{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T17:20:17Z","timestamp":1783099217667,"version":"3.54.6"},"reference-count":84,"publisher":"Elsevier","isbn-type":[{"value":"9780443342929","type":"print"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001631","name":"University College Dublin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001631","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/bs.apha.2024.10.006","type":"book-chapter","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T23:06:22Z","timestamp":1729292782000},"page":"211-235","source":"Crossref","is-referenced-by-count":1,"title":["Modulatory and protective effects of prolyl hydroxylase domain inhibitors in the central nervous system"],"prefix":"10.1016","author":[{"given":"Konstantinos","family":"Matheoudakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"O\u2019Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/bs.apha.2024.10.006_bib1","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1038\/s41380-022-01676-7","article-title":"Hypoxia Inducible Factor-1\u03b1 binds and activates \u03b3-secretase for A\u03b2 production under hypoxia and cerebral hypoperfusion","volume":"27","author":"Alexander","year":"2022","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/bs.apha.2024.10.006_bib2","doi-asserted-by":"crossref","DOI":"10.1007\/s11910-023-01282-2","article-title":"Neuroinflammation in acute ischemic and hemorrhagic stroke","author":"Alsbrook","year":"2023","journal-title":"Current Neurology and Neuroscience Reports"},{"key":"10.1016\/bs.apha.2024.10.006_bib3","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1271118","article-title":"Acriflavine, a HIF-1 inhibitor, preserves vision in an experimental autoimmune encephalomyelitis model of optic neuritis","volume":"14","author":"Anders","year":"2023","journal-title":"Frontiers in Immunology"},{"issue":"37","key":"10.1016\/bs.apha.2024.10.006_bib4","doi-asserted-by":"crossref","first-page":"38458","DOI":"10.1074\/jbc.M406026200","article-title":"Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor","volume":"279","author":"Appelhoffl","year":"2004","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"10.1016\/bs.apha.2024.10.006_bib5","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.neuroscience.2010.03.011","article-title":"Hydroxylase inhibition reduces synaptic transmission and protects against a glutamate-induced ischemia in the CA1 region of the rat hippocampus","volume":"167","author":"Batti","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/bs.apha.2024.10.006_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101343","article-title":"Hypoxia and brain aging: Neurodegeneration or neuroprotection?","author":"Burtscher","year":"2021","journal-title":"Ageing Research Reviews"},{"issue":"3","key":"10.1016\/bs.apha.2024.10.006_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.101721","article-title":"Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation","volume":"298","author":"Byts","year":"2022","journal-title":"Journal of Biological Chemistry"},{"issue":"40","key":"10.1016\/bs.apha.2024.10.006_bib8","doi-asserted-by":"crossref","first-page":"15370","DOI":"10.1074\/jbc.RA118.003004","article-title":"Deletion of the fih gene encoding an inhibitor of hypoxia-inducible factors increases hypoxia tolerance in zebrafish","volume":"293","author":"Cai","year":"2018","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2024.10.006_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.nlm.2018.12.002","article-title":"Genetic inactivation of hypoxia inducible factor 1-alpha (HIF-1\u03b1) in adult hippocampal progenitors impairs neurogenesis and pattern discrimination learning","volume":"157","author":"Carrica","year":"2019","journal-title":"Neurobiology of Learning and Memory"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.006_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/jnc.12804","article-title":"HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice","volume":"131","author":"Chen","year":"2014","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/bs.apha.2024.10.006_bib11","doi-asserted-by":"crossref","DOI":"10.1111\/apha.12117","article-title":"Hypoxia-inducible factor signalling mechanisms in the central nervous system","author":"Corcoran","year":"2013","journal-title":"Acta Physiologica"},{"issue":"10","key":"10.1016\/bs.apha.2024.10.006_bib12","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1002\/hipo.22142","article-title":"A role for prolyl hydroxylase domain proteins in hippocampal synaptic