{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T21:54:12Z","timestamp":1743026052326,"version":"3.40.3"},"reference-count":85,"publisher":"Elsevier","isbn-type":[{"type":"print","value":"9780443193460"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/bs.apcsb.2023.12.011","type":"book-chapter","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T11:28:28Z","timestamp":1720092508000},"page":"367-396","source":"Crossref","is-referenced-by-count":1,"title":["Biomarker identification of medullary thyroid carcinoma from gene expression profiles considering without-treatment and with-treatment studies\u2014A bioinformatics approach"],"prefix":"10.1016","author":[{"given":"Tamizhini","family":"Loganathan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"George Priya Doss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/bs.apcsb.2023.12.011_bib1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2174\/138920207782446160","article-title":"The phosphoinositide 3-kinase pathway in human cancer: genetic alterations and therapeutic implications","volume":"8","author":"Arcaro","year":"2007","journal-title":"Current Genomics"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.011_bib2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1471-2105-4-2","article-title":"An automated method for finding molecular complexes in large protein interaction networks","volume":"4","author":"Bader","year":"2003","journal-title":"BMC Bioinformatics"},{"issue":"D1","key":"10.1016\/bs.apcsb.2023.12.011_bib3","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: Archive for functional genomics data sets\u2014Update","volume":"41","author":"Barrett","year":"2012","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.011_bib4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society: Series B (Methodological)"},{"issue":"12","key":"10.1016\/bs.apcsb.2023.12.011_bib5","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1210\/jcem.86.12.8070","article-title":"COnsensus: Guidelines for diagnosis and therapy of MEN type 1 and type 2","volume":"86","author":"Brandi","year":"2001","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"issue":"11","key":"10.1016\/bs.apcsb.2023.12.011_bib6","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1089\/thy.2018.0314","article-title":"ETS factor ETV5 activates the mutant telomerase reverse transcriptase promoter in thyroid cancer","volume":"29","author":"Bullock","year":"2019","journal-title":"Thyroid: Official Journal of the American Thyroid Association"},{"issue":"11","key":"10.1016\/bs.apcsb.2023.12.011_bib7","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nrc1997","article-title":"MicroRNA signatures in human cancers","volume":"6","author":"Calin","year":"2006","journal-title":"Nature Reviews. Cancer"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.011_bib8","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2105-14-128","article-title":"Enrichr: Interactive and collaborative HTML5 gene list enrichment analysis tool","volume":"14","author":"Chen","year":"2013","journal-title":"BMC Bioinformatics"},{"issue":"Suppl 4","key":"10.1016\/bs.apcsb.2023.12.011_bib9","article-title":"cytoHubba: Identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Systems Biology"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.12.011_bib10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1677\/JOE-06-0193","article-title":"Expression and role of estrogen receptor alpha and beta in medullary thyroid carcinoma: Different roles in cancer growth and apoptosis","volume":"195","author":"Cho","year":"2007","journal-title":"The Journal of Endocrinology"},{"issue":"5","key":"10.1016\/bs.apcsb.2023.12.011_bib11","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/SLA.0b013e31813e66b9","article-title":"Long-term clinical and biochemical follow-up in medullary thyroid carcinoma","volume":"246","author":"Cupisti","year":"2007","journal-title":"Annals of Surgery"},{"key":"10.1016\/bs.apcsb.2023.12.011_bib12","doi-asserted-by":"crossref","DOI":"10.20471\/acc.2020.59.s1.06","article-title":"Medullary thyroid cancer \u2013 Feature review and update on systemic treatment","author":"Dabeli\u0107","year":"2020","journal-title":"Acta Clinica Croatica"},{"issue":"14","key":"10.1016\/bs.apcsb.2023.12.011_bib13","first-page":"1846","article-title":"GEOquery: A bridge between the gene expression