{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T20:04:26Z","timestamp":1789848266993,"version":"4.0.1"},"reference-count":112,"publisher":"Elsevier","isbn-type":[{"value":"9780443431289","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK046865"],"award-info":[{"award-number":["R01 DK046865"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21 DK139543"],"award-info":[{"award-number":["R21 DK139543"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.ctdb.2026.06.004","type":"book-chapter","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:18:04Z","timestamp":1782245884000},"page":"345-372","source":"Crossref","is-referenced-by-count":0,"title":["Transcription elongation mechanisms that control gene expression in erythropoiesis"],"prefix":"10.1016","author":[{"given":"Kaustav","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J.","family":"Bieker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.ctdb.2026.06.004_bib1","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/nrg3293","article-title":"Promoter-proximal pausing of RNA polymerase II: Emerging roles in metazoans","volume":"13","author":"Adelman","year":"2012","journal-title":"Nature Reviews Genetics"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib2","doi-asserted-by":"crossref","first-page":"e196","DOI":"10.1016\/S2352-3026(16)00021-1","article-title":"Bromodomain inhibitor OTX015 in patients with lymphoma or multiple myeloma: A dose-escalation, open-label, pharmacokinetic, phase 1 study","volume":"3","author":"Amorim","year":"2016","journal-title":"The Lancet Haematology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib3","doi-asserted-by":"crossref","unstructured":"Arif, T., Mukherjee, K., Xue, L., Catrow, J. L., Cox, J., & Bieker, J. J. (2025). STING and VDAC inhibitors attenuate inflammation and ineffective erythropoiesis caused by an altered metabolome in the Nan (EKLF\/E339D) mouse model of neonatal anemia. bioRxiv, https:\/\/doi.org\/10.64898\/2025.12.11.693792.","DOI":"10.64898\/2025.12.11.693792"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0092-8674(00)81785-7","article-title":"A SWI\/SNF-related chromatin remodeling complex, E-RC1, is required for tissue-specific transcriptional regulation by EKLF in vitro","volume":"95","author":"Armstrong","year":"1998","journal-title":"Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib5","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ajhg.2010.10.010","article-title":"A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia","volume":"87","author":"Arnaud","year":"2010","journal-title":"American Journal of Human Genetics"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib6","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.molcel.2015.01.027","article-title":"Bursty gene expression in the intact mammalian liver","volume":"58","author":"Bahar Halpern","year":"2015","journal-title":"Molecular Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib7","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cell.2010.05.028","article-title":"TIF1gamma controls erythroid cell fate by regulating transcription elongation","volume":"142","author":"Bai","year":"2010","journal-title":"Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib8","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.ydbio.2012.10.008","article-title":"TiF1-gamma plays an essential role in murine hematopoiesis and regulates transcriptional elongation of erythroid genes","volume":"373","author":"Bai","year":"2013","journal-title":"Developmental Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib9","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.molcel.2018.11.004","article-title":"Transcriptional burst initiation and polymerase pause release are key control points of transcriptional regulation","volume":"73","author":"Bartman","year":"2019","journal-title":"Molecular Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.molcel.2016.03.007","article-title":"Enhancer regulation of transcriptional bursting parameters revealed by forced chromatin looping","volume":"62","author":"Bartman","year":"2016","journal-title":"Molecular Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib11","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1182\/blood-2011-09-380485","article-title":"The hypersensitive sites of the murine beta-globin locus control region act independently to affect nuclear localization and transcriptional elongation","volume":"119","author":"Bender","year":"2012","journal-title":"Blood"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib12","first-page":"3481","article-title":"Novel promoter upstream of the human c-myc gene and regulation of c-myc expression in B-cell lymphomas","volume":"6","author":"Bentley","year":"1986","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib13","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0092-8674(88)90386-8","article-title":"Sequence requirements for premature termination of transcription in the human c-myc gene","volume":"53","author":"Bentley","year":"1988","journal-title":"Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib14","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/978-3-031-62731-6_10","article-title":"Erythroid kruppel-like factor (KLF1): A surprisingly versatile regulator of erythroid differentiation","volume":"1459","author":"Bieker","year":"2024","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib15","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1073\/pnas.95.5.2061","article-title":"CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation","volume":"95","author":"Blobel","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib16","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1093\/nar\/gkq1271","article-title":"Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation","volume":"39","author":"Bottardi","year":"2011","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib17","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/221043a0","article-title":"Factor