{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:03:55Z","timestamp":1790661835639,"version":"4.1.0"},"reference-count":92,"publisher":"Elsevier","isbn-type":[{"value":"9780128201879","type":"print"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/bs.apha.2020.01.002","type":"book-chapter","created":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T17:10:34Z","timestamp":1581354634000},"page":"59-82","source":"Crossref","is-referenced-by-count":37,"title":["The function and allosteric control of the human sweet taste receptor"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.apha.2020.01.002_bb0010","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.toxrep.2015.08.012","article-title":"Toxicological evaluation of the flavour ingredient 4-amino-5-(3-(isopropylamino)-2,2-dimethyl-3-oxopropoxy)-2-methylquinoline-3-carboxylic acid","volume":"2","author":"Arthur","year":"2015","journal-title":"Toxicology Reports"},{"key":"10.1016\/bs.apha.2020.01.002_bb0015","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.fct.2014.11.018","volume":"76","author":"Arthur","year":"2015","journal-title":"Food and Chemical Toxicology"},{"issue":"4","key":"10.1016\/bs.apha.2020.01.002_bb0020","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.jmb.2010.03.017","article-title":"Key amino acid residues involved in multi-point binding interactions between brazzein, a sweet protein, and the T1R2-T1R3 human sweet receptor","volume":"398","author":"Assadi-Porter","year":"2010","journal-title":"Journal of Molecular Biology"},{"issue":"10","key":"10.1016\/bs.apha.2020.01.002_bb0025","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.chembiol.2017.08.004","article-title":"Blends of non-caloric sweeteners saccharin and cyclamate show reduced off-taste due to TAS2R bitter receptor inhibition","volume":"24","author":"Behrens","year":"2017","journal-title":"Cell Chemical Biology"},{"issue":"3","key":"10.1016\/bs.apha.2020.01.002_bb0030","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.semcdb.2012.08.006","article-title":"Bitter taste receptor research comes of age: From characterization to modulation of TAS2Rs","volume":"24","author":"Behrens","year":"2013","journal-title":"Seminars in Cell & Developmental Biology"},{"issue":"4","key":"10.1016\/bs.apha.2020.01.002_bb0035","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.cub.2005.01.047","article-title":"The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception","volume":"15","author":"Bufe","year":"2005","journal-title":"Current Biology"},{"issue":"7117","key":"10.1016\/bs.apha.2020.01.002_bb0040","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nature05401","article-title":"The receptors and cells for mammalian taste","volume":"444","author":"Chandrashekar","year":"2006","journal-title":"Nature"},{"issue":"7286","key":"10.1016\/bs.apha.2020.01.002_bb0045","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/nature08783","article-title":"The cells and peripheral representation of sodium taste in mice","volume":"464","author":"Chandrashekar","year":"2010","journal-title":"Nature"},{"issue":"2","key":"10.1016\/bs.apha.2020.01.002_bb0050","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/72053","article-title":"A metabotropic glutamate receptor variant functions as a taste receptor","volume":"3","author":"Chaudhari","year":"2000","journal-title":"Nature Neuroscience"},{"issue":"1","key":"10.1016\/bs.apha.2020.01.002_bb0055","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrd2760","article-title":"Allosteric modulators of GPCRs: A novel approach for the treatment of CNS disorders","volume":"8","author":"Conn","year":"2009","journal-title":"Nature Reviews. Drug Discovery"},{"issue":"5634","key":"10.1016\/bs.apha.2020.01.002_bb0060","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.1087155","article-title":"Detection of sweet and umami taste in the absence of taste receptor T1r3","volume":"301","author":"Damak","year":"2003","journal-title":"Science"},{"issue":"15","key":"10.1016\/bs.apha.2020.01.002_bb0065","first-page":"E1416","article-title":"Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors","volume":"110","author":"Doumazane","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"Pt. B","key":"10.1016\/bs.apha.2020.01.002_bb0070","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.physbeh.2016.03.015","article-title":"Molecular mechanism of sweetness sensation","volume":"164","author":"DuBois","year":"2016","journal-title":"Physiology & Behavior"},{"key":"10.1016\/bs.apha.2020.01.002_bb0075","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1146\/annurev-food-022811-101236","article-title":"Non-caloric sweeteners, sweetness modulators, and sweetener enhancers","volume":"3","author":"DuBois","year":"2012","journal-title":"Annual Review of Food Science and