{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:50:28Z","timestamp":1768254628985,"version":"3.49.0"},"reference-count":118,"publisher":"Elsevier","isbn-type":[{"value":"9780443294969","type":"print"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/bs.ctm.2024.06.003","type":"book-chapter","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T07:38:57Z","timestamp":1724917137000},"page":"133-155","source":"Crossref","is-referenced-by-count":3,"title":["Involvement of extracellular vesicles in the interaction of hosts and Toxoplasma gondii"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.ctm.2024.06.003_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-013-1084-8","article-title":"Biogenesis of extracellular vesicles (EV): Exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies","volume":"113","author":"Akers","year":"2013","journal-title":"Journal of Neurooncology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib2","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1128\/IAI.72.7.4127-4137.2004","article-title":"Toxoplasma gondii antigen-pulsed-dendritic cell-derived exosomes induce a protective immune response against T. gondii infection","volume":"72","author":"Aline","year":"2004","journal-title":"Infection and Immunity"},{"key":"10.1016\/bs.ctm.2024.06.003_bib3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3390\/pathogens11050603","article-title":"Prevalence of Toxoplasma gondii antibodies in individuals occupationally exposed to livestock in Portugal","volume":"11","author":"Almeida","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/bs.ctm.2024.06.003_bib4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.meatsci.2017.07.004","article-title":"Molecular detection of Toxoplasma gondii infection in slaughtered ruminants (sheep, goats and cattle) in Northwest Tunisia","volume":"133","author":"Amdouni","year":"2017","journal-title":"Meat Science"},{"key":"10.1016\/bs.ctm.2024.06.003_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.vetpar.2013.09.017","article-title":"Toxoplasma gondii and Neospora caninum seroprevalence in dairy sheep and goats mixed stock farming","volume":"198","author":"Anastasia","year":"2013","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib6","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s00436-022-07701-6","article-title":"Prevalence and molecular characterization of Toxoplasma gondii in different types of poultry in Greece, associated risk factors and co-existence with Eimeria spp","volume":"122","author":"Andreopoulou","year":"2023","journal-title":"Parasitology Research"},{"key":"10.1016\/bs.ctm.2024.06.003_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: Genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/bs.ctm.2024.06.003_bib8","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.vaccine.2009.01.022","article-title":"Exosomes are an effective vaccine against congenital toxoplasmosis in mice","volume":"10","author":"Beauvillain","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/bs.ctm.2024.06.003_bib9","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1016\/j.micinf.2007.07.002","article-title":"A vaccine based on exosomes secreted by a dendritic cell line confers protection against T. gondii infection in syngeneic and allogeneic mice","volume":"9","author":"Beauvillain","year":"2007","journal-title":"Microbes and Infection"},{"issue":"117","key":"10.1016\/bs.ctm.2024.06.003_bib10","article-title":"Toxoplasma gondii in the faeces of wild felids from the Atlantic Forest, Brazil","volume":"27","author":"Bolais","year":"2022","journal-title":"Mem\u00f3rias do Instituto Oswaldo Cruz"},{"key":"10.1016\/bs.ctm.2024.06.003_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.894573","article-title":"Congenital toxoplasmosis: The state of the art","volume":"10","author":"Bollani","year":"2022","journal-title":"Frontiers in Pediatrics"},{"key":"10.1016\/bs.ctm.2024.06.003_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000920","article-title":"A complex small RNA repertoire is generated by a plant\/fungal-like machinery and effected by a metazoan-like argonaute in the single-cell human parasite Toxoplasma gondii","volume":"6","author":"Braun","year":"2010","journal-title":"PLoS Pathogens"},{"key":"10.1016\/bs.ctm.2024.06.003_bib13","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1186\/s13071-023-06080-w","article-title":"Genetic diversity of Toxoplasma gondii in South America: Occurrence, immunity, and fate