{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T05:26:54Z","timestamp":1793165214427,"version":"4.5.0"},"reference-count":188,"publisher":"Elsevier","isbn-type":[{"value":"9780128031193","type":"print"}],"license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["8 P20 GM103549-07"],"award-info":[{"award-number":["8 P20 GM103549-07"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["5P20RR021940-07"],"award-info":[{"award-number":["5P20RR021940-07"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01DK098414"],"award-info":[{"award-number":["1R01DK098414"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01DK102487-01"],"award-info":[{"award-number":["1R01DK102487-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015]]},"DOI":"10.1016\/bs.apha.2015.04.003","type":"book-chapter","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T18:49:20Z","timestamp":1432838960000},"page":"263-302","source":"Crossref","is-referenced-by-count":293,"title":["Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer"],"prefix":"10.1016","author":[{"given":"Tiangang","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udayan","family":"Apte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.apha.2015.04.003_bb0005","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/1477-7819-12-164","article-title":"Secondary bile acids: An underrecognized cause of colon cancer","volume":"12","author":"Ajouz","year":"2014","journal-title":"World Journal of Surgical Oncology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0010","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1172\/JCI64551","article-title":"The TGR5 receptor mediates bile acid-induced itch and analgesia","volume":"123","author":"Alemi","year":"2013","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.apha.2015.04.003_bb0015","first-page":"5","article-title":"Recent advances in the development of farnesoid X receptor agonists","volume":"3","author":"Ali","year":"2015","journal-title":"Annals of Translational Medicine"},{"key":"10.1016\/bs.apha.2015.04.003_bb0020","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.ajpath.2010.11.026","article-title":"Bile acids induce inflammatory genes in hepatocytes: A novel mechanism of inflammation during obstructive cholestasis","volume":"178","author":"Allen","year":"2011","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0025","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1172\/JCI42846","article-title":"Combined deletion of Fxr and Shp in mice induces Cyp17a1 and results in juvenile onset cholestasis","volume":"121","author":"Anakk","year":"2011","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.apha.2015.04.003_bb0030","doi-asserted-by":"crossref","first-page":"28857","DOI":"10.1074\/jbc.M011610200","article-title":"Human bile salt export pump promoter is transactivated by the farnesoid X receptor\/bile acid receptor","volume":"276","author":"Ananthanarayanan","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0035","doi-asserted-by":"crossref","first-page":"8338","DOI":"10.1016\/S0021-9258(18)68482-0","article-title":"Identification of the hepatocyte Na+-dependent bile acid transport protein using monoclonal antibodies","volume":"263","author":"Ananthanarayanan","year":"1988","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1388-1981(99)00031-1","article-title":"6alpha-hydroxylation of taurochenodeoxycholic acid and lithocholic acid by CYP3A4 in human liver microsomes","volume":"1438","author":"Araya","year":"1999","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/bs.apha.2015.04.003_bb0045","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0022-2275(20)38509-6","article-title":"Occurrence of 3 beta-hydroxy-5-cholestenoic acid, 3 beta,7 alpha-dihydroxy-5-cholestenoic acid, and 7 alpha-hydroxy-3-oxo-4-cholestenoic acid as normal constituents in human blood","volume":"29","author":"Axelson","year":"1988","journal-title":"The Journal of Lipid Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0050","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/hep.24537","article-title":"Dual farnesoid X receptor\/TGR5 agonist INT-767 reduces liver injury in the Mdr2-\/- (Abcb4-\/-) mouse cholangiopathy model by promoting biliary HCO(-)(3) output","volume":"54","author":"Baghdasaryan","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0055","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1002\/hep.20961","article-title":"OSTalpha-OSTbeta: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia","volume":"42","author":"Ballatori","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0060","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1016\/S0016-5085(03)00388-3","article-title":"FXR induces the UGT2B4 enzyme in hepatocytes: A potential mechanism of negative feedback control of FXR activity","volume":"124","author":"Barbier","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0065","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1124\/dmd.108.023317","article-title":"Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice","volume":"37","author":"Beilke","year":"2009","journal-title":"Drug Metabolism and Disposition"},{"key":"10.1016\/bs.apha.2015.04.003_bb0070","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.tem.2003.10.005","article-title":"Inactivation of androgens by UDP-glucuronosyltransferase enzymes in humans","volume":"14","author":"Belanger","year":"2003","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/bs.apha.2015.04.003_bb0075","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1126\/science.290.5497.1771","article-title":"Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters","volume":"290","author":"Berge","year":"2000","journal-title":"Science"},{"key":"10.1016\/bs.apha.2015.04.003_bb0080","doi-asserted-by":"crossref","first-page":"45139","DOI":"10.1074\/jbc.M405423200","article-title":"Ligand-activated PXR interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha: Functional implications in hepatic cholesterol and glucose metabolism","volume":"279","author":"Bhalla","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0085","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1073\/pnas.0400046101","article-title":"Expression and activation of the farnesoid X receptor in the vasculature","volume":"101","author":"Bishop-Bailey","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.apha.2015.04.003_bb0090","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0022-2275(20)38290-0","article-title":"Mechanism of intestinal formation of deoxycholic acid from cholic acid in humans: Evidence for a 3-oxo-delta 4-steroid intermediate","volume":"30","author":"Bjorkhem","year":"1989","journal-title":"The Journal of Lipid Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0095","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbalip.2004.11.003","article-title":"Novel pathways of bile acid metabolism involving CYP3A4","volume":"1687","author":"Bodin","year":"2005","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/bs.apha.2015.04.003_bb0100","doi-asserted-by":"crossref","first-page":"2344","DOI":"10.1002\/hep.25918","article-title":"Hepatocyte-specific deletion of