{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:12:56Z","timestamp":1790644376577,"version":"4.1.0"},"reference-count":185,"publisher":"Elsevier","isbn-type":[{"value":"9780443470981","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.acc.2026.01.006","type":"book-chapter","created":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T20:23:35Z","timestamp":1771878215000},"page":"1-44","source":"Crossref","is-referenced-by-count":1,"title":["Drug induced renal injury (DIRI) biomarkers"],"prefix":"10.1016","author":[{"given":"Emina Karahmet","family":"Sher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijana Markovi\u0107","family":"Boras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almir","family":"Fajki\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faris","family":"Begovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.acc.2026.01.006_bib1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/phar.2152","article-title":"Drug\u2010associated acute kidney injury identified in the United States food and drug administration adverse event reporting system database","volume":"38","author":"Welch","year":"2018","journal-title":"Pharmacotherapy: J Hum Pharmacology Drug Ther"},{"key":"10.1016\/bs.acc.2026.01.006_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22116109","article-title":"The mechanism of drug nephrotoxicity and the methods for preventing kidney damage","volume":"22","author":"Kwiatkowska","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/bs.acc.2026.01.006_bib3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3390\/jcm10020168","article-title":"Drug-induced acute kidney injury: A study from the french medical administrative and the french national pharmacovigilance databases using capture-recapture method","volume":"10","author":"Rolland","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/bs.acc.2026.01.006_bib4","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.2215\/CJN.11290821","article-title":"Drug-induced acute kidney injury","volume":"17","author":"Perazella","year":"2022","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/bs.acc.2026.01.006_bib5","article-title":"Drug-induced kidney injury: challenges and opportunities","volume":"13","author":"Connor","year":"2024","journal-title":"Toxicol Res (Camb)"},{"key":"10.1016\/bs.acc.2026.01.006_bib6","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1111\/bcp.13216","article-title":"The drugs that mostly frequently induce acute kidney injury: a case\u00a0\u2212\u00a0noncase study of a pharmacovigilance database","volume":"83","author":"Pierson\u2010Marchandise","year":"2017","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/bs.acc.2026.01.006_bib7","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/fcp.12758","article-title":"Risk factors for and characteristics of community\u2010 and hospital\u2010acquired drug\u2010induced acute kidney injuries","volume":"36","author":"Rey","year":"2022","journal-title":"Fundam Clin Pharmacol"},{"key":"10.1016\/bs.acc.2026.01.006_bib8","doi-asserted-by":"crossref","first-page":"656","DOI":"10.2174\/1389200220666190711114504","article-title":"Serial quantification of urinary protein biomarkers to predict drug-induced acute kidney injury","volume":"20","author":"Da","year":"2019","journal-title":"Curr Drug Metab"},{"key":"10.1016\/bs.acc.2026.01.006_bib9","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s40264-017-0565-7","article-title":"Clinical relevance and predictive value of damage biomarkers of drug-induced kidney injury","volume":"40","author":"Kane-Gill","year":"2017","journal-title":"Drug Saf"},{"key":"10.1016\/bs.acc.2026.01.006_bib10","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s40264-022-01202-2","article-title":"Kidney damage and stress biomarkers for early identification of drug-induced kidney injury: a systematic review","volume":"45","author":"Desai","year":"2022","journal-title":"Drug Saf"},{"key":"10.1016\/bs.acc.2026.01.006_bib11","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1053\/j.ajkd.2021.09.018","article-title":"Associations of plasma biomarkers of inflammation, fibrosis, and kidney tubular injury with progression of diabetic kidney disease: a cohort study","volume":"79","author":"Guti\u00e9rrez","year":"2022","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/bs.acc.2026.01.006_bib12","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1681\/ASN.2013070758","article-title":"Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes","volume":"25","author":"Sabbisetti","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/bs.acc.2026.01.006_bib13","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.3390\/ijms23042052","article-title":"Vancomycin-associated acute kidney injury: a narrative review from pathophysiology to clinical application","volume":"23","author":"Kan","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/bs.acc.2026.01.006_bib14","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.ekir.2023.08.031","article-title":"Overview of antibiotic-induced nephrotoxicity","volume":"8","author":"Campbell","year":"2023","journal-title":"Kidney Int Rep"},{"key":"10.1016\/bs.acc.2026.01.006_bib15","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1080\/17425255.2018.1511701","article-title":"Biomarkers of drug-induced acute kidney injury: a regulatory perspective","volume":"14","author":"Blank","year":"2018","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"10.1016\/bs.acc.2026.01.006_bib16","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1007\/s43441-023-00599-x","article-title":"Detection, monitoring, and mitigation of drug-induced nephrotoxicity: a pragmatic approach","volume":"58","author":"Antognini","year":"2024","journal-title":"Ther Innov Regul Sci"},{"key":"10.1016\/bs.acc.2026.01.006_bib17","doi-asserted-by":"crossref","DOI":"10.1097\/CCM.0b013e3181de0c60","article-title":"Drug-induced acute kidney injury in the critically ill adult: recognition and prevention strategies","volume":"38","author":"Bentley","year":"2010","journal-title":"Crit Care Med"},{"key":"10.1016\/bs.acc.2026.01.006_bib18","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ki.2015.115","article-title":"Phenotype standardization for drug-induced kidney disease","volume":"88","author":"Mehta","year":"2015","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/bs.acc.2026.01.006_bib19","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1053\/j.ajkd.2017.11.021","article-title":"Management of acute kidney injury: core curriculum 2018","volume":"72","author":"Moore","year":"2018","journal-title":"AJKD"},{"key":"10.1016\/bs.acc.2026.01.006_bib20","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.kint.2020.04.020","article-title":"Controversies in acute kidney injury: conclusions from a kidney disease: improving global outcomes (KDIGO) conference","volume":"98","author":"Ostermann","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/bs.acc.2026.01.006_bib21","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/CIR.0000000000001040","article-title":"Comprehensive management of cardiovascular risk factors for adults with type 2 diabetes: a scientific statement from the American Heart Association","volume":"145","author":"Joseph","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/bs.acc.2026.01.006_bib22","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s40264-017-0602-6","article-title":"Can SGLT2 inhibitors cause acute renal failure? Plausible role for altered glomerular hemodynamics and medullary hypoxia","volume":"41","author":"Szalat","year":"2018","journal-title":"Drug Saf"},{"key":"10.1016\/bs.acc.2026.01.006_bib23","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.2215\/CJN.02050309","article-title":"Renal vulnerability to drug toxicity","volume":"4","author":"Perazella","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/bs.acc.2026.01.006_bib24","unstructured":"R. Luciano, M.A. Perazella, NSAIDs: acute kidney injury (acute renal failure), uptodate Waltham, MA. Https:\/\/Www. Uptodate. Com\/Contents\/Nsaids-Acute-Kidney-Injury-Acute-Renal-Failure. Last Update March, 2017."