{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T03:58:03Z","timestamp":1791518283111,"version":"4.3.4"},"reference-count":95,"publisher":"Elsevier","isbn-type":[{"value":"9780081027509","type":"print"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/bs.apar.2018.08.002","type":"book-chapter","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T20:29:11Z","timestamp":1536352151000},"page":"91-115","source":"Crossref","is-referenced-by-count":80,"title":["Drug Combinations Against Soil-Transmitted Helminth Infections"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.apar.2018.08.002_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1515\/acve-2017-0013","article-title":"A brief review on the mode of action of antinematodal drugs:","volume":"67","author":"Abongwa","year":"2017","journal-title":"Acta Vet. (Beogr.)"},{"key":"10.1016\/bs.apar.2018.08.002_bib2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0035-9203(02)90352-4","article-title":"Evaluation of the efficacy of pyrantel-oxantel for the treatment of soil-transmitted nematode infections","volume":"96","author":"Albonico","year":"2002","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/bs.apar.2018.08.002_bib3","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/S1473-3099(18)30233-0","article-title":"Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine, and oxantel pamoate-albendazole against Trichuris trichiura infections: a randomized, non-inferiority, single blind trial","volume":"18","author":"Barda","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/cid\/cix278","article-title":"Efficacy of moxidectin versus\u00a0ivermectin against Strongyloides stercoralis infections: a randomized controlled non-inferiority trial","volume":"65","author":"Barda","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib5","doi-asserted-by":"crossref","first-page":"479","DOI":"10.4269\/ajtmh.1999.60.479","article-title":"Assessment of combined ivermectin and albendazole for treatment of intestinal helminth and Wuchereria bancrofti infections in Haitian schoolchildren","volume":"60","author":"Beach","year":"1999","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/bs.apar.2018.08.002_bib6","first-page":"35","article-title":"A comparison of the efficacy of single doses of albendazole, ivermectin, and diethylcarbamazine alone or in combinations against Ascaris and Trichuris\u00a0spp","volume":"81","author":"Belizario","year":"2003","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/bs.apar.2018.08.002_bib7","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.2460\/ajvr.1988.49.11.1986","article-title":"Effects of milbemycin on adult Toxocara canis in dogs with experimentally induced infection","volume":"49","author":"Bowman","year":"1988","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/bs.apar.2018.08.002_bib8","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/S1473-3099(18)30268-8","article-title":"Soil-transmitted helminth treatment: multiple-drug regimens","volume":"18","author":"Brooker","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib9","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.ijpddr.2014.06.002","article-title":"Resistance to the macrocyclic lactone moxidectin is mediated in part by membrane transporter P-glycoproteins: implications for control of drug resistant parasitic nematodes","volume":"4","author":"Bygarski","year":"2014","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/bs.apar.2018.08.002_bib10","first-page":"95","article-title":"Clinical trial of oxantel-pyrantel (Quantrel) against trichuriasis","volume":"16","author":"Cabrera","year":"1980","journal-title":"Acta Med. Philipp."},{"key":"10.1016\/bs.apar.2018.08.002_bib11","first-page":"502","article-title":"Clinical trials of broad spectrum anthelmintics against soil-transmitted helminthiasis","volume":"11","author":"Cabrera","year":"1980","journal-title":"Southeast Asian J. Trop. Med. Publ. Health"},{"key":"10.1016\/bs.apar.2018.08.002_bib12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1146\/annurev.mi.45.100191.002305","article-title":"Ivermectin as an antiparasitic agent for use in humans","volume":"45","author":"Campbell","year":"1991","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/bs.apar.2018.08.002_bib13","first-page":"184","article-title":"Clinical observation of the efficacy of tribendimidine against hookworm infections","volume":"13","author":"Cao","year":"2000","journal-title":"Chin. J. Parasit. Dis. Control"},{"key":"10.1016\/bs.apar.2018.08.002_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076654","article-title":"Graphical tools for network meta-analysis in STATA","volume":"8","author":"Chaimani","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/bs.apar.2018.08.002_bib15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3347\/kjp.1979.17.1.60","article-title":"A clinical trial of oxantel and pyrantel against intestinal nematodes infections","volume":"17","author":"Choi","year":"1979","journal-title":"Kor. J. Parasitol."