farnesoid X receptor delays but does not inhibit liver regeneration after partial hepatectomy in mice","volume":"56","author":"Borude","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0105","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1002\/j.2040-4603.2013.tb00519.x","article-title":"Bile formation and secretion","volume":"3","author":"Boyer","year":"2013","journal-title":"Comprehensive Physiology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0110","doi-asserted-by":"crossref","first-page":"G1124","DOI":"10.1152\/ajpgi.00539.2005","article-title":"Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents","volume":"290","author":"Boyer","year":"2006","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0115","first-page":"81","article-title":"Serum unconjugated primary and secondary bile acids in patients with cholangiocarcinoma and hepatocellular carcinoma","volume":"73","author":"Changbumrung","year":"1990","journal-title":"Journal of the Medical Association of Thailand=Chotmaihet thangphaet"},{"key":"10.1016\/bs.apha.2015.04.003_bb0120","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0076-6879(05)00010-8","article-title":"Vitamin D receptor regulation of the steroid\/bile acid sulfotransferase SULT2A1","volume":"400","author":"Chatterjee","year":"2005","journal-title":"Methods in Enzymology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0125","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1124\/mol.105.020792","article-title":"Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor","volume":"69","author":"Chen","year":"2006","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0130","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0378-1119(03)00631-0","article-title":"Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha)","volume":"313","author":"Chen","year":"2003","journal-title":"Gene"},{"key":"10.1016\/bs.apha.2015.04.003_bb0135","doi-asserted-by":"crossref","first-page":"19909","DOI":"10.1074\/jbc.M207903200","article-title":"Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter","volume":"278","author":"Chen","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0140","first-page":"7","article-title":"The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis","volume":"2","author":"Chen","year":"2014","journal-title":"Annals of Translational Medicine"},{"key":"10.1016\/bs.apha.2015.04.003_bb0145","doi-asserted-by":"crossref","first-page":"G349","DOI":"10.1152\/ajpgi.00417.2002","article-title":"Bile acid regulation of hepatic physiology: III. Bile acids and nuclear receptors","volume":"284","author":"Chiang","year":"2003","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0150","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1194\/jlr.R900010-JLR200","article-title":"Bile acids: Regulation of synthesis","volume":"50","author":"Chiang","year":"2009","journal-title":"The Journal of Lipid Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0155","first-page":"2029","article-title":"Identification of a sister gene to P-glycoprotein","volume":"55","author":"Childs","year":"1995","journal-title":"Cancer Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0160","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1053\/j.gastro.2013.12.027","article-title":"Vitamin D receptor activation down-regulates small heterodimer partner and increases CYP7A1 to lower cholesterol","volume":"146","author":"Chow","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0165","doi-asserted-by":"crossref","first-page":"e25637","DOI":"10.1371\/journal.pone.0025637","article-title":"The bile acid receptor GPBAR-1 (TGR5) modulates integrity of intestinal barrier and immune response to experimental colitis","volume":"6","author":"Cipriani","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/bs.apha.2015.04.003_bb0170","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/toxsci\/kfp094","article-title":"Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice","volume":"110","author":"Cui","year":"2009","journal-title":"Toxicological Sciences: An Official Journal of the Society of Toxicology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0175","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1053\/gast.2001.25503","article-title":"The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp","volume":"121","author":"Denson","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0180","doi-asserted-by":"crossref","first-page":"25125","DOI":"10.1074\/jbc.M201323200","article-title":"Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes","volume":"277","author":"Drocourt","year":"2002","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0185","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/nrgastro.2015.12","article-title":"Novel therapeutic targets in primary biliary cirrhosis","volume":"12","author":"Dyson","year":"2015","journal-title":"Nature Reviews. Gastroenterology & Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0190","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1053\/j.gastro.2013.06.052","article-title":"Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management","volume":"145","author":"Eaton","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0195","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1042\/cs1000499","article-title":"Increased levels of typically fetal bile acid species in patients with hepatocellular carcinoma","volume":"100","author":"El-Mir","year":"2001","journal-title":"Clinical Science"},{"key":"10.1016\/bs.apha.2015.04.003_bb0200","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1194\/jlr.M200489-JLR200","article-title":"Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice","volume":"44","author":"Erickson","year":"2003","journal-title":"The Journal of Lipid Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0205","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bbagrm.2014.05.021","article-title":"Bile acid signaling and liver regeneration","volume":"1849","author":"Fan","year":"2015","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/bs.apha.2015.04.003_bb0210","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1124\/jpet.104.079665","article-title":"Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis","volume":"313","author":"Fiorucci","year":"2005","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/bs.apha.2015.04.003_bb0215","doi-asserted-by":"crossref","first-page":"G912","DOI":"10.1152\/ajpgi.00479.2005","article-title":"Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids","volume":"290","author":"Frankenberg","year":"2006","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0220","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0009-2797(00)00197-6","article-title":"Epoxide hydrolases: Biochemistry and molecular biology","volume":"129","author":"Fretland","year":"2000","journal-title":"Chemico-Biological Interactions"},{"key":"10.1016\/bs.apha.2015.04.003_bb0225","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/gut.2010.212159","article-title":"Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease","volume":"60","author":"Gadaleta","year":"2011","journal-title":"Gut"},{"key":"10.1016\/bs.apha.2015.04.003_bb0230","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0960-0760(99)00088-6","article-title":"Differential