{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:30:39Z","timestamp":1783002639730,"version":"3.54.5"},"reference-count":103,"publisher":"Elsevier","isbn-type":[{"value":"9780128151914","type":"print"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1016\/bs.apar.2018.06.002","type":"book-chapter","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T19:38:17Z","timestamp":1532029097000},"page":"45-72","source":"Crossref","is-referenced-by-count":39,"title":["Opisthorchis viverrini Proteome and Host\u2013Parasite Interactions"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.apar.2018.06.002_bib1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.semcancer.2006.03.005","article-title":"14-3-3 proteins: a historic overview","volume":"16","author":"Aitken","year":"2006","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/bs.apar.2018.06.002_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1574-6968.2004.tb09508.x","article-title":"Characterization of an excreted\/secreted antigen form of 14-3-3 protein in Toxoplasma gondii tachyzoites","volume":"234","author":"Assossou","year":"2004","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/bs.apar.2018.06.002_bib3","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1021\/acs.jmedchem.7b00047","article-title":"Development of a potent wound\u00a0healing agent based on the liver fluke granulin structural fold","volume":"60","author":"Bansal","year":"2017","journal-title":"J. Med. Chem."},{"key":"10.1016\/bs.apar.2018.06.002_bib4","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/bies.200900086","article-title":"The granulin gene family: from cancer to dementia","volume":"31","author":"Bateman","year":"2009","journal-title":"Bioessays"},{"key":"10.1016\/bs.apar.2018.06.002_bib5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/WOX.0b013e3182439613","article-title":"Oxidative stress and antioxidant defense","volume":"5","author":"Birben","year":"2012","journal-title":"World Allergy Organ. J."},{"key":"10.1016\/bs.apar.2018.06.002_bib6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1645\/0022-3395(2001)087[0237:GAIOTS]2.0.CO;2","article-title":"Gut-associated immunolocalization of the Schistosoma mansoni cysteine proteases, SmCL1 and SmCL2","volume":"87","author":"Bogitsh","year":"2001","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1177\/2211068213495204","article-title":"Automated image analysis of in vitro angiogenesis assay","volume":"18","author":"Boizeau","year":"2013","journal-title":"J. Lab. Autom."},{"key":"10.1016\/bs.apar.2018.06.002_bib8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0166-6851(00)00351-0","article-title":"Proteolysis of human hemoglobin by schistosome cathepsin D","volume":"112","author":"Brindley","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib9","doi-asserted-by":"crossref","first-page":"e1006393","DOI":"10.1371\/journal.ppat.1006393","article-title":"Helminth infection-induced malignancy","volume":"13","author":"Brindley","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/bs.apar.2018.06.002_bib10","doi-asserted-by":"crossref","first-page":"14342","DOI":"10.1038\/s41598-017-13527-5","article-title":"Suppression of mRNAs encoding CD63 family tetraspanins from the carcinogenic liver fluke Opisthorchis viverrini results in distinct tegument phenotypes","volume":"7","author":"Chaiyadet","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.apar.2018.06.002_bib11","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.ijpara.2015.06.001","article-title":"Excretory\/secretory products of the carcinogenic liver fluke are endocytosed by human cholangiocytes and drive cell proliferation and IL6 production","volume":"45","author":"Chaiyadet","year":"2015","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib12","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.parint.2016.02.001","article-title":"Proteomic characterization of the internalization of Opisthorchis viverrini excretory\/secretory products in human cells","volume":"66","author":"Chaiyadet","year":"2017","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2018.06.002_bib13","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1093\/infdis\/jiv291","article-title":"Carcinogenic liver fluke secretes extracellular vesicles that promote cholangiocytes to adopt a tumorigenic phenotype","volume":"212","author":"Chaiyadet","year":"2015","journal-title":"J. Infect. Dis."},{"key":"10.1016\/bs.apar.2018.06.002_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-cellbio-092910-154002","article-title":"Developmental and pathological angiogenesis","volume":"27","author":"Chung","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/bs.apar.2018.06.002_bib15","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrc2868","article-title":"Targeting the tumour vasculature: insights from physiological angiogenesis","volume":"10","author":"Chung","year":"2010","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/bs.apar.2018.06.002_bib16","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1387\/ijdb.103215ac","article-title":"A brief history of angiogenesis assays","volume":"55","author":"Cimpean","year":"2011","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/bs.apar.2018.06.002_bib17","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1074\/mcp.M115.053934","article-title":"The extracellular vesicles of the helminth pathogen, Fasciola hepatica: biogenesis pathways and cargo molecules involved in parasite pathogenesis","volume":"14","author":"Cwiklinski","year":"2015","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/bs.apar.2018.06.002_bib18","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0020-7519(03)00171-1","article-title":"Fasciola hepatica cathepsin L-like proteases: biology, function, and potential in the development of first generation liver fluke vaccines","volume":"33","author":"Dalton","year":"2003","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/pep2.24062","article-title":"Folding of granulin domains","author":"Dastpeymanm","year":"2018","journal-title":"Peptide Sci."