{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T20:29:15Z","timestamp":1783542555433,"version":"3.55.0"},"reference-count":158,"publisher":"Elsevier","isbn-type":[{"value":"9780443470387","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009553","name":"Agentura Pro Zdravotnick\u00fd V\u00fdzkum \u010cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["NW24\\u201303\\u221200079"],"award-info":[{"award-number":["NW24\\u201303\\u221200079"]}],"id":[{"id":"10.13039\/501100009553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.apha.2026.05.006","type":"book-chapter","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:28:27Z","timestamp":1779362907000},"page":"65-99","source":"Crossref","is-referenced-by-count":0,"title":["T Cell subsets for therapy\u2013unconventional CD1d-restricted natural killer T cells"],"prefix":"10.1016","author":[{"given":"Monika","family":"Holubov\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina Sofia","family":"Caputo Galarce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslava","family":"\u010ced\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.apha.2026.05.006_bib1","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.3389\/fimmu.2018.01052","article-title":"Critical contribution of NK group 2 member D expressed on invariant natural killer T cells in concanavalin a-induced liver hepatitis in mice","volume":"9","author":"Al Dulaimi","year":"2018","journal-title":"Frontiers in Immunology"},{"issue":"8","key":"10.1016\/bs.apha.2026.05.006_bib2","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.4049\/jimmunol.179.8.5126","article-title":"Cross-regulation between type I and type II NKT cells in regulating tumor immunity: A new immunoregulatory axis","volume":"179","author":"Ambrosino","year":"2007","journal-title":"Journal of Immunology"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib3","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1084\/jem.20040704","article-title":"A subset of liver NK T cells is activated during Leishmania donovani infection by CD1d-bound lipophosphoglycan","volume":"200","author":"Amprey","year":"2004","journal-title":"The Journal of Experimental Medicine"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib4","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1111\/cas.14428","article-title":"Activated invariant natural killer T cells directly recognize leukemia cells in a CD1d-independent manner","volume":"111","author":"Aoki","year":"2020","journal-title":"Cancer Science"},{"issue":"24","key":"10.1016\/bs.apha.2026.05.006_bib5","doi-asserted-by":"crossref","first-page":"10984","DOI":"10.1073\/pnas.1000576107","article-title":"Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a beta-linked self-glycolipid","volume":"107","author":"Arrenberg","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"18","key":"10.1016\/bs.apha.2026.05.006_bib6","doi-asserted-by":"crossref","first-page":"5315","DOI":"10.1158\/0008-5472.CAN-18-0734","article-title":"Activation of NKT cells in an Anti-PD-1-resistant tumor model enhances antitumor immunity by reinvigorating exhausted CD8 T cells","volume":"78","author":"Bae","year":"2018","journal-title":"Cancer Research"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib7","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.4049\/jimmunol.1102414","article-title":"Distinct APCs explain the cytokine bias of \u03b1-galactosylceramide variants in vivo","volume":"188","author":"Bai","year":"2012","journal-title":"Journal of Immunology"},{"issue":"10","key":"10.1016\/bs.apha.2026.05.006_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108116","article-title":"High dimensional single-cell analysis reveals iNKT cell developmental trajectories and effector fate decision","volume":"32","author":"Baranek","year":"2020","journal-title":"Cell Reports"},{"issue":"4","key":"10.1016\/bs.apha.2026.05.006_bib9","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S1074-7613(02)00305-9","article-title":"Activation of a nonclassical NKT cell subset in a transgenic mouse model of hepatitis B virus infection","volume":"16","author":"Baron","year":"2002","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/bs.apha.2026.05.006_bib10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/iid3.79","article-title":"Reduced iNKT cells numbers in type 1 diabetes patients and their first-degree relatives","volume":"3","author":"Beristain-Covarrubias","year":"2015","journal-title":"Immunity, Inflammation and Disease"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib11","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1002\/eji.200425958","article-title":"Limited correlation between human thymus and blood NKT cell content revealed by an ontogeny study of paired tissue samples","volume":"35","author":"Berzins","year":"2005","journal-title":"European Journal of Immunology"},{"key":"10.1016\/bs.apha.2026.05.006_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.998378","article-title":"Harnessing invariant natural killer T cells to control pathological inflammation","volume":"13","author":"Bharadwaj","year":"2022","journal-title":"Frontiers in Immunology"},{"issue":"8","key":"10.1016\/bs.apha.2026.05.006_bib13","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.4049\/jimmunol.147.8.2518","article-title":"Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells","volume":"147","author":"Blumberg","year":"1991","journal-title":"Journal of Immunology"},{"issue":"12","key":"10.1016\/bs.apha.2026.05.006_bib14","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/ni.2143","article-title":"Invariant natural killer T cells recognize lipid self antigen induced by microbial danger signals","volume":"12","author":"Brennan","year":"2011","journal-title":"Nature Immunology"},{"issue":"4","key":"10.1016\/bs.apha.2026.05.006_bib15","first-page":"561","article-title":"Tissue distribution of the non-polymorphic major histocompatibility complex class I-like molecule, CD1d","volume":"80","author":"Canchis","year":"1993","journal-title":"Immunology"},{"issue":"11","key":"10.1016\/bs.apha.2026.05.006_bib16","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2018.1470735","article-title":"Human CD4- invariant NKT lymphocytes regulate graft versus host disease","volume":"7","author":"Coman","year":"2018","journal-title":"Oncoimmunology"},{"issue":"11","key":"10.1016\/bs.apha.2026.05.006_bib17","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1016\/j.celrep.2018.02.058","article-title":"Bimodal CD40\/Fas-dependent crosstalk between iNKT cells and tumor-associated macrophages impairs prostate cancer progression","volume":"22","author":"Cortesi","year":"2018","journal-title":"Cell Reports"},{"issue":"2","key":"10.1016\/bs.apha.2026.05.006_bib18","article-title":"553 A phase I clinical trial of allogeneic