{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:30:57Z","timestamp":1793089857716,"version":"4.5.0"},"reference-count":123,"publisher":"Elsevier","isbn-type":[{"value":"9780128241257","type":"print"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/bs.acr.2021.05.002","type":"book-chapter","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T08:25:59Z","timestamp":1627892759000},"page":"67-102","source":"Crossref","is-referenced-by-count":140,"title":["Head and neck cancer: Current challenges and future perspectives"],"prefix":"10.1016","member":"78","reference":[{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0010","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/annonc\/mds503","article-title":"A phase II trial of dacomitinib, an oral pan-human EGF receptor (HER) inhibitor, as first-line treatment in recurrent and\/or metastatic squamous-cell carcinoma of the head and neck","volume":"24","author":"Abdul Razak","year":"2013","journal-title":"Annals of Oncology"},{"issue":"8","key":"10.1016\/bs.acr.2021.05.002_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-019-1769-9","article-title":"Clinical update on head and neck cancer: Molecular biology and ongoing challenges","volume":"10","author":"Alsahafi","year":"2019","journal-title":"Cell Death & Disease"},{"issue":"12","key":"10.1016\/bs.acr.2021.05.002_bb0020","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1096\/fj.06-6191com","article-title":"Receptor-mediated tobacco toxicity: Cooperation of the Ras\/Raf-1\/MEK1\/ERK and JAK-2\/STAT-3 pathways downstream of a7 nicotinic receptor in oral keratinocytes","volume":"20","author":"Arredondo","year":"2006","journal-title":"The FASEB Journal"},{"issue":"8","key":"10.1016\/bs.acr.2021.05.002_bb0025","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1172\/JCI91190","article-title":"IFN-\u03b3\u2013related mRNA profile predicts clinical response to PD-1 blockade","volume":"127","author":"Ayers","year":"2017","journal-title":"The Journal of Clinical Investigation"},{"issue":"13","key":"10.1016\/bs.acr.2021.05.002_bb0030","first-page":"5262","article-title":"Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density","volume":"61","author":"Beasley","year":"2001","journal-title":"Cancer Research"},{"issue":"10","key":"10.1016\/bs.acr.2021.05.002_bb0035","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/hed.20279","article-title":"Defining risk levels in locally advanced head and neck cancers: A comparative analysis of concurrent postoperative radiation plus chemotherapy trials of the EORTC (# 22931) and RTOG (# 9501)","volume":"27","author":"Bernier","year":"2005","journal-title":"Head & Neck"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0040","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S1470-2045(09)70311-0","article-title":"Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a phase 3 randomised trial, and relation between cetuximab-induced rash and survival","volume":"11","author":"Bonner","year":"2010","journal-title":"The Lancet Oncology"},{"issue":"11","key":"10.1016\/bs.acr.2021.05.002_bb0045","first-page":"3408","article-title":"Smad4 loss in mice causes spontaneous head and neck cancer with increased genomic instability and inflammation","volume":"119","author":"Bornstein","year":"2009","journal-title":"The Journal of Clinical Investigation"},{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0050","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM199301213280302","article-title":"Influence of cigarette smoking on the efficacy of radiation therapy in head and neck cancer","volume":"328","author":"Browman","year":"1993","journal-title":"New England Journal of Medicine"},{"issue":"9","key":"10.1016\/bs.acr.2021.05.002_bb0055","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1177\/0022034517712435","article-title":"STAT3 induces immunosuppression by upregulating PD-1\/PD-L1 in HNSCC","volume":"96","author":"Bu","year":"2017","journal-title":"Journal of Dental Research"},{"issue":"5","key":"10.1016\/bs.acr.2021.05.002_bb0060","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.stem.2017.02.003","article-title":"Targeting BMI1+ cancer stem cells overcomes chemoresistance and inhibits metastases in squamous cell carcinoma","volume":"20","author":"Chen","year":"2017","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0065","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1158\/1078-0432.CCR-17-0866","article-title":"CD271 confers an invasive and metastatic phenotype of head and neck squamous cell carcinoma through the upregulation of slug","volume":"24","author":"Chung","year":"2018","journal-title":"Clinical Cancer Research"},{"issue":"25","key":"10.1016\/bs.acr.2021.05.002_bb0070","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1200\/JCO.2013.54.6309","article-title":"Phase III randomized trial of induction chemotherapy in patients with N2 or N3 locally advanced head and neck cancer","volume":"32","author":"Cohen","year":"2014","journal-title":"Journal of Clinical