plasticity","volume":"23","author":"Corcoran","year":"2013","journal-title":"Hippocampus"},{"issue":"9","key":"10.1016\/bs.apha.2024.10.006_bib13","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1002\/glia.24019","article-title":"Treatment with hypoxia-mimetics protects cultured rat Schwann cells against oxidative stress-induced cell death","volume":"69","author":"David","year":"2021","journal-title":"Glia"},{"issue":"3","key":"10.1016\/bs.apha.2024.10.006_bib14","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/glia.24302","article-title":"Temporary induction of hypoxic adaptations by preconditioning fails to enhance Schwann cell transplant survival after spinal cord injury","volume":"71","author":"David","year":"2023","journal-title":"Glia"},{"key":"10.1016\/bs.apha.2024.10.006_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.physbeh.2018.11.034","article-title":"Dimethyloxalylglycine preconditioning enhances protective effects of bone marrow-derived mesenchymal stem cells in A\u03b2- induced Alzheimer disease","volume":"199","author":"Esmaeilzade","year":"2019","journal-title":"Physiology and Behavior"},{"key":"10.1016\/bs.apha.2024.10.006_bib16","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neulet.2014.07.014","article-title":"Neuroprotection by Orexin-A via HIF-1\u03b1 induction in a cellular model of Parkinson\u2019s disease","volume":"579","author":"Feng","year":"2014","journal-title":"Neuroscience Letters"},{"issue":"13","key":"10.1016\/bs.apha.2024.10.006_bib17","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1002\/cmdc.202100133","article-title":"Structural basis of prolyl hydroxylase domain inhibition by molidustat","volume":"16","author":"Figg","year":"2021","journal-title":"ChemMedChem"},{"issue":"3","key":"10.1016\/bs.apha.2024.10.006_bib18","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.bbrc.2016.04.085","article-title":"Prolyl hydroxylase-1 regulates hepatocyte apoptosis in an NF-\u03baB-dependent manner","volume":"474","author":"Fitzpatrick","year":"2016","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/bs.apha.2024.10.006_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/cdd.2008.10","article-title":"Role and regulation of prolyl hydroxylase domain proteins","author":"Fong","year":"2008","journal-title":"Cell Death and Differentiation"},{"issue":"1","key":"10.1016\/bs.apha.2024.10.006_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-42903-7","article-title":"The neuroprotective effects of FG-4592, a hypoxia-inducible factor-prolyl hydroxylase inhibitor, against oxidative stress induced by alpha-synuclein in N2a cells","volume":"13","author":"Fujimaki","year":"2023","journal-title":"Scientific Reports"},{"key":"10.1016\/bs.apha.2024.10.006_bib21","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.expneurol.2016.10.001","article-title":"Neuronal prolyl-4-hydroxylase 2 deficiency improves cognitive abilities in a murine model of cerebral hypoperfusion","volume":"286","author":"Gruneberg","year":"2016","journal-title":"Experimental Neurology"},{"key":"10.1016\/bs.apha.2024.10.006_bib22","article-title":"Hypoxia and alpha-synuclein: Inextricable link underlying the pathologic progression of Parkinson\u2019s disease","author":"Guo","year":"2022","journal-title":"Frontiers in Aging Neuroscience"},{"key":"10.1016\/bs.apha.2024.10.006_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1249492","article-title":"Daprodustat: A potential game-changer in renal anemia therapy\u2014A perspective","volume":"14","author":"Haider","year":"2023","journal-title":"Frontiers in Pharmacology"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.006_bib24","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/brain\/awaa427","article-title":"Hypoxia in multiple sclerosis; Is it the chicken or the egg?","volume":"144","author":"Halder","year":"2021","journal-title":"Brain"},{"key":"10.1016\/bs.apha.2024.10.006_bib25","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neures.2020.02.011","article-title":"6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis","volume":"163","author":"Hoshino","year":"2021","journal-title":"Neuroscience Research"},{"issue":"17","key":"10.1016\/bs.apha.2024.10.006_bib26","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1523\/JNEUROSCI.5493-09.2010","article-title":"Pharmacological and genetic accumulation of hypoxia-inducible factor-1\u03b1 enhances excitatory synaptic transmission in hippocampal neurons through the production of vascular endothelial growth factor","volume":"30","author":"Huang","year":"2010","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/bs.apha.2024.10.006_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.145146","article-title":"The