omnibus (GEO) and BioConductor","volume":"23","author":"Davis","year":"2007","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"5","key":"10.1016\/bs.apcsb.2023.12.011_bib14","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1210\/er.2006-0017","article-title":"RET as a diagnostic and therapeutic target in sporadic and hereditary endocrine tumors","volume":"27","author":"de Groot","year":"2006","journal-title":"Endocrine Reviews"},{"issue":"6","key":"10.1016\/bs.apcsb.2023.12.011_bib15","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1111\/j.1365-2265.2006.02659.x","article-title":"Determinants of life expectancy in medullary thyroid cancer: Age does not matter","volume":"65","author":"de Groot","year":"2006","journal-title":"Clinical Endocrinology"},{"key":"10.1016\/bs.apcsb.2023.12.011_bib16","first-page":"163","article-title":"Targeting apoptosis to overcome chemotherapy resistance","author":"Eda Dogan","year":"2022","journal-title":"Exon Publications"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.12.011_bib17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1159\/000346174","article-title":"2012 European thyroid association guidelines for genetic testing and its clinical consequences in medullary thyroid cancer","volume":"1","author":"Elisei","year":"2012","journal-title":"European Thyroid Journal"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.12.011_bib18","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: A review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicologic Pathology"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.12.011_bib19","doi-asserted-by":"crossref","first-page":"955","DOI":"10.3390\/cells10040955","article-title":"MicroRNAs in medullary thyroid carcinoma: A state of the art review of the regulatory mechanisms and future perspectives","volume":"10","author":"Galuppini","year":"2021","journal-title":"Cells"},{"key":"10.1016\/bs.apcsb.2023.12.011_bib20","article-title":"The neurotrophic tyrosine kinase receptor TrkA and its ligand NGF are increased in squamous cell carcinomas of the lung","volume":"8","author":"Gao","year":"2018","journal-title":"Scientific Reports"},{"issue":"8","key":"10.1016\/bs.apcsb.2023.12.011_bib21","first-page":"2628","article-title":"ShinyGO: A graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2019","journal-title":"Bioinformatics (Oxford, England)"},{"issue":"90001","key":"10.1016\/bs.apcsb.2023.12.011_bib22","first-page":"258D261","article-title":"The gene ontology (GO) database and informatics resource","volume":"32","year":"2004","journal-title":"Nucleic Acids Research"},{"issue":"5","key":"10.1016\/bs.apcsb.2023.12.011_bib23","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1530\/ERC-13-0085","article-title":"Targeting mTOR in RET mutant medullary and differentiated thyroid cancer cells","volume":"20","author":"Gild","year":"2013","journal-title":"Endocrine-Related Cancer"},{"key":"10.1016\/bs.apcsb.2023.12.011_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4061\/2011\/815826","article-title":"Medullary thyroid carcinoma: Molecular signaling pathways and emerging therapies","volume":"2011","author":"G\u00f3mez","year":"2011","journal-title":"Journal of Thyroid Research"},{"issue":"3","key":"10.1016\/bs.apcsb.2023.12.011_bib25","doi-asserted-by":"crossref","first-page":"e1104","DOI":"10.1038\/cddis.2014.78","article-title":"Blocks to thyroid cancer cell apoptosis can be overcome by inhibition of the MAPK and PI3K\/AKT pathways","volume":"5","author":"Gunda","year":"2014","journal-title":"Cell Death & Disease"},{"issue":"3","key":"10.1016\/bs.apcsb.2023.12.011_bib26","article-title":"ERK\/MAPK signalling pathway and tumorigenesis (review)","volume":"19","author":"Guo","year":"2020","journal-title":"Experimental and Therapeutic Medicine"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.011_bib27","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1146\/annurev.neuro.24.1.677","article-title":"Neurotrophins: Roles in neuronal development and function","volume":"24","author":"Huang","year":"2001","journal-title":"Annual Review of Neuroscience"},{"issue":"D1","key":"10.1016\/bs.apcsb.2023.12.011_bib28","doi-asserted-by":"crossref","first-page":"D222","DOI":"10.1093\/nar\/gkab1079","article-title":"miRTarBase update 2022: An informative resource for experimentally validated miRNA\u2013target