Oncology"},{"issue":"50","key":"10.1016\/bs.acr.2021.05.002_bb0075","doi-asserted-by":"crossref","first-page":"13254","DOI":"10.1073\/pnas.1711777114","article-title":"\u0394Np63-mediated regulation of hyaluronic acid metabolism and signaling supports HNSCC tumorigenesis","volume":"114","author":"Compagnone","year":"2017","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"19","key":"10.1016\/bs.acr.2021.05.002_bb0080","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"New England Journal of Medicine"},{"issue":"58","key":"10.1016\/bs.acr.2021.05.002_bb0085","doi-asserted-by":"crossref","first-page":"97928","DOI":"10.18632\/oncotarget.17880","article-title":"Targeting PLK1 as a novel chemopreventive approach to eradicate preneoplastic mucosal changes in the head and neck","volume":"8","author":"de Boer","year":"2017","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/bs.acr.2021.05.002_bb0090","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2017.1356148","article-title":"The prognostic role of tumor infiltrating T-lymphocytes in squamous cell carcinoma of the head and neck: A systematic review and meta-analysis","volume":"6","author":"de Ruiter","year":"2017","journal-title":"Oncoimmunology"},{"issue":"3\u20134","key":"10.1016\/bs.acr.2021.05.002_bb0095","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10555-012-9375-7","article-title":"TGF-\u03b2 signalling and its role in cancer progression and metastasis","volume":"31","author":"Drabsch","year":"2012","journal-title":"Cancer and Metastasis Reviews"},{"issue":"10","key":"10.1016\/bs.acr.2021.05.002_bb0100","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1093\/annonc\/mdx346","article-title":"A phase II study of temsirolimus added to low-dose weekly carboplatin and paclitaxel for patients with recurrent and\/or metastatic (R\/M) head and neck squamous cell carcinoma (HNSCC)","volume":"28","author":"Dunn","year":"2017","journal-title":"Annals of Oncology"},{"issue":"2","key":"10.1016\/bs.acr.2021.05.002_bb0105","first-page":"321","article-title":"CD44 as a stem cell marker in head and neck squamous cell carcinoma","volume":"26","author":"Faber","year":"2011","journal-title":"Oncology Reports"},{"issue":"29","key":"10.1016\/bs.acr.2021.05.002_bb0110","doi-asserted-by":"crossref","first-page":"3293","DOI":"10.1200\/JCO.2015.61.1509","article-title":"Immunology and immunotherapy of head and neck cancer","volume":"33","author":"Ferris","year":"2015","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/bs.acr.2021.05.002_bb0115","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1056\/NEJMoa1602252","article-title":"Nivolumab for recurrent squamous-cell carcinoma of the head and neck","volume":"375","author":"Ferris","year":"2016","journal-title":"The New England Journal of Medicine"},{"issue":"11","key":"10.1016\/bs.acr.2021.05.002_bb0120","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1158\/1940-6207.CAPR-14-0179","article-title":"New DNA methylation markers and global DNA hypomethylation are associated with oral cancer development","volume":"8","author":"Foy","year":"2015","journal-title":"Cancer Prevention Research"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0125","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1200\/JCO.2017.76.2591","article-title":"Induction chemotherapy followed by cetuximab radiotherapy is not superior to concurrent chemoradiotherapy for head and neck carcinomas: Results of the GORTEC 2007-02 phase III randomized trial","volume":"36","author":"Geoffrois","year":"2018","journal-title":"Journal of Clinical Oncology"},{"issue":"7","key":"10.1016\/bs.acr.2021.05.002_bb0130","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1172\/JCI3785","article-title":"Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro","volume":"102","author":"Grandis","year":"1998","journal-title":"The Journal of Clinical Investigation"},{"issue":"8","key":"10.1016\/bs.acr.2021.05.002_bb0135","doi-asserted-by":"crossref","first-page":"4227","DOI":"10.1073\/pnas.97.8.4227","article-title":"Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo","volume":"97","author":"Grandis","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0140","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/0360-3016(92)90845-9","article-title":"Influence of carboxyhemoglobin level on tumor growth, blood flow, and radiation response in an experimental model","volume":"22","author":"Grau","year":"1992","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"9","key":"10.1016\/bs.acr.2021.05.002_bb0145","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1172\/JCI80008","article-title":"Tumor neoantigens: Building a framework for personalized cancer immunotherapy","volume":"125","author":"Gubin","year":"2015","journal-title":"The Journal of Clinical Investigation"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0150","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S1470-2045(05)70540-4","article-title":"Promoter methylation and inactivation of tumour-suppressor genes in oral squamous-cell carcinoma","volume":"7","author":"Ha","year":"2006","journal-title":"The Lancet