{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:12:02Z","timestamp":1791267122838,"version":"4.1.0"},"reference-count":76,"publisher":"Elsevier","isbn-type":[{"value":"9780443428258","type":"print"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/bs.accb.2025.09.003","type":"book-chapter","created":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T21:45:38Z","timestamp":1762206338000},"page":"111-167","source":"Crossref","is-referenced-by-count":2,"title":["Carbohydrate-modified carbonic anhydrase inhibitors: Advances and challenges"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.accb.2025.09.003_bib1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/14656566.2025.2474574","article-title":"Polypharmacology of Carbonic Anhydrase Inhibitors and Activators","volume":"26","author":"Bonardi","year":"2025","journal-title":"Expert. Opin. Pharmacother."},{"key":"10.1016\/bs.accb.2025.09.003_bib2","doi-asserted-by":"crossref","DOI":"10.1124\/pharmrev.124.001125","article-title":"Multi- and Polypharmacology of Carbonic Anhydrase Inhibitors","volume":"77","author":"Supuran","year":"2025","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/bs.accb.2025.09.003_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108224","article-title":"Carbonic Anhydrase Inhibitors: Structural Insights and Therapeutic Potential","volume":"156","author":"Singh","year":"2025","journal-title":"Bioorg. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1021\/acs.chemrev.4c00278","article-title":"Multiple Binding Modes of Inhibitors to Human Carbonic Anhydrases: An Update on the Design of Isoform-Specific Modulators of Activity","volume":"125","author":"D\u2019Ambrosio","year":"2025","journal-title":"Chem. Rev."},{"key":"10.1016\/bs.accb.2025.09.003_bib5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/bs.enz.2024.05.006","article-title":"Challenges for Developing Bacterial CA Inhibitors as Novel Antibiotics","volume":"55","author":"Supuran","year":"2024","journal-title":"Enzymes"},{"key":"10.1016\/bs.accb.2025.09.003_bib6","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1080\/14728222.2023.2263914","article-title":"An Overview of Novel Antimicrobial Carbonic Anhydrase Inhibitors","volume":"27","author":"Supuran","year":"2023","journal-title":"Expert. Opin. Ther. Targets"},{"key":"10.1016\/bs.accb.2025.09.003_bib7","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1080\/14756366.2020.1755852","article-title":"Bacterial I-Carbonic Anhydrase: A New Active Class of Carbonic Anhydrase Identified in the Genome of the Gram-Negative Bacterium Burkholderia Territorii","volume":"35","author":"Del Prete","year":"2020","journal-title":"J. Enzyme Inhib. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/bs.enz.2024.05.003","article-title":"Bacterial \u03b9-CAs","volume":"55","author":"Capasso","year":"2024","journal-title":"Enzymes"},{"key":"10.1016\/bs.accb.2025.09.003_bib9","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1080\/17460441.2021.1922384","article-title":"Advances in the Discovery of Novel Agents for the Treatment of Glaucoma","volume":"16","author":"Mincione","year":"2021","journal-title":"Expert. Opin. Drug. Discov."},{"key":"10.1016\/bs.accb.2025.09.003_bib10","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.3390\/biom10091307","article-title":"Effects of New NSAID-CAI Hybrid Compounds in Inflammation and Lung Fibrosis","volume":"10","author":"Lucarini","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/bs.accb.2025.09.003_bib11","doi-asserted-by":"crossref","first-page":"48","DOI":"10.3390\/metabo7030048","article-title":"Carbonic Anhydrase Inhibition and the Management of Hypoxic Tumors","volume":"7","author":"Supuran","year":"2017","journal-title":"Metabolites"},{"key":"10.1016\/bs.accb.2025.09.003_bib12","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1021\/acs.jmedchem.4c00045","article-title":"Dual Inhibitors of Brain Carbonic Anhydrases and Monoamine Oxidase-B Efficiently Protect Against Amyloid-\u03b2-Induced Neuronal Toxicity, Oxidative Stress, and Mitochondrial Dysfunction","volume":"67","author":"Giovannuzzi","year":"2024","journal-title":"J. