{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T11:01:37Z","timestamp":1743073297725,"version":"3.40.3"},"reference-count":564,"publisher":"Elsevier","isbn-type":[{"type":"print","value":"9780443223303"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["RVO 61388963"],"award-info":[{"award-number":["RVO 61388963"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/bs.apar.2024.07.002","type":"book-chapter","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T11:30:49Z","timestamp":1726831849000},"page":"97-176","source":"Crossref","is-referenced-by-count":0,"title":["An update on proteases and protease inhibitors from trematodes"],"prefix":"10.1016","author":[{"given":"Martin","family":"Horn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Bielikov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Vostoupalov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakub","family":"\u0160v\u00e9da","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mare\u0161","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/bs.apar.2024.07.002_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.29252\/vacres.6.2.1","article-title":"Immunogenicity and protective capacity of Schistosoma haematobium recombinant cathepsin L against infection of hamsters with S. haematobium","volume":"6","author":"Abdel Aziz","year":"2019","journal-title":"Vaccine Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0040014","article-title":"Schistosomiasis mansoni: novel chemotherapy using a cysteine protease inhibitor","volume":"4","author":"Abdulla","year":"2007","journal-title":"PLoS Med."},{"key":"10.1016\/bs.apar.2024.07.002_bib3","first-page":"147","article-title":"Localization of leucine aminopeptidase in the Schistosoma mansoni eggs and in liver tissue from infected mice","volume":"35","author":"Abouel-Nour","year":"2005","journal-title":"J. Egypt. Soc. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib4","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.molbiopara.2007.11.011","article-title":"Fasciola hepatica leucine aminopeptidase, a promising candidate for vaccination against ruminant fasciolosis","volume":"158","author":"Acosta","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2307\/3284518","article-title":"Characterization and partial purification of a leucine aminopeptidase from Fasciola hepatica","volume":"84","author":"Acosta","year":"1998","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14081531","article-title":"In vivo evaluation of an antibody-functionalized lipoidal nanosystem for schistosomiasis intervention","volume":"14","author":"Adekiya","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/bs.apar.2024.07.002_bib7","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.molbiopara.2007.07.006","article-title":"Comparative molecular analysis of two asparaginyl endopeptidases and encoding genes from Fasciola gigantica","volume":"156","author":"Adisakwattana","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2478\/s11686-020-00177-3","article-title":"Serodiagnosis of Fasciola gigantica infection in buffaloes with native cathepsin-L proteases and recombinant cathepsin L1-D","volume":"65","author":"Aftab","year":"2020","journal-title":"Acta Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib9","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.bmc.2015.01.033","article-title":"The use of a conformational cathepsin D-derived epitope for vaccine development against Schistosoma mansoni","volume":"23","author":"Ahmad Fuaad","year":"2015","journal-title":"Bioorgan. Med. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib10","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1111\/j.1365-3024.2008.01091.x","article-title":"Sm-p80-based DNA vaccine formulation induces potent protective immunity against Schistosoma mansoni","volume":"31","author":"Ahmad","year":"2009","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib11","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/infdis\/jir545","article-title":"Preclinical prophylactic efficacy testing of Sm-p80-based vaccine in a nonhuman primate model of Schistosoma mansoni infection and immunoglobulin G and E responses to Sm-p80 in human serum samples from an area where schistosomiasis is endemic","volume":"204","author":"Ahmad","year":"2011","journal-title":"J. Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib12","doi-asserted-by":"crossref","first-page":"2830","DOI":"10.1016\/j.vaccine.2009.02.096","article-title":"Protective and antifecundity effects of Sm-p80-based DNA vaccine formulation against Schistosoma mansoni in a nonhuman primate model","volume":"27","author":"Ahmad","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib13","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1007\/s00436-009-1646-z","article-title":"Prime-boost and recombinant protein vaccination strategies using Sm-p80 protects against Schistosoma mansoni infection in the mouse model to levels previously attainable only by the irradiated cercarial vaccine","volume":"105","author":"Ahmad","year":"2009","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib14","doi-asserted-by":"crossref","first-page":"e781","DOI":"10.1016\/j.ijid.2010.02.2266","article-title":"Protective effects of Sm-p80 in the presence of resiquimod as an adjuvant against challenge infection with Schistosoma mansoni in mice","volume":"14","author":"Ahmad","year":"2010","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.parint.2014.09.012","article-title":"Expression characteristics and specific antibody reactivity of diverse cathepsin F members of Paragonimus westermani","volume":"64","author":"Ahn","year":"2015","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib16","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1080\/23144599.2023.2273678","article-title":"Antibody detection against Kunitz-type protein in Fasciola hepatica experimentally infected sheep using enzyme-linked immunosorbent assay (ELISA)","volume":"11","author":"Ahumada","year":"2023","journal-title":"Int. J. Vet. Sci. Med."},{"key":"10.1016\/bs.apar.2024.07.002_bib17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.molimm.2020.05.011","article-title":"Immunomodulatory properties of Schistosoma mansoni proteins Sm200 and SmKI-1 in vitro and in a murine model of allergy to the mite Blomia tropicalis","volume":"124","author":"Alves","year":"2020","journal-title":"Mol. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib18","doi-asserted-by":"crossref","first-page":"15085","DOI":"10.1016\/S0021-9258(18)98590-X","article-title":"Characterization of cDNA clones encoding a novel calcium-activated neutral proteinase from Schistosoma mansoni","volume":"266","author":"Andresen","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib19","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.actatropica.2013.03.020","article-title":"Diagnosis of Fasciola gigantica infection using a monoclonal antibody-based sandwich ELISA for detection of circulating cathepsin B3 protease","volume":"127","author":"Anuracpreeda","year":"2013","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145650","article-title":"Immunodiagnosis of Fasciola gigantica infection using monoclonal antibody-based sandwich ELISA and immunochromatographic assay for detection of circulating cathepsin L1 protease","volume":"11","author":"Anuracpreeda","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/bs.apar.2024.07.002_bib21","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.exppara.2010.08.012","article-title":"Fasciola gigantica: production and characterization of a monoclonal antibody against recombinant cathepsin B3","volume":"127","author":"Anuracpreeda","year":"2011","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2014.04.012","article-title":"Production and characterization of a monoclonal antibody against recombinant cathepsin L1 of Fasciola gigantica","volume":"136","author":"Anuracpreeda","year":"2014","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.pep.2019.105532","article-title":"Schistosoma mansoni cathepsin D1: biochemical and biophysical characterization of the recombinant enzyme expressed in HEK293T cells","volume":"167","author":"Araujo-Montoya","year":"2020","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/bs.apar.2024.07.002_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2023.108628","article-title":"In vitro and in vivo studies on a group of chalcones find promising results as potential drugs against fascioliasis","volume":"255","author":"Artia","year":"2023","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib25","doi-asserted-by":"crossref","first-page":"543","DOI":"10.2307\/3280317","article-title":"Acidic thiol proteinase activity of Schistosoma mansoni egg extracts","volume":"65","author":"Asch","year":"1979","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib26","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.molimm.2007.05.021","article-title":"Proteases from Schistosoma mansoni cercariae cleave IgE at solvent exposed interdomain regions","volume":"45","author":"Aslam","year":"2008","journal-title":"Mol. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib27","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0305-0491(82)90215-2","article-title":"Neutral protease activities at different developmental stages of Schistosoma mansoni in mammalian hosts","volume":"72","author":"Auriault","year":"1982","journal-title":"Comp. Biochem. Physiol. Part B: Biochem. Mol. Biol."},{"key":"10.1016\/bs.apar.2024.07.002_bib28","first-page":"333","article-title":"A cyclohexanecarboxamide derivative with inhibitory effects on Schistosoma mansoni cercarial serine protease and penetration of mice skin by the parasite","volume":"66","author":"Bahgat","year":"2009","journal-title":"Acta Pol. Pharm."},{"key":"10.1016\/bs.apar.2024.07.002_bib29","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1017\/S0031182001001226","article-title":"Antibodies induced in mice by a DNA-construct coding for the elastase of Schistosoma mansoni recognize the enzyme in secretions and preacetabular glands of cercariae","volume":"124","author":"Bahgat","year":"2002","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib30","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1046\/j.1365-3024.2001.00417.x","article-title":"Infection induces antibodies against the cercarial secretions, but not against the cercarial elastases of Schistosoma mansoni, Schistosoma haematobium, Schistosoma japonicum and Trichobilharzia ocellata","volume":"23","author":"Bahgat","year":"2001","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib31","first-page":"181","article-title":"Differential inhibitory effect of newly synthesized pyridine-2-one derivatives on the cercarial serine protease activity of the parasite Schistosoma mansoni","volume":"63","author":"Bahgat","year":"2006","journal-title":"Acta Pol. Pharm."},{"key":"10.1016\/bs.apar.2024.07.002_bib32","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00436-002-0597-4","article-title":"Biochemical comparison of the serine protease (elastase) activities in cercarial secretions from Trichobilharzia ocellata and Schistosoma mansoni","volume":"88","author":"Bahgat","year":"2002","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib33","first-page":"597","article-title":"Humoral and cellular immune responses induced in mice by purified iridoid mixture that inhibits penetration of Schistosoma mansoni cercariae upon topical treatment of mice tails","volume":"35","author":"Bahgat","year":"2005","journal-title":"J. Egypt. Soc. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib34","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1007\/BF02977392","volume":"28","author":"Bahgat","year":"2005","journal-title":"Arch. Pharmacal Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0014-4894(02)00105-4","article-title":"A novel cathepsin B active site motif is shared by helminth bloodfeeders","volume":"101","author":"Baig","year":"2002","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib36","article-title":"The zoonotic helminth parasite Fasciola hepatica: virulence-associated cathepsin B and cathepsin L cysteine peptidases secreted by infective newly excysted juveniles (NEJ)","volume":"11","author":"Barbour","year":"2021","journal-title":"Animals (Basel)"},{"key":"10.1016\/bs.apar.2024.07.002_bib37","doi-asserted-by":"crossref","first-page":"24496","DOI":"10.1074\/jbc.270.41.24496","article-title":"Cloning and characterization of the Schistosoma japonicum aspartic proteinase involved in hemoglobin degradation","volume":"270","author":"Becker","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib38","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1515\/BC.2006.130","article-title":"Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite","volume":"387","author":"Beckham","year":"2006","journal-title":"Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib39","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1016\/j.biocel.2009.02.003","article-title":"A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites","volume":"41","author":"Beckham","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/bs.apar.2024.07.002_bib40","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1079\/JOH2002123","article-title":"Immunization with cathepsin L proteinases CL1 and CL2 secreted by Fasciola hepatica elicit a preferential type 1 response based on IgG2a antibodies in rats","volume":"76","author":"Bentancor","year":"2002","journal-title":"J. Helminthol."},{"key":"10.1016\/bs.apar.2024.07.002_bib41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1006\/expr.1999.4479","article-title":"Fasciola hepatica: parasite-secreted proteinases degrade all human IgG subclasses: determination of the specific cleavage sites and identification of the immunoglobulin fragments produced","volume":"94","author":"Berasain","year":"2000","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib42","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1021\/acsinfecdis.9b00237","article-title":"The proteasome as a drug target in the metazoan pathogen, Schistosoma mansoni","volume":"5","author":"Bibo-Verdugo","year":"2019","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0166-6851(94)90003-5","article-title":"Characterization of a native and recombinant Schistosoma haematobium serine protease inhibitor gene product","volume":"63","author":"Blanton","year":"1994","journal-title":"Mol. Biochemical Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib44","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1645\/0022-3395(2001)087[0237:GAIOTS]2.0.CO;2","article-title":"Gut-associated immunolocalization of the Schistosoma mansoni cysteine proteases, SmCL1 and SmCL2","volume":"87","author":"Bogitsh","year":"2001","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib45","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2307\/3281284","article-title":"Fluorescent histochemistry of acid proteases in adult Schistosoma mansoni and Schistosoma japonicum","volume":"69","author":"Bogitsh","year":"1983","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib46","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0014-4894(86)90025-1","article-title":"Schistosoma japonicum: ultrastructural localization of a hemoglobinase using mercury labeled pepstatin","volume":"62","author":"Bogitsh","year":"1986","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib47","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2307\/3283643","article-title":"Schistosoma japonicum: immunoinhibitory studies on hemoglobin digestion using heterologous antiserum to bovine cathepsin D","volume":"78","author":"Bogitsh","year":"1992","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib48","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/1471-2164-10-488","article-title":"Analysis of regulatory protease sequences identified through bioinformatic data mining of the Schistosoma mansoni genome","volume":"10","author":"Bos","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/bs.apar.2024.07.002_bib49","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s00436-010-1984-x","article-title":"Characterization and mRNA expression analysis of PI31, an endogenous proteasome inhibitor from Schistosoma mansoni","volume":"107","author":"Botelho-Machado","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0166-6851(95)02478-6","article-title":"Characterisation of a novel Kunitz-type molecule from the trematode Fasciola hepatica","volume":"74","author":"Bozas","year":"1995","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib51","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1006\/expr.1999.4478","article-title":"Schistosoma mansoni: differential expression of cathepsins L1 and L2 suggests discrete biological functions for each enzyme","volume":"94","author":"Brady","year":"2000","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib52","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/abbi.2000.1905","article-title":"Molecular modeling and substrate specificity of discrete cruzipain-like and cathepsin L-like cysteine proteinases of the human blood fluke Schistosoma mansoni","volume":"380","author":"Brady","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/bs.apar.2024.07.002_bib53","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1128\/IAI.67.1.368-374.1999","article-title":"Recombinant expression and localization of Schistosoma mansoni cathepsin L1 support its role in the degradation of host hemoglobin","volume":"67","author":"Brady","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/bs.apar.2024.07.002_bib54","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0166-6851(00)00351-0","article-title":"Proteolysis of human hemoglobin by schistosome cathepsin D","volume":"112","author":"Brindley","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib55","doi-asserted-by":"crossref","first-page":"38844","DOI":"10.1074\/jbc.M101934200","article-title":"Hemoglobin-degrading, aspartic proteases of blood-feeding parasites: substrate specificity revealed by homology models","volume":"276","author":"Brinkworth","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib56","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1186\/s13071-020-04260-6","article-title":"Identification of protective peptides of Fasciola hepatica-derived cathepsin L1 (FhCL1) in vaccinated sheep by a linear B-cell epitope mapping approach","volume":"13","author":"Buffoni","year":"2020","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib57","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.vetpar.2011.09.027","article-title":"Humoral immune response in goats immunised with cathepsin L1, peroxiredoxin and Sm14 antigen and experimentally challenged with Fasciola hepatica","volume":"185","author":"Buffoni","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.102970","article-title":"An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily","volume":"299","author":"Bu\u0161a","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib59","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1383-5769(97)00044-5","article-title":"Schistosoma japonicum and S. mansoni: effect of cyclosporin A on aspartic and cysteine hemoglobinolytic activities","volume":"47","author":"Caffrey","year":"1998","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005840","article-title":"Cysteine proteases as digestive enzymes in parasitic helminths","volume":"12","author":"Caffrey","year":"2018","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib61","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/S0014-5793(99)01798-6","article-title":"Identification of a cDNA encoding an active asparaginyl endopeptidase of Schistosoma mansoni and its expression in Pichia pastoris","volume":"466","author":"Caffrey","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/bs.apar.2024.07.002_bib62","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.pt.2004.03.004","article-title":"Blood \u2018n\u2019 guts: an update on schistosome digestive peptidases","volume":"20","author":"Caffrey","year":"2004","journal-title":"Trends Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib63","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1515\/BC.2005.041","article-title":"Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors","volume":"386","author":"Caffrey","year":"2005","journal-title":"Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib64","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s004360050204","article-title":"Schistosoma japonicum, S. mansoni, S. haematobium, S. intercalatum, and S. rodhaini: cysteine-class cathepsin activities in the vomitus of adult worms","volume":"83","author":"Caffrey","year":"1997","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib65","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.2307\/3284371","article-title":"Affinity isolation and characterization of the cathepsin B-like proteinase Sj31 from Schistosoma japonicum","volume":"83","author":"Caffrey","year":"1997","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib66","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s004360050310","article-title":"Cathepsin B-like activity predominates over cathepsin L-like activity in adult Schistosoma mansoni and S. japonicum","volume":"83","author":"Caffrey","year":"1997","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib67","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0166-6851(02)00022-1","article-title":"SmCB2, a novel tegumental cathepsin B from adult Schistosoma mansoni","volume":"121","author":"Caffrey","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib68","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1016\/j.biochi.2008.04.020","article-title":"A distinctive repertoire of cathepsins is expressed by juvenile invasive Fasciola hepatica","volume":"90","author":"Cancela","year":"2008","journal-title":"Biochimie"},{"key":"10.1016\/bs.apar.2024.07.002_bib69","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1017\/S0031182017001093","article-title":"Functional characterization of single-domain cystatin-like cysteine proteinase inhibitors expressed by the trematode Fasciola hepatica","volume":"144","author":"Cancela","year":"2017","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib70","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1515\/BC.2002.134","article-title":"Role of the prosegment of Fasciola hepatica cathepsin L1 in folding of the catalytic domain","volume":"383","author":"Cappetta","year":"2002","journal-title":"Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib71","first-page":"149","article-title":"Human fascioliasis: current epidemiological status and strategies for diagnosis, treatment, and control","volume":"11","author":"Caravedo","year":"2020","journal-title":"Res. Rep. Tropical Med."