stimulating transcription by RNA polymerase","volume":"221","author":"Burgess","year":"1969","journal-title":"Nature (London)"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib18","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1073\/pnas.48.1.81","article-title":"Deoxyribo ucleic acid-directed synthesis of ribonucleic acid by an enzyme from Escherichia coli","volume":"48","author":"Chamberlin","year":"1962","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib19","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/s41580-018-0010-5","article-title":"Born to run: Control of transcription elongation by RNA polymerase II","volume":"19","author":"Chen","year":"2018","journal-title":"Nature Reviews. Molecular Cell Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib20","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.1074\/jbc.M310044200","article-title":"Phosphorylated positive transcription elongation factor b (P-TEFb) is tagged for inhibition through association with 7SK snRNA","volume":"279","author":"Chen","year":"2004","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib21","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/nmeth.4031","article-title":"ATAC-see reveals the accessible genome by transposase-mediated imaging and sequencing","volume":"13","author":"Chen","year":"2016","journal-title":"Nature Methods"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib22","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1016\/j.cub.2006.03.092","article-title":"Transcriptional pulsing of a developmental gene","volume":"16","author":"Chubb","year":"2006","journal-title":"Current Biology: CB"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib23","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1101\/gad.325142.119","article-title":"Promoter-proximal pausing of RNA polymerase II: A nexus of gene regulation","volume":"33","author":"Core","year":"2019","journal-title":"Genes & Development"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib24","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1126\/science.1150843","article-title":"Transcription regulation through promoter-proximal pausing of RNA polymerase II","volume":"319","author":"Core","year":"2008","journal-title":"Science (New York, N. Y.)"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib25","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/227561a0","article-title":"Central dogma of molecular biology","volume":"227","author":"Crick","year":"1970","journal-title":"Nature (London)"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib26","doi-asserted-by":"crossref","first-page":"17454","DOI":"10.1073\/pnas.1213530109","article-title":"Transcriptional burst frequency and burst size are equally modulated across the human genome","volume":"109","author":"Dar","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib27","first-page":"587","article-title":"Eukaryotic gene transcription with purified components","volume":"101","author":"Dignam","year":"1983","journal-title":"Methods in Enzymology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib28","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1182\/blood-2008-03-145722","article-title":"Cross-talk of GATA-1 and P-TEFb in megakaryocyte differentiation","volume":"112","author":"Elagib","year":"2008","journal-title":"Blood"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib29","first-page":"3039","article-title":"A novel human cellular model of CDA IV enables comprehensive analysis revealing the molecular basis of the disease phenotype","volume":"141","author":"Ferrer-Vicens","year":"2023","journal-title":"Blood"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib30","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/272590a0","article-title":"DRB-induced premature termination of late adenovirus transcription","volume":"272","author":"Fraser","year":"1978","journal-title":"Nature (London)"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib31","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1128\/MCB.24.2.787-795.2004","article-title":"Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element","volume":"24","author":"Fujinaga","year":"2004","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib32","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1016\/S0021-9258(19)73796-X","article-title":"The role of deoxyribonucleic acid in ribonucleic acid synthesis. I. The purification and properties of ribonucleic acid polymerase","volume":"237","author":"Furth","year":"1962","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib33","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1093\/nar\/9.11.2589","article-title":"Clustering of RNA polymerase B molecules in the 5\u2032 moiety of the adult beta-globin gene of hen erythrocytes","volume":"9","author":"Gariglio","year":"1981","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib34","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1101\/gad.216200.113","article-title":"In vivo live imaging of RNA polymerase II transcription factories in primary cells","volume":"27","author":"Ghamari","year":"2013","journal-title":"Genes & Development"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib35","first-page":"3984","article-title":"RNA polymerase II interacts with the promoter region of the noninduced hsp70 gene in Drosophila melanogaster cells","volume":"6","author":"Gilmour","year":"1986","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib36","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1073\/pnas.78.2.727","article-title":"Specific transcription of mouse ribosomal DNA in a cell-free system that mimics control in vivo","volume":"78","author":"Grummt","year":"1981","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cell.2007.05.042","article-title":"A chromatin landmark and transcription initiation at most promoters in human