{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:02:58Z","timestamp":1789660978679,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier","isbn-type":[{"value":"9780443470523","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.ai.2026.03.001","type":"book-chapter","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:07:40Z","timestamp":1774926460000},"page":"193-212","source":"Crossref","is-referenced-by-count":0,"title":["Microbial biomarkers for OPMD progression"],"prefix":"10.1016","author":[{"given":"Jing-Wen","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujue","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilanand","family":"Chaurasia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/bs.ai.2026.03.001_bib1","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1038\/ismej.2012.174","article-title":"The subgingival microbiome in health and periodontitis and its relationship with community biomass and inflammation","volume":"7","author":"Abusleme","year":"2013","journal-title":"The ISME Journal"},{"key":"10.1016\/bs.ai.2026.03.001_bib2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.oraloncology.2017.03.012","article-title":"Malignant transformation of oral lichen planus and oral lichenoid lesions: A meta-analysis of 20095 patient data","volume":"68","author":"Aghbari","year":"2017","journal-title":"Oral Oncology"},{"key":"10.1016\/bs.ai.2026.03.001_bib3","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.3389\/fmicb.2017.02391","article-title":"The microbiome of potentially malignant oral leukoplakia exhibits enrichment for Fusobacterium, Leptotrichia, Campylobacter, and Rothia species","volume":"8","author":"Amer","year":"2017","journal-title":"Frontiers in Microbiology"},{"issue":"1","key":"10.1016\/bs.ai.2026.03.001_bib4","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2020.1743066","article-title":"Acetaldehyde production by Rothia mucilaginosa isolates from patients with oral leukoplakia","volume":"12","author":"Amer","year":"2020","journal-title":"Journal of Oral Microbiology"},{"issue":"1","key":"10.1016\/bs.ai.2026.03.001_bib5","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2022.2161726","article-title":"Metataxonomic and metaproteomic profiling of the oral microbiome in oral lichen planus-A pilot study","volume":"15","author":"Bankvall","year":"2023","journal-title":"Journal of Oral Microbiology"},{"issue":"26","key":"10.1016\/bs.ai.2026.03.001_bib6","doi-asserted-by":"crossref","first-page":"22613","DOI":"10.18632\/oncotarget.4209","article-title":"Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model","volume":"6","author":"Binder Gallimidi","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/bs.ai.2026.03.001_bib7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1475-2867-13-31","article-title":"Oral squamous cell carcinoma in relation to field precancerisation: pathobiology","volume":"13","author":"Feller","year":"2013","journal-title":"Cancer Cell International"},{"issue":"3","key":"10.1016\/bs.ai.2026.03.001_bib8","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1002\/ijc.32152","article-title":"Periodontal pathogens are a risk factor of oral cavity squamous cell carcinoma, independent of tobacco and alcohol and human papillomavirus","volume":"145","author":"Ganly","year":"2019","journal-title":"International Journal of Cancer"},{"issue":"2","key":"10.1016\/bs.ai.2026.03.001_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3390\/metabo10020047","article-title":"Salivary metabolomics: From diagnostic biomarker discovery to investigating biological function","volume":"10","author":"Gardner","year":"2020","journal-title":"Metabolites"},{"issue":"20","key":"10.1016\/bs.ai.2026.03.001_bib10","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.3390\/cancers16203545","article-title":"The intersection of the oral microbiome and salivary metabolites in head and neck cancer: From diagnosis to treatment","volume":"16","author":"Gonzalez Agurto","year":"2024","journal-title":"Cancers"},{"issue":"1","key":"10.1016\/bs.ai.2026.03.001_bib11","doi-asserted-by":"crossref","DOI":"10.1080\/20002297.2020.1857998","article-title":"Salivary bacterial shifts in oral leukoplakia resemble the dysbiotic oral cancer bacteriome","volume":"13","author":"Gopinath","year":"2020","journal-title":"Journal of Oral Microbiology"},{"key":"10.1016\/bs.ai.2026.03.001_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2025.107583","article-title":"The interplay of hypoxia, inflammation, and microbiota as indicators of malignant transformation in oral potentially malignant disorders","volume":"168","author":"Gurizzan","year":"2025","journal-title":"Oral Oncology"},{"key":"10.1016\/bs.ai.2026.03.001_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-4614-0106-3_5","article-title":"Pathogenic