{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:58:45Z","timestamp":1789192725840,"version":"build-2803163510"},"reference-count":167,"publisher":"Elsevier","isbn-type":[{"value":"9780128103951","type":"print"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1016\/bs.apar.2016.02.014","type":"book-chapter","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T05:59:08Z","timestamp":1459576748000},"page":"465-518","source":"Crossref","is-referenced-by-count":26,"title":["Gaining Insights Into the Pharmacology of Anthelmintics Using Haemonchus contortus as a Model Nematode"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.apar.2016.02.014_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0020-7519(94)E0055-R","article-title":"The effect of reduced feed intake on the efficacy of oxfendazole against benzimidazole resistant Haemonchus contortus and Trichostrongylus colubriformis in sheep","volume":"25","author":"Al\u00ed","year":"1995","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.vetpar.2004.03.007","article-title":"Efficacy of abamectin against ivermectin-resistant strain of Trichostrongylus colubriformis in sheep","volume":"121","author":"Alka","year":"2004","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1046\/j.1365-2885.1999.00194.x","article-title":"In vivo and ex vivo uptake of albendazole and its sulphoxide metabolite by cestode parasites: relationship with their kinetics behaviour in sheep","volume":"22","author":"Alvarez","year":"1999","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0304-4017(00)00320-4","article-title":"Uptake of albendazole and albendazole sulphoxide by Haemonchus contortus and Fasciola hepatica in sheep","volume":"94","author":"Alvarez","year":"2000","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib5","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s004360100471","article-title":"Ex vivo diffusion of albendazole and its sulphoxide metabolite into Ascaris suum and Fasciola hepatica","volume":"87","author":"Alvarez","year":"2001","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2016.02.014_bib6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1017\/S0031182003004281","article-title":"Comparative assessment of the access of albendazole, fenbendazole and triclabendazole to Fasciola hepatica: effect of bile in the incubation medium","volume":"128","author":"Alvarez","year":"2004","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2016.02.014_bib7","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1017\/S0031182005007997","article-title":"Altered drug influx\/efflux and enhanced metabolic activity in triclabendazole-resistant liver flukes","volume":"131","author":"Alvarez","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2016.02.014_bib170","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1365-2885.2008.00953.x","article-title":"Evaluation of the interaction between ivermectin and albendazole following their combined use in lambs","volume":"31","author":"Alvarez","year":"2008","journal-title":"Journal of Veterinary Pharmacology and Therapeutics"},{"key":"10.1016\/bs.apar.2016.02.014_bib8","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1645\/GE-2524.1","article-title":"Albendazole failure to control resistant nematodes in lambs: lack of effect of fasting-induced improvement on drug absorption","volume":"96","author":"Alvarez","year":"2010","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2885.2011.01326.x","article-title":"Dose-dependent systemic exposure of albendazole metabolites in lambs","volume":"35","author":"Alvarez","year":"2012","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.vetpar.2015.03.001","article-title":"Integrated assessment of ivermectin pharmacokinetics, efficacy against resistant Haemonchus contortus and P-glycoprotein expression in lambs treated at three different dosage levels","volume":"210","author":"Alvarez","year":"2015","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib11","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1007\/s004360050658","article-title":"Enhanced absorption of pour-on ivermectin formulation in rats by co-administration of the multidrug-resistant-reversing agent verapamil","volume":"85","author":"Alvinerie","year":"1999","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2016.02.014_bib12","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s004360100408","article-title":"In vitro metabolism of moxidectin in Haemonchus contortus adult stages","volume":"87","author":"Alvinerie","year":"2001","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2016.02.014_bib13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.vetpar.2008.06.017","article-title":"Ketoconazole increases the plasma levels of ivermectin in sheep","volume":"157","author":"Alvinerie","year":"2008","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib14","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1751-0813.1988.tb07355.x","article-title":"Mixtures of anthelmintics: a strategy against resistance","volume":"65","author":"Anderson","year":"1988","journal-title":"Aust. Vet. J."},{"key":"10.1016\/bs.apar.2016.02.014_bib15","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.vetpar.2012.09.021","article-title":"Inhibition of P-glycoprotein enhances sensitivity of Caenorhabditis elegans to ivermectin","volume":"191","author":"Ardelli","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib17","series-title":"Veterinary Pharmacology and Therapeutics","article-title":"Disposition and fate of drugs in the body","author":"Baggot","year":"1982"},{"key":"10.1016\/bs.apar.2016.02.014_bib18","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1124\/dmd.105.007757","article-title":"Modulation of the P-glycoprotein-mediated intestinal secretion of ivermectin: in vitro and in vivo assessments","volume":"34","author":"Ballent","year":"2006","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/bs.apar.2016.02.014_bib19","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/j.1365-2885.2007.00848.x","article-title":"Involvement of P-glycoprotein on ivermectin kinetic behaviour in sheep: itraconazole-mediated changes on gastrointestinal disposition","volume":"30","author":"Ballent","year":"2007","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib20","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1365-2885.2009.01129.x","article-title":"Pretreatment with the inducers rifampicin and phenobarbital alters ivermectin gastrointestinal disposition","volume":"33","author":"Ballent","year":"2010","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib21","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.tvjl.2011.09.006","article-title":"In vivo and ex vivo assessment of the interaction between ivermectin and danofloxacin in sheep","volume":"192","author":"Ballent","year":"2012","journal-title":"Vet. J."