NKT cells expressing a CD19-specific CAR in patients with relapsed or refractory B cell malignancies: An interim analysis","volume":"13","author":"Courtney","year":"2025","journal-title":"Journal for ImmunoTherapy of Cancer"},{"issue":"9","key":"10.1016\/bs.apha.2026.05.006_bib19","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1084\/jem.20050953","article-title":"Differential antitumor immunity mediated by NKT cell subsets in vivo","volume":"202","author":"Crowe","year":"2005","journal-title":"The Journal of Experimental Medicine"},{"issue":"8","key":"10.1016\/bs.apha.2026.05.006_bib20","doi-asserted-by":"crossref","first-page":"4020","DOI":"10.4049\/jimmunol.171.8.4020","article-title":"Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells","volume":"171","author":"Crowe","year":"2003","journal-title":"Journal of Immunology"},{"key":"10.1016\/bs.apha.2026.05.006_bib21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3389\/fimmu.2016.00555","article-title":"iNKT cells in secondary progressive multiple sclerosis patients display pro-inflammatory profiles","volume":"7","author":"De Biasi","year":"2016","journal-title":"Frontiers in Immunology"},{"issue":"12","key":"10.1016\/bs.apha.2026.05.006_bib22","doi-asserted-by":"crossref","first-page":"4036","DOI":"10.1172\/JCI36264","article-title":"Invariant NKT cells reduce the immunosuppressive activity of influenza A virus-induced myeloid-derived suppressor cells in mice and humans","volume":"118","author":"De Santo","year":"2008","journal-title":"The Journal of Clinical Investigation"},{"issue":"2","key":"10.1016\/bs.apha.2026.05.006_bib23","doi-asserted-by":"crossref","first-page":"723","DOI":"10.4049\/jimmunol.168.2.723","article-title":"Lipid protein interactions: The assembly of CD1d1 with cellular phospholipids occurs in the endoplasmic reticulum","volume":"168","author":"De Silva","year":"2002","journal-title":"Journal of Immunology"},{"issue":"8","key":"10.1016\/bs.apha.2026.05.006_bib24","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1002\/eji.201344399","article-title":"iNKT-cell help to B cells: A cooperative job between innate and adaptive immune responses","volume":"44","author":"Dellabona","year":"2014","journal-title":"European Journal of Immunology"},{"issue":"12","key":"10.1016\/bs.apha.2026.05.006_bib25","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1084\/jem.20021650","article-title":"A reversible defect in natural killer T cell function characterizes the progression of premalignant to malignant multiple myeloma","volume":"197","author":"Dhodapkar","year":"2003","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/bs.apha.2026.05.006_bib26","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1476-4598-8-116","article-title":"Identification of iGb3 and iGb4 in melanoma B16F10-Nex2 cells and the iNKT cell-mediated antitumor effect of dendritic cells primed with iGb3","volume":"8","author":"Dias","year":"2009","journal-title":"Molecular Cancer"},{"key":"10.1016\/bs.apha.2026.05.006_bib27","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.3389\/fimmu.2018.01360","article-title":"Activation and regulation of B cell responses by invariant natural killer T cells","volume":"9","author":"Doherty","year":"2018","journal-title":"Frontiers in Immunology"},{"issue":"23","key":"10.1016\/bs.apha.2026.05.006_bib28","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1182\/blood-2016-11-752444","article-title":"Invariant natural killer T cells ameliorate murine chronic GVHD by expanding donor regulatory T cells","volume":"129","author":"Du","year":"2017","journal-title":"Blood"},{"issue":"14","key":"10.1016\/bs.apha.2026.05.006_bib29","doi-asserted-by":"crossref","first-page":"3510","DOI":"10.1158\/1078-0432.CCR-16-0600","article-title":"Adoptive transfer of invariant NKT cells as immunotherapy for advanced melanoma: A phase I clinical trial","volume":"23","author":"Exley","year":"2017","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"10","key":"10.1016\/bs.apha.2026.05.006_bib30","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1172\/JCI19836","article-title":"Nonclassical CD1d-restricted NK T cells that produce IL-13 characterize an atypical Th2 response in ulcerative colitis","volume":"113","author":"Fuss","year":"2004","journal-title":"The Journal of Clinical Investigation"},{"issue":"4","key":"10.1016\/bs.apha.2026.05.006_bib31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/1074-7613(95)90175-2","article-title":"Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset","volume":"3","author":"Galy","year":"1995","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/bs.apha.2026.05.006_bib32","first-page":"3702","article-title":"A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors","volume":"8","author":"Giaccone","year":"2002","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib33","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1084\/jem.20011889","article-title":"Natural killer T cell ligand alpha-galactosylceramide enhances protective immunity induced by malaria vaccines","volume":"195","author":"Gonzalez-Aseguinolaza","year":"2002","journal-title":"The Journal of Experimental Medicine"},{"issue":"1","key":"10.1016\/bs.apha.2026.05.006_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111050","article-title":"A single-cell analysis of thymopoiesis and thymic iNKT cell development in pigs","volume":"40","author":"Gu","year":"2022","journal-title":"Cell Reports"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib35","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/bmt.2015.335","article-title":"Invariant natural killer T cells in hematopoietic stem cell transplantation: Killer choice for natural suppression","volume":"51","author":"Guan","year":"2016","journal-title":"Bone Marrow Transplantation"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib36","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1084\/jem.20011786","article-title":"Functionally distinct subsets of CD1d-restricted natural killer T cells revealed by CD1d tetramer staining","volume":"195","author":"Gumperz","year":"2002","journal-title":"The Journal of Experimental Medicine"},{"issue":"8","key":"10.1016\/bs.apha.2026.05.006_bib37","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1172\/JCI31602","article-title":"Type II NKT cell-mediated anergy induction in type I NKT cells prevents inflammatory liver disease","volume":"117","author":"Halder","year":"2007","journal-title":"The Journal of Clinical Investigation"},{"issue":"9","key":"10.1016\/bs.apha.2026.05.006_bib38","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.4103\/1673-5374.366498","article-title":"Immunological role of sulfatide in the pathogenesis of multiple sclerosis","volume":"18","author":"Hamatani","year":"2023","journal-title":"Neural Regeneration