},{"key":"10.1016\/bs.acc.2026.01.006_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.705636","article-title":"The role of urinary biomarkers as diagnostic and prognostic predictors of acute kidney injury associated with vancomycin","volume":"12","author":"Sampaio de Souza Garms","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/bs.acc.2026.01.006_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.01079","article-title":"The role of mitochondria in drug-induced kidney injury","volume":"11","author":"Gai","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/bs.acc.2026.01.006_bib27","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.1073\/pnas.89.14.6418","article-title":"ATP is a coupling modulator of parallel Na,K-ATPase-K-channel activity in the renal proximal tubule","volume":"89","author":"Tsuchiya","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/bs.acc.2026.01.006_bib28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.apsb.2016.07.013","article-title":"Renal drug transporters and their significance in drug\u2013drug interactions","volume":"6","author":"Yin","year":"2016","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/bs.acc.2026.01.006_bib29","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000525561","article-title":"Facing the challenge of drug-induced acute interstitial nephritis","volume":"147","author":"Sanchez-Alamo","year":"2023","journal-title":"Nephron"},{"key":"10.1016\/bs.acc.2026.01.006_bib30","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41581-024-00875-5","article-title":"Lymphocytes and innate immune cells in acute kidney injury and repair","volume":"20","author":"Lee","year":"2024","journal-title":"Nat Rev Nephrol"},{"issue":"12","key":"10.1016\/bs.acc.2026.01.006_bib31","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1038\/s41401-021-00620-9","article-title":"Natural products: potential treatments for cisplatin-induced nephrotoxicity","volume":"42","author":"Yan Fang","year":"2021","journal-title":"Acta Pharmacologica Sin"},{"key":"10.1016\/bs.acc.2026.01.006_bib32","first-page":"550","article-title":"Drug-induced acute kidney injury: diverse mechanisms of tubular injury","volume":"25","author":"Perazella","year":"2019","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/bs.acc.2026.01.006_bib33","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/jac\/dkaa184","article-title":"Relationship of vancomycin trough levels with acute kidney injury risk: an exposure-toxicity meta-analysis","volume":"75","author":"Bellos","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/bs.acc.2026.01.006_bib34","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/ajhp\/zxaa036","article-title":"Therapeutic monitoring of vancomycin for serious methicillin-resistant Staphylococcus aureus infections: a revised consensus guideline and review by the American Society of health-system pharmacists, the infectious diseases society of America, the Pediat","volume":"77","author":"Rybak","year":"2020","journal-title":"Am J Health Syst Pharm"},{"key":"10.1016\/bs.acc.2026.01.006_bib35","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1111\/bcp.15429","article-title":"Risk factors for vancomycin-associated acute kidney injury: a systematic review and meta-analysis","volume":"88","author":"Kim","year":"2022","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/bs.acc.2026.01.006_bib36","doi-asserted-by":"crossref","first-page":"372","DOI":"10.34067\/KID.0007282021","article-title":"Vancomycin-associated cast nephropathy: reality or fantasy?","volume":"3","author":"Stokes","year":"2022","journal-title":"Kidney360"},{"key":"10.1016\/bs.acc.2026.01.006_bib37","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s12325-023-02436-x","article-title":"Aminoglycoside-related nephrotoxicity and ototoxicity in clinical practice: a review of pathophysiological mechanism and treatment options","volume":"40","author":"Le","year":"2023","journal-title":"Adv Ther"},{"key":"10.1016\/bs.acc.2026.01.006_bib38","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.2174\/1871520621666211126090906","article-title":"Role of mitochondrial membrane potential and lactate dehydrogenase a in apoptosis","volume":"22","author":"Zaib","year":"2022","journal-title":"Anticancer Agents Med Chem"},{"key":"10.1016\/bs.acc.2026.01.006_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2023.107035","article-title":"Battle of polymyxin induced nephrotoxicity: polymyxin B versus colistin","volume":"63","author":"Ball\u0131","year":"2024","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/bs.acc.2026.01.006_bib40","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/phar.2209","article-title":"International consensus guidelines for the optimal use of the polymyxins: endorsed by the American College of Clinical Pharmacy (ACCP), European society of clinical microbiology and infectious diseases (ESCMID), Infectious Diseases Society of America (ID)","volume":"39","author":"Tsuji","year":"2019","journal-title":"Pharmacotherapy"},{"key":"10.1016\/bs.acc.2026.01.006_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.115928","article-title":"Delineation of the molecular mechanisms underlying colistin-mediated toxicity using metabolomic and transcriptomic analyses","volume":"439","author":"Long","year":"2022","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/bs.acc.2026.01.006_bib42","doi-asserted-by":"crossref","first-page":"333","DOI":"10.18433\/jpps30865","article-title":"Pharmacokinetics and toxicokinetics roles of membrane transporters at kidney level","volume":"23","author":"Veiga-Matos","year":"2020","journal-title":"J Pharm Pharm Sci"},{"key":"10.1016\/bs.acc.2026.01.006_bib43","article-title":"Tenofovir disoproxil fumarate is a new substrate of ATP-binding cassette subfamily C member 11","volume":"61","author":"Tun-Yhong","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/bs.acc.2026.01.006_bib44","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1056\/NEJMra1508467","article-title":"Kidney diseases associated with human immunodeficiency virus infection","volume":"377","author":"Cohen","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/bs.acc.2026.01.006_bib45","first-page":"325","article-title":"A synopsis of current theories on drug-induced nephrotoxicity","volume":"13","author":"Dobrek","year":"2023","journal-title":"Life 2023"},{"key":"10.1016\/bs.acc.2026.01.006_bib46","unstructured":"CDC surveillance system: trends in prescribed NSAID Usage, (n.d.). https:\/\/nccd.cdc.gov\/ckd\/detail.aspx?Qnum=Q700."