},{"key":"10.1016\/bs.apar.2016.02.014_bib22","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/jvp.12040","article-title":"P-glycoprotein in sheep liver and small intestine: gene expression and transport efflux activity","volume":"36","author":"Ballent","year":"2013","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib23","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0169-4758(95)80117-0","article-title":"Worm control and anthelmintic resistance: adventures with a model","volume":"11","author":"Barnes","year":"1995","journal-title":"Parasitol. Today"},{"key":"10.1016\/bs.apar.2016.02.014_bib24","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.vetpar.2011.11.068","article-title":"Relationship between increased albendazole systemic exposure and changes in single nucleotide polymorphisms on the \u03b2-tubulin isotype 1 encoding gene in Haemonchus contortus","volume":"186","author":"Barr\u00e8re","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib25","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.vetpar.2012.02.008","article-title":"Import and efflux of flubendazole in Haemonchus contortus strains susceptible and resistant to anthelmintics","volume":"187","author":"B\u00e1rt\u00edkov\u00e1","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib26","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1017\/S0031182009990345","article-title":"P-glycoprotein interfering agents potentiate ivermectin susceptibility in ivermectin sensitive and resistant isolates of Teladorsagia circumcincta and Haemonchus contortus","volume":"136","author":"Bartley","year":"2009","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2016.02.014_bib27","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.vetpar.2012.02.011","article-title":"Influence of Pluronic 85 and ketoconazole on disposition and efficacy of ivermectin in sheep infected with a multiple resistant Haemonchus contortus isolate","volume":"187","author":"Bartley","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib28","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/genetics\/138.1.103","article-title":"Genetic variability of the beta-tubulin genes in benzimidazole-susceptible and -resistant strains of Haemonchus contortus","volume":"138","author":"Beech","year":"1994","journal-title":"Genetics"},{"key":"10.1016\/bs.apar.2016.02.014_bib29","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0014-4894(87)90077-4","article-title":"Fasciola hepatica: action in vitro of triclabendazole on immature and adult species","volume":"63","author":"Bennett","year":"1987","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0166-6851(98)00087-5","article-title":"Selection at a P-glycoprotein gene in ivermectin- and moxidectin-selected strains of Haemonchus contortus","volume":"95","author":"Blackhall","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib31","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/expr.1998.4316","article-title":"Haemonchus contortus: selection at a glutamate-gated chloride channel gene in ivermectin- and moxidectin-selected strains","volume":"90","author":"Blackhall","year":"1998","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib33","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/S0034-5288(18)32451-2","article-title":"Pharmacokinetics of levamisole in sheep","volume":"32","author":"Bogan","year":"1982","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/bs.apar.2016.02.014_bib34","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1365-2885.1988.tb00151.x","article-title":"The pharmacodynamics of ivermectin in sheep and cattle","volume":"11","author":"Bogan","year":"1988","journal-title":"J.\u00a0Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib35","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0304-4017(93)90012-C","article-title":"The efficacy and persistent anthelmintic effect of ivermectin in sheep","volume":"50","author":"Borgsteede","year":"1993","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib36","series-title":"Proceedings of the XVIII Congresso Brasileiro de Parasitologia Veterinaria, Gramado, Brasil","article-title":"Evaluation of the combined use of ivermectin and ricobendazole in cattle: pharmacokinetic and\/or pharmacodynamic interactions","author":"Canton","year":"2014"},{"key":"10.1016\/bs.apar.2016.02.014_bib37","series-title":"Proceedings of the 25th International Conference of the World Association for the Advancement of Veterinary Parasitology, Liverpool, UK","article-title":"Assessment of the ricobendazole plus levamisole nematodicidal combination in cattle","author":"Canton","year":"2015"},{"key":"10.1016\/bs.apar.2016.02.014_bib38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.vetpar.2010.06.013","article-title":"Multiple resistance of gastrointestinal nematodes to nine different drugs in a sheep flock in southern Brazil","volume":"173","author":"Cezar","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib39","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1158\/0008-5472.CAN-09-1947","article-title":"Drug combination studies and their synergy quantification using the Chou-Talalay method","volume":"70","author":"Chou","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/bs.apar.2016.02.014_bib40","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1172\/JCI103910","article-title":"Combined drug treatment of tuberculosis. I. Prevention of emergence of mutant populations of tubercle bacilli resistant to both streptomycin and isoniazid in vitro","volume":"38","author":"Conn","year":"1959","journal-title":"J. Clin. Invest."},{"key":"10.1016\/bs.apar.2016.02.014_bib41","series-title":"Veterinary Pharmacology and Therapeutics","article-title":"Antinematodal drugs","author":"Courtney","year":"1995"},{"key":"10.1016\/bs.apar.2016.02.014_bib42","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1080\/00034983.1998.11813331","article-title":"In vitro uptake of ivermectin by adult male Onchocerca ochengi","volume":"92","author":"Cross","year":"1998","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib43","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1111\/j.1751-0813.2001.tb10892.x","article-title":"Principles of use of macrocyclic lactones to minimise selection for resistance","volume":"79","author":"Dobson","year":"2001","journal-title":"Aust. Vet. J."