},{"key":"10.1016\/bs.apar.2024.07.002_bib72","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0166-6851(93)90172-T","article-title":"Cathepsin L proteinase secreted by Fasciola hepatica in vitro prevents antibody-mediated eosinophil attachment to newly excysted juveniles","volume":"62","author":"Carmona","year":"1993","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib73","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1017\/S0031182000077817","article-title":"A dipeptidylpeptidase secreted by Fasciola hepatica","volume":"109","author":"Carmona","year":"1994","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib74","doi-asserted-by":"crossref","first-page":"85S","DOI":"10.1042\/bst020085s","article-title":"A Fasciola hepatica cathepsin L proteinase prevents the adherence of eosinophils to newly excysted juveniles","volume":"20","author":"Carmona","year":"1992","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/bs.apar.2024.07.002_bib75","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0732-8893(01)00288-7","article-title":"Immunodiagnosis of fasciolosis using recombinant procathepsin L cystein proteinase","volume":"41","author":"Carnevale","year":"2001","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib76","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1017\/S0031182098003175","article-title":"Purification and partial characterization of kininogenase activity from Schistosoma mansoni adult worms","volume":"117","author":"Carvalho","year":"1998","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib77","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3389\/fimmu.2019.00552","article-title":"Cathepsin L3 from Fasciola hepatica induces NLRP3 inflammasome alternative activation in murine dendritic cells","volume":"10","author":"Celias","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib78","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1590\/S0074-02761998000700024","article-title":"Biochemical characterization of cathepsin D from adult Schistosoma mansoni worms. Mem\u00f3rias do Inst","volume":"93","author":"Cesari","year":"1998","journal-title":"Oswaldo Cruz"},{"key":"10.1016\/bs.apar.2024.07.002_bib79","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0165-2478(03)00084-1","article-title":"Immunogenicity of polymerizable synthetic peptides derived from a vaccine candidate against schistosomiasis: the asparaginyl endopeptidase (Sm32)","volume":"88","author":"Chacon","year":"2003","journal-title":"Immunol. Lett."},{"key":"10.1016\/bs.apar.2024.07.002_bib80","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.exppara.2012.04.008","article-title":"Molecular cloning and characterization of leucine aminopeptidase from Fasciola gigantica","volume":"131","author":"Changklungmoa","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib81","article-title":"Combination vaccines of Fasciola gigantica saposin-like protein-2 and leucine aminopeptidase","volume":"8","author":"Changklungmoa","year":"2023","journal-title":"Tropical Med. Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib82","doi-asserted-by":"crossref","first-page":"3653","DOI":"10.1007\/s00436-013-3553-6","article-title":"Immunization with recombinant leucine aminopeptidase showed protection against Fasciola gigantica in mice","volume":"112","author":"Changklungmoa","year":"2013","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib83","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.vetpar.2016.07.009","article-title":"Vaccine potential of recombinant cathepsinL1G against Fasciola gigantica in mice","volume":"226","author":"Changklungmoa","year":"2016","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib84","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.exppara.2013.06.010","article-title":"Vaccine potential of recombinant cathepsin B against Fasciola gigantica","volume":"135","author":"Chantree","year":"2013","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib85","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens12030395","article-title":"Type I cystatin derived from Fasciola gigantica suppresses macrophage-mediated inflammatory responses","volume":"12","author":"Chantree","year":"2023","journal-title":"Pathogens"},{"key":"10.1016\/bs.apar.2024.07.002_bib86","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.exppara.2012.07.011","article-title":"Characterization and expression of cathepsin B2 in Fasciola gigantica","volume":"132","author":"Chantree","year":"2012","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib87","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0304-4017(82)90039-5","article-title":"Proteolytic cleavage of immunoglobulin by enzymes released by Fasciola hepatica","volume":"11","author":"Chapman","year":"1982","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib88","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/0014-4894(86)90148-7","article-title":"Schistosoma mansoni: proteinase activity of \u201chemoglobinase\u201d from the digestive tract of adult worms","volume":"61","author":"Chappell","year":"1986","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib89","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1128\/jcm.27.1.196-198.1989","article-title":"Cloned Schistosoma mansoni proteinase (hemoglobinase) as a putative serodiagnostic reagent","volume":"27","author":"Chappell","year":"1989","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/bs.apar.2024.07.002_bib90","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2023.109959","article-title":"A promising new target to control fasciolosis: Fasciola hepatica leucine aminopeptidase 2","volume":"320","author":"Checa","year":"2023","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib91","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.3389\/fimmu.2019.01707","article-title":"The multitasking Fasciola gigantica cathepsin B interferes with various functions of goat peripheral blood mononuclear cells in vitro","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib92","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00436-016-5363-0","article-title":"Cysteine protease inhibitor of Schistosoma japonicum\u2014a parasite-derived negative immunoregulatory factor","volume":"116","author":"Chen","year":"2017","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib93","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1186\/s13071-015-1248-9","article-title":"Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis","volume":"8","author":"Chen","year":"2015","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib94","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/1756-3305-4-149","article-title":"Molecular characterization of cathepsin B from Clonorchis sinensis excretory\/secretory products and assessment of its potential for serodiagnosis of clonorchiasis","volume":"4","author":"Chen","year":"2011","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib95","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1007\/s00436-014-4006-6","article-title":"Characterization of the secreted cathepsin B cysteine proteases family of the carcinogenic liver fluke Clonorchis sinensis","volume":"113","author":"Chen","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib96","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.11912","article-title":"Schistosoma japonicum cystatin suppresses osteoclastogenesis via manipulating the NF\u2011kappaB signaling pathway","volume":"23","author":"Chen","year":"2021","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/bs.apar.2024.07.002_bib97","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/S0264-410X(01)00345-0","article-title":"DNA vaccination with asparaginyl endopeptidase (Sm32) from the parasite Schistosoma mansoni: anti-fecundity effect induced in mice","volume":"20","author":"Chlichlia","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib98","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s00436-001-0547-6","article-title":"Species-restricted antibody response against a DNA-construct coding for aspartic proteinase from Schistosoma japonicum","volume":"88","author":"Chlichlia","year":"2002","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib99","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1365-3024.2005.00751.x","article-title":"Schistosoma japonicum reveals distinct reactivity with antisera directed to proteases mediating host infection and invasion by cercariae of S. mansoni or S. haematobium","volume":"27","author":"Chlichlia","year":"2005","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib100","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3347\/kjp.2006.44.3.187","article-title":"Molecular and biochemical characterization of hemoglobinase, a cysteine proteinase, in Paragonimus westermani","volume":"44","author":"Choi","year":"2006","journal-title":"Korean J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib101","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13071-023-05694-4","article-title":"Clonorchis sinensis legumain promotes migration and invasion of cholangiocarcinoma cells via regulating tumor-related molecules","volume":"16","author":"Chu","year":"2023","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib102","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1017\/S0031182098003874","article-title":"Identification of a developmentally regulated Schistosoma mansoni serine protease homologous to mouse plasma kallikrein and human factor I","volume":"118","author":"Cocude","year":"1999","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib103","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1017\/S0031182097001546","article-title":"Molecular characterization of a partial sequence encoding a novel Schistosoma mansoni serine protease","volume":"115","author":"Cocude","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib104","doi-asserted-by":"crossref","first-page":"25356","DOI":"10.1021\/acsomega.4c03376","article-title":"Pharmacophore virtual screening identifies riboflavin as an inhibitor of the schistosome cathepsin B1 protease with antiparasitic activity","volume":"9","author":"Cogo","year":"2024","journal-title":"ACS Omega"},{"key":"10.1016\/bs.apar.2024.07.002_bib105","doi-asserted-by":"crossref","first-page":"11221","DOI":"10.1021\/bi00111a005","article-title":"Arresting tissue invasion of a parasite by protease inhibitors chosen with the aid of computer modeling","volume":"30","author":"Cohen","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/bs.apar.2024.07.002_bib106","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1021\/acs.jproteome.2c00299","article-title":"Fasciola hepatica cathepsin L zymogens: immuno-proteomic evidence for highly immunogenic zymogen-specific conformational epitopes to support diagnostics development","volume":"21","author":"Collett","year":"2022","journal-title":"J. Proteome Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib107","doi-asserted-by":"crossref","first-page":"17038","DOI":"10.1074\/jbc.M308831200","article-title":"Cathepsin L1, the major protease involved in liver fluke (Fasciola hepatica) virulence: propetide cleavage sites and autoactivation of the zymogen secreted from gastrodermal cells","volume":"279","author":"Collins","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib108","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0166-6851(01)00309-7","article-title":"Characterization of two cysteine proteinases secreted by Fasciola hepatica and demonstration of their kininogenase activity","volume":"116","author":"Cordova","year":"2001","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib109","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0020-7519(99)00017-X","article-title":"Use of a pre-selected epitope of cathepsin-L1 in a highly specific peptide-based immunoassay for the diagnosis of Fasciola hepatica infections in cattle","volume":"29","author":"Cornelissen","year":"1999","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib110","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S0020-7519(01)00175-8","article-title":"Early immunodiagnosis of fasciolosis in ruminants using recombinant Fasciola hepatica cathepsin L-like protease","volume":"31","author":"Cornelissen","year":"2001","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib111","article-title":"The use of cathepsin L1 (FhCL1) serological ELISA in sentinel screening for liver fluke on sheep farms","volume":"45","author":"Corrales","year":"2023","journal-title":"Vet. Parasitol.: Regional Stud. Rep."},{"key":"10.1016\/bs.apar.2024.07.002_bib112","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.molbiopara.2005.06.007","article-title":"Long-term suppression of cathepsin B levels by RNA interference retards schistosome growth","volume":"143","author":"Correnti","year":"2005","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib113","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.molbiopara.2009.04.005","article-title":"The major cathepsin L secreted by the invasive juvenile Fasciola hepatica prefers proline in the S2 subsite and can cleave collagen","volume":"167","author":"Corvo","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib114","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fmolb.2018.00040","article-title":"Substrate specificity of cysteine proteases beyond the S(2) pocket: mutagenesis and molecular dynamics investigation of Fasciola hepatica cathepsins L","volume":"5","author":"Corvo","year":"2018","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/bs.apar.2024.07.002_bib115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002269","article-title":"Dissecting the active site of the collagenolytic cathepsin L3 protease of the invasive stage of Fasciola hepatica","volume":"7","author":"Corvo","year":"2013","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib116","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fgene.2014.00206","article-title":"Evolutionary analysis of the cystatin family in three Schistosoma species","volume":"5","author":"Cuesta-Astroz","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/bs.apar.2024.07.002_bib117","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1074\/mcp.M500313-MCP200","article-title":"Identification of novel proteases and immunomodulators in the secretions of schistosome cercariae that facilitate host entry","volume":"5","author":"Curwen","year":"2006","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/bs.apar.2024.07.002_bib118","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/bs.apar.2019.01.001","article-title":"The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola","volume":"104","author":"Cwiklinski","year":"2019","journal-title":"Adv. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib119","article-title":"Targeting secreted protease\/anti-protease balance as a vaccine strategy against the helminth Fasciola hepatica","volume":"10","author":"Cwiklinski","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/bs.apar.2024.07.002_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2023.110049","article-title":"Fasciola hepatica antioxidant and protease-inhibitor cocktail recombinant vaccines administered five times elicit potent and sustained immune responses in sheep but do not confer protection","volume":"323","author":"Cwiklinski","year":"2023","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib121","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1128\/iai.64.4.1328-1334.1996","article-title":"Characterization of the cathepsin-like cysteine proteinases of Schistosoma mansoni","volume":"64","author":"Dalton","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/bs.apar.2024.07.002_bib122","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1017\/S003118209600830X","article-title":"The cysteine proteinases of Schistosoma mansoni cercariae","volume":"114","author":"Dalton","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib123","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1017\/S0031182000077052","article-title":"Asparaginyl endopeptidase activity in adult Schistosoma mansoni","volume":"111","author":"Dalton","year":"1995","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib124","doi-asserted-by":"crossref","first-page":"5066","DOI":"10.1128\/iai.64.12.5066-5074.1996","article-title":"Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin","volume":"64","author":"Dalton","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/bs.apar.2024.07.002_bib125","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.vetpar.2013.04.008","article-title":"Immunomodulatory molecules of Fasciola hepatica: candidates for both vaccine and immunotherapeutic development","volume":"195","author":"Dalton","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib126","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0166-6851(82)90059-7","article-title":"Antigenic properties of Schistosoma mansoni aminopeptidases: evolution during the development in mammalian hosts","volume":"6","author":"Damonneville","year":"1982","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib127","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.1007\/s00436-014-4075-6","article-title":"Molecular characterization of SjBIRP, another apoptosis inhibitor, from Schistosoma japonicum","volume":"113","author":"Dao","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib128","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1017\/S0031182097001303","article-title":"Schistosoma mansoni: anomalous immunogenic properties of a 27 kDa larval serine protease associated with protective immunity","volume":"115","author":"Darani","year":"1997","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib129","doi-asserted-by":"crossref","first-page":"12851","DOI":"10.1016\/S0021-9258(18)45284-2","article-title":"Cloning and gene expression of Schistosoma mansoni protease","volume":"262","author":"Davis","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/bbrc.1995.2737","article-title":"Characterization and cloning of the cathepsin L proteinases of Schistosoma japonicum","volume":"217","author":"Day","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/bs.apar.2024.07.002_bib131","article-title":"Structure, immunoreactivity, and in silico epitope determination of SmSPI S. mansoni serpin for immunodiagnostic application","volume":"9","author":"De Benedetti","year":"2021","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/bs.apar.2024.07.002_bib132","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010226","article-title":"Fasciola hepatica is refractory to complement killing by preventing attachment of mannose binding lectin (MBL) and inhibiting MBL-associated serine proteases (MASPs) with serpins","volume":"18","author":"De Marco Verissimo","year":"2022","journal-title":"PLoS Pathog."},{"key":"10.1016\/bs.apar.2024.07.002_bib133","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008510","article-title":"Fasciola hepatica serine protease inhibitor family (serpins): purposely crafted for regulating host proteases","volume":"14","author":"De Marco Verissimo","year":"2020","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib134","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1471-2172-11-56","article-title":"Rapid induction of IgE responses to a worm cysteine protease during murine pre-patent schistosome infection","volume":"11","author":"De Oliveira Fraga","year":"2010","journal-title":"BMC Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib135","doi-asserted-by":"crossref","first-page":"39316","DOI":"10.1074\/jbc.M607128200","article-title":"A multienzyme network functions in intestinal protein digestion by a platyhelminth parasite","volume":"281","author":"Delcroix","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib136","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.molbiopara.2014.10.001","article-title":"RNA interference in Fasciola hepatica newly excysted juveniles: long dsRNA induces more persistent silencing than siRNA","volume":"197","author":"Dell\u2019oca","year":"2014","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib137","first-page":"9817","article-title":"Molecular identification and characterization of leucine aminopeptidase 2, an excretory-secretory product of Clonorchis sinensis","volume":"39","author":"Deng","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib138","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1017\/S0031182007002995","article-title":"Patterns of gene expression in schistosomes: localization by whole mount in situ hybridization","volume":"134","author":"Dillon","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib139","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbrc.2022.03.005","article-title":"Schixator, a new FXa inhibitor from Schistosoma japonicum with antithrombotic effect and low bleeding risk","volume":"603","author":"Ding","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/bs.apar.2024.07.002_bib140","article-title":"Deubiquitinating enzymes as possible drug targets for schistosomiasis","volume":"217","author":"Do Patrocinio","year":"2021","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib141","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1007\/s00436-020-06686-4","article-title":"Inhibition of 19S proteasome deubiquitinating activity in Schistosoma mansoni affects viability, oviposition, and structural changes","volume":"119","author":"Do Patrocinio","year":"2020","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib142","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1017\/S0031182002002809","article-title":"Identification of a fibrinolytic enzyme in Schistosoma mansoni eggs and modulated blood fibrinogen metabolism in S. mansoni-infected mice","volume":"126","author":"Doenhoff","year":"2003","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib143","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00436-010-1943-6","article-title":"Cathepsins B1 and B2 in the neuropathogenic schistosome Trichobilharzia regenti: distinct gene expression profiles and presumptive roles throughout the life cycle","volume":"107","author":"Dole\u010dkov\u00e1","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib144","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ijpara.2008.06.010","article-title":"The functional expression and characterisation of a cysteine peptidase from the invasive stage of the neuropathogenic schistosome Trichobilharzia regenti","volume":"39","author":"Dole\u010dkov\u00e1","year":"2009","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib145","doi-asserted-by":"crossref","first-page":"399","DOI":"10.4161\/hv.27057","article-title":"Lipid core peptide targeting the cathepsin D hemoglobinase of Schistosoma mansoni as a component of a schistosomiasis vaccine","volume":"10","author":"Dougall","year":"2014","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/bs.apar.2024.07.002_bib146","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0141-0229(00)00259-3","article-title":"Stability studies on the cathepsin L proteinase of the helminth parasite, Fasciola hepatica","volume":"27","author":"Dowd","year":"2000","journal-title":"Enzyme Microb. Technol."