microbes and community service through manipulation of innate immunity","volume":"946","author":"Hajishengallis","year":"2012","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"4","key":"10.1016\/bs.ai.2026.03.001_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/jicd.12445","article-title":"Changes in oral microbial profiles associated with oral squamous cell carcinoma vs leukoplakia","volume":"10","author":"Hashimoto","year":"2019","journal-title":"Journal of Investigative and Clinical Dentistry"},{"issue":"7","key":"10.1016\/bs.ai.2026.03.001_bib15","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1111\/odi.13420","article-title":"Oral bacterial diversity is inversely correlated with mucosal inflammation","volume":"26","author":"Hijazi","year":"2020","journal-title":"Oral Diseases"},{"key":"10.1016\/bs.ai.2026.03.001_bib16","doi-asserted-by":"crossref","first-page":"e6","DOI":"10.1016\/j.oraloncology.2016.03.007","article-title":"Changes in the salivary microbiota of oral leukoplakia and oral cancer","volume":"56","author":"Hu","year":"2016","journal-title":"Oral Oncology"},{"key":"10.1016\/bs.ai.2026.03.001_bib17","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/hed.26006","article-title":"Potentially malignant disorders of the oral cavity and oral dysplasia: A systematic review and meta-analysis of malignant transformation rate by subtype","volume":"42","author":"Iocca","year":"2020","journal-title":"Head & Neck"},{"issue":"1","key":"10.1016\/bs.ai.2026.03.001_bib18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/odi.13209","article-title":"Discrimination of oral squamous cell carcinoma from oral lichen planus by salivary metabolomics","volume":"26","author":"Ishikawa","year":"2020","journal-title":"Oral Diseases"},{"issue":"1","key":"10.1016\/bs.ai.2026.03.001_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Research"},{"issue":"9","key":"10.1016\/bs.ai.2026.03.001_bib20","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.3390\/cancers15092537","article-title":"Rate of malignant transformation differs based on diagnostic criteria for oral lichenoid conditions: A systematic review and meta-analysis of 24,277 patients","volume":"15","author":"Li","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/bs.ai.2026.03.001_bib21","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/s41368-023-00264-x","article-title":"Omics for deciphering oral microecology","volume":"16","author":"Lin","year":"2024","journal-title":"International Journal of Oral Science"},{"key":"10.1016\/bs.ai.2026.03.001_bib22","article-title":"Metabolic and microbial alterations in oral potentially malignant disorders versus oral squamous cell carcinoma","volume":"15","author":"Liu","year":"2025","journal-title":"Scientific Reports"},{"issue":"12","key":"10.1016\/bs.ai.2026.03.001_bib23","doi-asserted-by":"crossref","first-page":"2899","DOI":"10.3390\/biomedicines12122899","article-title":"Metabolomic profiling of oral potentially malignant disorders and its clinical values","volume":"12","author":"Mohd Faizal","year":"2024","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/bs.ai.2026.03.001_bib24","first-page":"1","article-title":"The oral microbiome community variations associated with normal, potentially malignant disorders and malignant lesions of the oral cavity","volume":"39","author":"Mok","year":"2017","journal-title":"The Malaysian Journal of Pathology"},{"key":"10.1016\/bs.ai.2026.03.001_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2020.104632","article-title":"Screening for oral cancer: Future prospects, research and policy development for Asia","volume":"105","author":"Nagao","year":"2020","journal-title":"Oral Oncology"},{"key":"10.1016\/bs.ai.2026.03.001_bib26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-011811-132421","article-title":"Human microbiome in health and disease","volume":"7","author":"Pflughoeft","year":"2012","journal-title":"Annual Review of Pathology"},{"issue":"17","key":"10.1016\/bs.ai.2026.03.001_bib27","doi-asserted-by":"crossref","first-page":"4439","DOI":"10.3390\/cancers13174439","article-title":"Leukoplakia in the oral cavity and oral microbiota: A comprehensive review","volume":"13","author":"Pietrobon","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/bs.ai.2026.03.001_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.archoralbio.2024.105891","article-title":"Oral bacteriome and oral potentially malignant disorders: A systematic review of the associations","volume":"160","author":"Pignatelli","year":"2024","journal-title":"Archives of Oral Biology"},{"key":"10.1016\/bs.ai.2026.03.001_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1198269","article-title":"The