{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T13:20:46Z","timestamp":1779196846644,"version":"3.51.4"},"reference-count":82,"publisher":"Elsevier","isbn-type":[{"value":"9780443313585","type":"print"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/bs.apha.2024.10.001","type":"book-chapter","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T15:02:22Z","timestamp":1729004542000},"page":"265-285","source":"Crossref","is-referenced-by-count":1,"title":["Targeting glutamate carboxypeptidase II in IBD"],"prefix":"10.1016","member":"78","reference":[{"issue":"5","key":"10.1016\/bs.apha.2024.10.001_bib1","first-page":"309","volume":"6","year":"2010","journal-title":"Gastroenterol Hepatol (N Y)"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.001_bib2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/bju.13739","volume":"120","author":"Albisinni","year":"2017","journal-title":"BJU International"},{"issue":"7","key":"10.1016\/bs.apha.2024.10.001_bib3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S2468-1253(21)00065-0","article-title":"Breaking the therapeutic ceiling in drug development in ulcerative colitis","volume":"6","author":"Alsoud","year":"2021","journal-title":"The Lancet Gastroenterology & Hepatology"},{"issue":"7","key":"10.1016\/bs.apha.2024.10.001_bib4","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1136\/gutjnl-2021-326451","article-title":"Biopsy and blood-based molecular biomarker of inflammation in IBD","volume":"72","author":"Argmann","year":"2023","journal-title":"Gut"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.001_bib5","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s003350010240","article-title":"Cloning, expression, genomic localization, and enzymatic activities of the mouse homolog of prostate-specific membrane antigen\/NAALADase\/folate hydrolase","volume":"12","author":"Bacich","year":"2001","journal-title":"Mammalian Genome: Official Journal of the International Mammalian Genome Society"},{"issue":"6","key":"10.1016\/bs.apha.2024.10.001_bib6","doi-asserted-by":"crossref","first-page":"856","DOI":"10.2174\/092986712799034888","article-title":"Glutamate carboxypeptidase II in diagnosis and treatment of neurologic disorders and prostate cancer","volume":"19","author":"Barinka","year":"2012","journal-title":"Current Medicinal Chemistry"},{"issue":"12","key":"10.1016\/bs.apha.2024.10.001_bib7","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1097\/01.MIB.0000437045.26036.00","article-title":"Gene expression profiles of ileal inflammatory bowel disease correlate with disease phenotype and advance understanding of its immunopathogenesis","volume":"19","author":"Ben-Shachar","year":"2013","journal-title":"Inflammatory Bowel Diseases"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.001_bib8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF01181553","article-title":"N-acetylated alpha-linked acidic dipeptidase is expressed by non-myelinating Schwann cells in the peripheral nervous system","volume":"24","author":"Berger","year":"1995","journal-title":"Journal of Neurocytology"},{"issue":"9","key":"10.1016\/bs.apha.2024.10.001_bib9","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/BF02284818","article-title":"N-acetylated alpha-linked acidic dipeptidase may be involved in axon-Schwann cell signalling","volume":"25","author":"Berger","year":"1996","journal-title":"Journal of Neurocytology"},{"issue":"1","key":"10.1016\/bs.apha.2024.10.001_bib10","doi-asserted-by":"crossref","first-page":"4254","DOI":"10.1038\/s41598-018-22594-1","article-title":"PSMA expression: a potential ally for the pathologist in prostate cancer diagnosis","volume":"8","author":"Bravaccini","year":"2018","journal-title":"Scientific Reports"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.001_bib11","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1073\/pnas.93.2.749","article-title":"Prostate-specific membrane antigen is a hydrolase with substrate and pharmacologic characteristics of a neuropeptidase","volume":"93","author":"Carter","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.001_bib12","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s13139-021-00732-4","article-title":"[68 Ga]Ga-PSMA-11 small bowel uptake in Crohn\u2019s disease: Revisiting the \u201cnon-specificity\u201d of PSMA ligands","volume":"56","author":"Chandekar","year":"2022","journal-title":"Nuclear Medicine and Molecular Imaging"},{"key":"10.1016\/bs.apha.2024.10.001_bib13","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fmed.2018.00032","article-title":"Emerging mechanisms of innate immunity and their translational potential in inflammatory bowel disease","volume":"5","author":"Corridoni","year":"2018","journal-title":"Frontiers