Oncology"},{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0155","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/sj.onc.1210644","article-title":"Ajuba negatively regulates the Wnt signaling pathway by promoting GSK-3 \u03b2-mediated phosphorylation of \u03b2-catenin","volume":"27","author":"Haraguchi","year":"2008","journal-title":"Oncogene"},{"issue":"29","key":"10.1016\/bs.acr.2021.05.002_bb0160","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1200\/JCO.2015.62.1086","article-title":"Genetic landscape of human papillomavirus\u2013associated head and neck cancer and comparison to tobacco-related tumors","volume":"33","author":"Hayes","year":"2015","journal-title":"Journal of Clinical Oncology"},{"issue":"8","key":"10.1016\/bs.acr.2021.05.002_bb0165","first-page":"2722","article-title":"Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression","volume":"118","author":"Hoot","year":"2008","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.acr.2021.05.002_bb0170","first-page":"3475","article-title":"Polo-like kinase 2 acting as a promoter in human tumor cells with an abundance of TAp73","volume":"8","author":"Hu","year":"2015","journal-title":"Oncotargets and Therapy"},{"issue":"2","key":"10.1016\/bs.acr.2021.05.002_bb0175","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.stem.2020.06.022","article-title":"BMI1 inhibition eliminates residual cancer stem cells after PD1 blockade and activates antitumor immunity to prevent metastasis and relapse","volume":"27","author":"Jia","year":"2020","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nature Reviews. Disease Primers"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0185","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrclinonc.2014.192","article-title":"Emerging biomarkers in head and neck cancer in the era of genomics","volume":"12","author":"Kang","year":"2015","journal-title":"Nature Reviews. Clinical Oncology"},{"issue":"5","key":"10.1016\/bs.acr.2021.05.002_bb0190","first-page":"7497","article-title":"Application of molecular targeted therapies in the treatment of head and neck squamous cell carcinoma","volume":"15","author":"Kozakiewicz","year":"2018","journal-title":"Oncology Letters"},{"issue":"10","key":"10.1016\/bs.acr.2021.05.002_bb0195","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1038\/bjc.1998.260","article-title":"Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: Role of the transmembrane pH gradient","volume":"77","author":"Kozin","year":"1998","journal-title":"British Journal of Cancer"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0200","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nm.3418","article-title":"Self-renewal as a therapeutic target in human colorectal cancer","volume":"20","author":"Kreso","year":"2014","journal-title":"Nature Medicine"},{"key":"10.1016\/bs.acr.2021.05.002_bb0205","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nature14129","article-title":"Comprehensive genomic characterization of head and neck squamous cell carcinomas","volume":"517","author":"Lawrence","year":"2015","journal-title":"Nature"},{"issue":"5","key":"10.1016\/bs.acr.2021.05.002_bb0210","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/labinvest.2015.163","article-title":"Notch1 signaling contributes to stemness in head and neck squamous cell carcinoma","volume":"96","author":"Lee","year":"2016","journal-title":"Laboratory Investigation"},{"key":"10.1016\/bs.acr.2021.05.002_bb0215","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.oraloncology.2018.08.001","article-title":"Patterns of failure in high-metastatic node number human papillomavirus-positive oropharyngeal carcinoma","volume":"85","author":"Lee","year":"2018","journal-title":"Oral Oncology"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0220","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc2982","article-title":"The molecular biology of head and neck cancer","volume":"11","author":"Leemans","year":"2011","journal-title":"Nature Reviews Cancer"},{"issue":"5","key":"10.1016\/bs.acr.2021.05.002_bb0225","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrc.2018.11","article-title":"The molecular landscape of head and neck cancer","volume":"18","author":"Leemans","year":"2018","journal-title":"Nature Reviews Cancer"},{"key":"10.1016\/bs.acr.2021.05.002_bb0230","doi-asserted-by":"crossref","DOI":"10.5402\/2012\/708974","article-title":"Hypoxia in head and neck squamous cell carcinoma","volume":"2012","author":"Li","year":"2012","journal-title":"ISRN Otolaryngology"},{"key":"10.1016\/bs.acr.2021.05.002_bb0235","series-title":"Paper presented at the Seminars in Radiation Oncology","article-title":"Role of immunotherapy in head and neck cancer","author":"Ling","year":"2018"},{"issue":"9","key":"10.1016\/bs.acr.2021.05.002_bb0240","doi-asserted-by":"crossref","first-page":"6887","DOI":"10.18632\/oncotarget.3159","article-title":"G9a is essential for EMT-mediated metastasis and maintenance of cancer stem cell-like characters in head and neck squamous cell