Technology"},{"issue":"2","key":"10.1016\/bs.apha.2020.01.002_bb0080","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1124\/jpet.105.090886","article-title":"Analysis of allosterism in functional assays","volume":"315","author":"Ehlert","year":"2005","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"issue":"3","key":"10.1016\/bs.apha.2020.01.002_bb0085","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.foodchem.2011.07.073","article-title":"Sweeteners interacting with the transmembrane domain of the human sweet-taste receptor induce sweet-taste synergisms in binary mixtures","volume":"130","author":"Fujiwara","year":"2012","journal-title":"Food Chemistry"},{"issue":"7091","key":"10.1016\/bs.apha.2020.01.002_bb0090","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature04765","article-title":"A TAS1R receptor-based explanation of sweet \u2018water-taste\u2019","volume":"441","author":"Galindo-Cuspinera","year":"2006","journal-title":"Nature"},{"issue":"1","key":"10.1016\/bs.apha.2020.01.002_bb0095","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1124\/mol.114.097220","article-title":"Molecular insights into metabotropic glutamate receptor allosteric modulation","volume":"88","author":"Gregory","year":"2015","journal-title":"Molecular Pharmacology"},{"issue":"1","key":"10.1016\/bs.apha.2020.01.002_bb0100","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neuropharm.2010.07.007","article-title":"Allosteric modulation of metabotropic glutamate receptors: Structural insights and therapeutic potential","volume":"60","author":"Gregory","year":"2011","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/bs.apha.2020.01.002_bb0105","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1124\/jpet.113.206623","article-title":"N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement","volume":"347","author":"Gregory","year":"2013","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"issue":"4","key":"10.1016\/bs.apha.2020.01.002_bb0110","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0092-8674(00)80658-3","article-title":"Putative mammalian taste receptors: A class of taste-specific GPCRs with distinct topographic selectivity","volume":"96","author":"Hoon","year":"1999","journal-title":"Cell"},{"issue":"Pt. B","key":"10.1016\/bs.apha.2020.01.002_bb0115","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.biocel.2016.03.005","article-title":"Bitter taste receptors: Novel insights into the biochemistry and pharmacology","volume":"77","author":"Jaggupilli","year":"2016","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"issue":"15","key":"10.1016\/bs.apha.2020.01.002_bb0120","doi-asserted-by":"crossref","first-page":"15238","DOI":"10.1074\/jbc.M414287200","article-title":"Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste","volume":"280","author":"Jiang","year":"2005","journal-title":"The Journal of Biological Chemistry"},{"issue":"40","key":"10.1016\/bs.apha.2020.01.002_bb0125","doi-asserted-by":"crossref","first-page":"34296","DOI":"10.1074\/jbc.M505255200","article-title":"Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3","volume":"280","author":"Jiang","year":"2005","journal-title":"The Journal of Biological Chemistry"},{"issue":"43","key":"10.1016\/bs.apha.2020.01.002_bb0130","doi-asserted-by":"crossref","first-page":"45068","DOI":"10.1074\/jbc.M406779200","article-title":"The cysteine-rich region of T1R3 determines responses to intensely sweet proteins","volume":"279","author":"Jiang","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"issue":"4","key":"10.1016\/bs.apha.2020.01.002_bb0135","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/chemse\/19.4.349","article-title":"The effect of the sweetness inhibitor 2(-4-methoxyphenoxy)propanoic acid (sodium salt) (Na-PMP) on the taste of bitter-sweet stimuli","volume":"19","author":"Johnson","year":"1994","journal-title":"Chemical Senses"},{"key":"10.1016\/bs.apha.2020.01.002_bb0140","doi-asserted-by":"crossref","DOI":"10.1186\/1475-2891-4-5","article-title":"Sweet proteins\u2014Potential replacement for artificial low calorie sweeteners","volume":"4","author":"Kant","year":"2005","journal-title":"Nutrition Journal"},{"key":"10.1016\/bs.apha.2020.01.002_bb0145","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.toxrep.2017.09.004","article-title":"Toxicological evaluation of the flavour ingredient N-(1-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan- 2-yl)-2,6-dimethylisonicotinamide (S2218)","volume":"4","author":"Karanewsky","year":"2017","journal-title":"Toxicology Reports"},{"issue":"4","key":"10.1016\/bs.apha.2020.01.002_bb0150","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/chemse\/28.4.301","article-title":"A psychophysical investigation of binary bitter-compound interactions","volume":"28","author":"Keast","year":"2003","journal-title":"Chemical