},{"key":"10.1016\/bs.apar.2018.08.002_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.coviro.2016.03.004","article-title":"Current status and prospects of HIV treatment","volume":"18","author":"Cihlar","year":"2016","journal-title":"Curr. Opin. Virol."},{"key":"10.1016\/bs.apar.2018.08.002_bib17","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1756-3305-2-S2-S5","article-title":"Moxidectin: a review of chemistry, pharmacokinetics and use in horses","volume":"2","author":"Cobb","year":"2009","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2018.08.002_bib18","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1177\/0091270003257456","article-title":"The antiparasitic moxidectin: safety, tolerability, and pharmacokinetics in humans","volume":"43","author":"Cotreau","year":"2003","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/bs.apar.2018.08.002_bib19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0304-4017(92)90090-V","article-title":"Efficacy of moxidectin against an ivermectin-resistant strain of Haemonchus contortus in sheep","volume":"41","author":"Craig","year":"1992","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2018.08.002_bib20","series-title":"Preventive chemotherapy in human helminthiasis: Coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers","author":"Crompton","year":"2006"},{"key":"10.1016\/bs.apar.2018.08.002_bib21","doi-asserted-by":"crossref","first-page":"e397","DOI":"10.1371\/journal.pntd.0000397","article-title":"Assays to detect beta-tubulin codon 200 polymorphism in Trichuris trichiura and Ascaris lumbricoides","volume":"3","author":"Diawara","year":"2009","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib22","doi-asserted-by":"crossref","first-page":"e2247","DOI":"10.1371\/journal.pntd.0002247","article-title":"Association between response to albendazole treatment and \u03b2-tubulin genotype frequencies in soil-transmitted helminths","volume":"7","author":"Diawara","year":"2013","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib23","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.4269\/ajtmh.12-0484","article-title":"Molecular and biological diagnostic tests for monitoring benzimidazole resistance in human soil-transmitted\u00a0helminths","volume":"88","author":"Diawara","year":"2013","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/bs.apar.2018.08.002_bib24","article-title":"Study on the efficacy of tribendimidine for treatment of intestinal nematode infections","volume":"02","author":"Fang","year":"2002","journal-title":"Chin. J. Schistosomiasis Control"},{"key":"10.1016\/bs.apar.2018.08.002_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005163","article-title":"Potential value of triple drug therapy with ivermectin, diethylcarbamazine, and albendazole (IDA) to accelerate elimination of lymphatic filariasis and onchocerciasis in Africa","volume":"11","author":"Fischer","year":"2017","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib26","doi-asserted-by":"crossref","first-page":"914","DOI":"10.4269\/ajtmh.1976.25.914","article-title":"Treatment for trichuriasis with oxantel","volume":"25","author":"Garcia","year":"1976","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/bs.apar.2018.08.002_bib27","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/S0140-6736(96)11094-1","article-title":"Serious reactions after mass treatment of onchocerciasis with ivermectin in an area endemic for Loa loa infection","volume":"350","author":"Gardon","year":"1997","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/bs.apar.2018.08.002_bib28","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/S0140-6736(17)32130-X","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016","volume":"390","author":"GBD 2016 DALYs and HALE Collaborators","year":"2017","journal-title":"Lancet Lond. Engl."},{"key":"10.1016\/bs.apar.2018.08.002_bib29","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.pt.2005.08.014","article-title":"Ivermectin 20 years on: maturation of a wonder drug","volume":"21","author":"Geary","year":"2005","journal-title":"Trends Parasitol."