics and fluxomics reveals the metabolic alterations in glioma U87MG multicellular tumor spheroids versus two\u2010dimensional cell cultures","volume":"38","author":"Wen","year":"2024","journal-title":"Rapid Commun. Mass. Spectrometry"},{"key":"10.1016\/bs.acc.2025.10.012_bib72","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1007\/s10545-017-0114-7","article-title":"Plasma lipidomics as a diagnostic tool for peroxisomal disorders","volume":"41","author":"Herzog","year":"2018","journal-title":"J. Inherit. Metab. Dis."},{"issue":"5","key":"10.1016\/bs.acc.2025.10.012_bib73","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.144392","article-title":"Proteomic profiling reveals biomarkers and pathways in type 2 diabetes risk","volume":"6","author":"Ngo","year":"2021","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib74","doi-asserted-by":"crossref","first-page":"159","DOI":"10.3390\/biomedicines9020159","article-title":"Proteomic profiling and artificial intelligence for hepatocellular carcinoma translational medicine","volume":"9","author":"Moldogazieva","year":"2021","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib75","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2217\/17520363.1.1.159","article-title":"Future of liquid chromatography\u2013mass spectrometry in metabolic profiling and metabolomic studies for biomarker discovery","volume":"1","author":"Metz","year":"2007","journal-title":"Biomarkers Med."},{"issue":"3","key":"10.1016\/bs.acc.2025.10.012_bib76","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1111\/1541-4337.12938","article-title":"Untargeted metabolomics by liquid chromatography\u2010mass spectrometry for food authentication: a review","volume":"21","author":"Zhong","year":"2022","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib77","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/mas.21455","article-title":"Mass spectrometric based approaches in urine metabolomics and biomarker discovery","volume":"36","author":"Khamis","year":"2017","journal-title":"Mass. Spectrometry Rev."},{"key":"10.1016\/bs.acc.2025.10.012_bib78","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-1-4939-7643-0_9","article-title":"Untargeted GC-MS Metabolomics","author":"Papadimitropoulos","year":"2018","journal-title":"Metab. Profiling: Methods Protoc."},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib79","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3390\/metabo10040143","article-title":"Metabolomics benefits from orbitrap GC\u2013MS\u2014comparison of low-and high-resolution GC\u2013MS","volume":"10","author":"Stettin","year":"2020","journal-title":"Metabolites"},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib80","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/metabo7020025","article-title":"Breast tissue metabolism by magnetic resonance spectroscopy","volume":"7","author":"Jagannathan","year":"2017","journal-title":"Metabolites"},{"issue":"5","key":"10.1016\/bs.acc.2025.10.012_bib81","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3390\/metabo13050614","article-title":"Benchtop NMR-based metabolomics: First steps for biomedical application","volume":"13","author":"Alonso-Moreno","year":"2023","journal-title":"Metabolites"},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib82","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/TA.0b013e3181e043fe","article-title":"1H NMR-based metabolic signatures of clinical outcomes in trauma patients\u2014beyond lactate and base deficit","volume":"69","author":"Cohen","year":"2010","journal-title":"J. Trauma. Acute Care Surg."},{"issue":"16-18","key":"10.1016\/bs.acc.2025.10.012_bib83","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1016\/j.phytochem.2007.04.011","article-title":"Towards dynamic metabolic network measurements by multi-dimensional NMR-based fluxomics","volume":"68","author":"Sekiyama","year":"2007","journal-title":"Phytochemistry"},{"key":"10.1016\/bs.acc.2025.10.012_bib84","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.procbio.2020.08.023","article-title":"1H NMR-based metabolomics for cancer targeting and metabolic engineering\u2013A review","volume":"99","author":"Raja","year":"2020","journal-title":"Process. Biochem."},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib85","doi-asserted-by":"crossref","first-page":"53","DOI":"10.55544\/jrasb.2.2.9","article-title":"A comprehensive review on analytical method development using rp-hplc and recent advances in pharmaceutical applications","volume":"2","author":"Kumar","year":"2023","journal-title":"J. Res. Appl. Sci. Biotechnol."