},{"key":"10.1016\/bs.acc.2026.01.006_bib47","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1055\/s-0030-1267855","article-title":"Pharmacology of nonsteroidal antiinflammatory drugs and opioids","volume":"27","author":"Slater","year":"2010","journal-title":"Semin Intervent Radiol"},{"key":"10.1016\/bs.acc.2026.01.006_bib48","article-title":"Non steroidal antiinflammatory drugs may be harmful to normal kidneys: experimental surgery model\u204e","volume":"16","author":"Hur","year":"2012","journal-title":"Hippokratia"},{"key":"10.1016\/bs.acc.2026.01.006_bib49","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.canlet.2014.01.021","article-title":"Anti-tumor activity of non-steroidal anti-inflammatory drugs: cyclooxygenase-independent targets","volume":"346","author":"Liggett","year":"2014","journal-title":"Cancer Lett"},{"key":"10.1016\/bs.acc.2026.01.006_bib50","doi-asserted-by":"crossref","first-page":"37302","DOI":"10.1074\/jbc.M110.148882","article-title":"Suppression of expression of endoplasmic reticulum chaperones by Helicobacter pylori and its role in exacerbation of non-steroidal anti-inflammatory drug-induced gastric lesions","volume":"285","author":"Namba","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/bs.acc.2026.01.006_bib51","article-title":"Side effects of radiographic contrast media: pathogenesis, risk factors, and prevention","volume":"2014","author":"Andreucci","year":"2014","journal-title":"Biomed Res Int"},{"key":"10.1016\/bs.acc.2026.01.006_bib52","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.ejrad.2019.03.008","article-title":"Nephrotoxicity of iodinated contrast media: from pathophysiology to prevention strategies","volume":"116","author":"Faucon","year":"2019","journal-title":"Eur J Radiol"},{"key":"10.1016\/bs.acc.2026.01.006_bib53","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.bcp.2006.08.008","article-title":"Radiocontrast media cause dephosphorylation of Akt and downstream signaling targets in human renal proximal tubular cells","volume":"72","author":"Andreucci","year":"2006","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/bs.acc.2026.01.006_bib54","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3390\/jcm10020271","article-title":"Gadolinium-based contrast media nephrotoxicity in kidney impairment: the physio-pathological conditions for the perfect murder","volume":"10","author":"Martino","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/bs.acc.2026.01.006_bib55","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/cpt.2630","article-title":"Blockade of organic anion transport in humans after treatment with the drug probenecid leads to major metabolic alterations in plasma and urine","volume":"112","author":"Granados","year":"2022","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/bs.acc.2026.01.006_bib56","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1053\/j.ackd.2019.08.001","article-title":"Nephrotoxicity of antimicrobials and antibiotics","volume":"27","author":"Morales-Alvarez","year":"2020","journal-title":"Adv Chronic Kidney Dis"},{"key":"10.1016\/bs.acc.2026.01.006_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.drudis.2024.103938","article-title":"Generation of a drug-induced renal injury list to facilitate the development of new approach methodologies for nephrotoxicity","volume":"29","author":"Connor","year":"2024","journal-title":"Drug Discov Today"},{"key":"10.1016\/bs.acc.2026.01.006_bib58","doi-asserted-by":"crossref","first-page":"S117","DOI":"10.1016\/j.kint.2023.10.018","article-title":"KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease","volume":"105","author":"Stevens","year":"2024","journal-title":"Kidney Int"},{"key":"10.1016\/bs.acc.2026.01.006_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jac\/dkz325","article-title":"Mechanisms of antimicrobial-induced nephrotoxicity in children","volume":"75","author":"Downes","year":"2020","journal-title":"J Antimicrobial Chemotherapy"},{"key":"10.1016\/bs.acc.2026.01.006_bib60","doi-asserted-by":"crossref","first-page":"115","DOI":"10.15420\/ecr.2014.9.2.115","article-title":"Hypertension in chronic kidney disease \u2013 role of arterial calcification and impact on treatment","volume":"9","author":"Phan","year":"2014","journal-title":"Eur Cardiol\u00a0Rev"},{"key":"10.1016\/bs.acc.2026.01.006_bib61","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s12325-021-01939-9","article-title":"Drug interactions affecting kidney function: beware of health threats from triple whammy","volume":"39","author":"Har\u0119\u017clak","year":"2022","journal-title":"Adv Ther"},{"key":"10.1016\/bs.acc.2026.01.006_bib62","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1124\/dmd.122.000967","article-title":"Emerging roles of uremic toxins and inflammatory cytokines in the alteration of hepatic drug disposition in patients with kidney dysfunction","volume":"51","author":"Arakawa","year":"2023","journal-title":"Drug Metab Disposition"},{"key":"10.1016\/bs.acc.2026.01.006_bib63","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/his.13064","article-title":"Drug-induced nephropathies","volume":"70","author":"Paueksakon","year":"2017","journal-title":"Histopathology"},{"key":"10.1016\/bs.acc.2026.01.006_bib64","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.arr.2016.12.002","article-title":"Biomarkers associated with sedentary behaviour in older adults: a systematic review","volume":"35","author":"Wirth","year":"2017","journal-title":"Ageing Res Rev"},{"key":"10.1016\/bs.acc.2026.01.006_bib65","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.cca.2019.08.030","article-title":"Chronic kidney disease: biomarker diagnosis to therapeutic targets","volume":"499","author":"Wang","year":"2019","journal-title":"Clinica Chim Acta"},{"key":"10.1016\/bs.acc.2026.01.006_bib66","first-page":"57","article-title":"Urine biomarkers in the early stages of diseases: current status and perspective","volume":"25","author":"Jing","year":"2018","journal-title":"Discov Med"},{"key":"10.1016\/bs.acc.2026.01.006_bib67","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1440-1797.2010.01361.x","article-title":"Review: serum and urine biomarkers of kidney disease: a pathophysiological perspective","volume":"15","author":"Tesch","year":"2010","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/bs.acc.2026.01.006_bib68","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.burns.2017.01.023","article-title":"Acute kidney injury after burn","volume":"43","author":"Clark","year":"2017","journal-title":"Burns"},{"key":"10.1016\/bs.acc.2026.01.006_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113600","article-title":"Blood urea nitrogen to albumin ratio predicts risk of acute kidney injury and in-hospital mortality associated with immunological and surgical diseases: a retrospective analysis of 1994 patients","volume":"143","author":"Chen","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/bs.acc.2026.01.006_bib70","doi-asserted-by":"crossref","DOI":"10.1080\/0886022X.2025.2540563","article-title":"A new category for understanding the mechanisms of drug-induced kidney injury","volume":"47","author":"Liu","year":"2025","journal-title":"Ren Fail"},{"key":"10.1016\/bs.acc.2026.01.006_bib71","doi-asserted-by":"crossref","first-page":"2962","DOI":"10.1001\/jama.1984.03350210018019","article-title":"False elevation in serum