Research"},{"issue":"1","key":"10.1016\/bs.apha.2026.05.006_bib39","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/s41467-024-44905-z","article-title":"A phase 1\/2 clinical trial of invariant natural killer T cell therapy in moderate-severe acute respiratory distress syndrome","volume":"15","author":"Hammond","year":"2024","journal-title":"Nature Communications"},{"issue":"1","key":"10.1016\/bs.apha.2026.05.006_bib40","doi-asserted-by":"crossref","first-page":"6238","DOI":"10.1038\/s41467-020-20073-8","article-title":"Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells","volume":"11","author":"Harsha Krovi","year":"2020","journal-title":"Nature Communications"},{"issue":"1","key":"10.1016\/bs.apha.2026.05.006_bib41","doi-asserted-by":"crossref","first-page":"551","DOI":"10.4049\/jimmunol.174.1.551","article-title":"Stimulation of host NKT cells by synthetic glycolipid regulates acute graft-versus-host disease by inducing Th2 polarization of donor T cells","volume":"174","author":"Hashimoto","year":"2005","journal-title":"Journal of Immunology"},{"issue":"16","key":"10.1016\/bs.apha.2026.05.006_bib42","doi-asserted-by":"crossref","first-page":"9464","DOI":"10.1073\/pnas.1630663100","article-title":"Alpha-galactosylceramide (KRN7000) suppression of chemical- and oncogene-dependent carcinogenesis","volume":"100","author":"Hayakawa","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"18","key":"10.1016\/bs.apha.2026.05.006_bib43","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1182\/blood-2013-11-541235","article-title":"Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy","volume":"124","author":"Heczey","year":"2014","journal-title":"Blood"},{"issue":"6","key":"10.1016\/bs.apha.2026.05.006_bib44","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1038\/s41591-023-02363-y","article-title":"Anti-GD2 CAR-NKT cells in relapsed or refractory neuroblastoma: updated phase 1 trial interim results","volume":"29","author":"Heczey","year":"2023","journal-title":"Nature Medicine"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib45","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.202000999","article-title":"iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts","volume":"4","author":"Hess","year":"2021","journal-title":"Life Science Alliance"},{"issue":"1","key":"10.1016\/bs.apha.2026.05.006_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2011.03463.x","article-title":"Control of early stages in invariant natural killer T-cell development","volume":"134","author":"Hu","year":"2011","journal-title":"Immunology"},{"issue":"21","key":"10.1016\/bs.apha.2026.05.006_bib47","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1182\/blood-2011-11-389304","article-title":"Graft invariant natural killer T-cell dose predicts risk of acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation","volume":"119","author":"Chaidos","year":"2012","journal-title":"Blood"},{"issue":"9","key":"10.1016\/bs.apha.2026.05.006_bib48","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1084\/jem.20042592","article-title":"Sustained expansion of NKT cells and antigen-specific T cells after injection of alpha-galactosyl-ceramide loaded mature dendritic cells in cancer patients","volume":"201","author":"Chang","year":"2005","journal-title":"The Journal of Experimental Medicine"},{"issue":"2","key":"10.1016\/bs.apha.2026.05.006_bib49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1158\/2326-6066.CIR-25-0349","article-title":"The allogeneic FAP-CAR-IL15 iNKT therapy MiNK-215 remodels the tumor stroma to enhance antitumor immunity","volume":"14","author":"Chantzoura","year":"2026","journal-title":"Cancer Immunology Research"},{"issue":"10","key":"10.1016\/bs.apha.2026.05.006_bib50","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.4049\/jimmunol.1401805","article-title":"Role and regulation of CD1d in normal and pathological B cells","volume":"193","author":"Chaudhry","year":"2014","journal-title":"Journal of Immunology"},{"issue":"2, Supplement","key":"10.1016\/bs.apha.2026.05.006_bib51","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1016\/j.jtct.2023.12.058","article-title":"RGI-2001 with CNI-based prophylaxis demonstrates better acute Gvhd-free survival following myeloablative allohct without increased relapse: Comparison of a multi-center phase 2b study with a contemporaneous CIBMTR cohort","volume":"30","author":"Chen","year":"2024","journal-title":"Transplantation and Cellular Therapy"},{"key":"10.1016\/bs.apha.2026.05.006_bib52","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/206731","article-title":"Immunoregulation of NKT cells in systemic lupus erythematosus","volume":"2015","author":"Chen","year":"2015","journal-title":"Journal of Immunology Research"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib53","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.chembiol.2018.06.008","article-title":"Dual modifications of \u03b1-galactosylceramide synergize to promote activation of human invariant natural killer T cells and stimulate anti-tumor immunity","volume":"25","author":"Chennamadhavuni","year":"2018","journal-title":"Cell Chemical Biology"},{"issue":"6","key":"10.1016\/bs.apha.2026.05.006_bib54","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1093\/rheumatology\/keq457","article-title":"Numerical and functional deficiencies of natural killer T cells in systemic lupus erythematosus: their deficiency related to disease activity","volume":"50","author":"Cho","year":"2011","journal-title":"Rheumatology"},{"issue":"15","key":"10.1016\/bs.apha.2026.05.006_bib55","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1182\/blood-2013-01-480665","article-title":"Innate immune control of EBV-infected B cells by invariant natural killer T cells","volume":"122","author":"Chung","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1016\/bs.apha.2026.05.006_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-025-66801-w","article-title":"Allogeneic iPSC-derived iNKT cells in recurrent head and neck cancer: A phase 1 trial","volume":"16","author":"Iinuma","year":"2025","journal-title":"Nature Communications"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib57","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1158\/1078-0432.CCR-04-1453","article-title":"A phase I study of alpha-galactosylceramide (KRN7000)-pulsed dendritic cells in patients with advanced and recurrent non-small cell lung cancer","volume":"11","author":"Ishikawa","year":"2005","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"key":"10.1016\/bs.apha.2026.05.006_bib58","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.3389\/fimmu.2019.01068","article-title":"L-selectin: A major regulator of leukocyte adhesion, migration and signaling","volume":"10","author":"Ivetic","year":"2019","journal-title":"Frontiers in Immunology"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib59","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1084\/jem.20031389","article-title":"Prevention of autoimmunity by targeting a distinct, noninvariant CD1d-reactive T cell population reactive to sulfatide","volume":"199","author":"Jahng","year":"2004","journal-title":"The Journal of Experimental Medicine"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115587","article-title":"Single-cell transcriptomic profiling reveals diversity in human iNKT cells across hematologic tissues","volume":"44","author":"Jayasinghe","year":"2025","journal-title":"Cell Reports"},{"issue":"5356","key":"10.1016\/bs.apha.2026.05.006_bib61","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1126\/science.279.5356.1541","article-title":"Natural ligand of mouse CD1d1: Cellular glycosylphosphatidylinositol","volume":"279","author":"Joyce","year":"1998","journal-title":"Science (New York, N. Y.)"