{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T09:03:17Z","timestamp":1789549397461,"version":"build-2803163510"},"reference-count":170,"publisher":"Elsevier","isbn-type":[{"value":"9780443432385","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2R15HL145573-02"],"award-info":[{"award-number":["2R15HL145573-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R15AI151970-01"],"award-info":[{"award-number":["1R15AI151970-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R15CA161491-01A1"],"award-info":[{"award-number":["1R15CA161491-01A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005768","name":"West Virginia Space Grant Consortium","doi-asserted-by":"publisher","award":["80NSSC20M0055"],"award-info":[{"award-number":["80NSSC20M0055"]}],"id":[{"id":"10.13039\/100005768","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.acr.2026.07.001","type":"book-chapter","created":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T20:23:19Z","timestamp":1784838199000},"page":"1-74","source":"Crossref","is-referenced-by-count":0,"title":["Memantine and its analogs: Potential applications in cancer therapy"],"prefix":"10.1016","author":[{"given":"Kaitlyn B.","family":"Conley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen C.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javan C.","family":"Christian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kushal J.","family":"Modi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher R.","family":"Bender","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"McGuffey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Akter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Miles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd W.","family":"Gress","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca S.","family":"Wolfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Antoniano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory H.","family":"Cummings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista L.","family":"Denning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica A.","family":"Valentovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piyali","family":"Dasgupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.acr.2026.07.001_bib0001","first-page":"12","article-title":"The epigenetic mechanisms involved in the treatment resistance of glioblastoma","volume":"8","author":"Aanya","year":"2025","journal-title":"Cancer Drug Resistance"},{"key":"10.1016\/bs.acr.2026.07.001_bib0002","doi-asserted-by":"crossref","first-page":"757","DOI":"10.37349\/etat.2023.00166","volume":"4","author":"Abdallah","year":"2023","journal-title":"Medicinal chemistry advances in targeting class I histone deacetylases Exploration of Targeted Anti-tumor Therapy"},{"key":"10.1016\/bs.acr.2026.07.001_bib0003","first-page":"106","article-title":"The use of neuron specific enolase in the prognosis and followup of neuroblastoma in children. Results of a retrospective series of 21 patients","volume":"78","author":"Abdennebi","year":"2000","journal-title":"La Tunisie M\u00e9dicale"},{"key":"10.1016\/bs.acr.2026.07.001_bib0004","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s00232-005-0777-0","article-title":"N-methyl-D-aspartate receptor in human prostate cancer","volume":"205","author":"Abdul","year":"2005","journal-title":"Journal of Membrane Biology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0005","doi-asserted-by":"crossref","first-page":"841","DOI":"10.55730\/1300-0144.5381","article-title":"Does memantine show chemopreventive effect against mice 4T1 breast tumor model?","volume":"52","author":"Albayrak","year":"2022","journal-title":"Turkish Journal of Medical Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0006","first-page":"223","article-title":"Memantine shifts cancer cell metabolism via AMPK1\/2 mediated energetic switch in A549 lung cancer cells","volume":"20","author":"Albayrak","year":"2021","journal-title":"EXCLI Journal"},{"key":"10.1016\/bs.acr.2026.07.001_bib0007","first-page":"20","article-title":"Antitumorigenic Effect of Memantine via Interfering Glutamate Metabolism in Mouse 4T1 Breast Tumor Model","author":"Albayrak","year":"2020","journal-title":"Anti-Cancer Agents in Medicinal Chemistry"},{"key":"10.1016\/bs.acr.2026.07.001_bib0008","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1177\/0960327117747025","article-title":"Memantine induces apoptosis and inhibits cell cycle progression in LNCaP prostate cancer cells","volume":"37","author":"Albayrak","year":"2018","journal-title":"Human & Experimental Toxicology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0009","first-page":"499","article-title":"Alzheimer's drug Memantine inhibits metastasis and p-Erk protein expression on 4T1 breast cancer cells","volume":"121","author":"Albayrak","year":"2020","journal-title":"Bratislavske Lekarske Listy"},{"key":"10.1016\/bs.acr.2026.07.001_bib0010","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1124\/mol.106.029702","article-title":"Reversal of Stathmin-Mediated Resistance to Paclitaxel and Vinblastine in Human Breast Carcinoma Cells","volume":"71","author":"Alli","year":"2007","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0011","first-page":"11","article-title":"Drug Repurposing for Glioblastoma and Current Advances in Drug Delivery-A Comprehensive Review of Literature","author":"Alomari","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/bs.acr.2026.07.001_bib0012","first-page":"13","article-title":"Advances in Glioblastoma Therapy: An Update on Current Approaches","author":"Angom","year":"2023","journal-title":"Brain Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0013","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1053\/j.gastro.2020.02.068","article-title":"Global Burden of 5 Major Types of Gastrointestinal Cancer","volume":"159","author":"Arnold","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0014","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S0889-8588(05)70269-0","article-title":"Diagnosis and Management of Brain Metastases","volume":"15","author":"Arnold","year":"2001","journal-title":"Hematology\/Oncology Clinics"},{"key":"10.1016\/bs.acr.2026.07.001_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.130231","article-title":"Exploration of newly synthesized amantadine-thiourea conjugates for their DNA binding, anti-elastase, and anti-glioma potentials","volume":"263","author":"Arshad","year":"2024","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/bs.acr.2026.07.001_bib0016","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1007\/s13311-021-01142-2","article-title":"Chemotherapy-Induced Peripheral Neuropathy: Mechanisms and Therapeutic