in Medicine (Lausanne)"},{"issue":"10","key":"10.1016\/bs.apha.2024.10.001_bib14","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1021\/acs.molpharmaceut.9b00637","article-title":"Enhanced oral bioavailability of 2-(phosphonomethyl)-pentanedioic acid (2-PMPA) from its (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl (ODOL)-based prodrugs","volume":"16","author":"Dash","year":"2019","journal-title":"Molecular Pharmaceutics"},{"key":"10.1016\/bs.apha.2024.10.001_bib15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jconrel.2017.01.036","article-title":"Local enema treatment to inhibit FOLH1\/GCPII as a novel therapy for inflammatory bowel disease","volume":"263","author":"Date","year":"2017","journal-title":"Journal of Controlled Release: Official Journal of the Controlled Release Society"},{"issue":"6","key":"10.1016\/bs.apha.2024.10.001_bib16","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1194\/jlr.R054114","article-title":"Intestinal transport and metabolism of bile acids","volume":"56","author":"Dawson","year":"2015","journal-title":"Journal of Lipid Research"},{"key":"10.1016\/bs.apha.2024.10.001_bib17","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.5604\/01.3001.0010.5493","article-title":"Bile acid physiology","volume":"16","author":"Di Ciaula","year":"2017","journal-title":"Annals of Hepatology"},{"issue":"4","key":"10.1016\/bs.apha.2024.10.001_bib18","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1136\/gutjnl-2012-302578","article-title":"Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases","volume":"62","author":"Duboc","year":"2013","journal-title":"Gut"},{"key":"10.1016\/bs.apha.2024.10.001_bib19","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.3389\/fphar.2018.01382","article-title":"Pharmacological applications of bile acids and their derivatives in the treatment of metabolic syndrome","volume":"9","author":"Ethanic","year":"2018","journal-title":"Frontiers in Pharmacology"},{"issue":"4","key":"10.1016\/bs.apha.2024.10.001_bib20","doi-asserted-by":"crossref","first-page":"424","DOI":"10.21147\/j.issn.1000-9604.2023.04.08","article-title":"Focal ablation therapy presents promising results for selectively localized prostate cancer patients","volume":"35","author":"Feng","year":"2023","journal-title":"Chinese Journal of Cancer Research"},{"key":"10.1016\/bs.apha.2024.10.001_bib21","article-title":"Breaking through the therapeutic ceiling of inflammatory bowel disease: Dual-targeted therapies","volume":"158","author":"Feng","year":"2023","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"issue":"9","key":"10.1016\/bs.apha.2024.10.001_bib22","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.2174\/092986712799462658","article-title":"Structure-activity relationships of glutamate carboxypeptidase II (GCPII) inhibitors","volume":"19","author":"Ferraris","year":"2012","journal-title":"Current Medicinal Chemistry"},{"issue":"3","key":"10.1016\/bs.apha.2024.10.001_bib23","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/jcb.10661","article-title":"Tumor target prostate specific membrane antigen (PSMA) and its regulation in prostate cancer","volume":"91","author":"Ghosh","year":"2004","journal-title":"Journal of Cellular Biochemistry"},{"issue":"1","key":"10.1016\/bs.apha.2024.10.001_bib24","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41467-018-07841-3","article-title":"Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response","volume":"10","author":"Haberman","year":"2019","journal-title":"Nature Communications"},{"issue":"8","key":"10.1016\/bs.apha.2024.10.001_bib25","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1172\/JCI75436","article-title":"Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature","volume":"124","author":"Haberman","year":"2014","journal-title":"The Journal of Clinical Investigation"},{"issue":"32","key":"10.1016\/bs.apha.2024.10.001_bib26","doi-asserted-by":"crossref","first-page":"20417","DOI":"10.1074\/jbc.273.32.20417","article-title":"Folylpoly-gamma-glutamate carboxypeptidase from pig jejunum. Molecular characterization and relation to glutamate carboxypeptidase II","volume":"273","author":"Halsted","year":"1998","journal-title":"The Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.001_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1586\/ecp.12.2","article-title":"Mesalamine in the treatment and maintenance of remission of ulcerative colitis","volume":"5","author":"Ham","year":"2012","journal-title":"Expert Review of Clinical Pharmacology"},{"issue":"1","key":"10.1016\/bs.apha.2024.10.001_bib28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s40168-019-0689-3","article-title":"Systematic