},{"key":"10.1016\/bs.apar.2018.06.002_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/bbrc.1995.2737","article-title":"Characterization and cloning of the cathepsin L proteinases of Schistosoma japonicum","volume":"217","author":"Day","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/bs.apar.2018.06.002_bib21","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s12031-011-9553-z","article-title":"Cellular effects of progranulin in health and disease","volume":"45","author":"De Muynck","year":"2011","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/bs.apar.2018.06.002_bib22","doi-asserted-by":"crossref","first-page":"39316","DOI":"10.1074\/jbc.M607128200","article-title":"A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite","volume":"281","author":"Delcroix","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2018.06.002_bib23","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1017\/S0031182010001642","article-title":"Angiogenesis and parasitic helminth-associated neovascularization","volume":"138","author":"Dennis","year":"2011","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2018.06.002_bib24","doi-asserted-by":"crossref","first-page":"964350","DOI":"10.1155\/2014\/964350","article-title":"Harnessing the helminth secretome for therapeutic immunomodulators","volume":"2014","author":"Ditgen","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/bs.apar.2018.06.002_bib25","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1074\/jbc.M109.060368","article-title":"Helminth cysteine proteases inhibit TRIF-dependent activation of macrophages via degradation of TLR3","volume":"285","author":"Donnelly","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2018.06.002_bib26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1093\/infdis\/jiv356","article-title":"Antibody signatures reflect different disease pathologies in\u00a0patients with schistosomiasis due to Schistosoma japonicum","volume":"213","author":"Driguez","year":"2016","journal-title":"J. Infect. Dis."},{"key":"10.1016\/bs.apar.2018.06.002_bib27","doi-asserted-by":"crossref","first-page":"6622","DOI":"10.1158\/0008-5472.CAN-05-4609","article-title":"Chronic bile duct injury associated with fibrotic matrix microenvironment provokes cholangiocarcinoma in p53-deficient mice","volume":"66","author":"Farazi","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/bs.apar.2018.06.002_bib28","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.semcdb.2011.08.009","article-title":"14-3-3 Proteins: diverse functions in cell proliferation and cancer progression","volume":"22","author":"Freeman","year":"2011","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/bs.apar.2018.06.002_bib29","doi-asserted-by":"crossref","first-page":"e1004033","DOI":"10.1371\/journal.ppat.1004033","article-title":"An immunomics approach to schistosome antigen discovery: antibody signatures of naturally resistant and chronically infected individuals from endemic areas","volume":"10","author":"Gaze","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/bs.apar.2018.06.002_bib30","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrm1661","article-title":"Annexins: linking Ca2+ signalling to membrane dynamics","volume":"6","author":"Gerke","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/bs.apar.2018.06.002_bib31","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S1074-5521(03)00174-1","article-title":"Metal and redox modulation of cysteine protein function","volume":"10","author":"Giles","year":"2003","journal-title":"Chem. Biol."},{"key":"10.1016\/bs.apar.2018.06.002_bib32","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1096\/fj.02-0239fje","article-title":"Aberrant inflammation and resistance to glucocorticoids in annexin 1-\/- mouse","volume":"17","author":"Hannon","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/bs.apar.2018.06.002_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2018.00030","article-title":"Granulin secreted by the food-borne liver fluke Opisthorchis viverrini promotes angiogenesis in human endothelial cells","volume":"5","author":"Haugen","year":"2018","journal-title":"Front. Med."