},{"key":"10.1016\/bs.apar.2024.07.002_bib147","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1432-1033.1995.tb20805.x","article-title":"Fasciola hepatica cathepsin L proteinase cleaves fibrinogen and produces a novel type of fibrin clot","volume":"232","author":"Dowd","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/bs.apar.2024.07.002_bib148","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1432-1033.1994.tb18969.x","article-title":"Purification and characterisation of a second cathepsin L proteinase secreted by the parasitic trematode Fasciola hepatica","volume":"223","author":"Dowd","year":"1994","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/bs.apar.2024.07.002_bib149","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0166-6851(97)00090-X","article-title":"Isolation of a cDNA encoding Fasciola hepatica cathepsin L2 and functional expression in Saccharomyces cerevisiae","volume":"88","author":"Dowd","year":"1997","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib150","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1128\/IAI.00573-09","article-title":"Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses","volume":"78","author":"Dowling","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/bs.apar.2024.07.002_bib151","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4049\/jimmunol.130.1.1","article-title":"A monoclonal antibody from infected mice to a Schistosoma mansoni egg proteinase","volume":"130","author":"Dresden","year":"1983","journal-title":"J. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib152","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.molbiopara.2009.11.001","article-title":"Biolistic transformation of Schistosoma mansoni: studies with modified reporter-gene constructs containing regulatory regions of protease genes","volume":"170","author":"Dvo\u0159\u00e1k","year":"2010","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib153","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ijpara.2005.02.018","article-title":"Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition","volume":"35","author":"Dvo\u0159\u00e1k","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib154","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ijpara.2018.01.001","article-title":"Serine proteases in schistosomes and other trematodes","volume":"48","author":"Dvo\u0159\u00e1k","year":"2018","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib155","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.biochi.2007.08.013","article-title":"Differential use of protease families for invasion by schistosome cercariae","volume":"90","author":"Dvo\u0159\u00e1k","year":"2008","journal-title":"Biochimie"},{"key":"10.1016\/bs.apar.2024.07.002_bib156","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000449","article-title":"SmCL3, a gastrodermal cysteine protease of the human blood fluke Schistosoma mansoni","volume":"3","author":"Dvo\u0159\u00e1k","year":"2009","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib157","doi-asserted-by":"crossref","first-page":"66","DOI":"10.3389\/fcimb.2020.00066","article-title":"Isoforms of cathepsin B1 in neurotropic schistosomula of Trichobilharzia regenti differ in substrate preferences and a highly expressed catalytically inactive paralog binds cystatin","volume":"10","author":"Dvo\u0159\u00e1kov\u00e1","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/bs.apar.2024.07.002_bib158","doi-asserted-by":"crossref","DOI":"10.1016\/j.exppara.2023.108671","article-title":"Immune modulation of goat monocytes by Fasciola gigantica legumain-1 protein (Fg-LGMN-1)","volume":"256","author":"Ehsan","year":"2024","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib159","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1017\/S0031182017000658","article-title":"Schistosoma mansoni cercarial elastase (SmCE): differences in immunogenic properties of native and recombinant forms","volume":"144","author":"El-Faham","year":"2017","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib160","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1046\/j.1365-3156.1998.00298.x","article-title":"Diagnostic significance of Schistosoma mansoni proteins Sm31 and Sm32 in human schistosomiasis in an endemic area in Egypt","volume":"3","author":"El-Sayed","year":"1998","journal-title":"Tropical Med. Int. Health"},{"key":"10.1016\/bs.apar.2024.07.002_bib161","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fgene.2014.00119","article-title":"Induction of protective immune responses against schistosomiasis using functionally active cysteine peptidases","volume":"5","author":"El Ridi","year":"2014","journal-title":"Front. Genet."},{"key":"10.1016\/bs.apar.2024.07.002_bib162","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085401","article-title":"Cysteine peptidases as schistosomiasis vaccines with inbuilt adjuvanticity","volume":"9","author":"El Ridi","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/bs.apar.2024.07.002_bib163","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1645\/GE-1672.1","article-title":"Development and application of a fecal antigen diagnostic sandwich ELISA for estimating prevalence of Fasciola gigantica in cattle in central Java, Indonesia","volume":"95","author":"Estuningsih","year":"2009","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib164","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0020-7519(97)00096-9","article-title":"Evaluation of antigens of Fasciola gigantica as vaccines against tropical fasciolosis in cattle","volume":"27","author":"Estuningsih","year":"1997","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib165","first-page":"732","article-title":"Prolyl oligopeptidase in physiology and pathology","volume":"113","author":"Fajtov\u00e1","year":"2019","journal-title":"Chemicke Listy"},{"key":"10.1016\/bs.apar.2024.07.002_bib166","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003827","article-title":"Prolyl oligopeptidase from the blood fluke Schistosoma mansoni: from functional analysis to anti-schistosomal inhibitors","volume":"9","author":"Fajtov\u00e1","year":"2015","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib167","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0114505","article-title":"Fasciola hepatica Kunitz type molecule decreases dendritic cell activation and their ability to induce inflammatory responses","volume":"9","author":"Falcon","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/bs.apar.2024.07.002_bib168","doi-asserted-by":"crossref","first-page":"14973","DOI":"10.1021\/jp409604n","article-title":"Quantum mechanics-based scoring rationalizes the irreversible inactivation of parasitic Schistosoma mansoni cysteine peptidase by vinyl sulfone inhibitors","volume":"117","author":"Fanfrl\u00edk","year":"2013","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/bs.apar.2024.07.002_bib169","first-page":"339","article-title":"Evaluation of recombinant SjLAP and SjFBPA in detecting antibodies to Schistosoma japonicum","volume":"29","author":"Faustina","year":"2011","journal-title":"Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing. Za Zhi"},{"key":"10.1016\/bs.apar.2024.07.002_bib170","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0166-6851(90)90153-D","article-title":"Cloning and expression of Schistosoma mansoni protein Sm32 in a baculovirus vector","volume":"43","author":"Felleisen","year":"1990","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib171","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/j.1460-2075.1990.tb08120.x","article-title":"In vitro translation and processing of cathepsin B of Schistosoma mansoni","volume":"9","author":"Felleisen","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/bs.apar.2024.07.002_bib172","doi-asserted-by":"crossref","first-page":"1054502","DOI":"10.3389\/fpubh.2022.1054502","article-title":"High relatedness of bioinformatic data and realistic experimental works on the potentials of Fasciola hepatica and F. gigantica cathepsin L1 as a diagnostic and vaccine antigen","volume":"10","author":"Fereig","year":"2022","journal-title":"Front. Public Health"},{"key":"10.1016\/bs.apar.2024.07.002_bib173","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.parint.2016.09.015","article-title":"Differential distribution and biochemical characteristics of hydrolases among developmental stages of Schistosoma mansoni may offer new anti-parasite targets","volume":"66","author":"Fernandez-Delgado","year":"2017","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib174","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004834","article-title":"Identification of chalcones as Fasciola hepatica cathepsin L inhibitors using a comprehensive experimental and computational approach","volume":"10","author":"Ferraro","year":"2016","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib175","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24132348","article-title":"Cathepsin L inhibitors with activity against the liver fluke identified from a focus library of quinoxaline 1,4-di-N-oxide derivatives","volume":"24","author":"Ferraro","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/bs.apar.2024.07.002_bib176","doi-asserted-by":"crossref","DOI":"10.1002\/cmdc.202400305","article-title":"Flavonoid-quinoxaline hybrid compounds as cathepsin inhibitors against fascioliasis","author":"Ferraro","year":"2024","journal-title":"ChemMedChem"},{"key":"10.1016\/bs.apar.2024.07.002_bib177","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0014-4894(92)90124-S","article-title":"Schistosoma mansoni: cell-specific expression and secretion of a serine protease during development of cercariae","volume":"75","author":"Fishelson","year":"1992","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib178","doi-asserted-by":"crossref","first-page":"2666","DOI":"10.1128\/AAC.04601-14","article-title":"Synthesis of a sugar-based thiosemicarbazone series and structure-activity relationship versus the parasite cysteine proteases rhodesain, cruzain, and Schistosoma mansoni cathepsin B1","volume":"59","author":"Fonseca","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/bs.apar.2024.07.002_bib179","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1021\/acsinfecdis.4c00020","article-title":"Dual strategy to design new agents targeting Schistosoma mansoni: advancing phenotypic and SmCB1 inhibitors for improved efficacy","volume":"10","author":"Fuchs","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib180","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1186\/s13071-020-04104-3","article-title":"Therapeutic efficacy of Schistosoma japonicum cystatin on sepsis-induced cardiomyopathy in a mouse model","volume":"13","author":"Gao","year":"2020","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib181","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.vaccine.2018.01.020","article-title":"Antibody recognition of cathepsin L1-derived peptides in Fasciola hepatica-infected and\/or vaccinated cattle and identification of protective linear B-cell epitopes","volume":"36","author":"Garza-Cuartero","year":"2018","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib182","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens12070949","article-title":"Cystatins from the human liver fluke Opisthorchis viverrini: molecular characterization and functional analysis","volume":"12","author":"Geadkaew-Krenc","year":"2023","journal-title":"Pathogens"},{"key":"10.1016\/bs.apar.2024.07.002_bib183","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.molbiopara.2014.08.004","article-title":"A 170kDa multi-domain cystatin of Fasciola gigantica is active in the male reproductive system","volume":"196","author":"Geadkaew","year":"2014","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib184","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/expr.1994.1013","article-title":"Schistosoma mansoni: isolation and characterization of Smpi56, a novel serine protease inhibitor","volume":"78","author":"Ghendler","year":"1994","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib185","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/expr.1996.0051","article-title":"Schistosoma mansoni: evidence for a 28-kDa membrane-anchored protease on schistosomula","volume":"83","author":"Ghendler","year":"1996","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib186","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/0020-7519(95)00079-8","article-title":"Biochemical properties of purified cathepsin B from Schistosoma mansoni","volume":"25","author":"Ghoneim","year":"1995","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib187","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.1016\/j.vaccine.2010.06.039","article-title":"Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1)","volume":"28","author":"Golden","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib188","article-title":"Discovery of new Schistosoma mansoni aspartyl protease inhibitors by structure-based virtual screening","volume":"118","author":"Gomes","year":"2023","journal-title":"Mem\u00f3rias do Inst. Oswaldo Cruz"},{"key":"10.1016\/bs.apar.2024.07.002_bib189","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2023.110021","article-title":"Development of a novel method for diagnosis of fasciolosis based on cathepsin L7 in ruminants","volume":"322","author":"Gong","year":"2023","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002414","article-title":"The diagnosis of human fascioliasis by enzyme-linked immunosorbent assay (ELISA) using recombinant cathepsin L protease","volume":"7","author":"Gonzales Santana","year":"2013","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib191","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.parint.2015.12.008","article-title":"Immunocapture of circulating Schistosoma mansoni cathepsin B antigen (Sm31) by anti-Sm31 polyclonal antibodies","volume":"65","author":"Gonzalez","year":"2016","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib192","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002860","article-title":"Comparative assessment of ELISAs using recombinant saposin-like protein 2 and recombinant cathepsin L-1 from Fasciola hepatica for the serodiagnosis of human Fasciolosis","volume":"8","author":"Gottstein","year":"2014","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib193","first-page":"282","article-title":"Expression of an active cathepsin B-like protein Sm31 from Schistosoma mansoni in insect cells","volume":"43","author":"Gotz","year":"1992","journal-title":"Tropical Med. Parasitol."},{"issue":"Pt 3","key":"10.1016\/bs.apar.2024.07.002_bib194","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1042\/bj2900801","article-title":"Expression and partial characterization of a cathepsin B-like enzyme (Sm31) and a proposed \u2019haemoglobinase\u2019 (Sm32) from Schistosoma mansoni","volume":"290","author":"Gotz","year":"1993","journal-title":"Biochem. J."},{"key":"10.1016\/bs.apar.2024.07.002_bib195","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1021\/jm701311r","article-title":"Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens","volume":"51","author":"Gotz","year":"2008","journal-title":"J. Med. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib196","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S1383-5769(01)00068-X","article-title":"Molecular cloning and characterization of cathepsin L encoding genes from Fasciola gigantica","volume":"50","author":"Grams","year":"2001","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib197","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1107\/S0907444912008372","article-title":"Three-dimensional structure of a schistosome serpin revealing an unusual configuration of the helical subdomain","volume":"68","author":"Granzin","year":"2012","journal-title":"Acta Crystallogr. Sect. D: Biol. Crystallogr."},{"key":"10.1016\/bs.apar.2024.07.002_bib198","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1046\/j.1365-3024.1997.d01-199.x","article-title":"Recognition of Schistosoma mansoni cathepsins B and L by human IgG1 and IgG4 antibodies","volume":"19","author":"Grogan","year":"1997","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib199","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005919","article-title":"Cysteine proteases during larval migration and development of helminths in their final host","volume":"12","author":"Grote","year":"2018","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib200","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.exppara.2005.01.002","article-title":"Schistosoma mansoni: functional proteasomes are required for development in the vertebrate host","volume":"109","author":"Guerra-S\u00e1","year":"2005","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib201","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.vetpar.2010.11.003","article-title":"Evaluation of dipstick-ELISA using 28 kDa Fasciola gigantica cathepsin l cysteine proteinase (FgCL3) for serodiagnosis of fasciolosis in naturally infected goats","volume":"176","author":"Gupta","year":"2011","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib202","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010884","article-title":"A cercarial invadolysin interferes with the host immune response and facilitates infection establishment of Schistosoma mansoni","volume":"19","author":"Hambrook","year":"2023","journal-title":"PLoS Pathog."},{"key":"10.1016\/bs.apar.2024.07.002_bib203","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007393","article-title":"A metalloprotease produced by larval Schistosoma mansoni facilitates infection establishment and maintenance in the snail host by interfering with immune cell function","volume":"14","author":"Hambrook","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/bs.apar.2024.07.002_bib204","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.parint.2012.09.008","article-title":"Apoptosis phenomenon in the schistosomulum and adult worm life cycle stages of Schistosoma japonicum","volume":"62","author":"Han","year":"2013","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib205","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ijpara.2003.12.011","article-title":"Identification of a novel Fasciola hepatica cathepsin L protease containing protective epitopes within the propeptide","volume":"34","author":"Harmsen","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib206","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41541-023-00599-w","article-title":"Salmonella Typhimurium expressing chromosomally integrated Schistosoma mansoni Cathepsin B protects against schistosomiasis in mice","volume":"8","author":"Hassan","year":"2023","journal-title":"NPJ Vaccines"},{"key":"10.1016\/bs.apar.2024.07.002_bib207","doi-asserted-by":"crossref","first-page":"5580","DOI":"10.1016\/j.vaccine.2021.08.031","article-title":"Therapeutic activity of a Salmonella-vectored Schistosoma mansoni vaccine in a mouse model of chronic infection","volume":"39","author":"Hassan","year":"2021","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib208","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007490","article-title":"Vaccination against the digestive enzyme Cathepsin B using a YS1646 Salmonella enterica Typhimurium vector provides almost complete protection against Schistosoma mansoni challenge in a mouse model","volume":"13","author":"Hassan","year":"2019","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib209","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/bbrc.2000.3633","article-title":"Partial characterization of a novel cathepsin L-like protease from Fasciola hepatica","volume":"277","author":"Hawthorne","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/bs.apar.2024.07.002_bib210","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1006\/abio.1998.2736","article-title":"The synthesis and utilization of 2,4-dinitrophenyl-labeled irreversible peptidyl diazomethyl ketone inhibitors","volume":"261","author":"Hawthorne","year":"1998","journal-title":"Anal. Biochem."},{"key":"10.1016\/bs.apar.2024.07.002_bib211","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.mcp.2011.05.001","article-title":"Characterization and expression of a novel cystatin gene from Schistosoma japonicum","volume":"25","author":"He","year":"2011","journal-title":"Mol. Cell. Probes"},{"key":"10.1016\/bs.apar.2024.07.002_bib212","doi-asserted-by":"crossref","first-page":"27S","DOI":"10.1042\/bst019027s","article-title":"Characterisation of a cathepsin-B proteinase released by Fasciola hepatica (liver fluke)","volume":"19","author":"Heffernan","year":"1991","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/bs.apar.2024.07.002_bib213","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.3389\/fimmu.2019.02498","article-title":"Peptides derived of Kunitz-type serine protease inhibitor as potential vaccine against experimental Schistosomiasis","volume":"10","author":"Hernandez-Goenaga","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib214","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1017\/S0022149X14000686","article-title":"Construction and evaluation of a chimeric protein made from Fasciola hepatica leucine aminopeptidase and cathepsin L1","volume":"90","author":"Hernandez-Guzman","year":"2016","journal-title":"J. Helminthol."