{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T17:37:03Z","timestamp":1776793023519,"version":"3.51.2"},"reference-count":37,"publisher":"Elsevier","isbn-type":[{"value":"9780443220982","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.ctdb.2026.02.003","type":"book-chapter","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T10:41:42Z","timestamp":1775385702000},"page":"429-448","source":"Crossref","is-referenced-by-count":0,"title":["ASTN2 in ASD and neurodevelopmental disorders"],"prefix":"10.1016","author":[{"given":"Eve-Ellen","family":"Govek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Court","family":"Hull","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary E.","family":"Hatten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/bs.ctdb.2026.02.003_bib1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1242\/dev.129.4.965","article-title":"Mice that lack astrotactin have slowed neuronal migration","volume":"129","author":"Adams","year":"2002","journal-title":"Development (Cambridge, England)"},{"issue":"8","key":"10.1016\/bs.ctdb.2026.02.003_bib2","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/s41593-021-00872-y","article-title":"Spatial and cell type transcriptional landscape of human cerebellar development","volume":"24","author":"Aldinger","year":"2021","journal-title":"Nature Neuroscience"},{"key":"10.1016\/bs.ctdb.2026.02.003_bib3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13229-017-0137-9","article-title":"Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia","volume":"8","author":"Anney","year":"2017","journal-title":"Mol Autism"},{"key":"10.1016\/bs.ctdb.2026.02.003_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.scr.2018.05.013","article-title":"Induced pluripotent stem cells derived from a schizophrenia patient with ASTN2 deletion","volume":"30","author":"Arioka","year":"2018","journal-title":"Stem Cell Research"},{"issue":"10","key":"10.1016\/bs.ctdb.2026.02.003_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046683","article-title":"Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins","volume":"7","author":"Bayes","year":"2012","journal-title":"PLoS One"},{"issue":"41","key":"10.1016\/bs.ctdb.2026.02.003_bib6","first-page":"E9717","article-title":"ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins","volume":"115","author":"Behesti","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"10.1016\/bs.ctdb.2026.02.003_bib7","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/ng.2237","article-title":"Common variants at 12q14 and 12q24 are associated with hippocampal volume","volume":"44","author":"Bis","year":"2012","journal-title":"Nature Genetics"},{"issue":"26","key":"10.1016\/bs.ctdb.2026.02.003_bib8","doi-asserted-by":"crossref","first-page":"15085","DOI":"10.1073\/pnas.2000102117","article-title":"Novel genetic features of human and mouse Purkinje cell differentiation defined by comparative transcriptomics","volume":"117","author":"Buchholz","year":"2020","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6424","key":"10.1016\/bs.ctdb.2026.02.003_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav0581","article-title":"Cerebellar modulation of the reward circuitry and social behavior","volume":"363","author":"Carta","year":"2019","journal-title":"Science (New York, N. Y.)"},{"issue":"2","key":"10.1016\/bs.ctdb.2026.02.003_bib10","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1083\/jcb.106.2.505","article-title":"Astrotactin: A novel neuronal cell surface antigen that mediates neuron-astroglial interactions in cerebellar microcultures","volume":"106","author":"Edmondson","year":"1988","journal-title":"The Journal of Cell Biology"},{"issue":"3","key":"10.1016\/bs.ctdb.2026.02.003_bib11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s12311-012-0355-9","article-title":"Consensus paper: Pathological role of the cerebellum in autism","volume":"11","author":"Fatemi","year":"2012","journal-title":"Cerebellum (London, England)"},{"issue":"3","key":"10.1016\/bs.ctdb.2026.02.003_bib12","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1242\/dev.113.3.755","article-title":"Astrotactin provides a receptor system for CNS neuronal migration","volume":"113","author":"Fishell","year":"1991","journal-title":"Development (Cambridge, England)"},{"issue":"7246","key":"10.1016\/bs.ctdb.2026.02.003_bib13","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nature07953","article-title":"Autism genome-wide copy number variation reveals ubiquitin and neuronal genes","volume":"459","author":"Glessner","year":"2009","journal-title":"Nature"},{"issue":"34","key":"10.1016\/bs.ctdb.2026.02.003_bib14","article-title":"Mice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties","volume":"121","author":"Hanzel","year":"2024","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/bs.ctdb.2026.02.003_bib15","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1038\/s41398-024-02962-4","article-title":"Analysis of human neuronal cells carrying ASTN2 deletion associated with psychiatric disorders","volume":"14","author":"Hayashi","year":"2024","journal-title":"Transl Psychiatry"},{"issue":"2","key":"10.1016\/bs.ctdb.2026.02.003_bib16","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/jnc.15790","article-title":"Astrotactin 2 (ASTN2) regulates emotional and cognitive functions by affecting neuronal morphogenesis and monoaminergic systems","volume":"165","author":"Ito","year":"2023","journal-title":"Journal of Neurochemistry"},{"issue":"9","key":"10.1016\/bs.ctdb.2026.02.003_bib17","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/s41593-020-0665-z","article-title":"Regulation of autism-relevant behaviors by cerebellar-prefrontal cortical circuits","volume":"23","author":"Kelly","year":"2020","journal-title":"Nature Neuroscience"},{"key":"10.1016\/bs.ctdb.2026.02.003_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06085","article-title":"Cerebellar associative sensory learning defects in five mouse autism models","volume":"4","author":"Kloth","year":"2015","journal-title":"Elife"},{"issue":"11","key":"10.1016\/bs.ctdb.2026.02.003_bib19","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1016\/j.celrep.2018.08.022","article-title":"Comparative analyses of copy-number variation in autism spectrum disorder and schizophrenia reveal etiological overlap and biological insights","volume":"24","author":"Kushima","year":"2018","journal-title":"Cell Reports"},{"issue":"3","key":"10.1016\/bs.ctdb.2026.02.003_bib20","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/mp.2016.88","article-title":"High-resolution copy number variation analysis of schizophrenia in Japan","volume":"22","author":"Kushima","year":"2017","journal-title":"Molecular Psychiatry"},{"issue":"5","key":"10.1016\/bs.ctdb.2026.02.003_bib21","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.biopsych.2022.04.003","article-title":"Cross-disorder analysis of genic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder","volume":"92","author":"Kushima","year":"2022","journal-title":"Biological Psychiatry"},{"issue":"3","key":"10.1016\/bs.ctdb.2026.02.003_bib22","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1542\/peds.2007-1041","article-title":"Does cerebellar injury in premature infants contribute to the high prevalence of long-term cognitive, learning, and behavioral disability in survivors?","volume":"120","author":"Limperopoulos","year":"2007","journal-title":"Pediatrics"},{"issue":"95","key":"10.1016\/bs.ctdb.2026.02.003_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002464","article-title":"Rare copy number variation discovery and cross-disorder comparisons identify risk genes for ADHD","volume":"3","author":"Lionel","year":"2011","journal-title":"Science Translational Medicine"},{"issue":"10","key":"10.1016\/bs.ctdb.2026.02.003_bib24","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1093\/hmg\/ddt669","article-title":"Disruption of the ASTN2\/TRIM32 locus at 9q33.1 is a risk factor in males for autism spectrum disorders, ADHD and other neurodevelopmental phenotypes","volume":"23","author":"Lionel","year":"2014","journal-title":"Human Molecular Genetics"},{"issue":"1","key":"10.1016\/bs.ctdb.2026.02.003_bib25","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/s41467-017-01014-4","article-title":"A sexually dimorphic pre-stressed translational signature in CA3 pyramidal neurons of BDNF Val66Met mice","volume":"8","author":"Marrocco","year":"2017","journal-title":"Nature Communications"},{"issue":"7","key":"10.1016\/bs.ctdb.2026.02.003_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003128","article-title":"Co-expression profiling of autism genes in the