glucuronidation of bile acids, androgens and estrogens by human UGT1A3 and 2B7","volume":"70","author":"Gall","year":"1999","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0235","doi-asserted-by":"crossref","first-page":"3417","DOI":"10.1128\/MCB.02249-06","article-title":"Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members","volume":"27","author":"Goetz","year":"2007","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0240","doi-asserted-by":"crossref","first-page":"4741","DOI":"10.1073\/pnas.91.11.4741","article-title":"Molecular cloning, tissue distribution, and expression of a 14-kDa bile acid-binding protein from rat ileal cytosol","volume":"91","author":"Gong","year":"1994","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.apha.2015.04.003_bb0245","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S1097-2765(00)00051-4","article-title":"A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis","volume":"6","author":"Goodwin","year":"2000","journal-title":"Molecular Cell"},{"key":"10.1016\/bs.apha.2015.04.003_bb0250","doi-asserted-by":"crossref","first-page":"45062","DOI":"10.1074\/jbc.M307145200","article-title":"Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity","volume":"278","author":"Guo","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0255","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1172\/JCI117091","article-title":"Molecular cloning, chromosomal localization, and functional characterization of a human liver Na+\/bile acid cotransporter","volume":"93","author":"Hagenbuch","year":"1994","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.apha.2015.04.003_bb0260","doi-asserted-by":"crossref","first-page":"10629","DOI":"10.1073\/pnas.88.23.10629","article-title":"Functional expression cloning and characterization of the hepatocyte Na+\/bile acid cotransport system","volume":"88","author":"Hagenbuch","year":"1991","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.apha.2015.04.003_bb0265","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1002\/hep.22891","article-title":"Side chain structure determines unique physiologic and therapeutic properties of norursodeoxycholic acid in Mdr2-\/- mice","volume":"49","author":"Halilbasic","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0270","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1210\/me.2009-0482","article-title":"A novel bile acid-activated vitamin D receptor signaling in human hepatocytes","volume":"24","author":"Han","year":"2010","journal-title":"Molecular Endocrinology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0275","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.1194\/jlr.M500390-JLR200","article-title":"Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice","volume":"46","author":"Hanniman","year":"2005","journal-title":"The Journal of Lipid Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0280","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0009-8981(76)90270-9","article-title":"Serum cholesterol and bile acid in primary hepatoma","volume":"71","author":"Hirayama","year":"1976","journal-title":"Clinica Chimica Acta; International Journal of Clinical Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0285","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1053\/j.gastro.2014.12.005","article-title":"Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid","volume":"148","author":"Hirschfield","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0290","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1042\/CS20040339","article-title":"Genetic variation in the rate-limiting enzyme in cholesterol catabolism (cholesterol 7alpha-hydroxylase) influences the progression of atherosclerosis and risk of new clinical events","volume":"108","author":"Hofman","year":"2005","journal-title":"Clinical Science"},{"key":"10.1016\/bs.apha.2015.04.003_bb0295","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1136\/gut.51.5.756","article-title":"Rifampicin and treatment of cholestatic pruritus","volume":"51","author":"Hofmann","year":"2002","journal-title":"Gut"},{"key":"10.1016\/bs.apha.2015.04.003_bb0300","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1126\/science.1121435","article-title":"Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration","volume":"312","author":"Huang","year":"2006","journal-title":"Science"},{"key":"10.1016\/bs.apha.2015.04.003_bb0305","first-page":"1735","article-title":"Deoxycholic acid influences cholesterol solubilization and microcrystal nucleation time in gallbladder bile","volume":"22","author":"Hussaini","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0310","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0022-2275(20)42247-3","article-title":"Mechanism of intestinal 7 alpha-dehydroxylation of cholic acid: Evidence that allo-deoxycholic acid is an inducible side-product","volume":"32","author":"Hylemon","year":"1991","journal-title":"The Journal of Lipid Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0315","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2005.09.001","article-title":"Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis","volume":"2","author":"Inagaki","year":"2005","journal-title":"Cell Metabolism"},{"key":"10.1016\/bs.apha.2015.04.003_bb0320","doi-asserted-by":"crossref","first-page":"18017","DOI":"10.1074\/jbc.271.30.18017","article-title":"Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation","volume":"271","author":"Ishibashi","year":"1996","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0325","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1172\/JCI23076","article-title":"Impaired negative feedback suppression of bile acid synthesis in mice lacking betaKlotho","volume":"115","author":"Ito","year":"2005","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.apha.2015.04.003_bb0330","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.3748\/wjg.v10.i10.1508","article-title":"Polymorphisms at cholesterol 7alpha-hydroxylase, apolipoproteins B and E and low density lipoprotein receptor genes in patients with gallbladder stone disease","volume":"10","author":"Jiang","year":"2004","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0335","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.atherosclerosis.2004.03.015","article-title":"Interactions between common genetic polymorphisms in ABCG5\/G8 and CYP7A1 on LDL cholesterol-lowering response to atorvastatin","volume":"175","author":"Kajinami","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/bs.apha.2015.04.003_bb0340","doi-asserted-by":"crossref","first-page":"2908","DOI":"10.1074\/jbc.M109326200","article-title":"Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor","volume":"277","author":"Kast","year":"2002","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0345","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1158\/1541-7786.MCR-07-0172","article-title":"Molecular mechanisms of liver carcinogenesis in the mdr2-knockout mice","volume":"5","author":"Katzenellenbogen","year":"2007","journal-title":"Molecular