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(2025). Doctoral dissertation: Investigating critical soma-germline interactions in the Drosophila testis stem cell niche. (PhD Doctoral Dissertation). Drexel University."},{"issue":"15","key":"10.1016\/bs.ctdb.2026.03.001_bib128","doi-asserted-by":"crossref","DOI":"10.1242\/dev.204785","article-title":"Sex-converted testis somatic cells acquire female-specific behaviors and alter XY germline identity","volume":"152","author":"Roach","year":"2025","journal-title":"Development (Cambridge, England)"},{"issue":"11","key":"10.1016\/bs.ctdb.2026.03.001_bib129","doi-asserted-by":"crossref","DOI":"10.1242\/dev.202542","article-title":"Mating-induced Ecdysone in the testis disrupts soma-germline contacts and stem cell cytokinesis","volume":"151","author":"Roach","year":"2024","journal-title":"Development (Cambridge, England)"},{"issue":"6","key":"10.1016\/bs.ctdb.2026.03.001_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110774","article-title":"Cell-cycle exit and stem cell differentiation are coupled through regulation of mitochondrial activity in the Drosophila testis","volume":"39","author":"Sainz de la 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