carcinoma","volume":"6","author":"Liu","year":"2015","journal-title":"Oncotarget"},{"issue":"10","key":"10.1016\/bs.acr.2021.05.002_bb0245","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1101\/gad.1413306","article-title":"Loss of transforming growth factor-\u03b2 type II receptor promotes metastatic head-and-neck squamous cell carcinoma","volume":"20","author":"Lu","year":"2006","journal-title":"Genes & Development"},{"issue":"10","key":"10.1016\/bs.acr.2021.05.002_bb0250","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.neo.2014.08.014","article-title":"CK2 phosphorylates and inhibits TAp73 tumor suppressor function to promote expression of cancer stem cell genes and phenotype in head and neck cancer","volume":"16","author":"Lu","year":"2014","journal-title":"Neoplasia"},{"issue":"7","key":"10.1016\/bs.acr.2021.05.002_bb0255","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1158\/2159-8290.CD-13-0103","article-title":"Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers","volume":"3","author":"Lui","year":"2013","journal-title":"Cancer Discovery"},{"issue":"7","key":"10.1016\/bs.acr.2021.05.002_bb0260","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/j.1460-2075.1995.tb07127.x","article-title":"An amino acid substitution in the Drosophila hopTum-l Jak kinase causes leukemia-like hematopoietic defects","volume":"14","author":"Luo","year":"1995","journal-title":"The EMBO Journal"},{"issue":"4","key":"10.1016\/bs.acr.2021.05.002_bb0265","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1007\/s12094-016-1551-8","article-title":"Effect of adaptive replanning in patients with locally advanced nasopharyngeal carcinoma treated by intensity-modulated radiotherapy: A propensity score matched analysis","volume":"19","author":"Luo","year":"2017","journal-title":"Clinical and Translational Oncology"},{"issue":"4","key":"10.1016\/bs.acr.2021.05.002_bb0270","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S1470-2045(11)70034-1","article-title":"Zalutumumab plus best supportive care versus best supportive care alone in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck after failure of platinum-based chemotherapy: An open-label, randomised phase 3 trial","volume":"12","author":"Machiels","year":"2011","journal-title":"The Lancet Oncology"},{"issue":"7","key":"10.1016\/bs.acr.2021.05.002_bb0275","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.ctrv.2010.03.008","article-title":"DNA mismatch repair and the DNA damage response to ionizing radiation: Making sense of apparently conflicting data","volume":"36","author":"Martin","year":"2010","journal-title":"Cancer Treatment Reviews"},{"key":"10.1016\/bs.acr.2021.05.002_bb0280","doi-asserted-by":"crossref","first-page":"6067","DOI":"10.1200\/jco.2013.31.15_suppl.6067","article-title":"Phase II trial of everolimus and erlotinib in patients with platinum-resistant recurrent and\/or metastatic head and neck squamous cell carcinoma","volume":"31","author":"Massarelli","year":"2013","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/bs.acr.2021.05.002_bb0285","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1146\/annurev-med-051914-021907","article-title":"HPV-associated head and neck cancer: Unique features of epidemiology and clinical management","volume":"67","author":"Maxwell","year":"2016","journal-title":"Annual Review of Medicine"},{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0290","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1002\/ijc.24010","article-title":"Guidelines for human papillomavirus DNA test requirements for primary cervical cancer screening in women 30 years and older","volume":"124","author":"Meijer","year":"2009","journal-title":"International Journal of Cancer"},{"issue":"2","key":"10.1016\/bs.acr.2021.05.002_bb0295","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/path.2785","article-title":"The dynamic roles of TGF-\u03b2 in cancer","volume":"223","author":"Meulmeester","year":"2011","journal-title":"The Journal of Pathology"},{"key":"10.1016\/bs.acr.2021.05.002_bb0300","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.ctro.2017.10.005","article-title":"Treatment de-escalation for HPV-driven oropharyngeal cancer: Where do we stand?","volume":"8","author":"Mirghani","year":"2018","journal-title":"Clinical and Translational Radiation Oncology"},{"issue":"5","key":"10.1016\/bs.acr.2021.05.002_bb0305","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.ijrobp.2017.03.024","article-title":"Clinical advances of hypoxia-activated prodrugs in combination with radiation therapy","volume":"98","author":"Mistry","year":"2017","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"6","key":"10.1016\/bs.acr.2021.05.002_bb0310","first-page":"2183","article-title":"CAR T cell therapy: A new era for cancer treatment","volume":"42","author":"Mohanty","year":"2019","journal-title":"Oncology Reports"},{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0315","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/ng.2538","article-title":"Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation","volume":"45","author":"Morris","year":"2013","journal-title":"Nature