Avenues","volume":"18","author":"Bae","year":"2021","journal-title":"Neurotherapeutics"},{"key":"10.1016\/bs.acr.2026.07.001_bib0017","doi-asserted-by":"crossref","first-page":"775","DOI":"10.17776\/csj.768907","article-title":"Memantine inhibits cell proliferation and activates LKB1-AMPK pathway in breast carcinoma","volume":"41","author":"Bali","year":"2020","journal-title":"Cumhuriyet Science Journal"},{"key":"10.1016\/bs.acr.2026.07.001_bib0018","doi-asserted-by":"crossref","first-page":"11182","DOI":"10.3748\/wjg.v20.i32.11182","article-title":"Pancreatic ductal adenocarcinoma: risk factors, screening, and early detection. Methotrexate an Old Drug with New Tricks","volume":"20","author":"Becker","year":"2014","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0019","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1177\/1078155219901305","article-title":"Toxicity, risk factors and management of cisplatin-induced toxicity: A prospective study","volume":"26","author":"Ben Ayed","year":"2020","journal-title":"Journal of Oncology Pharmacy Practice"},{"key":"10.1016\/bs.acr.2026.07.001_bib0020","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-1-4939-3999-2_14","article-title":"The Rip1Tag2 Transgenic Mouse Model","volume":"1464","author":"Bill","year":"2016","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0021","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1442888","article-title":"Tumor microenvironment and cancer metastasis: molecular mechanisms and therapeutic implications","volume":"15","author":"Biray Avci","year":"2024","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117473","article-title":"Therapeutic prospects of sex hormone receptor signaling in hormone-responsive cancers","volume":"180","author":"Boye","year":"2024","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/bs.acr.2026.07.001_bib0023","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/BF03161096","article-title":"Case files of the program in medical toxicology at brown university: amantadine withdrawal and the neuroleptic malignant syndrome","volume":"5","author":"Brantley","year":"2009","journal-title":"Journal of Medical Toxicology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0024","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1200\/JCO.2017.75.9589","article-title":"Whole-Brain Radiotherapy for Brain Metastases: Evolution or Revolution?","volume":"36","author":"Brown","year":"2018","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0025","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1200\/JCO.19.02767","article-title":"Hippocampal Avoidance During Whole-Brain Radiotherapy Plus Memantine for Patients with Brain Metastases: Phase III Trial NRG Oncology CC001","volume":"38","author":"Brown","year":"2020","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0026","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1093\/neuonc\/not114","article-title":"Memantine for the prevention of cognitive dysfunction in patients receiving whole-brain radiotherapy: a randomized, double-blind, placebo-controlled trial","volume":"15","author":"Brown","year":"2013","journal-title":"Neuro-Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0027","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ejps.2017.08.030","article-title":"Memantine-derived drugs as potential antitumor agents for the treatment of glioblastoma","volume":"109","author":"Cacciatore","year":"2017","journal-title":"European Journal of Pharmaceutical Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103689","article-title":"The crosstalk between glutathione metabolism and non-coding RNAs in cancer progression and treatment resistance","volume":"84","author":"Chang","year":"2025","journal-title":"Redox Biology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0029","doi-asserted-by":"crossref","DOI":"10.1016\/j.seminoncol.2025.152342","article-title":"The interest of therapeutic and pharmacological drug monitoring of methotrexate: A systematic review","volume":"52","author":"Chellal","year":"2025","journal-title":"Seminars in Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0030","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1002\/cac2.12345","article-title":"Tumor-associated macrophages in liver cancer: From mechanisms to therapy","volume":"42","author":"Cheng","year":"2022","journal-title":"Cancer Communications (London, England)"},{"key":"10.1016\/bs.acr.2026.07.001_bib0031","first-page":"2","article-title":"Raman Spectroscopy Could Facilitate Deployment of Amantadine-Based Cancer Screening Technology\u2014 Enabling the Transition from Labs to Villages","volume":"18","author":"Chimenti","year":"2015","journal-title":"American Pharmaceutical Review"},{"key":"10.1016\/bs.acr.2026.07.001_bib0032","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Preclinical versus clinical drug combination studies","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Research"},{"key":"10.1016\/bs.acr.2026.07.001_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2025.152456","article-title":"Chemotherapy-induced cognitive impairment: Mechanisms, emerging biomarkers, and therapeutic interventions","volume":"779","author":"Chughtai","year":"2025","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/bs.acr.2026.07.001_bib0034","first-page":"809","article-title":"The Antihyperalgic Effect of Memenatine in Rat Model Of Paclitaxel-induced Neuropathic Pain","volume":"64","author":"Ciotu","year":"2016","journal-title":"FARMACIA"},{"key":"10.1016\/bs.acr.2026.07.001_bib0035","doi-asserted-by":"crossref","first-page":"4446","DOI":"10.1158\/1078-0432.CCR-13-1179","article-title":"Memantine protects rats treated with intrathecal methotrexate from developing spatial memory deficits","volume":"19","author":"Cole","year":"2013","journal-title":"Clinical Cancer Research"},{"issue":"Suppl 1","key":"10.1016\/bs.acr.2026.07.001_bib0036","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/j.pain.0000000000001540","article-title":"Chemotherapy-induced peripheral neuropathy: where are we now?","volume":"160","author":"Colvin","year":"2019","journal-title":"Pain"},{"key":"10.1016\/bs.acr.2026.07.001_bib37","doi-asserted-by":"crossref","first-page":"838","DOI":"10.2174\/1570159X18666200221113842","article-title":"An Overview on Chemotherapy-induced Cognitive Impairment and Potential Role of Antidepressants","volume":"18","author":"Das","year":"2020","journal-title":"Current Neuropharmacology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0039","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.3390\/jcm15031101","article-title":"Neuroblastoma in Childhood: Biological Insights, Risk Stratification, and Advances in Multimodal Therapy","volume":"15","author":"De Bona","year":"2026","journal-title":"Journal of Clinical Medicine"},{"key":"10.1016\/bs.acr.2026.07.001_bib0040","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.3390\/ijms25052563","article-title":"Intrinsic