assessment of secondary bile acid metabolism in gut microbes reveals distinct metabolic capabilities in inflammatory bowel disease","volume":"7","author":"Heinken","year":"2019","journal-title":"Microbiome"},{"issue":"3A Suppl","key":"10.1016\/bs.apha.2024.10.001_bib29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0090-4295(97)00177-5","article-title":"Characterization and glutamyl preferring carboxypeptidase function of prostate specific membrane antigen: a novel folate hydrolase","volume":"49","author":"Heston","year":"1997","journal-title":"Urology"},{"key":"10.1016\/bs.apha.2024.10.001_bib30","series-title":"Proteinases as drug targets","article-title":"Glutamate carboxypeptidase II as a therapeutic target","author":"Hlouchov\u00e1","year":"2011"},{"issue":"13","key":"10.1016\/bs.apha.2024.10.001_bib31","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15133402","article-title":"The impact of PSMA PET\/CT on modern prostate cancer management and decision making-the urological perspective","volume":"15","author":"Hoffman","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"10","key":"10.1016\/bs.apha.2024.10.001_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102020","article-title":"The innate and adaptive immune system as targets for biologic therapies in inflammatory bowel disease","volume":"18","author":"Holleran","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.001_bib33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.7150\/ntno.63158","article-title":"Dendrimer-2PMPA selectively blocks upregulated microglial GCPII activity and improves cognition in a mouse model of multiple sclerosis","volume":"6","author":"Hollinger","year":"2022","journal-title":"Nanotheranostics"},{"issue":"10","key":"10.1016\/bs.apha.2024.10.001_bib34","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1093\/ibd\/izaa210","article-title":"Defining the path forward for biomarkers to address unmet needs in inflammatory bowel diseases","volume":"26","author":"Honig","year":"2020","journal-title":"Inflammatory Bowel Diseases"},{"issue":"5B","key":"10.1016\/bs.apha.2024.10.001_bib35","first-page":"927","article-title":"Monoclonal antibodies to a new antigenic marker in epithelial prostatic cells and serum of prostatic cancer patients","volume":"7","author":"Horoszewicz","year":"1987","journal-title":"Anticancer Research"},{"issue":"12","key":"10.1016\/bs.apha.2024.10.001_bib36","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1007\/s00261-023-04002-z","article-title":"PSMA PET imaging in the diagnosis and management of prostate cancer","volume":"48","author":"Houshmand","year":"2023","journal-title":"Abdominal Radiology (NY)"},{"key":"10.1016\/bs.apha.2024.10.001_bib37","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2147\/CEG.S404009","article-title":"PSMA-targeted PET radiotracer [(18)F]DCFPyL as an imaging biomarker in inflammatory bowel disease","volume":"16","author":"Ismail","year":"2023","journal-title":"Clinical and Experimental Gastroenterology"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.001_bib38","first-page":"227","article-title":"Molecular cloning of a complementary DNA encoding a prostate-specific membrane antigen","volume":"53","author":"Israeli","year":"1993","journal-title":"Cancer Research"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.001_bib39","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1021\/jm950801q","article-title":"Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated alpha-linked acidic dipeptidase","volume":"39","author":"Jackson","year":"1996","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/bs.apha.2024.10.001_bib40","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.3389\/fimmu.2018.02764","article-title":"Dynamics of colon monocyte and macrophage activation during colitis","volume":"9","author":"Jones","year":"2018","journal-title":"Frontiers in Immunology"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.001_bib41","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.vascn.2003.12.002","article-title":"Animal models of inflammatory bowel disease","volume":"50","author":"Jurjus","year":"2004","journal-title":"Journal of Pharmacological and Toxicological Methods"},{"issue":"5","key":"10.1016\/bs.apha.2024.10.001_bib42","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1016\/j.cgh.2022.02.044","article-title":"Net remission rates with biologic treatment in Crohn\u2019s disease: A reappraisal of the clinical trial data","volume":"21","author":"Kayal","year":"2023","journal-title":"Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association"},{"issue":"4","key":"10.1016\/bs.apha.2024.10.001_bib43","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/s00268-005-0544-5","article-title":"Expression