Genetics"},{"issue":"2","key":"10.1016\/bs.acr.2021.05.002_bb0320","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11912-018-0654-5","article-title":"Immunotherapy for head and neck squamous cell carcinoma","volume":"20","author":"Moskovitz","year":"2018","journal-title":"Current Oncology Reports"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0325","first-page":"101","article-title":"Oncogenic mutations of the PIK3CA gene in head and neck squamous cell carcinomas","volume":"32","author":"Murugan","year":"2008","journal-title":"International Journal of Oncology"},{"issue":"9","key":"10.1016\/bs.acr.2021.05.002_bb0330","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1002\/cncr.10499","article-title":"Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis","volume":"94","author":"Nagpal","year":"2002","journal-title":"Cancer"},{"issue":"34","key":"10.1016\/bs.acr.2021.05.002_bb0335","doi-asserted-by":"crossref","first-page":"3858","DOI":"10.1200\/JCO.2014.55.3925","article-title":"Randomized phase III trial to test accelerated versus standard fractionation in combination with concurrent cisplatin for head and neck carcinomas in the Radiation Therapy Oncology Group 0129 trial: Long-term report of efficacy and toxicity","volume":"32","author":"Nguyen-Tan","year":"2014","journal-title":"Journal of Clinical Oncology"},{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0340","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.radonc.2007.04.021","article-title":"Differential risk assessments from five hypoxia specific assays: The basis for biologically adapted individualized radiotherapy in advanced head and neck cancer patients","volume":"83","author":"Nordsmark","year":"2007","journal-title":"Radiotherapy and Oncology"},{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0345","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrc.2016.145","article-title":"Notch as a tumour suppressor","volume":"17","author":"Nowell","year":"2017","journal-title":"Nature Reviews Cancer"},{"issue":"2","key":"10.1016\/bs.acr.2021.05.002_bb0350","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1470-2045(10)70290-4","article-title":"Parotid-sparing intensity modulated versus conventional radiotherapy in head and neck cancer (PARSPORT): A phase 3 multicentre randomised controlled trial","volume":"12","author":"Nutting","year":"2011","journal-title":"The Lancet Oncology"},{"issue":"24","key":"10.1016\/bs.acr.2021.05.002_bb0355","doi-asserted-by":"crossref","first-page":"6308","DOI":"10.1158\/1078-0432.CCR-17-3535","article-title":"Loss of function of canonical notch signaling drives head and neck carcinogenesis","volume":"24","author":"Nyman","year":"2018","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/bs.acr.2021.05.002_bb0360","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.oraloncology.2018.01.024","article-title":"CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma","volume":"78","author":"Park","year":"2018","journal-title":"Oral Oncology"},{"issue":"7635","key":"10.1016\/bs.acr.2021.05.002_bb0365","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nature20791","article-title":"Targeting metastasis-initiating cells through the fatty acid receptor CD36","volume":"541","author":"Pascual","year":"2017","journal-title":"Nature"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0370","first-page":"1","article-title":"The hypoxic tumour microenvironment","volume":"7","author":"Petrova","year":"2018","journal-title":"Oncogene"},{"issue":"7","key":"10.1016\/bs.acr.2021.05.002_bb0375","doi-asserted-by":"crossref","first-page":"873","DOI":"10.6004\/jnccn.2020.0031","article-title":"Head and neck cancers, version 2.2020, NCCN clinical practice guidelines in oncology","volume":"18","author":"Pfister","year":"2020","journal-title":"Journal of the National Comprehensive Cancer Network"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0380","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.radonc.2009.04.014","article-title":"Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): An update on 93 randomised trials and 17,346 patients","volume":"92","author":"Pignon","year":"2009","journal-title":"Radiotherapy and Oncology"},{"issue":"17","key":"10.1016\/bs.acr.2021.05.002_bb0385","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1056\/NEJMoa070956","article-title":"Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer","volume":"357","author":"Posner","year":"2007","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0390","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.stem.2018.12.009","article-title":"Cancer stem cells: The architects of the tumor ecosystem","volume":"24","author":"Prager","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0395","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1073\/pnas.0610117104","article-title":"Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma","volume":"104","author":"Prince","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"21","key":"10.1016\/bs.acr.2021.05.002_bb0400","doi-asserted-by":"crossref","first-page":"5701","DOI":"10.1182\/blood-2010-04-280123","article-title":"Stat3 