},{"issue":"2","key":"10.1016\/bs.apha.2026.05.006_bib62","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1128\/jb.176.2.284-290.1994","article-title":"The cell envelope structure of the lipopolysaccharide-lacking gram-negative bacterium Sphingomonas paucimobilis","volume":"176","author":"Kawasaki","year":"1994","journal-title":"Journal of Bacteriology"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib63","doi-asserted-by":"crossref","DOI":"10.1002\/cbic.202500979","article-title":"Development of a self-adjuvanting influenza peptide-glycolipid conjugate inducing CD8+ T-cell immunity","volume":"27","author":"Kikuchi","year":"2026","journal-title":"Chembiochem: A European Journal of Chemical Biology"},{"issue":"10","key":"10.1016\/bs.apha.2026.05.006_bib64","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/ni.2096","article-title":"Invariant natural killer T cells recognize glycolipids from pathogenic Gram-positive bacteria","volume":"12","author":"Kinjo","year":"2011","journal-title":"Nature Immunology"},{"issue":"9","key":"10.1016\/bs.apha.2026.05.006_bib65","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ni1380","article-title":"Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria","volume":"7","author":"Kinjo","year":"2006","journal-title":"Nature Immunology"},{"issue":"3","key":"10.1016\/bs.apha.2026.05.006_bib66","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1189\/jlb.1106654","article-title":"Reduced CD4+ subset and Th1 bias of the human iNKT cells in type 1 diabetes mellitus","volume":"81","author":"Kis","year":"2007","journal-title":"Journal of Leukocyte Biology"},{"issue":"2","key":"10.1016\/bs.apha.2026.05.006_bib67","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.stemcr.2016.01.005","article-title":"Cellular adjuvant properties, direct cytotoxicity of re-differentiated V\u03b124 invariant NKT-like cells from human induced pluripotent stem cells","volume":"6","author":"Kitayama","year":"2016","journal-title":"Stem Cell Reports"},{"issue":"4","key":"10.1016\/bs.apha.2026.05.006_bib68","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.4049\/jimmunol.0802430","article-title":"Immunosuppressive myeloid-derived suppressor cells can be converted into immunogenic APCs with the help of activated NKT cells: An alternative cell-based antitumor vaccine","volume":"182","author":"Ko","year":"2009","journal-title":"Journal of Immunology"},{"issue":"1","key":"10.1016\/bs.apha.2026.05.006_bib69","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/s12967-022-03442-3","article-title":"Exhaustion of CAR T cells: Potential causes and solutions","volume":"20","author":"Kouro","year":"2022","journal-title":"Journal of Translational Medicine"},{"key":"10.1016\/bs.apha.2026.05.006_bib70","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3389\/fimmu.2018.00367","article-title":"The role of natural killer T cells in cancer-a phenotypical and functional approach","volume":"9","author":"Krijgsman","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.apha.2026.05.006_bib71","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.3389\/fimmu.2018.01393","article-title":"Invariant natural killer T cell subsets-more than just developmental intermediates","volume":"9","author":"Krovi","year":"2018","journal-title":"Frontiers in Immunology"},{"issue":"4","key":"10.1016\/bs.apha.2026.05.006_bib72","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1128\/IAI.01334-12","article-title":"Sulfatide attenuates experimental Staphylococcus aureus sepsis through a CD1d-dependent pathway","volume":"81","author":"Kwiecinski","year":"2013","journal-title":"Infection and Immunity"},{"issue":"6","key":"10.1016\/bs.apha.2026.05.006_bib73","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1158\/2326-6066.CIR-18-0650","article-title":"NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion","volume":"7","author":"Lam","year":"2019","journal-title":"Cancer Immunology Research"},{"issue":"1","key":"10.1016\/bs.apha.2026.05.006_bib74","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41467-023-44310-y","article-title":"IL-12 reprograms CAR-expressing natural killer T cells to long-lived Th1-polarized cells with potent antitumor activity","volume":"15","author":"Landoni","year":"2024","journal-title":"Nature Communications"},{"key":"10.1016\/bs.apha.2026.05.006_bib75","article-title":"Use of a Clostridioides difficile murine immunization and challenge model to evaluate single and combination vaccine adjuvants consisting of alum and NKT cell-activating ligands","volume":"12","author":"Lang","year":"2021","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.apha.2026.05.006_bib76","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.molimm.2020.12.005","article-title":"Reading the room: iNKT cells influence B cell responses","volume":"130","author":"Leadbetter","year":"2021","journal-title":"Molecular Immunology"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib77","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1084\/jem.20011908","article-title":"Distinct functional lineages of human V(alpha)24 natural killer T cells","volume":"195","author":"Lee","year":"2002","journal-title":"The Journal of Experimental Medicine"},{"issue":"3","key":"10.1016\/bs.apha.2026.05.006_bib78","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.bbmt.2014.12.021","article-title":"CD161+ T cells as predictive markers for acute graft-versus-host disease","volume":"21","author":"Lee","year":"2015","journal-title":"Biology of Blood and Marrow Transplantation"},{"issue":"11","key":"10.1016\/bs.apha.2026.05.006_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/ni.2731","article-title":"Steady state production of IL-4 modulates immunity in different strains and is determined by lineage diversity of iNKT cells","volume":"14","author":"Lee","year":"2013","journal-title":"Nature