Senses"},{"issue":"11","key":"10.1016\/bs.apha.2020.01.002_bb0155","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/nrd1875","article-title":"New concepts in drug discovery: Collateral efficacy and permissive antagonism","volume":"4","author":"Kenakin","year":"2005","journal-title":"Nature Reviews. Drug Discovery"},{"issue":"10","key":"10.1016\/bs.apha.2020.01.002_bb0160","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1073\/pnas.1700001114","article-title":"Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists","volume":"114","author":"Kim","year":"2017","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/bs.apha.2020.01.002_bb0165","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/bbrc.2001.4760","article-title":"Molecular genetic identification of a candidate receptor gene for sweet taste","volume":"283","author":"Kitagawa","year":"2001","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"7742","key":"10.1016\/bs.apha.2020.01.002_bb0170","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/s41586-019-0881-4","article-title":"Structural insights into the activation of metabotropic glutamate receptors","volume":"566","author":"Koehl","year":"2019","journal-title":"Nature"},{"issue":"2","key":"10.1016\/bs.apha.2020.01.002_bb0175","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bbrc.2007.04.171","article-title":"Taste-modifying sweet protein, neoculin, is received at human T1R3 amino terminal domain","volume":"358","author":"Koizumi","year":"2007","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"40","key":"10.1016\/bs.apha.2020.01.002_bb0180","doi-asserted-by":"crossref","first-page":"16819","DOI":"10.1073\/pnas.1016644108","article-title":"Human sweet taste receptor mediates acid-induced sweetness of miraculin","volume":"108","author":"Koizumi","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"10.1016\/bs.apha.2020.01.002_bb0185","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/chemse\/25.5.555","article-title":"Neohesperidin dihydrochalcone is not a taste enhancer in aqueous sucrose solutions","volume":"25","author":"Kroeze","year":"2000","journal-title":"Chemical Senses"},{"issue":"1","key":"10.1016\/bs.apha.2020.01.002_bb0190","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1124\/jpet.112.196063","article-title":"A potent and selective metabotropic glutamate receptor 4 positive allosteric modulator improves movement in rodent models of Parkinson's disease","volume":"343","author":"Le Poul","year":"2012","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/bs.apha.2020.01.002_bb0195","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1021\/bk-2008-0979.ch023","article-title":"Functional characterization of the human sweet taste receptor: High-throughput screening assay development and structural function relation","volume":"979","author":"Li","year":"2008","journal-title":"ACS Symposium Series"},{"issue":"7","key":"10.1016\/bs.apha.2020.01.002_bb0200","doi-asserted-by":"crossref","first-page":"4692","DOI":"10.1073\/pnas.072090199","article-title":"Human receptors for sweet and umami taste","volume":"99","author":"Li","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"10.1016\/bs.apha.2020.01.002_bb0205","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/chemse\/bjv045","article-title":"Characterization of the binding site of aspartame in the human sweet taste receptor","volume":"40","author":"Maillet","year":"2015","journal-title":"Chemical Senses"},{"issue":"4","key":"10.1016\/bs.apha.2020.01.002_bb0210","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/bjp.2008.135","article-title":"Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors","volume":"154","author":"Malherbe","year":"2008","journal-title":"British Journal of Pharmacology"},{"issue":"8","key":"10.1016\/bs.apha.2020.01.002_bb0215","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1523\/JNEUROSCI.4329-05.2006","article-title":"Umami responses in mouse taste cells indicate more than one receptor","volume":"26","author":"Maruyama","year":"2006","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"10.1016\/bs.apha.2020.01.002_bb0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035380","article-title":"Characterization of the modes of binding between human sweet taste receptor and low-molecular-weight sweet compounds","volume":"7","author":"Masuda","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/bs.apha.2020.01.002_bb0225","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.biochi.2013.01.010","article-title":"Five amino acid residues in cysteine-rich domain of human T1R3 were involved in the response for sweet-tasting protein, thaumatin","volume":"95","author":"Masuda","year":"2013","journal-title":"Biochimie"},{"issue":"1","key":"10.1016\/bs.apha.2020.01.002_bb0230","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/ng0501-58","article-title":"Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac","volume":"28","author":"Max","year":"2001","journal-title":"Nature Genetics"},{"issue":"2","key":"10.1016\/bs.apha.2020.01.002_bb0235","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1093\/chemse\/bjp092","article-title":"The molecular receptive ranges of human TAS2R bitter taste receptors","volume":"35","author":"Meyerhof","year":"2010","journal-title":"Chemical Senses"},{"issue":"Suppl. 