{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T20:08:27Z","timestamp":1785355707441,"version":"3.55.0"},"reference-count":87,"publisher":"Elsevier","isbn-type":[{"value":"9780443188862","type":"print"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/bs.apcsb.2023.02.016","type":"book-chapter","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T19:55:34Z","timestamp":1684785334000},"page":"309-337","source":"Crossref","is-referenced-by-count":8,"title":["Targeting mitochondrial dysfunction to salvage cellular senescence for managing neurodegeneration"],"prefix":"10.1016","author":[{"given":"Komal","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyobrata","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anchal","family":"Trisal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishika","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anubhuti","family":"Dixit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.apcsb.2023.02.016_bib1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fnagi.2020.00252","article-title":"Mitochondrial dysfunction and Alzheimer\u2019s disease: Role of microglia","volume":"12","author":"Agrawal","year":"2020","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"3","key":"10.1016\/bs.apcsb.2023.02.016_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00232-008-9108-6","article-title":"Protective effects of mitochondria-targeted antioxidant SkQ in aqueous and lipid membrane environments","volume":"222","author":"Antonenko","year":"2008","journal-title":"Journal of Membrane Biology"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/978-3-7091-7508-8_14","article-title":"Aberrancies in signal transduction and cell cycle related events in Alzheimer\u2019s disease","volume":"54","author":"Arendt","year":"1998","journal-title":"Journal of Neural Transmission, Supplement"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.02.016_bib4","first-page":"333","article-title":"The role of mitochondrial dysfunction in Alzheimer\u2019s disease pathogenesis. Alzheimer\u2019s & dementia: The journal of the Alzheimer\u2019s Association","volume":"19","author":"Ashleigh","year":"2023"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.02.016_bib5","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s10522-022-09973-y","article-title":"Mitochondria-targeted senotherapeutic interventions","volume":"23","author":"Atayik","year":"2022","journal-title":"Biogerontology"},{"issue":"5556","key":"10.1016\/bs.apcsb.2023.02.016_bib6","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1126\/science.1067389","article-title":"Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson\u2019s disease","volume":"295","author":"Auluck","year":"2002","journal-title":"Science (New York, N. Y.)"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.02.016_bib7","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cmet.2011.03.004","article-title":"PARP-1 inhibition increases mitochondrial metabolism through SIRT1 activation","volume":"13","author":"Bai","year":"2011","journal-title":"Cell Metabolism"},{"issue":"16","key":"10.1016\/bs.apcsb.2023.02.016_bib8","doi-asserted-by":"crossref","first-page":"4212","DOI":"10.1093\/emboj\/cdg417","article-title":"Reversal of human cellular senescence: Roles of the p53 and p16 pathways","volume":"22","author":"Beaus\u00e9jour","year":"2003","journal-title":"The EMBO Journal"},{"issue":"10","key":"10.1016\/bs.apcsb.2023.02.016_bib9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.tcb.2020.07.002","article-title":"A senescence-centric view of aging: Implications for longevity and disease","volume":"30","author":"Borghesan","year":"2020","journal-title":"Trends in Cell Biology"},{"issue":"7728","key":"10.1016\/bs.apcsb.2023.02.016_bib10","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-018-0543-y","article-title":"Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline","volume":"562","author":"Bussian","year":"2018","journal-title":"Nature"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib11","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1152\/physrev.00020.2018","article-title":"Cellular senescence: aging, cancer, and injury","volume":"99","author":"Calcinotto","year":"2019","journal-title":"Physiological Reviews"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0092-8674(00)81023-5","article-title":"Replicative senescence: Minireview an old lives\u2019 tale?","volume":"84","author":"Campisi","year":"1996","journal-title":"Cell"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.02.016_bib13","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1523\/JNEUROSCI.20-01-00240.2000","article-title":"AMPA