creatinine levels","volume":"252","author":"Herrington","year":"1984","journal-title":"JAMA"},{"key":"10.1016\/bs.acc.2026.01.006_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13054-023-04720-2","article-title":"Moving toward a contemporary classification of drug-induced kidney disease","volume":"27","author":"Karimzadeh","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/bs.acc.2026.01.006_bib73","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s00011-017-1043-5","article-title":"Resistin and NGAL are associated with inflammatory response, endothelial activation and clinical outcomes in sepsis","volume":"66","author":"Macdonald","year":"2017","journal-title":"Inflamm Res"},{"key":"10.1016\/bs.acc.2026.01.006_bib74","doi-asserted-by":"crossref","first-page":"10470","DOI":"10.3390\/ijms241310470","article-title":"The review of current knowledge on neutrophil gelatinase-associated lipocalin (NGAL)","volume":"24","author":"Romejko","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/bs.acc.2026.01.006_bib75","doi-asserted-by":"crossref","first-page":"155","DOI":"10.5604\/01.3001.0012.7907","article-title":"Serum NGAL is superior to cystatin C in predicting the prognosis of acute-on-chronic liver failure","volume":"18","author":"Lu","year":"2019","journal-title":"Ann Hepatol"},{"key":"10.1016\/bs.acc.2026.01.006_bib76","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1053\/j.ackd.2008.04.003","article-title":"Biomarkers of acute kidney injury","volume":"15","author":"Edelstein","year":"2008","journal-title":"Adv Chronic Kidney Dis"},{"key":"10.1016\/bs.acc.2026.01.006_bib77","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3892\/ol.2020.12409","article-title":"Role of neutrophil gelatinase-associated lipocalin in renal cell carcinoma (review)","volume":"21","author":"Che","year":"2020","journal-title":"Oncol Lett"},{"key":"10.1016\/bs.acc.2026.01.006_bib78","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/toxsci\/kfaa029","article-title":"Impaired tubular reabsorption is the main mechanism explaining increases in urinary NGAL excretion following acute kidney injury in rats","volume":"175","author":"Sancho-Mart\u00ednez","year":"2020","journal-title":"Toxicological Sci"},{"key":"10.1016\/bs.acc.2026.01.006_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2019.113664","article-title":"Clinical prospects of biomarkers for the early detection and\/or prediction of organ injury associated with pharmacotherapy","volume":"170","author":"Tajima","year":"2019","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/bs.acc.2026.01.006_bib80","doi-asserted-by":"crossref","first-page":"307","DOI":"10.33549\/physiolres.934212","article-title":"NGAL, albumin and cystatin C during cisplatin therapy","author":"Florova","year":"2020","journal-title":"Physiol Res"},{"key":"10.1016\/bs.acc.2026.01.006_bib81","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3390\/ijms25021074","article-title":"The value of urinary NGAL, KIM-1, and IL-18 measurements in the early detection of kidney injury in oncologic patients treated with cisplatin-based chemotherapy","volume":"25","author":"Szumilas","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/bs.acc.2026.01.006_bib82","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.cca.2022.08.029","article-title":"Neutrophil gelatinase-associated lipocalin (NGAL) in kidney injury \u2013 a systematic review","volume":"536","author":"Marakala","year":"2022","journal-title":"Clinica Chim Acta"},{"key":"10.1016\/bs.acc.2026.01.006_bib83","doi-asserted-by":"crossref","first-page":"8312","DOI":"10.1038\/s41598-022-12286-2","article-title":"Urinary neutrophil gelatinase-associated lipocalin (NGAL) can potentially predict vascular complications and reliably risk stratify patients with peripheral arterial disease","volume":"12","author":"Ehsan","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/bs.acc.2026.01.006_bib84","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.21873\/invivo.12560","article-title":"Neutrophil gelatinase-associated lipocalin predicts post-traumatic acute kidney injury in severely injured patients","volume":"35","author":"Leditzke","year":"2021","journal-title":"Vivo (Brooklyn)"},{"key":"10.1016\/bs.acc.2026.01.006_bib85","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jim.2019.04.004","article-title":"Development of a novel immunoassay for the simple and fast quantitation of neutrophil gelatinase-associated lipocalin using europium(III) chelate microparticles and magnetic beads","volume":"470","author":"Wang","year":"2019","journal-title":"J Immunol Methods"},{"key":"10.1016\/bs.acc.2026.01.006_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2024.125960","article-title":"Disposable label-free electrochemical immunosensor based on gold nanoparticles-Prussian blue for neutrophil gelatinase-associated lipocalin detection in urine samples","volume":"274","author":"Phonklam","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/bs.acc.2026.01.006_bib87","doi-asserted-by":"crossref","DOI":"10.1002\/rcm.8637","article-title":"Absolute quantification of urinary neutrophil gelatinase\u2010associated lipocalin by ultra\u2010high\u2010performance liquid chromatography\/tandem mass spectrometry and the diagnostic efficacy of acute kidney injury","volume":"34","author":"Ji","year":"2020","journal-title":"Rapid Commun Mass Spectrometry"},{"key":"10.1016\/bs.acc.2026.01.006_bib88","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.talanta.2018.11.050","article-title":"Ultra-high-performance liquid chromatography-mass spectrometry method for neutrophil gelatinase-associated lipocalin as a predictive biomarker in acute kidney injury","volume":"195","author":"Ion","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/bs.acc.2026.01.006_bib89","first-page":"1219","article-title":"Understanding kidney injury molecule 1: a novel immune factor in kidney pathophysiology","volume":"11","author":"Song","year":"2019","journal-title":"Am J Transl Res"},{"key":"10.1016\/bs.acc.2026.01.006_bib90","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.ymthe.2022.08.013","article-title":"KIM-1 augments hypoxia-induced tubulointerstitial inflammation through uptake of small extracellular vesicles by tubular epithelial cells","volume":"31","author":"Chen","year":"2023","journal-title":"Mol Ther"},{"key":"10.1016\/bs.acc.2026.01.006_bib91","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s40264-024-01474-w","article-title":"An integrated approach for representing knowledge on the potential of drugs to cause acute kidney injury","volume":"48","author":"Fern\u00e1ndez-Llaneza","year":"2025","journal-title":"Drug Saf"},{"key":"10.1016\/bs.acc.2026.01.006_bib92","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/cpt.606","article-title":"Profiling of kidney injury biomarkers in patients receiving cisplatin: time\u2010dependent changes in the absence of clinical nephrotoxicity","volume":"101","author":"George","year":"2017","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/bs.acc.2026.01.006_bib93","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167731","article-title":"Longitudinal biomarkers and kidney disease progression after acute kidney injury","volume":"8","author":"Wen","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/bs.acc.2026.01.006_bib94","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cca.2018.09.011","article-title":"Urinary