},{"key":"10.1016\/bs.apar.2024.07.002_bib215","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003759","article-title":"Insights into the interactions of Fasciola hepatica cathepsin L3 with a substrate and potential novel inhibitors through in silico approaches","volume":"9","author":"Hernandez Alvarez","year":"2015","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib216","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0166-6851(94)90130-9","article-title":"Cloning of a protease gene family of Fasciola hepatica by the polymerase chain reaction","volume":"64","author":"Heussler","year":"1994","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib217","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1017\/S0031182098003746","article-title":"Dipeptidyl peptidase I and III activities of adult schistosomes","volume":"118","author":"Hola-Jamriska","year":"1999","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib218","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1006\/prep.2000.1261","article-title":"Functional expression of dipeptidyl peptidase I (Cathepsin C) of the oriental blood fluke Schistosoma japonicum in Trichoplusia ni insect cells","volume":"19","author":"Hola-Jamriska","year":"2000","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/bs.apar.2024.07.002_bib219","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1046\/j.1432-1327.1998.2550527.x","article-title":"Cathepsin C from Schistosoma japonicum--cDNA encoding the preproenzyme and its phylogenetic relationships","volume":"255","author":"Hola-Jamriska","year":"1998","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/bs.apar.2024.07.002_bib220","first-page":"7312","article-title":"Schistosoma japonicum serine protease inhibitor increases endothelial barrier function","volume":"10","author":"Hong","year":"2017","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/bs.apar.2024.07.002_bib221","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002766","article-title":"Trypsin- and Chymotrypsin-like serine proteases in Schistosoma mansoni\u2014\u2018the undiscovered country\u2019","volume":"8","author":"Horn","year":"2014","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib222","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1021\/cb100411v","article-title":"Mapping the pro-peptide of the Schistosoma mansoni cathepsin B1 drug target: modulation of inhibition by heparin and design of mimetic inhibitors","volume":"6","author":"Horn","year":"2011","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/bs.apar.2024.07.002_bib223","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/S0264-410X(98)00391-0","article-title":"Recombinant vaccinia viruses and gene gun vectors expressing the large subunit of Schistosoma mansoni calpain used in a murine immunization-challenge model","volume":"17","author":"Hota-Mitchell","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib224","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/S0264-410X(97)00081-9","article-title":"Protection against Schistosoma mansoni infection with a recombinant baculovirus-expressed subunit of calpain","volume":"15","author":"Hota-Mitchell","year":"1997","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib225","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1007\/s00436-014-4104-5","article-title":"Evaluation of protective immune response in mice by vaccination the recombinant adenovirus for expressing Schistosoma japonicum inhibitor apoptosis protein","volume":"113","author":"Hu","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib226","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s00436-020-06916-9","article-title":"Mechanism by which the combination of SjCL3 and SjGAPDH protects against Schistosoma japonicum infection","volume":"120","author":"Huang","year":"2021","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib227","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1007\/s00436-020-06647-x","article-title":"Characteristics and function of cathepsin L3 from Schistosoma japonicum","volume":"119","author":"Huang","year":"2020","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib228","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1107\/S0907444998008658","article-title":"Purification and crystallization of a novel membrane-anchored protein: the Schistosoma haematobium serpin","volume":"55","author":"Huang","year":"1999","journal-title":"Acta Crystallogr. Sect. D: Biol. Crystallogr."},{"key":"10.1016\/bs.apar.2024.07.002_bib229","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00436-008-1219-6","article-title":"Identification and characterization of a serine protease inhibitor of Paragonimus westermani","volume":"104","author":"Hwang","year":"2009","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib230","doi-asserted-by":"crossref","first-page":"10308","DOI":"10.1038\/s41598-022-14419-z","article-title":"Transcriptomic and proteomic profiling of peptidase expression in Fasciola hepatica eggs developing at host\u2019s body temperature","volume":"12","author":"Ilgov\u00e1","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.apar.2024.07.002_bib231","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0167-4781(99)00051-2","article-title":"Schistosoma TOR (trispanning orphan receptor), a novel, antigenic surface receptor of the blood-dwelling, Schistosoma parasite","volume":"1445","author":"Inal","year":"1999","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Gen. Struct. Expr."},{"key":"10.1016\/bs.apar.2024.07.002_bib232","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0014-5793(00)01304-1","article-title":"A Schistosoma protein, Sh-TOR, is a novel inhibitor of complement which binds human C2","volume":"470","author":"Inal","year":"2000","journal-title":"FEBS Lett."},{"key":"10.1016\/bs.apar.2024.07.002_bib233","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001337","article-title":"Proteomic analysis of human skin treated with larval schistosome peptidases reveals distinct invasion strategies among species of blood flukes","volume":"5","author":"Ingram","year":"2011","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib234","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001589","article-title":"Investigation of the proteolytic functions of an expanded cercarial elastase gene family in Schistosoma mansoni","volume":"6","author":"Ingram","year":"2012","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib235","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.diagmicrobio.2005.05.010","article-title":"Potent epitopes derived from Fasciola gigantica cathepsin L1 in peptide-based immunoassay for the serodiagnosis of human fascioliasis","volume":"53","author":"Intapan","year":"2005","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib236","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00239-002-2434-x","article-title":"The evolution of enzyme specificity in Fasciola spp","volume":"57","author":"Irving","year":"2003","journal-title":"J. Mol. Evol."},{"key":"10.1016\/bs.apar.2024.07.002_bib237","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2023.109901","article-title":"Development of an enzyme linked immunosorbent assay using recombinant cathepsin B5 antigen for sero-surveillance of bovine tropical fasciolosis","volume":"316","author":"Jacob","year":"2023","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib238","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1515\/BC.2003.179","article-title":"Aza-peptide epoxides: potent and selective inhibitors of Schistosoma mansoni and pig kidney legumains (asparaginyl endopeptidases)","volume":"384","author":"James","year":"2003","journal-title":"Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib239","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3347\/kjp.2011.49.3.245","article-title":"Parasitic helminth cystatin inhibits DSS-induced intestinal inflammation via IL-10(+)F4\/80(+) macrophage recruitment","volume":"49","author":"Jang","year":"2011","journal-title":"Korean J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib240","doi-asserted-by":"crossref","first-page":"806","DOI":"10.4049\/jimmunol.157.2.806","article-title":"Calpain is the target antigen of a Th1 clone that transfers protective immunity against Schistosoma mansoni","volume":"157","author":"Jankovic","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib241","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.vetpar.2008.10.099","article-title":"Vaccination against fasciolosis by a multivalent vaccine of stage-specific antigens","volume":"160","author":"Jayaraj","year":"2009","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib242","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1186\/s13071-022-05556-5","article-title":"Characterization of glutamate carboxypeptidase 2 orthologs in trematodes","volume":"15","author":"Jedli\u010dkov\u00e1","year":"2022","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib243","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/bip.20788","article-title":"Fasciola gigantica cathepsin L proteinase-based synthetic peptide for immunodiagnosis and prevention of sheep fasciolosis","volume":"90","author":"Je\u017eek","year":"2008","journal-title":"Biopolymers"},{"key":"10.1016\/bs.apar.2024.07.002_bib244","article-title":"Development of subunit selective proteasome substrates for Schistosoma species","author":"Jiang","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/bs.apar.2024.07.002_bib245","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1021\/acsinfecdis.0c00644","article-title":"Azanitrile inhibitors of the SmCB1 protease target are lethal to Schistosoma mansoni: structural and mechanistic insights into chemotype reactivity","volume":"7","author":"J\u00edlkov\u00e1","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib246","first-page":"3","article-title":"Cathepsin B1 from the human blood fluke: a drug target for treatment of Schistosomiasis","volume":"112","author":"J\u00edlkov\u00e1","year":"2018","journal-title":"Chemicke Listy"},{"key":"10.1016\/bs.apar.2024.07.002_bib247","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-0716-0635-3_12","article-title":"Structural and functional characterization of Schistosoma mansoni cathepsin B1","volume":"2151","author":"J\u00edlkov\u00e1","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/bs.apar.2024.07.002_bib248","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1016\/j.str.2014.09.015","article-title":"Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch","volume":"22","author":"J\u00edlkov\u00e1","year":"2014","journal-title":"Structure"},{"key":"10.1016\/bs.apar.2024.07.002_bib249","doi-asserted-by":"crossref","first-page":"35770","DOI":"10.1074\/jbc.M111.271304","article-title":"Structural basis for inhibition of cathepsin B drug target from the human blood fluke, Schistosoma mansoni","volume":"286","author":"J\u00edlkov\u00e1","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib250","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1021\/acsinfecdis.0c00501","article-title":"Druggable hot spots in the Schistosomiasis cathepsin B1 target identified by functional and binding mode analysis of potent vinyl sulfone inhibitors","volume":"7","author":"J\u00edlkov\u00e1","year":"2021","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib251","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1002\/pmic.200700613","article-title":"Identification of a serodiagnostic antigen, legumain, by immunoproteomic analysis of excretory-secretory products of Clonorchis sinensis adult worms","volume":"9","author":"Ju","year":"2009","journal-title":"Proteomics"},{"key":"10.1016\/bs.apar.2024.07.002_bib252","doi-asserted-by":"crossref","DOI":"10.1016\/j.pep.2024.106429","article-title":"Recombinant protein production and functional analysis of a M60-like-2 metallopeptidase enzyme from the carcinogenic liver fluke Opisthorchis viverrini","volume":"216","author":"Jumpajan","year":"2024","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/bs.apar.2024.07.002_bib253","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00436-007-0831-1","article-title":"Characterization of cysteine proteases from the carcinogenic liver fluke, Opisthorchis viverrini","volume":"102","author":"Kaewpitoon","year":"2008","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib254","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.molbiopara.2009.11.006","article-title":"A family of cathepsin F cysteine proteases of Clonorchis sinensis is the major secreted proteins that are expressed in the intestine of the parasite","volume":"170","author":"Kang","year":"2010","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib255","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molbiopara.2011.11.009","article-title":"Comparative biochemical and functional properties of two leucine aminopeptidases of Clonorchis sinensis","volume":"182","author":"Kang","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib256","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00436-013-3624-8","article-title":"Identification and characterization of the second cysteine protease inhibitor of Clonorchis sinensis (CsStefin-2)","volume":"113","author":"Kang","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib257","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.molbiopara.2013.07.001","article-title":"Defining the regulatory and inhibitory elements within the prodomain of CsCF-6, a cathepsin F cysteine protease of Clonorchis sinensis","volume":"190","author":"Kang","year":"2013","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib258","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens10091128","article-title":"pH-Dependent structural dynamics of cathepsin D-family aspartic peptidase of Clonorchis sinensis","volume":"10","author":"Kang","year":"2021","journal-title":"Pathogens"},{"key":"10.1016\/bs.apar.2024.07.002_bib259","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.exppara.2015.03.015","article-title":"Characterization of a gut-associated asparaginyl endopeptidase of Clonorchis sinensis","volume":"153","author":"Kang","year":"2015","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib260","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.molbiopara.2011.02.010","article-title":"Identification and functional characterization of CsStefin-1, a cysteine protease inhibitor of Clonorchis sinensis","volume":"177","author":"Kang","year":"2011","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib261","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.actatropica.2010.06.007","article-title":"Identification and characterization of a serine protease inhibitor of Clonorchis sinensis","volume":"116","author":"Kang","year":"2010","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib262","doi-asserted-by":"crossref","first-page":"671","DOI":"10.3347\/kjp.2019.57.6.671","article-title":"Partial characterization of two cathepsin D family aspartic peptidases of Clonorchis sinensis","volume":"57","author":"Kang","year":"2019","journal-title":"Korean J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib263","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3347\/kjp.1995.33.4.323","article-title":"A cysteine protease of Paragonimus westermani eggs","volume":"33","author":"Kang","year":"1995","journal-title":"Korean J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib264","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/S0031182003004335","article-title":"A cathepsin F of adult Clonorchis sinensis and its phylogenetic conservation in trematodes","volume":"128","author":"Kang","year":"2004","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib265","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/s13071-015-0924-0","article-title":"Development of a multiplex fluorescence immunological assay for the simultaneous detection of antibodies against Cooperia oncophora, Dictyocaulus viviparus and Fasciola hepatica in cattle","volume":"8","author":"Karanikola","year":"2015","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib266","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0166-6851(91)90078-K","article-title":"Molecular cloning and sequence analysis of a calcium-activated neutral protease (calpain) from Schistosoma mansoni","volume":"49","author":"Karcz","year":"1991","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib267","doi-asserted-by":"crossref","first-page":"640","DOI":"10.4161\/hv.27576","article-title":"Complement plays a minimal role in Sm-p80-mediated protection against Schistosoma mansoni","volume":"10","author":"Karmakar","year":"2014","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/bs.apar.2024.07.002_bib268","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.vaccine.2013.12.057","article-title":"Cross-species protection: Schistosoma mansoni Sm-p80 vaccine confers protection against Schistosoma haematobium in hamsters and baboons","volume":"32","author":"Karmakar","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib269","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1093\/infdis\/jiu031","article-title":"Use of an Sm-p80-based therapeutic vaccine to kill established adult schistosome parasites in chronically infected baboons","volume":"209","author":"Karmakar","year":"2014","journal-title":"J. Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib270","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1017\/S0031182007002910","article-title":"Comparison of cysteine peptidase activities in Trichobilharzia regenti and Schistosoma mansoni cercariae","volume":"134","author":"Ka\u0161n\u00fd","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib271","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/978-1-4419-8414-2_9","article-title":"Cathepsins B1 and B2 of Trichobilharzia SPP., bird schistosomes causing cercarial dermatitis","volume":"712","author":"Ka\u0161n\u00fd","year":"2011","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/bs.apar.2024.07.002_bib272","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0065-308X(09)69004-7","article-title":"Chapter 4. Peptidases of trematodes","volume":"69","author":"Ka\u0161n\u00fd","year":"2009","journal-title":"Adv. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib273","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1016\/j.vaccine.2007.01.057","article-title":"Enteral vaccination of rats against Fasciola hepatica using recombinant cysteine proteinase (cathepsin L1)","volume":"25","author":"Kesik","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib274","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.ijpara.2005.05.001","article-title":"A new multi-domain member of the cystatin superfamily expressed by Fasciola hepatica","volume":"35","author":"Khaznadji","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib275","first-page":"291","article-title":"Serine proteases activity in miracidia of Fasciola hepatica and effects of chemical and herbal inhibitors","volume":"12","author":"Kianifard","year":"2021","journal-title":"Vet. Res. Forum"},{"key":"10.1016\/bs.apar.2024.07.002_bib276","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000593","article-title":"Electroporation facilitates introduction of reporter transgenes and virions into schistosome eggs","volume":"4","author":"Kines","year":"2010","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib277","first-page":"319","article-title":"Immunological analysis of cloned Schistosoma mansoni antigens Sm31 and Sm32 with sera of schistosomiasis patients","volume":"42","author":"Klinkert","year":"1991","journal-title":"Tropical Med. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib278","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0014-5793(94)00893-0","article-title":"Sequence and structure similarities of cathepsin B from the parasite Schistosoma mansoni and human liver","volume":"351","author":"Klinkert","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1016\/bs.apar.2024.07.002_bib279","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0166-6851(89)90025-X","article-title":"Primary structures of Sm31\/32 diagnostic proteins of Schistosoma mansoni and their identification as proteases","volume":"33","author":"Klinkert","year":"1989","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib280","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/0166-6851(87)90088-0","article-title":"Cloning of diagnostic 31\/32 kilodalton antigens of Schistosoma mansoni","volume":"25","author":"Klinkert","year":"1987","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib281","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0166-6851(88)90042-4","article-title":"Expression of diagnostic 31\/32 kilodalton proteins of Schistosoma mansoni as fusions with bacteriophage MS2 polymerase","volume":"27","author":"Klinkert","year":"1988","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib282","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1590\/S0074-02762007000100014","article-title":"Aspartic protease activities of schistosomes cleave mammalian hemoglobins in a host-specific manner","volume":"102","author":"Koehler","year":"2007","journal-title":"Mem\u00f3rias do Inst. Oswaldo Cruz"},{"key":"10.1016\/bs.apar.2024.07.002_bib283","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0014-4894(85)90019-0","article-title":"Schistosoma japonicum: biochemistry and cytochemistry of dipeptidyl aminopeptidase-II-like activity in adults","volume":"60","author":"Kramer","year":"1985","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib284","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.molbiopara.2007.03.006","article-title":"Optimizing gene suppression in schistosomes using RNA interference","volume":"153","author":"Krautz-Peterson","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib285","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.molbiopara.2007.12.011","article-title":"Schistosome asparaginyl endopeptidase (legumain) is not essential for cathepsin B1 activation in vivo","volume":"159","author":"Krautz-Peterson","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib286","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.actatropica.2015.06.020","article-title":"Vaccine potential of recombinant pro- and mature cathepsinL1 against fasciolosis gigantica in mice","volume":"150","author":"Kueakhai","year":"2015","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib287","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2021.102353","article-title":"The combined recombinant cathepsin L1H and cathepsin B3 vaccine against Fasciola gigantica infection","volume":"83","author":"Kueakhai","year":"2021","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib288","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.vetpar.2012.11.021","article-title":"Evaluation of a recombinant cathepsin L1 ELISA and comparison with the Pourquier and ES ELISA for the detection of antibodies against Fasciola hepatica","volume":"193","author":"Kuerpick","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib289","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exppara.2004.11.001","article-title":"Schistosoma japonicum: localization of calpain in the penetration glands and secretions of cercariae","volume":"109","author":"Kumagai","year":"2005","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib290","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2022.102540","article-title":"Calpain inhibitor suppresses both extracellular vesicle-mediated secretion of miRNAs and egg production from paired adults of Schistosoma japonicum","volume":"87","author":"Kumagai","year":"2022","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib291","doi-asserted-by":"crossref","first-page":"456","DOI":"10.6026\/97320630009456","article-title":"In-silico analysis of caspase-3 and -7 proteases from blood-parasitic Schistosoma species (Trematoda) and their human host","volume":"9","author":"Kumar","year":"2013","journal-title":"Bioinformation"},{"key":"10.1016\/bs.apar.2024.07.002_bib292","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1016\/j.ijid.2008.03.033","article-title":"Asparaginyl endopeptidase from the carcinogenic liver fluke, Opisthorchis viverrini, and its potential for serodiagnosis","volume":"12","author":"Laha","year":"2008","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib293","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1080\/21505594.2021.1996520","article-title":"Pathogenicity and virulence of the liver flukes Fasciola hepatica and Fasciola Gigantica that cause the zoonosis Fasciolosis","volume":"12","author":"Lalor","year":"2021","journal-title":"Virulence"},{"key":"10.1016\/bs.apar.2024.07.002_bib294","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/bj2010137","article-title":"Purification and properties of a proteolytic enzyme from the cercariae of the human trematode parasite Schistosoma mansoni","volume":"201","author":"Landsperger","year":"1982","journal-title":"Biochem. J."},{"key":"10.1016\/bs.apar.2024.07.002_bib295","doi-asserted-by":"crossref","first-page":"6921","DOI":"10.1128\/IAI.71.12.6921-6932.2003","article-title":"Cloning and expression of the major secreted cathepsin B-like protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection","volume":"71","author":"Law","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/bs.apar.2024.07.002_bib296","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.pathol.2018.01.004","article-title":"Schistosoma egg-induced liver pathology resolution by Sm-p80-based schistosomiasis vaccine in baboons","volume":"50","author":"Le","year":"2018","journal-title":"Pathology"},{"key":"10.1016\/bs.apar.2024.07.002_bib297","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1007\/s00436-014-3757-4","article-title":"Simultaneous priming with DNA encoding Sm-p80 and boosting with Sm-p80 protein confers protection against challenge infection with Schistosoma mansoni in mice","volume":"113","author":"Le","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib298","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms12061164","article-title":"Molecular characterization and functional analysis of a Schistosoma mansoni serine protease inhibitor, Smserpin-p46","volume":"12","author":"Lee","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/bs.apar.2024.07.002_bib299","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1016\/j.vaccine.2005.11.062","article-title":"Vaccination with DNA encoding cysteine proteinase confers protective immune response to rats infected with Clonorchis sinensis","volume":"24","author":"Lee","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib300","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1007\/s11033-012-2475-1","article-title":"The biochemical and immunological characterization of two serpins from Clonorchis sinensis","volume":"40","author":"Lei","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/bs.apar.2024.07.002_bib301","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006446","article-title":"SmSP2: a serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties","volume":"12","author":"Leontovy\u010d","year":"2018","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib302","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/s13071-017-2162-0","article-title":"Therapeutic effect of Schistosoma japonicum cystatin on bacterial sepsis in mice","volume":"10","author":"Li","year":"2017","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib303","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.bbrc.2018.06.109","article-title":"RNA interference in vivo in Schistosoma japonicum: establishing and optimization of RNAi mediated suppression of gene expression by long dsRNA in the intra-mammalian life stages of worms","volume":"503","author":"Li","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/bs.apar.2024.07.002_bib304","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1007\/s00436-011-2749-x","article-title":"Serological diagnosis of clonorchiasis: using a recombinant propeptide of cathepsin L proteinase from Clonorchis sinensis as a candidate antigen","volume":"110","author":"Li","year":"2012","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib305","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s00436-009-1406-0","article-title":"Molecular cloning and analysis of stage and tissue-specific expression of Cathepsin L-like protease from Clonorchis sinensis","volume":"105","author":"Li","year":"2009","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib306","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00436-012-2885-y","article-title":"41.5-kDa Cathepsin L protease from Clonorchis sinensis: expression, characterization, and serological reactivity of one excretory-secretory antigen","volume":"111","author":"Li","year":"2012","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib307","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/infdis\/171.2.416","article-title":"Preferential recognition by human IgE and IgG4 of a species-specific Schistosoma haematobium serine protease inhibitor","volume":"171","author":"Li","year":"1995","journal-title":"J. Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib308","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1007\/s00436-014-4027-1","article-title":"Identification, immunolocalization, and characterization analyses of an exopeptidase of papain superfamily, (cathepsin C) from Clonorchis sinensis","volume":"113","author":"Liang","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib309","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4269\/ajtmh.1999.60.487","article-title":"Blockage of skin invasion by schistosome cercariae by serine protease inhibitors","volume":"60","author":"Lim","year":"1999","journal-title":"Am. J. Tropical Med. Hyg."},{"key":"10.1016\/bs.apar.2024.07.002_bib310","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1017\/S0031182020000797","article-title":"Evaluation of immune response to Bacillus subtilis spores expressing Clonorchis sinensis serpin3","volume":"147","author":"Lin","year":"2020","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib311","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1074\/jbc.271.3.1717","article-title":"Cathepsin B of Schistosoma mansoni. Purification and activation of the recombinant proenzyme secreted by Saccharomyces cerevisiae","volume":"271","author":"Lipps","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib312","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1007\/s00436-016-5140-0","article-title":"Schistosoma japonicum cystatin attenuates murine collagen-induced arthritis","volume":"115","author":"Liu","year":"2016","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib313","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ijpara.2018.11.011","article-title":"14-3-3 protein and ubiquitin C acting as SjIAP interaction partners facilitate tegumental integrity in Schistosoma japonicum","volume":"49","author":"Liu","year":"2019","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib314","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006654","article-title":"Schistosoma japonicum IAP and Teg20 safeguard tegumental integrity by inhibiting cellular apoptosis","volume":"12","author":"Liu","year":"2018","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib315","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1021\/acs.jproteome.5b00465","article-title":"Proteomic analysis on cercariae and schistosomula in reference to potential proteases involved in host invasion of Schistosoma japonicum larvae","volume":"14","author":"Liu","year":"2015","journal-title":"J. Proteome Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib316","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003856","article-title":"Expression profile of the Schistosoma japonicum degradome reveals differential protease expression patterns and potential anti-schistosomal intervention targets","volume":"10","author":"Liu","year":"2014","journal-title":"PLoS Computational Biol."},{"key":"10.1016\/bs.apar.2024.07.002_bib317","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2021.109517","article-title":"Diagnosis of sheep fasciolosis caused by Fasciola hepatica using cathepsin L enzyme-linked immunosorbent assays (ELISA)","volume":"298","author":"Lopez Corrales","year":"2021","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib318","doi-asserted-by":"crossref","first-page":"7074","DOI":"10.1074\/jbc.M111.313304","article-title":"A blood fluke serine protease inhibitor regulates an endogenous larval elastase","volume":"287","author":"Lopez Quezada","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib319","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.compbiolchem.2018.11.012","article-title":"In silico modeling and structural analysis of asparaginyl endopeptidase of Schistosoma mansoni (Sm32): immunological and drug target implications","volume":"78","author":"Lorenzo","year":"2019","journal-title":"Computational Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib320","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.exppara.2005.07.007","article-title":"Schistosoma: cross-reactivity and antigenic community among different species","volume":"111","author":"Losada","year":"2005","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib321","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000369","article-title":"The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease","volume":"3","author":"Lowther","year":"2009","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib322","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1007\/s00436-012-3086-4","article-title":"Molecular characterization of a cytokine-induced apoptosis inhibitor from Schistosoma japonicum","volume":"111","author":"Luo","year":"2012","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib323","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1007\/s00436-019-06223-y","article-title":"Identification and characteristics of a cathepsin L-like cysteine protease from Clonorchis sinensis","volume":"118","author":"Ma","year":"2019","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib324","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1007\/s00436-019-06410-x","article-title":"Schistosoma japonicum cathepsin B as potential diagnostic antigen for Asian zoonotic schistosomiasis","volume":"118","author":"Macalanda","year":"2019","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib325","doi-asserted-by":"crossref","first-page":"9057","DOI":"10.1016\/j.vaccine.2011.09.020","article-title":"The recombinant gut-associated M17 leucine aminopeptidase in combination with different adjuvants confers a high level of protection against Fasciola hepatica infection in sheep","volume":"29","author":"Maggioli","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib326","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.molbiopara.2017.11.006","article-title":"Expression, purification and characterization of two leucine aminopeptidases of the blood fluke, Schistosoma mansoni","volume":"219","author":"Maggioli","year":"2018","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib327","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009007","article-title":"S. mansoni SmKI-1 Kunitz-domain: leucine point mutation at P1 site generates enhanced neutrophil elastase inhibitory activity","volume":"15","author":"Mambelli","year":"2021","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib328","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1128\/CVI.00338-07","article-title":"Leucine aminopeptidase is an immunodominant antigen of Fasciola hepatica excretory and secretory products in human infections","volume":"15","author":"Marcilla","year":"2008","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib329","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4049\/jimmunol.141.1.273","article-title":"Proteases secreted by transforming schistosomula of Schistosoma mansoni promote resistance to killing by complement","volume":"141","author":"Marikovsky","year":"1988","journal-title":"J. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib330","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/j.1365-3024.1990.tb00976.x","article-title":"Schistosoma mansoni: localization of the 28 kDa secreted protease in cercaria","volume":"12","author":"Marikovsky","year":"1990","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib331","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1007\/s00436-018-5809-7","article-title":"Comparison of recombinant cathepsins L1, L2, and L5 as ELISA targets for serodiagnosis of bovine and ovine fascioliasis","volume":"117","author":"Martinez-Sernandez","year":"2018","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib332","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2024.107199","article-title":"Production and immunological characterization of the novel single-chain variable fragment (scFv) antibodies against the epitopes on Opisthorchis viverrini cathepsin F (OvCatF)","volume":"254","author":"Martviset","year":"2024","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib333","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.molbiopara.2010.10.005","article-title":"The proteasome-ubiquitin pathway in the Schistosoma mansoni egg has development- and morphology-specific characteristics","volume":"175","author":"Mathieson","year":"2011","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib334","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0166-6851(02)00026-9","article-title":"Substrate specificity of schistosome versus human legumain determined by P1-P3 peptide libraries","volume":"121","author":"Mathieu","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib335","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.ijpara.2004.01.008","article-title":"Leucine aminopeptidase of the human blood flukes, Schistosoma mansoni and Schistosoma japonicum","volume":"34","author":"Mccarthy","year":"2004","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib336","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1017\/S0031182000076782","article-title":"Characterization of the cysteine proteinases of the common liver fluke Fasciola hepatica using novel, active-site directed affinity labels","volume":"106","author":"Mcginty","year":"1993","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib337","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.ijpara.2007.10.007","article-title":"The silencing of cysteine proteases in Fasciola hepatica newly excysted juveniles using RNA interference reduces gut penetration","volume":"38","author":"Mcgonigle","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib338","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1146\/annurev.pathol.1.110304.100151","article-title":"Proteases in parasitic diseases","volume":"1","author":"Mckerrow","year":"2006","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/bs.apar.2024.07.002_bib339","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/bj2310047","article-title":"Proteinases from invasive larvae of the trematode parasite Schistosoma mansoni degrade connective-tissue and basement-membrane macromolecules","volume":"231","author":"Mckerrow","year":"1985","journal-title":"Biochem. J."},{"key":"10.1016\/bs.apar.2024.07.002_bib340","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.1016\/S0021-9258(19)83680-3","article-title":"Purification and characterization of an elastinolytic proteinase secreted by cercariae of Schistosoma mansoni","volume":"260","author":"Mckerrow","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib341","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.micinf.2011.11.012","article-title":"Fasciola hepatica virulence-associated cysteine peptidases: a systems biology perspective","volume":"14","author":"Mcveigh","year":"2012","journal-title":"Microbes Infect."},{"key":"10.1016\/bs.apar.2024.07.002_bib342","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.molbiopara.2018.02.001","article-title":"Fibrinogen and fibrin are novel substrates for Fasciola hepatica cathepsin L peptidases","volume":"221","author":"Mebius","year":"2018","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib343","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003781","article-title":"Interference with the host haemostatic system by schistosomes","volume":"9","author":"Mebius","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/bs.apar.2024.07.002_bib344","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2004.02.010","article-title":"Molecular cloning and analysis of stage and tissue-specific expression of cathepsin B encoding genes from Fasciola gigantica","volume":"136","author":"Meemon","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib345","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.exppara.2010.03.003","article-title":"Fasciola gigantica: histology of the digestive tract and the expression of cathepsin L","volume":"125","author":"Meemon","year":"2010","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib346","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.micpath.2017.06.006","article-title":"A review on epidemiology, global prevalence and economical losses of fasciolosis in ruminants","volume":"109","author":"Mehmood","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/bs.apar.2024.07.002_bib347","first-page":"193","article-title":"cDNA sequences of Schistosoma japonicum coding for two cathepsin B-like proteins and Sj32","volume":"45","author":"Merckelbach","year":"1994","journal-title":"Tropical Med. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib348","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0166-6851(95)00092-F","article-title":"Sequence, characterization and localization of a cysteine proteinase cathepsin L in Schistosoma mansoni","volume":"73","author":"Michel","year":"1995","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib349","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s00436-005-1347-1","article-title":"In vitro stimulation of penetration gland emptying by Trichobilharzia szidati and T. regenti (Schistosomatidae) cercariae. Quantitative collection and partial characterization of the products","volume":"96","author":"Mike\u0161","year":"2005","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0203490","article-title":"Evaluation of a set of refolded recombinant antigens for serodiagnosis of human fascioliasis","volume":"13","author":"Mirzadeh","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/bs.apar.2024.07.002_bib351","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.cbpc.2005.07.008","article-title":"Proteases in egg, miracidium and adult of Fasciola gigantica. Characterization of serine and cysteine proteases from adult","volume":"142","author":"Mohamed","year":"2005","journal-title":"Comp. Biochem. Physiol. Part B: Biochem. Mol. Biol."