},{"key":"10.1016\/bs.apar.2018.06.002_bib34","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nm816","article-title":"Progranulin is a mediator of the wound response","volume":"9","author":"He","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/bs.apar.2018.06.002_bib35","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1002\/hep.22191","article-title":"Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma","volume":"47","author":"Ho","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/bs.apar.2018.06.002_bib36","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1042\/BST0331375","article-title":"Thiol redox control via thioredoxin and glutaredoxin systems","volume":"33","author":"Holmgren","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/bs.apar.2018.06.002_bib37","article-title":"Conotoxin phi-MiXXVIIA from the superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity","author":"Jin","year":"2017","journal-title":"Angew Chem. Int. Ed. Engl."},{"key":"10.1016\/bs.apar.2018.06.002_bib38","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.exppara.2004.06.006","article-title":"Onchocerca volvulus: expression and immunolocalization of a nematode cathepsin D-like lysosomal aspartic protease","volume":"107","author":"Jolodar","year":"2004","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib39","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00436-007-0831-1","article-title":"Characterization of cysteine proteases from the carcinogenic liver fluke, Opisthorchis viverrini","volume":"102","author":"Kaewpitoon","year":"2008","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2018.06.002_bib40","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.parint.2016.10.021","article-title":"Identification and characterization of protein 14-3-3 in carcinogenic liver fluke Opisthorchis viverrini","volume":"66","author":"Kafle","year":"2017","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2018.06.002_bib41","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nrn.2017.36","article-title":"Progranulin, lysosomal regulation and neurodegenerative disease","volume":"18","author":"Kao","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/bs.apar.2018.06.002_bib42","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/1471-2164-8-189","article-title":"Gene discovery for the carcinogenic human liver fluke, Opisthorchis viverrini","volume":"8","author":"Laha","year":"2007","journal-title":"BMC Genomics"},{"key":"10.1016\/bs.apar.2018.06.002_bib43","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/j.ijid.2008.03.033","article-title":"Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis","volume":"12","author":"Laha","year":"2008","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/bs.apar.2018.06.002_bib44","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0166-6851(97)00074-1","article-title":"Molecular cloning and characterisation of a putative aspartate proteinase associated with a gut membrane protein complex from adult Haemonchus contortus","volume":"88","author":"Longbottom","year":"1997","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib45","doi-asserted-by":"crossref","first-page":"e369","DOI":"10.1371\/journal.pntd.0000369","article-title":"The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease","volume":"3","author":"Lowther","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/bs.apar.2018.06.002_bib46","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.freeradbiomed.2013.07.036","article-title":"The thioredoxin antioxidant system","volume":"66","author":"Lu","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/bs.apar.2018.06.002_bib47","doi-asserted-by":"crossref","first-page":"37789","DOI":"10.1038\/srep37789","article-title":"A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis","volume":"6","author":"Lund","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.apar.2018.06.002_bib48","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0960-9822(01)00052-5","article-title":"Large-scale analysis of gene\u00a0function in Caenorhabditis elegans by high-throughput RNAi","volume":"11","author":"Maeda","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/bs.apar.2018.06.002_bib49","doi-asserted-by":"crossref","first-page":"25040","DOI":"10.3402\/jev.v3.25040","article-title":"Extracellular vesicles in parasitic diseases","volume":"3","author":"Marcilla","year":"2014","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/bs.apar.2018.06.002_bib50","doi-asserted-by":"crossref","first-page":"e45974","DOI":"10.1371\/journal.pone.0045974","article-title":"Extracellular vesicles from parasitic helminths contain specific excretory\/secretory proteins and are internalized in intestinal host cells","volume":"7","author":"Marcilla","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/bs.apar.2018.06.002_bib51","doi-asserted-by":"crossref","first-page":"8667","DOI":"10.1074\/jbc.M116.771675","article-title":"Delineating distinct heme-scavenging and -binding functions of domains in MF6p\/helminth defense molecule (HDM) proteins from parasitic flatworms","volume":"292","author":"Mart\u00ednez-Sern\u00e1ndez","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2018.06.002_bib52","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.biocel.2015.05.014","article-title":"Apoptosis of cholangiocytes modulated by thioredoxin of carcinogenic liver fluke","volume":"65","author":"Matchimakul","year":"2015","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/bs.apar.2018.06.002_bib53","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.ijpara.2012.11.011","article-title":"Immunomodulation by helminth parasites: defining mechanisms and mediators","volume":"43","author":"McSorley","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib54","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.micinf.2011.11.012","article-title":"Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective","volume":"14","author":"McVeigh","year":"2012","journal-title":"Microbes Infect."