exposures induce mitochondrial Ca2+ overload and ROS generation in spinal motor neurons in vitro","volume":"20","author":"Carriedo","year":"2000","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.02.016_bib14","doi-asserted-by":"crossref","DOI":"10.1186\/s40035-019-0158-8","article-title":"Current progress of mitochondrial transplantation that promotes neuronal regeneration","volume":"8","author":"Chang","year":"2019","journal-title":"Translational Neurodegeneration"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.02.016_bib15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3390\/biology8020038","article-title":"Mitochondrial dysfunction in Parkinson\u2019s disease\u2014cause or consequence?","volume":"8","author":"Chen","year":"2019","journal-title":"Biology"},{"issue":"12","key":"10.1016\/bs.apcsb.2023.02.016_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0060301","article-title":"Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor","volume":"6","author":"Copp\u00e9","year":"2008","journal-title":"PLoS Biology"},{"issue":"23","key":"10.1016\/bs.apcsb.2023.02.016_bib17","doi-asserted-by":"crossref","first-page":"3051","DOI":"10.1101\/gad.847700","article-title":"Ablation of the retinoblastoma gene family deregulates G(1) control causing immortalization and increased cell turnover under growth-restricting conditions","volume":"14","author":"Dannenberg","year":"2000","journal-title":"Genes & Development"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1146\/annurev.neuro.30.051606.094302","article-title":"Mitochondrial disorders in the nervous system","volume":"31","author":"DiMauro","year":"2008","journal-title":"Annual Review of Neuroscience"},{"issue":"14","key":"10.1016\/bs.apcsb.2023.02.016_bib19","doi-asserted-by":"crossref","first-page":"11731","DOI":"10.1074\/jbc.C300023200","article-title":"Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53","volume":"278","author":"Dirac","year":"2003","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.02.016_bib20","doi-asserted-by":"crossref","first-page":"BR91","DOI":"10.12659\/MSM.881706","article-title":"Mitochondrial dysfunction in long-term neuronal cultures mimics changes with aging","volume":"17","author":"Dong","year":"2011","journal-title":"Medical Science Monitor: International Medical Journal of Experimental and Clinical Research"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib21","unstructured":"Doody, R. S., Gavrilova, S. I., Sano, M., Thomas, R. G., Aisen, P. S., Bachurin, S. O., \u2026 Hung, D. (n.d.). Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer\u2019s disease: a randomised, double-blind, placebo-controlled study.\u00a0www.thelancet.com."},{"issue":"4","key":"10.1016\/bs.apcsb.2023.02.016_bib22","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.bbadis.2013.01.008","article-title":"Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration","volume":"1832","author":"Duarte","year":"2013","journal-title":"Biochimica et Biophysica Acta"},{"issue":"3","key":"10.1016\/bs.apcsb.2023.02.016_bib23","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1124\/jpet.112.195586","article-title":"Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells","volume":"342","author":"Fink","year":"2012","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"7513","key":"10.1016\/bs.apcsb.2023.02.016_bib24","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nature13619","article-title":"Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells","volume":"512","author":"Flach","year":"2014","journal-title":"Nature"},{"issue":"5","key":"10.1016\/bs.apcsb.2023.02.016_bib25","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1096\/fj.07-9348com","article-title":"Genetic variability in the SNCA gene influences \u03b1\u2010synuclein levels in the blood and brain","volume":"22","author":"Fuchs","year":"2008","journal-title":"The FASEB Journal"},{"issue":"7","key":"10.1016\/bs.apcsb.2023.02.016_bib26","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nrn2665","article-title":"Mitochondrial membrane permeabilization in neuronal injury","volume":"10","author":"Galluzzi","year":"2009","journal-title":"Nature Reviews. Neuroscience"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.02.016_bib27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1038\/cdd.2011.96","article-title":"Molecular definitions of cell death subroutines: Recommendations of the Nomenclature Committee on Cell Death 2012","volume":"19","author":"Galluzzi","year":"2011","journal-title":"Cell Death & Differentiation"},{"issue":"3","key":"10.1016\/bs.apcsb.2023.02.016_bib28","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0014-4827(61)90192-6","article-title":"The