},{"key":"10.1016\/bs.apar.2018.08.002_bib30","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1128\/CMR.13.2.207","article-title":"Drug resistance in human helminths: current situation and lessons from livestock","volume":"13","author":"Geerts","year":"2000","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/bs.apar.2018.08.002_bib31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.vetpar.2006.10.003","article-title":"Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutation for benzimidazole resistance in nematodes","volume":"144","author":"Ghisi","year":"2007","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2018.08.002_bib32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0166-6851(96)02793-4","article-title":"Characterization of an acetylcholine receptor gene of Haemonchus contortus in relation to levamisole resistance","volume":"84","author":"Hoekstra","year":"1997","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2018.08.002_bib33","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.pt.2004.08.001","article-title":"Drug resistance in nematodes of veterinary importance: a status report","volume":"20","author":"Kaplan","year":"2004","journal-title":"Trends Parasitol."},{"key":"10.1016\/bs.apar.2018.08.002_bib34","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.vetpar.2011.11.048","article-title":"An inconvenient truth: global worming and anthelmintic resistance","volume":"186","author":"Kaplan","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2018.08.002_bib35","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0065-308X(10)73008-6","article-title":"The drugs we have and the drugs we need against major helminth infections","volume":"73","author":"Keiser","year":"2010","journal-title":"Adv. Parasitol."},{"key":"10.1016\/bs.apar.2018.08.002_bib36","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1001\/jama.299.16.1937","article-title":"Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis","volume":"299","author":"Keiser","year":"2008","journal-title":"JAMA, J. Am. Med. Assoc."},{"key":"10.1016\/bs.apar.2018.08.002_bib37","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.critrevonc.2014.06.002","article-title":"Strategies for the empirical management of infection in\u00a0cancer patients with emphasis on the emergence of resistant gram-negative bacteria","volume":"92","author":"Klastersky","year":"2014","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/bs.apar.2018.08.002_bib38","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1086\/657310","article-title":"Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial","volume":"51","author":"Knopp","year":"2010","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib39","first-page":"3381","article-title":"Pyrantel and oxantel pamoate","volume":"3","author":"Kopp","year":"2017"},{"key":"10.1016\/bs.apar.2018.08.002_bib40","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1177\/2160763X11432508","article-title":"Relative bioavailability of liquid and tablet formulations of the antiparasitic moxidectin","volume":"1","author":"Korth-Bradley","year":"2012","journal-title":"Clin. Pharmacol. Drug Dev."},{"key":"10.1016\/bs.apar.2018.08.002_bib41","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ijpddr.2017.06.001","article-title":"Reduced efficacy of albendazole against Ascaris lumbricoides in Rwandan schoolchildren","volume":"7","author":"Kr\u00fccken","year":"2017","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/bs.apar.2018.08.002_bib42","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.ijpddr.2016.04.002","article-title":"Research for new drugs for elimination of onchocerciasis in Africa","volume":"6","author":"Kuesel","year":"2016","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/bs.apar.2018.08.002_bib43","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0169-4758(90)90227-U","article-title":"Mode of action of benzimidazoles","volume":"6","author":"Lacey","year":"1990","journal-title":"Parasitol. Today"},{"key":"10.1016\/bs.apar.2018.08.002_bib44","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4269\/ajtmh.1976.25.563","article-title":"Therapeutic evaluation of oxantel pamoate (1, 4, 5, 6-tetrahydro-1-methyl-2-[trans-3-hydroxystyryl] pyrimidine pamoate) in severe Trichuris trichiura infection","volume":"25","author":"Lee","year":"1976","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"Suppl 1","key":"10.1016\/bs.apar.2018.08.002_bib45","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2165\/00003495-197800151-00018","article-title":"A comparative study of the effect of oxantel-pyrantel suspension and mebendazole in mixed infections with Ascaris and Trichuris","volume":"15","author":"Lee","year":"1978","journal-title":"Drugs"},{"key":"10.1016\/bs.apar.2018.08.002_bib46","series-title":"Pyrantel Parasiticide Therapy in Humans and Domestic Animals","first-page":"109","article-title":"Pyrantel parasiticide therapy in humans","author":"Levecke","year":"2016"},{"issue":"Suppl 