},{"key":"10.1016\/bs.apar.2016.02.014_bib44","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0304-4017(03)00008-6","article-title":"Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin","volume":"112","author":"Dupuy","year":"2003","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib45","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1365-2885.2006.00780.x","article-title":"Fumagillin, a new P-glycoprotein-interfering agent able to modulate moxidectin efflux in rat hepatocytes","volume":"29","author":"Dupuy","year":"2006","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib46","series-title":"Principles of Veterinary Therapeutics","author":"Einstein","year":"1994"},{"key":"10.1016\/bs.apar.2016.02.014_bib47","series-title":"Committee for Medicinal Products for Veterinary Use (CVMP), Guideline on Pharmaceutical Fixed Combination Products","author":"EMEA (European Medicines Agency)","year":"2006"},{"key":"10.1016\/bs.apar.2016.02.014_bib48","series-title":"European Public MRL Assessment Report. Committee for Medicinal Products for Veterinary Use","author":"EMEA (European Medicines Agency)","year":"2010"},{"key":"10.1016\/bs.apar.2016.02.014_bib49","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.vetpar.2008.04.015","article-title":"Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes","volume":"155","author":"Entrocasso","year":"2008","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib50","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/00480169.1998.36084","article-title":"Bioavailability of levamisole after intramuscular and oral administration in sheep","volume":"46","author":"Fern\u00e1ndez","year":"1998","journal-title":"N. Z. Vet. J."},{"key":"10.1016\/bs.apar.2016.02.014_bib51","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0304-4017(93)90051-N","article-title":"Biochemistry of the nematode cuticle: relevance to parasitic nematodes of livestock","volume":"46","author":"Fetterer","year":"1993","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib52","series-title":"Derquantel. Evaluations of the Joint FAO\/WHO Expert Committee on Food Additives (JECFA)","first-page":"1","author":"Friedlander","year":"2012"},{"key":"10.1016\/bs.apar.2016.02.014_bib53","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1751-0813.1983.tb05927.x","article-title":"Seasonal variations in anthelmintic response by cattle to dermally applied levamisole","volume":"60","author":"Forsyth","year":"1983","journal-title":"Aust. Vet. J."},{"key":"10.1016\/bs.apar.2016.02.014_bib54","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1006\/expr.1993.1064","article-title":"Haemonchus contortus: ivermectin-induced paralysis of the pharynx","volume":"77","author":"Geary","year":"1993","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib55","series-title":"Molecular Approaches to Parasitology","first-page":"57","article-title":"Biological functions of nematode surfaces","author":"Geary","year":"1995"},{"key":"10.1016\/bs.apar.2016.02.014_bib56","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.vetpar.2012.09.004","article-title":"World Association for the Advancement of Veterinary Parasitology (W.A.A.V.P.) guideline: anthelmintic combination products targeting nematode infections of ruminants and horses","volume":"190","author":"Geary","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib57","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.vetpar.2012.03.001","article-title":"The comparative efficacy of abamectin, monepantel and an abamectin\/derquantel combination against fourth-stage larvae of a macrocyclic lactone-resistant Teladorsagia spp. isolate infecting sheep","volume":"188","author":"George","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib58","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0020-7519(98)00068-X","article-title":"Avermectin\/milbemycin resistance in trichostrongyloid nematodes","volume":"28","author":"Gill","year":"1998","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib59","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1073\/pnas.0915125107","article-title":"Repositioning of an existing drug for the neglected tropical disease Onchocerciasis","volume":"107","author":"Gloeckner","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/bs.apar.2016.02.014_bib60","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijpara.2014.09.008","article-title":"Haemonchus contortus P-glycoprotein-2: in situ localisation and characterisation of macrocyclic lactone transport","volume":"45","author":"Godoy","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib61","first-page":"635","article-title":"The employment of combinations of drugs in the chemotherapy of neoplasia: a review","volume":"17","author":"Goldin","year":"1957","journal-title":"Cancer Res."},{"key":"10.1016\/bs.apar.2016.02.014_bib62","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/00480169.2001.36220","article-title":"The difference in efficacy of ivermectin oral, moxidectin oral and moxidectin injectable formulations against an ivermectin-resistant strain of Trichostrongylus colubriformis in sheep","volume":"49","author":"Gopal","year":"2001","journal-title":"N. Z. Vet. J."