{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:25:38Z","timestamp":1790393138414,"version":"4.1.0"},"reference-count":155,"publisher":"Elsevier","isbn-type":[{"value":"9780128149942","type":"print"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/bs.acr.2018.12.003","type":"book-chapter","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T18:39:45Z","timestamp":1547491185000},"page":"85-128","source":"Crossref","is-referenced-by-count":44,"title":["Clonal hematopoiesis: Pre-cancer PLUS"],"prefix":"10.1016","member":"78","reference":[{"issue":"2","key":"10.1016\/bs.acr.2018.12.003_bb0010","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ccr.2012.06.032","article-title":"ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression","volume":"22","author":"Abdel-Wahab","year":"2012","journal-title":"Cancer Cell"},{"issue":"7714","key":"10.1016\/bs.acr.2018.12.003_bb0015","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/s41586-018-0317-6","article-title":"Prediction of acute myeloid leukaemia risk in healthy individuals","volume":"559","author":"Abelson","year":"2018","journal-title":"Nature"},{"issue":"2","key":"10.1016\/bs.acr.2018.12.003_bb0020","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nm0296-190","article-title":"Evidence that hematopoiesis may be a stochastic process in vivo","volume":"2","author":"Abkowitz","year":"1996","journal-title":"Nature Medicine"},{"issue":"22","key":"10.1016\/bs.acr.2018.12.003_bb0025","doi-asserted-by":"crossref","first-page":"8366","DOI":"10.1073\/pnas.0308758101","article-title":"XL\u03b1s, the extra-long form of the \u03b1-subunit of the Gs G protein, is significantly longer than suspected, and so is its companion Alex","volume":"101","author":"Abramowitz","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.acr.2018.12.003_bb0030","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/s41375-018-0047-7","article-title":"Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis","volume":"32","author":"Arends","year":"2018","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/bs.acr.2018.12.003_bb0035","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.cancergen.2015.01.007","article-title":"Emergence of clonal hematopoiesis in the majority of patients with acquired aplastic anemia","volume":"208","author":"Babushok","year":"2015","journal-title":"Cancer Genetics"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0040","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jaci.2016.05.011","article-title":"Inflammatory mechanisms in patients with chronic obstructive pulmonary disease","volume":"138","author":"Barnes","year":"2016","journal-title":"Journal of Allergy and Clinical Immunology"},{"issue":"12","key":"10.1016\/bs.acr.2018.12.003_bb0045","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.1073\/pnas.1000834107","article-title":"Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion","volume":"107","author":"Beerman","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"10.1016\/bs.acr.2018.12.003_bb0050","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.stem.2013.01.017","article-title":"Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging","volume":"12","author":"Beerman","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0055","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/j.1460-2075.1994.tb06240.x","article-title":"Paroxysmal nocturnal haemoglobinuria (PNH) is caused by somatic mutations in the PIG-A gene","volume":"13","author":"Bessler","year":"1994","journal-title":"The EMBO Journal"},{"issue":"8","key":"10.1016\/bs.acr.2018.12.003_bb0060","doi-asserted-by":"crossref","first-page":"3118","DOI":"10.1182\/blood.V86.8.3118.3118","article-title":"Detection of major BCR-ABL gene expression at a very low level in blood cells of some healthy individuals","volume":"86","author":"Biernaux","year":"1995","journal-title":"Blood"},{"issue":"19","key":"10.1016\/bs.acr.2018.12.003_bb0065","doi-asserted-by":"crossref","first-page":"e182","DOI":"10.1182\/blood-2011-01-331926","article-title":"Genome-wide promoter DNA methylation dynamics of human hematopoietic progenitor cells during differentiation and aging","volume":"117","author":"Bocker","year":"2011","journal-title":"Blood"},{"key":"10.1016\/bs.acr.2018.12.003_bb0070","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/ng.2700","article-title":"Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications","volume":"45","author":"Bonnefond","year":"2013","journal-title":"Nature Genetics"},{"issue":"9","key":"10.1016\/bs.acr.2018.12.003_bb0075","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1182\/blood.V92.9.3362","article-title":"The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: Biologic significance and implications for the assessment of minimal residual disease","volume":"92","author":"Bose","year":"1998","journal-title":"Blood"},{"issue":"11","key":"10.1016\/bs.acr.2018.12.003_bb0080","doi-asserted-by":"crossref","first-page":"4216","DOI":"10.1210\/jc.2018-00803","article-title":"Radioactive iodine-related clonal hematopoiesis in thyroid cancer is common and associated with decreased survival","volume":"103","author":"Boucai","year":"2018","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"key":"10.1016\/bs.acr.2018.12.003_bb0085","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/leu.2010.20","article-title":"Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia","volume":"24","author":"Boultwood","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/bs.acr.2018.12.003_bb0090","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1182\/blood-2018-01-829937","article-title":"Lineage restriction analyses in CHIP indicate myeloid bias for TET2 and multipotent stem cell origin for DNMT3A","volume":"132","author":"Buscarlet","year":"2018","journal-title":"Blood"},{"issue":"6","key":"10.1016\/bs.acr.2018.12.003_bb0095","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1182\/blood-2017-04-777029","article-title":"DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions","volume":"130","author":"Buscarlet","year":"2017","journal-title":"Blood"},{"key":"10.1016\/bs.acr.2018.12.003_bb0100","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1002\/stem.2845","article-title":"Concise