kidney injury molecule-1 in renal disease","volume":"487","author":"Moresco","year":"2018","journal-title":"Clinica Chim Acta"},{"key":"10.1016\/bs.acc.2026.01.006_bib95","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s13054-016-1455-6","article-title":"High urinary excretion of kidney injury molecule-1 predicts adverse outcomes in acute kidney injury: a case control study","volume":"20","author":"Xie","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/bs.acc.2026.01.006_bib96","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1681\/ASN.0000000000000334","article-title":"Sensing dying cells in health and disease","volume":"35","author":"Tutunea-Fatan","year":"2024","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/bs.acc.2026.01.006_bib97","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/cpt.606","article-title":"Profiling of kidney injury biomarkers in patients receiving cisplatin: time\u2010dependent changes in the absence of clinical nephrotoxicity","volume":"101","author":"George","year":"2017","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/bs.acc.2026.01.006_bib98","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/s41581-023-00694-0","article-title":"Regulated cell death pathways in kidney disease","volume":"19","author":"Sanz","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/bs.acc.2026.01.006_bib99","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s13054-022-04223-6","article-title":"Comparative accuracy of biomarkers for the prediction of hospital-acquired acute kidney injury: a systematic review and meta-analysis","volume":"26","author":"Pan","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/bs.acc.2026.01.006_bib100","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12967-021-02776-8","article-title":"The value of kidney injury molecule 1 in predicting acute kidney injury in adult patients: a systematic review and Bayesian meta-analysis","volume":"19","author":"Geng","year":"2021","journal-title":"J Transl Med"},{"key":"10.1016\/bs.acc.2026.01.006_bib101","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/s12882-023-03262-7","article-title":"Urinary N-acetyl-beta-D-glucosaminidase levels predict immunoglobulin a nephropathy remission status","volume":"24","author":"Liu","year":"2023","journal-title":"BMC Nephrol"},{"key":"10.1016\/bs.acc.2026.01.006_bib102","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.toxlet.2018.10.027","article-title":"Urinary biomarker evaluation for early detection of gentamycin-induced acute kidney injury","volume":"300","author":"Sun","year":"2019","journal-title":"Toxicol Lett"},{"issue":"1","key":"10.1016\/bs.acc.2026.01.006_bib103","first-page":"S14","article-title":"The role of NAG (N-acetyl-beta-D-glucosaminidase) in the diagnosis of kidney disease including the monitoring of nephrotoxicity","volume":"38","author":"Price","year":"1992","journal-title":"Clin Nephrol"},{"key":"10.1016\/bs.acc.2026.01.006_bib104","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1186\/s12887-022-03416-w","article-title":"The role of urinary N-acetyl-\u03b2-D-glucosaminidase in early detection of acute kidney injury among pediatric patients with neoplastic disorders in a retrospective study","volume":"22","author":"B\u00edr\u00f3","year":"2022","journal-title":"BMC Pediatr"},{"key":"10.1016\/bs.acc.2026.01.006_bib105","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0009-8981(79)90415-7","article-title":"levels and diabetic microangiopathy","volume":"97","author":"Whiting","year":"1979","journal-title":"Clinica Chim Acta"},{"key":"10.1016\/bs.acc.2026.01.006_bib106","doi-asserted-by":"crossref","first-page":"275","DOI":"10.18388\/abp.2014_1896","article-title":"N-acetyl-beta-glucosaminidase urine activity as a marker of early proximal tubule damage and a predictor of the long-term function of the transplanted kidneys","volume":"61","author":"Kwiatkowska","year":"2014","journal-title":"Acta Biochim Pol"},{"key":"10.1016\/bs.acc.2026.01.006_bib107","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.1021\/acs.analchem.0c00989","article-title":"Multiplex optical urinalysis for early detection of drug-induced kidney injury","volume":"92","author":"Cheng","year":"2020","journal-title":"Anal Chem"},{"key":"10.1016\/bs.acc.2026.01.006_bib108","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jss.2007.03.037","article-title":"The role of interleukin-18 in renal injury","volume":"145","author":"Leslie","year":"2008","journal-title":"J Surgical Res"},{"key":"10.1016\/bs.acc.2026.01.006_bib109","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s40620-014-0113-9","article-title":"Urine interleukin-18 in prediction of acute kidney injury: a systemic review and meta-analysis","volume":"28","author":"Lin","year":"2015","journal-title":"J Nephrol"},{"key":"10.1016\/bs.acc.2026.01.006_bib110","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1155\/2013\/369784","article-title":"Interleukin 18 as a marker of chronic nephropathy in children after anticancer treatment","volume":"35","author":"Zubowska","year":"2013","journal-title":"Dis Markers"},{"key":"10.1016\/bs.acc.2026.01.006_bib111","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26538","article-title":"Urine biomarkers of acute kidney injury in noncritically ill, hospitalized children treated with chemotherapy","volume":"64","author":"Sterling","year":"2017","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/bs.acc.2026.01.006_bib112","article-title":"Interleukin-18 in inflammatory kidney disease","volume":"8","author":"Hirooka","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/bs.acc.2026.01.006_bib113","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/bja\/aeu382","article-title":"Predictive value of urine interleukin-18 in the evolution and outcome of acute kidney injury in critically ill adult patients","volume":"114","author":"Nisula","year":"2015","journal-title":"Br J Anaesth"},{"key":"10.1016\/bs.acc.2026.01.006_bib114","doi-asserted-by":"crossref","first-page":"7414","DOI":"10.1007\/s12010-023-04453-6","article-title":"Establishment of sensitive sandwich-type chemiluminescence immunoassay for interleukin-18 in urinary samples","volume":"195","author":"Fu","year":"2023","journal-title":"Appl Biochem Biotechnol"},{"key":"10.1016\/bs.acc.2026.01.006_bib115","doi-asserted-by":"crossref","first-page":"268","DOI":"10.4062\/biomolther.2012.20.3.268","article-title":"Drug-induced nephrotoxicity and its biomarkers","volume":"20","author":"Kim","year":"2012","journal-title":"Biomol Ther (Seoul)"},{"key":"10.1016\/bs.acc.2026.01.006_bib116","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7657876","article-title":"The influence of clusterin glycosylation variability on selected pathophysiological processes in the human body","volume":"2022","author":"Janiszewska","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/bs.acc.2026.01.006_bib117","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1681\/ASN.2011010048","article-title":"Clusterin attenuates the development of renal fibrosis","volume":"23","author":"Jung","year":"2012","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"10.1016\/bs.acc.2026.01.006_bib118","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.113","article-title":"Clusterin