signaling in acute myeloid leukemia: Ligand-dependent and-independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor","volume":"117","author":"Redell","year":"2011","journal-title":"Blood"},{"key":"10.1016\/bs.acr.2021.05.002_bb0405","first-page":"1927","article-title":"Molecularly targeted therapy for the treatment of head and neck cancer: A review of the ErbB family inhibitors","volume":"9","author":"Sacco","year":"2016","journal-title":"Oncotargets and Therapy"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0410","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.stem.2018.11.017","article-title":"Targeting cancer stemness in the clinic: From hype to hope","volume":"24","author":"Saygin","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"11","key":"10.1016\/bs.acr.2021.05.002_bb0415","doi-asserted-by":"crossref","first-page":"R445","DOI":"10.1016\/j.cub.2015.02.034","article-title":"Ajuba proteins","volume":"25","author":"Schimizzi","year":"2015","journal-title":"Current Biology"},{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0420","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.ijrobp.2011.08.017","article-title":"Adaptive radiotherapy for head-and-neck cancer: Initial clinical outcomes from a prospective trial","volume":"83","author":"Schwartz","year":"2012","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"8","key":"10.1016\/bs.acr.2021.05.002_bb0425","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1158\/2159-8290.CD-12-0191","article-title":"First-in-human trial of a STAT3 decoy oligonucleotide in head and neck tumors: Implications for cancer therapy","volume":"2","author":"Sen","year":"2012","journal-title":"Cancer Discovery"},{"issue":"8","key":"10.1016\/bs.acr.2021.05.002_bb0430","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0043898","article-title":"Nicotine promotes proliferation of human nasopharyngeal carcinoma cells by regulating \u03b17AChR, ERK, HIF-1\u03b1 and VEGF\/PEDF signaling","volume":"7","author":"Shi","year":"2012","journal-title":"PLoS One"},{"issue":"7\u20138","key":"10.1016\/bs.acr.2021.05.002_bb0435","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/0360-3016(78)90189-X","article-title":"Smoking: The influence of carboxyhemoglobin (HbCO) on tumor oxygenation and response to radiation","volume":"4","author":"Siemann","year":"1978","journal-title":"International Journal of Radiation Oncology, Biology, Physics"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0440","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/1878-0261.12155","article-title":"Emerging functions of the EGFR in cancer","volume":"12","author":"Sigismund","year":"2018","journal-title":"Molecular Oncology"},{"issue":"4","key":"10.1016\/bs.acr.2021.05.002_bb0445","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bbrc.2008.04.128","article-title":"TGF-\u03b21 induced MMP-9 expression in HNSCC cell lines via Smad\/MLCK pathway","volume":"371","author":"Sinpitaksakul","year":"2008","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"4","key":"10.1016\/bs.acr.2021.05.002_bb0450","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.oraloncology.2012.10.009","article-title":"Epithelial to mesenchymal transition in head and neck squamous cell carcinoma","volume":"49","author":"Smith","year":"2013","journal-title":"Oral Oncology"},{"issue":"26","key":"10.1016\/bs.acr.2021.05.002_bb0455","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1038\/sj.onc.1208601","article-title":"Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma","volume":"24","author":"Snijders","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/bs.acr.2021.05.002_bb0460","series-title":"Paper presented at the Seminars in cancer biology","article-title":"Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments","author":"Solomon","year":"2018"},{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0465","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1158\/1078-0432.CCR-13-1050","article-title":"Common and complex Notch1 mutations in Chinese oral squamous cell carcinoma","volume":"20","author":"Song","year":"2014","journal-title":"Clinical Cancer Research"},{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0470","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S1470-2045(17)30064-5","article-title":"Buparlisib and paclitaxel in patients with platinum-pretreated recurrent or metastatic squamous cell carcinoma of the head and neck (BERIL-1): A randomised, double-blind, placebo-controlled phase 2 trial","volume":"18","author":"Souli\u00e8res","year":"2017","journal-title":"The Lancet Oncology"},{"issue":"9","key":"10.1016\/bs.acr.2021.05.002_bb0475","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1080\/14656566.2016.1183647","article-title":"Afatinib in squamous cell carcinoma of the head and neck","volume":"17","author":"Specenier","year":"2016","journal-title":"Expert Opinion on Pharmacotherapy"},{"issue":"16","key":"10.1016\/bs.acr.2021.05.002_bb0480","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1158\/1078-0432.CCR-17-3775","article-title":"\u0394Np63\u03b3\/SRC\/slug