},{"key":"10.1016\/bs.acc.2025.10.012_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2022.123482","article-title":"LC-MS\/MS based detection of circulating proinsulin derived peptides in patients with altered pancreatic beta cell function","volume":"1211","author":"Foreman","year":"2022","journal-title":"J. Chromatogr. B"},{"issue":"5","key":"10.1016\/bs.acc.2025.10.012_bib87","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1515\/cclm-2022-0942","article-title":"Determination of parathyroid hormone: from radioimmunoassay to LCMS\/MS","volume":"61","author":"Cavalier","year":"2023","journal-title":"Clin. Chem. Laboratory Med. (CCLM)"},{"key":"10.1016\/bs.acc.2025.10.012_bib88","series-title":"Methods in enzymology","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0076-6879(87)43018-8","article-title":"High-performance liquid chromatography of thiols and disulfides: dinitrophenol derivatives","author":"Fariss","year":"1987"},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib89","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1021\/acs.iecr.6b03814","article-title":"Separation of glutathionate-protected gold clusters by reversed-phase ion-pair high-performance liquid chromatography","volume":"56","author":"Niihori","year":"2017","journal-title":"Ind. & Eng. Chem. Res."},{"key":"10.1016\/bs.acc.2025.10.012_bib90","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0021-9673(01)88216-9","article-title":"Reversed-phase C18 high-performance liquid chromatography of acidic and conjugated gibberellins","volume":"256","author":"Koshioka","year":"1983","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/bs.acc.2025.10.012_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114029","article-title":"Insulin quantification towards early diagnosis of prediabetes\/diabetes","volume":"203","author":"Lian","year":"2022","journal-title":"Biosens. Bioelectron"},{"issue":"9","key":"10.1016\/bs.acc.2025.10.012_bib92","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/jid.2013.287","article-title":"Enzyme immunoassay and enzyme-linked immunosorbent assay","volume":"133","author":"Gan","year":"2013","journal-title":"J. Investig. Dermatol."},{"key":"10.1016\/bs.acc.2025.10.012_bib93","article-title":"Harnessing bioluminescent bacteria to develop an enzymatic-free enzyme-linked immunosorbent assay for the detection of clinically relevant biomarkers","author":"Hu","year":"2024","journal-title":"ACS Appl. Mater. & Interfaces"},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib94","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.domaniend.2011.05.001","article-title":"Evaluation of commercially available assays for the measurement of equine insulin","volume":"41","author":"Tinworth","year":"2011","journal-title":"Domestic Anim. Endocrinol."},{"key":"10.1016\/bs.acc.2025.10.012_bib95","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12917-016-0828-z","article-title":"Comparison of three different methods for the quantification of equine insulin","volume":"12","author":"Warnken","year":"2016","journal-title":"BMC Veterinary Res."},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib96","doi-asserted-by":"crossref","first-page":"498","DOI":"10.2337\/diacare.18.4.498","article-title":"Immunogenicity of long-term intraperitoneal insulin administration with implantable programmable pumps: metabolic consequences","volume":"18","author":"Lassmann-Vague","year":"1995","journal-title":"Diabetes Care"},{"issue":"7","key":"10.1016\/bs.acc.2025.10.012_bib97","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.metabol.2004.02.009","article-title":"Relationships between serum soluble leptin receptor level and serum leptin and adiponectin levels, insulin resistance index, lipid profile, and leptin receptor gene polymorphisms in the Japanese population","volume":"53","author":"Ogawa","year":"2004","journal-title":"Metabolism"},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib98","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1359\/JBMR.040107","article-title":"Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women","volume":"19","author":"Kontogianni","year":"2004","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/bs.acc.2025.10.012_bib99","doi-asserted-by":"crossref","DOI":"10.1053\/j.seminoncol.2016.10.003","article-title":"Genetic predisposition to leukemia and other hematologic malignancies","author":"Feurstein","year":"2016","journal-title":"Semin. Oncol"},{"issue":"2-3","key":"10.1016\/bs.acc.2025.10.012_bib100","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ymgme.2015.05.002","article-title":"Next generation sequencing in endocrine practice","volume":"115","author":"Forlenza","year":"2015","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/bs.acc.2025.10.012_bib101","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s00401-015-1519-8","article-title":"Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets","volume":"131","author":"Sahm","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"5","key":"10.1016\/bs.acc.2025.10.012_bib102","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.fertnstert.2012.12.018","article-title":"Evaluation of targeted next-generation sequencing\u2013based preimplantation genetic diagnosis of monogenic disease","volume":"99","author":"Treff","year":"2013","journal-title":"Fertil. Steril"},{"issue":"6","key":"10.1016\/bs.acc.2025.10.012_bib103","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1399-0004.2012.01865.x","article-title":"Next\u2010generation sequencing: ready for the clinics?","volume":"81","author":"Desai","year":"2012","journal-title":"Clin. Genet."