of infection","volume":"19","author":"Brito","year":"2023","journal-title":"Parasite Vectors"},{"issue":"1989","key":"10.1016\/bs.ctm.2024.06.003_bib14","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1128\/jcm.27.8.1787-1792.1989","article-title":"Direct and sensitive detection of a pathogenic protozoan, Toxoplasma gondii, by polymerase chain reaction","volume":"27","author":"Burg","year":"1989","journal-title":"Journal Clinical Microbiology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib15","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cellsig.2014.02.013","article-title":"Toxoplasma gondii inhibits apoptosis via a novel STAT3-miR-17-92-Bim pathway in macrophages","volume":"26","author":"Cai","year":"2014","journal-title":"Cellular Signaling"},{"key":"10.1016\/bs.ctm.2024.06.003_bib16","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1186\/1756-3305-6-356","article-title":"STAT3-dependent transactivation of miRNA genes following Toxoplasma gondii infection in macrophage","volume":"6","author":"Cai","year":"2013","journal-title":"Parasite Vectors"},{"key":"10.1016\/bs.ctm.2024.06.003_bib17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.bjid.2017.07.003","article-title":"Molecular diagnosis of symptomatic toxoplasmosis: A 9-year retrospective and prospective study in a referral laboratory in S\u00e3o Paulo, Brazil","volume":"21","author":"Camilo","year":"2017","journal-title":"The Brazilian Journal of Infectious Diseases"},{"key":"10.1016\/bs.ctm.2024.06.003_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.actatropica.2011.10.018","article-title":"Congenital parasitic infections: A review","volume":"121","author":"Carlier","year":"2012","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.ctm.2024.06.003_bib19","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1128\/JCM.40.11.4037-4044.2002","article-title":"Severe acquired toxoplasmosis in immunocompetent adult patients in French Guyana","volume":"40","author":"Carme","year":"2002","journal-title":"Journal of Clinical Microbiology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib20","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1128\/JCM.02502-12","article-title":"Genetic characterization of Toxoplasma gondii revealed highly diverse genotypes for isolates from newborns with congenital toxoplasmosis in Southeastern Brazil","volume":"51","author":"Carneiro","year":"2013","journal-title":"Journal Clinical Microbiology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0001-706X(01)00201-7","article-title":"Host cell invasion by the opportunistic pathogen Toxoplasma gondii","volume":"81","author":"Carruthers","year":"2002","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.ctm.2024.06.003_bib22","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.pt.2015.06.009","article-title":"Exosomes and other extracellular vesicles: The new communicators in parasite infections","volume":"31","author":"Coakley","year":"2015","journal-title":"Trends in Parasitology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib23","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.tcb.2008.11.003","article-title":"Shedding microvesicles: Artefacts no more","volume":"19","author":"Cocucci","year":"2008","journal-title":"Trends Cell Biology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib24","doi-asserted-by":"crossref","first-page":"5044","DOI":"10.1128\/JCM.43.10.5044-5047.2005","article-title":"Diagnosis of cerebral toxoplasmosis in AIDS patients in Brazil: Importance of molecular and immunological methods using peripheral blood samples","volume":"43","author":"Colombo","year":"2005","journal-title":"Journal Clinical Microbiology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib25","doi-asserted-by":"crossref","first-page":"1057277","DOI":"10.3389\/fvets.2023.1057277","article-title":"Toxoplasma gondii in sheep: Serological occurrence at slaughterhouse level in Italy and environmental risk factors","volume":"23","author":"Condoleo","year":"2023","journal-title":"Frontiers in Veterinary Science"},{"issue":"15","key":"10.1016\/bs.ctm.2024.06.003_bib26","article-title":"Human extracellular vesicles and correlation with two clinical forms of toxoplasmosis","volume":"3","author":"Cruz","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/bs.ctm.2024.06.003_bib27","first-page":"57","article-title":"Genetic analysis of the diversity in Toxoplasma gondii","volume":"40","author":"Dard\u00e9","year":"2004","journal-title":"Annali