and Microenvironmental Drivers of Glioblastoma Invasion","volume":"25","author":"De Fazio","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0041","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1002\/glia.21113","article-title":"Glutamate and the biology of gliomas","volume":"59","author":"de Groot","year":"2011","journal-title":"Glia,"},{"key":"10.1016\/bs.acr.2026.07.001_bib0042","first-page":"2586","article-title":"Endometrioid ovarian carcinoma landscape: pathological and molecular characterization","volume":"18","author":"de Nonneville","year":"2024","journal-title":"Molecular Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0043","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: From cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/bs.acr.2026.07.001_bib0037","first-page":"333","article-title":"Evidence That GRIN2A Mutations in Melanoma Correlate with Decreased Survival","volume":"3","author":"D'mello","year":"2014","journal-title":"Frontiers in Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0044","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s13046-015-0199-5","article-title":"Therapeutic potential of antiviral drugs targeting chemorefractory colorectal adenocarcinoma cells overexpressing endogenous retroviral elements","volume":"34","author":"D\u00edaz-Carballo","year":"2015","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"key":"10.1016\/bs.acr.2026.07.001_bib0045","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.3390\/ani14131941","article-title":"Evaluation of the Therapeutic Potential of Amantadine in a Vincristine-Induced Peripheral Neuropathy Model in Rats","volume":"14","author":"Drummond","year":"2024","journal-title":"Animals (Basel)"},{"key":"10.1016\/bs.acr.2026.07.001_bib0046","doi-asserted-by":"crossref","first-page":"6749","DOI":"10.3389\/fonc.2021.673340","article-title":"Doxorubicin-Induced Cognitive Impairment: The Mechanistic Insights","volume":"11","author":"Du","year":"2021","journal-title":"Frontiers in Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0047","doi-asserted-by":"crossref","first-page":"6749","DOI":"10.1007\/s11033-020-05733-8","article-title":"Roles of N-methyl-D-aspartate receptors and D-amino acids in cancer cell viability","volume":"47","author":"Du","year":"2020","journal-title":"Molecular Biology Reports"},{"key":"10.1016\/bs.acr.2026.07.001_bib0048","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.yexmp.2019.02.004","article-title":"Ketamine inhibits colorectal cancer cells malignant potential via blockage of NMDA receptor","volume":"107","author":"Duan","year":"2019","journal-title":"Experimental and Molecular Pathology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0049","doi-asserted-by":"crossref","first-page":"639","DOI":"10.3390\/ph17050639","article-title":"NMDA Receptor Antagonists: Emerging Insights into Molecular Mechanisms and Clinical Applications in Neurological Disorders","volume":"17","author":"Egunlusi","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/bs.acr.2026.07.001_bib0050","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0304-3959(97)00198-X","article-title":"Can patients with chronic neuropathic pain be cured by acute administration of the NMDA receptor antagonist amantadine?","volume":"74","author":"Eisenberg","year":"1998","journal-title":"Pain"},{"key":"10.1016\/bs.acr.2026.07.001_bib0051","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jpain.2006.08.003","article-title":"Effect of Early Administration of the N-Methyl-D-Aspartate Receptor Antagonist Amantadine on the Development of Postmastectomy Pain Syndrome: A Prospective Pilot Study","volume":"8","author":"Eisenberg","year":"2007","journal-title":"The Journal of Pain: Official Journal of the American Pain Society"},{"key":"10.1016\/bs.acr.2026.07.001_bib0052","doi-asserted-by":"crossref","first-page":"143","DOI":"10.5114\/fn.2021.107607","article-title":"Memantine improves memory and hippocampal proliferation in adult male rats","volume":"59","author":"Elbeltagy","year":"2021","journal-title":"Folia Neuropathologica"},{"key":"10.1016\/bs.acr.2026.07.001_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2024.106939","article-title":"Advances in understanding cisplatin-induced toxicity: Molecular mechanisms and protective strategies","volume":"203","author":"Elmorsy","year":"2024","journal-title":"European Journal of Pharmaceutical Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0054","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.720020","article-title":"Comprehensive Analysis of HDAC Family Identifies HDAC1 as a Prognostic and Immune Infiltration Indicator and HDAC1-Related Signature for Prognosis in Glioma","volume":"8","author":"Fan","year":"2021","journal-title":"Frontiers in Molecular Biosciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0055","doi-asserted-by":"crossref","first-page":"20440","DOI":"10.18632\/oncotarget.7812","article-title":"Glutamate dependent NMDA receptor 2D is a novel angiogenic tumour endothelial marker in colorectal cancer","volume":"7","author":"Ferguson","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/bs.acr.2026.07.001_bib0056","doi-asserted-by":"crossref","first-page":"P580","DOI":"10.1016\/j.jalz.2012.05.1578","article-title":"P3-353: Unexpected side effects of memantine newly introduced to Japanese patients with Alzheimer's disease: Complying with renal function cutoffs may be the key to safer use","volume":"8","author":"Fukui","year":"2012","journal-title":"Alzheimer's & Dementia"},{"key":"10.1016\/bs.acr.2026.07.001_bib0057","first-page":"25","author":"Gallego-Jara","year":"2020","journal-title":"A Compressive Review about Taxol(\u00ae): History and Future Challenges. Molecules"},{"key":"10.1016\/bs.acr.2026.07.001_bib0058","first-page":"24","article-title":"NMDA Receptor and Its Emerging Role in Cancer","author":"Gallo","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0059","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1016\/j.ijrobp.2023.08.028","article-title":"Primary Endpoint Results of NRG CC003: Phase IIR\/III Trial of Prophylactic Cranial Irradiation (PCI) with or without Hippocampal Avoidance (HA) for Small Cell Lung Cancer (SCLC)","volume":"117","author":"Gondi","year":"2023","journal-title":"International Journal of Radiation Oncology*Biology*Physics,"},{"key":"10.1016\/bs.acr.2026.07.001_bib0060","first-page":"1","article-title":"Anti-CV2\/CRMP5 Paraneoplastic Chorea Effectively Managed with Intravenous Amantadine","volume":"9","author":"Ha","year":"2019","journal-title":"Tremor and Other Hyperkinetic Movements (N Y)"},{"key":"10.1016\/bs.acr.2026.07.001_bib0061","first-page":"e29518","article-title":"Overview of Methotrexate Toxicity: A Comprehensive Literature