},{"key":"10.1016\/bs.apar.2024.07.002_bib352","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00436-017-5696-3","article-title":"Comparative assessment of recombinant and native immunogenic forms of Fasciola hepatica proteins for serodiagnosis of sheep fasciolosis","volume":"117","author":"Mokhtarian","year":"2018","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib353","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1186\/1756-3305-7-330","article-title":"Characterisation of a secretory serine protease inhibitor (SjB6) from Schistosoma japonicum","volume":"7","author":"Molehin","year":"2014","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib354","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1017\/S0031182014001061","article-title":"Functional characterization of SjB10, an intracellular serpin from Schistosoma japonicum","volume":"141","author":"Molehin","year":"2014","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib355","article-title":"Process development of Sj-p80: a low-cost transmission-blocking veterinary vaccine for asiatic schistosomiasis","volume":"11","author":"Molehin","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib356","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23042255","article-title":"Vaccines for human schistosomiasis: recent progress, new developments and future prospects","volume":"23","author":"Molehin","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/bs.apar.2024.07.002_bib357","doi-asserted-by":"crossref","first-page":"3175","DOI":"10.1007\/s00436-017-5634-4","article-title":"Cross-species prophylactic efficacy of Sm-p80-based vaccine and intracellular localization of Sm-p80\/Sm-p80 ortholog proteins during development in Schistosoma mansoni, Schistosoma japonicum, and Schistosoma haematobium","volume":"116","author":"Molehin","year":"2017","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib358","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184192","article-title":"Effects of proteasome inhibitor MG-132 on the parasite Schistosoma mansoni","volume":"12","author":"Morais","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/bs.apar.2024.07.002_bib359","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006870","article-title":"Schistosoma mansoni SmKI-1 serine protease inhibitor binds to elastase and impairs neutrophil function and inflammation","volume":"14","author":"Morais","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/bs.apar.2024.07.002_bib360","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.3389\/fimmu.2018.01762","article-title":"Schistosoma mansoni SmKI-1 or its C-terminal fragment induces partial protection against S. mansoni infection in mice","volume":"9","author":"Morais","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib361","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.molbiopara.2003.10.016","article-title":"The N-terminus moiety of the cystatin SmCys from Schistosoma mansoni regulates its inhibitory activity in vitro and in vivo","volume":"134","author":"Morales","year":"2004","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib362","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.gene.2004.05.017","article-title":"Genomic organization of the Schistosoma mansoni aspartic protease gene, a platyhelminth orthologue of mammalian lysosomal cathepsin D","volume":"338","author":"Morales","year":"2004","journal-title":"Gene"},{"key":"10.1016\/bs.apar.2024.07.002_bib363","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.molbiopara.2007.10.009","article-title":"RNA interference of Schistosoma mansoni cathepsin D, the apical enzyme of the hemoglobin proteolysis cascade","volume":"157","author":"Morales","year":"2008","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib364","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/14756360902888184","article-title":"Fluorobenzoyl dipeptidyl derivatives as inhibitors of the Fasciola hepatica cysteine protease cathepsin L1","volume":"25","author":"Moran","year":"2010","journal-title":"J. Enzyme Inhibition Med. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib365","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1053\/rvsc.1998.0270","article-title":"Immune responses of cattle to experimental anti-Fasciola hepatica vaccines","volume":"67","author":"Mulcahy","year":"1999","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/bs.apar.2024.07.002_bib366","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/S0264-410X(97)00289-2","article-title":"Correlation of specific antibody titre and avidity with protection in cattle immunized against Fasciola hepatica","volume":"16","author":"Mulcahy","year":"1998","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib367","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ijpara.2007.09.001","article-title":"CsCF-6, a novel cathepsin F-like cysteine protease for nutrient uptake of Clonorchis sinensis","volume":"38","author":"Na","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib368","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.exppara.2007.08.002","article-title":"The 26S proteasome in Schistosoma mansoni: bioinformatics analysis, developmental expression, and RNA interference (RNAi) studies","volume":"117","author":"Nabhan","year":"2007","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib369","first-page":"411","article-title":"Molecular expression of a cysteine proteinase of Clonorchis sinensis and its application to an enzyme-linked immunosorbent assay for immunodiagnosis of clonorchiasis","volume":"11","author":"Nagano","year":"2004","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib370","doi-asserted-by":"crossref","first-page":"13179","DOI":"10.1016\/S0021-9258(18)37688-9","article-title":"Cloning of the proteinase that facilitates infection by schistosome parasites","volume":"263","author":"Newport","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib371","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.exppara.2019.02.001","article-title":"Construction of a novel phage display antibody library against Fasciola hepatica, and generation of a single-chain variable fragment specific for F. hepatica cathepsin L1","volume":"198","author":"Norbury","year":"2019","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib372","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.vetpar.2018.05.008","article-title":"Intranasal delivery of a formulation containing stage-specific recombinant proteins of Fasciola hepatica cathepsin L5 and cathepsin B2 triggers an anti-fecundity effect and an adjuvant-mediated reduction in fluke burden in sheep","volume":"258","author":"Norbury","year":"2018","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib373","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1016\/j.biochi.2010.12.004","article-title":"Adult and juvenile Fasciola cathepsin L proteases: different enzymes for different roles","volume":"93","author":"Norbury","year":"2011","journal-title":"Biochimie"},{"key":"10.1016\/bs.apar.2024.07.002_bib374","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.biochi.2012.01.011","article-title":"Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference","volume":"94","author":"Norbury","year":"2012","journal-title":"Biochimie"},{"key":"10.1016\/bs.apar.2024.07.002_bib375","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1046\/j.1365-3024.2001.00414.x","article-title":"Immunogenicity of synthetic peptides from the Sm31 antigen (cathepsin B) of the Schistosoma mansoni adult worms","volume":"23","author":"Noya","year":"2001","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib376","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/nmeth.2182","article-title":"Global identification of peptidase specificity by multiplex substrate profiling","volume":"9","author":"O\u2019donoghue","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/bs.apar.2024.07.002_bib377","doi-asserted-by":"crossref","first-page":"749","DOI":"10.4269\/ajtmh.1999.60.749","article-title":"Short report: immunodiagnosis of human fascioliasis using recombinant Fasciola hepatica cathepsin L1 cysteine proteinase","volume":"60","author":"O\u2019neill","year":"1999","journal-title":"Am. J. Tropical Med. Hyg."},{"key":"10.1016\/bs.apar.2024.07.002_bib378","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1046\/j.1365-2567.2003.01706.x","article-title":"Inhibition of complement activation by recombinant Sh-CRIT-ed1 analogues","volume":"110","author":"Oh","year":"2003","journal-title":"Immunology"},{"key":"10.1016\/bs.apar.2024.07.002_bib379","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S1046-5928(02)00598-3","article-title":"Expression and purification of the anticomplementary peptide Sh-CRIT-ed1 (formerly Sh-TOR-ed1) as a tetramultimer in Escherichia coli","volume":"27","author":"Oh","year":"2003","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/bs.apar.2024.07.002_bib380","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1016\/j.vaccine.2019.04.067","article-title":"Moderate protection is induced by a chimeric protein composed of leucine aminopeptidase and cathepsin L1 against Fasciola hepatica challenge in sheep","volume":"37","author":"Ortega-Vargas","year":"2019","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib381","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1016\/j.vaccine.2004.10.042","article-title":"Establishment of Schistosoma japonicum calpain-specific mouse T cell hybridomas and identification of a T cell epitope that stimulates IFNgamma production","volume":"23","author":"Osada","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib382","doi-asserted-by":"crossref","first-page":"7192","DOI":"10.1021\/jm900849h","article-title":"Aza-peptidyl Michael acceptor and epoxide inhibitors--potent and selective inhibitors of Schistosoma mansoni and Ixodes ricinus legumains (asparaginyl endopeptidases)","volume":"52","author":"Ovat","year":"2009","journal-title":"J. Med. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib383","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.vetpar.2017.03.022","article-title":"Th1\/Th2 balance in the liver and hepatic lymph nodes of vaccinated and unvaccinated sheep during acute stages of infection with Fasciola hepatica","volume":"238","author":"Pacheco","year":"2017","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib384","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1007\/s00436-016-5053-y","article-title":"Molecular characterization of serine protease inhibitor isoform 3, SmSPI, from Schistosoma mansoni","volume":"115","author":"Pakchotanon","year":"2016","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib385","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/expr.2001.4634","article-title":"Paragonimus westermani: cloning of a cathepsin F-like cysteine proteinase from the adult worm","volume":"98","author":"Park","year":"2001","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib386","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0014-4894(03)00036-5","article-title":"Characterization and classification of five cysteine proteinases expressed by Paragonimus westermani adult worm","volume":"102","author":"Park","year":"2002","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib387","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbrc.2018.02.196","article-title":"Structural basis of the cystein protease inhibitor Clonorchis sinensis Stefin-1","volume":"498","author":"Park","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/bs.apar.2024.07.002_bib388","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1645\/0022-3395(2001)087[1454:CALSEO]2.0.CO;2","article-title":"Characterization and large-scale expression of the recombinant cysteine proteinase from adult Clonorchis sinensis","volume":"87","author":"Park","year":"2001","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib389","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.663041","article-title":"Immunomics-guided antigen discovery for praziquantel-induced vaccination in urogenital human schistosomiasis","volume":"12","author":"Pearson","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib390","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s00436-010-1956-1","article-title":"Molecular cloning and characterization of a gene encoding methionine aminopeptidase 2 of Schistosoma japonicum","volume":"107","author":"Peng","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib391","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00436-010-1752-y","article-title":"Molecular characterizations of an inhibitor of apoptosis from Schistosoma japonicum","volume":"106","author":"Peng","year":"2010","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib392","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.ejmech.2019.06.062","article-title":"Discovery and characterization of trypanocidal cysteine protease inhibitors from the \u2019malaria box\u2019","volume":"179","author":"Pereira","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib393","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/480824","article-title":"Transcriptional profile and structural conservation of SUMO-specific proteases in Schistosoma mansoni","volume":"2012","author":"Pereira","year":"2012","journal-title":"J. Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib394","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s13071-015-0957-4","article-title":"Ubiquitin-specific proteases are differentially expressed throughout the Schistosoma mansoni life cycle","volume":"8","author":"Pereira","year":"2015","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib395","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1007\/s00436-015-4484-1","article-title":"MJD and OTU deubiquitinating enzymes in Schistosoma mansoni","volume":"114","author":"Pereira","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib396","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/0074-0276130107","article-title":"Conservation and developmental expression of ubiquitin isopeptidases in Schistosoma mansoni","volume":"109","author":"Pereira","year":"2014","journal-title":"Mem\u00f3rias do Inst. Oswaldo Cruz"},{"key":"10.1016\/bs.apar.2024.07.002_bib397","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.605288","article-title":"Adjuvanted Schistosoma mansoni-cathepsin B with sulfated lactosyl archaeol archaeosomes or AddaVax provides protection in a pre-clinical schistosomiasis model","volume":"11","author":"Perera","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib398","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2022.104036","article-title":"A low dose adenovirus vectored vaccine expressing Schistosoma mansoni Cathepsin B protects from intestinal schistosomiasis in mice","volume":"80","author":"Perera","year":"2022","journal-title":"EBioMedicine"},{"key":"10.1016\/bs.apar.2024.07.002_bib399","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.tvjl.2009.07.004","article-title":"Pathological and parasitological protection in goats immunised with recombinant cathepsin L1 and challenged with Fasciola hepatica","volume":"185","author":"Perez-Ecija","year":"2010","journal-title":"Vet. J."},{"key":"10.1016\/bs.apar.2024.07.002_bib400","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1128\/IAI.67.4.1954-1961.1999","article-title":"Vaccination with cathepsin L proteinases and with leucine aminopeptidase induces high levels of protection against fascioliasis in sheep","volume":"67","author":"Piacenza","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/bs.apar.2024.07.002_bib401","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1017\/S0022149X00016151","article-title":"Proteinases secreted by Fasciola hepatica: time course of the inhibitory effect of serum from experimentally infected rabbits demonstrated by gelatin-substrate polyacrylamide gel electrophoresis","volume":"71","author":"Piacenza","year":"1997","journal-title":"J. Helminthol."},{"key":"10.1016\/bs.apar.2024.07.002_bib402","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0166-6851(95)02502-2","article-title":"Cloning and characterization of two genes encoding Schistosoma mansoni elastase","volume":"75","author":"Pierrot","year":"1995","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib403","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1017\/S0031182000067561","article-title":"Schistosoma mansoni elastase: an immune target regulated during the parasite life-cycle","volume":"113","author":"Pierrot","year":"1996","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib404","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000398","article-title":"Cathepsin F cysteine protease of the human liver fluke, Opisthorchis viverrini","volume":"3","author":"Pinlaor","year":"2009","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib405","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12860-020-00335-5","article-title":"Regulation of the Fasciola hepatica newly excysted juvenile cathepsin L3 (FhCL3) by its propeptide: a proposed \u2018clamp-like\u2019 mechanism of binding and inhibition","volume":"21","author":"Pritsch","year":"2020","journal-title":"BMC Mol. Cell Biol."},{"key":"10.1016\/bs.apar.2024.07.002_bib406","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.0141-9838.2001.00438.x","article-title":"Fasciola hepatica cathepsin L suppresses sheep lymphocyte proliferation in vitro and modulates surface CD4 expression on human and ovine T cells","volume":"24","author":"Prowse","year":"2002","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib407","doi-asserted-by":"crossref","first-page":"3095","DOI":"10.1007\/s00436-014-3975-9","article-title":"Systemic and local mucosal immune responses induced by orally delivered Bacillus subtilis spore expressing leucine aminopeptidase 2 of Clonorchis sinensis","volume":"113","author":"Qu","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib408","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.actatropica.2011.02.008","article-title":"Lack of protective efficacy in buffaloes vaccinated with Fasciola gigantica leucine aminopeptidase and peroxiredoxin recombinant proteins","volume":"118","author":"Raina","year":"2011","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib409","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.actatropica.2006.03.004","article-title":"Immuno-diagnosis of bubaline fasciolosis with Fasciola gigantica cathepsin-L and recombinant cathepsin L 1-D proteases","volume":"98","author":"Raina","year":"2006","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib410","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ijid.2017.10.024","article-title":"Kunitz-type protease inhibitor as a vaccine candidate against schistosomiasis mansoni","volume":"66","author":"Ranasinghe","year":"2018","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib411","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1186\/s13071-015-1022-z","article-title":"Functional expression of a novel Kunitz type protease inhibitor from the human blood fluke Schistosoma mansoni","volume":"8","author":"Ranasinghe","year":"2015","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib412","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1017\/S0031182015001328","article-title":"A novel coagulation inhibitor from Schistosoma japonicum","volume":"142","author":"Ranasinghe","year":"2015","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib413","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.pt.2016.12.013","article-title":"Protease inhibitors of parasitic flukes: emerging roles in parasite survival and immune defence","volume":"33","author":"Ranasinghe","year":"2017","journal-title":"Trends Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib414","doi-asserted-by":"crossref","first-page":"D624","DOI":"10.1093\/nar\/gkx1134","article-title":"The MEROPS database of proteolytic enzymes, their substrates and inhibitors in 2017 and a comparison with peptidases in the PANTHER database","volume":"46","author":"Rawlings","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib415","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2307\/3283679","article-title":"Cysteine proteinases from Schistosoma haematobium adult worms","volume":"78","author":"Rege","year":"1992","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib416","doi-asserted-by":"crossref","first-page":"2987","DOI":"10.1016\/j.vaccine.2004.12.007","article-title":"Fasciola hepatica procathepsin L3 protein expressed by a baculovirus recombinant can partly protect rats against fasciolosis","volume":"23","author":"Reszka","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib417","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.vaccine.2014.11.016","article-title":"Evaluation of the immune response and protective efficacy of Schistosoma mansoni Cathepsin B in mice using CpG dinucleotides as adjuvant","volume":"33","author":"Ricciardi","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib418","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s12879-016-1444-z","article-title":"A vaccine consisting of Schistosoma mansoni cathepsin B formulated in Montanide ISA 720 VG induces high level protection against murine schistosomiasis","volume":"16","author":"Ricciardi","year":"2016","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib419","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.3389\/fimmu.2018.01710","article-title":"Immune mechanisms involved in Schistosoma mansoni-Cathepsin B vaccine induced protection in mice","volume":"9","author":"Ricciardi","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib420","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.molbiopara.2009.05.002","article-title":"RNA interference targeting leucine aminopeptidase blocks hatching of Schistosoma mansoni eggs","volume":"167","author":"Rinaldi","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib421","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000260","article-title":"Development of functional genomic tools in trematodes: RNA interference and luciferase reporter gene activity in Fasciola hepatica","volume":"2","author":"Rinaldi","year":"2008","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib422","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1073\/pnas.90.8.3583","article-title":"Structure-based inhibitor design by using protein models for the development of antiparasitic agents","volume":"90","author":"Ring","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.apar.2024.07.002_bib423","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001012","article-title":"Collagenolytic activities of the major secreted cathepsin L peptidases involved in the virulence of the helminth pathogen, Fasciola hepatica","volume":"5","author":"Robinson","year":"2011","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib424","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1074\/mcp.M700560-MCP200","article-title":"Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors","volume":"7","author":"Robinson","year":"2008","journal-title":"Mol. Cell. Proteom."},{"key":"10.1016\/bs.apar.2024.07.002_bib425","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1432-1033.1997.t01-1-00373.x","article-title":"Functional expression of Fasciola hepatica cathepsin L1 in Saccharomyces cerevisiae","volume":"245","author":"Roche","year":"1997","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/bs.apar.2024.07.002_bib426","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0166-6851(98)00164-9","article-title":"The propeptide of Fasciola hepatica cathepsin L is a potent and selective inhibitor of the mature enzyme","volume":"98","author":"Roche","year":"1999","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib427","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171677","article-title":"Sm-p80-based schistosomiasis vaccine mediated epistatic interactions identified potential immune signatures for vaccine efficacy in mice and baboons","volume":"12","author":"Rojo","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/bs.apar.2024.07.002_bib428","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/BF00927089","article-title":"Isolation and some properties of an acid protease from Fasciola hepatica","volume":"61","author":"Rupova","year":"1979","journal-title":"Z. f\u00fcr Parasitenkunde"},{"key":"10.1016\/bs.apar.2024.07.002_bib429","first-page":"325","article-title":"Schistosoma mansoni and S. japonicum: decline of antibodies against diagnostic adult worm antigens (Sm31\/32) following praziquantel treatment of mice","volume":"42","author":"Ruppel","year":"1991","journal-title":"Tropical Med. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib430","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.biochi.2005.06.004","article-title":"Peptide synthesis by recombinant Fasciola hepatica cathepsin L1","volume":"88","author":"Ruth","year":"2006","journal-title":"Biochimie"},{"key":"10.1016\/bs.apar.2024.07.002_bib431","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1007\/s00436-020-06907-w","article-title":"Effectiveness of Fasciola gigantica excretory-secretory and recombinant cathepsin L antigens for rapid diagnosis of human fascioliasis using immunochromatographic devices","volume":"119","author":"Sadaow","year":"2020","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib432","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0166-6851(03)00194-4","article-title":"Functional expression and characterization of Schistosoma mansoni cathepsin B and its trans-activation by an endogenous asparaginyl endopeptidase","volume":"131","author":"Sajid","year":"2003","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib433","doi-asserted-by":"crossref","first-page":"24618","DOI":"10.1074\/jbc.M202364200","article-title":"Cercarial elastase is encoded by a functionally conserved gene family across multiple species of schistosomes","volume":"277","author":"Salter","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib434","doi-asserted-by":"crossref","first-page":"38667","DOI":"10.1074\/jbc.M006997200","article-title":"Schistosome invasion of human skin and degradation of dermal elastin are mediated by a single serine protease","volume":"275","author":"Salter","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib435","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.ijpara.2020.05.010","article-title":"Serpins in Fasciola hepatica: insights into host-parasite interactions","volume":"50","author":"Sanchez Di Maggio","year":"2020","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib436","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.actatropica.2013.06.013","article-title":"Molecular cloning, characterization and functional analysis of a novel juvenile-specific cathepsin L of Fasciola gigantica","volume":"128","author":"Sansri","year":"2013","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib437","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.vaccine.2015.02.010","article-title":"Protection against Fasciola gigantica infection in mice by vaccination with recombinant juvenile-specific cathepsin L","volume":"33","author":"Sansri","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib438","article-title":"Schistocins: Novel antimicrobial peptides encrypted in the Schistosoma mansoni Kunitz Inhibitor SmKI-1","volume":"1865","author":"Santos","year":"2021","journal-title":"Biochim. Biophys. Acta (BBA)\u2014Gen. Subj."},{"key":"10.1016\/bs.apar.2024.07.002_bib439","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2020.102222","article-title":"Seroprevalence of fasciolosis in Hokkaido sika deer (Cervus nippon yesoensis) from Hokkaido Prefecture, Japan revealed by ELISA using recombinant cathepsin L1","volume":"80","author":"Sato","year":"2021","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib440","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1021\/bi00180a020","article-title":"Role of the S\u2019 subsites in serine protease catalysis. Active-site mapping of rat chymotrypsin, rat trypsin, alpha-lytic protease, and cercarial protease from Schistosoma mansoni","volume":"33","author":"Schellenberger","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/bs.apar.2024.07.002_bib441","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.bbaexp.2004.11.004","article-title":"Organization and functional analysis of the Schistosoma mansoni cathepsin D-like aspartic protease gene promoter","volume":"1727","author":"Schulmeister","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/bs.apar.2024.07.002_bib442","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1383-5769(99)00021-5","article-title":"Characterisation and expression of a cDNA encoding the 80-kDa large subunit of Schistosoma japonicum calpain","volume":"48","author":"Scott","year":"2000","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib443","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24098165","article-title":"Molecular characterization of the interplay between Fasciola hepatica juveniles and laminin as a mechanism to adhere to and break through the host intestinal wall","volume":"24","author":"Serrat","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/bs.apar.2024.07.002_bib444","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.actatropica.2009.07.016","article-title":"Identification, expression and immunolocalization of cathepsin B3, a stage-specific antigen expressed by juvenile Fasciola gigantica","volume":"112","author":"Sethadavit","year":"2009","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib445","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2022.106519","article-title":"Characterization of aspartyl aminopeptidase from Schistosoma japonicum","volume":"232","author":"Shang","year":"2022","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib446","doi-asserted-by":"crossref","first-page":"3844","DOI":"10.1128\/IAI.71.7.3844-3851.2003","article-title":"Induction of protective immunity against Schistosoma mansoni via DNA priming and boosting with the large subunit of calpain (Sm-p80): adjuvant effects of granulocyte-macrophage colony-stimulating factor and interleukin-4","volume":"71","author":"Siddiqui","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/bs.apar.2024.07.002_bib447","doi-asserted-by":"crossref","first-page":"2882","DOI":"10.1016\/S0264-410X(03)00159-2","article-title":"Enhancement of Sm-p80 (large subunit of calpain) induced protective immunity against Schistosoma mansoni through co-delivery of interleukin-2 and interleukin-12 in a DNA vaccine formulation","volume":"21","author":"Siddiqui","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib448","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1051\/parasite\/2005121003","article-title":"Characterization of protective immunity induced against Schistosoma mansoni via DNA priming with the large subunit of calpain (Sm-p80) in the presence of genetic adjuvants","volume":"12","author":"Siddiqui","year":"2005","journal-title":"Parasite"},{"key":"10.1016\/bs.apar.2024.07.002_bib449","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.vaccine.2004.09.018","article-title":"Characterization of the immune response to DNA vaccination strategies for schistosomiasis candidate antigen, Sm-p80 in the baboon","volume":"23","author":"Siddiqui","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib450","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.pt.2016.10.010","article-title":"Sm-p80-based schistosomiasis vaccine: preparation for human clinical trials","volume":"33","author":"Siddiqui","year":"2017","journal-title":"Trends Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib451","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0925-4439(93)90087-H","article-title":"Characterization of Ca(2+)-dependent neutral protease (calpain) from human blood flukes, Schistosoma mansoni","volume":"1181","author":"Siddiqui","year":"1993","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/bs.apar.2024.07.002_bib452","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/nyas.13866","article-title":"Sm-p80-based vaccine trial in baboons: efficacy when mimicking natural conditions of chronic disease, praziquantel therapy, immunization, and Schistosoma mansoni re-encounter","volume":"1425","author":"Siddiqui","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/bs.apar.2024.07.002_bib453","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-5793(02)02270-6","article-title":"Exploring the subsite specificity of Schistosoma mansoni aspartyl hemoglobinase through comparative molecular modelling","volume":"514","author":"Silva","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/bs.apar.2024.07.002_bib454","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1590\/S0074-02762011000700013","article-title":"Evolutionary histories of expanded peptidase families in Schistosoma mansoni","volume":"106","author":"Silva","year":"2011","journal-title":"Mem\u00f3rias do Inst. Oswaldo Cruz"},{"key":"10.1016\/bs.apar.2024.07.002_bib455","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.3389\/fimmu.2020.02087","article-title":"A vaccine based on Kunitz-type molecule confers protection against Fasciola hepatica challenge by inducing IFN-gamma and antibody immune responses through IL-17A production","volume":"11","author":"Silvane","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib456","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.molbiopara.2007.04.003","article-title":"Single nucleotide polymorphisms identification in expressed genes of Schistosoma mansoni","volume":"154","author":"Simoes","year":"2007","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib457","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.molbiopara.2012.10.003","article-title":"Efficient inhibition of cathepsin B by a secreted type 1 cystatin of Fasciola gigantica","volume":"186","author":"Siricoon","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib458","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.biochi.2015.10.005","article-title":"Fasciola gigantica cathepsin B5 is an acidic endo- and exopeptidase of the immature and mature parasite","volume":"119","author":"Siricoon","year":"2015","journal-title":"Biochimie"},{"key":"10.1016\/bs.apar.2024.07.002_bib459","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0020-7519(03)00030-4","article-title":"Suppression of cathepsin B expression in Schistosoma mansoni by RNA interference","volume":"33","author":"Skelly","year":"2003","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib460","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1645\/0022-3395(2001)087[1218:SMPSCB]2.0.CO;2","article-title":"Schistosoma mansoni proteases Sm31 (cathepsin B) and Sm32 (legumain) are expressed in the cecum and protonephridia of cercariae","volume":"87","author":"Skelly","year":"2001","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib461","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-3024.1994.tb00356.x","article-title":"Neutralization of the activity of a Fasciola hepatica cathepsin L proteinase by anti-cathepsin L antibodies","volume":"16","author":"Smith","year":"1994","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib462","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0166-6851(94)90091-4","article-title":"Adult Schistosoma mansoni express cathepsin L proteinase activity","volume":"67","author":"Smith","year":"1994","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib463","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/0020-7519(93)90117-H","article-title":"Fasciola hepatica: a secreted cathepsin L-like proteinase cleaves host immunoglobulin","volume":"23","author":"Smith","year":"1993","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib464","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0166-6851(93)90171-S","article-title":"Purification of a cathepsin L-like proteinase secreted by adult Fasciola hepatica","volume":"62","author":"Smith","year":"1993","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib465","doi-asserted-by":"crossref","first-page":"20657","DOI":"10.1038\/s41598-020-77687-7","article-title":"An atypical and functionally diverse family of Kunitz-type cysteine\/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica","volume":"10","author":"Smith","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.apar.2024.07.002_bib466","doi-asserted-by":"crossref","first-page":"19220","DOI":"10.1074\/jbc.M116.724344","article-title":"Unexpected activity of a novel Kunitz-type inhibitor: inhibition of cysteine proteases but not serine proteases","volume":"291","author":"Smith","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib467","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1006\/expr.2001.4601","article-title":"Fasciola: kinetics and quality of humoral responses to fatty acid binding protein and cathepsin l following delivery as DNA vaccines in mice","volume":"97","author":"Smooker","year":"2001","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib468","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1110\/ps.9.12.2567","article-title":"A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica","volume":"9","author":"Smooker","year":"2000","journal-title":"Protein Sci."},{"key":"10.1016\/bs.apar.2024.07.002_bib469","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007070","article-title":"A secreted schistosome cathepsin B1 cysteine protease and acute schistosome infection induce a transient T helper 17 response","volume":"13","author":"Soloviova","year":"2019","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib470","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0305-0491(90)90129-H","article-title":"Clonorchis sinensis: purification and characterization of a cysteine proteinase from adult worms","volume":"97","author":"Song","year":"1990","journal-title":"Comp. Biochem. Physiol. Part B: Biochem. Mol. Biol."},{"key":"10.1016\/bs.apar.2024.07.002_bib471","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.parint.2008.02.004","article-title":"Identification and characterization of Paragonimus westermani leucine aminopeptidase","volume":"57","author":"Song","year":"2008","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib472","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1021\/acsinfecdis.3c00589","article-title":"Nature-inspired gallinamides are potent antischistosomal agents: inhibition of the cathepsin B1 protease target and binding mode analysis","volume":"10","author":"Spiwokov\u00e1","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib473","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.parint.2011.05.009","article-title":"Evaluation of liver fluke recombinant cathepsin B-1 protease as a serodiagnostic antigen for human opisthorchiasis","volume":"61","author":"Sripa","year":"2012","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib474","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s13071-024-06285-7","article-title":"Multi-epitope protein production and its application in the diagnosis of opisthorchiasis","volume":"17","author":"Sripa","year":"2024","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib475","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1111\/j.1462-5822.2010.01433.x","article-title":"Secreted cysteine proteases of the carcinogenic liver fluke, Opisthorchis viverrini: regulation of cathepsin F activation by autocatalysis and trans-processing by cathepsin B","volume":"12","author":"Sripa","year":"2010","journal-title":"Cell. Microbiol."},{"key":"10.1016\/bs.apar.2024.07.002_bib476","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.parint.2011.04.003","article-title":"RNA interference targeting cathepsin B of the carcinogenic liver fluke, Opisthorchis viverrini","volume":"60","author":"Sripa","year":"2011","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib477","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.vetpar.2005.10.016","article-title":"Cathepsin L cysteine proteinase in the diagnosis of bovine Fasciola gigantica infection","volume":"135","author":"Sriveny","year":"2006","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib478","doi-asserted-by":"crossref","first-page":"9896","DOI":"10.1074\/jbc.M708521200","article-title":"Structural and functional relationships in the virulence-associated cathepsin L proteases of the parasitic liver fluke, Fasciola hepatica","volume":"283","author":"Stack","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib479","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jim.2005.07.019","article-title":"De-glycosylation of Pichia pastoris-produced Schistosoma mansoni cathepsin B eliminates non-specific reactivity with IgG in normal human serum","volume":"304","author":"Stack","year":"2005","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/bs.apar.2024.07.002_bib480","doi-asserted-by":"crossref","first-page":"16532","DOI":"10.1074\/jbc.M611501200","volume":"282","author":"Stack","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib481","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000850","article-title":"RNA interference in Schistosoma mansoni schistosomula: selectivity, sensitivity and operation for larger-scale screening","volume":"4","author":"\u0160tefani\u0107","year":"2010","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib482","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2021.102311","article-title":"Enzyme-linked immunosorbent assay (ELISA) using recombinant Fasciola cathepsin L1 for the diagnosis of human fasciolosis caused by Fasciola hepatica\/gigantica hybrid type","volume":"82","author":"Sugiyama","year":"2021","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib483","article-title":"Fasciola gigantica cathepsin L1H: high sensitivity and specificity of immunochromatographic strip test for antibody detection","volume":"8","author":"Suksomboon","year":"2023","journal-title":"Tropical Med. Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib484","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-3024.2009.01152.x","article-title":"Detection of the Sm31 antigen in sera of Schistosoma mansoni- infected patients from a low endemic area","volume":"32","author":"Sulbaran","year":"2010","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib485","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.biocel.2008.10.013","article-title":"Ov-APR-1, an aspartic protease from the carcinogenic liver fluke, Opisthorchis viverrini: functional expression, immunolocalization and subsite specificity","volume":"41","author":"Suttiprapa","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/bs.apar.2024.07.002_bib486","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/bs.apar.2018.06.002","article-title":"Opisthorchis viverrini proteome and host-parasite interactions","volume":"102","author":"Suttiprapa","year":"2018","journal-title":"Adv. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib487","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2019.102050","article-title":"Identification, recombinant protein production, and functional analysis of a M60-like metallopeptidase, secreted by the liver fluke Opisthorchis viverrini","volume":"75","author":"Ta","year":"2020","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib488","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3390\/vaccines8040682","article-title":"Specific antibodies and arachidonic acid mediate the protection induced by the Schistosoma mansoni cysteine peptidase-based vaccine in mice","volume":"8","author":"Tallima","year":"2020","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/bs.apar.2024.07.002_bib489","doi-asserted-by":"crossref","first-page":"6977","DOI":"10.1016\/j.vaccine.2017.10.069","article-title":"Protection against Schistosoma haematobium infection in hamsters by immunization with Schistosoma mansoni gut-derived cysteine peptidases, SmCB1 and SmCL3","volume":"35","author":"Tallima","year":"2017","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib490","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3389\/fimmu.2015.00130","article-title":"Induction of protective immune responses against Schistosomiasis haematobium in hamsters and mice using cysteine peptidase-based vaccine","volume":"6","author":"Tallima","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib491","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005443","article-title":"Protective immune responses against Schistosoma mansoni infection by immunization with functionally active gut-derived cysteine peptidases alone and in combination with glyceraldehyde 3-phosphate dehydrogenase","volume":"11","author":"Tallima","year":"2017","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib492","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2021.102346","article-title":"Potential of antibody test using Schistosoma mansoni recombinant serpin and RP26 to detect light-intensity infections in endemic areas","volume":"83","author":"Tanaka","year":"2021","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib493","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004021","article-title":"Species-specific serological detection for schistosomiasis by serine protease inhibitor (SERPIN) in multiplex assay","volume":"9","author":"Tanigawa","year":"2015","journal-title":"PLoS Neglected Tropical Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib494","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1017\/S0031182007003435","article-title":"Evaluation of immunoglobulin G4 subclass antibody in a peptide-based enzyme-linked immunosorbent assay for the serodiagnosis of human fascioliasis","volume":"134","author":"Tantrawatpan","year":"2007","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib495","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.molbiopara.2009.04.010","article-title":"Type I cystatin (stefin) is a major component of Fasciola gigantica excretion\/secretion product","volume":"167","author":"Tarasuk","year":"2009","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib496","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1007\/s00018-010-0345-3","article-title":"Vector-based RNA interference of cathepsin B1 in Schistosoma mansoni","volume":"67","author":"Tchoubrieva","year":"2010","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/bs.apar.2024.07.002_bib497","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.parint.2015.10.011","article-title":"Chicken IgY-based coproantigen capture ELISA for diagnosis of human opisthorchiasis","volume":"66","author":"Teimoori","year":"2017","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib498","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1007\/s00436-015-4703-9","article-title":"Immunodiagnosis of opisthorchiasis using parasite cathepsin F","volume":"114","author":"Teimoori","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib499","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2020.105355","article-title":"Partial protection with a chimeric tetraspanin-leucine aminopeptidase subunit vaccine against Opisthorchis viverrini infection in hamsters","volume":"204","author":"Thi Phung","year":"2020","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib500","doi-asserted-by":"crossref","first-page":"6753","DOI":"10.1016\/j.vaccine.2012.09.026","article-title":"Role of antibody dependent cell mediated cytotoxicity (ADCC) in Sm-p80-mediated protection against Schistosoma mansoni","volume":"30","author":"Torben","year":"2012","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib501","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1016\/j.vaccine.2011.01.040","article-title":"Role of antibodies in Sm-p80-mediated protection against Schistosoma mansoni challenge infection in murine and nonhuman primate models","volume":"29","author":"Torben","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib502","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s13071-021-04773-8","article-title":"Spatial expression pattern of serine proteases in the blood fluke Schistosoma mansoni determined by fluorescence RNA in situ hybridization","volume":"14","author":"Ulrychov\u00e1","year":"2021","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib503","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0165-2478(03)00113-5","article-title":"Immunological similarity between Schistosoma and bovine cathepsin D","volume":"89","author":"Valdivieso","year":"2003","journal-title":"Immunol. Lett."