dell\u2019Istituto Superiore di Sanit\u00e0"},{"key":"10.1016\/bs.ctm.2024.06.003_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2022.106432","article-title":"Toxoplasmosis in human and animals around the world. Diagnosis and perspectives in the one health approach","volume":"231","author":"De Barros","year":"2022","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.ctm.2024.06.003_bib29","article-title":"Presence of atypical genotypes of Toxoplasma gondii isolated from cats in the state of Bahia, Northeast of Brazil","volume":"5","author":"De Jesus Deir\u00f3","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/bs.ctm.2024.06.003_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bjid.2023.102804","article-title":"Real-time PCR in the diagnosis of congenital toxoplasmosis","volume":"27","author":"De La Fuente Villar","year":"2023","journal-title":"The Brazilian Journal of Infectious Diseases"},{"key":"10.1016\/bs.ctm.2024.06.003_bib31","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3390\/tropicalmed8010003","article-title":"Toxoplasmosis infection during pregnancy","volume":"21","author":"Deganich","year":"2022","journal-title":"Tropical Medicine and Infectious Disease"},{"key":"10.1016\/bs.ctm.2024.06.003_bib32","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.medmal.2012.05.011","article-title":"Microparticles and infectious diseases","volume":"42","author":"Delabranch","year":"2012","journal-title":"M\u00e9decine et Maladies Infectieuses"},{"key":"10.1016\/bs.ctm.2024.06.003_bib33","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.ijpara.2009.01.005","article-title":"History of the discovery of the life cycle of Toxoplasma gondii","volume":"39","author":"Dubey","year":"2009","journal-title":"International Journal of Parasitology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib34","series-title":"Toxoplasma Gondii: The model apicomplexan: Perspectives and methods","first-page":"1","article-title":"The history and life cycle of Toxoplasma gondii","author":"Dubey","year":"2014"},{"key":"10.1016\/bs.ctm.2024.06.003_bib35","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s13071-021-04769-4","article-title":"Outbreaks of clinical toxoplasmosis in humans: Five decades of personal experience, perspectives and lessons learned","volume":"19","author":"Dubey","year":"2021","journal-title":"Parasite Vectors"},{"key":"10.1016\/bs.ctm.2024.06.003_bib36","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1550-7408.2008.00345.x","article-title":"The history of Toxoplasma gondii\u2014The first 100 years","volume":"55","author":"Dubey","year":"2008","journal-title":"Journal of Eukaryotic Microbiology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib37","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1590\/S0074-02762009000200003","article-title":"Toxoplasma gondii: 1908\u20132008, homage to Nicolle, Manceaux and Splendore","volume":"104","author":"Ferguson","year":"2009","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"10.1016\/bs.ctm.2024.06.003_bib38","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.exppara.2011.06.002","article-title":"Toxoplasma gondii isolates: Multilocus RFLP-PCR genotyping from human patients in Sao Paulo State, Brazil identified distinct genotypes","volume":"129","author":"Ferreira","year":"2011","journal-title":"Experimental Parasitology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib39","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.vetpar.2019.04.012","article-title":"The global seroprevalence of Toxoplasma gondii in pigs: A systematic review and meta-analysis","volume":"269","author":"Foroutan","year":"2019","journal-title":"Veterinary Parasitology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib40","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1128\/IAI.71.11.6392-6401.2003","article-title":"Role of cytokines and major histocompatibility complex restriction in mouse resistance to infection with a natural recombinant strain (type I-III) of Toxoplasma gondii","volume":"71","author":"Fux","year":"2003","journal-title":"Infection and Immunity"},{"key":"10.1016\/bs.ctm.2024.06.003_bib41","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00436-018-6185-z","article-title":"Real-time PCR detection of Toxoplasma gondii in surface water samples in S\u00e3o Paulo, Brazil","volume":"118","author":"Galvani","year":"2019","journal-title":"Parasite Research"},{"key":"10.1016\/bs.ctm.2024.06.003_bib42","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1645\/17-44","article-title":"Toxoplasma