role of hypoxia on Alzheimer\u2019s disease-related APP and Tau mRNA formation","volume":"766","author":"Jakubauskien\u0117","year":"2021","journal-title":"Gene"},{"key":"10.1016\/bs.apha.2024.10.006_bib28","doi-asserted-by":"crossref","DOI":"10.1007\/s12640-017-9766-1","article-title":"Huntington\u2019s disease and mitochondria","author":"Jodeiri Farshbaf","year":"2017","journal-title":"Neurotoxicity Research"},{"key":"10.1016\/bs.apha.2024.10.006_bib29","doi-asserted-by":"crossref","DOI":"10.1113\/JP278701","article-title":"AMPA receptor structure and auxiliary subunits","author":"Kamalova","year":"2021","journal-title":"Journal of Physiology"},{"key":"10.1016\/bs.apha.2024.10.006_bib30","doi-asserted-by":"crossref","DOI":"10.4196\/kjpp.2013.17.2.111","article-title":"Prolyl 4 hydroxylase: A critical target in the pathophysiology of diseases","author":"Kant","year":"2013","journal-title":"Korean Journal of Physiology and Pharmacology"},{"key":"10.1016\/bs.apha.2024.10.006_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/jcbfm.2012.28","article-title":"Hypoxia-inducible factor prolyl hydroxylase inhibition: Robust new target or another big bust for stroke therapeutics","author":"Karuppagounder","year":"2012","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.006_bib32","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1460-9568.2010.07339.x","article-title":"AMPA receptor trafficking and learning","volume":"32","author":"Keifer","year":"2010","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/bs.apha.2024.10.006_bib33","first-page":"655","article-title":"Novel anemia therapies in chronic kidney disease: Conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","author":"Ku","year":"2023"},{"key":"10.1016\/bs.apha.2024.10.006_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105200","article-title":"Brain-targeted hypoxia-inducible factor stabilization. Reduces neonatal hypoxic-ischemic brain injury","volume":"148","author":"Kuan","year":"2021","journal-title":"Neurobiology of Disease"},{"issue":"11","key":"10.1016\/bs.apha.2024.10.006_bib35","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1096\/fj.09-130047","article-title":"Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis","volume":"23","author":"Kupershmidt","year":"2009","journal-title":"FASEB Journal"},{"key":"10.1016\/bs.apha.2024.10.006_bib36","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuroscience.2017.11.011","article-title":"The hypoxia mimetic protocatechuic acid ethyl ester inhibits synaptic signaling and plasticity in the rat hippocampus","volume":"369","author":"Lanigan","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/bs.apha.2024.10.006_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2018.12.021","article-title":"Prolyl hydroxylase domain inhibitors: Can multiple mechanisms be an opportunity for ischemic stroke?","author":"Lanigan","year":"2019","journal-title":"Neuropharmacology"},{"issue":"42","key":"10.1016\/bs.apha.2024.10.006_bib38","doi-asserted-by":"crossref","first-page":"29065","DOI":"10.1074\/jbc.M109.000638","article-title":"Inhibition of prolyl hydroxylase protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Model for the potential involvement of the hypoxia-unducible factor pathway in Parkinson disease","volume":"284","author":"Lee","year":"2009","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/bs.apha.2024.10.006_bib39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2147\/HP.S173589","article-title":"Astrocyte HIF-2\u03b1 supports learning in a passive avoidance paradigm under hypoxic stress","volume":"6","author":"Leiton","year":"2018","journal-title":"Hypoxia"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.006_bib40","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1007\/s13311-019-00807-3","article-title":"FG-4592 improves depressive-like behaviors through HIF-1-mediated neurogenesis and synapse plasticity in rats","volume":"17","author":"Li","year":"2020","journal-title":"Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics"},{"key":"10.1016\/bs.apha.2024.10.006_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2019.101109","article-title":"HIF-1\u03b1 protects against oxidative stress by directly targeting mitochondria","volume":"25","author":"Li","year":"2019","journal-title":"Redox Biology"},{"key":"10.1016\/bs.apha.2024.10.006_bib42","article-title":"Roxadustat: Do we know all the answers?","author":"Li","year":"2023","journal-title":"Biomolecules and Biomedicine"},{"key":"10.1016\/bs.apha.2024.10.006_bib43","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.703084","article-title":"Hypoxia-inducible