{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:20:24Z","timestamp":1783758024188,"version":"3.55.0"},"reference-count":62,"publisher":"Elsevier","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/bs.apcsb.2024.08.004","type":"book-chapter","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T12:40:49Z","timestamp":1726231249000},"source":"Crossref","is-referenced-by-count":17,"title":["The cross-talk between ApoE and Tau protein in Alzheimer\u2019s disease"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-2129","authenticated-orcid":false,"given":"Subashchandrabose","family":"Chinnathambi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murugappan","family":"Kumarappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhura","family":"Chandrashekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/bs.apcsb.2024.08.004_bib1","doi-asserted-by":"crossref","first-page":"964","DOI":"10.18632\/aging.101203","article-title":"APOE \u03b54 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment\/Alzheimer\u2019s Disease","volume":"9","author":"Abdullah","year":"2017","journal-title":"Aging (Albany NY)"},{"issue":"24","key":"10.1016\/bs.apcsb.2024.08.004_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/cells11243994","article-title":"PICALM and Alzheimer\u2019s disease: An update and perspectives","volume":"11","author":"Ando","year":"2022","journal-title":"Cells"},{"issue":"2","key":"10.1016\/bs.apcsb.2024.08.004_bib3","doi-asserted-by":"crossref","first-page":"151202","DOI":"10.1016\/j.ejcb.2022.151202","article-title":"Inter-relationship of Histone Deacetylase-6 with Tau-cytoskeletal organization and remodeling","volume":"101","author":"Balmik","year":"2022","journal-title":"European Journal of Cell Biology"},{"issue":"1","key":"10.1016\/bs.apcsb.2024.08.004_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12964-021-00736-9","article-title":"The extracellular HDAC6 ZnF UBP domain modulates the actin network and post-translational modifications of Tau","volume":"19","author":"Balmik","year":"2021","journal-title":"Cell Communication and Signaling"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib5","series-title":"Alzheimer\u2019s disease research: What has guided research so far and why it is high time for a paradigm shift","first-page":"61","article-title":"Alzheimer\u2019s research goes deeper: Ultrastructural electron microscopy studies","author":"Behl","year":"2023"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib6","series-title":"Alzheimer\u2019s disease research: What has guided research so far and why it is high time for a paradigm shift","first-page":"575","article-title":"If you change the way you look at things, things you look at change","author":"Behl","year":"2023"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib7","series-title":"Alzheimer\u2019s disease research: What has guided research so far and why it is high time for a paradigm shift","article-title":"Thirty years after the launch of the amyloid cascade hypothesis: Is there a shift of gears at last?","author":"Behl","year":"2023"},{"issue":"24","key":"10.1016\/bs.apcsb.2024.08.004_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive review on Alzheimer\u2019s disease: Causes and treatment","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"2","key":"10.1016\/bs.apcsb.2024.08.004_bib9","doi-asserted-by":"crossref","first-page":"151201","DOI":"10.1016\/j.ejcb.2022.151201","article-title":"G-protein coupled purinergic P2Y12 receptor interacts and internalizes TauRD-mediated by membrane-associated actin cytoskeleton remodeling in microglia","volume":"101","author":"Chidambaram","year":"2022","journal-title":"European Journal of Cell Biology"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib10","series-title":"Alzheimer\u2019s Disease: Recent Findings in Pathophysiology, Diagnostic and Therapeutic Modalities","first-page":"137","article-title":"Aggregation Species of Amyloid-b and Tau Oligomers in Alzheimer\u2019s Disease: Role in Therapeutics and Diagnostics.","author":"Chinnathambi","year":"2022"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib11","article-title":"Alzheimer\u2019s disease pathology: A Tau perspective","volume":"58","author":"Chinnathambi","year":"2022","journal-title":"Alzheimer\u2019s Dis."},{"key":"10.1016\/bs.apcsb.2024.08.004_bib12","series-title":"Advances in Protein Chemistry and Structural Biology","article-title":"Nuclear transport protein suppresses Tau neurodegeneration","author":"Chinnathambi","year":"2024"},{"issue":"1","key":"10.1016\/bs.apcsb.2024.08.004_bib13","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13578-023-01028-0","article-title":"Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis","volume":"13","author":"Chinnathambi","year":"2023","journal-title":"Cell Biosci"},{"issue":"5","key":"10.1016\/bs.apcsb.2024.08.004_bib14","doi-asserted-by":"crossref","first-page":"119477","DOI":"10.1016\/j.bbamcr.2023.119477","article-title":"Tau aggregates improve the Purinergic receptor P2Y12-associated podosome rearrangements in microglial