1","key":"10.1016\/bs.apar.2018.08.002_bib47","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2165\/00003495-197800151-00019","article-title":"Anthelminthic effect of oxantel and oxantel-pyrantel in intestinal nematode infections","volume":"15","author":"Lim","year":"1978","journal-title":"Drugs"},{"key":"10.1016\/bs.apar.2018.08.002_bib48","article-title":"A research agenda for helminth diseases of humans: the problem of helminthiases","volume":"6","author":"Lustigman","year":"2012","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib49","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.2174\/138920112800399310","article-title":"Macrocyclic lactones for parasite control in equids","volume":"13","author":"Lyons","year":"2012","journal-title":"Curr. Pharmaceut. Biotechnol."},{"key":"10.1016\/bs.apar.2018.08.002_bib50","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4269\/ajtmh.1996.55.477","article-title":"A comparative trial of a single-dose ivermectin versus three days of albendazole for treatment of Strongyloides stercoralis and other soil-transmitted helminth infections in children","volume":"55","author":"Marti","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/bs.apar.2018.08.002_bib51","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.ijpara.2004.04.014","article-title":"Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris","volume":"34","author":"Martin","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2018.08.002_bib52","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/MOG.0000000000000025","article-title":"Global progress towards eliminating gastrointestinal helminth infections","volume":"30","author":"McCarty","year":"2014","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/bs.apar.2018.08.002_bib53","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1473-3099(15)00271-6","article-title":"Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study","volume":"16","author":"Moser","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib56","doi-asserted-by":"crossref","first-page":"j4307","DOI":"10.1136\/bmj.j4307","article-title":"Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis","volume":"358","author":"Moser","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/bs.apar.2018.08.002_bib54","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/S1473-3099(17)30487-5","volume":"17","author":"Moser","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib55","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/S1473-3099(18)30220-2","volume":"18","author":"Moser","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib57","article-title":"Efficacy of single-dose 500 mg mebendazole in soil-transmitted helminth infections: a review","volume":"1\u201310","author":"Mrus","year":"2017","journal-title":"J. Helminthol."},{"key":"10.1016\/bs.apar.2018.08.002_bib58","doi-asserted-by":"crossref","first-page":"304","DOI":"10.4269\/ajtmh.1989.40.304","article-title":"Ivermectin for human strongyloidiasis and other intestinal helminths","volume":"40","author":"Naquira","year":"1989","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/bs.apar.2018.08.002_bib59","doi-asserted-by":"crossref","first-page":"856","DOI":"10.4269\/ajtmh.2008.79.856","article-title":"Efficacy of ivermectin and albendazole alone and in combination for treatment of soil-transmitted helminths in pregnancy and adverse events: a randomized open label controlled intervention trial in Masindi district, western Uganda","volume":"79","author":"Ndyomugyenyi","year":"2008","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/bs.apar.2018.08.002_bib60","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.2174\/138920112800399167","article-title":"Macrocyclic lactones in the treatment and control of parasitism in small companion animals","volume":"13","author":"Nolan","year":"2012","journal-title":"Curr. Pharmaceut. Biotechnol."},{"key":"10.1016\/bs.apar.2018.08.002_bib61","doi-asserted-by":"crossref","first-page":"e1138","DOI":"10.1371\/journal.pntd.0001138","article-title":"Potential drug development candidates for human soil-transmitted helminthiases","volume":"5","author":"Olliaro","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(17)32844-1","article-title":"Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised, controlled, double-blind phase 3 trial","author":"Opoku","year":"2018","journal-title":"in press. Lancet Lond. Engl."