review: Age-related clonal hematopoiesis: Stem cells tempting the devil","volume":"36","author":"Busque","year":"2018","journal-title":"Stem Cells"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0105","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1182\/blood.V88.1.59.59","article-title":"Nonrandom X-inactivation patterns in normal females: Lyonization ratios vary with age","volume":"88","author":"Busque","year":"1996","journal-title":"Blood"},{"issue":"11","key":"10.1016\/bs.acr.2018.12.003_bb0110","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/ng.2413","article-title":"Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis","volume":"44","author":"Busque","year":"2012","journal-title":"Nature Genetics"},{"issue":"5043","key":"10.1016\/bs.acr.2018.12.003_bb0115","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1126\/science.1346476","article-title":"Modulation of activity of the promoter of the human MDR1 gene by Ras and p53","volume":"255","author":"Chin","year":"1992","journal-title":"Science"},{"issue":"26","key":"10.1016\/bs.acr.2018.12.003_bb0120","doi-asserted-by":"crossref","first-page":"17588","DOI":"10.1074\/jbc.M512616200","article-title":"Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor","volume":"281","author":"Cho","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"issue":"3","key":"10.1016\/bs.acr.2018.12.003_bb0125","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.stem.2017.07.010","article-title":"Therapy-related clonal hematopoiesis in patients with non-hematologic cancers is common and associated with adverse clinical outcomes","volume":"21","author":"Coombs","year":"2017","journal-title":"Cell Stem Cell"},{"issue":"7","key":"10.1016\/bs.acr.2018.12.003_bb0130","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1073\/pnas.1324297111","article-title":"Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission","volume":"111","author":"Corces-Zimmerman","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6963","key":"10.1016\/bs.acr.2018.12.003_bb0135","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nature02118","article-title":"A DNA damage checkpoint response in telomere-initiated senescence","volume":"426","author":"d'Adda di Fagagna","year":"2003","journal-title":"Nature"},{"key":"10.1016\/bs.acr.2018.12.003_bb0140","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature08448","article-title":"JAK2 phosphorylates histone H3Y41 and excludes HP1\u03b1 from chromatin","volume":"461","author":"Dawson","year":"2009","journal-title":"Nature"},{"issue":"22","key":"10.1016\/bs.acr.2018.12.003_bb0145","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1056\/NEJMoa0810069","article-title":"Mutation in TET2 in myeloid cancers","volume":"360","author":"Delhommeau","year":"2009","journal-title":"The New England Journal of Medicine"},{"issue":"7","key":"10.1016\/bs.acr.2018.12.003_bb0150","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1038\/s41591-018-0081-z","article-title":"Somatic mutations precede acute myeloid leukemia years before diagnosis","volume":"24","author":"Desai","year":"2018","journal-title":"Nature Medicine"},{"key":"10.1016\/bs.acr.2018.12.003_bb0155","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nri2925","article-title":"Type 2 diabetes as an inflammatory disease","volume":"11","author":"Donath","year":"2011","journal-title":"Nature Reviews Immunology"},{"issue":"S1","key":"10.1016\/bs.acr.2018.12.003_bb0160","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/ijlh.12361","article-title":"The utility of next-generation sequencing in diagnosis and monitoring of acute myeloid leukemia and myelodysplastic syndromes","volume":"37","author":"Duncavage","year":"2015","journal-title":"International Journal of Laboratory Hematology"},{"issue":"13","key":"10.1016\/bs.acr.2018.12.003_bb0165","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1084\/jem.20111490","article-title":"Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells","volume":"208","author":"Dykstra","year":"2011","journal-title":"The Journal of Experimental Medicine"},{"issue":"3","key":"10.1016\/bs.acr.2018.12.003_bb0170","first-page":"133","article-title":"Atherosclerosis and clonal hematopoiesis: A new risk factor","volume":"30","author":"Fern\u00e1ndez","year":"2018","journal-title":"Cl\u00ednica e Investigaci\u00f3n en Arteriosclerosis (English Edition)"},{"issue":"4","key":"10.1016\/bs.acr.2018.12.003_bb0175","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1182\/blood.V83.4.931.931","article-title":"Clonality and X-inactivation patterns in hematopoietic cell populations detected by the highly informative M27 beta DNA probe","volume":"83","author":"Fey","year":"1994","journal-title":"Blood"},{"issue":"7","key":"10.1016\/bs.acr.2018.12.003_bb0180","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1182\/blood.V77.7.1415.1415","article-title":"Clonal remissions in acute nonlymphocytic leukemia: Evidence for a multistep pathogenesis of the malignancy","volume":"77","author":"Fialkow","year":"1991","journal-title":"Blood"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM197907053010101","article-title":"Acute nonlymphocytic leukemia: Expression in cells restricted to granulocytic and monocytic differentiation","volume":"301","author":"Fialkow","year":"1979","journal-title":"The New England Journal of Medicine"},{"issue":"6","key":"10.1016\/bs.acr.2018.12.003_bb0190","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1182\/blood.V57.6.1068.bloodjournal5761068","article-title":"Acute nonlymphocytic leukemia: Heterogeneity of stem cell origin","volume":"57","author":"Fialkow","year":"1981","journal-title":"Blood"},{"issue":"12","key":"10.1016\/bs.acr.2018.12.003_bb0195","doi-asserted-by":"crossref","first-page":"6048","DOI":"10.1073\/pnas.94.12.6048","article-title":"Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependentmanner","volume":"94","author":"Fiscella","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.acr.2018.12.003_bb0200","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0378-1119(03)00430-X","article-title":"A