cells","volume":"1870","author":"Chinnathambi","year":"2023","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"issue":"2","key":"10.1016\/bs.apcsb.2024.08.004_bib15","article-title":"Dual modification of Tau by pseudophosphorylation and glycation does not enhance amorphous aggregation","volume":"58","author":"Chinnathambi","year":"2024","journal-title":"Cellular Physiology & Biochemistry (Cell Physiol Biochem Press GmbH & Co. KG)"},{"issue":"46","key":"10.1016\/bs.apcsb.2024.08.004_bib16","doi-asserted-by":"crossref","first-page":"27331","DOI":"10.1039\/D0RA03809A","article-title":"Residue-based propensity of aggregation in the Tau amyloidogenic hexapeptides AcPHF6\u204e and AcPHF6","volume":"10","author":"Dangi","year":"2020","journal-title":"RSC Advances"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib17","doi-asserted-by":"crossref","DOI":"10.1177\/1759091420981204","article-title":"Melatonin reduces GSK3\u03b2-mediated Tau phosphorylation, enhances Nrf2 nuclear translocation and anti-inflammation","volume":"12","author":"Das","year":"2020","journal-title":"ASN Neuro"},{"issue":"2","key":"10.1016\/bs.apcsb.2024.08.004_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0896-6273(03)00850-X","article-title":"ApoE and clusterin cooperatively suppress Abeta levels and deposition: Evidence that ApoE regulates extracellular Abeta metabolism in vivo","volume":"41","author":"DeMattos","year":"2004","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/bs.apcsb.2024.08.004_bib19","first-page":"17","article-title":"G-protein coupled receptor, PI3K and Rho signaling pathways regulate the cascades of Tau and amyloid-\u03b2 in Alzheimer\u2019s disease","volume":"2","author":"Desale","year":"2021","journal-title":"Molecular Medicine"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib20","series-title":"Tau protein: Methods and protocols","first-page":"471","article-title":"\u03b1-Linolenic acid induces microglial activation and extracellular Tau internalization","author":"Desale","year":"2024"},{"issue":"1","key":"10.1016\/bs.apcsb.2024.08.004_bib21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12974-020-01742-3","article-title":"Role of dietary fatty acids in microglial polarization in Alzheimer\u2019s disease","volume":"17","author":"Desale","year":"2020","journal-title":"Journal of neuroinflammation"},{"issue":"1","key":"10.1016\/bs.apcsb.2024.08.004_bib22","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12964-021-00715-0","article-title":"Phosphoinositides signaling modulates microglial actin remodeling and phagocytosis in Alzheimer\u2019s disease","volume":"19","author":"Desale","year":"2021","journal-title":"Cell Communication and Signaling"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib23","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ijbiomac.2020.10.226","article-title":"\u03b1-Linolenic acid inhibits Tau aggregation and modulates Tau conformation","volume":"166","author":"Desale","year":"2021","journal-title":"International Journal of Biological Macromolecules"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib24","doi-asserted-by":"crossref","unstructured":"Desale,\u00a0S. E., &\u00a0Chinnathambi,\u00a0S.\u00a0(2023).\u00a0Microtubule-dependent polarization and migration of microglia conserved by \u03b1-linolenic acid and extracellular Tau-mediated stimulation.\u00a0https:\/\/doi.org\/10.21203\/rs.3.rs-2695599\/v1.","DOI":"10.21203\/rs.3.rs-2695599\/v1"},{"issue":"38","key":"10.1016\/bs.apcsb.2024.08.004_bib25","doi-asserted-by":"crossref","first-page":"13909","DOI":"10.1073\/pnas.0404458101","article-title":"A nontransgenic mouse model shows inducible amyloid-beta (Abeta) peptide deposition and elucidates the role of apolipoprotein E in the amyloid cascade","volume":"101","author":"Dolev","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/bs.apcsb.2024.08.004_bib26","doi-asserted-by":"crossref","first-page":"12380","DOI":"10.1038\/s41598-020-69403-2","article-title":"Photodynamic exposure of Rose-Bengal inhibits Tau aggregation and modulates cytoskeletal network in neuronal cells","volume":"10","author":"Dubey","year":"2020","journal-title":"Scientific Reports"},{"issue":"3","key":"10.1016\/bs.apcsb.2024.08.004_bib27","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/nbdi.2002.0483","article-title":"Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer\u2019s disease","volume":"9","author":"Fagan","year":"2002","journal-title":"Neurobiology of Disease"},{"issue":"2","key":"10.1016\/bs.apcsb.2024.08.004_bib28","doi-asserted-by":"crossref","DOI":"10.3390\/cells8020182","article-title":"Apolipoprotein E4 alters astrocyte fatty acid metabolism and lipid droplet formation","volume":"8","author":"Farmer","year":"2019","journal-title":"Cells"},{"issue":"16","key":"10.1016\/bs.apcsb.2024.08.004_bib29","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA: The Journal of the American Medical Association"},{"issue":"1","key":"10.1016\/bs.apcsb.2024.08.004_bib30","first-page":"177","article-title":"Sleep and Alzheimer: The link","volume":"17","author":"Gaur","year":"2022","journal-title":"Maedica (Bucur)"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijbiomac.2020.02.278","article-title":"Cobalt-based