cells","volume":"130","author":"Guenther","year":"2007","journal-title":"Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib38","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.cell.2009.05.047","article-title":"Control of inducible gene expression by signal-dependent transcriptional elongation","volume":"138","author":"Hargreaves","year":"2009","journal-title":"Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib39","doi-asserted-by":"crossref","first-page":"8163","DOI":"10.1016\/S0021-9258(17)39577-7","article-title":"Separation and partial characterization of three functional steps in transcription initiation by human RNA polymerase II","volume":"260","author":"Hawley","year":"1985","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib40","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1016\/S0021-9258(18)61372-9","article-title":"Functional steps in transcription initiation and reinitiation from the major late promoter in a HeLa nuclear extract","volume":"262","author":"Hawley","year":"1987","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib41","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ygeno.2010.07.009","article-title":"Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model","volume":"96","author":"Heruth","year":"2010","journal-title":"Genomics"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib42","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1128\/MCB.19.5.3496","article-title":"CREB-binding protein acetylates hematopoietic transcription factor GATA- 1 at functionally important sites","volume":"19","author":"Hung","year":"1999","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib43","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/s12864-019-5805-z","article-title":"Corrupted DNA-binding specificity and ectopic transcription underpin dominant neomorphic mutations in KLF\/SP transcription factors","volume":"20","author":"Ilsley","year":"2019","journal-title":"BMC Genomics"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib44","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1101\/SQB.1961.026.01.024","article-title":"On the regulation of gene activity","volume":"26","author":"Jacob","year":"1961","journal-title":"Cold Spring Harbor Symposia on Quantitative Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib45","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bcmd.2013.02.006","article-title":"Erythroid transcription factor EKLF\/KLF1 mutation causing congenital dyserythropoietic anemia type IV in a patient of Taiwanese origin: Review of all reported cases and development of a clinical diagnostic paradigm","volume":"51","author":"Jaffray","year":"2013","journal-title":"Blood Cells, Molecules & Diseases"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib46","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S1097-2765(01)00309-4","article-title":"Distinct mechanisms control RNA polymerase II recruitment to a tissue-specific locus control region and a downstream promoter","volume":"8","author":"Johnson","year":"2001","journal-title":"Molecular Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib47","doi-asserted-by":"crossref","first-page":"6484","DOI":"10.1128\/MCB.23.18.6484-6493.2003","article-title":"Highly restricted localization of RNA Polymerase II within a locus control region of a tissue-specific chromatin domain","volume":"23","author":"Johnson","year":"2003","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib48","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1038\/s41467-019-09982-5","article-title":"CUT&Tag for efficient epigenomic profiling of small samples and single cells","volume":"10","author":"Kaya-Okur","year":"2019","journal-title":"Nature Communications"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib49","doi-asserted-by":"crossref","first-page":"12317","DOI":"10.1074\/jbc.M010908200","article-title":"Positive transcription elongation factor B phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase","volume":"276","author":"Kim","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib50","doi-asserted-by":"crossref","first-page":"6019","DOI":"10.1093\/nar\/gkp677","article-title":"BRG1 directly regulates nucleosome structure and chromatin looping of the alpha globin locus to activate transcription","volume":"37","author":"Kim","year":"2009","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib51","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1128\/MCB.00841-08","article-title":"Postrecruitment regulation of RNA polymerase II directs rapid signaling responses at the promoters of estrogen target genes","volume":"29","author":"Kininis","year":"2009","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib52","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.exphem.2019.03.001","article-title":"KLF1 mutation E325K induces cell cycle arrest in erythroid cells differentiated from congenital dyserythropoietic anemia patient-specific induced pluripotent stem cells","volume":"73","author":"Kohara","year":"2019","journal-title":"Experimental Hematology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib53","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1126\/science.163.3874.1410","article-title":"Active center of DNA polymerase","volume":"163","author":"Kornberg","year":"1969","journal-title":"Science (New York, N. Y.)"