},{"key":"10.1016\/bs.apar.2016.02.014_bib63","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.1365-2885.2005.00655.x","article-title":"Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein","volume":"28","author":"Griffin","year":"2005","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib64","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF02214966","article-title":"The role of absorbed drug in the efficacy of oxfendazole against gastrointestinal nematodes","volume":"5","author":"Hennessy","year":"1981","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/bs.apar.2016.02.014_bib65","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0169-4758(93)90232-5","article-title":"Pharmacokinetic disposition of benzimidazole drugs in the ruminant gastrointestinal tract","volume":"9","author":"Hennessy","year":"1993","journal-title":"Parasitol. Today"},{"key":"10.1016\/bs.apar.2016.02.014_bib66","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0304-4017(97)00106-4","article-title":"Modifying the formulation or delivery mechanism to increase the activity of anthelmintic compounds","volume":"72","author":"Hennessy","year":"1997","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib67","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-4017(99)00205-8","article-title":"WAAVP\/Pfizer award for excellence in veterinary parasitology research. My involvement in, and some thoughts for livestock parasitological research in Australia","volume":"88","author":"Hennessy","year":"2000","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib68","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1046\/j.1365-2885.2000.t01-2-00286.x","article-title":"The behaviour of doramectin in the gastrointestinal tract, its secretion in bile and pharmacokinetic disposition in the peripheral circulation after oral and intravenous administration to sheep","volume":"23","author":"Hennessy","year":"2000","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib69","doi-asserted-by":"crossref","first-page":"e95072","DOI":"10.1371\/journal.pone.0095072","article-title":"Caenorhabditis elegans neuromuscular junction: GABA receptors and ivermectin action","volume":"9","author":"Hernando","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/bs.apar.2016.02.014_bib70","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nature10139","article-title":"Principles of activation and permeation in an anion-selective Cys-loop receptor","volume":"474","author":"Hibbs","year":"2011","journal-title":"Nature"},{"key":"10.1016\/bs.apar.2016.02.014_bib71","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0166-6851(90)90178-O","article-title":"Biophysical transport properties of the cuticle of Ascaris suum","volume":"41","author":"Ho","year":"1990","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0166-6851(92)90031-E","article-title":"Mechanistic studies in the transcuticular delivery of antiparasitic drugs II: ex vivo\/in vitro correlation of solute transport by Ascaris suum","volume":"52","author":"Ho","year":"1992","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib73","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2165\/00003088-198106060-00002","article-title":"Understanding the dose-effect relationship: clinical application of pharmacokinetic-pharmacodynamic models","volume":"6","author":"Holford","year":"1981","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/bs.apar.2016.02.014_bib74","series-title":"The Control of Gastro-intestinal Nematodes in Sheep With the Amino-acetonitrile Derivative, Monepantel With a Particular Focus on Australia and New Zealand","first-page":"115","author":"Hosking","year":"2010"},{"key":"10.1016\/bs.apar.2016.02.014_bib75","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1136\/vr.b4830","article-title":"Effect of route of administration on the efficacy and pharmacokinetics of an experimental formulation of the amino-acetonitrile derivative monepantel in sheep","volume":"166","author":"Hosking","year":"2010","journal-title":"Vet. Rec."},{"key":"10.1016\/bs.apar.2016.02.014_bib76","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature06722","article-title":"A new class of anthelmintics effective against drug-resistant nematodes","volume":"452","author":"Kaminsky","year":"2008","journal-title":"Nature"},{"key":"10.1016\/bs.apar.2016.02.014_bib77","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ijpara.2008.09.009","article-title":"Determination of the effective dose rate for monepantel (AAD 1566) against adult gastro-intestinal nematodes in sheep","volume":"39","author":"Kaminsky","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib78","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00436-010-2216-0","article-title":"Differences in efficacy of monepantel, derquantel and abamectin against multi-resistant nematodes of sheep","volume":"109","author":"Kaminsky","year":"2011","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2016.02.014_bib79","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.vetpar.2011.11.048","article-title":"An inconvenient truth: global worming and anthelmintic resistance","volume":"186","author":"Kaplan","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib80","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1365-2885.2008.01052.x","article-title":"Pharmacokinetics of monepantel and its sulphone metabolite, monepantel suphone, after intravenous and oral administrations in sheep","volume":"32","author":"Karadzovska","year":"2009","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib81","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1128\/AAC.01477-10","article-title":"Anthelmintics are substrates and activators of nematode P glycoprotein","volume":"55","author":"Kerboeuf","year":"2011","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/bs.apar.2016.02.014_bib82","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1124\/dmd.109.030700","article-title":"Role of P-glycoprotein in the disposition of macrocyclic lactones: a comparison between ivermectin, eprinomectin, and moxidectin in mice","volume":"38","author":"Kiki-Mvouaka","year":"2010","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/bs.apar.2016.02.014_bib83","doi-asserted-by":"crossref","first-page":"631","DOI":"10.2307\/3284740","article-title":"Effects of macrocyclic lactones on ingestion in susceptible and resistant Haemonchus contortus larvae","volume":"84","author":"Kotze","year":"1998","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib84","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.vetpar.2005.11.001","article-title":"Synergism of rotenone by piperonyl butoxide in Haemonchus contortus and Trichostrongylus colubriformis in vitro: potential for drug-synergism through inhibition of nematode oxidative detoxification pathways","volume":"136","author":"Kotze","year":"2006","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib85","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijpddr.2011.10.002","article-title":"A reappraisal of the relative sensitivity of nematode pharyngeal and somatic musculature to macrocyclic lactone drugs","volume":"2","author":"Kotze","year":"2012","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/bs.apar.2016.02.014_bib86","doi-asserted-by":"crossref","first-page":"7475","DOI":"10.1128\/AAC.03333-14","article-title":"Phenobarbital