Immunology"},{"issue":"3","key":"10.1016\/bs.apha.2026.05.006_bib80","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/imm.13288","article-title":"Hepatocyte CD1d protects against liver immunopathology in mice with schistosomiasis japonica","volume":"162","author":"Lei","year":"2021","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/bs.apha.2026.05.006_bib81","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1038\/s41467-025-56270-6","article-title":"Allogeneic CD33-directed CAR-NKT cells for the treatment of bone marrow-resident myeloid malignancies","volume":"16","author":"Li","year":"2025","journal-title":"Nature Communications"},{"issue":"1","key":"10.1016\/bs.apha.2026.05.006_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2025.104340","article-title":"Protocol to generate human stem cell-derived CD70-directed allogeneic CAR-NKT cells for treating renal cell carcinoma","volume":"7","author":"Li","year":"2026","journal-title":"STAR Protocols"},{"issue":"11","key":"10.1016\/bs.apha.2026.05.006_bib83","doi-asserted-by":"crossref","DOI":"10.1016\/j.xcrm.2021.100449","article-title":"Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy","volume":"2","author":"Li","year":"2021","journal-title":"Cell Reports. Medicine"},{"issue":"3","key":"10.1016\/bs.apha.2026.05.006_bib84","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/s41587-024-02226-y","article-title":"Generation of allogeneic CAR-NKT cells from hematopoietic stem and progenitor cells using a clinically guided culture method","volume":"43","author":"Li","year":"2025","journal-title":"Nature Biotechnology"},{"issue":"2","key":"10.1016\/bs.apha.2026.05.006_bib85","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1053\/j.gastro.2011.10.030","article-title":"Dysregulation of CD1d-restricted type ii natural killer T cells leads to spontaneous development of colitis in mice","volume":"142","author":"Liao","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.apha.2026.05.006_bib86","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2022.101342","article-title":"iNKT: A new avenue for CAR-based cancer immunotherapy","volume":"17","author":"Liu","year":"2022","journal-title":"Translational Oncology"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib87","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.3390\/biomedicines10071723","article-title":"Human iNKT cells modulate macrophage survival and phenotype","volume":"10","author":"Loureiro","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/bs.apha.2026.05.006_bib88","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1186\/s12879-014-0706-x","article-title":"Alpha-galactosylceramide enhances protective immunity induced by DNA vaccine of the SAG5D gene of toxoplasma gondii","volume":"14","author":"Lu","year":"2014","journal-title":"BMC Infectious Diseases"},{"issue":"10","key":"10.1016\/bs.apha.2026.05.006_bib89","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1182\/blood.2021010887","article-title":"Invariant natural killer T-cell subsets have diverse graft-versus-host-disease-preventing and antitumor effects","volume":"138","author":"Maas-Bauer","year":"2021","journal-title":"Blood"},{"issue":"14","key":"10.1016\/bs.apha.2026.05.006_bib90","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1182\/blood-2015-12-688739","article-title":"Larger number of invariant natural killer T cells in PBSC allografts correlates with improved GVHD-free and progression-free survival","volume":"127","author":"Malard","year":"2016","journal-title":"Blood"},{"issue":"3","key":"10.1016\/bs.apha.2026.05.006_bib91","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.4049\/jimmunol.1302898","article-title":"Dendritic cells and anergic type I NKT cells play a crucial role in sulfatide-mediated immune regulation in experimental autoimmune encephalomyelitis","volume":"193","author":"Maricic","year":"2014","journal-title":"Journal of Immunology"},{"key":"10.1016\/bs.apha.2026.05.006_bib92","doi-asserted-by":"crossref","first-page":"900","DOI":"10.3389\/fimmu.2017.00900","article-title":"Invariant natural killer T cells as suppressors of graft-versus-host disease in allogeneic hematopoietic stem cell transplantation","volume":"8","author":"Mavers","year":"2017","journal-title":"Frontiers in Immunology"},{"issue":"9","key":"10.1016\/bs.apha.2026.05.006_bib93","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.20031462","article-title":"Natural killer T cells infiltrate neuroblastomas expressing the chemokine CCL2","volume":"199","author":"Metelitsa","year":"2004","journal-title":"The Journal of Experimental Medicine"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib94","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1200\/JCO.2006.08.5787","article-title":"Low levels of circulating invariant natural killer T cells predict poor clinical outcome in patients with head and neck squamous cell carcinoma","volume":"25","author":"Molling","year":"2007","journal-title":"Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology"},{"issue":"12","key":"10.1016\/bs.apha.2026.05.006_bib95","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1021\/jm00012a018","article-title":"Structure-activity relationship of alpha-galactosylceramides against B16-bearing mice","volume":"38","author":"Morita","year":"1995","journal-title":"Journal of Medicinal Chemistry"},{"issue":"20 Pt 1","key":"10.1016\/bs.apha.2026.05.006_bib96","doi-asserted-by":"crossref","first-page":"6079","DOI":"10.1158\/1078-0432.CCR-06-0114","article-title":"A phase I study of in vitro expanded natural killer T cells in patients with advanced and recurrent non-small cell lung cancer","volume":"12","author":"Motohashi","year":"2006","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"2","key":"10.1016\/bs.apha.2026.05.006_bib97","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/ijc.10678","article-title":"Preserved IFN-alpha production of circulating Valpha24 NKT cells in primary lung cancer patients","volume":"102","author":"Motohashi","year":"2002","journal-title":"International Journal of Cancer"},{"issue":"2","key":"10.1016\/bs.apha.2026.05.006_bib98","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.clim.2011.01.009","article-title":"Anti-tumor immune responses induced by iNKT cell-based immunotherapy for lung cancer and head and neck cancer","volume":"140","author":"Motohashi","year":"2011","journal-title":"Clinical Immunology"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib99","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1084\/jem.20011712","article-title":"CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection","volume":"195","author":"Motsinger","year":"2002","journal-title":"The Journal of Experimental