Review","volume":"14","author":"Hamed","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/bs.acr.2026.07.001_bib0062","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41531-022-00291-1","article-title":"Amantadine delayed release\/extended-release capsules significantly reduce OFF time in Parkinson's disease","volume":"8","author":"Hauser","year":"2022","journal-title":"NPJ Parkinson's Disease"},{"key":"10.1016\/bs.acr.2026.07.001_bib0063","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1128\/AAC.23.3.458","article-title":"Differences in side effects of amantadine hydrochloride and rimantadine hydrochloride relate to differences in pharmacokinetics","volume":"23","author":"Hayden","year":"1983","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/bs.acr.2026.07.001_bib0064","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41572-024-00551-9","article-title":"Non-small-cell lung cancer","volume":"10","author":"Hendriks","year":"2024","journal-title":"Nature Reviews Disease Primers"},{"key":"10.1016\/bs.acr.2026.07.001_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejca.2024.114024","article-title":"Paclitaxel therapeutic drug monitoring - International association of therapeutic drug monitoring and clinical toxicology recommendations","volume":"202","author":"Hertz","year":"2024","journal-title":"European Journal of Cancer"},{"key":"10.1016\/bs.acr.2026.07.001_bib0066","doi-asserted-by":"crossref","first-page":"4995","DOI":"10.1038\/s41467-020-18819-5","article-title":"Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome","volume":"11","author":"Hollis","year":"2020","journal-title":"Nature Communications"},{"key":"10.1016\/bs.acr.2026.07.001_bib0067","first-page":"161","article-title":"Cancer-related fatigue: epidemiology, pathogenesis, diagnosis, and treatment","volume":"109","author":"Horneber","year":"2012","journal-title":"Deutsches \u00c4rzteblatt International"},{"key":"10.1016\/bs.acr.2026.07.001_bib0068","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12017-025-08902-9","article-title":"Neuronal Subtype-Specific Expression of \u03b3-Enolase: Its Role in Neuronal Differentiation","volume":"28","author":"Horvat","year":"2026","journal-title":"NeuroMolecular Medicine"},{"key":"10.1016\/bs.acr.2026.07.001_bib0069","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/1440-1681.13248","article-title":"Ketamine inhibits aerobic glycolysis in colorectal cancer cells by blocking the NMDA receptor-CaMK II-c-Myc pathway","volume":"47","author":"Hu","year":"2020","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0070","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.3390\/jcm14103367","article-title":"Laryngeal Cancer in the Modern Era: Evolving Trends in Diagnosis, Treatment, and Survival Outcomes","volume":"14","author":"Hut","year":"2025","journal-title":"Journal of Clinical Medicine"},{"key":"10.1016\/bs.acr.2026.07.001_bib0071","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fonc.2017.00193","article-title":"Lung Cancer: Understanding Its Molecular Pathology and the 2015 WHO Classification","volume":"7","author":"Inamura","year":"2017","journal-title":"Frontiers in Oncology"},{"issue":"2","key":"10.1016\/bs.acr.2026.07.001_bib0072","doi-asserted-by":"crossref","first-page":"345","DOI":"10.29228\/jrp.132","article-title":"Anti-tumor effect of memantine, an N-methyl-D-aspartate receptor antagonist, against DMH-induced colon cancer in rats","volume":"26","author":"Jannesar","year":"2022","journal-title":"Journal of Research in Pharmacy"},{"key":"10.1016\/bs.acr.2026.07.001_bib0073","doi-asserted-by":"crossref","unstructured":"Jannesar, K., Roosta, Y., Masoudi, N., Asghari, R., Rasouli, J., and Soraya, H. (2024). Anti-cancer effect of memantine as adjunctive therapy in metastatic colon cancer: A pilot randomized controlled clinical trial. medRxiv preprint doihttps:\/\/doi.org\/10.1101\/2024.09.01.24312896.","DOI":"10.22541\/au.172544053.37517221\/v1"},{"key":"10.1016\/bs.acr.2026.07.001_bib0074","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.neuint.2007.10.003","article-title":"The attenuating effect of memantine on staurosporine, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells","volume":"52","author":"Jantas","year":"2008","journal-title":"Neurochemistry International"},{"key":"10.1016\/bs.acr.2026.07.001_bib0075","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s12672-024-01010-3","article-title":"Targeting neutrophil elastase is a promising direction for future cancer treatment","volume":"15","author":"Jia","year":"2024","journal-title":"Discover Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0076","doi-asserted-by":"crossref","first-page":"8423","DOI":"10.3390\/ijms25158423","article-title":"Glutathione-Dependent Pathways in Cancer Cells","volume":"25","author":"Kalinina","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0077","doi-asserted-by":"crossref","first-page":"382","DOI":"10.5021\/ad.2009.21.4.382","article-title":"The Expression of NMDA Receptor 1 Correlates with Clinicopathological Parameters in Cutaneous Squamous Cell Carcinoma","volume":"21","author":"Kang","year":"2009","journal-title":"Annals of Dermatology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0078","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2022.115090","article-title":"Gliomas: Genetic alterations, mechanisms of metastasis, recurrence, drug resistance, and recent trends in molecular therapeutic options","volume":"201","author":"Kannan","year":"2022","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0079","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109737","article-title":"Memantine: Updating a rare success story in pro-cognitive therapeutics","volume":"244","author":"Karimi Tari","year":"2024","journal-title":"Neuropharmacology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0080","first-page":"119","article-title":"Apoptotic and antiproliferative effects of amantadine and rimantadine in glioblastoma cells","volume":"43","author":"Kasemsuk","year":"2019","journal-title":"Thai Journal of Pharmaceutical Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0081","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1176\/appi.neuropsych.20220206","article-title":"Adjunctive Memantine for Catatonia Due to Anti-NMDA Receptor Encephalitis","volume":"36","author":"Kim","year":"2024","journal-title":"The Journal of Neuropsychiatry and Clinical Neurosciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0082","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1001\/jama.2025.0560","article-title":"Small Cell Lung Cancer: A Review","volume":"333","author":"Kim","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/bs.acr.2026.07.001_bib0083","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1123841","article-title":"The role of glutamate receptors in the regulation of the