{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:17:01Z","timestamp":1790957821960,"version":"4.1.0"},"reference-count":98,"publisher":"Elsevier","isbn-type":[{"value":"9780128220870","type":"print"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1016\/bs.apcsb.2020.09.002","type":"book-chapter","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T22:36:12Z","timestamp":1608330972000},"page":"133-162","source":"Crossref","is-referenced-by-count":32,"title":["The role of transferrins and iron-related proteins in brain iron transport: applications to neurological diseases"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.apcsb.2020.09.002_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2019\/4609702","article-title":"Iron redox Chemistry and implications in the Parkinson\u2019s disease brain","volume":"2019","author":"Abeyawardhane","year":"2019","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"8","key":"10.1016\/bs.apcsb.2020.09.002_bib2","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s00775-019-01731-9","article-title":"Redox active metals in\u00a0neurodegenerative diseases","volume":"24","author":"Acevedo","year":"2019","journal-title":"JBIC Journal of Biological Inorganic Chemistry"},{"issue":"2","key":"10.1016\/bs.apcsb.2020.09.002_bib3","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1523\/JNEUROSCI.1907-15.2016","article-title":"In vivo MRI mapping of brain iron deposition across the adult lifespan","volume":"36","author":"Acosta-Cabronero","year":"2016","journal-title":"Journal of Neuroscience"},{"issue":"8","key":"10.1016\/bs.apcsb.2020.09.002_bib4","doi-asserted-by":"crossref","first-page":"6027","DOI":"10.1074\/jbc.M210349200","article-title":"The position of arginine 124 controls the rate of iron release from the N-lobe of human serum transferrin: A structural study","volume":"278","author":"Adams","year":"2003","journal-title":"Journal of Biological Chemistry"},{"issue":"41","key":"10.1016\/bs.apcsb.2020.09.002_bib5","doi-asserted-by":"crossref","first-page":"14612","DOI":"10.1039\/C8DT02915F","article-title":"Incorporation of transuranium elements: Coordination of Cm( iii ) to human serum transferrin","volume":"47","author":"Adam","year":"2018","journal-title":"Dalton Transactions"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.freeradbiomed.2018.04.002","article-title":"Brain mitochondrial iron accumulates in Huntington\u2019s disease, mediates mitochondrial dysfunction, and can be removed pharmacologically","volume":"120","author":"Agrawal","year":"2018","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib7","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fnins.2019.00181","article-title":"Low cerebrospinal fluid levels of melanotransferrin are associated with conversion of mild cognitively impaired subjects to Alzheimer\u2019s disease","volume":"13","author":"Ashraf","year":"2019","journal-title":"Frontiers in Neuroscience"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fnagi.2018.00065","article-title":"The aging of iron man","volume":"10","author":"Ashraf","year":"2018","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"5","key":"10.1016\/bs.apcsb.2020.09.002_bib9","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1136\/jnnp-2017-316551","article-title":"Evidence that iron accelerates Alzheimer\u2019s pathology: A CSF biomarker study","volume":"89","author":"Ayton","year":"2018","journal-title":"Journal of Neurology, Neurosurgery & Psychiatry"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib10","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1093\/brain\/awx137","article-title":"Cerebral quantitative susceptibility mapping predicts amyloid-b-related cognitive decline","volume":"140","author":"Ayton","year":"2017","journal-title":"Brain"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2019.12.011","article-title":"Molecular targets and therapeutic interventions for iron induced neurodegeneration","volume":"156","author":"Bagwe-Parab","year":"2020","journal-title":"Brain Research Bulletin"},{"issue":"4","key":"10.1016\/bs.apcsb.2020.09.002_bib12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.chembiol.2020.03.014","article-title":"Achieving life through death: Redox Biology of lipid peroxidation in ferroptosis","volume":"27","author":"Bay\u0131r","year":"2020","journal-title":"Cell Chemical Biology"},{"issue":"5","key":"10.1016\/bs.apcsb.2020.09.002_bib13","doi-asserted-by":"crossref","first-page":"789","DOI":"10.3174\/ajnr.A4617","article-title":"Quantitative susceptibility mapping suggests altered brain