induction and chemical synergism demonstrate the role of UDP-glucuronosyltransferases in detoxification of naphthalophos by Haemonchus contortus larvae","volume":"58","author":"Kotze","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/bs.apar.2016.02.014_bib87","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0166-6851(94)90066-3","article-title":"Benzimidazole resistance in Haemonchus contortus is correlated with a conserved mutation at amino acid 200 in \u00df-tubulin isotype 1","volume":"63","author":"Kwa","year":"1994","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib88","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/S0020-7519(98)00071-X","article-title":"Use of P-glycoprotein gene probes to investigate antihelmintic resistance in Haemonchus contortus and comparison with Onchocerca volvulus","volume":"28","author":"Kwa","year":"1998","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib89","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0020-7519(88)90175-0","article-title":"The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles","volume":"18","author":"Lacey","year":"1988","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib90","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0169-4758(90)90227-U","article-title":"Mode of action of benzimidazoles","volume":"6","author":"Lacey","year":"1990","journal-title":"Parasitol. Today"},{"key":"10.1016\/bs.apar.2016.02.014_bib91","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/03602539308993977","article-title":"Clinical pharmacokinetics and metabolism of benzimidazole anthelmintics in ruminants","volume":"25","author":"Lanusse","year":"1993","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/bs.apar.2016.02.014_bib92","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0304-4017(93)90115-4","article-title":"Relationship between pharmacological properties and clinical efficacy of ruminant anthelmintics","volume":"49","author":"Lanusse","year":"1993","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib93","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1365-2885.1993.tb00287.x","article-title":"Gastrointestinal distribution of albendazole metabolites following netobimin administration to cattle: relationship with plasma disposition kinetics","volume":"16","author":"Lanusse","year":"1993","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib94","series-title":"Veterinary Pharmacology and Therapeutics","article-title":"Anticestodal and antitrematodal drugs","author":"Lanusse","year":"2009"},{"key":"10.1016\/bs.apar.2016.02.014_bib95","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.vetpar.2013.11.003","article-title":"Pharmacological knowledge and sustainable anthelmintic therapy in ruminants","volume":"204","author":"Lanusse","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib96","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1080\/00480169.2009.36900","article-title":"Managing anthelmintic resistance: is it feasible in New Zealand to delay the emergence of resistance to a new anthelmintic class?","volume":"57","author":"Leathwick","year":"2009","journal-title":"N. Z. Vet. J."},{"key":"10.1016\/bs.apar.2016.02.014_bib97","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.vetpar.2012.09.020","article-title":"Efficacy of oral, injectable and pour-on formulations of moxidectin against gastrointestinal nematodes in cattle in New Zealand","volume":"191","author":"Leathwick","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib99","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ejps.2006.10.004","article-title":"Interaction of macrocyclic lactones with P-glycoprotein: structure-affinity relationship","volume":"30","author":"Lespine","year":"2007","journal-title":"Eur. J. Pharmacol. Sci."},{"key":"10.1016\/bs.apar.2016.02.014_bib100","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.pt.2008.03.011","article-title":"ABC transporter modulation: a strategy to enhance the activity of macrocyclic lactone anthelmintics","volume":"24","author":"Lespine","year":"2008","journal-title":"Trends Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib101","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ijpddr.2011.10.001","article-title":"P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: prospects for reversing transport-dependent anthelmintic resistance","volume":"2","author":"Lespine","year":"2012","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/bs.apar.2016.02.014_bib102","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1023\/A:1005832412415","article-title":"Enhanced plasma availability of the metabolites of albendazole in fasted adult sheep","volume":"21","author":"Lifschitz","year":"1997","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/bs.apar.2016.02.014_bib103","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0304-4017(99)00175-2","article-title":"Comparative distribution of ivermectin and doramectin to parasite location tissues in cattle","volume":"87","author":"Lifschitz","year":"2000","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib104","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1046\/j.1365-2885.2002.00396.x","article-title":"Loperamide-induced enhancement of moxidectin availability in cattle","volume":"25","author":"Lifschitz","year":"2002","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib105","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.vetpar.2010.04.039","article-title":"Interference with P-glycoprotein improves ivermectin activity against adult resistant nematodes in sheep","volume":"172","author":"Lifschitz","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib106","doi-asserted-by":"crossref","first-page":"912","DOI":"10.2174\/138920112800399211","article-title":"Macrocyclic lactones and cellular transport-related drug interactions: a perspective from in vitro assays to nematode control in the field","volume":"13","author":"Lifschitz","year":"2012","journal-title":"Curr. Pharmacol. Biotechnol."