of prostate-specific membrane antigen in normal and malignant human tissues","volume":"30","author":"Kinoshita","year":"2006","journal-title":"World Journal of Surgery"},{"issue":"1","key":"10.1016\/bs.apha.2024.10.001_bib44","doi-asserted-by":"crossref","first-page":"e54","DOI":"10.1097\/RLU.0000000000002370","article-title":"68Ga-PSMA uptake in anal fistula on PET\/CT scan","volume":"44","author":"Klingenberg","year":"2019","journal-title":"Clinical Nuclear Medicine"},{"issue":"4","key":"10.1016\/bs.apha.2024.10.001_bib45","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1159\/000199367","article-title":"Altered fecal bile acid pattern in patients with inflammatory bowel disease","volume":"35","author":"Kruis","year":"1986","journal-title":"Digestion"},{"key":"10.1016\/bs.apha.2024.10.001_bib46","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jconrel.2015.04.040","article-title":"Enema ion compositions for enhancing colorectal drug delivery","volume":"209","author":"Maisel","year":"2015","journal-title":"Journal of Controlled Release: Official Journal of the Controlled Release Society"},{"issue":"6","key":"10.1016\/bs.apha.2024.10.001_bib47","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.1021\/acs.jmedchem.6b00062","article-title":"Discovery of orally available prodrugs of the glutamate carboxypeptidase II (GCPII) inhibitor 2-phosphonomethylpentanedioic acid (2-PMPA)","volume":"59","author":"Majer","year":"2016","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/bs.apha.2024.10.001_bib48","article-title":"A systematic review and meta-analysis to evaluate the diagnostic accuracy of PSMA PET\/CT in the initial staging of prostate cancer","author":"Mari","year":"2024","journal-title":"Prostate Cancer and Prostatic Diseases"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.001_bib49","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.intimp.2012.11.017","article-title":"Dose-dependent antiinflammatory effect of ursodeoxycholic acid in experimental colitis","volume":"15","author":"Martinez-Moya","year":"2013","journal-title":"International Immunopharmacology"},{"issue":"6","key":"10.1016\/bs.apha.2024.10.001_bib50","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1038\/sj.emboj.7600969","article-title":"Structure of glutamate carboxypeptidase II, a drug target in neuronal damage and prostate cancer","volume":"25","author":"Mesters","year":"2006","journal-title":"The EMBO Journal"},{"issue":"4","key":"10.1016\/bs.apha.2024.10.001_bib51","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1111\/j.1365-2559.2007.02635.x","article-title":"Prostate-specific membrane antigen (PSMA) protein expression in normal and neoplastic tissues and its sensitivity and specificity in prostate adenocarcinoma: An immunohistochemical study using mutiple tumour tissue microarray technique","volume":"50","author":"Mhawech-Fauceglia","year":"2007","journal-title":"Histopathology"},{"issue":"3","key":"10.1016\/bs.apha.2024.10.001_bib52","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/BF03190714","article-title":"Pharmacology of bile acids and their derivatives: Absorption promoters and therapeutic agents","volume":"31","author":"Mikov","year":"2006","journal-title":"European Journal of Drug Metabolism and Pharmacokinetics"},{"issue":"10","key":"10.1016\/bs.apha.2024.10.001_bib53","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1021\/acs.molpharmaceut.7b00231","article-title":"Enhanced brain delivery of 2-(phosphonomethyl)pentanedioic acid following intranasal administration of its gamma-substituted ester prodrugs","volume":"14","author":"Nedelcovych","year":"2017","journal-title":"Molecular Pharmaceutics"},{"issue":"10","key":"10.1016\/bs.apha.2024.10.001_bib54","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1002\/ibd.21263","article-title":"Characterization of intestinal gene expression profiles in Crohn\u2019s disease by genome-wide microarray analysis","volume":"16","author":"Noble","year":"2010","journal-title":"Inflammatory Bowel Diseases"},{"issue":"1-2","key":"10.1016\/bs.apha.2024.10.001_bib55","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0167-4781(98)00200-0","article-title":"Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene","volume":"1443","author":"O\u2019Keefe","year":"1998","journal-title":"Biochimica et Biophysica Acta"},{"issue":"5","key":"10.1016\/bs.apha.2024.10.001_bib56","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/ibd\/izab311","article-title":"Meta-analysis of IBD gut samples gene expression identifies specific markers of ileal and colonic diseases","volume":"28","author":"Perez","year":"2022","journal-title":"Inflammatory