iron in premanifest Huntington disease","volume":"37","author":"van Bergen","year":"2016","journal-title":"American Journal of Neuroradiology"},{"issue":"8","key":"10.1016\/bs.apcsb.2020.09.002_bib14","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1021\/bi9824543","article-title":"X-ray crystallography and mass spectroscopy reveal that the N-lobe of human transferrin expressed in Pichia pastoris is folded correctly but is glycosylated on serine-32 \u2020 , \u2021","volume":"38","author":"Bewley","year":"1999","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/bs.apcsb.2020.09.002_bib15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s10534-018-0087-5","article-title":"The ferroportin-ceruloplasmin system and the mammalian iron homeostasis machine: Regulatory pathways and the role of lactoferrin","volume":"31","author":"Bonaccorsi di Patti","year":"2018","journal-title":"Biometals"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neurobiolaging.2016.09.005","article-title":"In vivo assessment of iron content of the cerebral cortex in healthy aging using 7-Tesla T2\u2217-weighted phase imaging","volume":"53","author":"Buijs","year":"2017","journal-title":"Neurobiology of Aging"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib17","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.biocel.2019.02.009","article-title":"Endocytic iron trafficking and mitochondria in Parkinson\u2019s disease","volume":"110","author":"Cerri","year":"2019","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib18","series-title":"Brain iron metabolism and CNS diseases","author":"Chang","year":"2019"},{"issue":"3","key":"10.1016\/bs.apcsb.2020.09.002_bib19","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12781","article-title":"The role of astrocytes in oxidative stress of central nervous system: A mixed blessing","volume":"53","author":"Chen","year":"2020","journal-title":"Cell Proliferation"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3389\/fnins.2019.00085","article-title":"Deciphering the iron side of stroke: Neurodegeneration at the crossroads between iron dyshomeostasis, excitotoxicity, and ferroptosis","volume":"13","author":"DeGregorio-Rocasolano","year":"2019","journal-title":"Frontiers in Neuroscience"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib21","doi-asserted-by":"crossref","first-page":"104607","DOI":"10.1016\/j.neuint.2019.104607","article-title":"Iron chelators inhibit amyloid-\u03b2-induced production of lipocalin 2 in cultured astrocytes","volume":"132","author":"Dekens","year":"2020","journal-title":"Neurochemistry International"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib22","article-title":"Cerebrospinal fluid ceruloplasmin levels predict cognitive decline and brain atrophy in people with underlying \u03b2-amyloid pathology","volume":"7","author":"Diouf","year":"2020","journal-title":"Neurobiology of Disease"},{"issue":"11","key":"10.1016\/bs.apcsb.2020.09.002_bib23","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1074\/jbc.RA118.005142","article-title":"Fluorescence resonance energy transfer links membrane ferroportin, hephaestin but not ferroportin, amyloid precursor protein complex with iron efflux","volume":"294","author":"Dlouhy","year":"2019","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/bs.apcsb.2020.09.002_bib24","doi-asserted-by":"crossref","first-page":"111","DOI":"10.19261\/cjm.2018.482","article-title":"Structural aspects of lactoferrin and serum transferrin observed by ftir spectroscopy","volume":"13","author":"Duca","year":"2018","journal-title":"Chemistry Journal of Moldova"},{"issue":"1\u20132","key":"10.1016\/bs.apcsb.2020.09.002_bib25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbrc.2017.10.083","article-title":"Regulatory mechanisms for iron transport across the blood-brain barrier","volume":"494","author":"Duck","year":"2017","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"32","key":"10.1016\/bs.apcsb.2020.09.002_bib26","doi-asserted-by":"crossref","first-page":"13089","DOI":"10.1073\/pnas.1105786108","article-title":"How the binding of human transferrin primes the transferrin receptor potentiating iron release at endosomal pH","volume":"108","author":"Eckenroth","year":"2011","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib27","article-title":"Sanfilippo syndrome: Causes, consequences, and treatments","volume":"269","author":"Fedele","year":"2015","journal-title":"The Application of Clinical Genetics"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408347.2020.1743639","article-title":"A