human homolog of Additional sex combs, ADDITIONAL SEX COMBS-LIKE 1, maps to chromosome 20q11","volume":"306","author":"Fisher","year":"2003","journal-title":"Gene"},{"issue":"2","key":"10.1016\/bs.acr.2018.12.003_bb0205","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ajhg.2011.12.009","article-title":"Age-related somatic structural changes in the nuclear genome of human blood cells","volume":"90","author":"Forsberg","year":"2012","journal-title":"American Journal of Human Genetics"},{"issue":"6327","key":"10.1016\/bs.acr.2018.12.003_bb0210","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1126\/science.aag1381","article-title":"Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice","volume":"355","author":"Fuster","year":"2017","journal-title":"Science"},{"issue":"3","key":"10.1016\/bs.acr.2018.12.003_bb0215","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/CIRCRESAHA.117.312115","article-title":"Somatic mutations and clonal hematopoiesis: Unexpected potential new drivers of age-related cardiovascular disease","volume":"122","author":"Fuster","year":"2018","journal-title":"Circulation Research"},{"issue":"3","key":"10.1016\/bs.acr.2018.12.003_bb0220","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1046\/j.1365-2141.1997.2573078.x","article-title":"Acquired skewing of X-chromosome inactivation patterns in myeloid cells of the elderly suggests stochastic clonal loss with age","volume":"98","author":"Gale","year":"1997","journal-title":"British Journal of Haematology"},{"issue":"5","key":"10.1016\/bs.acr.2018.12.003_bb0225","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nri3433","article-title":"The ageing haematopoietic stem cell compartment","volume":"13","author":"Geiger","year":"2013","journal-title":"Nature Reviews Immunology"},{"issue":"26","key":"10.1016\/bs.acr.2018.12.003_bb0230","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1056\/NEJMoa1409405","article-title":"Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence","volume":"371","author":"Genovese","year":"2014","journal-title":"The New England Journal of Medicine"},{"issue":"14","key":"10.1016\/bs.acr.2018.12.003_bb0235","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1200\/JCO.2016.71.6712","article-title":"Clonal hematopoiesis associated with adverse outcomes after autologous stem-cell transplantation for lymphoma","volume":"35","author":"Gibson","year":"2017","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/bs.acr.2018.12.003_bb0240","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1158\/1078-0432.CCR-17-3044","article-title":"New insights from studies of clonal hematopoiesis","volume":"24","author":"Gibson","year":"2018","journal-title":"Clinical Cancer Research"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0245","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/S1470-2045(16)30627-1","article-title":"Clonal haemopoiesis and therapy-related myeloid malignancies in elderly patients: A proof-of-concept, case-control study","volume":"18","author":"Gillis","year":"2017","journal-title":"The Lancet Oncology"},{"issue":"5621","key":"10.1016\/bs.acr.2018.12.003_bb0250","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1126\/science.1084155","article-title":"Molecular architecture of the multiprotein splicing factor SF3b","volume":"300","author":"Golas","year":"2003","journal-title":"Science"},{"issue":"6","key":"10.1016\/bs.acr.2018.12.003_bb0255","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.trsl.2013.05.003","article-title":"Short telomeres: From dyskeratosis congenita to sporadic aplastic anemia and malignancy","volume":"162","author":"Gramatges","year":"2013","journal-title":"Translational Research"},{"issue":"8","key":"10.1016\/bs.acr.2018.12.003_bb0260","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1182\/blood-2004-05-1812","article-title":"Prevalence of anemia in persons 65 years and older in the United States: Evidence for a high rate of unexplained anemia","volume":"104","author":"Guralnik","year":"2004","journal-title":"Blood"},{"key":"10.1016\/bs.acr.2018.12.003_bb0265","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/leu.2013.336","article-title":"Landscape of genetic lesions in 944 patients with myelodysplastic syndromes","volume":"28","author":"Haferlach","year":"2013","journal-title":"Leukemia"},{"issue":"8","key":"10.1016\/bs.acr.2018.12.003_bb0270","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1182\/blood-2015-06-652941","article-title":"Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms","volume":"128","author":"Hinds","year":"2016","journal-title":"Blood"},{"key":"10.1016\/bs.acr.2018.12.003_bb0275","doi-asserted-by":"crossref","first-page":"12475","DOI":"10.1038\/ncomms12475","article-title":"Genetic hierarchy and temporal variegation in the clonal history of acute myeloid leukaemia","volume":"7","author":"Hirsch","year":"2016","journal-title":"Nature Communications"},{"issue":"14","key":"10.1016\/bs.acr.2018.12.003_bb0280","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1101\/gad.14.14.1810","article-title":"BCoR, a novel corepressor involved in BCL-6 repression","volume":"14","author":"Huynh","year":"2000","journal-title":"Genes & Development"},{"issue":"6","key":"10.1016\/bs.acr.2018.12.003_bb0285","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/ng.2270","article-title":"Detectable clonal mosaicism and its relationship to aging and cancer","volume":"44","author":"Jacobs","year":"2012","journal-title":"Nature Genetics"},{"issue":"26","key":"10.1016\/bs.acr.2018.12.003_bb0290","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1056\/NEJMoa1408617","article-title":"Age-related clonal hematopoiesis associated with adverse outcomes","volume":"371","author":"Jaiswal","year":"2014","journal-title":"The New England Journal of