serial cultivation of human diploid cell strains","volume":"25","author":"Hayflick","year":"1961","journal-title":"Experimental Cell Research"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.02.016_bib29","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.exger.2011.11.012","article-title":"Telomere length is age-dependent and reduced in monocytes of Alzheimer patients","volume":"47","author":"Hochstrasser","year":"2012","journal-title":"Experimental Gerontology"},{"issue":"15","key":"10.1016\/bs.apcsb.2023.02.016_bib30","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1056\/NEJMra0804615","article-title":"DNA damage, aging, and cancer","volume":"361","author":"Hoeijmakers","year":"2009","journal-title":"New England Journal of Medicine"},{"issue":"10","key":"10.1016\/bs.apcsb.2023.02.016_bib31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41582-019-0244-7","article-title":"Ageing as a risk factor for neurodegenerative disease","volume":"15","author":"Hou","year":"2019","journal-title":"Nature Reviews. Neurology"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.02.016_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","article-title":"National Institute on Aging-Alzheimer\u2019s Association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimer\u2019s & Dementia: The Journal of the Alzheimer\u2019s Association"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib33","first-page":"7","article-title":"NAD+ biosynthesis, aging, and disease","author":"Imai","year":"2018","journal-title":"F1000Research"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.02.016_bib34","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1128\/MCB.23.1.389-401.2003","article-title":"Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1","volume":"23","author":"Itahana","year":"2003","journal-title":"Molecular and Cellular Biology"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.02.016_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2047-9158-4-3","article-title":"Treatment of the later stages of Parkinson\u2019s disease\u2014pharmacological approaches now and in the future","volume":"4","author":"Jenner","year":"2015","journal-title":"Translational Neurodegeneration"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.02.016_bib36","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.bbamcr.2011.01.026","article-title":"Caspase-8 and bid: caught in the act between death receptors and mitochondria","volume":"1813","author":"Kantari","year":"2011","journal-title":"Biochimica et Biophysica Acta"},{"issue":"7","key":"10.1016\/bs.apcsb.2023.02.016_bib37","doi-asserted-by":"crossref","first-page":"4588","DOI":"10.1074\/jbc.M009093200","article-title":"Selective targeting of a redox-active ubiquinone to mitochondria within cells: Antioxidant and antiapoptotic properties","volume":"276","author":"Kelso","year":"2001","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.02.016_bib38","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.cell.2005.01.027","article-title":"Understanding the odd science of aging","volume":"120","author":"Kirkwood","year":"2005","journal-title":"Cell"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.02.016_bib39","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1006\/excr.1995.1095","article-title":"Increased p53 protein associated with aging in human diploid fibroblasts","volume":"217","author":"Kulju","year":"1995","journal-title":"Experimental Cell Research"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib40","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.freeradbiomed.2021.05.003","article-title":"Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases","volume":"171","author":"Lagoumtzi","year":"2021","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib41","article-title":"PARK\u00a0genes link mitochondrial dysfunction and alpha-synuclein pathology in sporadic Parkinson\u2019s disease","volume":"9","author":"Li","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"issue":"6","key":"10.1016\/bs.apcsb.2023.02.016_bib42","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"issue":"6","key":"10.1016\/bs.apcsb.2023.02.016_bib43","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","volume":"72","author":"MacDonald","year":"1993","journal-title":"Cell"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.02.016_bib44","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1042\/BST20170501","article-title":"Mitochondrial abnormalities in Parkinson\u2019s disease and Alzheimer\u2019s disease: Can mitochondria be targeted