Cancer Research: MCR"},{"key":"10.1016\/bs.apha.2015.04.003_bb0350","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1158\/0008-5472.CAN-05-2937","article-title":"Multiple adaptive mechanisms to chronic liver disease revealed at early stages of liver carcinogenesis in the Mdr2-knockout mice","volume":"66","author":"Katzenellenbogen","year":"2006","journal-title":"Cancer Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0355","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1081\/DMR-200033496","article-title":"Sulfonation in pharmacology and toxicology","volume":"36","author":"Kauffman","year":"2004","journal-title":"Drug Metabolism Reviews"},{"key":"10.1016\/bs.apha.2015.04.003_bb0360","doi-asserted-by":"crossref","first-page":"9435","DOI":"10.1074\/jbc.M209706200","article-title":"A G protein-coupled receptor responsive to bile acids","volume":"278","author":"Kawamata","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0365","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.bbrc.2008.04.171","article-title":"Expression and function of the bile acid receptor TGR5 in Kupffer cells","volume":"372","author":"Keitel","year":"2008","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/bs.apha.2015.04.003_bb0370","doi-asserted-by":"crossref","first-page":"G165","DOI":"10.1152\/ajpgi.00362.2002","article-title":"A common Dubin-Johnson syndrome mutation impairs protein maturation and transport activity of MRP2 (ABCC2)","volume":"284","author":"Keitel","year":"2003","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0375","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/hep.21458","article-title":"The G-protein coupled bile salt receptor TGR5 is expressed in liver sinusoidal endothelial cells","volume":"45","author":"Keitel","year":"2007","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0380","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1093\/carcin\/bgl249","article-title":"Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice","volume":"28","author":"Kim","year":"2007","journal-title":"Carcinogenesis"},{"key":"10.1016\/bs.apha.2015.04.003_bb0385","doi-asserted-by":"crossref","first-page":"17838","DOI":"10.1074\/jbc.M210634200","article-title":"Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity","volume":"278","author":"Kitada","year":"2003","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0390","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1210\/er.2001-0038","article-title":"The nuclear pregnane X receptor: A key regulator of xenobiotic metabolism","volume":"23","author":"Kliewer","year":"2002","journal-title":"Endocrine Reviews"},{"key":"10.1016\/bs.apha.2015.04.003_bb0395","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0022-2275(20)30141-3","article-title":"Regulation of xenobiotic and bile acid metabolism by the nuclear pregnane X receptor","volume":"43","author":"Kliewer","year":"2002","journal-title":"The Journal of Lipid Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0400","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1055\/s-2000-9426","article-title":"Hepatic transport of bile salts","volume":"20","author":"Kullak-Ublick","year":"2000","journal-title":"Seminars in Liver Disease"},{"key":"10.1016\/bs.apha.2015.04.003_bb0405","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/01.fpc.0000230418.28091.76","article-title":"Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury","volume":"17","author":"Lang","year":"2007","journal-title":"Pharmacogenetics and Genomics"},{"key":"10.1016\/bs.apha.2015.04.003_bb0410","first-page":"907","article-title":"Cerebrotendinous xanthomatosis in the Israeli Druze: Molecular genetics and phenotypic characteristics","volume":"55","author":"Leitersdorf","year":"1994","journal-title":"The American Journal of Human Genetics"},{"key":"10.1016\/bs.apha.2015.04.003_bb0415","doi-asserted-by":"crossref","first-page":"G74","DOI":"10.1152\/ajpgi.00258.2004","article-title":"Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription","volume":"288","author":"Li","year":"2005","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0420","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1124\/pr.113.008201","article-title":"Bile acid signaling in metabolic disease and drug therapy","volume":"66","author":"Li","year":"2014","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/bs.apha.2015.04.003_bb0425","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1074\/jbc.M111.305789","article-title":"Glucose and insulin induction of bile acid synthesis: Mechanisms and implication in diabetes and obesity","volume":"287","author":"Li","year":"2012","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0430","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cmet.2014.05.020","article-title":"Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15\/19 signaling to repress bile acid synthesis","volume":"20","author":"Li","year":"2014","journal-title":"Cell Metabolism"},{"key":"10.1016\/bs.apha.2015.04.003_bb0435","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/hep.24107","article-title":"Overexpression of cholesterol 7alpha-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis","volume":"53","author":"Li","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0440","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/hep.23721","article-title":"Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice","volume":"52","author":"Li","year":"2010","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0445","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1172\/JCI0216309","article-title":"Cholic acid mediates negative feedback regulation of bile acid synthesis in mice","volume":"110","author":"Li-Hawkins","year":"2002","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.apha.2015.04.003_bb0450","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1002\/hep.22221","article-title":"Mechanisms of hepatocyte growth factor-mediated and epidermal growth factor-mediated signaling in transdifferentiation of rat hepatocytes to biliary epithelium","volume":"47","author":"Limaye","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0455","doi-asserted-by":"crossref","first-page":"27277","DOI":"10.1074\/jbc.M704244200","article-title":"Liver-specific activities of FGF19 require Klotho beta","volume":"282","author":"Lin","year":"2007","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0460","doi-asserted-by":"crossref","first-page":"3622","DOI":"10.2174\/138161211798220909","article-title":"Lipid lowering drugs and gallstones: A therapeutic option?","volume":"17","author":"Lioudaki","year":"2011","journal-title":"Current Pharmaceutical Design"},{"key":"10.1016\/bs.apha.2015.04.003_bb0465","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1172\/JCI18945","article-title":"Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis","volume":"112","author":"Liu","year":"2003","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.apha.2015.04.003_bb0470","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1002\/hep.27085","article-title":"Conjugated bile acids promote cholangiocarcinoma cell invasive growth through activation of sphingosine 