Medicine"},{"issue":"2","key":"10.1016\/bs.acr.2018.12.003_bb0295","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1701719","article-title":"Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease","volume":"337","author":"Jaiswal","year":"2017","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/bs.acr.2018.12.003_bb0300","doi-asserted-by":"crossref","first-page":"3502","DOI":"10.1038\/onc.2011.68","article-title":"Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control","volume":"30","author":"J\u00e4kel","year":"2011","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0305","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1053\/j.seminhematol.2016.10.002","article-title":"Clonal hematopoiesis","volume":"54","author":"Jan","year":"2017","journal-title":"Seminars in Hematology"},{"issue":"37","key":"10.1016\/bs.acr.2018.12.003_bb0310","doi-asserted-by":"crossref","first-page":"23128","DOI":"10.1016\/S0021-9258(17)31629-0","article-title":"Cytosolic NADP(+)-dependent isocitrate dehydrogenase. Isolation of rat cDNA and study of tissue-specific and developmental expression of mRNA","volume":"269","author":"Jennings","year":"1994","journal-title":"Journal of Biological Chemistry"},{"issue":"13","key":"10.1016\/bs.acr.2018.12.003_bb0315","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1056\/NEJMoa1716863","article-title":"Molecular minimal residual disease in acute myeloid leukemia","volume":"378","author":"Jongen-Lavrencic","year":"2018","journal-title":"The New England Journal of Medicine"},{"issue":"2","key":"10.1016\/bs.acr.2018.12.003_bb0320","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccell.2018.07.001","article-title":"Comprehensive analysis of alternative splicing across tumors from 8,705 patients","volume":"34","author":"Kahles","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/bs.acr.2018.12.003_bb0325","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1182\/blood-2018-05-850339","article-title":"PPM1D truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells","volume":"132","author":"Kahn","year":"2018","journal-title":"Blood"},{"key":"10.1016\/bs.acr.2018.12.003_bb0330","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1038\/nature02633","article-title":"Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting","volume":"429","author":"Kaneda","year":"2004","journal-title":"Nature"},{"issue":"2","key":"10.1016\/bs.acr.2018.12.003_bb0335","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1056\/NEJMe1706173","article-title":"CHIP-ping away at atherosclerosis","volume":"377","author":"Keaney","year":"2017","journal-title":"New England Journal of Medicine"},{"issue":"5013","key":"10.1016\/bs.acr.2018.12.003_bb0340","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1126\/science.2047879","article-title":"Identification of p53 as a sequence-specific DNA-binding protein","volume":"252","author":"Kern","year":"1991","journal-title":"Science"},{"key":"10.1016\/bs.acr.2018.12.003_bb0345","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ng.342","article-title":"A germline JAK2 SNP is associated with predisposition to the development of JAK2V617F-positive myeloproliferative neoplasms","volume":"41","author":"Kilpivaara","year":"2009","journal-title":"Nature Genetics"},{"issue":"7","key":"10.1016\/bs.acr.2018.12.003_bb0350","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1074\/jbc.M005784200","article-title":"The adapter type protein CMS\/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction","volume":"276","author":"Kirsch","year":"2001","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/bs.acr.2018.12.003_bb0355","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nature09586","article-title":"Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2","volume":"468","author":"Ko","year":"2010","journal-title":"Nature"},{"key":"10.1016\/bs.acr.2018.12.003_bb0360","doi-asserted-by":"crossref","first-page":"10.1.1","DOI":"10.1002\/cphg.36","article-title":"Overview of genetic diagnosis in cancer","volume":"93","author":"Korf","year":"2017","journal-title":"Current Protocols in Human Genetics"},{"issue":"7","key":"10.1016\/bs.acr.2018.12.003_bb0365","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1101\/gad.4.7.1158","article-title":"Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells","volume":"4","author":"Krainer","year":"1990","journal-title":"Genes & Development"},{"issue":"21","key":"10.1016\/bs.acr.2018.12.003_bb0370","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1182\/blood-2015-08-667063","article-title":"MDS-associated somatic mutations and clonal hematopoiesis are common in idiopathic cytopenias of undetermined significance","volume":"126","author":"Kwok","year":"2015","journal-title":"Blood"},{"key":"10.1016\/bs.acr.2018.12.003_bb0375","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/leu.2013.30","article-title":"Low frequency clonal mutations recoverable by deep sequencing in patients with aplastic anemia","volume":"27","author":"Lane","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/bs.acr.2018.12.003_bb0380","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ng.391","article-title":"Acquired mutations in TET2 are common in myelodysplastic syndromes","volume":"41","author":"Langemeijer","year":"2009","journal-title":"Nature Genetics"},{"issue":"6","key":"10.1016\/bs.acr.2018.12.003_bb0385","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/ng.2271","article-title":"Detectable clonal mosaicism from birth to old age and its relationship to cancer","volume":"44","author":"Laurie","year":"2012","journal-title":"Nature Genetics"},{"issue":"6676","key":"10.1016\/bs.acr.2018.12.003_bb0390","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/33345","article-title":"Essential role of mouse telomerase in highly proliferative organs","volume":"392","author":"Lee","year":"1998","journal-title":"Nature"},{"key":"10.1016\/bs.acr.2018.12.003_bb0395","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/s41586-018-0497-0","article-title":"Population dynamics of normal human blood inferred from somatic