},{"key":"10.1016\/bs.apar.2016.02.014_bib107","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.vetpar.2014.02.049","article-title":"Accumulation of monepantel and its sulphone derivative in tissues of nematode location in sheep: pharmacokinetic support to its excellent nematodicidal activity","volume":"203","author":"Lifschitz","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib108","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0169-409X(02)00171-0","article-title":"Drug-drug interaction mediated by inhibition and induction of P-glycoprotein","volume":"55","author":"Lin","year":"2003","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/bs.apar.2016.02.014_bib109","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.vetpar.2011.05.008","article-title":"Efficacy of a combined oral formulation of derquantel-abamectin against the adult and larval stages of nematodes in sheep, including anthelmintic-resistant strains","volume":"181","author":"Little","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib110","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.exppara.2012.04.014","article-title":"Measurement of ivermectin concentrations in target worms and host gastrointestinal tissues: influence of the route of administration on the activity against resistant Haemonchus contortus in lambs","volume":"131","author":"Lloberas","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib111","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ijpddr.2012.11.001","article-title":"Comparative tissue pharmacokinetics and efficacy of moxidectin, abamectin and ivermectin in lambs infected with resistant nematodes: impact of drug treatments on parasite P-glycoprotein expression","volume":"3","author":"Lloberas","year":"2013","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/bs.apar.2016.02.014_bib112","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1080\/00480169.2015.1015645","article-title":"Comparative pharmacokinetic and pharmacodynamic response of single and double intraruminal doses of ivermectin and moxidectin in nematode-infected lambs","volume":"63","author":"Lloberas","year":"2015","journal-title":"N. Z. Vet. J."},{"key":"10.1016\/bs.apar.2016.02.014_bib113","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0166-6851(90)90025-H","article-title":"Specific interaction of benzimidazole anthelmintic with tubulin: high affinity binding and benzimidazole resistance in Haemonchus contortus","volume":"38","author":"Lubega","year":"1990","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib114","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1090-0233(05)80005-X","article-title":"Modes of action of anthelmintics drugs","volume":"154","author":"Martin","year":"1997","journal-title":"Vet. J."},{"key":"10.1016\/bs.apar.2016.02.014_bib115","series-title":"Macrocyclic Lactones in Antiparasitic Therapy","first-page":"125","article-title":"Mode of action of the macrocyclic lactones","author":"Martin","year":"2002"},{"key":"10.1016\/bs.apar.2016.02.014_bib116","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2460\/ajvr.1980.41.07.1126","article-title":"Pharmacokinetics of albendazole in sheep","volume":"41","author":"Marriner","year":"1980","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/bs.apar.2016.02.014_bib117","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/jvp.12063","article-title":"Bioequivalence accomplishments, ongoing initiatives, and remaining challenges","volume":"37","author":"Martinez","year":"2014","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib118","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bcp.2011.10.010","article-title":"Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line","volume":"83","author":"M\u00e9nez","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/bs.apar.2016.02.014_bib119","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/03602538708998307","article-title":"The metabolism and fate of closantel (Flukiver) in sheep and cattle","volume":"18","author":"Michiels","year":"1987","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/bs.apar.2016.02.014_bib120","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0921-4488(95)00761-X","article-title":"Use of anthelmintic combinations against multiple resistant Haemonchus contortus in Angora goats","volume":"19","author":"Miller","year":"1996","journal-title":"Small Ruminant Res."},{"key":"10.1016\/bs.apar.2016.02.014_bib121","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s004360050673","article-title":"The effects of the multidrug-resistance-reversing agent verapamil and CL347099 on the efficacy of ivermectin or moxidectin against unselected and drug-selected strains of Haemonchus contortus in jirds (Meriones unguiculatus)","volume":"85","author":"Molento","year":"1999","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2016.02.014_bib122","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00436-003-1022-3","article-title":"Influence of verapamil on the pharmacokinetics of the antiparasitic drugs ivermectin and moxidectin in sheep","volume":"92","author":"Molento","year":"2004","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2016.02.014_bib123","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.exppara.2004.03.003","article-title":"Dose-dependent activity of albendazole against benzimidazole-resistant nematodes in sheep: relationship between pharmacokinetics and efficacy","volume":"106","author":"Moreno","year":"2004","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib124","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-4894(03)00060-2","article-title":"Transtegumental diffusion of benzimidazole anthelmintics into Moniezia benedeni: correlation with their octanol-water partition coefficients","volume":"103","author":"Mottier","year":"2003","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib125","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1080\/00498250400015285","article-title":"Triclabendazole biotransformation and comparative diffusion of the parent drug and its oxidized metabolites into Fasciola hepatica","volume":"34","author":"Mottier","year":"2004","journal-title":"Xenobiotica"},{"key":"10.1016\/bs.apar.2016.02.014_bib126","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.exppara.2005.12.004","article-title":"Drug transport mechanisms in helminth parasites: passive diffusion of benzimidazole anthelmintics","volume":"113","author":"Mottier","year":"2006","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib127","series-title":"Principles of Drug Action","first-page":"297","article-title":"The time course of drug action","author":"Neubig","year":"1990"},{"key":"10.1016\/bs.apar.2016.02.014_bib128","first-page":"431","article-title":"The pharmacokinetics of levamisole in goats and