Medicine"},{"issue":"20","key":"10.1016\/bs.apha.2026.05.006_bib100","doi-asserted-by":"crossref","first-page":"5174","DOI":"10.3390\/cancers13205174","article-title":"The current landscape of NKT cell immunotherapy and the hills ahead","volume":"13","author":"Nelson","year":"2021","journal-title":"Cancers"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib101","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.4049\/jimmunol.1800429","article-title":"IL-21 Selectively protects CD62L+ NKT cells and enhances their effector functions for adoptive immunotherapy","volume":"201","author":"Ngai","year":"2018","journal-title":"Journal of Immunology"},{"issue":"15","key":"10.1016\/bs.apha.2026.05.006_bib102","doi-asserted-by":"crossref","first-page":"5140","DOI":"10.1158\/1078-0432.CCR-10-3105","article-title":"Comparison of clinical and immunological effects of intravenous and intradermal administration of \u03b1-galactosylceramide (KRN7000)-pulsed dendritic cells","volume":"17","author":"Nicol","year":"2011","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"2","key":"10.1016\/bs.apha.2026.05.006_bib103","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1182\/blood-2003-04-1155","article-title":"Therapeutic activation of Valpha24+Vbeta11+ NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity","volume":"103","author":"Nieda","year":"2004","journal-title":"Blood"},{"key":"10.1016\/bs.apha.2026.05.006_bib104","doi-asserted-by":"crossref","first-page":"548","DOI":"10.3389\/fimmu.2018.00548","article-title":"CD1d-Restricted type II NKT cells reactive with endogenous hydrophobic peptides","volume":"9","author":"Nishioka","year":"2018","journal-title":"Frontiers in Immunology"},{"issue":"1\u20132","key":"10.1016\/bs.apha.2026.05.006_bib105","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.cellimm.2012.06.004","article-title":"Innate-like behavior of human invariant natural killer T cells during herpes simplex virus infection","volume":"278","author":"Novakova","year":"2012","journal-title":"Cellular Immunology"},{"issue":"10","key":"10.1016\/bs.apha.2026.05.006_bib106","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.2337\/diacare.25.10.1818","article-title":"High frequency of valpha24(+) vbeta11(+) T-cells observed in type 1 diabetes","volume":"25","author":"Oikawa","year":"2002","journal-title":"Diabetes Care"},{"issue":"7501","key":"10.1016\/bs.apha.2026.05.006_bib107","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nature13150","article-title":"Protective mucosal immunity mediated by epithelial CD1d and IL-10","volume":"509","author":"Olszak","year":"2014","journal-title":"Nature"},{"issue":"20","key":"10.1016\/bs.apha.2026.05.006_bib108","doi-asserted-by":"crossref","first-page":"6009","DOI":"10.1182\/bloodadvances.2023010032","article-title":"Anti-myeloma efficacy of CAR-iNKT is enhanced with a long-acting IL-7, rhIL-7-hyFc","volume":"7","author":"O\u2019Neal","year":"2023","journal-title":"Blood Advances"},{"issue":"10","key":"10.1016\/bs.apha.2026.05.006_bib109","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0078407","article-title":"A glycolipid adjuvant, 7DW8-5, enhances CD8+ T cell responses induced by an adenovirus-vectored malaria vaccine in non-human primates","volume":"8","author":"Padte","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/bs.apha.2026.05.006_bib110","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.clim.2009.11.007","article-title":"Rituximab treatment overcomes reduction of regulatory iNKT cells in patients with rheumatoid arthritis","volume":"134","author":"Parietti","year":"2010","journal-title":"Clinical Immunology"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib111","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.4049\/jimmunol.181.5.3268","article-title":"Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer Ig receptors","volume":"181","author":"Patterson","year":"2008","journal-title":"Journal of Immunology"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib112","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1084\/jem.20011544","article-title":"A natural killer T (NKT) cell developmental pathway iInvolving a thymus-dependent NK1.1(-)CD4(+) CD1d-dependent precursor stage","volume":"195","author":"Pellicci","year":"2002","journal-title":"The Journal of Experimental Medicine"},{"issue":"18","key":"10.1016\/bs.apha.2026.05.006_bib113","doi-asserted-by":"crossref","first-page":"4458","DOI":"10.1182\/blood-2008-06-165506","article-title":"Host natural killer T cells induce an interleukin-4-dependent expansion of donor CD4+CD25+Foxp3+ T regulatory cells that protects against graft-versus-host disease","volume":"113","author":"Pillai","year":"2009","journal-title":"Blood"},{"issue":"3","key":"10.1016\/bs.apha.2026.05.006_bib114","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.3390\/ijms22031096","article-title":"Preclinical evaluation of invariant natural killer T cells modified with CD38 or BCMA chimeric antigen receptors for multiple myeloma","volume":"22","author":"Poels","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"10.1016\/bs.apha.2026.05.006_bib115","article-title":"400 Persistence and tissue distribution of agent-797 \u2013 a native allogeneic iNKT cell-therapy drug product","volume":"9","author":"Purbhoo","year":"2021","journal-title":"Journal for ImmunoTherapy of Cancer"},{"issue":"2","key":"10.1016\/bs.apha.2026.05.006_bib116","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1182\/blood.2025029302","article-title":"Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A-rearranged leukemia","volume":"147","author":"Ren","year":"2026","journal-title":"Blood"},{"issue":"1\u20132","key":"10.1016\/bs.apha.2026.05.006_bib117","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1615\/ForumImmunDisTher.2015014226","article-title":"Human T-cell development and thymic egress: An infectious disease perspective","volume":"6","author":"Resop","year":"2015","journal-title":"Forum on Immunopathological Diseases and Therapeutics"},{"issue":"3","key":"10.1016\/bs.apha.2026.05.006_bib118","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1182\/blood-2012-06-435503","article-title":"Clinical regressions and broad immune activation following combination therapy targeting human NKT cells in myeloma","volume":"121","author":"Richter","year":"2013","journal-title":"Blood"},{"issue":"4","key":"10.1016\/bs.apha.2026.05.006_bib119","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.humimm.2009.01.012","article-title":"Frequency and function of circulating invariant NKT cells in autoimmune diabetes mellitus and thyroid diseases in Colombian patients","volume":"70","author":"Roman-Gonzalez","year":"2009","journal-title":"Human Immunology"},{"issue":"4","key":"10.1016\/bs.apha.2026.05.006_bib120","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.ccell.2018.08.017","article-title":"Enhanced