facilitates apoptotic cell clearance and prevents apoptotic cell-induced autoimmune responses","volume":"7","author":"Cunin","year":"2016","journal-title":"Cell Death & Dis"},{"key":"10.1016\/bs.acc.2026.01.006_bib119","first-page":"677","article-title":"Increase in clusterin forms part of the stress response in Hodgkin\u2019s lymphoma","volume":"38","author":"Frazzi","year":"2011","journal-title":"Int J Oncol"},{"key":"10.1016\/bs.acc.2026.01.006_bib120","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3390\/antibiotics13060530","article-title":"Comparison of the impact of VRP-034 and polymyxin B upon markers of kidney injury in human proximal tubule monolayers in vitro","volume":"13","author":"Pye","year":"2024","journal-title":"Antibiotics"},{"key":"10.1016\/bs.acc.2026.01.006_bib121","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/j.clinbiochem.2012.04.024","article-title":"Clinical significance of serum clusterin as a biomarker for evaluating diagnosis and metastasis potential of viral-related hepatocellular carcinoma","volume":"45","author":"Nafee","year":"2012","journal-title":"Clin Biochem"},{"key":"10.1016\/bs.acc.2026.01.006_bib122","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.3349\/ymj.2021.62.11.1016","article-title":"Serum clusterin level could reflect the current activity of antineutrophil cytoplasmic antibody-associated vasculitis","volume":"62","author":"Yoon","year":"2021","journal-title":"Yonsei Med J"},{"key":"10.1016\/bs.acc.2026.01.006_bib123","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/168960","article-title":"Serum clusterin as a tumor marker and prognostic factor for patients with esophageal cancer","volume":"2014","author":"Guo","year":"2014","journal-title":"Dis Markers"},{"key":"10.1016\/bs.acc.2026.01.006_bib124","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.taap.2019.01.012","article-title":"A multiplexed UPLC-MS\/MS assay for the simultaneous measurement of urinary safety biomarkers of drug-induced kidney injury and phospholipidosis","volume":"366","author":"Tengstrand","year":"2019","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/bs.acc.2026.01.006_bib125","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/FTD.0000000000000589","article-title":"Biomarkers of drug-induced kidney toxicity","volume":"41","author":"Griffin","year":"2019","journal-title":"Ther Drug Monit"},{"key":"10.1016\/bs.acc.2026.01.006_bib126","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/toxsci\/kfae088","article-title":"Qualified kidney injury biomarkers demonstrate value during early clinical drug development","volume":"201","author":"Ravindra","year":"2024","journal-title":"Toxicological Sci"},{"key":"10.1016\/bs.acc.2026.01.006_bib127","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2020.152462","article-title":"Urine kidney safety biomarkers improve understanding of indirect intra-renal injury potential in dogs with a drug-induced prerenal azotemia","volume":"439","author":"Gu","year":"2020","journal-title":"Toxicology"},{"key":"10.1016\/bs.acc.2026.01.006_bib128","doi-asserted-by":"crossref","first-page":"308","DOI":"10.3390\/s18010308","article-title":"Development of a label-free immunosensor for clusterin detection as an Alzheimer\u2019s biomarker","volume":"18","author":"Islam","year":"2018","journal-title":"Sensors"},{"key":"10.1016\/bs.acc.2026.01.006_bib129","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1177\/0004563213503456","article-title":"Quantification of clusterin in paired cerebrospinal fluid and plasma samples","volume":"51","author":"Jongbloed","year":"2014","journal-title":"Ann Clin Biochem"},{"key":"10.1016\/bs.acc.2026.01.006_bib130","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1093\/ndt\/gfac173","article-title":"Association of osteopontin with kidney function and kidney failure in chronic kidney disease patients: the GCKD study","volume":"38","author":"Steinbrenner","year":"2023","journal-title":"Nephrology Dialysis Transplant"},{"key":"10.1016\/bs.acc.2026.01.006_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102533","article-title":"Calcinosis biomarkers in adult and juvenile dermatomyositis","volume":"19","author":"Chung","year":"2020","journal-title":"Autoimmun Rev"},{"key":"10.1016\/bs.acc.2026.01.006_bib132","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2024.115928","article-title":"Assessment of osteopontin as an early nephrotoxicity indicator in human renal proximal tubule cells and its application in evaluating lanthanum-induced nephrotoxicity","volume":"271","author":"Chen","year":"2024","journal-title":"Ecotoxicol Env Saf"},{"key":"10.1016\/bs.acc.2026.01.006_bib133","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1464-410X.2009.08374.x","article-title":"Superoxide from NADPH oxidase as second messenger for the expression of osteopontin and monocyte chemoattractant protein-1 in renal epithelial cells exposed to calcium oxalate crystals","volume":"104","author":"Umekawa","year":"2009","journal-title":"BJU Int"},{"key":"10.1016\/bs.acc.2026.01.006_bib134","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/ki.2009.90","article-title":"Osteopontin modulates angiotensin II-induced inflammation, oxidative stress, and fibrosis of the kidney","volume":"76","author":"Wolak","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/bs.acc.2026.01.006_bib135","article-title":"High levels of circulating osteopontin in inflammatory lung disease regardless of Sars-CoV-2 infection","volume":"13","author":"Cappellano","year":"2021","journal-title":"EMBO Mol Med"},{"key":"10.1016\/bs.acc.2026.01.006_bib136","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000035137","article-title":"Osteopontin as an early predictor of atherosclerosis in attack-free familial mediterranean fever patients","volume":"102","author":"Baspinar","year":"2023","journal-title":"Medicine"},{"key":"10.1016\/bs.acc.2026.01.006_bib137","doi-asserted-by":"crossref","first-page":"58","DOI":"10.14715\/cmb\/2023.69.5.10","article-title":"Influence mechanism of osteopontin on renal injury in patients with hereditary hypercalcemia by enzyme-linked immunosorbent assay","volume":"69","author":"Peng","year":"2023","journal-title":"Cell Mol Biol"},{"key":"10.1016\/bs.acc.2026.01.006_bib138","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0281491","article-title":"A targeted isotope dilution mass spectrometry assay for osteopontin quantification in plasma of metastatic breast cancer patients","volume":"18","author":"Leslie","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/bs.acc.2026.01.006_bib139","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1420862","article-title":"The multifaceted role of insulin-like growth factor binding protein 7","volume":"12","author":"Chen","year":"2024","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/bs.acc.2026.01.006_bib140","doi-asserted-by":"crossref","first-page":"6529","DOI":"10.3390\/ijms21186529","article-title":"Characterization of insulin-like growth factor binding protein 7 (Igfbp7) and its potential involvement in shell formation and metamorphosis of pacific abalone, haliotis discus hannai","volume":"21","author":"Sharker","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/bs.acc.2026.01.006_bib141","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/j.kint.2022.05.026","article-title":"Insulin-like