mutations","volume":"561","author":"Lee-Six","year":"2018","journal-title":"Nature"},{"issue":"2","key":"10.1016\/bs.acr.2018.12.003_bb0400","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.gendis.2018.04.001","article-title":"Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to atherlosclerotic cardio\/cerebro-vascular diseases?","volume":"5","author":"Li","year":"2018","journal-title":"Genes & Diseases"},{"key":"10.1016\/bs.acr.2018.12.003_bb0405","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1161\/CIRCULATIONAHA.118.034392","article-title":"CHIP (clonal hematopoiesis of indeterminate potential)","volume":"138","author":"Libby","year":"2018","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/bs.acr.2018.12.003_bb0410","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1182\/blood.V85.9.2528.bloodjournal8592528","article-title":"Lymphoma-associated translocation t(14;18) in blood B cells of normal individuals","volume":"85","author":"Limpens","year":"1995","journal-title":"Blood"},{"issue":"6","key":"10.1016\/bs.acr.2018.12.003_bb0415","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1056\/NEJMoa1611604","article-title":"Prognostic mutations in myelodysplastic syndrome after stem-cell transplantation","volume":"376","author":"Lindsley","year":"2017","journal-title":"The New England Journal of Medicine"},{"issue":"2","key":"10.1016\/bs.acr.2018.12.003_bb0420","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/ni1033","article-title":"Age-related changes in lymphocyte development and function","volume":"5","author":"Linton","year":"2004","journal-title":"Nature Immunology"},{"issue":"19","key":"10.1016\/bs.acr.2018.12.003_bb0425","doi-asserted-by":"crossref","first-page":"8910","DOI":"10.1073\/pnas.91.19.8910","article-title":"BCL2 translocation frequency rises with age in humans","volume":"91","author":"Liu","year":"1994","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7714","key":"10.1016\/bs.acr.2018.12.003_bb0430","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/s41586-018-0321-x","article-title":"Insights into clonal haematopoiesis from 8,342 mosaic chromosomal alterations","volume":"559","author":"Loh","year":"2018","journal-title":"Nature"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0435","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1042\/BJ20081501","article-title":"The SR protein family of splicing factors: Master regulators of gene expression","volume":"417","author":"Long","year":"2009","journal-title":"Biochemical Journal"},{"issue":"6","key":"10.1016\/bs.acr.2018.12.003_bb0440","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0092-8674(93)90719-7","article-title":"p53-dependent apoptosis modulates the cytotoxicity of anticancer agents","volume":"74","author":"Lowe","year":"1993","journal-title":"Cell"},{"issue":"2","key":"10.1016\/bs.acr.2018.12.003_bb0445","first-page":"135","article-title":"Sex chromatin and gene action in the mammalian X-chromosome","volume":"14","author":"Lyon","year":"1962","journal-title":"American Journal of Human Genetics"},{"issue":"7, Supplement","key":"10.1016\/bs.acr.2018.12.003_bb0450","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.amjmed.2012.04.014","article-title":"Epidemiology of myelodysplastic syndromes","volume":"125","author":"Ma","year":"2012","journal-title":"The American Journal of Medicine"},{"issue":"11","key":"10.1016\/bs.acr.2018.12.003_bb0455","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1056\/NEJMoa0903840","article-title":"Recurring mutations found by sequencing an acute myeloid leukemia genome","volume":"361","author":"Mardis","year":"2009","journal-title":"The New England Journal of Medicine"},{"issue":"13","key":"10.1016\/bs.acr.2018.12.003_bb0460","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1002\/j.1460-2075.1984.tb02287.x","article-title":"Isolation and characterization of a human p53 cDNA clone: Expression of the human p53 gene","volume":"3","author":"Matlashewski","year":"1984","journal-title":"The EMBO Journal"},{"issue":"4","key":"10.1016\/bs.acr.2018.12.003_bb0465","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1182\/blood-2014-08-594648","article-title":"Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation","volume":"125","author":"Mayle","year":"2015","journal-title":"Blood"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0470","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1073\/pnas.83.1.130","article-title":"The gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13)","volume":"83","author":"McBride","year":"1986","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"10.1016\/bs.acr.2018.12.003_bb0475","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.celrep.2015.02.005","article-title":"Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis","volume":"10","author":"McKerrell","year":"2015","journal-title":"Cell Reports"},{"issue":"5","key":"10.1016\/bs.acr.2018.12.003_bb0480","doi-asserted-by":"crossref","first-page":"461","DOI":"10.6004\/jnccn.2017.7058","article-title":"Misdiagnosis of Li-Fraumeni syndrome in a patient with clonal hematopoiesis and a somatic TP53 mutation","volume":"16","author":"Mitchell","year":"2018","journal-title":"Journal of the National Comprehensive Cancer Network"},{"issue":"5099","key":"10.1016\/bs.acr.2018.12.003_bb0485","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.7680492","article-title":"The cloning of PIG-A, a component in the early step of GPI-anchor biosynthesis","volume":"259","author":"Miyata","year":"1993","journal-title":"Science"},{"issue":"4","key":"10.1016\/bs.acr.2018.12.003_bb0490","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1056\/NEJM199401273300404","article-title":"Abnormalities of PIG-A transcripts in granulocytes from patients with paroxysmal nocturnal hemoglobinuria","volume":"330","author":"Miyata","year":"1994","journal-title":"New England Journal of Medicine"},{"issue":"12","key":"10.1016\/bs.acr.2018.12.003_bb0495","doi-asserted-by":"crossref","first-page":"8242","DOI":"10.1073\/pnas.112218799","article-title":"Chromosome translocations and covert leukemic clones are generated during