{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T10:45:19Z","timestamp":1772966719445,"version":"3.50.1"},"reference-count":42,"publisher":"Elsevier","isbn-type":[{"value":"9780443193446","type":"print"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/bs.apcsb.2023.12.018","type":"book-chapter","created":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T16:35:46Z","timestamp":1716827746000},"page":"1-21","source":"Crossref","is-referenced-by-count":1,"title":["Transcriptomic analysis reveals zinc-mediated virulence and pathogenicity in multidrug-resistant Acinetobacter baumannii"],"prefix":"10.1016","member":"78","reference":[{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.018_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1021\/acsinfecdis.9b00351","article-title":"The role of zinc efflux during Acinetobacter baumannii infection","volume":"6","author":"Alquethamy","year":"2020","journal-title":"ACS Infectious Diseases"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib2","first-page":"657","article-title":"Genetic tools for manipulating Acinetobacter baumannii genome: An overview","volume":"64","author":"Biswas","year":"2015"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.12.018_bib3","doi-asserted-by":"crossref","first-page":"727","DOI":"10.3201\/eid2404.171461","article-title":"Carbapenem-nonsusceptible acinetobacter baumannii, 8 US metropolitan areas, 2012\u20132015","volume":"24","author":"Bulens","year":"2018","journal-title":"Emerging Infectious Diseases"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib4","first-page":"4037","article-title":"Genetic mechanisms of antibiotic resistance and virulence in Acinetobacter baumannii: Background, challenges and future prospects","volume":"47","author":"Chakravarty","year":"2020"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.12.018_bib5","article-title":"cytoHubba: Identifying hub objects and sub-networks from complex interactome","volume":"8","author":"Chin","year":"2014","journal-title":"BMC Systems Biology"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib6","author":"De Oliveira","year":"2020","journal-title":"Antimicrobial Resistance in ESKAPE Pathogens"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.12.018_bib7","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1021\/acs.jproteome.8b00702","article-title":"Cytoscape StringApp: Network analysis and visualization of proteomics data","volume":"18","author":"Doncheva","year":"2019","journal-title":"Journal of Proteome Research"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib8","unstructured":"Ewels, P., Magnusson, M., Lundin, S., & K\u00e4ller, M. Data and text mining MultiQC: Summarize analysis results for multiple tools and samples in a single report. [Online]. Available: http:\/\/www.bioinformatics.babraham.ac.uk\/projects\/fastqc."},{"issue":"48","key":"10.1016\/bs.apcsb.2023.12.018_bib9","doi-asserted-by":"crossref","first-page":"47602","DOI":"10.1074\/jbc.M308967200","article-title":"Iron-sulfur cluster N2 of the Escherichia coli NADH: Ubiquinone oxidoreductase (complex I) is located on subunit NuoB","volume":"278","author":"Flemming","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib10","doi-asserted-by":"crossref","unstructured":"Fournier, P. E., & Richet , H. (2006). The epidemiology and control of Acinetobacter baumannii in health care facilities. [Online]. Available: http:\/\/cid.oxfordjournals.org\/.","DOI":"10.1086\/500202"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.018_bib11","doi-asserted-by":"crossref","DOI":"10.1080\/21505594.2023.2187025","article-title":"Role of riboflavin biosynthesis gene duplication and transporter in Aeromonas salmonicida virulence in marine teleost fish","volume":"14","author":"Gnanagobal","year":"2023","journal-title":"Virulence"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.018_bib12","article-title":"Unipro UGENE NGS pipelines and components for variant calling, RNA-seq and ChIP-seq data analyses","volume":"2014","author":"Golosova","year":"2014","journal-title":"PeerJ"},{"issue":"15","key":"10.1016\/bs.apcsb.2023.12.018_bib13","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000025553","article-title":"Identification and analysis of key genes associated with acute myocardial infarction by integrated bioinformatics methods","volume":"100","author":"Guo","year":"2021","journal-title":"Medicine"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.12.018_bib14","first-page":"264","article-title":"Transcription of Corynebacterium glutamicum genes involved in tricarboxylic acid cycle and