1","key":"10.1016\/bs.apha.2020.01.002_bb0240","doi-asserted-by":"crossref","first-page":"i14","DOI":"10.1093\/chemse\/bjh089","article-title":"Human bitter taste perception","volume":"30","author":"Meyerhof","year":"2005","journal-title":"Chemical Senses"},{"issue":"1","key":"10.1016\/bs.apha.2020.01.002_bb0245","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/emboj.2010.270","article-title":"Trans-activation between 7TM domains: Implication in heterodimeric GABAB receptor activation","volume":"30","author":"Monnier","year":"2011","journal-title":"The EMBO Journal"},{"issue":"5","key":"10.1016\/bs.apha.2020.01.002_bb0250","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/87440","article-title":"A candidate taste receptor gene near a sweet taste locus","volume":"4","author":"Montmayeur","year":"2001","journal-title":"Nature Neuroscience"},{"issue":"3","key":"10.1016\/bs.apha.2020.01.002_bb0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0213552","article-title":"Structural insights into the differences among lactisole derivatives in inhibitory mechanisms against the human sweet taste receptor","volume":"14","author":"Nakagita","year":"2019","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/bs.apha.2020.01.002_bb0260","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1096\/fj.07-100289","article-title":"Acid-induced sweetness of neoculin is ascribed to its pH-dependent agonistic-antagonistic interaction with human sweet taste receptor","volume":"22","author":"Nakajima","year":"2008","journal-title":"FASEB Journal"},{"issue":"6877","key":"10.1016\/bs.apha.2020.01.002_bb0265","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature726","article-title":"An amino-acid taste receptor","volume":"416","author":"Nelson","year":"2002","journal-title":"Nature"},{"issue":"3","key":"10.1016\/bs.apha.2020.01.002_bb0270","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0092-8674(01)00451-2","article-title":"Mammalian sweet taste receptors","volume":"106","author":"Nelson","year":"2001","journal-title":"Cell"},{"issue":"2","key":"10.1016\/bs.apha.2020.01.002_bb0275","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1124\/jpet.103.057273","article-title":"Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl","volume":"308","author":"Nemeth","year":"2004","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"issue":"21","key":"10.1016\/bs.apha.2020.01.002_bb0280","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1016\/j.cub.2005.09.037","article-title":"Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli","volume":"15","author":"Nie","year":"2005","journal-title":"Current Biology: CB"},{"issue":"5","key":"10.1016\/bs.apha.2020.01.002_bb0285","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1124\/mol.117.110114","article-title":"Differential pharmacology and binding of mGlu2 receptor allosteric modulators","volume":"93","author":"O'Brien","year":"2018","journal-title":"Molecular Pharmacology"},{"issue":"4","key":"10.1016\/bs.apha.2020.01.002_bb0290","first-page":"R960","article-title":"Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity","volume":"296","author":"Ohkuri","year":"2009","journal-title":"American Journal of Physiology"},{"issue":"7438","key":"10.1016\/bs.apha.2020.01.002_bb0295","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature11905","article-title":"High salt recruits aversive taste pathways","volume":"494","author":"Oka","year":"2013","journal-title":"Nature"},{"issue":"7631","key":"10.1016\/bs.apha.2020.01.002_bb0300","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nature20566","article-title":"Organization and functions of mGlu and GABAB receptor complexes","volume":"540","author":"Pin","year":"2016","journal-title":"Nature"},{"key":"10.1016\/bs.apha.2020.01.002_bb0305","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.mce.2019.02.019","article-title":"GPCR interaction as a possible way for allosteric control between receptors","volume":"486","author":"Pin","year":"2019","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"5","key":"10.1016\/bs.apha.2020.01.002_bb0310","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1124\/mol.105.016162","article-title":"Allosteric modulation of the cannabinoid CB1 receptor","volume":"68","author":"Price","year":"2005","journal-title":"Molecular