pigs. Pharmacologie et toxicologie veterinaire","volume":"8","author":"Nielsen","year":"1982","journal-title":"Les colloques de l'INRA"},{"key":"10.1016\/bs.apar.2016.02.014_bib129","series-title":"The Pharmacological Basis of Therapeutics","first-page":"43","article-title":"Principles of therapeutics","author":"Nies","year":"1996"},{"key":"10.1016\/bs.apar.2016.02.014_bib130","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1046\/j.1365-3156.2001.00777.x","article-title":"Biochemical and molecular mechanisms of drug resistance in parasites","volume":"6","author":"Ouellette","year":"2001","journal-title":"Trop. Med. Int. Health"},{"key":"10.1016\/bs.apar.2016.02.014_bib131","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0020-7519(97)00104-5","article-title":"A new in vitro assay of benzimidazole activity against adult Oesophagostomum dentatum","volume":"27","author":"Petersen","year":"1997","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib132","series-title":"Principles of Drug Action. The Basis of Pharmacology","first-page":"565","article-title":"Drug resistance","author":"Pratt","year":"1990"},{"key":"10.1016\/bs.apar.2016.02.014_bib133","series-title":"Antimicrobial Therapy in Veterinary Medicine","first-page":"3","article-title":"Antimicrobial drug action and interaction: an introduction","author":"Prescott","year":"2000"},{"key":"10.1016\/bs.apar.2016.02.014_bib134","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0304-4017(94)90094-9","article-title":"Anthelmintic resistance","volume":"54","author":"Prichard","year":"1994","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib135","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S1471-4922(01)01983-3","article-title":"Genetic variability following selection of Haemonchus contortus with anthelmintics","volume":"17","author":"Prichard","year":"2001","journal-title":"Trends Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib136","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1017\/S0031182007000091","article-title":"ABC transporters and \u00df-tubulin in macrocyclic lactones resistance: prospects for marker development","volume":"134","author":"Prichard","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2016.02.014_bib137","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ijpddr.2012.04.001","article-title":"Moxidectin and the avermectins: consanguinity but not identity","volume":"2","author":"Prichard","year":"2012","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/bs.apar.2016.02.014_bib138","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.molbiopara.2013.02.004","article-title":"Derquantel and abamectin: effects and interactions on isolated tissues of Ascaris suum","volume":"188","author":"Puttachary","year":"2013","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib139","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.vetpar.2015.04.025","article-title":"Effects of third generation-P-glycoprotein-inhibitors on the sensitivity of drug-resistant and -susceptible isolates of Haemonchus contortus to anthelmintics in vitro","volume":"211","author":"Raza","year":"2015","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib140","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00436-003-1003-6","article-title":"The comparative metabolism of triclabendazole sulphoxide by triclabendazole-susceptible and triclabendazole-resistant Fasciola hepatica","volume":"92","author":"Robinson","year":"2004","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2016.02.014_bib141","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/0020-7519(93)90054-3","article-title":"Kinetics of expulsion of Haemonchus contortus from sheep and jirds after treatment with closantel","volume":"23","author":"Rothwell","year":"1993","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib142","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0020-7519(96)00200-7","article-title":"Haemonchus contortus: the uptake and metabolism of closantel","volume":"27","author":"Rothwell","year":"1997","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib143","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1124\/mol.110.066498","article-title":"Monepantel allosterically activates DEG-3\/DES-2 channels of the gastrointestinal nematode Haemonchus contortus","volume":"78","author":"Rufener","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/bs.apar.2016.02.014_bib144","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.ijpara.2010.11.009","article-title":"Activity of novel nicotinic anthelmintics in cut preparations of Caenorhabditis elegans","volume":"41","author":"Ruiz-Lancheros","year":"2011","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib145","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.vetpar.2010.02.011","article-title":"Quarantine treatment of sheep with monepantel-rapidity of fecal egg count reduction","volume":"170","author":"Sager","year":"2010","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib146","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1046\/j.1365-2885.2000.00258.x","article-title":"Subcutaneous bioavailability of levamisole in goats","volume":"23","author":"Sahagun","year":"2000","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib147","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1046\/j.1365-2885.2001.00369.x","article-title":"Oral bioavailability of levamisole in goats","volume":"24","author":"Sahagun","year":"2001","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/bs.apar.2016.02.014_bib148","first-page":"261","article-title":"The contribution of partial tricarboxylic acid cycle to volatile end-products in thiabendazole-resistant and \u2013susceptible Trichostrongylus colubriformis (Nematoda)","volume":"14","author":"Sangster","year":"1985","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib149","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/0020-7519(88)90123-3","article-title":"Investigation of the mechanism of levamisole resistance in trichostrongylid nematodes of sheep","volume":"18","author":"Sangster","year":"1988","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib150","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0169-4758(99)01413-1","article-title":"Pharmacology of anthelmintic resistance","volume":"15","author":"Sangster","year":"1999","journal-title":"Parasitol. Today"},{"key":"10.1016\/bs.apar.2016.02.014_bib151","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/0959-8049(95)00130-B","article-title":"Multidrug