mouse brain","volume":"9","author":"Menashe","year":"2013","journal-title":"PLoS Computational Biology"},{"issue":"4","key":"10.1016\/bs.ctdb.2026.02.003_bib27","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s12311-013-0462-2","article-title":"Reorganization of circuits underlying cerebellar modulation of prefrontal cortical dopamine in mouse models of autism spectrum disorder","volume":"12","author":"Rogers","year":"2013","journal-title":"Cerebellum (London, England)"},{"key":"10.1016\/bs.ctdb.2026.02.003_bib28","article-title":"A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits","author":"Shanta","year":"2025","journal-title":"medRxiv"},{"issue":"12","key":"10.1016\/bs.ctdb.2026.02.003_bib29","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1038\/s41593-017-0004-1","article-title":"Altered cerebellar connectivity in autism and cerebellar-mediated rescue of autism-related behaviors in mice","volume":"20","author":"Stoodley","year":"2017","journal-title":"Nature Neuroscience"},{"issue":"11","key":"10.1016\/bs.ctdb.2026.02.003_bib30","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1038\/s41380-018-0018-4","article-title":"Purkinje cells derived from TSC patients display hypoexcitability and synaptic deficits associated with reduced FMRP levels and reversed by rapamycin","volume":"23","author":"Sundberg","year":"2018","journal-title":"Molecular Psychiatry"},{"issue":"7413","key":"10.1016\/bs.ctdb.2026.02.003_bib31","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1038\/nature11310","article-title":"Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice","volume":"488","author":"Tsai","year":"2012","journal-title":"Nature"},{"issue":"2","key":"10.1016\/bs.ctdb.2026.02.003_bib32","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.celrep.2018.09.039","article-title":"Sensitive periods for cerebellar-mediated autistic-like behaviors","volume":"25","author":"Tsai","year":"2018","journal-title":"Cell Reports"},{"issue":"12","key":"10.1016\/bs.ctdb.2026.02.003_bib33","doi-asserted-by":"crossref","first-page":"5137","DOI":"10.1002\/hbm.23002","article-title":"Social cognition and the cerebellum: A meta-analytic connectivity analysis","volume":"36","author":"Van Overwalle","year":"2015","journal-title":"Human Brain Mapping"},{"issue":"5","key":"10.1016\/bs.ctdb.2026.02.003_bib34","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00702-014-1306-z","article-title":"Polymorphisms within ASTN2 gene are associated with age at onset of Alzheimer\u2019s disease","volume":"122","author":"Wang","year":"2015","journal-title":"Journal of Neural Transmission\u00a0(Vienna)"},{"key":"10.1016\/bs.ctdb.2026.02.003_bib35","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fpsyt.2016.00137","article-title":"Autism and classical eyeblink conditioning: Performance changes of the conditioned response related to autism spectrum disorder diagnosis","volume":"7","author":"Welsh","year":"2016","journal-title":"Front Psychiatry"},{"issue":"25","key":"10.1016\/bs.ctdb.2026.02.003_bib36","doi-asserted-by":"crossref","first-page":"8529","DOI":"10.1523\/JNEUROSCI.0032-10.2010","article-title":"Astn2, a novel member of the astrotactin gene family, regulates the trafficking of ASTN1 during glial-guided neuronal migration","volume":"30","author":"Wilson","year":"2010","journal-title":"The Journal of Neuroscience"},{"issue":"5260","key":"10.1016\/bs.ctdb.2026.02.003_bib37","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1126\/science.272.5260.417","article-title":"CNS gene encoding astrotactin, which supports neuronal migration along glial fibers","volume":"272","author":"Zheng","year":"1996","journal-title":"Science (New York, N. Y.)"}],"container-title":["Current Topics in Developmental Biology","Cerebellum Development and Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0070215326000189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0070215326000189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T16:37:45Z","timestamp":1776789465000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0070215326000189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443220982"],"references-count":37,"URL":"https:\/\/doi.org\/10.1016\/bs.ctdb.2026.02.003","relation":{},"ISSN":["0070-2153"],"issn-type":[{"value":"0070-2153","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}