Pharmacology"},{"issue":"16","key":"10.1016\/bs.apha.2020.01.002_bb0315","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/j.cub.2007.07.046","article-title":"Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin","volume":"17","author":"Pronin","year":"2007","journal-title":"Current Biology: CB"},{"issue":"8","key":"10.1016\/bs.apha.2020.01.002_bb0320","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/chemse\/bjz056","article-title":"Evaluation of sweetener synergy in humans by isobole analyses","volume":"44","author":"Reyes","year":"2019","journal-title":"Chemical Senses"},{"issue":"7","key":"10.1016\/bs.apha.2020.01.002_bb0325","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1002\/dneu.20403","article-title":"The G-protein coupling properties of the human sweet and amino acid taste receptors","volume":"67","author":"Sainz","year":"2007","journal-title":"Developmental Neurobiology"},{"issue":"3","key":"10.1016\/bs.apha.2020.01.002_bb0330","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1046\/j.1471-4159.2001.00292.x","article-title":"Identification of a novel member of the T1R family of putative taste receptors","volume":"77","author":"Sainz","year":"2001","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/bs.apha.2020.01.002_bb0335","doi-asserted-by":"crossref","DOI":"10.1038\/srep22807","article-title":"Intracellular acidification is required for full activation of the sweet taste receptor by miraculin","volume":"6","author":"Sanematsu","year":"2016","journal-title":"Scientific Reports"},{"issue":"2","key":"10.1016\/bs.apha.2020.01.002_bb0340","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0361-9230(95)00062-J","article-title":"Investigation of synergism in binary mixtures of sweeteners","volume":"38","author":"Schiffman","year":"1995","journal-title":"Brain Research Bulletin"},{"issue":"4","key":"10.1016\/bs.apha.2020.01.002_bb0345","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/chemse\/24.4.439","article-title":"Selective inhibition of sweetness by the sodium salt of +\/\u22122-(4-methoxyphenoxy)propanoic acid","volume":"24","author":"Schiffman","year":"1999","journal-title":"Chemical Senses"},{"issue":"2","key":"10.1016\/bs.apha.2020.01.002_bb0350","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/chemse\/25.2.131","article-title":"Synergism among ternary mixtures of fourteen sweeteners","volume":"25","author":"Schiffman","year":"2000","journal-title":"Chemical Senses"},{"issue":"9","key":"10.1016\/bs.apha.2020.01.002_bb0355","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.15252\/embr.201540530","article-title":"Ins and outs of GPCR signaling in primary cilia","volume":"16","author":"Schou","year":"2015","journal-title":"EMBO Reports"},{"key":"10.1016\/bs.apha.2020.01.002_bb0360","doi-asserted-by":"crossref","unstructured":"Servant, G., & Servant, N. (2019). 10,281,467. U. S. P. Office.","DOI":"10.3917\/rfp.831.0281"},{"key":"10.1016\/bs.apha.2020.01.002_bb0365","first-page":"1","article-title":"The sweet taste of true synergy: Positive allosteric modulation of the human sweet taste receptor","volume":"904","author":"Servant","year":"2011","journal-title":"Trends in Pharmacological Sciences"},{"issue":"10","key":"10.1016\/bs.apha.2020.01.002_bb0370","doi-asserted-by":"crossref","first-page":"4746","DOI":"10.1073\/pnas.0911670107","article-title":"Positive allosteric modulators of the human sweet taste receptor enhance sweet taste","volume":"107","author":"Servant","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"10.1016\/bs.apha.2020.01.002_bb0375","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0124030","article-title":"Modulation of sweet taste by umami compounds via sweet taste receptor subunit hT1R2","volume":"10","author":"Shim","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/bs.apha.2020.01.002_bb0380","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00253-012-4387-3","article-title":"Sweet-taste-suppressing compounds: Current knowledge and perspectives of application","volume":"96","author":"Sigoillot","year":"2012","journal-title":"Applied Microbiology and Biotechnology"},{"key":"10.1016\/bs.apha.2020.01.002_bb0385","unstructured":"Slack, J. P. (2012). 8,124,360. U. S. P. Office."