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib13","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1517\/17460441.2015.1038235","article-title":"Designing Carbonic Anhydrase Inhibitors for the Treatment of Breast Cancer","volume":"10","author":"Supuran","year":"2015","journal-title":"Expert. Opin. Drug. Discov."},{"key":"10.1016\/bs.accb.2025.09.003_bib14","doi-asserted-by":"crossref","first-page":"2366236","DOI":"10.1080\/14756366.2024.2366236","article-title":"Development of a Multi-Targeted Chemotherapeutic Approach Based on G-Quadruplex Stabilisation and Carbonic Anhydrase Inhibition","volume":"39","author":"Nocentini","year":"2024","journal-title":"J. Enzyme Inhib. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib15","doi-asserted-by":"crossref","first-page":"15151","DOI":"10.1021\/acs.jmedchem.5c01392","article-title":"Design, Synthesis, and In Vitro Anticancer Evaluation of Thiazole-Based Chalcones Linked to Sulfanilamide as Tumor-Associated Carbonic Anhydrase IX and XII Inhibitors","volume":"68","author":"Elshamsy","year":"2025","journal-title":"J. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib16","doi-asserted-by":"crossref","first-page":"18221","DOI":"10.1021\/acs.jmedchem.4c01516","article-title":"Benzoxaborinine, New Chemotype for Carbonic Anhydrase Inhibition: Ex Novo Synthesis, Crystallography, In Silico Studies, and Anti-Melanoma Cell Line Activity","volume":"67","author":"Giovannuzzi","year":"2024","journal-title":"J. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib17","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1080\/14756366.2021.1945049","article-title":"Multitargeting Approaches Involving Carbonic Anhydrase Inhibitors: Hybrid Drugs Against a Variety of Disorders","volume":"36","author":"Supuran","year":"2021","journal-title":"J. Enzyme Inhib. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2022.105920","article-title":"A Decade of Tail-Approach Based Design of Selective as Well as Potent Tumor Associated Carbonic Anhydrase Inhibitors","volume":"126","author":"Kumar","year":"2022","journal-title":"Bioorg. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106976","article-title":"Boron-Containing Carbonic Anhydrases Inhibitors","volume":"143","author":"Giovannuzzi","year":"2024","journal-title":"Bioorg. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib20","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1021\/acsomega.2c07459","article-title":"Tail-Approach-Based Design and Synthesis of Coumarin-Monoterpenes as Carbonic Anhydrase Inhibitors and Anticancer Agents","volume":"8","author":"Zengin Kurt","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/bs.accb.2025.09.003_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2017.03.023","article-title":"Dual-Tail Approach to Discovery of Novel Carbonic Anhydrase IX Inhibitors by Simultaneously Matching the Hydrophobic and Hydrophilic Halves of the Active Site","volume":"132","author":"Hou","year":"2017","journal-title":"Eur. J. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib22","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3390\/ijms23010461","article-title":"Aromatic Sulfonamides Including a Sulfonic Acid Tail: New Membrane Impermeant Carbonic Anhydrase Inhibitors for Targeting Selectively the Cancer-Associated Isoforms","volume":"23","author":"Giovannuzzi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/bs.accb.2025.09.003_bib23","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.3109\/14756366.2016.1156104","article-title":"Synthesis of Some Tetrahydropyrimidine-5-Carboxylates, Determination of Their Metal Chelating Effects and Inhibition Profiles Against Acetylcholinesterase, Butyrylcholinesterase and Carbonic Anhydrase","volume":"31","author":"Sujayev","year":"2016","journal-title":"J. Enzyme Inhib. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib24","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1002\/med.20141","article-title":"Therapeutic Applications of Glycosidic Carbonic Anhydrase Inhibitors","volume":"29","author":"Winum","year":"2009","journal-title":"Med. Res. Rev."},{"key":"10.1016\/bs.accb.2025.09.003_bib25","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1021\/acsmedchemlett.9b00590","article-title":"Glycomimetic Based Approach Toward Selective Carbonic Anhydrase Inhibitors","volume":"11","author":"Pratesi","year":"2020","journal-title":"ACS Med. Chem. Lett"},{"key":"10.1016\/bs.accb.2025.09.003_bib26","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.bmc.2012.10.043","article-title":"Glycosidic Carbonic Anhydrase IX Inhibitors: A Sweet Approach Against Cancer","volume":"21","author":"Winum","year":"2013","journal-title":"Bioorg. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib27","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1080\/14756366.2020.1825409","article-title":"An Overview of Carbohydrate-Based Carbonic Anhydrase Inhibitors","volume":"35","author":"Cuffaro","year":"2020","journal-title":"J. Enzyme Inhib. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib28","doi-asserted-by":"crossref","first-page":"6421","DOI":"10.1021\/jm900914e","article-title":"S-Glycosyl Primary Sulfonamides--A New Structural Class for Selective Inhibition of Cancer-Associated Carbonic Anhydrases","volume":"52","author":"Lopez","year":"2009","journal-title":"J. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib29","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1021\/ol035838g","article-title":"A Novel Sulfonamidoglycosylation of Glycals","volume":"5","author":"Colinas","year":"2003","journal-title":"Org. Lett."},{"key":"10.1016\/bs.accb.2025.09.003_bib30","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.tetlet.2005.01.065","article-title":"Sulfonamidoglycosylation of Methyl Ribofuranosides: A Novel Approach to Furanosylsulfonamides","volume":"46","author":"Colinas","year":"2005","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/bs.accb.2025.09.003_bib31","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1080\/07328300802030829","article-title":"Sulfonamidoglycosylation of Methyl Glycosides Employing Perchloric Acid Supported on Silica Gel","volume":"27","author":"Colinas","year":"2008","journal-title":"J. Carbohydr. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib32","first-page":"4143","article-title":"Stereoselective Synthesis of Novel N-\u03b2-Glycosyl Sulfonamides by Sulfonamidoglycosylation of Per-O-Acetylated Sugars","volume":"24","author":"Colinas","year":"2009","journal-title":"Synthesis"},{"key":"10.1016\/bs.accb.2025.09.003_bib33","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1016\/j.bmcl.2007.07.023","article-title":"Carbonic Anhydrase Inhibitors. Inhibition of Cytosolic Isoforms I and II, and Extracellular Isoforms IV, IX, and XII with Sulfamides Incorporating Sugar Moieties","volume":"17","author":"Colinas","year":"2007","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/bs.accb.2025.09.003_bib34","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1016\/j.bmcl.2011.06.031","article-title":"N-\u03b2-Glycosyl Sulfamides are Selective Inhibitors of the Cancer Associated Carbonic Anhydrase Isoforms IX and XII","volume":"21","author":"Rodr\u00edguez","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/bs.accb.2025.09.003_bib35","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.1016\/j.bmc.2014.09.053","article-title":"Ferrier Sulfamidoglycosylation of Glycals Catalyzed by Nitrosonium Tetrafluoroborate: Towards New Carbonic Anhydrase Glycoinhibitors","volume":"22","author":"Ombouma","year":"2014","journal-title":"Bioorg. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib36","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1021\/acsmedchemlett.5b00175","article-title":"Carbonic Anhydrase Glycoinhibitors Belonging to the Aminoxysulfonamide Series","volume":"6","author":"Ombouma","year":"2015","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/bs.accb.2025.09.003_bib37","doi-asserted-by":"crossref","first-page":"10","DOI":"10.2174\/138955708783331568","article-title":"Topiramate: Its Pharmacological Properties and Therapeutic Efficacy in Epilepsy","volume":"8","author":"Latini","year":"2008","journal-title":"Mini Rev. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib38","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0960-894X(03)00029-5","article-title":"Carbonic Anhydrase Inhibitors: Sar and X-ray Crystallographic Study for the Interaction of Sugar Sulfamates\/Sulfamides with Isozymes I, II and IV","volume":"13","author":"Casini","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/bs.accb.2025.09.003_bib39","doi-asserted-by":"crossref","first-page":"7024","DOI":"10.1021\/jm060807n","article-title":"Carbonic Anhydrase Inhibitors: Clash with Ala65 as a Means for Designing Inhibitors with Low Affinity for the Ubiquitous Isozyme II, Exemplified by the Crystal Structure of the Topiramate Sulfamide Analogue","volume":"49","author":"Winum","year":"2006","journal-title":"J. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib40","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1042\/bj3610437","article-title":"Crystal Structure of Human Carbonic Anhydrase II Complexed with an Anti-Convulsant Sugar Sulphamate","volume":"361","author":"Recacha","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/bs.accb.2025.09.003_bib41","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1021\/jm101525j","article-title":"Design, Synthesis, and Biological Evaluation of Novel Carbohydrate-Based Sulfamates as Carbonic Anhydrase Inhibitors","volume":"54","author":"Lopez","year":"2011","journal-title":"J. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib42","doi-asserted-by":"crossref","first-page":"18452","DOI":"10.1021\/ja207855c","article-title":"Promiscuity of Carbonic Anhydrase II. Unexpected Ester Hydrolysis of Carbohydrate-Based Sulfamate Inhibitors","volume":"133","author":"Lopez","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/bs.accb.2025.09.003_bib43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.bmcl.2003.09.063","article-title":"Carbonic Anhydrase Inhibitors: N-(p-Sulfamoylphenyl)-Alpha-D-Glycopyranosylamines as Topically Acting Antiglaucoma Agents in Hypertensive Rabbits","volume":"14","author":"Winum","year":"2004","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/bs.accb.2025.09.003_bib44","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.1021\/jm060967z","article-title":"A Novel Class of Carbonic Anhydrase Inhibitors: Glycoconjugate Benzene Sulfonamides Prepared by \"click-tailing\"","volume":"49","author":"Wilkinson","year":"2006","journal-title":"J. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib45","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.bmcl.2006.11.046","article-title":"Inhibition of Membrane-Associated Carbonic Anhydrase Isozymes IX, XII and XIV with a Library of Glycoconjugate Benzene Sulfonamides","volume":"17","author":"Moeker","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/bs.accb.2025.09.003_bib46","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1021\/jm061320h","article-title":"Carbonic Anhydrase Inhibitors: Inhibition of Isozymes I, II, and IX with Triazole-Linked O-Glycosides of Benzene Sulfonamides","volume":"50","author":"Wilkinson","year":"2007","journal-title":"J. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib47","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1021\/jm701426t","article-title":"Inhibition of Carbonic Anhydrases with Glycosyltriazole Benzene Sulfonamides","volume":"51","author":"Wilkinson","year":"2008","journal-title":"J. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib48","doi-asserted-by":"crossref","first-page":"9623","DOI":"10.1021\/jm401163e","article-title":"A Prodrug Approach Toward Cancer-Related Carbonic Anhydrase Inhibition","volume":"56","author":"Carroux","year":"2013","journal-title":"J. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib49","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1016\/j.bmcl.2011.08.066","article-title":"Synthesis of Glycoconjugate Carbonic Anhydrase Inhibitors by Ruthenium-Catalysed Azide-Alkyne 1,3-Dipolar Cycloaddition","volume":"21","author":"Salmon","year":"2011","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/bs.accb.2025.09.003_bib50","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1016\/j.bmcl.2009.02.086","article-title":"Inhibition of Carbonic Anhydrase Isozymes with Benzene Sulfonamides Incorporating Thio, Sulfinyl and Sulfonyl Glycoside Moieties","volume":"19","author":"Singer","year":"2009","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/bs.accb.2025.09.003_bib51","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1021\/jm901888x","article-title":"Sulfonamide Linked Neoglycoconjugates\u2014a New Class of Inhibitors for Cancer-Associated Carbonic Anhydrases","volume":"53","author":"Lopez","year":"2010","journal-title":"J. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib52","doi-asserted-by":"crossref","first-page":"6905","DOI":"10.1021\/jm200892s","article-title":"Targeting Hypoxic Tumor Cell Viability with Carbohydrate-Based Carbonic Anhydrase IX and XII Inhibitors","volume":"54","author":"Morris","year":"2011","journal-title":"J. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2025.108857","article-title":"Studies on Azasugar-Based Sulfonamides: A New Class of Carbonic Anhydrase Inhibitors","author":"Pratesi","year":"2025","journal-title":"Bioorg. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib54","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1016\/j.bmcl.2007.03.008","article-title":"Carbonic Anhydrase Inhibitors: Inhibition of Isoforms I, II, IV, VA, VII, IX, and XIV with Sulfonamides Incorporating Fructopyranose-Thioureido Tails","volume":"17","author":"Winum","year":"2007","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/bs.accb.2025.09.003_bib55","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1016\/j.bmc.2012.01.052","article-title":"Design and Synthesis of Thiourea Compounds that Inhibit Transmembrane Anchored Carbonic Anhydrases","volume":"20","author":"Moeker","year":"2012","journal-title":"Bioorg. Med. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib56","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1039\/c3cc42541j","article-title":"Thiol-Ene Click Chemistry for the Synthesis of Highly Effective Glycosyl Sulfonamide Carbonic Anhydrase Inhibitors","volume":"49","author":"Saada","year":"2013","journal-title":"Chem. Commun."},{"key":"10.1016\/bs.accb.2025.09.003_bib57","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1021\/jm501798g","article-title":"Carbonic Anhydrase Inhibitors with Dual-Tail Moieties to Match the Hydrophobic and Hydrophilic Halves of the Carbonic Anhydrase Active Site","volume":"58","author":"Tanpure","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejmech.2017.03.023","article-title":"Dual-Tail Approach to Discovery of Novel Carbonic Anhydrase IX Inhibitors by Simultaneously Matching the Hydrophobic and Hydrophilic Halves of the Active Site","volume":"132","author":"Hou","year":"2017","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib59","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1080\/14756366.2019.1705293","article-title":"Design, Synthesis and Biological Evaluation of Carbohydrate-Based Sulphonamide Derivatives as Topical Antiglaucoma Agents Through Selective Inhibition of Carbonic Anhydrase II","volume":"35","author":"Hou","year":"2020","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib60","doi-asserted-by":"crossref","first-page":"4491","DOI":"10.1039\/D3OB00529A","article-title":"Mono- and Three-Tailed Sugar and Iminosugar Decorated Benzenesulfonamide Carbonic Anhydrase Inhibitors","volume":"21","author":"Davighi","year":"2023","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib61","doi-asserted-by":"crossref","first-page":"13028","DOI":"10.1038\/s41598-024-62864-9","article-title":"New Sulfonamide-Based Glycosides Incorporated 1,2,3-Triazole as Cytotoxic Agents Through VEGFR-2 and Carbonic Anhydrase Inhibitory Activity","volume":"14","author":"Abbas","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.accb.2025.09.003_bib62","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1021\/jm500255y","article-title":"Cyclic Secondary Sulfonamides: Unusually Good Inhibitors of Cancer-Related Carbonic Anhydrase Enzymes","volume":"57","author":"Moeker","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib63","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.bmc.2014.12.030","article-title":"Saccharin: A Lead Compound for Structure-Based Drug Design of Carbonic Anhydrase IX Inhibitors","volume":"23","author":"Mahon","year":"2015","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib64","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.carres.2019.03.001","article-title":"Synthesis of Saccharin-Glycoconjugates Targeting Carbonic Anhydrase Using a One-Pot Cyclization\/Deprotection Strategy","volume":"476","author":"Murray","year":"2019","journal-title":"Carbohydr. Res."