tumor microenvironment","volume":"14","author":"Koda","year":"2023","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0084","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.829076","article-title":"Autoimmune and Paraneoplastic Chorea: A Review of the Literature","volume":"13","author":"Kyle","year":"2022","journal-title":"Frontiers in Neurology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0085","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1093\/nop\/npy038","article-title":"The association of health-related quality of life and cognitive function in patients receiving memantine for the prevention of cognitive dysfunction during whole-brain radiotherapy","volume":"6","author":"Laack","year":"2019","journal-title":"Neuro-Oncology Practice"},{"key":"10.1016\/bs.acr.2026.07.001_bib0086","article-title":"A Systematic Review and Meta-Analysis of the Effectiveness of Neuroprotectants for Paclitaxel-Induced Peripheral Neuropathy","volume":"11","author":"Leen","year":"2021","journal-title":"Frontiers in Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0087","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cell.2013.02.051","article-title":"Role of memantine in adult migraine: a systematic review and network meta-analysis to compare memantine with existing migraine preventive medications","volume":"153","author":"Li","year":"2013","journal-title":"Cell"},{"key":"10.1016\/bs.acr.2026.07.001_bib0088","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1158\/1078-0432.CCR-16-3083","article-title":"Clinically Relevant Concentrations of Anticancer Drugs: A Guide for Nonclinical Studies","volume":"23","author":"Liston","year":"2017","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/bs.acr.2026.07.001_bib0089","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.2147\/NDT.S457591","article-title":"Memantine-Assisted Treatment of N-Methyl-D-Aspartate Receptor Antibody Encephalitis: A Mini Review","volume":"20","author":"Liu","year":"2024","journal-title":"Neuropsychiatric Disease and Treatment,"},{"key":"10.1016\/bs.acr.2026.07.001_bib0090","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.3390\/biom12101365","article-title":"Cisplatin Resistance: Genetic and Epigenetic Factors Involved","volume":"12","author":"Lugones","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/bs.acr.2026.07.001_bib0091","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/s41419-024-07228-x","article-title":"Amantadine against glioma via ROS-mediated apoptosis and autophagy arrest","volume":"15","author":"Luo","year":"2024","journal-title":"Cell Death & Disease"},{"key":"10.1016\/bs.acr.2026.07.001_bib0092","doi-asserted-by":"crossref","first-page":"9463","DOI":"10.1158\/0008-5472.CAN-07-2034","article-title":"Autocrine glutamate signaling promotes glioma cell invasion","volume":"67","author":"Lyons","year":"2007","journal-title":"Cancer Research"},{"key":"10.1016\/bs.acr.2026.07.001_bib0093","doi-asserted-by":"crossref","first-page":"e00405","DOI":"10.1016\/j.heliyon.2017.e00405","article-title":"Paclitaxel induces Stathmin 1 phosphorylation, microtubule stability and apoptosis in acute lymphoblastic leukemia cells","volume":"3","author":"Machado-Neto","year":"2017","journal-title":"Heliyon"},{"key":"10.1016\/bs.acr.2026.07.001_bib0094","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.procbio.2022.09.028","article-title":"Memantine enhances the cisplatin-induced apoptosis in A2780 ovarian cancer cells via CyclinD1 and hTERT inhibition","volume":"122","author":"Mahboubi","year":"2022","journal-title":"Process Biochemistry"},{"key":"10.1016\/bs.acr.2026.07.001_bib169","doi-asserted-by":"crossref","first-page":"Fso365","DOI":"10.4155\/fsoa-2018-0106","article-title":"Use of amantadine as substrate for SSAT-1 activity as a reliable clinical diagnostic assay for breast and lung cancer","volume":"5","author":"Maksymiuk","year":"2019","journal-title":"Future Science OA"},{"key":"10.1016\/bs.acr.2026.07.001_bib0095","doi-asserted-by":"crossref","first-page":"18996","DOI":"10.1038\/s41598-020-76137-8","article-title":"Evolution from adherent to suspension: systems biology of HEK293 cell line development","volume":"10","author":"Malm","year":"2020","journal-title":"Scientific Reports"},{"key":"10.1016\/bs.acr.2026.07.001_bib0096","doi-asserted-by":"crossref","DOI":"10.1093\/noajnl\/vdac078.007","article-title":"BSCI-07: Acetyl-Amantadine as a Diagnostic Biomarker in Patients with Glioblastoma","volume":"4","author":"Mann","year":"2022","journal-title":"Neuro-Oncology Advances"},{"key":"10.1016\/bs.acr.2026.07.001_bib0097","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1016\/j.apsb.2024.03.006","article-title":"Complications and comorbidities associated with antineoplastic chemotherapy: Rethinking drug design and delivery for anticancer therapy","volume":"14","author":"Mao","year":"2024","journal-title":"Acta Pharmaceutica Sinica B"},{"key":"10.1016\/bs.acr.2026.07.001_bib0098","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/cncr.31811","article-title":"Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma","volume":"125","author":"Maraka","year":"2019","journal-title":"Cancer"},{"key":"10.1016\/bs.acr.2026.07.001_bib0099","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.3390\/molecules25174005","article-title":"Memantine Derivatives as Multitarget Agents in Alzheimer's Disease","volume":"25","author":"Marotta","year":"2020","journal-title":"Molecules,"},{"key":"10.1016\/bs.acr.2026.07.001_bib0100","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12885-023-11797-z","article-title":"A phase Ib\/II randomized, open-label drug repurposing trial of glutamate signaling inhibitors in combination with chemoradiotherapy in patients with newly diagnosed glioblastoma: the GLUGLIO trial protocol","volume":"24","author":"Mastall","year":"2024","journal-title":"BMC Cancer"},{"key":"10.1016\/bs.acr.2026.07.001_bib0101","doi-asserted-by":"crossref","first-page":"10830","DOI":"10.3390\/ijms241310830","article-title":"Hormone-Dependent Cancers: New Aspects on Biochemistry and Molecular Pathology","volume":"24","author":"Miki","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0102","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s13063-024-08078-w","article-title":"5-EPIFAT trial protocol: a multi-center, randomized, placebo-controlled trial of the efficacy of pharmacotherapy for fatigue using methylphenidate, bupropion, ginseng, and amantadine in advanced cancer patients on active treatment","volume":"25","author":"Miladinia","year":"2024","journal-title":"Trials"},{"key":"10.1016\/bs.acr.2026.07.001_bib0103","doi-asserted-by":"crossref","DOI":"10.1016\/j.apjon.2023.100334","article-title":"Chemotherapy-related cognitive impairment: What we need to know and what we can