},{"key":"10.1016\/bs.apar.2018.08.002_bib63","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/inf.1982.14.issue-4.10","article-title":"Treatment of Trichuris trichiura infection with a single dose of oxantel pamoate","volume":"14","author":"Peld\u00e1n","year":"1982","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib64","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1756-3305-7-37","article-title":"Global numbers of infection and disease burden of soil transmitted helminth infections in 2010","volume":"7","author":"Pullan","year":"2014","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2018.08.002_bib65","first-page":"2606","article-title":"Pharmacology of N-, L-, and B-subtypes of nematode nAChR resolved at the single-channel level in Ascaris suum","volume":"20","author":"Qian","year":"2006","journal-title":"FASEB J. Off.\u00a0Publ. Fed. Am. Soc. Exp. Biol."},{"key":"10.1016\/bs.apar.2018.08.002_bib66","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1186\/1756-3305-6-314","article-title":"Accuracy of the Kato-Katz method and formalin-ether concentration technique for the diagnosis of Clonorchis sinensis, and implication for assessing drug efficacy","volume":"6","author":"Qian","year":"2013","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2018.08.002_bib67","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3347\/kjp.1981.19.2.95","article-title":"Anthelmintic effects of single doses of fenbendazole and oxantel pyrantel pamoate to the intestinal nematodes","volume":"19","author":"Rim","year":"1981","journal-title":"Kor. J. Parasitol."},{"key":"10.1016\/bs.apar.2018.08.002_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003495","article-title":"Tribendimidine: mode of action and nAChR subtype selectivity in Ascaris and Oesophagostomum","volume":"9","author":"Robertson","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib69","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0014-2999(94)90784-6","article-title":"The action of pyrantel as an agonist and an open channel blocker at acetylcholine receptors in isolated Ascaris suum muscle vesicles","volume":"271","author":"Robertson","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/bs.apar.2018.08.002_bib70","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.bmc.2008.12.003","article-title":"Ivermectin-derived leishmanicidal compounds","volume":"17","author":"Santos","year":"2009","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/bs.apar.2018.08.002_bib71","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S1473-3099(16)30198-0","article-title":"Efficacy and safety of tribendimidine against Opisthorchis viverrini: two randomised, parallel-group, single-blind, dose-ranging, phase 2 trials","volume":"16","author":"Sayasone","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib72","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/00034983.1981.11687445","article-title":"The anthelmintic effects of pyrantel pamoate, oxantel-pyrantel\u00a0pamoate, levamisole and mebendazole in the treatment of intestinal nematodes","volume":"75","author":"Sinniah","year":"1981","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/bs.apar.2018.08.002_bib73","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1080\/00034983.1980.11687395","article-title":"Single dose treatment of intestinal nematodes with oxantel-pyrantel pamoate plus mebendazole","volume":"74","author":"Sinniah","year":"1980","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/bs.apar.2018.08.002_bib74","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S1473-3099(10)70250-4","article-title":"Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, tribendimidine, and praziquantel in patients with Opisthorchis viverrini: a randomised, exploratory, open-label, phase 2 trial","volume":"11","author":"Soukhathammavong","year":"2011","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib75","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S1473-3099(14)71050-3","volume":"15","author":"Speich","year":"2015","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib76","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMoa1301956","article-title":"Oxantel pamoate\u2013albendazole for Trichuris trichiura infection","volume":"370","author":"Speich","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/bs.apar.2018.08.002_bib77","doi-asserted-by":"crossref","first-page":"e322","DOI":"10.1371\/journal.pntd.0000322","article-title":"Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial","volume":"2","author":"Steinmann","year":"2008","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib78","series-title":"London Declaration on Neglected Tropical Diseases","author":"Uniting to Combat NTDs","year":"2012"},{"key":"10.1016\/bs.apar.2018.08.002_bib79","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.ijpddr.2011.09.002","article-title":"Is anthelmintic resistance a concern for the control of human soil-transmitted helminths?","volume":"1","author":"Vercruysse","year":"2011","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/bs.apar.2018.08.002_bib80","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.actatropica.2008.03.007","article-title":"A randomized, double-blind, multicenter clinical trial on the efficacy of ivermectin against intestinal nematode infections in China","volume":"106","author":"Wen","year":"2008","journal-title":"Acta Trop."