},{"key":"10.1016\/bs.apar.2024.07.002_bib504","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.vetpar.2011.07.032","article-title":"Development of cathepsin-L cysteine proteinase based Dot-enzyme-linked immunosorbent assay for the diagnosis of Fasciola gigantica infection in buffaloes","volume":"183","author":"Varghese","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib505","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1017\/S0031182001007521","article-title":"Schistosoma japonicum cathepsin D aspartic protease cleaves human IgG and other serum components","volume":"122","author":"Verity","year":"2001","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib506","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1016\/S0020-7519(99)00126-5","article-title":"Developmental expression of cathepsin D aspartic protease in Schistosoma japonicum","volume":"29","author":"Verity","year":"1999","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib507","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1046\/j.1365-3024.2001.00369.x","article-title":"Vaccine efficacy of recombinant cathepsin D aspartic protease from Schistosoma japonicum","volume":"23","author":"Verity","year":"2001","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib508","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1046\/j.1365-3024.2002.00475.x","article-title":"Cellular responses to Schistosoma japonicum cathepsin D aspartic protease","volume":"24","author":"Verity","year":"2002","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib509","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1365-3083.1986.tb02165.x","article-title":"Role of serine proteases of Schistosoma mansoni in the regulation of IgE synthesis","volume":"24","author":"Verwaerde","year":"1986","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib510","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1365-3083.1988.tb02318.x","article-title":"Properties of serine proteases of Schistosoma mansoni schistosomula involved in the regulation of IgE synthesis","volume":"27","author":"Verwaerde","year":"1988","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib511","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2021.104859","article-title":"Vaccination with cathepsin L mimotopes of Fasciola hepatica in goats reduces worm burden, morphometric measurements, and reproductive structures","volume":"155","author":"Villa-Mancera","year":"2021","journal-title":"Microb. Pathog."},{"key":"10.1016\/bs.apar.2024.07.002_bib512","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ijpara.2021.12.003","article-title":"Differential proteomic analysis of laser-microdissected penetration glands of avian schistosome cercariae with a focus on proteins involved in host invasion","volume":"52","author":"Vondr\u00e1\u010dek","year":"2022","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib513","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2020.109321","article-title":"Differences in the antibody response to adult Fasciola hepatica excretory\/secretory products in experimentally and naturally infected cattle and sheep","volume":"289","author":"Walsh","year":"2021","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib514","doi-asserted-by":"crossref","first-page":"12912","DOI":"10.1038\/s41598-017-13141-5","article-title":"The human blood parasite Schistosoma mansoni expresses extracellular tegumental calpains that cleave the blood clotting protein fibronectin","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.apar.2024.07.002_bib515","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13071-018-2704-0","article-title":"The blood fluke Schistosoma mansoni cleaves the coagulation protein high molecular weight kininogen (HK) but does not generate the vasodilator bradykinin","volume":"11","author":"Wang","year":"2018","journal-title":"Parasit. Vectors"},{"key":"10.1016\/bs.apar.2024.07.002_bib516","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.gene.2015.01.020","article-title":"Comparative genomic analysis of aspartic proteases in eight parasitic platyhelminths: insights into functions and evolution","volume":"559","author":"Wang","year":"2015","journal-title":"Gene"},{"key":"10.1016\/bs.apar.2024.07.002_bib517","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1016\/j.bmc.2019.05.014","article-title":"Highly tunable thiosulfonates as a novel class of cysteine protease inhibitors with anti-parasitic activity against Schistosoma mansoni","volume":"27","author":"Ward","year":"2019","journal-title":"Bioorgan. Med. Chem."},{"key":"10.1016\/bs.apar.2024.07.002_bib518","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0166-6851(96)02703-X","article-title":"Cysteine protease inhibitors block schistosome hemoglobin degradation in vitro and decrease worm burden and egg production in vivo","volume":"81","author":"Wasilewski","year":"1996","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib519","doi-asserted-by":"crossref","first-page":"24725","DOI":"10.1038\/srep24725","article-title":"A protease-based biosensor for the detection of schistosome cercariae","volume":"6","author":"Webb","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.apar.2024.07.002_bib520","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1017\/S0031182022000403","article-title":"Immunolocalization and functional analysis of Opisthorchis viverrini-M60-like-1 metallopeptidase in animal models","volume":"149","author":"Wendo","year":"2022","journal-title":"Parasitology"},{"key":"10.1016\/bs.apar.2024.07.002_bib521","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.vetpar.2018.04.001","article-title":"Sex and vaccination: insights from female rats vaccinated with juvenile-specific proteases from Fasciola hepatica","volume":"255","author":"Wesolowska","year":"2018","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib522","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.vetpar.2017.12.007","article-title":"Vaccination against Fasciola hepatica using cathepsin L3 and B3 proteases delivered alone or in combination","volume":"250","author":"Wesolowska","year":"2018","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib523","doi-asserted-by":"crossref","first-page":"13092","DOI":"10.1038\/s41598-018-31272-1","article-title":"Predictions of novel Schistosoma mansoni\u2014human protein interactions consistent with experimental data","volume":"8","author":"White Bear","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.apar.2024.07.002_bib524","unstructured":"WHO, 2023. Who fact sheet: Schistosomiasis [Online]. Available: www.who.int\/news-room\/fact-sheets\/detail\/schistosomiasis."},{"key":"10.1016\/bs.apar.2024.07.002_bib525","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1042\/bj2990781","article-title":"The secreted cathepsin L-like proteinases of the trematode, Fasciola hepatica, contain 3-hydroxyproline residues","volume":"299","author":"Wijffels","year":"1994","journal-title":"Biochem. J."},{"key":"10.1016\/bs.apar.2024.07.002_bib526","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1006\/expr.1994.1014","article-title":"Vaccination of sheep with purified cysteine proteinases of Fasciola hepatica decreases worm fecundity","volume":"78","author":"Wijffels","year":"1994","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib527","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1006\/expr.1998.4234","article-title":"Fasciola hepatica: characterization and cloning of the major cathepsin B protease secreted by newly excysted juvenile liver fluke","volume":"88","author":"Wilson","year":"1998","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib528","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.ijpara.2005.02.002","article-title":"Biolistic transformation of Schistosoma mansoni with 5\u2019 flanking regions of two peptidase genes promotes tissue-specific expression","volume":"35","author":"Wippersteg","year":"2005","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib529","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0167-4838(97)00019-8","article-title":"Schistosomes express two forms of cathepsin D","volume":"1338","author":"Wong","year":"1997","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/bs.apar.2024.07.002_bib530","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00436-014-4170-8","article-title":"Monoclonal antibody against recombinant Fasciola gigantica cathepsin L1H could detect juvenile and adult cathepsin Ls of Fasciola gigantica","volume":"114","author":"Wongwairot","year":"2015","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib531","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.617461","article-title":"Schistosoma japonicum cystatin alleviates sepsis through activating regulatory macrophages","volume":"11","author":"Xie","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/bs.apar.2024.07.002_bib532","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2307\/3281498","article-title":"Leucine aminopeptidase and hatching of Schistosoma mansoni eggs","volume":"72","author":"Xu","year":"1986","journal-title":"J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib533","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0014-4894(90)90093-R","article-title":"Schistosoma mansoni: purification and characterization of a membrane-associated leucine aminopeptidase","volume":"70","author":"Xu","year":"1990","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib534","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00436-005-1466-8","article-title":"Fasciola gigantica cathepsin-L cysteine proteinase in the detection of early experimental fasciolosis in ruminants","volume":"97","author":"Yadav","year":"2005","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib535","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/j.1432-1033.1995.490_2.x","article-title":"Purification and characterization of acid cysteine protease from metacercariae of the mammalian trematode parasite Paragonimus westermani","volume":"233","author":"Yamakami","year":"1995","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/bs.apar.2024.07.002_bib536","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0020-7519(02)00057-7","article-title":"Characterisation and expression of the Fasciola gigantica cathepsin L gene","volume":"32","author":"Yamasaki","year":"2002","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib537","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.vetpar.2005.04.038","article-title":"Characterization of a novel vaccine candidate and serine proteinase inhibitor from Schistosoma japonicum (Sj serpin)","volume":"131","author":"Yan","year":"2005","journal-title":"Vet. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib538","article-title":"Therapeutic effect of Schistosoma japonicum cystatin on atherosclerotic renal damage","volume":"9","author":"Yang","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/bs.apar.2024.07.002_bib539","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0264-410X(00)00165-1","article-title":"Multi-epitope schistosome vaccine candidates tested for protective immunogenicity in mice","volume":"19","author":"Yang","year":"2000","journal-title":"Vaccine"},{"key":"10.1016\/bs.apar.2024.07.002_bib540","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1007\/s00436-014-4064-9","article-title":"Cloning, expression and characterisation of a type II cystatin from Schistosoma japonicum, which could regulate macrophage activation","volume":"113","author":"Yang","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib541","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00436-009-1654-z","article-title":"Molecular cloning and characterization of a novel serpin gene of Clonorchis sinensis, highly expressed in the stage of metacercaria","volume":"106","author":"Yang","year":"2009","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib542","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1179\/2047773214Y.0000000138","article-title":"Comparison of two serpins of Clonorchis sinensis by bioinformatics, expression, and localization in metacercaria","volume":"108","author":"Yang","year":"2014","journal-title":"Pathog. Glob. Health"},{"key":"10.1016\/bs.apar.2024.07.002_bib543","doi-asserted-by":"crossref","DOI":"10.1128\/cmr.00241-21","article-title":"The mRNA vaccine technology era and the future control of parasitic infections","volume":"36","author":"You","year":"2023","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/bs.apar.2024.07.002_bib544","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1128\/CDLI.7.6.932-939.2000","article-title":"Structural and immunological characteristics of a 28-kilodalton cruzipain-like cysteine protease of Paragonimus westermani expressed in the definitive host stage","volume":"7","author":"Yun","year":"2000","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib545","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123996","article-title":"Novel non-peptide inhibitors against SmCL1 of Schistosoma mansoni: in silico elucidation, implications and evaluation via knowledge based drug discovery","volume":"10","author":"Zafar","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/bs.apar.2024.07.002_bib546","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jcpa.2012.08.007","article-title":"Early and late peritoneal and hepatic changes in goats immunized with recombinant cathepsin L1 and infected with Fasciola hepatica","volume":"148","author":"Zafra","year":"2013","journal-title":"J. Comp. Pathol."},{"key":"10.1016\/bs.apar.2024.07.002_bib547","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.molbiopara.2013.06.001","article-title":"Characterization and differential expression of cathepsin L3 alleles from Fasciola hepatica","volume":"190","author":"Zawistowska-Deniziak","year":"2013","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib548","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0014-4894(88)90071-9","article-title":"Schistosoma mansoni: expression and role of cysteine proteinases in developing schistosomula","volume":"67","author":"Zerda","year":"1988","journal-title":"Exp. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib549","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3347\/kjp.2022.60.2.117","article-title":"Molecular characteristics and potent immunomodulatory activity of Fasciola hepatica cystatin","volume":"60","author":"Zhang","year":"2022","journal-title":"Korean J. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib550","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S1383-5769(99)00024-0","article-title":"Cloning and molecular characterization of calpain, a calcium-activated neutral proteinase, from different strains of Schistosoma japonicum","volume":"48","author":"Zhang","year":"2000","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib551","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1128\/IAI.69.1.386-391.2001","article-title":"Vaccination with calpain induces a Th1-biased protective immune response against Schistosoma japonicum","volume":"69","author":"Zhang","year":"2001","journal-title":"Infect. Immun."},{"key":"10.1016\/bs.apar.2024.07.002_bib552","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.actatropica.2018.07.009","article-title":"Enzyme activity of Schistosoma japonicum cercarial elastase SjCE-2b ascertained by in vitro refolded recombinant protein","volume":"187","author":"Zhang","year":"2018","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib553","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1007\/s00436-014-3879-8","article-title":"Longevity of Sm-p80-specific antibody responses following vaccination with Sm-p80 vaccine in mice and baboons and transplacental transfer of Sm-p80-specific antibodies in a baboon","volume":"113","author":"Zhang","year":"2014","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib554","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1136\/jim-2018-000786","article-title":"Schistosoma mansoni antigen Sm-p80: prophylactic efficacy using TLR4 agonist vaccine adjuvant glucopyranosyl lipid A-Alum in murine and non-human primate models","volume":"66","author":"Zhang","year":"2018","journal-title":"J. Investig. Med."},{"key":"10.1016\/bs.apar.2024.07.002_bib555","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1086\/651147","article-title":"Sm-p80-based DNA vaccine provides baboons with levels of protection against Schistosoma mansoni infection comparable to those achieved by the irradiated cercarial vaccine","volume":"201","author":"Zhang","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/bs.apar.2024.07.002_bib556","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1365-3024.2009.01181.x","article-title":"Sm-p80-based DNA vaccine made in a human use approved vector VR1020 protects against challenge infection with Schistosoma mansoni in mouse","volume":"32","author":"Zhang","year":"2010","journal-title":"Parasite Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib557","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.actatropica.2011.01.010","article-title":"Schistosoma mansoni antigen Sm-p80: Prophylactic efficacy of a vaccine formulated in human approved plasmid vector and adjuvant (VR 1020 and alum)","volume":"118","author":"Zhang","year":"2011","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.apar.2024.07.002_bib558","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.3389\/fimmu.2020.01246","article-title":"Fifteen years of Sm-p80-based vaccine trials in nonhuman primates: antibodies from vaccinated baboons confer protection in vivo and in vitro from Schistosoma mansoni and identification of putative correlative markers of protection","volume":"11","author":"Zhang","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.apar.2024.07.002_bib559","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/nyas.13942","article-title":"Sm-p80-based schistosomiasis vaccine: double-blind preclinical trial in baboons demonstrates comprehensive prophylactic and parasite transmission-blocking efficacy","volume":"1425","author":"Zhang","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/bs.apar.2024.07.002_bib560","first-page":"163","article-title":"Antibody responses to leucine aminopeptidase in Schistosoma japonicum infection","volume":"23","author":"Zhang","year":"2011","journal-title":"Zhongguo Xue Xi Chong Bing. Fang. Zhi Za Zhi"},{"key":"10.1016\/bs.apar.2024.07.002_bib561","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.parint.2018.04.002","article-title":"Isolation and characterization of a novel serine protease inhibitor, SjSPI, from Schistosoma japonicum","volume":"67","author":"Zhang","year":"2018","journal-title":"Parasitol. Int."},{"key":"10.1016\/bs.apar.2024.07.002_bib562","doi-asserted-by":"crossref","DOI":"10.1016\/j.molbiopara.2019.111220","article-title":"A membrane-associated metalloprotease of Schistosoma japonicum structurally related to the FACE-1\/Ste24p protease family","volume":"233","author":"Zhang","year":"2019","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/bs.apar.2024.07.002_bib563","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s00436-012-3264-4","volume":"112","author":"Zheng","year":"2013","journal-title":"Parasitol. Res."},{"key":"10.1016\/bs.apar.2024.07.002_bib564","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008810","article-title":"Schistosoma japonicum cathepsin B2 (SjCB2) facilitates parasite invasion through the skin","volume":"14","author":"Zhu","year":"2020","journal-title":"PLoS Neglected Tropical Dis."}],"container-title":["Advances in Parasitology","Unveiling the Proteolytic Networks of Parasites"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065308X24000356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0065308X24000356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T15:06:10Z","timestamp":1729609570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0065308X24000356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9780443223303"],"references-count":564,"URL":"https:\/\/doi.org\/10.1016\/bs.apar.2024.07.002","relation":{},"ISSN":["0065-308X"],"issn-type":[{"type":"print","value":"0065-308X"}],"subject":[],"published":{"date-parts":[[2024]]}}}