},{"key":"10.1016\/bs.apar.2018.06.002_bib55","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/14760584.2018.1431125","article-title":"Extracellular vesicles from parasitic helminths and their potential utility as vaccines","volume":"17","author":"Mekonnen","year":"2018","journal-title":"Expert Rev. Vaccines"},{"key":"10.1016\/bs.apar.2018.06.002_bib56","doi-asserted-by":"crossref","first-page":"2988","DOI":"10.1016\/j.vaccine.2016.03.079","article-title":"Advancing a vaccine to prevent human schistosomiasis","volume":"34","author":"Merrifield","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2018.06.002_bib57","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/978-1-60327-530-9_15","article-title":"Inflammation and tumor progression: a lesson from TNF-alpha-dependent FAK signaling in cholangiocarcinoma","volume":"512","author":"Mon","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/bs.apar.2018.06.002_bib58","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3389\/fimmu.2014.00433","article-title":"The role of extracellular vesicles in modulating the host immune response during parasitic infections","volume":"5","author":"Montaner","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.apar.2018.06.002_bib59","doi-asserted-by":"crossref","first-page":"763","DOI":"10.2174\/0929867013372904","article-title":"Thiols in cellular redox signalling and control","volume":"8","author":"Moran","year":"2001","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/bs.apar.2018.06.002_bib60","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1002\/pmic.200900393","article-title":"The secreted and surface proteomes of the adult stage of the carcinogenic human liver fluke Opisthorchis viverrini","volume":"10","author":"Mulvenna","year":"2010","journal-title":"Proteomics"},{"key":"10.1016\/bs.apar.2018.06.002_bib61","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.canlet.2005.04.028","article-title":"Thioredoxin reductase as a novel molecular target for cancer therapy","volume":"236","author":"Nguyen","year":"2006","journal-title":"Cancer Lett."},{"key":"10.1016\/bs.apar.2018.06.002_bib62","doi-asserted-by":"crossref","first-page":"28665","DOI":"10.3402\/jev.v4.28665","article-title":"Protein and small non-coding RNA-enriched extracellular vesicles are released by the pathogenic blood fluke Schistosoma mansoni","volume":"4","author":"Nowacki","year":"2015","journal-title":"J. Extracell. Vesicles"},{"issue":"Suppl. 1","key":"10.1016\/bs.apar.2018.06.002_bib63","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.33549\/physiolres.932659","article-title":"Mechanisms of the 14-3-3 protein function: regulation of protein function through conformational modulation","volume":"63","author":"Obsilova","year":"2014","journal-title":"Physiol. Res."},{"key":"10.1016\/bs.apar.2018.06.002_bib64","doi-asserted-by":"crossref","first-page":"e1005479","DOI":"10.1371\/journal.ppat.1005479","article-title":"Modulation of host angiogenesis as a microbial survival strategy and therapeutic target","volume":"12","author":"Osherov","year":"2016","journal-title":"PLoS Pathog."},{"key":"10.1016\/bs.apar.2018.06.002_bib65","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.exppara.2014.11.004","article-title":"Suppression of Ov-grn-1 encoding granulin of Opisthorchis viverrini inhibits proliferation of biliary epithelial cells","volume":"148","author":"Papatpremsiri","year":"2015","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib66","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.2174\/138161207782360537","article-title":"Thioredoxin and thioredoxin reductase as redox-sensitive molecular targets for cancer therapy","volume":"13","author":"Pennington","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/bs.apar.2018.06.002_bib67","doi-asserted-by":"crossref","first-page":"e398","DOI":"10.1371\/journal.pntd.0000398","article-title":"Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini","volume":"3","author":"Pinlaor","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/bs.apar.2018.06.002_bib68","doi-asserted-by":"crossref","first-page":"e1939","DOI":"10.1371\/journal.pntd.0001939","article-title":"Molecular characterization of a tetraspanin from the human liver fluke, Opisthorchis viverrini","volume":"6","author":"Piratae","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/bs.apar.2018.06.002_bib69","doi-asserted-by":"crossref","first-page":"13073","DOI":"10.1016\/S0021-9258(18)42382-4","article-title":"The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth","volume":"267","author":"Plowman","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2018.06.002_bib70","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.tibs.2008.09.001","article-title":"Helminth pathogen cathepsin proteases: it's a family affair","volume":"33","author":"Robinson","year":"2008","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/bs.apar.2018.06.002_bib71","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/pim.12192","article-title":"Identifying the immunomodulatory components of