therapeutically?","volume":"46","author":"Macdonald","year":"2018","journal-title":"Biochemical Society Transactions"},{"issue":"12","key":"10.1016\/bs.apcsb.2023.02.016_bib45","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.3390\/biomedicines10123228","article-title":"Exercise-boosted mitochondrial remodeling in Parkinson\u2019s disease","volume":"10","author":"Maga\u00f1a","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4061\/2009\/951548","article-title":"Mitochondria, cognitive impairment, and Alzheimer\u2019s disease","volume":"2009","author":"Mancuso","year":"2009","journal-title":"International Journal of Alzheimer\u2019s Disease"},{"issue":"3","key":"10.1016\/bs.apcsb.2023.02.016_bib47","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3390\/biom10030420","article-title":"Role of p53 in the regulation of cellular senescence","volume":"10","author":"Mijit","year":"2020","journal-title":"Biomolecules"},{"issue":"13","key":"10.1016\/bs.apcsb.2023.02.016_bib48","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158447","article-title":"Mitochondrial dysfunction in cell senescence and aging","volume":"132","author":"Miwa","year":"2022","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib49","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.766306","article-title":"Senescence in primary rat astrocytes induces loss of the mitochondrial membrane potential and alters mitochondrial dynamics in cortical neurons","volume":"13","author":"Morales-Rosales","year":"2021","journal-title":"Frontiers in aging neuroscience"},{"issue":"6","key":"10.1016\/bs.apcsb.2023.02.016_bib50","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12840","article-title":"Tau protein aggregation is associated with cellular senescence in the brain","volume":"17","author":"Musi","year":"2018","journal-title":"Aging Cell"},{"issue":"6","key":"10.1016\/bs.apcsb.2023.02.016_bib51","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0092-8674(03)00401-X","article-title":"Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence","volume":"113","author":"Narita","year":"2003","journal-title":"Cell"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.02.016_bib52","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s41536-020-00107-x","article-title":"Mitochondrial dysfunction in neurological disorders: Exploring mitochondrial transplantation","volume":"5","author":"Norat","year":"2020","journal-title":"npj Regenerative Medicine"},{"issue":"35","key":"10.1016\/bs.apcsb.2023.02.016_bib53","doi-asserted-by":"crossref","first-page":"4974","DOI":"10.1038\/sj.onc.1202880","article-title":"Murine fibroblasts lacking p21 undergo senescence and are resistant to transformation by oncogenic Ras","volume":"18","author":"Pantoja","year":"1999","journal-title":"Oncogene"},{"issue":"6\u20137","key":"10.1016\/bs.apcsb.2023.02.016_bib54","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/BF01291884","article-title":"Alterations in the distribution of glutathione in the substantia nigra in Parkinson\u2019s disease","volume":"104","author":"Pearce","year":"1997","journal-title":"Journal of Neural Transmission"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib55","doi-asserted-by":"crossref","DOI":"10.5772\/64327","article-title":"New targets for diagnosis and treatment against Alzheimer\u2019s disease: The mitochondrial approach","author":"P\u00e9rez","year":"2016"},{"issue":"5","key":"10.1016\/bs.apcsb.2023.02.016_bib56","first-page":"361","article-title":"Study questions effectiveness of Alzheimer\u2019s drug","volume":"4","author":"Petersen","year":"2005","journal-title":"Nature Reviews. Drug Discovery"},{"issue":"5321","key":"10.1016\/bs.apcsb.2023.02.016_bib57","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1126\/science.276.5321.2045","article-title":"Mutation in the alpha-synuclein gene identified in families with Parkinson\u2019s disease","volume":"276","author":"Polymeropoulos","year":"1997","journal-title":"Science (New York, N. Y.)"},{"issue":"8","key":"10.1016\/bs.apcsb.2023.02.016_bib58","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1017\/S1092852900024901","article-title":"Role of mitochondria in neurodegenerative diseases: mitochondria as a therapeutic target in Alzheimer\u2019s disease","volume":"14","author":"Reddy","year":"2009","journal-title":"CNS Spectrums"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib59","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/B978-0-12-385883-2.00002-3","article-title":"The complex molecular biology of amyotrophic lateral sclerosis (ALS)","volume":"107","author":"Redler","year":"2012","journal-title":"Progress in Molecular Biology and Translational