Anti-lymphoma activity of CAR19-iNKT cells underpinned by dual CD19 and CD1d targeting","volume":"34","author":"Rotolo","year":"2018","journal-title":"Cancer Cell"},{"issue":"10","key":"10.1016\/bs.apha.2026.05.006_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.xcrm.2023.101241","article-title":"Unedited allogeneic iNKT cells show extended persistence in MHC-mismatched canine recipients","volume":"4","author":"Rotolo","year":"2023","journal-title":"Cell Reports. Medicine"},{"issue":"10","key":"10.1016\/bs.apha.2026.05.006_bib122","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1182\/blood-2012-01-404673","article-title":"Early posttransplantation donor-derived invariant natural killer T-cell recovery predicts the occurrence of acute graft-versus-host disease and overall survival","volume":"120","author":"Rubio","year":"2012","journal-title":"Blood"},{"issue":"11","key":"10.1016\/bs.apha.2026.05.006_bib123","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1182\/blood.V106.11.5239.5239","article-title":"Expanded human NKT type II cells: Effective against colon cancer cells, safe across major MHC barriers and successfully expandable after non-myeloablative HCT for solid tumors","volume":"106","author":"Sangiolo","year":"2005","journal-title":"Blood"},{"issue":"16","key":"10.1016\/bs.apha.2026.05.006_bib124","doi-asserted-by":"crossref","first-page":"9054","DOI":"10.1073\/pnas.1920463117","article-title":"Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses","volume":"117","author":"Sedimbi","year":"2020","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/bs.apha.2026.05.006_bib125","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76659-1","article-title":"Unveiling the heterogeneity of NKT cells in the liver through single cell RNA sequencing","volume":"10","author":"Shen","year":"2020","journal-title":"Scientific Reports"},{"issue":"8","key":"10.1016\/bs.apha.2026.05.006_bib126","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.4049\/jimmunol.2001283","article-title":"Glycolipid-containing nanoparticle vaccine engages invariant NKT cells to enhance humoral protection against systemic bacterial infection but abrogates T-independent vaccine responses","volume":"206","author":"Shute","year":"2021","journal-title":"Journal of Immunology"},{"issue":"22","key":"10.1016\/bs.apha.2026.05.006_bib127","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1182\/blood-2014-11-612762","article-title":"Third-party CD4+ invariant natural killer T cells protect from murine GVHD lethality","volume":"125","author":"Schneidawind","year":"2015","journal-title":"Blood"},{"issue":"8","key":"10.1016\/bs.apha.2026.05.006_bib128","doi-asserted-by":"crossref","first-page":"513.e1","DOI":"10.1016\/j.jtct.2022.05.011","article-title":"Low graft invariant natural killer T-cell dose is a risk factor for cytomegalovirus reactivation after allogeneic hematopoietic cell transplantation","volume":"28","author":"Schneidawind","year":"2022","journal-title":"Transplantation and Cellular Therapy"},{"issue":"22","key":"10.1016\/bs.apha.2026.05.006_bib129","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1182\/blood-2014-05-576017","article-title":"CD4+ invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD4+CD25+FoxP3+ regulatory T cells","volume":"124","author":"Schneidawind","year":"2014","journal-title":"Blood"},{"issue":"2","key":"10.1016\/bs.apha.2026.05.006_bib130","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.clim.2010.11.010","article-title":"Clinical experience with \u03b1-galactosylceramide (KRN7000) in patients with advanced cancer and chronic hepatitis B\/C infection","volume":"140","author":"Schneiders","year":"2011","journal-title":"Clinical Immunology"},{"issue":"21","key":"10.1016\/bs.apha.2026.05.006_bib131","doi-asserted-by":"crossref","first-page":"6054","DOI":"10.1158\/1078-0432.CCR-21-1329","article-title":"Allogeneic CAR invariant natural killer T cells exert potent antitumor effects through host CD8 T-cell cross-priming","volume":"27","author":"Simonetta","year":"2021","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"3","key":"10.1016\/bs.apha.2026.05.006_bib132","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12794","article-title":"Defining a novel subset of CD1d-dependent type II natural killer T cells using natural killer cell-associated markers","volume":"90","author":"Singh","year":"2019","journal-title":"Scandinavian Journal of Immunology"},{"issue":"6","key":"10.1016\/bs.apha.2026.05.006_bib133","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1172\/JCI37869","article-title":"Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages","volume":"119","author":"Song","year":"2009","journal-title":"The Journal of Clinical Investigation"},{"issue":"3","key":"10.1016\/bs.apha.2026.05.006_bib134","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/apm.12140","article-title":"The preventive role of type 2 NKT cells in the development of type 1 diabetes","volume":"122","author":"S\u00f8rensen","year":"2014","journal-title":"APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037771","article-title":"NKT cells stimulated by long fatty acyl chain sulfatides significantly reduce the incidence of type 1 diabetes in nonobese diabetic mice [corrected]","volume":"7","author":"Subramanian","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/bs.apha.2026.05.006_bib136","first-page":"33","article-title":"Sulfatide administration leads to inhibition of HIV-1 replication and enhanced hematopoeisis","volume":"5","author":"Sundell","year":"2010","journal-title":"Journal of Stem Cells"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib137","doi-asserted-by":"crossref","first-page":"4046","DOI":"10.4049\/jimmunol.167.7.4046","article-title":"Loss of IFN-gamma production by invariant NK T cells in advanced cancer","volume":"167","author":"Tahir","year":"2001","journal-title":"Journal of Immunology"},{"issue":"20","key":"10.1016\/bs.apha.2026.05.006_bib138","doi-asserted-by":"crossref","first-page":"7322","DOI":"10.1158\/1078-0432.CCR-05-0877","article-title":"Increased intratumor Valpha24-positive natural killer T cells: a prognostic factor for primary colorectal carcinomas","volume":"11","author":"Tachibana","year":"2005","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib139","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1073\/pnas.1220601110","article-title":"Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs","volume":"110","author":"Tatituri","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"11","key":"10.1016\/bs.apha.2026.05.006_bib140","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1084\/jem.20022227","article-title":"Transforming growth factor-beta production and myeloid cells are an effector mechanism through which CD1d-restricted