metal complexes prevent Repeat Tau aggregation and nontoxic to neuronal cells","volume":"152","author":"Gorantla","year":"2020","journal-title":"International Journal of Biological Macromolecules"},{"issue":"3","key":"10.1016\/bs.apcsb.2024.08.004_bib32","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s12031-018-1174-3","article-title":"Tau protein squired by molecular chaperones during Alzheimer\u2019s disease","volume":"66","author":"Gorantla","year":"2018","journal-title":"Journal of Molecular Neuroscience: MN"},{"issue":"1","key":"10.1016\/bs.apcsb.2024.08.004_bib33","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3233\/ADR-190118","article-title":"Neem derivatives inhibits Tau aggregation","volume":"3","author":"Gorantla","year":"2019","journal-title":"Journal of Alzheimer\u2019s Disease Reports"},{"issue":"6","key":"10.1016\/bs.apcsb.2024.08.004_bib34","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1073\/pnas.050004797","article-title":"Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer\u2019s disease","volume":"97","author":"Holtzman","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"S2","key":"10.1016\/bs.apcsb.2024.08.004_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/alz.041052","article-title":"Impaired neuroinflammatory response of ApoE4 in Alzheimer\u2019s disease patients","volume":"16","author":"Kloske","year":"2020","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"10","key":"10.1016\/bs.apcsb.2024.08.004_bib36","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.molmed.2010.07.008","article-title":"APOE and cholesterol homeostasis in Alzheimer\u2019s disease","volume":"16","author":"Leduc","year":"2010","journal-title":"Trends in Molecular Medicine"},{"issue":"4","key":"10.1016\/bs.apcsb.2024.08.004_bib37","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1042\/BST0381021","article-title":"Links between ApoE, brain cholesterol metabolism, tau and amyloid beta-peptide in patients with cognitive impairment","volume":"38","author":"Leoni","year":"2010","journal-title":"Biochemical Society Transactions"},{"issue":"1","key":"10.1016\/bs.apcsb.2024.08.004_bib38","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/s13024-022-00542-y","article-title":"TREM2 in the pathogenesis of AD: A lipid metabolism regulator and potential metabolic therapeutic target","volume":"17","author":"Li","year":"2022","journal-title":"Molecular Neurodegeneration"},{"issue":"2","key":"10.1016\/bs.apcsb.2024.08.004_bib39","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: Risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nature Reviews Neurology"},{"issue":"15","key":"10.1016\/bs.apcsb.2024.08.004_bib40","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1073\/pnas.0600549103","article-title":"Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer\u2019s disease","volume":"103","author":"Mahley","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/bs.apcsb.2024.08.004_bib41","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s00018-022-04182-9","article-title":"The Alzheimer\u2019s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons","volume":"79","author":"Mishra","year":"2022","journal-title":"Cellular and Molecular Life Sciences: CMLS"},{"issue":"7","key":"10.1016\/bs.apcsb.2024.08.004_bib42","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.4103\/1673-5374.301013","article-title":"Clusterin: A multifaceted protein in the brain","volume":"16","author":"Moon","year":"2021","journal-title":"Neural Regeneration Research"},{"issue":"9","key":"10.1016\/bs.apcsb.2024.08.004_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21093165","article-title":"Type 3 diabetes and its role implications in Alzheimer\u2019s disease","volume":"21","author":"Nguyen","year":"2020","journal-title":"International Journal of Molecular Sciences"},{"issue":"10 Pt A","key":"10.1016\/bs.apcsb.2024.08.004_bib44","first-page":"1068","article-title":"Carriers of an apolipoprotein E epsilon 4 allele are more vulnerable to a dietary deficiency in omega-3 fatty acids and cognitive decline","volume":"1862","author":"Nock","year":"2017","journal-title":"Biochimica et Biophysica Acta (BBA)\u2014Molecular and Cell Biology of Lipids"},{"issue":"1","key":"10.1016\/bs.apcsb.2024.08.004_bib45","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0022-3956(01)00050-4","article-title":"24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia","volume":"36","author":"Papassotiropoulos","year":"2002","journal-title":"Journal of Psychiatric Research"},{"issue":"9","key":"10.1016\/bs.apcsb.2024.08.004_bib46","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/iub.1314","article-title":"Apolipoprotein E isoforms and lipoprotein metabolism","volume":"66","author":"Phillips","year":"2014","journal-title":"IUBMB Life"},{"issue":"1","key":"10.1016\/bs.apcsb.2024.08.004_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108572","article-title":"ApoE4 impairs neuron-astrocyte coupling of fatty acid metabolism","volume":"34","author":"Qi","year":"2021","journal-title":"Cell Reports"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib48","series-title":"Alzheimer\u2019s