Bowel Diseases"},{"issue":"3","key":"10.1016\/bs.apha.2024.10.001_bib57","article-title":"Spontaneous loss-of-function Dock2 mutation alters murine colitis sensitivity and is a confounding variable in inflammatory bowel disease research","volume":"1","author":"Peters","year":"2019","journal-title":"Crohn\u2019s & Colitis 360"},{"issue":"708","key":"10.1016\/bs.apha.2024.10.001_bib58","doi-asserted-by":"crossref","first-page":"eabn7491","DOI":"10.1126\/scitranslmed.abn7491","article-title":"A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis","volume":"15","author":"Peters","year":"2023","journal-title":"Science Translational Medicine"},{"issue":"9","key":"10.1016\/bs.apha.2024.10.001_bib59","first-page":"1445","article-title":"Prostate-specific membrane antigen: A novel folate hydrolase in human prostatic carcinoma cells","volume":"2","author":"Pinto","year":"1996","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"12","key":"10.1016\/bs.apha.2024.10.001_bib60","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.88634","article-title":"FOLH1\/GCPII is elevated in IBD patients, and its inhibition ameliorates murine IBD abnormalities","volume":"1","author":"Rais","year":"2016","journal-title":"JCI Insight"},{"issue":"30","key":"10.1016\/bs.apha.2024.10.001_bib61","doi-asserted-by":"crossref","first-page":"14498","DOI":"10.1016\/S0021-9258(18)47823-4","article-title":"Hydrolysis of the brain dipeptide N-acetyl-L-aspartyl-L-glutamate. Identification and characterization of a novel N-acetylated alpha-linked acidic dipeptidase activity from rat brain","volume":"262","author":"Robinson","year":"1987","journal-title":"The Journal of Biological Chemistry"},{"issue":"3","key":"10.1016\/bs.apha.2024.10.001_bib62","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0014-2999(86)90291-8","article-title":"Quisqualate selectively inhibits a brain peptidase which cleaves N-acetyl-L-aspartyl-L-glutamate in vitro","volume":"130","author":"Robinson","year":"1986","journal-title":"European Journal of Pharmacology"},{"issue":"5","key":"10.1016\/bs.apha.2024.10.001_bib63","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1159\/000530389","article-title":"Dendrimer-conjugated glutamate carboxypeptidase II inhibitor restores microglial changes in a rabbit model of cerebral palsy","volume":"45","author":"Sah","year":"2023","journal-title":"Developmental Neuroscience"},{"issue":"1","key":"10.1016\/bs.apha.2024.10.001_bib64","first-page":"81","article-title":"Prostate-specific membrane antigen expression in normal and malignant human tissues","volume":"3","author":"Silver","year":"1997","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"4","key":"10.1016\/bs.apha.2024.10.001_bib65","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.chom.2020.01.021","article-title":"Dysbiosis-induced secondary bile acid deficiency promotes intestinal inflammation","volume":"27","author":"Sinha","year":"2020","journal-title":"Cell Host & Microbe"},{"key":"10.1016\/bs.apha.2024.10.001_bib66","series-title":"Handbook of Proteolytic Enzymes (Third Edition)","first-page":"1620","article-title":"Chapter 367 - Glutamate Carboxypeptidase II","author":"Slusher","year":"2013"},{"issue":"34","key":"10.1016\/bs.apha.2024.10.001_bib67","doi-asserted-by":"crossref","first-page":"21297","DOI":"10.1016\/S0021-9258(17)45359-2","article-title":"Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterization","volume":"265","author":"Slusher","year":"1990","journal-title":"The Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.001_bib68","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/cne.903150208","article-title":"Immunocytochemical localization of the N-acetyl-aspartyl-glutamate (NAAG) hydrolyzing enzyme N-acetylated alpha-linked acidic dipeptidase (NAALADase)","volume":"315","author":"Slusher","year":"1992","journal-title":"The Journal of Comparative Neurology"},{"issue":"1","key":"10.1016\/bs.apha.2024.10.001_bib69","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/(SICI)1097-0045(19990401)39:1<28::AID-PROS5>3.0.CO;2-A","article-title":"Characterization of the enzymatic activity of PSM: Comparison with brain NAALADase","volume":"39","author":"Tiffany","year":"1999","journal-title":"The Prostate"},{"issue":"1","key":"10.1016\/bs.apha.2024.10.001_bib70","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/1078-1439(95)00004-2","article-title":"Biochemical characterization and mapping of the 7E11-C5.3 epitope of the prostate-specific membrane antigen","volume":"1","author":"Troyer","year":"1995","journal-title":"Urologic Oncology"},{"issue":"7","key":"10.1016\/bs.apha.2024.10.001_bib71","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.02766-16","article-title":"Ursodeoxycholic