T cells block cytotoxic T lymphocyte-mediated tumor immunosurveillance: Abrogation prevents tumor recurrence","volume":"198","author":"Terabe","year":"2003","journal-title":"The Journal of Experimental Medicine"},{"issue":"12","key":"10.1016\/bs.apha.2026.05.006_bib141","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1084\/jem.20051381","article-title":"A nonclassical non-V\u03b114J\u03b118 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance","volume":"202","author":"Terabe","year":"2005","journal-title":"The Journal of Experimental Medicine"},{"issue":"6","key":"10.1016\/bs.apha.2026.05.006_bib142","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1172\/JCI83476","article-title":"CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo","volume":"126","author":"Tian","year":"2016","journal-title":"The Journal of Clinical Investigation"},{"issue":"3","key":"10.1016\/bs.apha.2026.05.006_bib143","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00262-007-0373-5","article-title":"Phase I study of alpha-galactosylceramide-pulsed antigen presenting cells administration to the nasal submucosa in unresectable or recurrent head and neck cancer","volume":"57","author":"Uchida","year":"2008","journal-title":"Cancer Immunology, Immunotherapy: CII"},{"issue":"3","key":"10.1016\/bs.apha.2026.05.006_bib144","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.4049\/jimmunol.168.3.1490","article-title":"Selective decrease in circulating V alpha 24+V beta 11+ NKT cells during HIV type 1 infection","volume":"168","author":"van der Vliet","year":"2002","journal-title":"Journal of Immunology"},{"key":"10.1016\/bs.apha.2026.05.006_bib145","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3389\/fimmu.2018.00519","article-title":"Therapeutic potential of invariant natural killer T cells in autoimmunity","volume":"9","author":"Van Kaer","year":"2018","journal-title":"Frontiers in Immunology"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib146","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.4049\/jimmunol.1300562","article-title":"Bacterial CD1d-restricted glycolipids induce IL-10 production by human regulatory T cells upon cross-talk with invariant NKT cells","volume":"191","author":"Venken","year":"2013","journal-title":"Journal of Immunology"},{"issue":"4","key":"10.1016\/bs.apha.2026.05.006_bib147","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1073\/pnas.0909479107","article-title":"Lipid binding orientation within CD1d affects recognition of Borrelia burgorferi antigens by NKT cells","volume":"107","author":"Wang","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib148","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41423-019-0243-z","article-title":"Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors","volume":"17","author":"Wang","year":"2020","journal-title":"Cellular & Molecular Immunology"},{"issue":"5","key":"10.1016\/bs.apha.2026.05.006_bib149","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/mi.2013.122","article-title":"IL-17-producing NKT cells depend exclusively on IL-7 for homeostasis and survival","volume":"7","author":"Webster","year":"2014","journal-title":"Mucosal Immunology"},{"issue":"Pt 3","key":"10.1016\/bs.apha.2026.05.006_bib150","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1111\/j.1365-2818.1990.tb02969.x","article-title":"Receptor autoradiography and 2-deoxyglucose techniques in neuroscience","volume":"157","author":"Wiederhold","year":"1990","journal-title":"Journal of Microscopy"},{"issue":"3","key":"10.1016\/bs.apha.2026.05.006_bib151","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.clim.2010.11.014","article-title":"Induction of NKT cell-specific immune responses in cancer tissues after NKT cell-targeted adoptive immunotherapy","volume":"138","author":"Yamasaki","year":"2011","journal-title":"Clinical Immunology"},{"issue":"12","key":"10.1016\/bs.apha.2026.05.006_bib152","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.4049\/jimmunol.168.12.6494","article-title":"Impaired proliferative response of V alpha 24 NKT cells from cancer patients against alpha-galactosylceramide","volume":"168","author":"Yanagisawa","year":"2002","journal-title":"Journal of Immunology"},{"key":"10.1016\/bs.apha.2026.05.006_bib153","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.898473","article-title":"Identification and isolation of type II NKT cell subsets in human blood and liver","volume":"13","author":"Yang Zhou","year":"2022","journal-title":"Frontiers in Immunology"},{"issue":"2","key":"10.1016\/bs.apha.2026.05.006_bib154","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.leukres.2004.06.005","article-title":"The peripheral blood Valpha24+ NKT cell numbers decrease in patients with haematopoietic malignancy","volume":"29","author":"Yoneda","year":"2005","journal-title":"Leukemia Research"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib155","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/nm.2811","article-title":"Hepatitis B virus-induced lipid alterations contribute to natural killer T cell-dependent protective immunity","volume":"18","author":"Zeissig","year":"2012","journal-title":"Nature Medicine"},{"key":"10.1016\/bs.apha.2026.05.006_bib156","article-title":"Mutation of the Traj18 gene segment using TALENs to generate Natural Killer T cell deficient mice","volume":"6","author":"Zhang","year":"2016","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/bs.apha.2026.05.006_bib157","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13045-022-01287-3","article-title":"Post-transplant cyclophosphamide alters immune signatures and leads to impaired T cell reconstitution in allogeneic hematopoietic stem cell transplant","volume":"15","author":"Zhao","year":"2022","journal-title":"Journal of Hematology & Oncology"},{"issue":"7","key":"10.1016\/bs.apha.2026.05.006_bib158","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1073\/pnas.1323845111","article-title":"Polyclonal type II natural killer T cells require PLZF and SAP for their development and contribute to CpG-mediated antitumor response","volume":"111","author":"Zhao","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"}],"container-title":["Advances in Pharmacology","Pharmacology of T-Cell Therapies"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054358926000359?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1054358926000359?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:54:23Z","timestamp":1783540463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1054358926000359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443470387"],"references-count":158,"URL":"https:\/\/doi.org\/10.1016\/bs.apha.2026.05.006","relation":{},"ISSN":["1054-3589"],"issn-type":[{"value":"1054-3589","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}