factor (HIF) in ischemic stroke and neurodegenerative disease","author":"Mitroshina","year":"2021","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10.1016\/bs.apha.2024.10.006_bib44","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25094581","article-title":"The role of oxygen homeostasis and the HIF-1 factor in the development of neurodegeneration","author":"Mitroshina","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.006_bib45","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.5","article-title":"Prolyl hydroxylase regulates axonal rewiring and motor recovery after traumatic brain injury","volume":"6","author":"Miyake","year":"2015","journal-title":"Cell Death and Disease"},{"key":"10.1016\/bs.apha.2024.10.006_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2023.110822","article-title":"The effects of prolyl hydroxylase inhibition during and post, hypoxia, oxygen glucose deprivation and oxidative stress, in isolated rat hippocampal slices","volume":"205","author":"Moreton","year":"2023","journal-title":"Brain Research Bulletin"},{"issue":"15","key":"10.1016\/bs.apha.2024.10.006_bib47","doi-asserted-by":"crossref","first-page":"13382","DOI":"10.1074\/jbc.M110.213785","article-title":"Iron mediates N-Methyl-D-aspartate receptor-dependent stimulation of calcium-induced pathways and hippocampal synaptic plasticity","volume":"286","author":"Mu\u00f1oz","year":"2011","journal-title":"Journal of Biological Chemistry"},{"issue":"5","key":"10.1016\/bs.apha.2024.10.006_bib48","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/bpa.12040","article-title":"Impaired cytoplasmic-nuclear transport of hypoxia-inducible factor-1\u03b1 in amyotrophic lateral sclerosis","volume":"23","author":"Nagara","year":"2013","journal-title":"Brain Pathology"},{"issue":"5","key":"10.1016\/bs.apha.2024.10.006_bib49","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/hipo.1069","article-title":"NMDA receptor regulation of memory and behavior in humans","volume":"11","author":"Newcomer","year":"2001","journal-title":"Hippocampus"},{"key":"10.1016\/bs.apha.2024.10.006_bib50","unstructured":"Niatsetskaya, Z., Basso, M., Speer, R. E., Mcconoughey, S. J., Coppola, G., Ma, T. C., & Ratan, R. R. (n.d.). HIF Prolyl Hydroxylase Inhibitors Prevent Neuronal Death Induced by Mitochondrial Toxins: Therapeutic Implications for Huntington\u2019s Disease and Alzheimer\u2019s Disease. Retrieved from www.liebertonline.com=ars."},{"key":"10.1016\/bs.apha.2024.10.006_bib51","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuroscience.2019.06.025","article-title":"Imaging hypoxic stress and the treatment of amyotrophic lateral sclerosis with dimethyloxalylglycine in a mice model","volume":"415","author":"Nomura","year":"2019","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.006_bib52","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.nbd.2011.10.020","article-title":"Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1\u03b1","volume":"45","author":"Ogle","year":"2012","journal-title":"Neurobiology of Disease"},{"issue":"8","key":"10.1016\/bs.apha.2024.10.006_bib53","doi-asserted-by":"crossref","DOI":"10.1007\/s00018-022-04460-6","article-title":"Activation of the hypoxia response protects mice from amyloid-\u03b2 accumulation","volume":"79","author":"Ollonen","year":"2022","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/bs.apha.2024.10.006_bib54","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroscience.2021.11.025","article-title":"Inhibition or deletion of hydroxylases-prolyl-4-hydroxyases 3 alleviates lipopolysaccharide-induced neuroinflammation and neurobehavioral deficiency","volume":"481","author":"Ou","year":"2022","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/bs.apha.2024.10.006_bib55","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/emboj.2011.499","article-title":"Hypoxia regulates glutamate receptor trafficking through an HIF-independent mechanism","volume":"31","author":"Park","year":"2012","journal-title":"EMBO Journal"},{"key":"10.1016\/bs.apha.2024.10.006_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2018.00361","article-title":"AMPA receptor trafficking for postsynaptic potentiation","author":"Park","year":"2018","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"3","key":"10.1016\/bs.apha.2024.10.006_bib57","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1007\/s13311-021-01089-4","article-title":"Betulinic acid hydroxamate is neuroprotective and induces protein phosphatase 2A-dependent HIF-1\u03b1 stabilization and post-transcriptional