glyoxylate cycle","volume":"15","author":"Han","year":"2008","journal-title":"Journal of Molecular Microbiology and Biotechnology"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib15","first-page":"91","article-title":"Uncovering the mechanisms of Acinetobacter baumannii virulence","volume":"16","author":"Harding","year":"2018"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib16","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4248\/IJOS11026","article-title":"The clinical impact of bacterial biofilms","volume":"3","author":"H\u00f8iby","year":"2011","journal-title":"International Journal of Oral Science"},{"issue":"11","key":"10.1016\/bs.apcsb.2023.12.018_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0259436","article-title":"Bioinformatics analysis of genes related to iron death in diabetic nephropathy through network and pathway levels based approaches","volume":"16","author":"Hu","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib18","first-page":"6987","article-title":"Multidrug-resistant Acinetobacter baumannii as an emerging concern in hospitals","volume":"48","author":"Ibrahim","year":"2021"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.018_bib19","doi-asserted-by":"crossref","DOI":"10.1186\/s40560-015-0077-4","article-title":"Prognostic factors associated with mortality of drug-resistant Acinetobacter baumannii ventilator-associated pneumonia","volume":"3","author":"Inchai","year":"2015","journal-title":"Journal of Intensive Care"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib20","doi-asserted-by":"crossref","unstructured":"Janjic, A., et al. Prime-seq, efficient and powerful bulk RNA-sequencing. https:\/\/doi.org\/10.1101\/2021.09.27.459575.","DOI":"10.1101\/2021.09.27.459575"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib21","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ymben.2021.07.014","article-title":"Model-guided dynamic control of essential metabolic nodes boosts acetyl-coenzyme A\u2013dependent bioproduction in rewired Pseudomonas putida","volume":"67","author":"Kozaeva","year":"2021","journal-title":"Metabolic Engineering"},{"issue":"8","key":"10.1016\/bs.apcsb.2023.12.018_bib22","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1016\/j.celrep.2019.01.089","article-title":"An Acinetobacter baumannii, zinc-regulated peptidase maintains cell wall integrity during immune-mediated nutrient sequestration","volume":"26","author":"Lonergan","year":"2019","journal-title":"Cell Reports"},{"issue":"6","key":"10.1016\/bs.apcsb.2023.12.018_bib23","article-title":"Mapping global prevalence of acinetobacter baumannii and recent vaccine development to tackle it","volume":"9","author":"Ma","year":"2021","journal-title":"Vaccines (Basel)"},{"issue":"1","key":"10.1016\/bs.apcsb.2023.12.018_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-53847-2","article-title":"Human pleural fluid triggers global changes in the transcriptional landscape of Acinetobacter baumannii as an adaptive response to stress","volume":"9","author":"Martinez","year":"2019","journal-title":"Scientific Reports"},{"issue":"2","key":"10.1016\/bs.apcsb.2023.12.018_bib25","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1574-6976.2012.00344.x","article-title":"Acinetobacter baumannii: Human infections, factors contributing to pathogenesis and animal models","volume":"37","author":"McConnell","year":"2013","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/bs.apcsb.2023.12.018_bib26","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1093\/infdis\/jiw529","article-title":"Global gene expression profile of Acinetobacter baumannii during bacteremia","volume":"215","author":"Murray","year":"2017","journal-title":"Journal of Infectious Diseases"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib27","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2164-15-S10-S5","article-title":"TIGAR2: Sensitive and accurate estimation of transcript isoform expression with longer RNA-Seq reads","volume":"15","author":"Nariai","year":"2014","journal-title":"BMC Genomics"},{"issue":"6","key":"10.1016\/bs.apcsb.2023.12.018_bib28","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1101\/pdb.prot098368","article-title":"An RNA-seq protocol for differential expression analysis","volume":"2019","author":"Owens","year":"2019","journal-title":"Cold Spring Harbor Protocols"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib29","unstructured":"Pae, G., El Zelenetz, A. D.\u00a0& Tyler, B. M. gltB gene and regulation of nitrogen metabolism by glutamine synthetase in Escherichia coli. [Online]. Available: https:\/\/journals.asm.org\/journal\/jb."