do","volume":"11","author":"Miyashita","year":"2024","journal-title":"Asia-Pacific Journal of Oncology Nursing"},{"key":"10.1016\/bs.acr.2026.07.001_bib0104","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1136\/spcare-2024-005337","article-title":"Prophylactic effect of memantine in docetaxel induced neuropathy in patients with breast cancer","volume":"15","author":"Mohammadzadeh","year":"2021","journal-title":"BMJ Supportive Palliative Care"},{"key":"10.1016\/bs.acr.2026.07.001_bib0105","doi-asserted-by":"crossref","first-page":"6","DOI":"10.37549\/ARO1119","article-title":"Strategies to mitigate the effects of whole-brain radiation therapy on neurocognitive function in patients with brain metastases","volume":"6","author":"Moraes","year":"2017","journal-title":"Applied Radiation Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0106","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejphar.2016.10.032","article-title":"The effect of memantine on trinitrobenzene sulfonic acid-induced ulcerative colitis in mice","volume":"793","author":"Motaghi","year":"2016","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0107","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.3748\/wjg.v26.i28.4036","article-title":"Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations","volume":"26","author":"Mpilla","year":"2020","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0108","doi-asserted-by":"crossref","first-page":"8172","DOI":"10.1002\/cam4.5619","article-title":"A phase II single-arm trial of memantine for prevention of cognitive decline during chemotherapy in patients with early breast cancer: Feasibility, tolerability, acceptability, and preliminary effects","volume":"12","author":"Nakamura","year":"2023","journal-title":"Cancer Medicine"},{"key":"10.1016\/bs.acr.2026.07.001_bib0109","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1556\/2060.106.2019.22","article-title":"Glioblastoma invasion and NMDA receptors: A novel prospect","volume":"106","author":"Nandakumar","year":"2019","journal-title":"Physiology International"},{"key":"10.1016\/bs.acr.2026.07.001_bib0110","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jtho.2021.11.003","article-title":"The 2021 WHO Classification of Lung Tumors: Impact of Advances since 2015","volume":"17","author":"Nicholson","year":"2022","journal-title":"Journal of Thoracic Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0111","first-page":"31","article-title":"NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment","volume":"2","author":"North","year":"2010","journal-title":"Clinical Pharmacology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0112","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10549-009-0556-1","article-title":"Breast cancer expresses functional NMDA receptors","volume":"122","author":"North","year":"2010","journal-title":"Breast Cancer Research and Treatment"},{"key":"10.1016\/bs.acr.2026.07.001_bib0113","first-page":"15","article-title":"Small-cell lung cancer growth inhibition: synergism between NMDA receptor blockade and chemotherapy","volume":"11","author":"North","year":"2019","journal-title":"Clinical Pharmacology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0114","doi-asserted-by":"crossref","first-page":"e848","DOI":"10.1093\/oncolo\/oyae090","article-title":"Cognitive impairment following breast cancer treatments: an umbrella review","volume":"29","author":"Oliva","year":"2024","journal-title":"The Oncologist"},{"key":"10.1016\/bs.acr.2026.07.001_bib0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2019.113118","article-title":"Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions","volume":"324","author":"Ongnok","year":"2020","journal-title":"Experimental Neurology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0116","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3344\/kjp.2010.23.3.179","article-title":"Antinociceptive Effect of Memantine and Morphine on Vincristine-induced Peripheral Neuropathy in Rats","volume":"23","author":"Park","year":"2010","journal-title":"The Korean Journal of Pain"},{"key":"10.1016\/bs.acr.2026.07.001_bib0117","doi-asserted-by":"crossref","first-page":"224","DOI":"10.14802\/jmd.23037","article-title":"Investigation of the Long-Term Effects of Amantadine Use in Parkinson's Disease","volume":"16","author":"Park","year":"2023","journal-title":"Journal of Movement Disorders"},{"key":"10.1016\/bs.acr.2026.07.001_bib0118","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1055\/s-0043-1769754","article-title":"Stereotactic Radiosurgery as Treatment for Brain Metastases: An Update","volume":"18","author":"Pe\u00f1a-Pino","year":"2023","journal-title":"Asian Journal of Neurosurgery"},{"key":"10.1016\/bs.acr.2026.07.001_bib0119","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1608934","article-title":"Mechanisms of autoimmune-mediated paraneoplastic syndromes: immune tolerance and disease pathogenesis","volume":"16","author":"P\u00e9rez-Bucio","year":"2025","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0120","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.3390\/cancers16173082","article-title":"Cisplatin Resistance and Metabolism: Simplification of Complexity","volume":"16","author":"Pervushin","year":"2024","journal-title":"Cancers (Basel)"},{"key":"10.1016\/bs.acr.2026.07.001_bib0121","doi-asserted-by":"crossref","DOI":"10.1016\/j.rechem.2025.102170","article-title":"Targeting mitochondrial ATP production of glioblastoma using sulfonamide and amide analogs of amantadine and memantine as metabolic inhibitors","volume":"15","author":"Philo","year":"2025","journal-title":"Results in Chemistry"},{"key":"10.1016\/bs.acr.2026.07.001_bib0122","article-title":"Synthesis and Biological Evaluation of a Library of Sulfonamide Analogs of Memantine to Target Glioblastoma","volume":"18","author":"Philo","year":"2023","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/bs.acr.2026.07.001_bib0123","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s40265-015-0400-3","article-title":"Memantine extended release (28 mg once daily): a review of its use in Alzheimer's disease","volume":"75","author":"Plosker","year":"2015","journal-title":"Drugs"},{"key":"10.1016\/bs.acr.2026.07.001_bib0124","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","article-title":"The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises","volume":"161","author":"Raja","year":"2020","journal-title":"Pain,"},{"key":"10.1016\/bs.acr.2026.07.001_bib0125","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1001\/jama.2025.0228","article-title":"Prostate Cancer: A Review","volume":"333","author":"Raychaudhuri","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/bs.acr.2026.07.001_bib0126","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-020-00243-0","article-title":"Prostate