gondii antibodies in bulk tank milk samples of caprine dairy herds","volume":"104","author":"Gazzonis","year":"2018","journal-title":"Journal of Parasitology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.prevetmed.2019.104738","article-title":"Toxoplasma gondii in naturally infected goats: Monitoring of specific IgG levels in serum and milk during lactation and parasitic DNA detection in milk","volume":"170","author":"Gazzonis","year":"2019","journal-title":"Preventive Veterinary Medicine"},{"key":"10.1016\/bs.ctm.2024.06.003_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2020.102060","article-title":"Toxoplasma gondii infection in meat-producing small ruminants: Meat juice serology and genotyping","volume":"76","author":"Gazzonis","year":"2020","journal-title":"Parasitology International"},{"key":"10.1016\/bs.ctm.2024.06.003_bib45","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/S0002-9394(14)73976-5","article-title":"An unusually high prevalence of ocular toxoplasmosis in southern Brazil","volume":"114","author":"Glasner","year":"1992","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib46","article-title":"Formulation and evaluation of atovaquone-loaded macrophage-derived exosomes against Toxoplasma gondii: In vitro and in vivo assessment","volume":"11","author":"Goudarzi","year":"2024","journal-title":"Microbiology Spectrum"},{"key":"10.1016\/bs.ctm.2024.06.003_bib47","series-title":"Handbook of clinical neurology","first-page":"125","article-title":"Toxoplasmosis","author":"Halonen","year":"2013"},{"key":"10.1016\/bs.ctm.2024.06.003_bib48","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.fm.2017.02.010","article-title":"Toxoplasma gondii in raw and dry-cured ham: The influence of the curing process","volume":"65","author":"Herrero","year":"2017","journal-title":"Food Microbiology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib49","series-title":"Foodborne parasites","first-page":"119","article-title":"Toxoplasma gondii","author":"Hill","year":"2018"},{"key":"10.1016\/bs.ctm.2024.06.003_bib50","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0020-7519(99)00170-8","article-title":"Identification of a 200- to 300-fold repetitive 529 bp DNA fragment in Toxoplasma gondii, and its use for diagnostic and quantitative PCR\u201d","volume":"30","author":"Homan","year":"2000","journal-title":"International Journal for Parasitology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib51","doi-asserted-by":"crossref","DOI":"10.1017\/S0950268818002947","article-title":"Human toxoplasmosis: A systematic review for genetic diversity of Toxoplasma gondii in clinical samples","volume":"147","author":"Hosseini","year":"2019","journal-title":"Epidemiology and Infection"},{"key":"10.1016\/bs.ctm.2024.06.003_bib52","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.rvsc.2023.01.005","article-title":"A systematic review and meta-analysis of the serological diagnosis of Toxoplasma gondii infection highlight the lack of a One Health integrative research","volume":"155","author":"Huertas-L\u00f3pez","year":"2023","journal-title":"Research in Veterinary Science"},{"key":"10.1016\/bs.ctm.2024.06.003_bib53","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4274\/tpd.galenos.2023.38039","article-title":"An overview of one health concept focusing on Toxoplasmosis","volume":"27","author":"\u0130nci","year":"2023","journal-title":"T\u00fcrkiye parazitolojii dergis"},{"key":"10.1016\/bs.ctm.2024.06.003_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2166\/wh.2006.002","article-title":"Waterborne transmission of protozoan parasites: A worldwide review of outbreaks and lessons learnt","volume":"5","author":"Karanis","year":"2007","journal-title":"Journal of Water and Health"},{"key":"10.1016\/bs.ctm.2024.06.003_bib55","doi-asserted-by":"crossref","first-page":"5881","DOI":"10.1128\/JCM.43.12.5881-5887.2005","article-title":"Genotyping of Toxoplasma gondii strains from immunocompromised patients reveals high prevalence of type I strains","volume":"43","author":"Khan","year":"2005","journal-title":"Journal Clinical of Microbiology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib56","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3347\/kjp.2016.54.2.147","article-title":"Exosomes secreted by Toxoplasma gondii-Infected L6 cells: Their effects on host cell proliferation and cell cycle changes","volume":"54","author":"Kim","year":"2016","journal-title":"Korean