},{"key":"10.1016\/bs.apar.2018.08.002_bib81","first-page":"589","article-title":"Summary of global update on preventive chemotherapy implementation in 2016: crossing the billion - Wkly Epidemiol Rec","volume":"92","author":"WHO","year":"2017"},{"key":"10.1016\/bs.apar.2018.08.002_bib82","first-page":"1","article-title":"Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups Guideline","author":"WHO","year":"2017","journal-title":"Geneva World Health Organzation"},{"key":"10.1016\/bs.apar.2018.08.002_bib83","series-title":"WHO Model Lists of Essential Medicines - 20th List, Geneva World Health Organization","author":"WHO","year":"2017"},{"key":"10.1016\/bs.apar.2018.08.002_bib84","series-title":"Guideline \u2012 Alternative mass drug administration regimens to eliminate lymphatic filariasis","author":"WHO","year":"2017"},{"key":"10.1016\/bs.apar.2018.08.002_bib85","series-title":"WHO Model List of Essential Medicines - 19th List","author":"WHO","year":"2015"},{"key":"10.1016\/bs.apar.2018.08.002_bib86","series-title":"Assessing the efficacy of anthelminthic drugs against schistosomiasis and soil-transmitted helminthiases","author":"WHO","year":"2013"},{"key":"10.1016\/bs.apar.2018.08.002_bib88","series-title":"Soil-transmitted helminthiasis: eliminating soil-transmitted helminthiasis as a public health problem in children. Progress Report 2001-2010 and Strategic Plan 2011-2020","author":"WHO","year":"2012"},{"key":"10.1016\/bs.apar.2018.08.002_bib89","doi-asserted-by":"crossref","DOI":"10.1093\/cid\/ciy246","article-title":"Efficacy and safety of ivermectin against Trichuris trichiura in preschool- and school-aged children: a randomized controlled dose-finding trial","author":"Wimmersberger","year":"2018","journal-title":"Clin. Infect. Dis. in press"},{"key":"10.1016\/bs.apar.2018.08.002_bib90","series-title":"WHA54.19 Schistosomiasis and Soil-transmitted Helminth Infections","author":"World Health Assembly","year":"2001"},{"key":"10.1016\/bs.apar.2018.08.002_bib91","first-page":"23","article-title":"Effect of a novel drug--enteric coated tribendimidine in the treatment of intestinal nematode infections","volume":"24","author":"Wu","year":"2006","journal-title":"Chinese journal of parasitology & parasitic diseases"},{"key":"10.1016\/bs.apar.2018.08.002_bib92","article-title":"Therapeutic effect of tribendimidine combined with ivermectin against human intestinal nematode infection","volume":"2","author":"Wu","year":"2003","journal-title":"Chinese J Pract. Par. Diseases"},{"key":"10.1016\/bs.apar.2018.08.002_bib93","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2005.01.013","article-title":"Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China","volume":"94","author":"Xiao","year":"2005","journal-title":"Acta Trop."},{"key":"10.1016\/bs.apar.2018.08.002_bib94","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.actatropica.2013.01.009","article-title":"Advances with the Chinese anthelminthic drug tribendimidine in clinical trials and laboratory investigations","volume":"126","author":"Xiao","year":"2013","journal-title":"Acta Trop."},{"key":"10.1016\/bs.apar.2018.08.002_bib95","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003046","article-title":"Efficacy and safety of praziquantel, tribendimidine and mebendazole in patients with co-infection of Clonorchis sinensis and other helminths","volume":"8","author":"Xu","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/bs.apar.2018.08.002_bib96","article-title":"Therapeutic effect of tribendimidine in treatment of Enterobius vermicularis infection","volume":"226","author":"Zhou","year":"2008","journal-title":"Chin. J. Schistosomiasis Control"}],"container-title":["Advances in Parasitology","Highlighting Operational and Implementation Research for Control of Helminthiasis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065308X18300551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065308X18300551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T20:04:12Z","timestamp":1758744252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065308X18300551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9780081027509"],"references-count":95,"URL":"https:\/\/doi.org\/10.1016\/bs.apar.2018.08.002","relation":{},"ISSN":["0065-308X"],"issn-type":[{"value":"0065-308X","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}