},{"issue":"3","key":"10.1016\/bs.apcsb.2023.12.018_bib30","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1128\/CMR.00058-07","article-title":"Acinetobacter baumannii: Emergence of a successful pathogen","volume":"21","author":"Peleg","year":"2008","journal-title":"Clinical Microbiology Reviews"},{"issue":"6","key":"10.1016\/bs.apcsb.2023.12.018_bib31","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00433-22","article-title":"Acinetobacter metabolism in infection and antimicrobial resistance","volume":"91","author":"Ren","year":"2023","journal-title":"Infection and Immunity"},{"issue":"11","key":"10.1016\/bs.apcsb.2023.12.018_bib32","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: A software Environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Research"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.12.018_bib33","first-page":"194","article-title":"Multi-perspective quality control of Illumina RNA sequencing data analysis","volume":"16","author":"Sheng","year":"2017","journal-title":"Brief Funct Genomics"},{"issue":"D1","key":"10.1016\/bs.apcsb.2023.12.018_bib34","doi-asserted-by":"crossref","first-page":"D605","DOI":"10.1093\/nar\/gkaa1074","article-title":"The STRING database in 2021: Customizable protein-protein networks, and functional characterization of user-uploaded gene\/measurement sets","volume":"49","author":"Szklarczyk","year":"2021","journal-title":"Nucleic Acids Research"},{"issue":"D1","key":"10.1016\/bs.apcsb.2023.12.018_bib35","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: Protein\u2013protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Research"},{"issue":"3","key":"10.1016\/bs.apcsb.2023.12.018_bib36","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/S1473-3099(17)30753-3","article-title":"Discovery, research, and development of new antibiotics: The WHO priority list of antibiotic-resistant bacteria and tuberculosis","volume":"18","author":"Tacconelli","year":"2018","journal-title":"The Lancet Infectious Diseases"},{"issue":"4","key":"10.1016\/bs.apcsb.2023.12.018_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.01313-14","article-title":"Defining gene-phenotype relationships in acinetobacter baumannii through one-step chromosomal gene inactivation","volume":"5","author":"Tucker","year":"2014","journal-title":"mBio"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.pep.2022.106134","article-title":"Recombinant AcnB, NrdR and RibD of Acinetobacter baumannii and their potential interaction with DNA adenine methyltransferase AamA","volume":"199","author":"Weber","year":"2022","journal-title":"Protein Expression and Purification"},{"issue":"3","key":"10.1016\/bs.apcsb.2023.12.018_bib39","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.jinf.2011.12.008","article-title":"Nosocomial bloodstream infections due to Acinetobacter baumannii, Acinetobacter pittii and Acinetobacter nosocomialis in the United States","volume":"64","author":"Wisplinghoff","year":"2012","journal-title":"Journal of Infection"},{"key":"#cr-split#-10.1016\/bs.apcsb.2023.12.018_bib40.1","doi-asserted-by":"crossref","unstructured":"Zhang , Q., et al. (2022).\u00a0Author correction: Identification of hub genes for adult patients with sepsis via RNA sequencing. Scientific Reports, 12(1), 5128. https:\/\/doi.org\/10.1038\/s41598-022-09175-z","DOI":"10.1038\/s41598-022-10297-7"},{"key":"#cr-split#-10.1016\/bs.apcsb.2023.12.018_bib40.2","doi-asserted-by":"crossref","unstructured":"Nature Research, Dec. 01, 2022. https:\/\/doi.org\/10.1038\/s41598-022-10297-7.","DOI":"10.1038\/s41598-022-10297-7"},{"key":"10.1016\/bs.apcsb.2023.12.018_bib41","article-title":"Identifying immune cell infiltration and effective diagnostic biomarkers in rheumatoid arthritis by bioinformatics analysis","volume":"12","author":"Zhou","year":"2021","journal-title":"Frontiers in Immunology"}],"container-title":["Advances in Protein Chemistry and Structural Biology","Metalloproteins and Motor Proteins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187616232300130X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S187616232300130X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T19:13:15Z","timestamp":1753729995000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S187616232300130X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9780443193446"],"references-count":42,"URL":"https:\/\/doi.org\/10.1016\/bs.apcsb.2023.12.018","relation":{},"ISSN":["1876-1623"],"issn-type":[{"value":"1876-1623","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}