review of properties, delivery systems and analytical methods for the characterization of monomeric glycoprotein transferrin","author":"Fernandes","year":"2020","journal-title":"Critical Reviews in Analytical Chemistry"},{"issue":"3","key":"10.1016\/bs.apcsb.2020.09.002_bib29","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.bbagen.2011.06.018","article-title":"Lactoferrin a multiple bioactive protein: An overview","volume":"1820","author":"Garc\u00eda-Montoya","year":"2012","journal-title":"Biochimica et Biophysica Acta (BBA) - General Subjects"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fnagi.2020.00038","article-title":"Association of plasma transferrin with cognitive decline in patients with mild cognitive impairment and Alzheimer\u2019s disease","volume":"12","author":"Guan","year":"2020","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"6","key":"10.1016\/bs.apcsb.2020.09.002_bib31","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/ana.23974","article-title":"Iron and neurodegeneration in the multiple sclerosis brain: Iron in the MS Brain","volume":"74","author":"Hametner","year":"2013","journal-title":"Annals of Neurology"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib32","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3389\/fphar.2020.00239","article-title":"Ferroptosis and its potential role in human diseases","volume":"11","author":"Han","year":"2020","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2013.00034","article-title":"A delicate balance: Iron metabolism and diseases of the brain","volume":"5","author":"Hare","year":"2013","journal-title":"Frontiers in Aging Neuroscience"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2017.08.004","article-title":"Modelling iron mismanagement in neurodegenerative disease in vitro: Paradigms, pitfalls, possibilities & practical considerations","volume":"158","author":"Healy","year":"2017","journal-title":"Progress in Neurobiology"},{"issue":"2","key":"10.1016\/bs.apcsb.2020.09.002_bib35","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3390\/jcm9020344","article-title":"Molecular bases of neurodegeneration and cognitive decline, the major burden of Sanfilippo disease","volume":"9","author":"Heon-Roberts","year":"2020","journal-title":"Journal of Clinical Medicine"},{"issue":"7","key":"10.1016\/bs.apcsb.2020.09.002_bib36","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1271\/bbb.64.1328","article-title":"The structural mechanism for iron uptake and release by transferrins","volume":"64","author":"Hirose","year":"2000","journal-title":"Bioscience Biotechnology and Biochemistry"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib37","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.neubiorev.2019.11.021","article-title":"Aging: Therapeutics for a healthy future","volume":"108","author":"Hodgson","year":"2020","journal-title":"Neuroscience & Biobehavioral Reviews"},{"issue":"2","key":"10.1016\/bs.apcsb.2020.09.002_bib38","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1016\/j.ymgme.2015.12.413","article-title":"Alteration of cerebral iron metabolism in Sanfilippo syndrome","volume":"117","author":"Hodroge","year":"2016","journal-title":"Molecular Genetics and Metabolism"},{"issue":"6","key":"10.1016\/bs.apcsb.2020.09.002_bib39","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1042\/BST20130114","article-title":"Uptake and metabolism of iron and iron oxide nanoparticles in brain astrocytes","volume":"41","author":"Hohnholt","year":"2013","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib40","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3389\/fnins.2019.00575","article-title":"DMT1 expression and iron levels at the crossroads between aging and neurodegeneration","volume":"13","author":"Ingrassia","year":"2019","journal-title":"Frontiers in Neuroscience"},{"issue":"40","key":"10.1016\/bs.apcsb.2020.09.002_bib41","doi-asserted-by":"crossref","first-page":"13978","DOI":"10.1021\/bi9812064","article-title":"Ligand-Induced conformational change in transferrins: Crystal structure of the open form of the N-terminal half-molecule of human transferrin \u2020 , \u2021","volume":"37","author":"Jeffrey","year":"1998","journal-title":"Biochemistry"},{"issue":"5","key":"10.1016\/bs.apcsb.2020.09.002_bib42","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3945\/jn.114.207316","article-title":"Hephaestin and ceruloplasmin play distinct but interrelated roles in iron homeostasis in mouse brain","volume":"145","author":"Jiang","year":"2015","journal-title":"Journal of