},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib104","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.tips.2020.12.005","article-title":"Biased allosteric modulators: new frontiers in GPCR drug discovery","volume":"42","author":"Slosky","year":"2021","journal-title":"Trends Pharmacol. Sci."},{"issue":"17","key":"10.1016\/bs.acc.2025.10.012_bib105","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.3390\/ijms20174237","article-title":"Recent insights from molecular dynamics simulations for g protein-coupled receptor drug discovery","volume":"20","author":"Zou","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"11","key":"10.1016\/bs.acc.2025.10.012_bib106","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1038\/nbt.3028","article-title":"Allosteric targeting of receptor tyrosine kinases","volume":"32","author":"De Smet","year":"2014","journal-title":"Nat. Biotechnol."},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib107","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1747-0285.2010.00946.x","article-title":"Riboflavin biosynthetic and regulatory factors as potential novel anti\u2010infective drug targets","volume":"75","author":"Long","year":"2010","journal-title":"Chem. Biol. & drug. Des."},{"issue":"9","key":"10.1016\/bs.acc.2025.10.012_bib108","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.tem.2016.03.011","article-title":"SCFA receptors in pancreatic \u03b2 cells: Novel diabetes targets?","volume":"27","author":"Priyadarshini","year":"2016","journal-title":"Trends Endocrinol. & Metab"},{"issue":"6","key":"10.1016\/bs.acc.2025.10.012_bib109","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1177\/2472555216683937","article-title":"A small-molecule microarray approach for the identification of E2 enzyme inhibitors in ubiquitin-like conjugation pathways","volume":"22","author":"Zlotkowski","year":"2017","journal-title":"SLAS Discovery: Advancing Life Sci. R&D"},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/JME-08-0132","article-title":"Endocrine disruptive chemicals: Mechanisms of action and involvement in metabolic disorders","volume":"43","author":"Swedenborg","year":"2009","journal-title":"J. Mol. Endocrinol."},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib111","article-title":"Endothelial dysfunction in pregnancy metabolic disorders","volume":"1866","author":"Echeverria","year":"2020","journal-title":"Biochimica et. Biophysica Acta (BBA)-Molecular Basis Dis."},{"issue":"12","key":"10.1016\/bs.acc.2025.10.012_bib112","doi-asserted-by":"crossref","first-page":"550","DOI":"10.3390\/biomedicines8120550","article-title":"Molecular and cellular mechanisms of electronegative lipoproteins in cardiovascular diseases","volume":"8","author":"Ke","year":"2020","journal-title":"Biomedicines"},{"key":"10.1016\/bs.acc.2025.10.012_bib113","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.3389\/fimmu.2017.01882","article-title":"Gut microbiota dysbiosis drives and implies novel therapeutic strategies for diabetes mellitus and related metabolic diseases","volume":"8","author":"Li","year":"2017","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/bs.acc.2025.10.012_bib114","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00403-022-02395-3","article-title":"Flavonoids and their therapeutic applications in skin diseases","volume":"315","author":"Ma","year":"2023","journal-title":"Arch. Dermatol.\u00a0Res."},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib115","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2174\/0929867321666140826115422","article-title":"Polyphenols-rich natural products for treatment of diabetes","volume":"22","author":"Dragan","year":"2015","journal-title":"Curr. Medicinal Chem."