},{"key":"10.1016\/bs.accb.2025.09.003_bib65","doi-asserted-by":"crossref","first-page":"8635","DOI":"10.1021\/jm5012935","article-title":"Structural Insights Into Carbonic Anhydrase IX Isoform Specificity of Carbohydrate-Based Sulfamates","volume":"57","author":"Moeker","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib66","doi-asserted-by":"crossref","first-page":"6630","DOI":"10.1021\/acs.jmedchem.5b00845","article-title":"Mapping Selective Inhibition of the Cancer-Related Carbonic Anhydrase IX Using Structure-Activity Relationships of Glucosyl-Based Sulfamates","volume":"58","author":"Mahon","year":"2015","journal-title":"J. Med. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib67","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bioorg.2017.10.020","article-title":"Improving the Carbonic Anhydrase Inhibition Profile of the Sulfamoylphenyl Pharmacophore by Attachment of Carbohydrate Moieties","volume":"76","author":"Riafrecha","year":"2018","journal-title":"Bioorg. Chem"},{"key":"10.1016\/bs.accb.2025.09.003_bib68","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1021\/jm200983e","article-title":"Glycosyl Coumarin Carbonic Anhydrase IX and XII Inhibitors Strongly Attenuate the Growth of Primary Breast Tumors","volume":"54","author":"Touisni","year":"2011","journal-title":"J. Med. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib69","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1016\/j.bmc.2014.07.052","article-title":"Attachment of Carbohydrates to Methoxyaryl Moieties Leads to Highly Selective Inhibitors of the Cancer Associated Carbonic Anhydrase Isoforms IX and XII","volume":"22","author":"Riafrecha","year":"2014","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib70","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.bmc.2012.09.002","article-title":"Synthesis of C-Cinnamoyl Glycosides and Their Inhibitory Activity Against Mammalian Carbonic Anhydrases","volume":"21","author":"Riafrecha","year":"2013","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib71","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1021\/acsmedchemlett.8b00100","article-title":"Sweet Binders: Carbonic Anhydrase IX in Complex with Sucralose","volume":"9","author":"Lomelino","year":"2018","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/bs.accb.2025.09.003_bib72","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.bmcl.2012.11.085","article-title":"Inhibition of the B-Carbonic Anhydrases from Mycobacterium Tuberculosis with C-Cinnamoyl Glycosides: Identification of the First Inhibitor with Anti-Mycobacterial Activity","volume":"23","author":"Buchieri","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/bs.accb.2025.09.003_bib73","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3109\/14756366.2014.986120","article-title":"Inhibition of B-Carbonic Anhydrases from Brucella Suis with C-Cinnamoyl Glycosides Incorporating the Phenol Moiety","volume":"30","author":"Riafrecha","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib74","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3109\/14756366.2014.967233","article-title":"C-Glycosides Incorporating the 6-Methoxy-2-Naphthyl Moiety are Selective Inhibitors of Fungal and Bacterial Carbonic Anhydrases","volume":"30","author":"Riafrecha","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib75","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.3109\/14756366.2014.986119","article-title":"N-Glycosyl-N-Hydroxysulfamides as Potent Inhibitors of Brucella Suis Carbonic Anhydrases","volume":"30","author":"Ombouma","year":"2015","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/bs.accb.2025.09.003_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.tips.2025.07.002","article-title":"Human Carbonic Anhydrase Modulators: The Past, Present, and Future","author":"Giovannuzzi","year":"2025","journal-title":"Trends Pharmacol. Sci."}],"container-title":["Advances in Carbohydrate Chemistry and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065231825000034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065231825000034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T13:01:51Z","timestamp":1763643711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065231825000034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9780443428258"],"references-count":76,"URL":"https:\/\/doi.org\/10.1016\/bs.accb.2025.09.003","relation":{},"ISSN":["0065-2318"],"issn-type":[{"value":"0065-2318","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}