disease: Recent findings in pathophysiology, diagnostic and therapeutic modalities","first-page":"608","article-title":"Ethnic and racial differences in the pathophysiology of Alzheimer\u2019s disease","author":"Rekulapally","year":"2022"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib49","series-title":"Alzheimer\u2019s disease: Recent findings in pathophysiology, diagnostic and therapeutic modalities","first-page":"1","article-title":"Alzheimer\u2019s is a multifactorial disease","author":"Samanta","year":"2022"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib50","series-title":"Alzheimer\u2019s disease: Recent findings in pathophysiology, diagnostic and therapeutic modalities","first-page":"354","article-title":"The role of gut microbiome in Alzheimer\u2019s disease and therapeutic strategies","author":"Samanta","year":"2022"},{"issue":"10043","key":"10.1016\/bs.apcsb.2024.08.004_bib51","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","article-title":"Alzheimer\u2019s disease","volume":"388","author":"Scheltens","year":"2016","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/bs.apcsb.2024.08.004_bib52","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1194\/jlr.M700220-JLR200","article-title":"Remodeling of apolipoprotein E-containing spherical reconstituted high density lipoproteins by phospholipid transfer protein","volume":"49","author":"Settasatian","year":"2008","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib53","series-title":"Alzheimer\u2019s disease: Drug discovery","article-title":"Alzheimer\u2019s disease: Etiology, neuropathology and pathogenesis","author":"Sheppard","year":"2020"},{"issue":"1","key":"10.1016\/bs.apcsb.2024.08.004_bib54","doi-asserted-by":"crossref","first-page":"12579","DOI":"10.1038\/s41598-020-69429-6","article-title":"EGCG impedes human Tau aggregation and interacts with Tau","volume":"10","author":"Sonawane","year":"2020","journal-title":"Scientific Reports"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib55","series-title":"Alzheimer\u2019s disease: Recent findings in pathophysiology, diagnostic and therapeutic modalities","first-page":"58","article-title":"Alzheimer\u2019s disease pathology: A Tau perspective","author":"Sonawane","year":"2022"},{"issue":"23","key":"10.1016\/bs.apcsb.2024.08.004_bib56","doi-asserted-by":"crossref","first-page":"11183","DOI":"10.1073\/pnas.91.23.11183","article-title":"Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: Implications for Alzheimer disease","volume":"91","author":"Strittmatter","year":"1994","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"10","key":"10.1016\/bs.apcsb.2024.08.004_bib57","doi-asserted-by":"crossref","first-page":"7410","DOI":"10.1074\/jbc.275.10.7410","article-title":"Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer\u2019s disease","volume":"275","author":"Ulery","year":"2000","journal-title":"The Journal of Biological Chemistry"},{"issue":"10","key":"10.1016\/bs.apcsb.2024.08.004_bib58","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.neuron.2021.03.024","article-title":"Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia","volume":"109","author":"Wang","year":"2021","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/bs.apcsb.2024.08.004_bib59","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.tem.2023.05.002","article-title":"Apolipoprotein E in lipid metabolism and neurodegenerative disease","volume":"34","author":"Yang","year":"2023","journal-title":"Trends in Endocrinology and Metabolism: TEM"},{"key":"10.1016\/bs.apcsb.2024.08.004_bib60","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fnagi.2020.00150","article-title":"APOE alleles and diet in brain aging and Alzheimer\u2019s disease","volume":"12","author":"Yassine","year":"2020","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"38","key":"10.1016\/bs.apcsb.2024.08.004_bib61","doi-asserted-by":"crossref","first-page":"11965","DOI":"10.1073\/pnas.1510011112","article-title":"Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer\u2019s disease pathogenesis","volume":"112","author":"Zhu","year":"2015","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"9","key":"10.1016\/bs.apcsb.2024.08.004_bib62","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1093\/clinchem\/43.9.1657","article-title":"Improved method for genotyping apolipoprotein E polymorphisms by a PCR-based assay simultaneously utilizing two distinct restriction enzymes","volume":"43","author":"Zivelin","year":"1997","journal-title":"Clinical Chemistry"}],"container-title":["Advances in Protein Chemistry and Structural Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876162324000853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1876162324000853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T09:31:32Z","timestamp":1750757492000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1876162324000853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":62,"URL":"https:\/\/doi.org\/10.1016\/bs.apcsb.2024.08.004","relation":{},"ISSN":["1876-1623"],"issn-type":[{"value":"1876-1623","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}