},{"issue":"12","key":"10.1016\/bs.apha.2020.01.002_bb0390","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.cub.2010.04.043","article-title":"Modulation of bitter taste perception by a small molecule hTAS2R antagonist","volume":"20","author":"Slack","year":"2010","journal-title":"Current Biology: CB"},{"key":"10.1016\/bs.apha.2020.01.002_bb0395","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.foodres.2019.03.019","article-title":"Temporal sweetness and side tastes profiles of 16 sweeteners using temporal check-all-that-apply (TCATA)","volume":"121","author":"Tan","year":"2019","journal-title":"Food Research International"},{"key":"10.1016\/bs.apha.2020.01.002_bb0400","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1016\/j.cub.2019.08.077","article-title":"Cellular and neural responses to sour stimuli require the proton channel Otop1","volume":"29","author":"Teng","year":"2019","journal-title":"Current Biology"},{"issue":"6379","key":"10.1016\/bs.apha.2020.01.002_bb0405","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1126\/science.aao3264","article-title":"An evolutionarily conserved gene family encodes proton-selective ion channels","volume":"359","author":"Tu","year":"2018","journal-title":"Science"},{"issue":"7","key":"10.1016\/bs.apha.2020.01.002_bb0410","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/jps.3030440717","article-title":"A taste panel study of cyclamate-saccharin mixture and of its components","volume":"44","author":"Vincent","year":"1955","journal-title":"Journal of the American Pharmaceutical Association. American Pharmaceutical Association"},{"issue":"26","key":"10.1016\/bs.apha.2020.01.002_bb0415","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1021\/jf062359y","article-title":"Interactions of the sweet protein brazzein with the sweet taste receptor","volume":"54","author":"Walters","year":"2006","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"10.1016\/bs.apha.2020.01.002_bb0420","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1472-6807-7-66","article-title":"The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor","volume":"7","author":"Winnig","year":"2007","journal-title":"BMC Structural Biology"},{"key":"10.1016\/bs.apha.2020.01.002_bb0425","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/1471-2202-6-22","article-title":"Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor","volume":"6","author":"Winnig","year":"2005","journal-title":"BMC Neuroscience"},{"issue":"39","key":"10.1016\/bs.apha.2020.01.002_bb0430","doi-asserted-by":"crossref","first-page":"14258","DOI":"10.1073\/pnas.0404384101","article-title":"Different functional roles of T1R subunits in the heteromeric taste receptors","volume":"101","author":"Xu","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"10.1016\/bs.apha.2020.01.002_bb0435","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1113\/jphysiol.2011.211920","article-title":"Umami taste in mice uses multiple receptors and transduction pathways","volume":"590","author":"Yasumatsu","year":"2012","journal-title":"The Journal of Physiology"},{"issue":"13","key":"10.1016\/bs.apha.2020.01.002_bb0440","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1073\/pnas.1100495108","article-title":"Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells","volume":"108","author":"Yee","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.apha.2020.01.002_bb0445","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.cell.2019.08.031","article-title":"Sour sensing from the tongue to the brain","volume":"179","author":"Zhang","year":"2019","journal-title":"Cell"},{"issue":"10","key":"10.1016\/bs.apha.2020.01.002_bb0450","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1073\/pnas.0911660107","article-title":"Molecular mechanism of the sweet taste enhancers","volume":"107","author":"Zhang","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"52","key":"10.1016\/bs.apha.2020.01.002_bb0455","doi-asserted-by":"crossref","first-page":"20930","DOI":"10.1073\/pnas.0810174106","article-title":"Molecular mechanism for the umami taste synergism","volume":"105","author":"Zhang","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"10.1016\/bs.apha.2020.01.002_bb0460","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s12031-018-1156-5","article-title":"The heptahelical domain of the sweet taste receptor T1R2 is a new allosteric binding site for the sweet taste modulator amiloride that modulates sweet taste in a species-dependent manner","volume":"66","author":"Zhao","year":"2018","journal-title":"Journal of Molecular Neuroscience"},{"issue":"3","key":"10.1016\/bs.apha.2020.01.002_bb0465","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0092-8674(03)00844-4","article-title":"The receptors for mammalian sweet and umami taste","volume":"115","author":"Zhao","year":"2003","journal-title":"Cell"}],"container-title":["Advances in Pharmacology","From Structure to Clinical Development: Allosteric Modulation of G Protein-Coupled Receptors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054358920300028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054358920300028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:45:58Z","timestamp":1760960758000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054358920300028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9780128201879"],"references-count":92,"URL":"https:\/\/doi.org\/10.1016\/bs.apha.2020.01.002","relation":{},"ISSN":["1054-3589"],"issn-type":[{"value":"1054-3589","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]}}}