cancer","volume":"7","author":"Rebello","year":"2021","journal-title":"Nature Reviews Disease Primers"},{"key":"10.1016\/bs.acr.2026.07.001_bib0127","doi-asserted-by":"crossref","first-page":"6234","DOI":"10.21037\/jtd.2020.03.90","article-title":"Radiosurgery for small-cell lung cancer brain metastases: a review","volume":"12","author":"Robin","year":"2020","journal-title":"Journal of Thoracic Disease"},{"key":"10.1016\/bs.acr.2026.07.001_bib0128","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1200\/JOP.2016.014225","article-title":"Multidisciplinary Care of Laryngeal Cancer","volume":"12","author":"Salvador-Coloma","year":"2016","journal-title":"Journal of Oncology Practice"},{"key":"10.1016\/bs.acr.2026.07.001_bib0129","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.21037\/atm-20-3022a","article-title":"Endometriosis-associated ovarian carcinomas: insights into pathogenesis, diagnostics, and therapeutic targets\u2014a narrative review","volume":"8","author":"Samartzis","year":"2020","journal-title":"Annals of Translational Medicine"},{"key":"10.1016\/bs.acr.2026.07.001_bib0130","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1001\/jama.2023.0023","article-title":"Glioblastoma and Other Primary Brain Malignancies in Adults: A Review","volume":"329","author":"Schaff","year":"2023","journal-title":"JAMA"},{"key":"10.1016\/bs.acr.2026.07.001_bib0131","first-page":"41","article-title":"The cytotoxic effect of memantine and its effect on cytoskeletal proteins expression in metastatic breast cancer cell line","volume":"20","author":"Seifabadi","year":"2017","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0132","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15761\/IMM.1000317","article-title":"Effects of memantine on the growth and protein profiles of neuroblastoma cells","volume":"5","author":"Sekiguchi","year":"2018","journal-title":"Integrative Molecular Medicine"},{"key":"10.1016\/bs.acr.2026.07.001_bib0133","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1244035","article-title":"A review of the therapeutic potential of histone deacetylase inhibitors in rhabdomyosarcoma","volume":"13","author":"Selim","year":"2023","journal-title":"Frontiers in Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0134","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174455","article-title":"Memantine and its benefits for cancer, cardiovascular and neurological disorders","volume":"910","author":"Shafiei-Irannejad","year":"2021","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0135","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.biologicals.2008.02.002","article-title":"The tumorigenicity diversification in human embryonic kidney 293 cell line cultured in vitro","volume":"36","author":"Shen","year":"2008","journal-title":"Biologicals"},{"key":"10.1016\/bs.acr.2026.07.001_bib0136","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.18632\/aging.204071","article-title":"Comprehensive analysis of histone deacetylases genes in the prognosis and immune infiltration of glioma patients","volume":"14","author":"Shen","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/bs.acr.2026.07.001_bib0137","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41392-025-02299-4","article-title":"Glioblastoma at the crossroads: current understanding and future therapeutic horizons","volume":"10","author":"Singh","year":"2025","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"10.1016\/bs.acr.2026.07.001_bib0138","doi-asserted-by":"crossref","first-page":"e14638","DOI":"10.1111\/cbdd.14638","article-title":"Recent Advances in Medicinal Chemistry of Memantine Against Alzheimer's Disease","volume":"104","author":"Singh","year":"2024","journal-title":"Chemical Biology & Drug Design"},{"key":"10.1016\/bs.acr.2026.07.001_bib0139","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2024.105874","article-title":"Amantadine mitigates the cytotoxic and genotoxic effects of doxorubicin in SH-SY5Y cells and reduces its mutagenicity","volume":"99","author":"Soares","year":"2024","journal-title":"Toxicology In Vitro"},{"key":"10.1016\/bs.acr.2026.07.001_bib0140","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.3390\/biomedicines12112631","article-title":"The Role of HDAC6 in Glioblastoma Multiforme: A New Avenue to Therapeutic Interventions?","volume":"12","author":"Spallotta","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/bs.acr.2026.07.001_bib0141","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119527","article-title":"A comprehensive review on time-tested anticancer drug doxorubicin","volume":"278","author":"Sritharan","year":"2021","journal-title":"Life Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0142","first-page":"565","article-title":"Glutamate receptors in laryngeal cancer cells","volume":"31","author":"Stepulak","year":"2011","journal-title":"Anticancer Research"},{"key":"10.1016\/bs.acr.2026.07.001_bib0143","doi-asserted-by":"crossref","first-page":"15605","DOI":"10.1073\/pnas.0507679102","article-title":"NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth","volume":"102","author":"Stepulak","year":"2005","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0144","doi-asserted-by":"crossref","first-page":"4177","DOI":"10.3390\/cancers13164177","article-title":"Memantine Protects against Paclitaxel-Induced Cognitive Impairment through Modulation of Neurogenesis and Inflammation in Mice","volume":"13","author":"Sung","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"1998","key":"10.1016\/bs.acr.2026.07.001_bib0145","first-page":"337","article-title":"Comments on Eisenberg and Pud","volume":"74","author":"Taira","year":"1998","journal-title":"PAIN"},{"key":"10.1016\/bs.acr.2026.07.001_bib0146","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/nm0901-1010","article-title":"Glutamate release promotes growth of malignant gliomas","volume":"7","author":"Takano","year":"2001","journal-title":"Nature Medicine"},{"key":"10.1016\/bs.acr.2026.07.001_bib0147","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/ibra.12098","article-title":"Basic information about memantine and its treatment of Alzheimer's disease and other clinical applications","volume":"9","author":"Tang","year":"2023","journal-title":"Ibrain"},{"key":"10.1016\/bs.acr.2026.07.001_bib0148","article-title":"Research progress in endometriosis-associated ovarian cancer","volume":"14","author":"Tang","year":"2024","journal-title":"Frontiers in Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib171","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.3390\/ijms23031258","article-title":"The Association between Spermidine\/Spermine N(1)-Acetyltransferase (SSAT) and human malignancies","volume":"23","author":"Tse","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0149","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcrpr.2016.08.003","article-title":"Immunotherapy