Nutrition"},{"issue":"15","key":"10.1016\/bs.apcsb.2020.09.002_bib43","first-page":"155","article-title":"The contribution of iron to protein aggregation disorders in the central nervous system","volume":"13","author":"Joppe","year":"2019","journal-title":"Frontiers in Neuroscience"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib44","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2018.06.037","article-title":"Transferrin and transferrin receptors update","volume":"133","author":"Kawabata","year":"2019","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib45","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.freeradbiomed.2018.10.413","article-title":"Non-transferrin-bound iron transporters","volume":"133","author":"Knutson","year":"2019","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib46","series-title":"Sweet biochemistry","first-page":"75","article-title":"Mucopolysaccharidoses","author":"Kumari","year":"2018"},{"issue":"3","key":"10.1016\/bs.apcsb.2020.09.002_bib47","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.bbagen.2011.06.002","article-title":"Molecular evolution of the transferrin family and associated receptors","volume":"1820","author":"Lambert","year":"2012","journal-title":"Biochimica et Biophysica Acta (BBA) - General Subjects"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib48","doi-asserted-by":"crossref","first-page":"101274","DOI":"10.1016\/j.smrv.2020.101274","article-title":"Iron deficiency and sleep \u2013 a scoping review","volume":"51","author":"Leung","year":"2020","journal-title":"Sleep Medicine Reviews"},{"issue":"2","key":"10.1016\/bs.apcsb.2020.09.002_bib49","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/s41419-020-2298-2","article-title":"Ferroptosis: Past, present and future","volume":"11","author":"Li","year":"2020","journal-title":"Cell Death and Disease"},{"issue":"2","key":"10.1016\/bs.apcsb.2020.09.002_bib50","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1136\/jnnp-2018-318650","article-title":"Lifetime risk of common neurological diseases in the elderly population","volume":"90","author":"Licher","year":"2019","journal-title":"Journal of Neurology, Neurosurgery and Psychiatry"},{"issue":"3","key":"10.1016\/bs.apcsb.2020.09.002_bib51","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/med.10008","article-title":"Transferrin\/transferrin receptor-mediated drug delivery","volume":"22","author":"Li","year":"2002","journal-title":"Medicinal Research Reviews"},{"issue":"632","key":"10.1016\/bs.apcsb.2020.09.002_bib52","first-page":"10","article-title":"Iron and Alzheimer\u2019s disease: From pathogenesis to therapeutic implications","volume":"12","author":"Liu","year":"2018","journal-title":"Frontiers in Neuroscience"},{"issue":"6","key":"10.1016\/bs.apcsb.2020.09.002_bib53","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1021\/bi991522y","article-title":"Mutation of the iron ligand His 249 to glu in the N-lobe of human transferrin abolishes the dilysine \u201ctrigger\u201d but does not significantly affect iron release \u2020 , \u2021","volume":"39","author":"MacGillivray","year":"2000","journal-title":"Biochemistry"},{"issue":"22","key":"10.1016\/bs.apcsb.2020.09.002_bib54","doi-asserted-by":"crossref","first-page":"7919","DOI":"10.1021\/bi980355j","article-title":"Two high-resolution crystal structures of the recombinant N-lobe of human transferrin reveal a structural change implicated in iron release \u2020 , \u2021","volume":"37","author":"MacGillivray","year":"1998","journal-title":"Biochemistry"},{"issue":"4","key":"10.1016\/bs.apcsb.2020.09.002_bib55","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s00018-014-1771-4","article-title":"Iron transport across the blood\u2013brain barrier: Development, neurovascular regulation and cerebral amyloid angiopathy","volume":"72","author":"McCarthy","year":"2015","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"2","key":"10.1016\/bs.apcsb.2020.09.002_bib56","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S2215-0366(19)30405-5","article-title":"Functional cognitive disorders: A systematic review","volume":"7","author":"McWhirter","year":"2020","journal-title":"The Lancet Psychiatry"},{"issue":"1","key":"10.1016\/bs.apcsb.2020.09.002_bib57","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4155\/fmc.09.140","article-title":"Mechanisms of brain iron transport: Insight into neurodegeneration and CNS disorders","volume":"2","author":"Mills","year":"2010","journal-title":"Future Medicinal