normal fetal development","volume":"99","author":"Mori","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"10.1016\/bs.acr.2018.12.003_bb0500","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41591-018-0064-0","article-title":"Myeloid cell contributions to cardiovascular health and disease","volume":"24","author":"Nahrendorf","year":"2018","journal-title":"Nature Medicine"},{"issue":"7","key":"10.1016\/bs.acr.2018.12.003_bb0505","article-title":"Clonal hematopoiesis: Somatic mutations in blood cells and atherosclerosis","volume":"11","author":"Natarajan","year":"2018","journal-title":"Circulation: Genomic and Precision Medicine"},{"issue":"12","key":"10.1016\/bs.acr.2018.12.003_bb0510","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/oxfordjournals.molbev.a025894","article-title":"Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family","volume":"15","author":"Nekrutenko","year":"1998","journal-title":"Molecular Biology and Evolution"},{"issue":"5","key":"10.1016\/bs.acr.2018.12.003_bb0515","first-page":"1013","article-title":"Chromosome studies in human leukemia. II. Chronic granulocytic leukemia","volume":"27","author":"Nowell","year":"1961","journal-title":"JNCI: Journal of the National Cancer Institute"},{"key":"10.1016\/bs.acr.2018.12.003_bb0520","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/leu.2014.48","article-title":"The germline sequence variant rs2736100_C in TERT associates with myeloproliferative neoplasms","volume":"28","author":"Oddsson","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/bs.acr.2018.12.003_bb0525","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/890","article-title":"Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases","volume":"19","author":"Okano","year":"1998","journal-title":"Nature Genetics"},{"issue":"20","key":"10.1016\/bs.acr.2018.12.003_bb0530","doi-asserted-by":"crossref","first-page":"15248","DOI":"10.1074\/jbc.M700246200","article-title":"A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP","volume":"282","author":"Pagan","year":"2007","journal-title":"Journal of Biological Chemistry"},{"issue":"23","key":"10.1016\/bs.acr.2018.12.003_bb0535","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1056\/NEJMoa1516192","article-title":"Genomic classification and prognosis in acute myeloid leukemia","volume":"374","author":"Papaemmanuil","year":"2016","journal-title":"New England Journal of Medicine"},{"issue":"5","key":"10.1016\/bs.acr.2018.12.003_bb0540","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1182\/blood-2007-06-095703","article-title":"Host genetic variation contributes to phenotypic diversity in myeloproliferative disorders","volume":"111","author":"Pardanani","year":"2008","journal-title":"Blood"},{"key":"10.1016\/bs.acr.2018.12.003_bb0545","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/416187a","article-title":"The endophilin\u2013CIN85\u2013Cbl complex mediates ligand-dependent downregulation of c-Met","volume":"416","author":"Petrelli","year":"2002","journal-title":"Nature"},{"issue":"1\u20132","key":"10.1016\/bs.acr.2018.12.003_bb0550","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.cell.2012.01.003","article-title":"Aging, rejuvenation, and epigenetic reprogramming: Resetting the aging clock","volume":"148","author":"Rando","year":"2012","journal-title":"Cell"},{"issue":"7","key":"10.1016\/bs.acr.2018.12.003_bb0555","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1101\/gad.276568.115","article-title":"Role of TET enzymes in DNA methylation, development, and cancer","volume":"30","author":"Rasmussen","year":"2016","journal-title":"Genes & Development"},{"issue":"37","key":"10.1016\/bs.acr.2018.12.003_bb0560","doi-asserted-by":"crossref","first-page":"21765","DOI":"10.1074\/jbc.270.37.21765","article-title":"Isolation of cDNA clones encoding eight different human G protein \u03b3 subunits, including three novel forms designated the \u03b34, \u03b310, and \u03b311 subunits","volume":"270","author":"Ray","year":"1995","journal-title":"Journal of Biological Chemistry"},{"issue":"6859","key":"10.1016\/bs.acr.2018.12.003_bb0565","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/35102167","article-title":"Stem cells, cancer, and cancer stem cells","volume":"414","author":"Reya","year":"2001","journal-title":"Nature"},{"issue":"7145","key":"10.1016\/bs.acr.2018.12.003_bb0570","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature05862","article-title":"Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age","volume":"447","author":"Rossi","year":"2007","journal-title":"Nature"},{"issue":"26","key":"10.1016\/bs.acr.2018.12.003_bb0575","doi-asserted-by":"crossref","first-page":"9194","DOI":"10.1073\/pnas.0503280102","article-title":"Cell intrinsic alterations underlie hematopoietic stem cell aging","volume":"102","author":"Rossi","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.acr.2018.12.003_bb0580","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/243290a0","article-title":"A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and giemsa staining","volume":"243","author":"Rowley","year":"1973","journal-title":"Nature"},{"issue":"2","key":"10.1016\/bs.acr.2018.12.003_bb0585","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0092-8674(88)90509-0","article-title":"A factor, U2AF, is required for U2 snRNP binding and splicing complex assembly","volume":"52","author":"Ruskin","year":"1988","journal-title":"Cell"},{"issue":"29","key":"10.1016\/bs.acr.2018.12.003_bb0590","doi-asserted-by":"crossref","first-page":"17528","DOI":"10.1074\/jbc.270.29.17528","article-title":"The Jak kinases differentially associate with the alpha and beta (accessory factor) chains of the interferon gamma receptor to form a functional receptor unit capable of activating STAT transcription factors","volume":"270","author":"Sakatsume","year":"1995","journal-title":"The Journal of Biological Chemistry"},{"issue":"3","key":"10.1016\/bs.acr.2018.12.003_bb0595","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1006\/bbrc.1998.8685","article-title":"Cloning and characterization