for anti-NMDAR encephalitis: A review of paraneoplastic, autoimmune encephalopathy","volume":"4","author":"Tzang","year":"2017","journal-title":"Journal of Cancer Research and Practice"},{"key":"10.1016\/bs.acr.2026.07.001_bib0150","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.bbr.2011.08.006","article-title":"Persistent cognitive deficits, induced by intrathecal methotrexate, are associated with elevated CSF concentrations of excitotoxic glutamate analogs and can be reversed by an NMDA antagonist","volume":"225","author":"Vijayanathan","year":"2011","journal-title":"Behavioral Brain Research"},{"key":"10.1016\/bs.acr.2026.07.001_bib0151","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s40364-023-00514-4","article-title":"Identification of GRIN2D as a novel therapeutic target in pancreatic ductal adenocarcinoma","volume":"11","author":"Wang","year":"2023","journal-title":"Biomarker Research"},{"key":"10.1016\/bs.acr.2026.07.001_bib0152","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.1080\/21655979.2022.2026553","article-title":"Memantine ameliorates oxaliplatin-induced neurotoxicity via mitochondrial protection","volume":"13","author":"Wang","year":"2022","journal-title":"Bioengineered"},{"key":"10.1016\/bs.acr.2026.07.001_bib0153","first-page":"275","article-title":"Memantine therapy in a patient with severe anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis","author":"Wei","year":"2014","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0154","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/s41598-022-05682-1","article-title":"Prevalence of cognitive impairment following chemotherapy treatment for breast cancer: a systematic review and meta-analysis","volume":"12","author":"Whittaker","year":"2022","journal-title":"Scientific Reports"},{"key":"10.1016\/bs.acr.2026.07.001_bib0155","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/neuonc\/nox195","article-title":"Radiation-induced cognitive toxicity: pathophysiology and interventions to reduce toxicity in adults","volume":"20","author":"Wilke","year":"2018","journal-title":"Neuro-Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0156","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1124\/jpet.112.191957","article-title":"Preclinical predictors of anticancer drug efficacy: critical assessment with emphasis on whether nanomolar potency should be required of candidate agents","volume":"341","author":"Wong","year":"2012","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/bs.acr.2026.07.001_bib0157","doi-asserted-by":"crossref","first-page":"50986","DOI":"10.18632\/oncotarget.9653","article-title":"A pilot study using dynamic contrast enhanced-MRI as a response biomarker of the radioprotective effect of memantine in patients receiving whole brain radiotherapy","volume":"7","author":"Wong","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/bs.acr.2026.07.001_bib0158","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116978","article-title":"Mitigating radiation-induced brain injury via NLRP3\/NLRC4\/Caspase-1 pyroptosis pathway: Efficacy of memantine and hydrogen-rich water","volume":"177","author":"Xu","year":"2024","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/bs.acr.2026.07.001_bib0159","first-page":"80","article-title":"International Antitumor effect of memantine is related to the formation of the splicing isoform of GLG1, a decoy FGFbinding protein","volume":"61","author":"Yamaguchi","year":"2022","journal-title":"Journal of Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0160","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41576-022-00562-w","article-title":"Autophagy genes in biology and disease","volume":"24","author":"Yamamoto","year":"2023","journal-title":"Nature Reviews Genetics"},{"key":"10.1016\/bs.acr.2026.07.001_bib0161","doi-asserted-by":"crossref","first-page":"854","DOI":"10.3171\/2013.12.JNS13641","article-title":"Efficacy of local polymer-based and systemic delivery of the anti-glutamatergic agents riluzole and memantine in rat glioma models","volume":"120","author":"Yohay","year":"2014","journal-title":"Journal of Neurosurgery"},{"key":"10.1016\/bs.acr.2026.07.001_bib0162","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3340\/jkns.2016.0101.006","article-title":"Memantine Induces NMDAR1-Mediated Autophagic Cell Death in Malignant Glioma Cells","volume":"60","author":"Yoon","year":"2017","journal-title":"Journal of Korean Neurosurgical Society"},{"key":"10.1016\/bs.acr.2026.07.001_bib0163","article-title":"NMDAR antagonists suppress tumor progression by regulating tumor-associated macrophages","volume":"120","author":"Yuan","year":"2023","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.acr.2026.07.001_bib0164","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.3390\/ijms20061451","article-title":"Mechanisms of Chemotherapy-Induced Peripheral Neuropathy","volume":"20","author":"Zaj\u0105czkowska","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/bs.acr.2026.07.001_bib0165","article-title":"Tumor-associated macrophages in hepatocellular carcinoma: Cellular plasticity and therapy resistance in crosstalk","volume":"78","author":"Zhang","year":"2026","journal-title":"Neoplasia"},{"key":"10.1016\/bs.acr.2026.07.001_bib170","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.nucmedbio.2012.02.008","article-title":"Preliminary studies of (99m)Tc-memantine derivatives for NMDA receptor imaging","volume":"39","author":"Zhou","year":"2012","journal-title":"Nuclear Medical Biology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0166","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/08880018.2021.1894277","article-title":"Early Decline of Neuron-Specific Enolase during Neuroblastoma Chemotherapy is a Predictive Factor of Clinical Outcome","volume":"38","author":"Zhu","year":"2021","journal-title":"Pediatric Hematology and Oncology"},{"key":"10.1016\/bs.acr.2026.07.001_bib0167","article-title":"Small-cell lung cancer brain metastasis: From molecular mechanisms to diagnosis and treatment","volume":"1868","author":"Zhu","year":"2022","journal-title":"Biochimica et Biophysica Acta (BBA)\u2014Molecular Basis of Disease"}],"container-title":["Advances in Cancer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065230X26000692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065230X26000692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T08:07:34Z","timestamp":1789546054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065230X26000692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443432385"],"references-count":170,"URL":"https:\/\/doi.org\/10.1016\/bs.acr.2026.07.001","relation":{},"ISSN":["0065-230X"],"issn-type":[{"value":"0065-230X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}