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Springer Berlin Heidelberg. \u3008https:\/\/doi.org\/10.1007\/8904_2011_32\u3009.","DOI":"10.1007\/8904_2011_32"},{"issue":"5","key":"10.1016\/bs.ctdb.2024.02.006_bib179","first-page":"1041","article-title":"Bachmann\u2019s bundle: A key player in the development of atrial fibrillation?","volume":"6","author":"Van Campenhout","year":"2013","journal-title":"Circulation: Arrhythmia and Electrophysiology"},{"issue":"3","key":"10.1016\/bs.ctdb.2024.02.006_bib180","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2019.07.004","article-title":"Gradual differentiation and confinement of the cardiac conduction system as indicated by marker gene expression","volume":"1867","author":"Van Eif","year":"2020","journal-title":"Biochimica et Biophysica Acta (BBA)\u2014Molecular Cell Research"},{"issue":"4","key":"10.1016\/bs.ctdb.2024.02.006_bib181","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1399-0004.2010.01512.x","article-title":"Desmin-related myopathy","volume":"80","author":"Van Spaendonck-Zwarts","year":"2011","journal-title":"Clinical Genetics"},{"issue":"2","key":"10.1016\/bs.ctdb.2024.02.006_bib182","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1242\/dev.124883","article-title":"The formation and function of the cardiac conduction system","volume":"143","author":"van Weerd","year":"2016","journal-title":"Development (Cambridge, England)"},{"issue":"5","key":"10.1016\/bs.ctdb.2024.02.006_bib183","first-page":"H619","article-title":"Mechanisms of cardiac conduction: A history of revisions","volume":"306","author":"Veeraraghavan","year":"2014","journal-title":"American Journal of"},{"issue":"4","key":"10.1016\/bs.ctdb.2024.02.006_bib184","doi-asserted-by":"crossref","DOI":"10.1161\/01.RES.0000031164.28289.55","article-title":"Novel perspectives on the beating rate of the heart","volume":"91","author":"Vinogradova","year":"2002","journal-title":"Circulation Research"},{"issue":"1","key":"10.1016\/bs.ctdb.2024.02.006_bib185","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1161\/hh0102.102271","article-title":"\u03b2-Adrenergic stimulation modulates ryanodine receptor Ca2+ release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells","volume":"90","author":"Vinogradova","year":"2002","journal-title":"Circulation Research"},{"issue":"1","key":"10.1016\/bs.ctdb.2024.02.006_bib186","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/0012-1606(80)90496-0","article-title":"The development of the conduction system in the mouse embryo heart: III. 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