interactions","volume":"50","author":"Huang","year":"2021","journal-title":"Nucleic Acids Research"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.12.011_bib29","doi-asserted-by":"crossref","first-page":"284","DOI":"10.14740\/jocmr2480w","article-title":"Signaling pathways in thyroid cancer and their therapeutic implications","volume":"8","author":"Jin","year":"2016","journal-title":"Journal of Clinical Medicine Research"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.011_bib30","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Research"},{"issue":"5","key":"10.1016\/bs.apcsb.2023.12.011_bib31","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1139::AID-CNCR26>3.0.CO;2-Z","article-title":"Medullary thyroid carcinoma","volume":"88","author":"Kebebew","year":"2000","journal-title":"Cancer"},{"issue":"W1","key":"10.1016\/bs.apcsb.2023.12.011_bib32","doi-asserted-by":"crossref","first-page":"W521","DOI":"10.1093\/nar\/gkaa309","article-title":"miEAA 2.0: Integrating multi-species microRNA enrichment analysis and workflow management systems","volume":"48","author":"Kern","year":"2020","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/bs.apcsb.2023.12.011_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4061\/2011\/710213","article-title":"Thyroid-specific transcription factors and their roles in thyroid cancer","volume":"2011","author":"Kimura","year":"2011","journal-title":"Journal of Thyroid Research"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.12.011_bib34","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ceb.2009.01.013","article-title":"Role of MAPK pathway oncoproteins in thyroid cancer pathogenesis and as drug targets","volume":"21","author":"Knauf","year":"2009","journal-title":"Current Opinion in Cell Biology"},{"issue":"6","key":"10.1016\/bs.apcsb.2023.12.011_bib35","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.surg.2006.06.040","article-title":"Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002","volume":"140","author":"Kunnimalaiyaan","year":"2006","journal-title":"Surgery"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.12.011_bib36","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3390\/cells9040830","article-title":"Combinatorial therapies in thyroid cancer: An overview of preclinical and clinical progresses","volume":"9","author":"Laetitia","year":"2020","journal-title":"Cells"},{"issue":"9","key":"10.1016\/bs.apcsb.2023.12.011_bib37","doi-asserted-by":"crossref","first-page":"e1000637","DOI":"10.1371\/journal.pgen.1000637","article-title":"The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1\/USF2 transcription factors","volume":"5","author":"Landa","year":"2009","journal-title":"PLoS Genetics"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.011_bib38","article-title":"ExpressAnalyst: A unified platform for RNA-sequencing Analysis in non-model species","volume":"14","author":"Liu","year":"2023","journal-title":"Nature Communications"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.011_bib39","doi-asserted-by":"crossref","DOI":"10.1186\/s12943-018-0793-1","article-title":"EGFR-TKIs resistance via EGFR-independent signaling pathways","volume":"17","author":"Liu","year":"2018","journal-title":"Molecular Cancer"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.12.011_bib40","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s12020-014-0380-1","article-title":"PI3K\/Akt\/mTOR signaling in medullary thyroid cancer: A promising molecular target for cancer therapy","volume":"48","author":"Manfredi","year":"2014","journal-title":"Endocrine"},{"issue":"5","key":"10.1016\/bs.apcsb.2023.12.011_bib41","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrc1610","article-title":"Molecular genetics of multiple endocrine neoplasia types 1 and 2","volume":"5","author":"Marx","year":"2005","journal-title":"Nature Reviews. Cancer"},{"issue":"8","key":"10.1016\/bs.apcsb.2023.12.011_bib42","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.bbamcr.2006.10.001","article-title":"Roles of the Raf\/MEK\/ERK pathway in cell growth, malignant transformation and drug resistance","volume":"1773","author":"McCubrey","year":"2007","journal-title":"Biochimica et Biophysica Acta (BBA)\u2014Molecular Cell Research"},{"issue":"8","key":"10.1016\/bs.apcsb.2023.12.011_bib43","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.1073\/pnas.96.8.4540","article-title":"Roles of trk family neurotrophin receptors in medullary thyroid carcinoma development and progression","volume":"96","author":"McGregor","year":"1999","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.apcsb.2023.12.011_bib44","unstructured":"Medullary Thyroid Carcinoma Treatment in India | Healing Touristry. (n.d.). Www.healingtouristry.com. Retrieved September 13, 2023, from https:\/\/www.healingtouristry.com\/specialities-detail\/medullary-thyroid-carcinoma-treatment."