},{"key":"10.1016\/bs.acc.2025.10.012_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106498","article-title":"Natural compounds flavonoids as modulators of inflammasomes in chronic diseases","volume":"84","author":"Owona","year":"2020","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib117","first-page":"6713194","article-title":"The bioprotective effects of polyphenols on metabolic syndrome against oxidative stress: evidences and perspectives","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"10","key":"10.1016\/bs.acc.2025.10.012_bib118","doi-asserted-by":"crossref","first-page":"3286","DOI":"10.3390\/molecules27103286","article-title":"Chemical compounds of berry-derived polyphenols and their effects on gut microbiota, inflammation, and cancer","volume":"27","author":"Bouyahya","year":"2022","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib119","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s00253-022-11801-9","article-title":"Inhibitory activities of grape bioactive compounds against enzymes linked with human diseases","volume":"106","author":"Dwibedi","year":"2022","journal-title":"Appl. Microbiology Biotechnol."},{"issue":"5","key":"10.1016\/bs.acc.2025.10.012_bib120","first-page":"235","article-title":"From research to daily clinical practice: what are the challenges in \u201ctranslation\u201d?","volume":"30","author":"Feifer","year":"2004","journal-title":"Jt. Comm. J. Qual. Saf."},{"key":"10.1016\/bs.acc.2025.10.012_bib121","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-1-4939-3584-0_6","article-title":"Mesenchymal stem cells in Lipogems, a reverse story: from clinical practice to basic science","author":"Tremolada","year":"2016","journal-title":"Mesenchymal Stem Cells: Methods Protoc"},{"issue":"160","key":"10.1016\/bs.acc.2025.10.012_bib122","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002717","article-title":"Designing regenerative biomaterial therapies for the clinic","volume":"4","author":"Pashuck","year":"2012","journal-title":"Sci. Transl. Med."},{"issue":"10","key":"10.1016\/bs.acc.2025.10.012_bib123","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1377\/hlthaff.2010.0696","article-title":"Bench to behavior\u2019: translating comparative effectiveness research into improved clinical practice","volume":"29","author":"Avorn","year":"2010","journal-title":"Health Aff."},{"issue":"5-6","key":"10.1016\/bs.acc.2025.10.012_bib124","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/jocn.13586","article-title":"Translating research findings to clinical nursing practice","volume":"26","author":"Curtis","year":"2017","journal-title":"J. Clin. Nurs"},{"issue":"6","key":"10.1016\/bs.acc.2025.10.012_bib125","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1093\/bib\/bbx170","article-title":"Metabolomics technology and bioinformatics for precision medicine","volume":"20","author":"Azad","year":"2019","journal-title":"Brief. Bioinforma"},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib126","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1042\/ETLS20210244","article-title":"Multi-omics strategies for personalized and predictive medicine: past, current, and future translational opportunities","volume":"6","author":"Ahmed","year":"2022","journal-title":"Emerg. Top. life Sci."},{"issue":"12","key":"10.1016\/bs.acc.2025.10.012_bib127","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1161\/CIRCRESAHA.123.322135","article-title":"Epigenetics of early cardiometabolic disease: mechanisms and precision medicine","volume":"132","author":"Baccarelli","year":"2023","journal-title":"Circulation Res."},{"key":"10.1016\/bs.acc.2025.10.012_bib128","doi-asserted-by":"crossref","first-page":"1065506","DOI":"10.3389\/fmedt.2022.1065506","article-title":"Metabolomics in hepatocellular carcinoma: from biomarker discovery to precision medicine","volume":"4","author":"Wu","year":"2023","journal-title":"Front. Med. Technol."},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib129","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1515\/hsz-2019-0268","article-title":"Bioenergetics and translational metabolism: implications for genetics, physiology and precision medicine","volume":"401","author":"Hill","year":"2019","journal-title":"Biol. Chem."},{"issue":"2","key":"10.1016\/bs.acc.2025.10.012_bib130","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3233\/CBM-210301","article-title":"Applications of artificial intelligence (AI) in ovarian cancer, pancreatic cancer, and image biomarker discovery","volume":"33","author":"Mikdadi","year":"2022","journal-title":"Cancer Biomarkers"},{"issue":"12","key":"10.1016\/bs.acc.2025.10.012_bib131","doi-asserted-by":"crossref","first-page":"5860","DOI":"10.1002\/alz.13390","article-title":"Artificial intelligence for biomarker discovery in Alzheimer\u2019s disease and dementia","volume":"19","author":"Winchester","year":"2023","journal-title":"Alzheimer\u2019s & Dement"},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib132","first-page":"27","article-title":"Genomics and artificial intelligence: prostate cancer","volume":"51","author":"Wong","year":"2024","journal-title":"Urologic Clin"},{"issue":"12","key":"10.1016\/bs.acc.2025.10.012_bib133","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-053674","article-title":"Biomarker discovery studies for patient stratification using machine learning analysis of omics data: a scoping review","volume":"11","author":"Glaab","year":"2021","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib134","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s00441-023-03816-z","article-title":"The benefits and pitfalls of machine learning for biomarker discovery","volume":"394","author":"Ng","year":"2023","journal-title":"Cell Tissue Res."