Chemistry"},{"issue":"6","key":"10.1016\/bs.apcsb.2020.09.002_bib58","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.tins.2019.03.009","article-title":"Iron, myelin, and the brain: Neuroimaging meets neurobiology","volume":"42","author":"M\u00f6ller","year":"2019","journal-title":"Trends in Neurosciences"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib59","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.3389\/fnins.2019.01195","article-title":"Iron, ferritin, hereditary ferritinopathy, and neurodegeneration","volume":"13","author":"Muhoberac","year":"2019","journal-title":"Frontiers in Neuroscience"},{"issue":"1","key":"10.1016\/bs.apcsb.2020.09.002_bib60","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40478-018-0515-3","article-title":"White matter changes in Alzheimer\u2019s disease: A focus on myelin and oligodendrocytes","volume":"6","author":"Nasrabady","year":"2018","journal-title":"Acta Neuropathologica Communications"},{"issue":"Suppl. ment_7","key":"10.1016\/bs.apcsb.2020.09.002_bib61","doi-asserted-by":"crossref","first-page":"S529","DOI":"10.1093\/cid\/ciz825","article-title":"The role of iron and siderophores in infection, and the development of siderophore antibiotics","volume":"69","author":"Page","year":"2019","journal-title":"Clinical Infectious Diseases"},{"issue":"6","key":"10.1016\/bs.apcsb.2020.09.002_bib62","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s40259-017-0248-z","article-title":"Delivery of biologics across the blood\u2013brain barrier with molecular trojan horse technology","volume":"31","author":"Pardridge","year":"2017","journal-title":"BioDrugs"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib63","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fnagi.2019.00373","article-title":"Blood-brain barrier and delivery of protein and gene therapeutics to brain","volume":"11","author":"Pardridge","year":"2020","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"1","key":"10.1016\/bs.apcsb.2020.09.002_bib64","doi-asserted-by":"crossref","first-page":"10547","DOI":"10.1038\/s41598-017-10593-7","article-title":"Restless legs syndrome in Parkinson disease: Clinical characteristics, abnormal iron metabolism and altered neurotransmitters","volume":"7","author":"Piao","year":"2017","journal-title":"Scientific Reports"},{"issue":"12","key":"10.1016\/bs.apcsb.2020.09.002_bib65","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.3390\/cells8121525","article-title":"Advanced age is associated with iron dyshomeostasis and mitochondrial DNA damage in human skeletal muscle","volume":"8","author":"Picca","year":"2019","journal-title":"Cells"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib66","doi-asserted-by":"crossref","first-page":"105314","DOI":"10.1016\/j.ejps.2020.105314","article-title":"Quercetin lipid nanoparticles functionalized with transferrin for Alzheimer\u2019s disease","volume":"148","author":"Pinheiro","year":"2020","journal-title":"European Journal of Pharmaceutical Sciences"},{"issue":"2","key":"10.1016\/bs.apcsb.2020.09.002_bib67","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/00207454.2016.1174118","article-title":"Brain biometals and Alzheimer\u2019s disease \u2013 boon or bane?","volume":"127","author":"Prakash","year":"2017","journal-title":"International Journal of Neuroscience"},{"issue":"8","key":"10.1016\/bs.apcsb.2020.09.002_bib68","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/glia.23335","article-title":"Predominant role of microglia in brain iron retention in Sanfilippo syndrome, a pediatric neurodegenerative disease","volume":"66","author":"Puy","year":"2018","journal-title":"Glia"},{"issue":"5","key":"10.1016\/bs.apcsb.2020.09.002_bib69","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1111\/brv.12521","article-title":"Brain iron transport","volume":"94","author":"Qian","year":"2019","journal-title":"Biological Reviews"},{"issue":"2","key":"10.1016\/bs.apcsb.2020.09.002_bib70","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.nic.2016.12.003","article-title":"Iron mapping in multiple sclerosis","volume":"27","author":"Ropele","year":"2017","journal-title":"Neuroimaging Clinics of North America"},{"issue":"8","key":"10.1016\/bs.apcsb.2020.09.002_bib71","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nrn3453","article-title":"Iron metabolism in the CNS: Implications for neurodegenerative diseases","volume":"14","author":"Rouault","year":"2013","journal-title":"Nature Reviews Neuroscience"},{"issue":"1","key":"10.1016\/bs.apcsb.2020.09.002_bib72","doi-asserted-by":"crossref","first-page":"53","DOI":"10.31080\/ASNE.2020.03.neurological-diseases-associated-with-brain-iron-accumulation","article-title":"Neurological