Science"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.02.016_bib60","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nrn3430","article-title":"The changing scene of amyotrophic lateral sclerosis","volume":"14","author":"Robberecht","year":"2013","journal-title":"Nature Reviews. Neuroscience"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.02.016_bib61","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1006\/excr.2000.5149","article-title":"p16(MTS-1\/CDKN2\/INK4a) in cancer progression","volume":"264","author":"Rocco","year":"2001","journal-title":"Experimental Cell Research"},{"issue":"23","key":"10.1016\/bs.apcsb.2023.02.016_bib62","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1101\/gad.843200","article-title":"Targeted disruption of the three Rb-related genes leads to loss of G(1) control and immortalization","volume":"14","author":"Sage","year":"2000","journal-title":"Genes & Development"},{"issue":"17","key":"10.1016\/bs.apcsb.2023.02.016_bib63","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1056\/NEJM199704243361704","article-title":"A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer\u2019s disease. The Alzheimer\u2019s Disease Cooperative Study","volume":"336","author":"Sano","year":"1997","journal-title":"The New England Journal of Medicine"},{"issue":"13","key":"10.1016\/bs.apcsb.2023.02.016_bib64","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1096\/fj.07-8329com","article-title":"Reactive oxygen species alter brain endothelial tight junction dynamics via RhoA, PI3 kinase, and PKB signaling","volume":"21","author":"Schreibelt","year":"2007","journal-title":"FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.02.016_bib65","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1073\/pnas.0910216107","article-title":"Penetrating cation\/fatty acid anion pair as a mitochondria-targeted protonophore","volume":"107","author":"Severin","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib66","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3389\/fneur.2020.00929","article-title":"Interleukin-1\u03b2 drives cellular senescence of rat astrocytes induced by oligomerized amyloid \u03b2 peptide and oxidative stress","volume":"11","author":"Shang","year":"2020","journal-title":"Frontiers in Neurology"},{"issue":"6851","key":"10.1016\/bs.apcsb.2023.02.016_bib67","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35092592","article-title":"Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis","volume":"413","author":"Sharpless","year":"2001","journal-title":"Nature"},{"issue":"16","key":"10.1016\/bs.apcsb.2023.02.016_bib68","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1093\/emboj\/cdf433","article-title":"Different telomere damage signaling pathways in human and mouse cells","volume":"21","author":"Smogorzewska","year":"2002","journal-title":"The EMBO Journal"},{"issue":"12","key":"10.1016\/bs.apcsb.2023.02.016_bib69","first-page":"1321","article-title":"Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging","volume":"33","author":"Stein","year":"2014","journal-title":"The EMBO Journal"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib70","unstructured":"Sweetlove, M. (n.d.). Phase III CONCERT Trial of Latrepirdine Negative Results. \u3008http:\/\/www.pfizer.com\u3009."},{"issue":"4","key":"10.1016\/bs.apcsb.2023.02.016_bib71","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/ana.410400417","article-title":"Origin and functional consequences of the complex I defect in Parkinson\u2019s disease","volume":"40","author":"Swerdlow","year":"1996","journal-title":"Annals of Neurology"},{"issue":"6","key":"10.1016\/bs.apcsb.2023.02.016_bib72","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10522-014-9532-1","article-title":"Are there roles for brain cell senescence in aging and neurodegenerative disorders?","volume":"15","author":"Tan","year":"2014","journal-title":"Biogerontology"},{"issue":"6","key":"10.1016\/bs.apcsb.2023.02.016_bib73","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/glia.23768","article-title":"Schwann cells orchestrate peripheral nerve inflammation through the expression of CSF1, IL-34, and SCF in amyotrophic lateral sclerosis","volume":"68","author":"Trias","year":"2020","journal-title":"Glia"},{"issue":"01","key":"10.1016\/bs.apcsb.2023.02.016_bib74","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/21678421.2013.778554","article-title":"Mechanisms, models and biomarkers in amyotrophic lateral sclerosis","volume":"14","author":"Turner","year":"2013","journal-title":"Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.02.016_bib75","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1471-4159.2007.04764.x","article-title":"Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation","volume":"103","author":"Uversky","year":"2007","journal-title":"Journal