Journal of Parasitology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib57","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ceb.2014.05.004","article-title":"Biogenesis and secretion of exosomes","volume":"29","author":"Kowal","year":"2014","journal-title":"Current Opinion in Cell Biology"},{"issue":"42","key":"10.1016\/bs.ctm.2024.06.003_bib58","first-page":"275","article-title":"Toxoplasma gondii infection in HIV-infected pregnant women: Epidemiology and risks of mother-to-child transmission","volume":"12","author":"Lampejo","year":"2022","journal-title":"The Pan African Medical Journal"},{"key":"10.1016\/bs.ctm.2024.06.003_bib59","first-page":"85","article-title":"Human papillomavirus infection in non-neoplastic uterine cervical disease in Hong Kong","volume":"58","author":"Lee","year":"2001","journal-title":"British Journal of Biomedical Science"},{"issue":"20","key":"10.1016\/bs.ctm.2024.06.003_bib60","doi-asserted-by":"crossref","first-page":"5506","DOI":"10.3390\/ijms20215506","article-title":"Analysis of the differential exosomal miRNAs of DC2.4 dendritic cells induced by Toxoplasma gondii infection","volume":"5","author":"Li","year":"2019","journal-title":"International Journal of Molecular Science"},{"key":"10.1016\/bs.ctm.2024.06.003_bib61","doi-asserted-by":"crossref","first-page":"467","DOI":"10.2147\/IJN.S151110","article-title":"Characterization of exosomes derived from Toxoplasma gondii and their functions in modulating immune responses","volume":"19","author":"Li","year":"2018","journal-title":"International Journal of Nanomedicine"},{"key":"10.1016\/bs.ctm.2024.06.003_bib62","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s13071-020-04255-3","article-title":"Detection of human intestinal protozoan parasites in vegetables and fruits: A review","volume":"13","author":"Li","year":"2020","journal-title":"Parasite Vectors"},{"key":"10.1016\/bs.ctm.2024.06.003_bib63","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s13071-015-0902-6","article-title":"Diagnosis of toxoplasmosis and typing of Toxoplasma gondii","volume":"28","author":"Liu","year":"2015","journal-title":"Parasite &Vectors"},{"key":"10.1016\/bs.ctm.2024.06.003_bib64","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12964-023-01103-6","article-title":"A review of the regulatory mechanisms of extracellular vesicles-mediated intercellular communication","volume":"13","author":"Liu","year":"2023","journal-title":"Cell Communication and Signaling"},{"key":"10.1016\/bs.ctm.2024.06.003_bib65","article-title":"Characterization of murine extracellular vesicles and Toxoplasma gondii infection","volume":"24","author":"Maia","year":"2021","journal-title":"Parasite Immunology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib66","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ijpara.2020.11.010","article-title":"Immunization with extracellular vesicles excreted by Toxoplasma gondii confers protection in murine infection, activating cellular and humoral responses","volume":"51","author":"Maia","year":"2021","journal-title":"International Journal of Parasitology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib67","article-title":"Determination of the viability of Toxoplasma gondii oocysts by PCR real-time after treatment with propidium monoazide","volume":"30","author":"Marciano","year":"2020","journal-title":"Revista do Instituto de Medicina Tropical de Sao Paulo"},{"key":"10.1016\/bs.ctm.2024.06.003_bib68","doi-asserted-by":"crossref","first-page":"180.13","DOI":"10.1186\/s13071-020-04040-2","article-title":"Detection of Toxoplasma gondii oocysts in fresh vegetables and berry fruits","volume":"13","author":"Marques","year":"2020","journal-title":"Parasite & Vectors"},{"key":"10.1016\/bs.ctm.2024.06.003_bib69","doi-asserted-by":"crossref","DOI":"10.1016\/j.cimid.2022.101928","article-title":"High infection rates of Toxoplasma gondii in cattle, sheep and pigs from Israel","volume":"92","author":"Mazuz","year":"2023","journal-title":"Comparative Immunology, Microbiology and Infectious Diseases"},{"key":"10.1016\/bs.ctm.2024.06.003_bib70","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1093\/cid\/cis258","article-title":"Prematurity and severity are associated with toxoplasma gondii alleles (NCCCTS, 1981\u20132009)","volume":"54","author":"McLeod","year":"2012","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/bs.ctm.2024.06.003_bib71","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.diagmicrobio.2011.07.008","article-title":"Immunodiagnosis