1-phosphate receptor 2","volume":"60","author":"Liu","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0475","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0140-6736(78)91800-7","article-title":"Colonic bacterial activity, biliary cholesterol saturation, and pathogenesis of gallstones","volume":"2","author":"Low-Beer","year":"1978","journal-title":"Lancet"},{"key":"10.1016\/bs.apha.2015.04.003_bb0480","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1124\/dmd.104.003061","article-title":"Lithocholic acid decreases expression of UGT2B7 in Caco-2 cells: A potential role for a negative farnesoid X receptor response element","volume":"33","author":"Lu","year":"2005","journal-title":"Drug Metabolism and Disposition"},{"key":"10.1016\/bs.apha.2015.04.003_bb0485","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S1097-2765(00)00050-2","article-title":"Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors","volume":"6","author":"Lu","year":"2000","journal-title":"Molecular Cell"},{"key":"10.1016\/bs.apha.2015.04.003_bb0490","first-page":"323","article-title":"Bile acid biosynthesis during liver regeneration: Enzyme activities of cholesterol 7alpha-hydroxylase and 3beta-hydroxy-delta5-C27-steroid dehydrogenase in rats","volume":"35","author":"Maeda","year":"2005","journal-title":"Annals of Clinical and Laboratory Science"},{"key":"10.1016\/bs.apha.2015.04.003_bb0495","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.1070477","article-title":"Vitamin D receptor as an intestinal bile acid sensor","volume":"296","author":"Makishima","year":"2002","journal-title":"Science"},{"key":"10.1016\/bs.apha.2015.04.003_bb0500","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1126\/science.284.5418.1362","article-title":"Identification of a nuclear receptor for bile acids","volume":"284","author":"Makishima","year":"1999","journal-title":"Science"},{"key":"10.1016\/bs.apha.2015.04.003_bb0505","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/0092-8674(95)90200-7","article-title":"The RXR heterodimers and orphan receptors","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"10.1016\/bs.apha.2015.04.003_bb0510","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(95)90199-X","article-title":"The nuclear receptor superfamily: The second decade","volume":"83","author":"Mangelsdorf","year":"1995","journal-title":"Cell"},{"key":"10.1016\/bs.apha.2015.04.003_bb0515","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1136\/gut.29.4.522","article-title":"Deoxycholic acid and the pathogenesis of gall stones","volume":"29","author":"Marcus","year":"1988","journal-title":"Gut"},{"key":"10.1016\/bs.apha.2015.04.003_bb0520","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0006-291X(02)02550-0","article-title":"Identification of membrane-type receptor for bile acids (M-BAR)","volume":"298","author":"Maruyama","year":"2002","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/bs.apha.2015.04.003_bb0525","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1677\/joe.1.06546","article-title":"Targeted disruption of G protein-coupled bile acid receptor 1 (Gpbar1\/M-Bar) in mice","volume":"191","author":"Maruyama","year":"2006","journal-title":"The Journal of Endocrinology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0530","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0039-128X(78)80048-8","article-title":"The suppressive effect of the catatoxic steroid, pregnenolone-16alpha-carbonitrile, on liver microsomal cholesterol-7alpha-hydroxlyase","volume":"31","author":"Mason","year":"1978","journal-title":"Steroids"},{"key":"10.1016\/bs.apha.2015.04.003_bb0535","doi-asserted-by":"crossref","first-page":"23232","DOI":"10.1074\/jbc.M411520200","article-title":"Vitamin D receptor-dependent regulation of colon multidrug resistance-associated protein 3 gene expression by bile acids","volume":"280","author":"McCarthy","year":"2005","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0540","doi-asserted-by":"crossref","first-page":"11761","DOI":"10.1074\/jbc.M112.446575","article-title":"Bile acid receptor activation modulates hepatic monocyte activity and improves nonalcoholic fatty liver disease","volume":"288","author":"McMahan","year":"2013","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0545","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/01926230590881808","article-title":"Tissue repair: An important determinant of final outcome of toxicant-induced injury","volume":"33","author":"Mehendale","year":"2005","journal-title":"Toxicologic Pathology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0550","first-page":"G801","article-title":"Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile","volume":"269","author":"Meier","year":"1995","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0555","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev.physiol.64.082201.100300","article-title":"Bile salt transporters","volume":"64","author":"Meier","year":"2002","journal-title":"Annual Review of Physiology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0560","doi-asserted-by":"crossref","first-page":"H272","DOI":"10.1152\/ajpheart.01075.2008","article-title":"Antiatherosclerotic effect of farnesoid X receptor","volume":"296","author":"Mencarelli","year":"2009","journal-title":"American Journal of Physiology. Heart and Circulatory Physiology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0565","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1210\/me.2009-0286","article-title":"FXR regulates liver repair after CCl4-induced toxic injury","volume":"24","author":"Meng","year":"2010","journal-title":"Molecular Endocrinology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0570","doi-asserted-by":"crossref","first-page":"14537","DOI":"10.1074\/jbc.M510713200","article-title":"Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid\/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha","volume":"281","author":"Miao","year":"2006","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0575","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/j.2040-4603.2013.tb00493.x","article-title":"Principles of liver regeneration and growth homeostasis","volume":"3","author":"Michalopoulos","year":"2013","journal-title":"Comprehensive Physiology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0580","doi-asserted-by":"crossref","first-page":"23304","DOI":"10.1074\/jbc.M101853200","article-title":"Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7alpha-hydroxylase","volume":"276","author":"Miyake","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0585","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1161\/hq0102.102588","article-title":"Transgenic expression of cholesterol-7-alpha-hydroxylase prevents atherosclerosis in C57BL\/6J mice","volume":"22","author":"Miyake","year":"2002","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0590","doi-asserted-by":"crossref","first-page":"23963","DOI":"10.1074\/jbc.274.34.23963","article-title":"Targeted disruption of the microsomal epoxide hydrolase gene. Microsomal epoxide hydrolase is required for the carcinogenic activity of 