helminths","volume":"37","author":"Shepherd","year":"2015","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2018.06.002_bib72","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0166-6851(94)90091-4","article-title":"Adult Schistosoma mansoni express cathepsin L proteinase activity","volume":"67","author":"Smith","year":"1994","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib73","doi-asserted-by":"crossref","first-page":"e1000611","DOI":"10.1371\/journal.ppat.1000611","article-title":"A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells","volume":"5","author":"Smout","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/bs.apar.2018.06.002_bib74","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.pep.2011.06.018","article-title":"Expression, refolding and purification of Ov-GRN-1, a granulin-like growth factor from the carcinogenic liver fluke, that causes proliferation of mammalian host cells","volume":"79","author":"Smout","year":"2011","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/bs.apar.2018.06.002_bib75","doi-asserted-by":"crossref","first-page":"e1005209","DOI":"10.1371\/journal.ppat.1005209","article-title":"Carcinogenic parasite secretes growth factor that accelerates wound healing and potentially promotes neoplasia","volume":"11","author":"Smout","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/bs.apar.2018.06.002_bib76","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1039\/c0mb00295j","article-title":"Infection with the carcinogenic human liver fluke, Opisthorchis viverrini","volume":"7","author":"Smout","year":"2011","journal-title":"Mol. Biosyst."},{"key":"10.1016\/bs.apar.2018.06.002_bib77","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1039\/c0mb00295j","article-title":"Infection with the carcinogenic human liver fluke, Opisthorchis viverrini","volume":"7","author":"Smout","year":"2011","journal-title":"Mol. Biosyst."},{"key":"10.1016\/bs.apar.2018.06.002_bib78","doi-asserted-by":"crossref","first-page":"e1000611","DOI":"10.1371\/journal.ppat.1000611","article-title":"A granulin-like growth factor secreted by the carcinogenic liver fluke, Opisthorchis viverrini, promotes proliferation of host cells","volume":"5","author":"Smout","year":"2009","journal-title":"PLoS Pathogens"},{"key":"10.1016\/bs.apar.2018.06.002_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpara.2015.09.002","article-title":"Extracellular vesicles secreted by Schistosoma mansoni contain protein vaccine candidates","volume":"46","author":"Sotillo","year":"2016","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib80","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.actatropica.2003.08.002","article-title":"Pathobiology of opisthorchiasis: an update","volume":"88","author":"Sripa","year":"2003","journal-title":"Acta Trop."},{"key":"10.1016\/bs.apar.2018.06.002_bib81","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.pt.2012.07.006","article-title":"The tumorigenic liver fluke Opisthorchis viverrini\u2013multiple pathways to cancer","volume":"28","author":"Sripa","year":"2012","journal-title":"Trends Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib82","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S0020-7519(00)00054-0","article-title":"Localisation of parasite antigens and inflammatory responses in experimental opisthorchiasis","volume":"30","author":"Sripa","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib83","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1371\/journal.pmed.0040201","article-title":"Liver fluke induces cholangiocarcinoma","volume":"4","author":"Sripa","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/bs.apar.2018.06.002_bib84","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1371\/journal.pmed.0040201","article-title":"Liver fluke induces cholangiocarcinoma","volume":"4","author":"Sripa","year":"2007","journal-title":"PLoS Medicine"},{"key":"10.1016\/bs.apar.2018.06.002_bib85","doi-asserted-by":"crossref","first-page":"e1654","DOI":"10.1371\/journal.pntd.0001654","article-title":"Elevated plasma IL-6 associates with increased risk of advanced fibrosis and cholangiocarcinoma in individuals infected by Opisthorchis viverrini","volume":"6","author":"Sripa","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/bs.apar.2018.06.002_bib86","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.1462-5822.2010.01433.x","article-title":"Secreted cysteine proteases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans-processing by cathepsin B","volume":"12","author":"Sripa","year":"2010","journal-title":"Cell Microbiol."