growth factor binding protein 7 promotes acute kidney injury by alleviating poly ADP ribose polymerase 1 degradation","volume":"102","author":"Tao Yu","year":"2022","journal-title":"Kidney Int"},{"key":"10.1016\/bs.acc.2026.01.006_bib142","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2174\/1389200223666220425111931","article-title":"Elevated urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor binding protein-7 predict drug-induced acute kidney injury","volume":"23","author":"Akalya","year":"2022","journal-title":"Curr Drug Metab"},{"key":"10.1016\/bs.acc.2026.01.006_bib143","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/CCM.0000000000002847","article-title":"Kinetics of urinary cell cycle arrest markers for acute kidney injury following exposure to potential renal insults","volume":"46","author":"Ostermann","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/bs.acc.2026.01.006_bib144","article-title":"Serum IGFBP7 levels associate with insulin resistance and the risk of metabolic syndrome in a Chinese population","volume":"5","author":"Liu","year":"2015","journal-title":"Sci Rep"},{"key":"10.1016\/bs.acc.2026.01.006_bib145","doi-asserted-by":"crossref","first-page":"210","DOI":"10.2337\/dc20-1889","article-title":"Insulin-like growth factor binding protein 7 predicts renal and cardiovascular outcomes in the canagliflozin cardiovascular assessment study","volume":"44","author":"Januzzi","year":"2021","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.acc.2026.01.006_bib146","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jchf.2022.09.004","article-title":"IGFBP-7 and outcomes in heart failure with reduced ejection fraction","volume":"11","author":"Adamson","year":"2023","journal-title":"Find DAPA-HF, JACC Heart Fail"},{"key":"10.1016\/bs.acc.2026.01.006_bib147","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1038\/ki.2013.363","article-title":"Identification of IGFBP-7 by urinary proteomics as a novel prognostic marker in early acute kidney injury","volume":"85","author":"Aregger","year":"2014","journal-title":"Kidney Int"},{"key":"10.1016\/bs.acc.2026.01.006_bib148","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.2174\/0929867329666220823112731","article-title":"Physiological properties, functions, and trends in the matrix metalloproteinase inhibitors in inflammation-mediated human diseases","volume":"30","author":"Kim","year":"2023","journal-title":"Curr Med Chem"},{"key":"10.1016\/bs.acc.2026.01.006_bib149","first-page":"251","article-title":"Tissue inhibitor metalloproteinase-2\u00b7IGF-binding protein 7 for the prediction of acute kidney injury following cardiac surgery","volume":"14","author":"Xie","year":"2024","journal-title":"Cardiorenal Med"},{"key":"10.1016\/bs.acc.2026.01.006_bib150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0311755","article-title":"The efficacy of novel biomarkers for the early detection and management of acute kidney injury: a systematic review","volume":"20","author":"Yousef Almulhim","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/bs.acc.2026.01.006_bib151","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/apha.12764","article-title":"Biomarkers in acute kidney injury\u2013pathophysiological basis and clinical performance","volume":"219","author":"Schrezenmeier","year":"2017","journal-title":"Acta Physiologica"},{"key":"10.1016\/bs.acc.2026.01.006_bib152","doi-asserted-by":"crossref","first-page":"3494","DOI":"10.3390\/ijms23073494","article-title":"The urinary level of injury biomarkers is not univocally reflective of the extent of toxic renal tubular injury in rats","volume":"23","author":"Sancho-Mart\u00ednez","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/bs.acc.2026.01.006_bib153","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/10408363.2021.1879000","article-title":"Current concepts and advances in biomarkers of acute kidney injury","volume":"58","author":"Wen","year":"2021","journal-title":"Crit Rev Clin Lab Sci"},{"key":"10.1016\/bs.acc.2026.01.006_bib154","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/bit.28029","article-title":"Biogenesis and mechanisms of microRNA-mediated gene regulation","volume":"119","author":"Rani","year":"2022","journal-title":"Biotechnol Bioeng"},{"key":"10.1016\/bs.acc.2026.01.006_bib155","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202401834R","article-title":"MiR-21 suppression in macrophages promotes M2-like polarization and attenuates kidney ischemia-reperfusion injury","volume":"38","author":"Wang","year":"2024","journal-title":"FASEB J"},{"key":"10.1016\/bs.acc.2026.01.006_bib156","doi-asserted-by":"crossref","DOI":"10.1172\/JCI171431","article-title":"Biomarkers in acute kidney injury: on the cusp of a new era?","volume":"133","author":"Canney","year":"2023","journal-title":"J Clin Investig"},{"key":"10.1016\/bs.acc.2026.01.006_bib157","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1007\/s10753-024-01993-9","article-title":"Combined plasma olink proteomics and transcriptomics identifies CXCL1 and TNFRSF12A as potential predictive and diagnostic inflammatory markers for acute kidney injury","volume":"47","author":"Li","year":"2024","journal-title":"Inflammation"},{"key":"10.1016\/bs.acc.2026.01.006_bib158","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.bcp.2012.12.019","article-title":"Urinary chemokine (C-C motif) ligand 2 (monocyte chemotactic protein-1) as a tubular injury marker for early detection of cisplatin-induced nephrotoxicity","volume":"85","author":"Nishihara","year":"2013","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/bs.acc.2026.01.006_bib159","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000033202","article-title":"Association of beta-2-microglobulin with cardiovascular and all-cause mortality in the general and non-CKD population","volume":"102","author":"Fang","year":"2023","journal-title":"Medicine"},{"key":"10.1016\/bs.acc.2026.01.006_bib160","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1177\/0192623320985045","article-title":"A review of specific biomarkers of chronic renal injury and their potential application in nonclinical safety assessment studies","volume":"49","author":"Obert","year":"2021","journal-title":"Toxicol Pathol"},{"issue":"1","key":"10.1016\/bs.acc.2026.01.006_bib161","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s43162-024-00341-5","article-title":"Genomic insights into renal diseases: advancements and implications","volume":"36","author":"Aderinto","year":"2024","journal-title":"Egypt J Intern Med"},{"key":"10.1016\/bs.acc.2026.01.006_bib162","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23137108","article-title":"Are alterations in DNA methylation related to CKD development?","volume":"23","author":"Rysz","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/bs.acc.2026.01.006_bib163","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1096\/fj.201800205R","article-title":"DNA methylation and the potential role of demethylating agents in prevention of progressive chronic kidney disease","volume":"32","author":"Larkin","year":"2018","journal-title":"FASEB J"},{"key":"10.1016\/bs.acc.2026.01.006_bib164","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/ndt\/gfy009","article-title":"Targeting epigenetic DNA and histone modifications to treat kidney