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Dis."},{"key":"10.1016\/bs.apar.2016.02.015_bib117","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/00480169.2007.36764","article-title":"Resistance to macrocyclic lactone anthelmintics and associated risk factors on sheep farms in the lower North Island of New Zealand","volume":"55","author":"Hughes","year":"2007","journal-title":"N. Z. Vet. J."},{"key":"10.1016\/bs.apar.2016.02.015_bib118","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.ijpara.2007.11.001","article-title":"Genetic and phenotypic differences between isolates of Haemonchus contortus in Australia","volume":"38","author":"Hunt","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.015_bib119","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/B978-0-12-394620-1.00003-5","article-title":"Fluorescent protein methods: strategies and applications","volume":"107","author":"Hutter","year":"2012","journal-title":"Methods Cell. 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J."},{"key":"10.1016\/bs.apar.2016.02.015_bib130","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1001\/jama.299.16.1937","article-title":"Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis","volume":"299","author":"Keiser","year":"2008","journal-title":"JAMA"},{"key":"10.1016\/bs.apar.2016.02.015_bib131","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1038\/ng.2763","article-title":"Dampening of expression oscillations by synchronous regulation of a microRNA and its target","volume":"45","author":"Kim","year":"2013","journal-title":"Nat. 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Parasitol."},{"key":"10.1016\/bs.apar.2016.02.015_bib137","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1046\/j.1365-3024.1999.00220.x","article-title":"Immunization with an affinity purified protein extract from the adult parasite protects lambs against infection with Haemonchus contortus","volume":"21","author":"Knox","year":"1999","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2016.02.015_bib138","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-3024.2005.00750.x","article-title":"Protection induced by vaccinating sheep with a thiol-binding extract of Haemonchus contortus membranes is associated with its protease components","volume":"27","author":"Knox","year":"2005","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2016.02.015_bib139","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2013.09.006","article-title":"The next-generation sequencing revolution and its impact on genomics","volume":"155","author":"Koboldt","year":"2013","journal-title":"Cell"},{"key":"10.1016\/bs.apar.2016.02.015_bib140","doi-asserted-by":"crossref","first-page":"5048","DOI":"10.1098\/rspb.2012.1108","article-title":"Gene duplication as a mechanism of genomic adaptation to a changing environment","volume":"279","author":"Kondrashov","year":"2012","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/bs.apar.2016.02.015_bib141","series-title":"Haemonchus contortus and Haemonchosis Past, Present and Future Trends. vol. 93","first-page":"397","article-title":"Anthelmintic resistance in Haemonchus contortus: history, mechanisms and diagnosis","author":"Kotze","year":"2016"},{"key":"10.1016\/bs.apar.2016.02.015_bib142","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ijpddr.2014.07.007","article-title":"Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug\/receptor interactions","volume":"4","author":"Kotze","year":"2014","journal-title":"Int. J. Parasitol. 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Sci."},{"key":"10.1016\/bs.apar.2016.02.015_bib145","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.actatropica.2011.05.008","article-title":"Cloning, expression, purification and kinetics of trehalose-6-phosphate phosphatase of filarial parasite Brugia malayi","volume":"119","author":"Kushwaha","year":"2011","journal-title":"Acta Trop."},{"key":"10.1016\/bs.apar.2016.02.015_bib146","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1006\/bbrc.1993.1233","article-title":"Effect of selection for benzimidazole resistance in Haemonchus contortus on \u03b2-tubulin isotype 1 and isotype 2 genes","volume":"191","author":"Kwa","year":"1993","journal-title":"Biochem. Biophys. Res. 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Sci."},{"key":"10.1016\/bs.apar.2016.02.015_bib278","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0020-7519(93)90150-W","article-title":"Purification and evaluation of the integral membrane protein H11 as a protective antigen against Haemonchus contortus","volume":"23","author":"Smith","year":"1993","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2016.02.015_bib279","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1046\/j.1365-3024.2003.00637.x","article-title":"Metalloendopeptidases from the intestinal brush border of Haemonchus contortus as protective antigens for sheep","volume":"25","author":"Smith","year":"2003","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2016.02.015_bib280","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-3024.1994.tb00345.x","article-title":"Protection studies with integral membrane fractions of Haemonchus contortus","volume":"16","author":"Smith","year":"1994","journal-title":"Parasitol. 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