},{"key":"10.1016\/bs.acc.2025.10.012_bib135","doi-asserted-by":"crossref","DOI":"10.1016\/j.resourpol.2023.104250","article-title":"Artificial intelligence, machine learning and big data in natural resources management: a comprehensive bibliometric review of literature spanning 1975\u20132022","volume":"86","author":"Pandey","year":"2023","journal-title":"Resour. Policy"},{"key":"10.1016\/bs.acc.2025.10.012_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101730","article-title":"Multi-omics research strategies in ischemic stroke: a multidimensional perspective","volume":"81","author":"Li","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/bs.acc.2025.10.012_bib137","doi-asserted-by":"crossref","first-page":"3735","DOI":"10.1016\/j.csbj.2021.06.030","article-title":"Integration strategies of multi-omics data for machine learning analysis","volume":"19","author":"Picard","year":"2021","journal-title":"Comput.\u00a0Struct. Biotechnol. J."},{"issue":"8","key":"10.1016\/bs.acc.2025.10.012_bib138","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.jpha.2023.06.011","article-title":"Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective","volume":"13","author":"O'Connor","year":"2023","journal-title":"J. Pharm. Anal."},{"issue":"3","key":"10.1016\/bs.acc.2025.10.012_bib139","doi-asserted-by":"crossref","first-page":"bbae185","DOI":"10.1093\/bib\/bbae185","article-title":"DeepKEGG: a multi-omics data integration framework with biological insights for cancer recurrence prediction and biomarker discovery","volume":"25","author":"Lan","year":"2024","journal-title":"Brief. Bioinforma"},{"issue":"11","key":"10.1016\/bs.acc.2025.10.012_bib140","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.3390\/ijms25115880","article-title":"Bioinformatics analysis and validation of potential markers associated with prediction and prognosis of gastric cancer","volume":"25","author":"Matsuoka","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/bs.acc.2025.10.012_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.126710","article-title":"Multi-omics analysis identified extracellular vesicles as biomarkers for cardiovascular diseases","author":"Meng","year":"2024","journal-title":"Talanta"},{"issue":"6","key":"10.1016\/bs.acc.2025.10.012_bib142","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.bbabio.2011.03.006","article-title":"Metabolomics for mitochondrial and cancer studies","volume":"1807","author":"Nagrath","year":"2011","journal-title":"Biochimica et. Biophysica Acta (BBA)-Bioenergetics"},{"key":"10.1016\/bs.acc.2025.10.012_bib143","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2023.117423","article-title":"Electrochemical nanobiosensors for the detection of cancer biomarkers in real samples: Trends and challenges","volume":"170","author":"Achi","year":"2024","journal-title":"TrAC. Trends Anal. Chem."},{"issue":"36","key":"10.1016\/bs.acc.2025.10.012_bib144","doi-asserted-by":"crossref","first-page":"2400595","DOI":"10.1002\/advs.202400595","article-title":"Revolutionary point\u2010of\u2010care wearable diagnostics for early disease detection and biomarker discovery through intelligent technologies","volume":"11","author":"Haghayegh","year":"2024","journal-title":"Adv. Sci."},{"key":"10.1016\/bs.acc.2025.10.012_bib145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcvp.2024.100194","article-title":"Next generation sequencing-based transcriptome data mining for virus identification and characterization: review on recent progress and prospect","author":"Rahimian","year":"2024","journal-title":"J. Clin. Virology Plus"},{"issue":"3","key":"10.1016\/bs.acc.2025.10.012_bib146","doi-asserted-by":"crossref","first-page":"227","DOI":"10.2174\/2213235X113019990005","article-title":"Biomarker discovery and translation in metabolomics","volume":"1","author":"Nagana Gowda","year":"2013","journal-title":"Curr. Metabolomics"},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib147","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1373\/clinchem.2011.169573","article-title":"Metabolomics and cardiovascular biomarker discovery","volume":"58","author":"Rhee","year":"2012","journal-title":"Clin. Chem."