},{"key":"10.1016\/bs.apcsb.2023.12.011_bib79","unstructured":"Medscape.\u00a0(2022).\u00a0Thyroid cancer staging: TNM classification for thyroid cancer. EMedicine. https:\/\/emedicine.medscape.com\/article\/2006643-overview."},{"issue":"8","key":"10.1016\/bs.apcsb.2023.12.011_bib45","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.3390\/cancers14081951","article-title":"Medullary thyroid carcinoma mutational spectrum update and signaling-type inference by transcriptional profiles: Literature meta-analysis and study of tumor samples","volume":"14","author":"Minna","year":"2022","journal-title":"Cancers"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.12.011_bib46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/diseases6020025","article-title":"ERBB1- and ERBB2-positive medullary thyroid carcinoma: A case report","volume":"6","author":"Minuto","year":"2018","journal-title":"Diseases"},{"issue":"30","key":"10.1016\/bs.apcsb.2023.12.011_bib47","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"3","key":"10.1016\/bs.apcsb.2023.12.011_bib48","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1046\/j.1365-2265.1998.00392.x","article-title":"Prognostic factors for survival and for biochemical cure in medullary thyroid carcinoma: Results in 899 patients","volume":"48","author":"Modigliani","year":"1998","journal-title":"Clinical Endocrinology"},{"issue":"5","key":"10.1016\/bs.apcsb.2023.12.011_bib49","doi-asserted-by":"crossref","first-page":"R235","DOI":"10.1530\/ERC-15-0070","article-title":"RAS proto-oncogene in medullary thyroid carcinoma","volume":"22","author":"Moura","year":"2015","journal-title":"Endocrine-Related Cancer"},{"issue":"11","key":"10.1016\/bs.apcsb.2023.12.011_bib50","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1038\/sj.bjc.6605056","article-title":"Correlation of RET somatic mutations with clinicopathological features in sporadic medullary thyroid carcinomas","volume":"100","author":"Moura","year":"2009","journal-title":"British Journal of Cancer"},{"key":"10.1016\/bs.apcsb.2023.12.011_bib51","article-title":"GDNF and the RET receptor in cancer: New insights and therapeutic potential","volume":"9","author":"Mulligan","year":"2018","journal-title":"Frontiers in Physiology"},{"issue":"S2","key":"10.1016\/bs.apcsb.2023.12.011_bib52","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1038\/modpathol.2008.10","article-title":"Thyroid carcinoma: Molecular pathways and therapeutic targets","volume":"21","author":"Nikiforov","year":"2008","journal-title":"Modern Pathology"},{"key":"10.1016\/bs.apcsb.2023.12.011_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.708949","article-title":"Update on targeted therapy in medullary thyroid cancer","volume":"12","author":"Okafor","year":"2021","journal-title":"Frontiers in Endocrinology"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.12.011_bib54","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ejso.2006.10.021","article-title":"Natural history, diagnosis, treatment and outcome of medullary thyroid cancer: 37 years experience on 157 patients","volume":"33","author":"Pelizzo","year":"2007","journal-title":"Ejso"},{"issue":"D1","key":"10.1016\/bs.apcsb.2023.12.011_bib55","article-title":"The DisGeNET knowledge platform for disease genomics: 2019 update","volume":"48","author":"Pi\u00f1ero","year":"2019","journal-title":"Nucleic Acids Research"},{"issue":"5","key":"10.1016\/bs.apcsb.2023.12.011_bib56","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.surg.2008.06.028","article-title":"The phosphatidylinositol 3-kinase\/akt signaling pathway in medullary thyroid cancer","volume":"144","author":"Pitt","year":"2008","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.12.011_bib57","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.3390\/ijms13021886","article-title":"The mTOR signalling pathway in human