disease","volume":"33","author":"Fontecha-Barriuso","year":"2018","journal-title":"Nephrol Dial Transpl"},{"key":"10.1016\/bs.acc.2026.01.006_bib165","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1093\/toxsci\/kfg068","article-title":"A correlation between a proteomic evaluation and conventional measurements in the assessment of renal proximal tubular toxicity","volume":"73","author":"Bandara","year":"2003","journal-title":"Toxicol Sci"},{"key":"10.1016\/bs.acc.2026.01.006_bib166","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.581300","article-title":"DAMPs in unilateral ureteral obstruction","volume":"11","author":"Wyczanska","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/bs.acc.2026.01.006_bib167","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/hep.28493","article-title":"Keratins: biomarkers and modulators of apoptotic and necrotic cell death in the liver","volume":"64","author":"Ku","year":"2016","journal-title":"Hepatology"},{"key":"10.1016\/bs.acc.2026.01.006_bib168","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.cca.2017.06.005","article-title":"The diagnostic value of rescaled renal biomarkers serum creatinine and serum cystatin C and their relation with measured glomerular filtration rate","volume":"471","author":"Pottel","year":"2017","journal-title":"Clinica Chim Acta"},{"key":"10.1016\/bs.acc.2026.01.006_bib169","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1053\/j.ajkd.2022.09.010","article-title":"Association of the urine-to-plasma urea ratio with CKD progression","volume":"81","author":"Liu","year":"2023","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/bs.acc.2026.01.006_bib170","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1080\/14737159.2020.1768849","article-title":"Cystatin C as a biomarker of chronic kidney disease: latest developments","volume":"20","author":"Benoit","year":"2020","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/bs.acc.2026.01.006_bib171","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13479","article-title":"Biomarkers and predicting acute kidney injury","volume":"231","author":"Luft","year":"2021","journal-title":"Acta Physiologica"},{"key":"10.1016\/bs.acc.2026.01.006_bib172","first-page":"15","article-title":"Neutrophil gelatinase associated lipocalin (NGAL) \u2013 a biomarker of renal dysfunction in patients with liver cirrhosis: do we have enough proof?","volume":"8","author":"Firu","year":"2015","journal-title":"J Med Life"},{"key":"10.1016\/bs.acc.2026.01.006_bib173","doi-asserted-by":"crossref","first-page":"27","DOI":"10.29328\/journal.jcn.1001056","article-title":"Biomarkers in acute kidney injury","volume":"4","author":"Nehomar","year":"2020","journal-title":"J Clin Nephrol"},{"issue":"1","key":"10.1016\/bs.acc.2026.01.006_bib174","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-023-47418-9","article-title":"A novel multiplex biomarker panel for profiling human acute and chronic kidney disease","volume":"13","author":"Van Nynatten","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/bs.acc.2026.01.006_bib175","first-page":"563","article-title":"New perspectives of drug related kidney diseases and disorders","volume":"30","author":"Kane-Gill","year":"2024","journal-title":"Curr Opin Crit Care"},{"key":"10.1016\/bs.acc.2026.01.006_bib176","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1111\/all.16576","article-title":"Endotypes in immune mediated drug reactions: present and future of relevant biomarkers. An EAACi task force report","volume":"80","author":"Mayorga","year":"2025","journal-title":"Allergy"},{"key":"10.1016\/bs.acc.2026.01.006_bib177","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.148","article-title":"Evaluation of biomarkers for in vitro prediction of drug-induced nephrotoxicity: comparison of HK-2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cells","volume":"3","author":"Huang","year":"2015","journal-title":"Pharmacol Res Perspect"},{"key":"10.1016\/bs.acc.2026.01.006_bib178","unstructured":"Critical Path Institute. FDA accepts qualification plan for urine biomarker panel to allow earlier detection of response to drug-induced kidney injury in clinical trials.\u00a0Critical Path Institute; 2024 Feb 15. Available from: https:\/\/c-path.org\/fda-accepts-qualification-plan-for-urine-biomarker-panel-to-allow-earlier-detection-of-response-to-drug-induced-kidney-injury-in-clinical-trials\/, (n.d.)."},{"key":"10.1016\/bs.acc.2026.01.006_bib179","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cotox.2020.06.001","article-title":"The regulatory acceptance of translational safety biomarkers","volume":"23\u201324","author":"Sauer","year":"2020","journal-title":"Curr Opin Toxicol"},{"key":"10.1016\/bs.acc.2026.01.006_bib180","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s00134-018-5126-8","article-title":"Biomarkers for prediction of renal replacement therapy in acute kidney injury: a systematic review and meta-analysis","volume":"44","author":"Klein","year":"2018","journal-title":"Intensive Care Med"},{"key":"10.1016\/bs.acc.2026.01.006_bib181","doi-asserted-by":"crossref","DOI":"10.3390\/biom14010082","article-title":"Toward precision medicine: exploring the landscape of biomarkers in acute kidney injury","volume":"14","author":"Nourie","year":"2024","journal-title":"Biomolecules"},{"key":"10.1016\/bs.acc.2026.01.006_bib182","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1177\/10600280221117993","article-title":"Interventions, barriers, and proposed solutions associated with the implementation of a protocol that uses clinical decision support and a stress biomarker test to identify ICU patients at high-risk for drug associated acute kidney injury","volume":"57","author":"Williams","year":"2023","journal-title":"Ann Pharmacother"},{"key":"10.1016\/bs.acc.2026.01.006_bib183","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2215\/CJN.07420619","article-title":"Proteomics and metabolomics in kidney disease, including insights into etiology, treatment, and prevention","volume":"15","author":"Dubin","year":"2019","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/bs.acc.2026.01.006_bib184","doi-asserted-by":"crossref","DOI":"10.3390\/genes12111687","article-title":"UMOD polymorphisms associated with kidney function, serum uromodulin and risk of mortality among patients with chronic kidney disease, results from the C-STRIDE study","volume":"12","author":"Wang","year":"2021","journal-title":"Genes (Basel)"},{"key":"10.1016\/bs.acc.2026.01.006_bib185","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1681\/ASN.0000000000000066","article-title":"Novel genetic variants associated with chronic kidney disease progression","volume":"34","author":"Han","year":"2023","journal-title":"J Am Soc Nephrol"}],"container-title":["Advances in Clinical Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S006524232600020X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S006524232600020X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T08:05:27Z","timestamp":1779955527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S006524232600020X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443470981"],"references-count":185,"URL":"https:\/\/doi.org\/10.1016\/bs.acc.2026.01.006","relation":{},"ISSN":["0065-2423"],"issn-type":[{"value":"0065-2423","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}