of Neurochemistry"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.02.016_bib76","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1086\/319522","article-title":"Localization of a novel locus for autosomal recessive early-onset parkinsonism, PARK6, on human chromosome 1p35-p36","volume":"68","author":"Valente","year":"2001","journal-title":"American Journal of Human Genetics"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.02.016_bib77","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/nan.12559","article-title":"Expression of p16 and p21 in the frontal association cortex of ALS\/MND brains suggests neuronal cell cycle dysregulation and astrocyte senescence in early stages of the disease","volume":"46","author":"Vazquez-Villase\u00f1or","year":"2020","journal-title":"Neuropathology and Applied Neurobiology"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.02.016_bib78","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S1535-6108(03)00223-X","article-title":"The tumor-suppressive functions of the human INK4A locus","volume":"4","author":"Voorhoeve","year":"2003","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.02.016_bib79","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13024-020-00376-6","article-title":"Mitochondria dysfunction in the pathogenesis of Alzheimer\u2019s disease: Recent advances","volume":"15","author":"Wang","year":"2020","journal-title":"Molecular Neurodegeneration"},{"issue":"6929","key":"10.1016\/bs.apcsb.2023.02.016_bib80","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature01470","article-title":"Antibody neutralization and escape by HIV-1","volume":"422","author":"Wei","year":"2003","journal-title":"Nature"},{"issue":"15","key":"10.1016\/bs.apcsb.2023.02.016_bib81","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.4103\/0366-6999.186646","article-title":"Amyloid \u03b2 protein aggravates neuronal senescence and cognitive deficits in 5XFAD mouse model of Alzheimer\u2019s disease","volume":"129","author":"Wei","year":"2016","journal-title":"Chinese Medical Journal"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.02.016_bib82","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1750-1326-3-15","article-title":"Evaluation of dimebon in cellular model of Huntington\u2019s disease","volume":"3","author":"Wu","year":"2008","journal-title":"Molecular Neurodegeneration"},{"issue":"6","key":"10.1016\/bs.apcsb.2023.02.016_bib83","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/nm0602-600","article-title":"Dopamine-dependent neurotoxicity of alpha-synuclein: A\u00a0mechanism for selective neurodegeneration in Parkinson disease","volume":"8","author":"Xu","year":"2002","journal-title":"Nature Medicine"},{"key":"10.1016\/bs.apcsb.2023.02.016_bib84","first-page":"12","article-title":"Genetically predicted telomere length and its relationship with Alzheimer\u2019s disease","author":"Yu","year":"2021","journal-title":"Frontiers in Genetics"},{"issue":"15","key":"10.1016\/bs.apcsb.2023.02.016_bib85","doi-asserted-by":"crossref","DOI":"10.1172\/JCI158450","article-title":"Cellular senescence: A key therapeutic target in aging and diseases","volume":"132","author":"Zhang","year":"2022","journal-title":"The Journal of Clinical Investigation"},{"issue":"5","key":"10.1016\/bs.apcsb.2023.02.016_bib86","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/s41593-019-0372-9","article-title":"Senolytic therapy alleviates A\u03b2-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer\u2019s disease model","volume":"22","author":"Zhang","year":"2019","journal-title":"Nature Neuroscience"},{"issue":"3","key":"10.1016\/bs.apcsb.2023.02.016_bib87","doi-asserted-by":"crossref","first-page":"202","DOI":"10.2174\/1874467212666181127151059","article-title":"Mitochondria-targeted drugs","volume":"12","author":"Zinovkin","year":"2018","journal-title":"Current Molecular Pharmacology"}],"container-title":["Advances in Protein Chemistry and Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876162323000378?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876162323000378?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T07:03:27Z","timestamp":1698649407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876162323000378"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9780443188862"],"references-count":87,"URL":"https:\/\/doi.org\/10.1016\/bs.apcsb.2023.02.016","relation":{},"ISSN":["1876-1623"],"issn-type":[{"value":"1876-1623","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}