diseases associated with brain iron accumulation","volume":"3","author":"Roy Sarkar","year":"2019","journal-title":"Acta Scientific Neurology"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib73","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fmolb.2018.00099","article-title":"Loss of Ca2+\/calmodulin dependent protein kinase kinase 2 leads to aberrant transferrin phosphorylation and trafficking: A potential biomarker for Alzheimer\u2019s disease","volume":"5","author":"Sabbir","year":"2018","journal-title":"Frontiers in Molecular Biosciences"},{"issue":"1","key":"10.1016\/bs.apcsb.2020.09.002_bib74","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/hbm.22612","article-title":"The role of iron in gray matter degeneration in Huntington\u2019s disease: A magnetic resonance imaging study: The role of iron in gray matter loss in HD","volume":"36","author":"S\u00e1nchez-Casta\u00f1eda","year":"2015","journal-title":"Human Brain Mapping"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib75","doi-asserted-by":"crossref","first-page":"126499","DOI":"10.1016\/j.jtemb.2020.126499","article-title":"Neurodevelopmental disorders: Metallomics studies for the identification of potential biomarkers associated to diagnosis and treatment","volume":"60","author":"Scassellati","year":"2020","journal-title":"Journal of Trace Elements in Medicine & Biology"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib76","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.mad.2017.11.012","article-title":"Ferrosenescence: The iron age of neurodegeneration?","volume":"174","author":"Sfera","year":"2018","journal-title":"Mechanism of Ageing and Development"},{"issue":"9","key":"10.1016\/bs.apcsb.2020.09.002_bib77","doi-asserted-by":"crossref","first-page":"495","DOI":"10.3390\/biom9090495","article-title":"Unraveling binding mechanism of Alzheimer\u2019s drug rivastigmine tartrate with human transferrin: Molecular docking and multi-spectroscopic approach towards neurodegenerative diseases","volume":"9","author":"Shamsi","year":"2019","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/bs.apcsb.2020.09.002_bib78","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/jcbfm.2014.168","article-title":"A novel model for brain iron uptake: Introducing the concept of regulation","volume":"35","author":"Simpson","year":"2015","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"issue":"2","key":"10.1016\/bs.apcsb.2020.09.002_bib79","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s11030-018-9878-4","article-title":"A review on iron chelators as potential therapeutic agents for the treatment of Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"23","author":"Singh","year":"2019","journal-title":"Molecular Diversity"},{"issue":"86","key":"10.1016\/bs.apcsb.2020.09.002_bib80","first-page":"174","article-title":"Oxidative stress related to iron metabolism in relapsing remitting multiple sclerosis patients with low disability","volume":"13","author":"Siotto","year":"2019","journal-title":"Frontiers in Neuroscience"},{"issue":"9","key":"10.1016\/bs.apcsb.2020.09.002_bib81","first-page":"1073","article-title":"Comparison of interaction between ceruloplasmin and lactoferrin\/transferrin: To bind or not to bind","volume":"82","author":"Sokolov","year":"2017","journal-title":"Biochemistry"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib82","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.neurobiolaging.2014.03.039","article-title":"Iron and multiple sclerosis","volume":"35","author":"Stankiewicz","year":"2014","journal-title":"Neurobiology of Aging"},{"issue":"859","key":"10.1016\/bs.apcsb.2020.09.002_bib83","first-page":"68","article-title":"Kinetic modeling of pH-dependent oxidation of dopamine by iron and its relevance to Parkinson\u2019s disease","volume":"12","author":"Sun","year":"2018","journal-title":"Frontiers in Neuroscience"},{"issue":"2","key":"10.1016\/bs.apcsb.2020.09.002_bib84","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1159\/000147479","article-title":"Sugar chains of cerebrospinal fluid transferrin as a new biological marker of Alzheimer\u2019s disease","volume":"26","author":"Taniguchi","year":"2008","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib85","doi-asserted-by":"crossref","first-page":"106242","DOI":"10.1016\/j.bpc.2019.106242","article-title":"Structural analysis of the transferrin receptor multifaceted ligand(s) interface","volume":"254","author":"Testi","year":"2019","journal-title":"Biophysical