cancer","volume":"13","author":"P\u00f3pulo","year":"2012","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/bs.apcsb.2023.12.011_bib58","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.985363","article-title":"The role of BCL-2 family proteins in regulating apoptosis and cancer therapy","volume":"12","author":"Qian","year":"2022","journal-title":"Frontiers in Oncology"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.12.011_bib59","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.biopha.2011.11.010","article-title":"Estrogen activity as a preventive and therapeutic target in thyroid cancer","volume":"66","author":"Rajoria","year":"2012","journal-title":"Biomedicine & Pharmacotherapy"},{"issue":"1473","key":"10.1016\/bs.apcsb.2023.12.011_bib60","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1098\/rstb.2006.1894","article-title":"Neurotrophin-regulated signalling pathways","volume":"361","author":"Reichardt","year":"2006","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.12.011_bib61","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/08998280.2016.11929421","article-title":"Thyroid hormone resistance and its management","volume":"29","author":"Rivas","year":"2016","journal-title":"Proceedings (Baylor University. Medical Center)"},{"key":"10.1016\/bs.apcsb.2023.12.011_bib62","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2015.00188","article-title":"The PI3K\/Akt pathway in tumors of endocrine tissues","volume":"6","author":"Robbins","year":"2016","journal-title":"Frontiers in Endocrinology"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.011_bib63","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1677\/ERC-08-0304","article-title":"Overexpression and activation of EGFR and VEGFR2 in medullary thyroid carcinomas is related to metastasis","volume":"17","author":"Rodr\u00edguez-Antona","year":"2010","journal-title":"Endocrine-Related Cancer"},{"issue":"9","key":"10.1016\/bs.apcsb.2023.12.011_bib64","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1002\/cncr.22244","article-title":"Prognosis of medullary thyroid carcinoma","volume":"107","author":"Roman","year":"2006","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/bs.apcsb.2023.12.011_bib65","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1530\/ERC-17-0389","article-title":"Circulating miR-375 as a novel prognostic marker for metastatic medullary thyroid cancer patients","volume":"25","author":"Romeo","year":"2018","journal-title":"Endocrine-Related Cancer"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.011_bib66","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1517\/14728222.2011.645805","article-title":"Targeting the MAPK\u2013RAS\u2013RAF signaling pathway in cancer therapy","volume":"16","author":"Santarpia","year":"2012","journal-title":"Expert Opinion on Therapeutic Targets"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.011_bib67","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1365-2796.2009.02112.x","article-title":"Beyond RET: Potential therapeutic approaches for advanced and metastatic medullary thyroid carcinoma","volume":"266","author":"Santarpia","year":"2009","journal-title":"Journal of Internal Medicine"},{"key":"10.1016\/bs.apcsb.2023.12.011_bib68","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/348124","article-title":"Beneficial effects of the mTOR inhibitor everolimus in patients with advanced medullary thyroid carcinoma: Subgroup results of a phase II trial","volume":"2015","author":"Schneider","year":"2015","journal-title":"International Journal of Endocrinology"},{"issue":"3","key":"10.1016\/bs.apcsb.2023.12.011_bib69","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3390\/cancers15030710","article-title":"MAPK pathway inhibitors in thyroid cancer: Preclinical and clinical data","volume":"15","author":"Schubert","year":"2023","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/bs.apcsb.2023.12.011_bib70","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrclinonc.2014.5","article-title":"Clinical relevance of circulating cell-free microRNAs in cancer","volume":"11","author":"Schwarzenbach","year":"2014","journal-title":"Nature Reviews Clinical Oncology"},{"issue":"11","key":"10.1016\/bs.apcsb.2023.12.011_bib71","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Research"},{"issue":"7","key":"10.1016\/bs.apcsb.2023.12.011_bib72","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.3390\/ijms21072531","article-title":"Current