emerging role of oral microbiota in oral cancer initiation, progression and stemness","volume":"14","author":"Saikia","year":"2023","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.ai.2026.03.001_bib30","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q","article-title":"Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin","volume":"6","author":"Slaughter","year":"1953","journal-title":"Cancer"},{"issue":"8","key":"10.1016\/bs.ai.2026.03.001_bib31","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1902\/jop.1971.42.8.485","article-title":"The oral microbiota of man from birth to senility","volume":"42","author":"Socransky","year":"1971","journal-title":"Journal of Periodontology"},{"issue":"12","key":"10.1016\/bs.ai.2026.03.001_bib32","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1177\/0022034515606045","article-title":"Oral microbiome metabolism","volume":"94","author":"Takahashi","year":"2015","journal-title":"Journal of Dental Research"},{"issue":"4\u20135","key":"10.1016\/bs.ai.2026.03.001_bib33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.oraloncology.2008.05.016","article-title":"Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management","volume":"45","author":"van der Waal","year":"2009","journal-title":"Oral Oncology"},{"issue":"3191","key":"10.1016\/bs.ai.2026.03.001_bib34","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1126\/science.123.3191.309","article-title":"On the origin of cancer cells","volume":"123","author":"Warburg","year":"1956","journal-title":"Science (New York, N. Y.)"},{"issue":"3","key":"10.1016\/bs.ai.2026.03.001_bib35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/jop.12339","article-title":"Malignant transformation of oral leukoplakia: A systematic review of observational studies","volume":"45","author":"Warnakulasuriya","year":"2016","journal-title":"Journal of Oral Pathology & Medicine"},{"issue":"10","key":"10.1016\/bs.ai.2026.03.001_bib36","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1600-0714.2007.00582.x","article-title":"Nomenclature and classification of potentially malignant disorders of the oral mucosa","volume":"36","author":"Warnakulasuriya","year":"2007","journal-title":"Journal of Oral Pathology & Medicine"},{"issue":"8","key":"10.1016\/bs.ai.2026.03.001_bib37","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1111\/odi.13704","article-title":"Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification, convened by the WHO collaborating centre for oral cancer","volume":"27","author":"Warnakulasuriya","year":"2021","journal-title":"Oral Diseases"},{"issue":"9","key":"10.1016\/bs.ai.2026.03.001_bib38","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1002\/ijc.25881","article-title":"Salivary metabolite signatures of oral cancer and leukoplakia","volume":"129","author":"Wei","year":"2011","journal-title":"International Journal of Cancer"},{"issue":"7","key":"10.1016\/bs.ai.2026.03.001_bib39","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nrd.2016.32","article-title":"Emerging applications of metabolomics in drug discovery and precision medicine","volume":"15","author":"Wishart","year":"2016","journal-title":"Nature Reviews. Drug Discovery"},{"key":"10.1016\/bs.ai.2026.03.001_bib40","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1111\/odi.15317","article-title":"Microbiome signatures and dysbiotic patterns in oral cancer and precancerous lesions","volume":"31","author":"Yang","year":"2025","journal-title":"Oral Diseases"},{"issue":"2","key":"10.1016\/bs.ai.2026.03.001_bib41","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/odi.13545","article-title":"Oral microbiota alteration associated with oral cancer and areca chewing","volume":"27","author":"Zhong","year":"2021","journal-title":"Oral Diseases"},{"issue":"2","key":"10.1016\/bs.ai.2026.03.001_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009321","article-title":"Oral biofilm architecture on natural teeth","volume":"5","author":"Zijnge","year":"2010","journal-title":"PLoS One"}],"container-title":["Advances in Immunology","Microbiome in Head and Neck Cancer: Pathogenesis, Diagnosis and Pathogenesis, Diagnosis and Therapeutic Implications: Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065277626000027?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065277626000027?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:10:39Z","timestamp":1789657839000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065277626000027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443470523"],"references-count":42,"URL":"https:\/\/doi.org\/10.1016\/bs.ai.2026.03.001","relation":{},"ISSN":["0065-2776"],"issn-type":[{"value":"0065-2776","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}