7,12-dimethylbenz[a]anthracene","volume":"274","author":"Miyata","year":"1999","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0595","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0022-2275(20)41693-1","article-title":"Cholesterol 7 alpha-hydroxylase","volume":"18","author":"Myant","year":"1977","journal-title":"The Journal of Lipid Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0600","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1210\/er.2004-0002","article-title":"Noncalcemic actions of vitamin D receptor ligands","volume":"26","author":"Nagpal","year":"2005","journal-title":"Endocrine Reviews"},{"key":"10.1016\/bs.apha.2015.04.003_bb0605","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1159\/000129425","article-title":"Hepatic cholesterol 7 alpha-hydroxylase activity and serum 7 alpha-hydroxy-cholesterol level during liver regeneration after partial hepatectomy in rats","volume":"27","author":"Nakano","year":"1995","journal-title":"European Surgical Research Europaische Chirurgische Forschung Recherches Chirurgicales Europeennes"},{"key":"10.1016\/bs.apha.2015.04.003_bb0610","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/hep.20295","article-title":"Bile acid-induced negative feedback regulation of the human ileal bile acid transporter","volume":"40","author":"Neimark","year":"2004","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0615","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S0140-6736(14)61933-4","article-title":"Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): A multicentre, randomised, placebo-controlled trial","volume":"385","author":"Neuschwander-Tetri","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/bs.apha.2015.04.003_bb0620","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1124\/dmd.109.027334","article-title":"Modulation of bile acid metabolism by 1alpha-hydroxyvitamin D3 administration in mice","volume":"37","author":"Nishida","year":"2009","journal-title":"Drug Metabolism and Disposition"},{"key":"10.1016\/bs.apha.2015.04.003_bb0625","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.jhep.2005.05.020","article-title":"Impaired expression and function of the bile salt export pump due to three novel ABCB11 mutations in intrahepatic cholestasis","volume":"43","author":"Noe","year":"2005","journal-title":"Journal of Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0630","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1124\/jpet.108.145987","article-title":"Vitamin D3 modulates the expression of bile acid regulatory genes and represses inflammation in bile duct-ligated mice","volume":"328","author":"Ogura","year":"2009","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"issue":"Suppl.","key":"10.1016\/bs.apha.2015.04.003_bb0635","doi-asserted-by":"crossref","first-page":"D71","DOI":"10.1046\/j.1440-1746.2000.02178.x","article-title":"Pathophysiological role of cholecystokinin in humans","volume":"15","author":"Otsuki","year":"2000","journal-title":"Journal of Gastroenterology and Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0640","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1126\/science.284.5418.1365","article-title":"Bile acids: Natural ligands for an orphan nuclear receptor","volume":"284","author":"Parks","year":"1999","journal-title":"Science"},{"key":"10.1016\/bs.apha.2015.04.003_bb0645","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/00008571-200402000-00003","article-title":"Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy","volume":"14","author":"Pauli-Magnus","year":"2004","journal-title":"Pharmacogenetics"},{"key":"10.1016\/bs.apha.2015.04.003_bb0650","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1002\/hep.26463","article-title":"The receptor TGR5 protects the liver from bile acid overload during liver regeneration in mice","volume":"58","author":"Pean","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0655","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1021\/jm049904b","article-title":"Bile acid derivatives as ligands of the farnesoid X receptor. Synthesis, evaluation, and structure-activity relationship of a series of body and side chain modified analogues of chenodeoxycholic acid","volume":"47","author":"Pellicciari","year":"2004","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0660","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1021\/jm025529g","article-title":"6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity","volume":"45","author":"Pellicciari","year":"2002","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0665","doi-asserted-by":"crossref","first-page":"25636","DOI":"10.1016\/S0021-9258(19)74437-8","article-title":"Glucuronidation of hyodeoxycholic acid in human liver. Evidence for a selective role of UDP-glucuronosyltransferase 2B4","volume":"268","author":"Pillot","year":"1993","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0670","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1172\/JCI0215387","article-title":"Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype","volume":"110","author":"Pullinger","year":"2002","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.apha.2015.04.003_bb0675","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1073\/pnas.0712328105","article-title":"The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis","volume":"105","author":"Rao","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.apha.2015.04.003_bb0680","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4161\/cbt.5.3.2728","article-title":"A potential role for resistant starch fermentation in modulating colonic bacterial metabolism and colon cancer risk","volume":"5","author":"Ridlon","year":"2006","journal-title":"Cancer Biology & Therapy"},{"key":"10.1016\/bs.apha.2015.04.003_bb0685","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","article-title":"Bile salt biotransformations by human intestinal bacteria","volume":"47","author":"Ridlon","year":"2006","journal-title":"The Journal of Lipid Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0690","doi-asserted-by":"crossref","first-page":"14805","DOI":"10.1074\/jbc.273.24.14805","article-title":"Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene","volume":"273","author":"Rosen","year":"1998","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0695","doi-asserted-by":"crossref","first-page":"1370174","DOI":"10.1146\/annurev.biochem.72.121801.161712","article-title":"The enzymes, regulation, and genetics of bile acid synthesis","volume":"72","author":"Russell","year":"2003","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0700","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1021\/bi00135a001","article-title":"Bile acid biosynthesis","volume":"31","author":"Russell","year":"1992","journal-title":"Biochemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0705","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1124\/mol.65.2.292","article-title":"A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification","volume":"65","author":"Saini","year":"2004","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0710","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.cmet.2013.01.003","article-title":"Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist","volume":"17","author":"Sayin","year":"2013","journal-title":"Cell