of human Jak-2 kinase: High mRNA expression in immune cells and muscle tissue","volume":"246","author":"Saltzman","year":"1998","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"8","key":"10.1016\/bs.acr.2018.12.003_bb0600","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/j.jacc.2017.12.037","article-title":"Tet2-mediated clonal hematopoiesis accelerates heart failure through a mechanism involving the IL-1\u03b2\/NLRP3 inflammasome","volume":"71","author":"Sano","year":"2018","journal-title":"Journal of the American College of Cardiology"},{"issue":"8","key":"10.1016\/bs.acr.2018.12.003_bb0605","doi-asserted-by":"crossref","DOI":"10.1038\/s41408-018-0107-2","article-title":"Clonal hematopoiesis in patients with rheumatoid arthritis","volume":"8","author":"Savola","year":"2018","journal-title":"Blood Cancer Journal"},{"key":"10.1016\/bs.acr.2018.12.003_bb0610","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/nrm1762","article-title":"The Cbl interactome and its functions","volume":"6","author":"Schmidt","year":"2005","journal-title":"Nature Reviews Molecular Cell Biology"},{"issue":"5","key":"10.1016\/bs.acr.2018.12.003_bb0615","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1182\/blood-2017-07-746453","article-title":"Age-related clonal hematopoiesis","volume":"131","author":"Shlush","year":"2018","journal-title":"Blood"},{"issue":"7488","key":"10.1016\/bs.acr.2018.12.003_bb0620","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature13038","article-title":"Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia","volume":"506","author":"Shlush","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0625","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1182\/blood-2002-11-3343","article-title":"Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: The University of Chicago series","volume":"102","author":"Smith","year":"2003","journal-title":"Blood"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0630","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/nrc.2016.112","article-title":"The genetics of myelodysplastic syndrome: From clonal haematopoiesis to secondary leukaemia","volume":"17","author":"Sperling","year":"2017","journal-title":"Nature Reviews. Cancer"},{"issue":"8","key":"10.1016\/bs.acr.2018.12.003_bb0635","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1016\/j.mayocp.2018.04.002","article-title":"Clinical implications of clonal hematopoiesis","volume":"93","author":"Steensma","year":"2018","journal-title":"Mayo Clinic Proceedings"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0640","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2015-03-631747","article-title":"Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes","volume":"126","author":"Steensma","year":"2015","journal-title":"Blood"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0645","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13059-018-1492-3","article-title":"Homeobox oncogene activation by pan-cancer DNA hypermethylation","volume":"19","author":"Su","year":"2018","journal-title":"Genome Biology"},{"issue":"9","key":"10.1016\/bs.acr.2018.12.003_bb0650","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1084\/jem.192.9.1273","article-title":"Age-associated characteristics of murine hematopoietic stem cells","volume":"192","author":"Sudo","year":"2000","journal-title":"The Journal of Experimental Medicine"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0655","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S1470-2045(16)30626-X","article-title":"Preleukaemic clonal haemopoiesis and risk of therapy-related myeloid neoplasms: A case-control study","volume":"18","author":"Takahashi","year":"2017","journal-title":"The Lancet Oncology"},{"issue":"4","key":"10.1016\/bs.acr.2018.12.003_bb0660","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/0092-8674(93)90250-T","article-title":"Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria","volume":"73","author":"Takeda","year":"1993","journal-title":"Cell"},{"issue":"51","key":"10.1016\/bs.acr.2018.12.003_bb0665","doi-asserted-by":"crossref","first-page":"35805","DOI":"10.1074\/jbc.M805468200","article-title":"Nuclear inhibitor of protein phosphatase-1 (NIPP1) directs protein phosphatase-1 (PP1) to dephosphorylate the U2 small nuclear ribonucleoprotein particle (snRNP) component, spliceosome-associated protein 155 (Sap155)","volume":"283","author":"Tanuma","year":"2008","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/bs.acr.2018.12.003_bb0670","doi-asserted-by":"crossref","first-page":"6691","DOI":"10.1038\/ncomms7691","article-title":"Genetic variation at MECOM, TERT, JAK2 and HBS1L-MYB predisposes to myeloproliferative neoplasms","volume":"6","author":"Tapper","year":"2015","journal-title":"Nature Communications"},{"issue":"10","key":"10.1016\/bs.acr.2018.12.003_bb0675","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMc1806413","article-title":"High-risk clonal hematopoiesis as the origin of AITL and NPM1-mutated AML","volume":"379","author":"Tiacci","year":"2018","journal-title":"New England Journal of Medicine"},{"issue":"18","key":"10.1016\/bs.acr.2018.12.003_bb0680","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1182\/blood-2014-05-526285","article-title":"Bone marrow failure and the telomeropathies","volume":"124","author":"Townsley","year":"2014","journal-title":"Blood"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0685","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/ajh.24946","article-title":"MECOM, HBS1L-MYB, THRB-RARB, JAK2, and TERT polymorphisms defining the genetic predisposition to myeloproliferative neoplasms: A study on 939 patients","volume":"93","author":"Trifa","year":"2018","journal-title":"American Journal of Hematology"},{"issue":"2","key":"10.1016\/bs.acr.2018.12.003_bb0690","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/bjh.14041","article-title":"TERT rs2736100 A>C SNP and JAK2 46\/1 haplotype significantly contribute to the occurrence of JAK2 V617F and CALR mutated myeloproliferative neoplasms\u2014A multicentric study on 529 