},{"issue":"8","key":"10.1016\/bs.acc.2025.10.012_bib148","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1074\/mcp.M111.016006","article-title":"Urine metabolomics analysis for biomarker discovery and detection of jaundice syndrome in patients with liver disease","volume":"11","author":"Wang","year":"2012","journal-title":"Mol. & Cell. Proteom."},{"issue":"10","key":"10.1016\/bs.acc.2025.10.012_bib149","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3390\/metabo11100672","article-title":"New advances in tissue metabolomics: a review","volume":"11","author":"Saoi","year":"2021","journal-title":"Metabolites"},{"key":"10.1016\/bs.acc.2025.10.012_bib150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2019.112057","article-title":"Application of metabolomics for unveiling the therapeutic role of traditional Chinese medicine in metabolic diseases","volume":"242","author":"Wu","year":"2019","journal-title":"J. Ethnopharmacol."},{"issue":"19-20","key":"10.1016\/bs.acc.2025.10.012_bib151","doi-asserted-by":"crossref","first-page":"6487","DOI":"10.1007\/s00018-021-03918-3","article-title":"Metabolomics and health: from nutritional crops and plant-based pharmaceuticals to profiling of human biofluids","volume":"78","author":"Marchev","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/bs.acc.2025.10.012_bib152","doi-asserted-by":"crossref","DOI":"10.1016\/j.ibmed.2023.100101","article-title":"Machine learning for metabolomics research in drug discovery","author":"Martinelli","year":"2023","journal-title":"Intelligence-Based Med."},{"issue":"1","key":"10.1016\/bs.acc.2025.10.012_bib153","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3390\/ijms25010182","article-title":"Personalized medicine in severe asthma: from biomarkers to biologics","volume":"25","author":"Chen","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"3-4","key":"10.1016\/bs.acc.2025.10.012_bib154","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000437435","article-title":"Personalized medicine: review and perspectives of promising baseline EEG biomarkers in major depressive disorder and attention deficit hyperactivity disorder","volume":"72","author":"Olbrich","year":"2016","journal-title":"Neuropsychobiology"},{"issue":"4","key":"10.1016\/bs.acc.2025.10.012_bib155","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.3390\/cimb46040186","article-title":"Precision dermatology: a review of molecular biomarkers and personalized therapies","volume":"46","author":"Tan","year":"2024","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/bs.acc.2025.10.012_bib156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1479-5876-12-144","article-title":"Cohort profile: Greifswald approach to individualized medicine (GANI_MED)","volume":"12","author":"Grabe","year":"2014","journal-title":"J. Transl. Med."},{"key":"10.1016\/bs.acc.2025.10.012_bib157","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2023.110932","article-title":"Unveiling the potential of proteomic and genetic signatures for precision therapeutics in lung cancer management","volume":"113","author":"Srivastava","year":"2024","journal-title":"Cell. Signal"},{"issue":"7","key":"10.1016\/bs.acc.2025.10.012_bib158","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.cell.2024.02.041","article-title":"Cancer biomarkers: emerging trends and clinical implications for personalized treatment","volume":"187","author":"Passaro","year":"2024","journal-title":"Cell"},{"issue":"1-2","key":"10.1016\/bs.acc.2025.10.012_bib159","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10540-005-2851-3","article-title":"Clinical proteomics: from biomarker discovery and cell signaling profiles to individualized personal therapy","volume":"25","author":"Calvo","year":"2005","journal-title":"Biosci. Rep."},{"key":"10.1016\/bs.acc.2025.10.012_bib160","doi-asserted-by":"crossref","DOI":"10.1016\/j.cytogfr.2024.08.006","article-title":"Biomarker discovery in hepatocellular carcinoma (HCC) for personalized treatment and enhanced prognosis","author":"Yu","year":"2024","journal-title":"Cytokine & Growth Factor. Rev."},{"key":"10.1016\/bs.acc.2025.10.012_bib161","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2024.155567","article-title":"Emerging methods and techniques for cancer biomarker discovery","author":"Dakal","year":"2024","journal-title":"Pathology-Research Pract."}],"container-title":["Advances in Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065242325001088?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065242325001088?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T01:43:05Z","timestamp":1768959785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065242325001088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443470943"],"references-count":161,"URL":"https:\/\/doi.org\/10.1016\/bs.acc.2025.10.012","relation":{},"ISSN":["0065-2423"],"issn-type":[{"value":"0065-2423","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}