Metabolism"},{"key":"10.1016\/bs.apha.2015.04.003_bb0715","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1002\/hep.22771","article-title":"High expression of the bile salt-homeostatic hormone fibroblast growth factor 19 in the liver of patients with extrahepatic cholestasis","volume":"49","author":"Schaap","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0720","doi-asserted-by":"crossref","first-page":"14486","DOI":"10.1074\/jbc.M110.116004","article-title":"Regulation of bile acid synthesis by fat-soluble vitamins A and D","volume":"285","author":"Schmidt","year":"2010","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0725","first-page":"1446","article-title":"Induction of CYP3A4 by 1 alpha,25-dihydroxyvitamin D3 is human cell line-specific and is unlikely to involve pregnane X receptor","volume":"29","author":"Schmiedlin-Ren","year":"2001","journal-title":"Drug Metabolism and Disposition"},{"key":"10.1016\/bs.apha.2015.04.003_bb0730","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1172\/JCI117722","article-title":"Cloning and molecular characterization of the ontogeny of a rat ileal sodium-dependent bile acid transporter","volume":"95","author":"Shneider","year":"1995","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.apha.2015.04.003_bb0735","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1194\/jlr.M009308","article-title":"Abolished synthesis of cholic acid reduces atherosclerotic development in apolipoprotein E knockout mice","volume":"51","author":"Slatis","year":"2010","journal-title":"The Journal of Lipid Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0740","doi-asserted-by":"crossref","DOI":"10.1002\/hep.27694","article-title":"Impaired uptake of conjugated bile acids and Hepatitis B Virus preS1-binding in Na -taurocholate cotransporting polypeptide knockout mice","author":"Slijepcevic","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0745","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/0092-8674(93)90380-9","article-title":"Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease","volume":"75","author":"Smit","year":"1993","journal-title":"Cell"},{"key":"10.1016\/bs.apha.2015.04.003_bb0750","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hep.22627","article-title":"Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression","volume":"49","author":"Song","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0755","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jceh.2013.10.005","article-title":"Progressive familial intrahepatic cholestasis","volume":"4","author":"Srivastava","year":"2014","journal-title":"Journal of Clinical and Experimental Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0760","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/BF02536046","article-title":"Effects of pregnenolone-16 alpha-carbonitrile on the metabolism of cholesterol in rat liver microsomes","volume":"30","author":"Stahlberg","year":"1995","journal-title":"Lipids"},{"key":"10.1016\/bs.apha.2015.04.003_bb0765","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/03602530600786232","article-title":"PXR and CAR: Nuclear receptors which play a pivotal role in drug disposition and chemical toxicity","volume":"38","author":"Stanley","year":"2006","journal-title":"Drug Metabolism Reviews"},{"key":"10.1016\/bs.apha.2015.04.003_bb0770","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1073\/pnas.051551698","article-title":"The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity","volume":"98","author":"Staudinger","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.apha.2015.04.003_bb0775","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1073\/pnas.0409794102","article-title":"Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury","volume":"102","author":"Stedman","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.apha.2015.04.003_bb0780","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1086\/515501","article-title":"Identification of a locus for progressive familial intrahepatic cholestasis PFIC2 on chromosome 2q24","volume":"61","author":"Strautnieks","year":"1997","journal-title":"The American Journal of Human Genetics"},{"key":"10.1016\/bs.apha.2015.04.003_bb0785","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1002\/hep.24681","article-title":"Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes","volume":"55","author":"Studer","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0790","first-page":"189","article-title":"Serum concentrations of bile acid glucuronides in hepatobiliary diseases","volume":"27","author":"Takikawa","year":"1983","journal-title":"Digestion"},{"key":"10.1016\/bs.apha.2015.04.003_bb0795","doi-asserted-by":"crossref","first-page":"21030","DOI":"10.1016\/S0021-9258(18)54816-X","article-title":"Cloning, expression, and regulation of lithocholic acid 6 beta-hydroxylase","volume":"266","author":"Teixeira","year":"1991","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0800","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1124\/mol.60.6.1399","article-title":"Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3","volume":"60","author":"Thummel","year":"2001","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0805","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2169\/internalmedicine.52.0010","article-title":"Risk factors for survival and the development of hepatocellular carcinoma in patients with primary biliary cirrhosis","volume":"52","author":"Tomiyama","year":"2013","journal-title":"Internal Medicine"},{"key":"10.1016\/bs.apha.2015.04.003_bb0810","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1152\/physrev.00027.2002","article-title":"Bile salt transporters: Molecular characterization, function, and regulation","volume":"83","author":"Trauner","year":"2003","journal-title":"Physiological Reviews"},{"key":"10.1016\/bs.apha.2015.04.003_bb0815","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1002\/hep.21362","article-title":"Human UDP-glucuronosyltransferase (UGT)1A3 enzyme conjugates chenodeoxycholic acid in the liver","volume":"44","author":"Trottier","year":"2006","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0820","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/gutjnl-2012-302945","article-title":"Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice","volume":"62","author":"Uriarte","year":"2013","journal-title":"Gut"},{"key":"10.1016\/bs.apha.2015.04.003_bb0825","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.mce.2012.06.025","article-title":"Nuclear receptors in regenerating liver and hepatocellular carcinoma","volume":"368","author":"Vacca","year":"2013","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0830","doi-asserted-by":"crossref","first-page":"6251","DOI":"10.4049\/jimmunol.0803978","article-title":"The bile acid receptor FXR is a modulator of intestinal innate immunity","volume":"183","author":"Vavassori","year":"2009","journal-title":"Journal of