insights into combination therapies with MAPK inhibitors and immune checkpoint blockade","volume":"21","author":"Shin","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.011_bib73","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cell.2017.06.009","article-title":"RAS proteins and their regulators in human disease","volume":"170","author":"Simanshu","year":"2017","journal-title":"Cell"},{"key":"10.1016\/bs.apcsb.2023.12.011_bib74","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/0-387-29362-0_23","article-title":"limma: Linear models for microarray data","author":"Smyth","year":"2005","journal-title":"Bioinformatics and Computational Biology Solutions Using R and Bioconductor"},{"key":"10.1016\/bs.apcsb.2023.12.011_bib75","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein\u2013protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Research"},{"issue":"13","key":"10.1016\/bs.apcsb.2023.12.011_bib76","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1158\/1078-0432.CCR-11-2700","article-title":"Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases","volume":"18","author":"Tamburrino","year":"2012","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.011_bib77","article-title":"Thyroid nodule update on diagnosis and management","volume":"2","author":"Tamhane","year":"2016","journal-title":"Clinical Diabetes and Endocrinology"},{"issue":"5","key":"10.1016\/bs.apcsb.2023.12.011_bib78","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.3390\/ijms19051448","article-title":"mTOR pathway in papillary thyroid carcinoma: Different contributions of mTORC1 and mTORC2 complexes for tumor behavior and SLC5A5 mRNA expression","volume":"19","author":"Tavares","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"issue":"16","key":"10.1016\/bs.apcsb.2023.12.011_bib80","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.122225","article-title":"Transcriptional targeting of oncogene addiction in medullary thyroid cancer","volume":"3","author":"Valenciaga","year":"2018","journal-title":"JCI Insight"},{"issue":"6a","key":"10.1016\/bs.apcsb.2023.12.011_bib81","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1111\/j.1582-4934.2008.00427.x","article-title":"Pax genes in embryogenesis and oncogenesis","volume":"12","author":"Wang","year":"2008","journal-title":"Journal of Cellular and Molecular Medicine"},{"issue":"10","key":"10.1016\/bs.apcsb.2023.12.011_bib82","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1007\/s00018-008-7440-8","article-title":"The epidermal growth factor receptor family: Biology driving targeted therapeutics","volume":"65","author":"Wieduwilt","year":"2008","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"41","key":"10.1016\/bs.apcsb.2023.12.011_bib83","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.20311","article-title":"The resistance mechanisms and treatment strategies for EGFR-mutant advanced non-small-cell lung cancer","volume":"8","author":"Zhong","year":"2017","journal-title":"Oncotarget"},{"issue":"W1","key":"10.1016\/bs.apcsb.2023.12.011_bib84","doi-asserted-by":"crossref","first-page":"W234","DOI":"10.1093\/nar\/gkz240","article-title":"NetworkAnalyst 3.0: A visual analytics platform for comprehensive gene expression profiling and meta-analysis","volume":"47","author":"Zhou","year":"2019","journal-title":"Nucleic Acids Research"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.011_bib85","doi-asserted-by":"crossref","DOI":"10.1186\/s13578-020-00396-1","article-title":"mTOR signaling pathway and mTOR inhibitors in cancer: Progress and challenges","volume":"10","author":"Zou","year":"2020","journal-title":"Cell & Bioscience"}],"container-title":["Advances in Protein Chemistry and Structural Biology","Hormones"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876162323001232?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876162323001232?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T06:06:56Z","timestamp":1721887616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876162323001232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9780443193460"],"references-count":85,"URL":"https:\/\/doi.org\/10.1016\/bs.apcsb.2023.12.011","relation":{},"ISSN":["1876-1623"],"issn-type":[{"type":"print","value":"1876-1623"}],"subject":[],"published":{"date-parts":[[2024]]}}}