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib54","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00444-19","article-title":"A Kruppel-like factor 1 (KLF1) mutation associated with severe congenital dyserythropoietic anemia alters its DNA-binding specificity","volume":"40","author":"Kulczynska","year":"2020","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib55","first-page":"E159","article-title":"Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes","volume":"108","author":"Lamonica","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib56","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1182\/blood-2006-07-032847","article-title":"Acetylation of GATA-1 is required for chromatin occupancy","volume":"108","author":"Lamonica","year":"2006","journal-title":"Blood"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib57","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.molcel.2021.01.002","article-title":"Enhancers predominantly regulate gene expression during differentiation via transcription initiation","volume":"81","author":"Larke","year":"2021","journal-title":"Molecular Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib58","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41586-018-0836-1","article-title":"Genomic encoding of transcriptional burst kinetics","volume":"565","author":"Larsson","year":"2019","journal-title":"Nature (London)"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib59","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1128\/MCB.23.4.1334-1340.2003","article-title":"Formation of a tissue-specific histone acetylation pattern by the hematopoietic transcription factor GATA-1","volume":"23","author":"Letting","year":"2003","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib60","doi-asserted-by":"crossref","first-page":"14075","DOI":"10.1073\/pnas.1008850107","article-title":"Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres","volume":"107","author":"Lewis","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib61","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1182\/blood.2019001234","article-title":"Chromatin occupancy and epigenetic analysis reveal new insights into the function of the GATA1 N terminus in erythropoiesis","volume":"134","author":"Ling","year":"2019","journal-title":"Blood"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib62","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/s41594-019-0288-9","article-title":"A 50 year history of technologies that drove discovery in eukaryotic transcription regulation","volume":"26","author":"Lis","year":"2019","journal-title":"Nature Structural & Molecular Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib63","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.1182\/blood.2022019495","article-title":"HEXIM1 is an essential transcription regulator during human erythropoiesis","volume":"142","author":"Lv","year":"2023","journal-title":"Blood"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib64","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1016\/j.devcel.2023.07.018","article-title":"RNA polymerase II pausing temporally coordinates cell cycle progression and erythroid differentiation","volume":"58","author":"Martell","year":"2023","journal-title":"Developmental Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib65","doi-asserted-by":"crossref","first-page":"11992","DOI":"10.1016\/S0021-9258(19)70232-4","article-title":"Multiple factors required for accurate initiation of transcription by purified RNA Polymerase II","volume":"255","author":"Matsui","year":"1980","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib66","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.cell.2015.03.010","article-title":"Native elongating transcript sequencing reveals human transcriptional activity at nucleotide resolution","volume":"161","author":"Mayer","year":"2015","journal-title":"Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111830","article-title":"EKLF\/Klf1 regulates erythroid transcription by its pioneering activity and selective control of RNA Pol II pause-release","volume":"41","author":"Mukherjee","year":"2022","journal-title":"Cell Reports"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib68","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1182\/blood.2020009903","article-title":"Regulation of RNA Polymerase II activity is essential for terminal erythroid maturation","volume":"138","author":"Murphy","year":"2021","journal-title":"Blood"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib69","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1038\/ng.2007.21","article-title":"RNA polymerase is poised for activation across the genome","volume":"39","author":"Muse","year":"2007","journal-title":"Nature Genetics"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib70","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-30839-2","article-title":"Mutant KLF1 in adult anemic nan mice leads to profound transcriptome changes and disordered erythropoiesis","volume":"8","author":"Nebor","year":"2018","journal-title":"Scientific Reports"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib71","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1073\/pnas.76.1.136","article-title":"Transcription of cloned Xenopus 5S RNA genes by X. laevis RNA Polymerase III in reconstituted systems","volume":"76","author":"Ng","year":"1979","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib72","doi-asserted-by":"crossref","first-page":"7153","DOI":"10.1073\/pnas.1722330115","article-title":"Modulation of transcriptional burst frequency by histone acetylation","volume":"115","author":"Nicolas","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib73","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev-cellbio-042020-021954","article-title":"Structural biology of RNA Polymerase II transcription: 20 years on","volume":"36","author":"Osman","year":"2020","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib74","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1038\/s41594-023-01037-0","article-title":"RNA polymerase II pausing regulates chromatin organization in erythrocytes","volume":"30","author":"Penagos-Puig","year":"2023","journal-title":"Nature Structural & Molecular Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib75","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1242\/dev.145656","article-title":"Neomorphic effects of the neonatal anemia (Nan-Eklf) mutation contribute to deficits throughout development","volume":"144","author":"Planutis","year":"2017","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib76","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.cell.2010.03.030","article-title":"c-Myc