Immunology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0835","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/hep.27240","article-title":"Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype","volume":"61","author":"Vaz","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0840","first-page":"G528","article-title":"Na(+)-dependent bile acid transport by hepatocytes is mediated by a protein similar to microsomal epoxide hydrolase","volume":"264","author":"Von Dippe","year":"1993","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0845","doi-asserted-by":"crossref","first-page":"18176","DOI":"10.1074\/jbc.271.30.18176","article-title":"The functional expression of sodium-dependent bile acid transport in Madin-Darby canine kidney cells transfected with the cDNA for microsomal epoxide hydrolase","volume":"271","author":"von Dippe","year":"1996","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0850","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/hep.22519","article-title":"Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response","volume":"48","author":"Wang","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0855","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1002\/hep.24525","article-title":"The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-kappaB) in mice","volume":"54","author":"Wang","year":"2011","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0860","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1172\/JCI41514","article-title":"Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice","volume":"121","author":"Wang","year":"2011","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.apha.2015.04.003_bb0865","doi-asserted-by":"crossref","first-page":"703","DOI":"10.2174\/1566524014666140724095112","article-title":"Hepatocyte FRS2alpha is essential for the endocrine fibroblast growth factor to limit the amplitude of bile acid production induced by prandial activity","volume":"14","author":"Wang","year":"2014","journal-title":"Current Molecular Medicine"},{"key":"10.1016\/bs.apha.2015.04.003_bb0870","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1096\/fasebj.11.1.9034160","article-title":"Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes","volume":"11","author":"Weinshilboum","year":"1997","journal-title":"The FASEB Journal"},{"key":"10.1016\/bs.apha.2015.04.003_bb0875","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.3748\/wjg.v13.i31.4230","article-title":"Lithocholic acid induction of the FGF19 promoter in intestinal cells is mediated by PXR","volume":"13","author":"Wistuba","year":"2007","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0880","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.3748\/wjg.v12.i22.3553","article-title":"Bile acid interactions with cholangiocytes","volume":"12","author":"Xia","year":"2006","journal-title":"World Journal of Gastroenterology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0885","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1158\/0008-5472.CAN-06-1078","article-title":"Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor","volume":"67","author":"Yang","year":"2007","journal-title":"Cancer Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0890","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/hep.510260218","article-title":"Effect of side chain length on biotransformation, hepatic transport, and choleretic properties of chenodeoxycholyl homologues in the rodent: Studies with dinorchenodeoxycholic acid, norchenodeoxycholic acid, and chenodeoxycholic acid","volume":"26","author":"Yeh","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0895","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00534-006-1125-1","article-title":"Mechanism of impaired hepatic regeneration in cholestatic liver","volume":"14","author":"Yokoyama","year":"2007","journal-title":"Journal of Hepato-Biliary-Pancreatic Surgery"},{"key":"10.1016\/bs.apha.2015.04.003_bb0900","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/imm.12045","article-title":"TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease","volume":"139","author":"Yoneno","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0905","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0016-5085(86)90859-0","article-title":"Effect of side-chain shortening on the physiologic properties of bile acids: Hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents","volume":"90","author":"Yoon","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0910","doi-asserted-by":"crossref","first-page":"41690","DOI":"10.1074\/jbc.M105117200","article-title":"Transcriptional regulation of the human sterol 12a-hydroxylase gene (CYP8B1): Roles of hepatocyte nuclear factor 4a (HNF4a) in mediating bile acid repression","volume":"276","author":"Zhang","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2015.04.003_bb0915","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/cvr\/cvm068","article-title":"FXR-mediated regulation of angiotensin type 2 receptor expression in vascular smooth muscle cells","volume":"77","author":"Zhang","year":"2008","journal-title":"Cardiovascular Research"},{"key":"10.1016\/bs.apha.2015.04.003_bb0920","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1210\/me.2008-0198","article-title":"Significance and mechanism of CYP7a1 gene regulation during the acute phase of liver regeneration","volume":"23","author":"Zhang","year":"2009","journal-title":"Molecular Endocrinology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0925","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1002\/hep.25905","article-title":"Promotion of liver regeneration\/repair by farnesoid X receptor in both liver and intestine","volume":"56","author":"Zhang","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0930","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.22342","article-title":"Orphan receptor small heterodimer partner suppresses tumorigenesis by modulating cyclin D1 expression and cellular proliferation","volume":"48","author":"Zhang","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/bs.apha.2015.04.003_bb0935","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0925-4439(03)00085-1","article-title":"Inhibition of human m-epoxide hydrolase gene expression in a case of hypercholanemia","volume":"1638","author":"Zhu","year":"2003","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/bs.apha.2015.04.003_bb0940","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cld.2007.11.010","article-title":"Mechanisms of cholestasis","volume":"12","author":"Zollner","year":"2008","journal-title":"Clinics in Liver Disease"}],"container-title":["Advances in Pharmacology","Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054358915000344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054358915000344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:03:07Z","timestamp":1778518987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054358915000344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015]]},"ISBN":["9780128031193"],"references-count":188,"URL":"https:\/\/doi.org\/10.1016\/bs.apha.2015.04.003","relation":{},"ISSN":["1054-3589"],"issn-type":[{"value":"1054-3589","type":"print"}],"subject":[],"published":{"date-parts":[[2015]]}}}