resistance and the role of P-glycoprotein knockout mice","volume":"31","author":"Schinkel","year":"1995","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/bs.apar.2016.02.014_bib152","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/scbi.1997.0068","article-title":"The physiological function of drug-transporting P-glycoproteins","volume":"8","author":"Schinkel","year":"1997","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/bs.apar.2016.02.014_bib153","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.vetpar.2004.12.008","article-title":"Effect of ivermectin on feeding by Haemonchus contortus in vivo","volume":"128","author":"Sheriff","year":"2005","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib154","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0304-4017(94)00743-V","article-title":"Structure and activity of avermectins and milbemycins in animal health","volume":"59","author":"Shoop","year":"1995","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0166-6851(92)90016-D","article-title":"Mechanisms of microenvironmental pH regulation in the cuticle of Ascaris suum","volume":"53","author":"Sims","year":"1992","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib156","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10611869409015888","article-title":"Biophysical model of the transcuticular excretion of organic acids, cuticle pH and buffer capacity in gastrointestinal nematodes","volume":"2","author":"Sims","year":"1992","journal-title":"J. Drug Target"},{"key":"10.1016\/bs.apar.2016.02.014_bib157","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0020-7519(95)00113-1","article-title":"Influence of organic acid excretion on cuticle pH and drug absorption by Haemonchus contortus","volume":"26","author":"Sims","year":"1996","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib158","doi-asserted-by":"crossref","first-page":"187","DOI":"10.2307\/3284141","article-title":"Effect of ivermectin on Caenorhabditis elegans larvae previously exposed to alcoholic immobilization","volume":"82","author":"Smith","year":"1996","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib159","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.vetpar.2013.12.020","article-title":"Combination anthelmintics effectively control ML-resistant parasites; a real-world case history","volume":"204","author":"Smith","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib160","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1002\/dta.1630","article-title":"Metabolic pathways of anthelmintic drug monepantel in sheep and in its parasite (Haemonchus contortus)","volume":"6","author":"Stuchl\u00edkov\u00e1","year":"2014","journal-title":"Drug Test. Analysis"},{"key":"10.1016\/bs.apar.2016.02.014_bib161","series-title":"Proceedings of the 24th International Conference of the World Association for the Advancement of Veterinary Parasitology, Perth, Australia","article-title":"Pharmaco-therapeutic evaluation of the closantel-moxidectin combination in lambs","author":"Suarez","year":"2013"},{"key":"10.1016\/bs.apar.2016.02.014_bib162","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.vetpar.2013.12.015","article-title":"Evaluation of pharmacological interactions after administration of a levamisole, albendazole and ivermectin triple combination in lambs","volume":"201","author":"Suarez","year":"2014","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib163","series-title":"Proceedings of the XIII Congresso Brasileiro de Parasitologia Veterinaria, Gramado, Brasil","article-title":"Testing the combination of albendazole, ivermectin and levamisole in lambs parasitized with multiple-resistant gastrointestinal nematodes","author":"Suarez","year":"2014"},{"key":"10.1016\/bs.apar.2016.02.014_bib164","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.pt.2010.11.008","article-title":"Anthelmintic resistance in nematode parasites of cattle: a global issue?","volume":"27","author":"Sutherland","year":"2011","journal-title":"Trends Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib165","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0169-4758(93)90162-9","article-title":"Mechanistic approaches to quantitate anthelmintic absorption by gastrointestinal nematodes","volume":"9","author":"Thompson","year":"1993","journal-title":"Parasitol. Today"},{"key":"10.1016\/bs.apar.2016.02.014_bib166","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1124\/dmd.32.5.536","article-title":"Comparative hepatic and extrahepatic enantioselective sulfoxidation of albendazole and fenbendazole in sheep and cattle","volume":"32","author":"Virkel","year":"2004","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/bs.apar.2016.02.014_bib167","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.vetpar.2013.03.018","article-title":"Biotransformation of albendazole and activities of selected detoxification enzymes in Haemonchus contortus strains susceptible and resistant to anthelmintics","volume":"196","author":"Vok\u0159\u00e1l","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.014_bib168","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1017\/S0031182012001680","article-title":"The metabolic fate of ivermectin in host (Ovis aries) and parasite (Haemonchus contortus)","volume":"140","author":"Vok\u0159\u00e1l","year":"2013","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2016.02.014_bib169","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0166-6851(97)00215-6","article-title":"Ivermectin resistance in nematodes may be caused by alteration of P-glycoprotein homolog","volume":"91","author":"Xu","year":"1998","journal-title":"Mol. Biochem. Parasitol."}],"container-title":["Advances in Parasitology","Haemonchus contortus and Haemonchosis \u2013 Past, Present and Future Trends"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065308X16300148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065308X16300148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T20:02:08Z","timestamp":1758744128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065308X16300148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9780128103951"],"references-count":167,"URL":"https:\/\/doi.org\/10.1016\/bs.apar.2016.02.014","relation":{},"ISSN":["0065-308X"],"issn-type":[{"value":"0065-308X","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}