Chemistry"},{"issue":"6","key":"10.1016\/bs.apcsb.2020.09.002_bib86","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1111\/j.1471-4159.2008.05678.x","article-title":"Tim-2 is the receptor for H-ferritin on oligodendrocytes","volume":"107","author":"Todorich","year":"2008","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2018\/2850341","article-title":"Unraveling the burden of iron in neurodegeneration: Intersections with amyloid beta peptide pathology","volume":"2018","author":"Uranga","year":"2018","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"4","key":"10.1016\/bs.apcsb.2020.09.002_bib88","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.revmed.2020.01.001","article-title":"Le syndrome des jambes sans repos","volume":"41","author":"Vellieux","year":"2020","journal-title":"La Revue de Medecine Interne"},{"issue":"34","key":"10.1016\/bs.apcsb.2020.09.002_bib89","doi-asserted-by":"crossref","first-page":"24934","DOI":"10.1074\/jbc.M604592200","article-title":"The crystal structure of iron-free human serum transferrin provides insight into inter-lobe communication and receptor binding","volume":"281","author":"Wally","year":"2006","journal-title":"Journal of Biological Chemistry"},{"issue":"37","key":"10.1016\/bs.apcsb.2020.09.002_bib90","doi-asserted-by":"crossref","first-page":"7867","DOI":"10.1039\/C4CC09642H","article-title":"\u201cAnion clamp\u201d allows flexible protein to impose coordination geometry on metal ions","volume":"51","author":"Wang","year":"2015","journal-title":"Chemical Communications"},{"issue":"1","key":"10.1016\/bs.apcsb.2020.09.002_bib91","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40035-020-00189-z","article-title":"Current understanding of metal ions in the pathogenesis of Alzheimer\u2019s disease","volume":"9","author":"Wang","year":"2020","journal-title":"Translational Neurodegeneration"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib92","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mad.2018.07.003","article-title":"Iron status in the elderly: A review of recent evidence","volume":"175","author":"Wawer","year":"2018","journal-title":"Mechanism of Ageing and Development"},{"issue":"3","key":"10.1016\/bs.apcsb.2020.09.002_bib93","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.bbagen.2011.10.006","article-title":"The transfer of iron between ceruloplasmin and transferrins","volume":"1820","author":"White","year":"2012","journal-title":"Biochimica et Biophysica Acta (BBA) - General Subjects"},{"issue":"1","key":"10.1016\/bs.apcsb.2020.09.002_bib94","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/neup.12611","article-title":"Immunoreactivities for hepcidin, ferroportin, and hephaestin in astrocytes and choroid plexus epithelium of human brains","volume":"40","author":"Yanase","year":"2020","journal-title":"Neuropathology"},{"issue":"1","key":"10.1016\/bs.apcsb.2020.09.002_bib95","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/srep00999","article-title":"Iron and bismuth bound human serum transferrin reveals a partially-opened conformation in the N-lobe","volume":"2","author":"Yang","year":"2012","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/bs.apcsb.2020.09.002_bib96","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12883-018-1016-5","article-title":"Clinical features and dysfunctions of iron metabolism in Parkinson disease patients with hyper echogenicity in substantia nigra: A cross-sectional study","volume":"18","author":"Yu","year":"2018","journal-title":"BMC Neurology"},{"key":"10.1016\/bs.apcsb.2020.09.002_bib97","series-title":"Iron and neurodegeneration","year":"2020"},{"issue":"1","key":"10.1016\/bs.apcsb.2020.09.002_bib98","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41598-016-0018-z","article-title":"Serotonergic dysfunctions and abnormal iron metabolism: Relevant to mental fatigue of Parkinson disease","volume":"6","author":"Zuo","year":"2016","journal-title":"Scientific Reports"}],"container-title":["Advances in Protein Chemistry and Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876162320300638?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876162320300638?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T16:18:24Z","timestamp":1761754704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876162320300638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9780128220870"],"references-count":98,"URL":"https:\/\/doi.org\/10.1016\/bs.apcsb.2020.09.002","relation":{},"ISSN":["1876-1623"],"issn-type":[{"value":"1876-1623","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]}}}