dephosphorylation of prolyl hydrolase 2","volume":"18","author":"Prados","year":"2021","journal-title":"Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics"},{"key":"10.1016\/bs.apha.2024.10.006_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.dscb.2022.100030","article-title":"Neuroprotective strategies for acute ischemic stroke: Targeting oxidative stress and prolyl hydroxylase domain inhibition in synaptic signalling","author":"Puzio","year":"2022","journal-title":"Brain Disorders"},{"key":"10.1016\/bs.apha.2024.10.006_bib59","article-title":"Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions","author":"Qin","year":"2022","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"10.1016\/bs.apha.2024.10.006_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2021.116115","article-title":"Discovery of neuroprotective agents that inhibit human prolyl hydroxylase PHD2","volume":"38","author":"Richardson","year":"2021","journal-title":"Bioorganic and Medicinal Chemistry"},{"issue":"8","key":"10.1016\/bs.apha.2024.10.006_bib61","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.1002\/glia.24380","article-title":"HIF prolyl hydroxylase 2\/3 deletion disrupts astrocytic integrity and exacerbates neuroinflammation","volume":"71","author":"Rosiewicz","year":"2023","journal-title":"Glia"},{"key":"10.1016\/bs.apha.2024.10.006_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116342","article-title":"Prolyl hydroxylase inhibitor FG-4592 alleviates neuroinflammation via HIF-1\/BNIP3 signaling in microglia","volume":"173","author":"Ruan","year":"2024","journal-title":"Biomedicine and Pharmacotherapy"},{"key":"10.1016\/bs.apha.2024.10.006_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113890","article-title":"Acute intermittent hypoxia and respiratory muscle recruitment in people with amyotrophic lateral sclerosis: A preliminary study","author":"Sajjadi","year":"2022","journal-title":"Experimental Neurology"},{"issue":"11","key":"10.1016\/bs.apha.2024.10.006_bib64","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1016\/j.celrep.2016.02.047","article-title":"The oxygen sensor PHD2 controls dendritic spines and synapses via modification of filamin A","volume":"14","author":"Segura","year":"2016","journal-title":"Cell Reports"},{"issue":"5","key":"10.1016\/bs.apha.2024.10.006_bib65","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0233261","article-title":"Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice","volume":"15","author":"Settelmeier","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/bs.apha.2024.10.006_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.977391","article-title":"The origin and distribution of the main oxygen sensing mechanism across metazoans","volume":"13","author":"Song","year":"2022","journal-title":"Frontiers in Physiology"},{"key":"10.1016\/bs.apha.2024.10.006_bib67","doi-asserted-by":"crossref","DOI":"10.25122\/jml-2021-0361","article-title":"The economic burden of stroke: A systematic review of cost of illness studies","author":"Strilciuc","year":"2021","journal-title":"Journal of Medicine and Life"},{"key":"10.1016\/bs.apha.2024.10.006_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108272","article-title":"Future perspectives of anemia management in chronic kidney disease using hypoxia-inducible factor-prolyl hydroxylase inhibitors","author":"Sugahara","year":"2022","journal-title":"Pharmacology and Therapeutics"},{"issue":"2","key":"10.1016\/bs.apha.2024.10.006_bib69","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/0271678X15606722","article-title":"The transient intraluminal filament middle cerebral artery occlusion model as a model of endovascular thrombectomy in stroke","volume":"36","author":"Sutherland","year":"2016","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"issue":"3","key":"10.1016\/bs.apha.2024.10.006_bib70","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s11064-017-2425-3","article-title":"The AMPA receptor subunit gluA1 is required for CA1 hippocampal long-term potentiation but is not essential for synaptic transmission","volume":"44","author":"Terashima","year":"2019","journal-title":"Neurochemical Research"},{"issue":"9","key":"10.1016\/bs.apha.2024.10.006_bib71","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/abbs\/gmx082","article-title":"Neuroprotective effect of deferoxamine on N-methyl-d-aspartate-induced excitotoxicity in RGC-5 cells","volume":"49","author":"Tian","year":"2017","journal-title":"Acta Biochimica et Biophysica Sinica"},{"key":"10.1016\/bs.apha.2024.10.006_bib72","doi-asserted-by":"crossref","DOI":"10.7759\/cureus.57990","article-title":"Ischemic