},{"key":"10.1016\/bs.apar.2018.06.002_bib87","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.parint.2011.04.003","article-title":"RNA interference targeting cathepsin B of the carcinogenic liver fluke, Opisthorchis viverrini","volume":"60","author":"Sripa","year":"2011","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2018.06.002_bib88","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.molbiopara.2008.04.010","article-title":"Characterization of the antioxidant enzyme, thioredoxin peroxidase, from the carcinogenic human liver fluke, Opisthorchis viverrini","volume":"160","author":"Suttiprapa","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib89","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.parint.2011.06.018","article-title":"Molecular expression and enzymatic characterization of thioredoxin from the carcinogenic human liver fluke Opisthorchis viverrini","volume":"61","author":"Suttiprapa","year":"2012","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2018.06.002_bib90","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.biocel.2008.10.013","article-title":"Ov-APR-1, an aspartic protease from the carcinogenic liver fluke, Opisthorchis viverrini: functional expression, immunolocalization and subsite specificity","volume":"41","author":"Suttiprapa","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/bs.apar.2018.06.002_bib91","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1021\/pr5010136","article-title":"Characterization of 14-3-3 isoforms expressed in the Echinococcus granulosus pathogenic larval stage","volume":"14","author":"Teichmann","year":"2015","journal-title":"J. Proteome Res."},{"key":"10.1016\/bs.apar.2018.06.002_bib92","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1110\/ps.073295308","article-title":"Structure dissection of human progranulin identifies well-folded granulin\/epithelin modules with unique functional activities","volume":"17","author":"Tolkatchev","year":"2008","journal-title":"Protein Sci."},{"key":"10.1016\/bs.apar.2018.06.002_bib93","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1038\/nm1430","article-title":"Tetraspanins on the surface of\u00a0Schistosoma mansoni are protective antigens against schistosomiasis","volume":"12","author":"Tran","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/bs.apar.2018.06.002_bib94","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.parint.2016.05.013","article-title":"Unusual thiol-based redox metabolism of parasitic flukes","volume":"66","author":"Tripathi","year":"2017","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2018.06.002_bib95","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1096\/fj.02-0181fje","article-title":"Cleavage of hemoglobin by hookworm cathepsin D aspartic proteases and its potential contribution to host specificity","volume":"16","author":"Williamson","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/bs.apar.2018.06.002_bib96","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1471-4922(03)00189-2","article-title":"Digestive proteases of blood-feeding nematodes","volume":"19","author":"Williamson","year":"2003","journal-title":"Trends Parasitol."},{"key":"10.1016\/bs.apar.2018.06.002_bib97","doi-asserted-by":"crossref","first-page":"35950","DOI":"10.1074\/jbc.M405842200","article-title":"A multi-enzyme cascade of hemoglobin proteolysis in the intestine of blood-feeding hookworms","volume":"279","author":"Williamson","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2018.06.002_bib98","doi-asserted-by":"crossref","first-page":"87","DOI":"10.4269\/ajtmh.2004.71.87","article-title":"Cloning and characterization of a new cysteine proteinase secreted by Paragonimus westermani adult worms","volume":"71","author":"Yang","year":"2004","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/bs.apar.2018.06.002_bib99","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/path.2472","article-title":"Matrix proteins of basement membrane of intrahepatic bile ducts\u00a0are degraded in congenital hepatic fibrosis and Caroli's disease","volume":"217","author":"Yasoshima","year":"2009","journal-title":"J. Pathol."},{"key":"10.1016\/bs.apar.2018.06.002_bib100","doi-asserted-by":"crossref","first-page":"e719","DOI":"10.1371\/journal.pntd.0000719","article-title":"Unlocking the transcriptomes of two carcinogenic parasites, Clonorchis sinensis and Opisthorchis viverrini","volume":"4","author":"Young","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/bs.apar.2018.06.002_bib101","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms5378","article-title":"The Opisthorchis viverrini genome provides insights into life in the bile duct","volume":"5","author":"Young","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/bs.apar.2018.06.002_bib102","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1038\/ncomms5378","article-title":"The Opisthorchis viverrini genome provides insights into life in the bile duct","volume":"5","author":"Young","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/bs.apar.2018.06.002_bib103","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1128\/CDLI.7.6.932-939.2000","article-title":"Structural and immunological characteristics of a 28-kilodalton cruzipain-like cysteine protease of Paragonimus westermani expressed in the definitive host stage","volume":"7","author":"Yun","year":"2000","journal-title":"Clin. Diagn. Lab. Immunol."}],"container-title":["Advances in Parasitology","Asiatic Liver Fluke - From Basic Science to Public Health, Part B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065308X18300502?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065308X18300502?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T20:03:47Z","timestamp":1758744227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065308X18300502"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9780128151914"],"references-count":103,"URL":"https:\/\/doi.org\/10.1016\/bs.apar.2018.06.002","relation":{},"ISSN":["0065-308X"],"issn-type":[{"value":"0065-308X","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]}}}