regulates transcriptional pause release","volume":"141","author":"Rahl","year":"2010","journal-title":"Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0020237","article-title":"The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis","volume":"2","author":"Ransom","year":"2004","journal-title":"PLoS Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib78","doi-asserted-by":"crossref","first-page":"e405","DOI":"10.1097\/MPH.0000000000001056","article-title":"KLF1 E325K-associated congenital dyserythropoietic anemia type IV: Insights into the variable clinical severity","volume":"40","author":"Ravindranath","year":"2018","journal-title":"Journal of Pediatric Hematology\/Oncology: Official Journal of the American Society of Pediatric Hematology\/Oncology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib79","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1146\/annurev-biochem-011520-105250","article-title":"Transcription in living cells: Molecular mechanisms of bursting","volume":"89","author":"Rodriguez","year":"2020","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib80","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.febslet.2004.12.007","article-title":"Transcriptional regulation and the role of diverse coactivators in animal cells","volume":"579","author":"Roeder","year":"2005","journal-title":"FEBS Letters"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib81","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/224234a0","article-title":"Multiple forms of DNA-dependent RNA polymerase in eukaryotic organisms","volume":"224","author":"Roeder","year":"1969","journal-title":"Nature (London)"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib82","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0092-8674(88)91087-2","article-title":"The RNA polymerase II molecule at the 5\u2032 end of the uninduced hsp70 gene of D. melanogaster is transcriptionally engaged","volume":"54","author":"Rougvie","year":"1988","journal-title":"Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib83","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1172\/JCI63597","article-title":"Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia","volume":"122","author":"Sankaran","year":"2012","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib84","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1101\/gad.1072303","article-title":"The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation","volume":"17","author":"Sawado","year":"2003","journal-title":"Genes & Development"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib85","doi-asserted-by":"crossref","first-page":"11432","DOI":"10.1073\/pnas.201394698","article-title":"The murine beta-globin locus control region regulates the rate of transcription but not the hyperacetylation of histones at the active genes","volume":"98","author":"Schubeler","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib86","doi-asserted-by":"crossref","first-page":"6160","DOI":"10.1128\/MCB.00919-08","article-title":"Acetylation of EKLF is essential for epigenetic modification and transcriptional activation of the beta-globin locus","volume":"28","author":"Sengupta","year":"2008","journal-title":"Molecular and Cellular Biology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2025.120095","article-title":"Histone methyltransferase NSD3 orchestrates early erythropoiesis by regulating erythroid progenitor cell differentiation and survival","volume":"1873","author":"Shah","year":"2026","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib88","doi-asserted-by":"crossref","first-page":"15151","DOI":"10.1073\/pnas.1004996107","article-title":"Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor","volume":"107","author":"Siatecka","year":"2010","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib89","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1182\/blood-2011-04-349985","article-title":"Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes","volume":"118","author":"Singleton","year":"2011","journal-title":"Blood"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib90","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1182\/blood-2010-03-272252","article-title":"Multiple functions of Ldb1 required for beta-globin activation during erythroid differentiation","volume":"116","author":"Song","year":"2010","journal-title":"Blood"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib91","doi-asserted-by":"crossref","first-page":"13337","DOI":"10.1073\/pnas.1405422111","article-title":"Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for beta-globin gene expression","volume":"111","author":"Soni","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib92","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/emboj.2011.450","article-title":"Dynamic long-range chromatin interactions control Myb proto-oncogene transcription during erythroid development","volume":"31","author":"Stadhouders","year":"2012","journal-title":"The EMBO Journal"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib93","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1182\/blood-2014-10-607309","article-title":"Functions of BET proteins in erythroid gene expression","volume":"125","author":"Stonestrom","year":"2015","journal-title":"Blood"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0092-8674(00)80599-1","article-title":"Fundamentally different logic of gene regulation in eukaryotes and prokaryotes","volume":"98","author":"Struhl","year":"1999","journal-title":"Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib95","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/embor.2010.131","article-title":"BRG1 helps RNA polymerase II to overcome a nucleosomal barrier during elongation, in vivo","volume":"11","author":"Subtil-Rodriguez","year":"2010","journal-title":"EMBO Reports"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib96","doi-asserted-by":"crossref","first-page":"36248","DOI":"10.1074\/jbc.M111.269167","article-title":"Genetic and genomic analyses of RNA polymerase II-pausing factor in regulation of mammalian transcription and cell growth","volume":"286","author":"Sun","year":"2011","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib97","article-title":"Safety and Efficacy of bromodomain and extra-terminal inhibitors for the treatment of hematological malignancies and solid tumors: A systematic study of clinical trials","volume":"11","author":"Sun","year":"2020","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib98","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.1198817","article-title":"Mammalian genes are transcribed with widely different bursting kinetics","volume":"332","author":"Suter","year":"2011","journal-title":"Science (New York, N. Y.)"