stroke during daprodustat therapy for renal anemia: A report of three cases","author":"Uchio","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/bs.apha.2024.10.006_bib73","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.nbd.2013.08.016","article-title":"Effects of prolyl-hydroxylase inhibition and chronic intermittent hypoxia on synaptic transmission and plasticity in the rat CA1 and dentate gyrus","volume":"62","author":"Wall","year":"2014","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/bs.apha.2024.10.006_bib74","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jss.2019.09.023","article-title":"HIF-1\u03b1 and VEGF are involved in deferoxamine-ameliorated traumatic brain injury","volume":"246","author":"Wang","year":"2020","journal-title":"Journal of Surgical Research"},{"key":"10.1016\/bs.apha.2024.10.006_bib75","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0249591","article-title":"Hypoxia-inducible factor prolyl hydroxylase domain (PHD) inhibition after contusive spinal cord injury does not improve locomotor recovery","volume":"16","author":"Wei","year":"2021","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/bs.apha.2024.10.006_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076670","article-title":"Fumaric acid esters stimulate astrocytic VEGF expression through HIF-1\u03b1 and Nrf2","volume":"8","author":"Wiesner","year":"2013","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/bs.apha.2024.10.006_bib77","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1002\/jnr.21988","article-title":"HIF prolyl hydroxylase inhibition augments dopamine release in the rat brain in vivo","volume":"87","author":"Witten","year":"2009","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/bs.apha.2024.10.006_bib78","doi-asserted-by":"crossref","DOI":"10.1016\/j.tibs.2012.10.004","article-title":"Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes","author":"Wong","year":"2013","journal-title":"Trends in Biochemical Sciences"},{"key":"10.1016\/bs.apha.2024.10.006_bib79","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.brainres.2015.12.017","article-title":"Stabilization of HIF-1\u03b1 by FG-4592 promotes functional recovery and neural protection in experimental spinal cord injury","volume":"1632","author":"Wu","year":"2016","journal-title":"Brain Research"},{"key":"10.1016\/bs.apha.2024.10.006_bib80","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jmedchem.1c00415","article-title":"Inhibition of the oxygen-sensing asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor: A potential hypoxia response modulating strategy","author":"Wu","year":"2021","journal-title":"Journal of Medicinal Chemistry"},{"issue":"1","key":"10.1016\/bs.apha.2024.10.006_bib81","doi-asserted-by":"crossref","DOI":"10.1515\/tnsci-2022-0272","article-title":"HIF-1\u03b1 participates in secondary brain injury through regulating neuroinflammation","volume":"14","author":"Xu","year":"2023","journal-title":"Translational Neuroscience"},{"key":"10.1016\/bs.apha.2024.10.006_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2021.101994","article-title":"HIF-1\u03b1 aggravated traumatic brain injury by NLRP3 inflammasome-mediated pyroptosis and activation of microglia","volume":"116","author":"Yuan","year":"2021","journal-title":"Journal of Chemical Neuroanatomy"},{"issue":"6","key":"10.1016\/bs.apha.2024.10.006_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms22062849","article-title":"Prolyl hydroxylase 3 knockdown accelerates VHL-mutant kidney cancer growth in vivo","volume":"22","author":"Zacharias","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"issue":"9","key":"10.1016\/bs.apha.2024.10.006_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184049","article-title":"The prolyl 4-hydroxylase inhibitor GSK360A decreases post-stroke brain injury and sensory, motor, and cognitive behavioral deficits","volume":"12","author":"Zhou","year":"2017","journal-title":"PLoS One"}],"container-title":["Advances in Pharmacology","Targeting Enzymes in the Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054358924000358?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054358924000358?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T11:48:22Z","timestamp":1739015302000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054358924000358"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9780443342929"],"references-count":84,"URL":"https:\/\/doi.org\/10.1016\/bs.apha.2024.10.006","relation":{},"ISSN":["1054-3589"],"issn-type":[{"value":"1054-3589","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}