patients","volume":"174","author":"Trifa","year":"2016","journal-title":"British Journal of Haematology"},{"issue":"5","key":"10.1016\/bs.acr.2018.12.003_bb0695","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1182\/blood-2009-03-209262","article-title":"The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: Rationale and important changes","volume":"114","author":"Vardiman","year":"2009","journal-title":"Blood"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0700","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13059-018-1467-4","article-title":"Splicing heterogeneity: Separating signal from noise","volume":"19","author":"Wan","year":"2018","journal-title":"Genome Biology"},{"key":"10.1016\/bs.acr.2018.12.003_bb0705","doi-asserted-by":"crossref","first-page":"e35","DOI":"10.1161\/CIRCRESAHA.118.313283","article-title":"Macrophage inflammation, erythrophagocytosis and accelerated atherosclerosis in Jak2V617F mice","volume":"123","author":"Wang","year":"2018","journal-title":"Circulation Research"},{"issue":"22","key":"10.1016\/bs.acr.2018.12.003_bb0710","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1182\/blood-2014-04-568055","article-title":"Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres","volume":"124","author":"Wang","year":"2014","journal-title":"Blood"},{"issue":"5","key":"10.1016\/bs.acr.2018.12.003_bb0715","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.cell.2012.01.040","article-title":"A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage","volume":"148","author":"Wang","year":"2012","journal-title":"Cell"},{"issue":"2","key":"10.1016\/bs.acr.2018.12.003_bb0720","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2012.06.023","article-title":"The origin and evolution of mutations in acute myeloid leukemia","volume":"150","author":"Welch","year":"2012","journal-title":"Cell"},{"issue":"436","key":"10.1016\/bs.acr.2018.12.003_bb0725","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan8292","article-title":"Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms","volume":"10","author":"Wolach","year":"2018","journal-title":"Science Translational Medicine"},{"issue":"6","key":"10.1016\/bs.acr.2018.12.003_bb0730","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0168-9525(92)90232-S","article-title":"Telomere positional effects and the regulation of cellular senescence","volume":"8","author":"Wright","year":"1992","journal-title":"Trends in Genetics"},{"key":"10.1016\/bs.acr.2018.12.003_bb0735","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/45590","article-title":"Functional recognition of the 3\u2032 splice site AG by the splicing factor U2AF35","volume":"402","author":"Wu","year":"1999","journal-title":"Nature"},{"issue":"12","key":"10.1016\/bs.acr.2018.12.003_bb0740","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1038\/nm.3733","article-title":"Age-related mutations associated with clonal hematopoietic expansion and malignancies","volume":"20","author":"Xie","year":"2014","journal-title":"Nature Medicine"},{"issue":"4","key":"10.1016\/bs.acr.2018.12.003_bb0745","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.stem.2018.03.013","article-title":"Large-scale clonal analysis resolves aging of the mouse hematopoietic stem cell compartment","volume":"22","author":"Yamamoto","year":"2018","journal-title":"Cell Stem Cell"},{"issue":"12","key":"10.1016\/bs.acr.2018.12.003_bb0750","doi-asserted-by":"crossref","first-page":"7141","DOI":"10.1074\/jbc.271.12.7141","article-title":"Differential ability to form the G protein \u03b2\u03b3 complex among members of the \u03b2 and \u03b3 subunit families","volume":"271","author":"Yan","year":"1996","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/bs.acr.2018.12.003_bb0755","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nrc3895","article-title":"DNMT3A in haematological malignancies","volume":"15","author":"Yang","year":"2015","journal-title":"Nature Reviews Cancer"},{"issue":"1","key":"10.1016\/bs.acr.2018.12.003_bb0760","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1056\/NEJMoa1414799","article-title":"Somatic mutations and clonal hematopoiesis in aplastic anemia","volume":"373","author":"Yoshizato","year":"2015","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/bs.acr.2018.12.003_bb0765","doi-asserted-by":"crossref","first-page":"12484","DOI":"10.1038\/ncomms12484","article-title":"Clonal haematopoiesis harbouring AML-associated mutations is ubiquitous in healthy adults","volume":"7","author":"Young","year":"2016","journal-title":"Nature Communications"},{"issue":"11","key":"10.1016\/bs.acr.2018.12.003_bb0770","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1182\/blood-2017-08-802033","article-title":"The impact of aging on primate hematopoiesis as interrogated by clonal tracking","volume":"131","author":"Yu","year":"2018","journal-title":"Blood"},{"issue":"7692","key":"10.1016\/bs.acr.2018.12.003_bb0775","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature25477","article-title":"Structural basis for DNMT3A-mediated de novo DNA methylation","volume":"554","author":"Zhang","year":"2018","journal-title":"Nature"},{"issue":"6","key":"10.1016\/bs.acr.2018.12.003_bb0780","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1182\/blood-2017-02-769869","article-title":"Clonal hematopoiesis, with and without candidate driver mutations, is common in the elderly","volume":"130","author":"Zink","year":"2017","journal-title":"Blood"}],"container-title":["Advances in Cancer Research","Cancer Stem Cells"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065230X1830071X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065230X1830071X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T19:11:59Z","timestamp":1758741119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065230X1830071X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9780128149942"],"references-count":155,"URL":"https:\/\/doi.org\/10.1016\/bs.acr.2018.12.003","relation":{},"ISSN":["0065-230X"],"issn-type":[{"value":"0065-230X","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}