signaling axis promotes epithelial-to-mesenchymal transition in squamous cancers","volume":"24","author":"Srivastava","year":"2018","journal-title":"Clinical Cancer Research"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0485","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1158\/1541-7786.MCR-07-0208","article-title":"Transforming growth factor-\u03b21 promotes matrix metalloproteinase-9\u2013mediated oral cancer invasion through snail expression","volume":"6","author":"Sun","year":"2008","journal-title":"Molecular Cancer Research"},{"issue":"4","key":"10.1016\/bs.acr.2021.05.002_bb0490","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1158\/0008-5472.CAN-13-1259","article-title":"Activation of the NOTCH pathway in head and neck cancer","volume":"74","author":"Sun","year":"2014","journal-title":"Cancer Research"},{"issue":"10","key":"10.1016\/bs.acr.2021.05.002_bb0495","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1002\/ijc.25927","article-title":"Head neck squamous cell carcinoma c-Met+ cells display cancer stem cell properties and are responsible for cisplatin-resistance and metastasis","volume":"129","author":"Sun","year":"2011","journal-title":"International Journal of Cancer"},{"key":"10.1016\/bs.acr.2021.05.002_bb0500","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jcv.2004.11.017","article-title":"Human papillomavirus (HPV) in head and neck cancer","volume":"32","author":"Syrj\u00e4nen","year":"2005","journal-title":"Journal of Clinical Virology"},{"issue":"14","key":"10.1016\/bs.acr.2021.05.002_bb0505","doi-asserted-by":"crossref","first-page":"5851","DOI":"10.1158\/0008-5472.CAN-08-4518","article-title":"Nimotuzumab, an antitumor antibody that targets the epidermal growth factor receptor, blocks ligand binding while permitting the active receptor conformation","volume":"69","author":"Talavera","year":"2009","journal-title":"Cancer Research"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0510","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1182\/asheducation-2006.1.240","article-title":"Classification, diagnosis and management of myeloproliferative disorders in the JAK2 V617F Era","volume":"2006","author":"Tefferi","year":"2006","journal-title":"American Society of Hematology Education Program book"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0515","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jcv.2014.06.019","article-title":"Variable expression of the forgotten oncogene E5 in HPV-positive oropharyngeal cancer","volume":"61","author":"Um","year":"2014","journal-title":"Journal of Clinical Virology"},{"issue":"3","key":"10.1016\/bs.acr.2021.05.002_bb0520","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00280-008-0911-7","article-title":"The comparison of weekly and three-weekly cisplatin chemotherapy concurrent with radiotherapy in patients with previously untreated inoperable non-metastatic squamous cell carcinoma of the head and neck","volume":"64","author":"Uygun","year":"2009","journal-title":"Cancer Chemotherapy and Pharmacology"},{"key":"10.1016\/bs.acr.2021.05.002_bb0525","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.3389\/fimmu.2018.02134","article-title":"CD38 antibodies in multiple myeloma: Mechanisms of action and modes of resistance","volume":"9","author":"Van De Donk","year":"2018","journal-title":"Frontiers in Immunology"},{"issue":"23","key":"10.1016\/bs.acr.2021.05.002_bb0530","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1007\/s00018-008-8281-1","article-title":"The cell-cell adhesion molecule E-cadherin","volume":"65","author":"Van Roy","year":"2008","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"7","key":"10.1016\/bs.acr.2021.05.002_bb0535","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1111\/odi.12206","article-title":"The PI 3 K\/A kt\/m TOR axis in head and neck cancer: Functions, aberrations, cross-talk, and therapies","volume":"21","author":"Vander Broek","year":"2015","journal-title":"Oral Diseases"},{"issue":"17","key":"10.1016\/bs.acr.2021.05.002_bb0540","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1056\/NEJMoa071028","article-title":"Cisplatin, fluorouracil, and docetaxel in unresectable head and neck cancer","volume":"357","author":"Vermorken","year":"2007","journal-title":"New England Journal of Medicine"},{"issue":"8","key":"10.1016\/bs.acr.2021.05.002_bb0545","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S1470-2045(13)70181-5","article-title":"Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): An open-label phase 3 randomised trial","volume":"14","author":"Vermorken","year":"2013","journal-title":"The Lancet Oncology"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0550","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/ijc.11028","article-title":"Promoter hypermethylation profile of tumor-associated genes p16, p15, hMLH1, MGMT and E-cadherin in oral squamous cell carcinoma","volume":"105","author":"Viswanathan","year":"2003","journal-title":"International Journal of