acid and its taurine- or glycine-conjugated species reduce colitogenic dysbiosis and equally suppress experimental colitis in mice","volume":"83","author":"Van Den Bossche","year":"2017","journal-title":"Applied and Environmental Microbiology"},{"issue":"4","key":"10.1016\/bs.apha.2024.10.001_bib72","doi-asserted-by":"crossref","first-page":"648","DOI":"10.2741\/4742","article-title":"GCPII and its close homolog GCPIII: from a neuropeptidase to a cancer marker and beyond","volume":"24","author":"Vorlova","year":"2019","journal-title":"Frontiers in Bioscience (Landmark Ed)"},{"key":"10.1016\/bs.apha.2024.10.001_bib73","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/bs.apha.2016.01.007","article-title":"Still NAAG\u2019ing after all these years: The continuing pursuit of GCPII inhibitors","volume":"76","author":"Vornov","year":"2016","journal-title":"Advances in Pharmacology"},{"issue":"29","key":"10.1016\/bs.apha.2024.10.001_bib74","doi-asserted-by":"crossref","first-page":"9952","DOI":"10.3748\/wjg.v20.i29.9952","article-title":"Therapeutic uses of animal biles in traditional Chinese medicine: An ethnopharmacological, biophysical chemical and medicinal review","volume":"20","author":"Wang","year":"2014","journal-title":"World Journal of Gastroenterology: WJG"},{"issue":"5","key":"10.1016\/bs.apha.2024.10.001_bib75","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.cell.2019.10.015","article-title":"Long-term culture captures injury-repair cycles of colonic stem cells","volume":"179","author":"Wang","year":"2019","journal-title":"Cell"},{"issue":"6","key":"10.1016\/bs.apha.2024.10.001_bib76","doi-asserted-by":"crossref","first-page":"G550","DOI":"10.1152\/ajpgi.00256.2016","article-title":"Ursodeoxycholic acid and lithocholic acid exert anti-inflammatory actions in the colon","volume":"312","author":"Ward","year":"2017","journal-title":"American Journal of Physiology. Gastrointestinal and Liver Physiology"},{"issue":"1","key":"10.1016\/bs.apha.2024.10.001_bib77","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/1078-1439(95)00002-Y","article-title":"Expression of prostate-specific membrane antigen in normal, benign, and malignant prostate tissues","volume":"1","author":"Wright","year":"1995","journal-title":"Urologic Oncology"},{"issue":"5","key":"10.1016\/bs.apha.2024.10.001_bib78","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1136\/gutjnl-2014-307387","article-title":"Gene expression alterations in ulcerative colitis patients after restorative proctocolectomy extend to the small bowel proximal to the pouch","volume":"64","author":"Yanai","year":"2015","journal-title":"Gut"},{"key":"10.1016\/bs.apha.2024.10.001_bib79","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jconrel.2023.04.017","article-title":"Dendrimer-enabled targeted delivery attenuates glutamate excitotoxicity and improves motor function in a rabbit model of cerebral palsy","volume":"358","author":"Zhang","year":"2023","journal-title":"Journal of Controlled Release: Official Journal of the Controlled Release Society"},{"issue":"5","key":"10.1016\/bs.apha.2024.10.001_bib80","article-title":"An ileal Crohn\u2019s disease gene signature based on whole human genome expression profiles of disease unaffected ileal mucosal biopsies","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/bs.apha.2024.10.001_bib81","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.10.035","article-title":"Suppression of glutamate carboxypeptidase II ameliorates neuronal apoptosis from ischemic brain injury","volume":"25","author":"Zhang","year":"2016","journal-title":"Journal of Stroke and Cerebrovascular Diseases: The Official Journal of National Stroke Association"},{"key":"10.1016\/bs.apha.2024.10.001_bib82","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.nbd.2016.06.010","article-title":"Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal\/newborn rabbit brain","volume":"94","author":"Zhang","year":"2016","journal-title":"Neurobiology of Disease"}],"container-title":["Advances in Pharmacology","Emerging Therapeutic Targets and Drug Delivery Approaches in IBD"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054358924000309?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054358924000309?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T17:55:57Z","timestamp":1753293357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054358924000309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9780443313585"],"references-count":82,"URL":"https:\/\/doi.org\/10.1016\/bs.apha.2024.10.001","relation":{},"ISSN":["1054-3589"],"issn-type":[{"value":"1054-3589","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}