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib99","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1073\/pnas.76.11.5750","article-title":"Early termination of heterogeneous nuclear RNA transcripts in mammalian cells: Accentuation by 5,6-dichloro 1-beta-D-ribofuranosylbenzimidazole","volume":"76","author":"Tamm","year":"1979","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib100","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-2443.2010.01481.x","article-title":"Erythropoiesis is regulated by the transcription elongation factor Foggy\/Spt5 through gata1 gene regulation","volume":"16","author":"Taneda","year":"2011","journal-title":"Genes to Cells: Devoted to Molecular & Cellular Mechanisms"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib101","doi-asserted-by":"crossref","DOI":"10.3324\/haematol.2018.209858","article-title":"Genetic disarray follows mutant KLF1-E325K expression in a congenital dyserythropoietic anemia patient","author":"Varricchio","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib102","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.celrep.2015.03.036","article-title":"ATRX plays a key role in maintaining silencing at interstitial heterochromatic loci and imprinted genes","volume":"11","author":"Voon","year":"2015","journal-title":"Cell Reports"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib103","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/0092-8674(79)90065-5","article-title":"Selective and accurate initiation of transcription at the Ad2 major late promotor in a soluble system dependent on purified RNA polymerase II and DNA","volume":"18","author":"Weil","year":"1979","journal-title":"Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib104","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1073\/pnas.46.8.1020","article-title":"Enzymatic incorporation of ribonucleoside triphosphates into the interpolynucleotide linkages of ribonucleic acid","volume":"46","author":"Weiss","year":"1960","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib105","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/emboj.2009.88","article-title":"ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands","volume":"28","author":"Welboren","year":"2009","journal-title":"The EMBO Journal"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib106","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nature13045","article-title":"ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression","volume":"508","author":"Wen","year":"2014","journal-title":"Nature (London)"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib107","doi-asserted-by":"crossref","first-page":"e128","DOI":"10.1182\/blood-2011-03-341404","article-title":"Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes","volume":"118","author":"Wong","year":"2011","journal-title":"Blood"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib108","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.molcel.2005.11.024","article-title":"P-TEFb-mediated phosphorylation of hSpt5C-terminal repeats is critical for processive transcription elongation","volume":"21","author":"Yamada","year":"2006","journal-title":"Molecular Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib109","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/S1097-2765(03)00388-5","article-title":"Inhibition of P-TEFb (CDK9\/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA","volume":"12","author":"Yik","year":"2003","journal-title":"Molecular Cell"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib110","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/ng.2007.26","article-title":"RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo","volume":"39","author":"Zeitlinger","year":"2007","journal-title":"Nature Genetics"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib111","doi-asserted-by":"crossref","first-page":"9855","DOI":"10.1073\/pnas.95.17.9855","article-title":"Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases","volume":"95","author":"Zhang","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctdb.2026.06.004_bib112","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1128\/MCB.21.7.2413-2422.2001","article-title":"Site-specific acetylation by p300 or CREB binding protein regulates erythroid Kruppel-like factor transcriptional activity via its interaction with the SWI-SNF complex","volume":"21","author":"Zhang","year":"2001","journal-title":"Molecular and Cellular Biology"}],"container-title":["Current Topics in Developmental Biology","Erythropoiesis\/Hematopoiesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0070215326000773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0070215326000773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:30:00Z","timestamp":1789846200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0070215326000773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443431289"],"references-count":112,"URL":"https:\/\/doi.org\/10.1016\/bs.ctdb.2026.06.004","relation":{},"ISSN":["0070-2153"],"issn-type":[{"value":"0070-2153","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}