Cancer"},{"issue":"10","key":"10.1016\/bs.acr.2021.05.002_bb0555","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1089\/ars.2013.5378","article-title":"The clinical importance of assessing tumor hypoxia: Relationship of tumor hypoxia to prognosis and therapeutic opportunities","volume":"21","author":"Walsh","year":"2014","journal-title":"Antioxidants & Redox Signaling"},{"issue":"4","key":"10.1016\/bs.acr.2021.05.002_bb0560","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1158\/1535-7163.MCT-16-0606","article-title":"Suppression of the growth and invasion of human head and neck squamous cell carcinomas via regulating STAT3 signaling and the miR-21\/\u03b2-catenin axis with HJC0152","volume":"16","author":"Wang","year":"2017","journal-title":"Molecular Cancer Therapeutics"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0565","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/hed.20935","article-title":"In vivo investigation of CD133 as a putative marker of cancer stem cells in Hep-2 cell line","volume":"31","author":"Wei","year":"2009","journal-title":"Head & Neck"},{"issue":"7528","key":"10.1016\/bs.acr.2021.05.002_bb0570","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nature14001","article-title":"Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing","volume":"515","author":"Yadav","year":"2014","journal-title":"Nature"},{"issue":"11","key":"10.1016\/bs.acr.2021.05.002_bb0575","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.3390\/ijms18112420","article-title":"Molecular-targeted therapies for epidermal growth factor receptor and its resistance mechanisms","volume":"18","author":"Yamaoka","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"issue":"5","key":"10.1016\/bs.acr.2021.05.002_bb0580","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.3892\/mmr.2016.5054","article-title":"Expression profile analysis of head and neck squamous cell carcinomas using data from The Cancer Genome Atlas","volume":"13","author":"Yan","year":"2016","journal-title":"Molecular Medicine Reports"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0585","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/mt.2012.184","article-title":"Cetuximab-mediated tumor regression depends on innate and adaptive immune responses","volume":"21","author":"Yang","year":"2013","journal-title":"Molecular Therapy"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0590","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/jcp.28963","article-title":"The molecular markers of cancer stem cells in head and neck tumors","volume":"235","author":"Yu","year":"2020","journal-title":"Journal of Cellular Physiology"},{"issue":"11","key":"10.1016\/bs.acr.2021.05.002_bb0595","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/nrc3818","article-title":"Revisiting STAT3 signalling in cancer: New and unexpected biological functions","volume":"14","author":"Yu","year":"2014","journal-title":"Nature Reviews Cancer"},{"key":"10.1016\/bs.acr.2021.05.002_bb0600","doi-asserted-by":"crossref","first-page":"24927","DOI":"10.1038\/srep24927","article-title":"Integrative genomics and transcriptomics analysis reveals potential mechanisms for favorable prognosis of patients with HPV-positive head and neck carcinomas","volume":"6","author":"Zhang","year":"2016","journal-title":"Scientific Reports"},{"issue":"5","key":"10.1016\/bs.acr.2021.05.002_bb0605","doi-asserted-by":"crossref","first-page":"881","DOI":"10.17219\/acem\/64000","article-title":"The notch signaling pathway in head and neck squamous cell carcinoma: A meta-analysis","volume":"26","author":"Zhao","year":"2017","journal-title":"Advances in Clinical and Experimental Medicine"},{"issue":"1","key":"10.1016\/bs.acr.2021.05.002_bb0610","first-page":"1","article-title":"NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell","volume":"6","author":"Zhao","year":"2016","journal-title":"Scientific Reports"},{"issue":"2","key":"10.1016\/bs.acr.2021.05.002_bb0615","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1530-0277.2012.01936.x","article-title":"Long-term binge and escalating ethanol exposure causes necroinflammation and fibrosis in rat liver","volume":"37","author":"Zhou","year":"2013","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"5","key":"10.1016\/bs.acr.2021.05.002_bb0620","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1038\/nrc798","article-title":"Papillomaviruses and cancer: From basic studies to clinical application","volume":"2","author":"Zur Hausen","year":"2002","journal-title":"Nature Reviews Cancer"}],"container-title":["Advances in Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065230X21000452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065230X21000452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T13:37:03Z","timestamp":1753796223000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065230X21000452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9780128241257"],"references-count":123,"URL":"https:\/\/doi.org\/10.1016\/bs.acr.2021.05.002","relation":{},"ISSN":["0065-230X"],"issn-type":[{"value":"0065-230X","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]}}}