in cerebrospinal fluid of cerebral toxoplasmosis and HIV-infected patients using Toxoplasma gondii excreted\/secreted antigens","volume":"71","author":"Meira","year":"2011","journal-title":"Diagnostic Microbiology and Infectious Disease"},{"key":"10.1016\/bs.ctm.2024.06.003_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.154990","article-title":"Ocular toxoplasmosis associated with up-regulation of miR-155-5p\/miR-29c-3p and down-regulation of miR-21-5p\/miR-125b-5p","volume":"127","author":"Meira-Strejevitch","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/bs.ctm.2024.06.003_bib73","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1099\/jmm.0.016261-0","article-title":"Real-time quantitative PCR in cerebral toxoplasmosis diagnosis of Brazilian human immunodeficiency virus-infected patients","volume":"59","author":"Mesquita","year":"2010","journal-title":"Journal Medical of Microbiology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib74","first-page":"693","article-title":"A import\u00e2ncia dos animais de produ\u00e7\u00e3o na infec\u00e7\u00e3o por Toxoplasma gondii no Brasil","volume":"29","author":"Millar","year":"2008","journal-title":"Semina:Ciencias Agrarias"},{"key":"10.1016\/bs.ctm.2024.06.003_bib75","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pt.2022.10.003","article-title":"Is the incidence of congenital toxoplasmosis declining?","volume":"39","author":"Milne","year":"2023","journal-title":"Trends in Parasitology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib76","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1111\/tbed.13741","article-title":"Contaminated water confirmed as source of infection by bioassay in an outbreak of toxoplasmosis in South Brazil","volume":"68","author":"Minuzzi","year":"2021","journal-title":"Transboundary and Emerging Diseases"},{"key":"10.1016\/bs.ctm.2024.06.003_bib77","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13071-020-3954-1","article-title":"The global serological prevalence of Toxoplasma gondii in felids during the last five decades (1967\u20132017): A systematic review and meta-analysis","volume":"13","author":"Montazeri","year":"2020","journal-title":"Parasite & Vectors"},{"key":"10.1016\/bs.ctm.2024.06.003_bib78","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis","volume":"363","author":"Montoya","year":"2004","journal-title":"The Lancet"},{"key":"10.1016\/bs.ctm.2024.06.003_bib79","first-page":"369","article-title":"Sur Un Protozoaire Nouveau Du Gondi","volume":"148","author":"Nicolle","year":"1909","journal-title":"Comptes Rendus S\u00e9ances L\u2032acad\u00e9mie Sci"},{"key":"10.1016\/bs.ctm.2024.06.003_bib80","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1089\/vbz.2015.1845","article-title":"Cross-sectional serosurvey and risk factors associated with the presence of Toxoplasma gondii antibodies in pigs in Greece","volume":"16","author":"Papatsiros","year":"2016","journal-title":"Vector-Borne and Zoonotic Diseases"},{"key":"10.1016\/bs.ctm.2024.06.003_bib81","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S1701-2163(15)31053-7","article-title":"Toxoplasmosis in pregnancy: Prevention, screening, and treatment","volume":"35","author":"Paquet","year":"2013","journal-title":"Journal of Obstetrics and Gynaecology Canada"},{"key":"10.1016\/bs.ctm.2024.06.003_bib82","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12696","article-title":"Plasma extracellular microRNAs are related to AIDS\/cerebral toxoplasmosis co-infection","volume":"42","author":"Pereira","year":"2020","journal-title":"Parasite Immunology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib83","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.2217\/fmb.09.89","article-title":"Toxoplasma gondii infection and cerebral toxoplasmosis in HIV-infected patients","volume":"4","author":"Pereira-Chioccola","year":"2009","journal-title":"Future Microbiology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib84","first-page":"977","article-title":"Seroreactivity to and avidity for recombinant antigens in toxoplasmosis","volume":"12","author":"Pfrepper","year":"2005","journal-title":"Clinical and Diagnostic Laboratory Immunology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib85","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1128\/JCM.42.4.1779-1781.2004","article-title":"Usefulness of Toxoplasma gondii- recombinant antigens in serodiagnosis of human toxoplasmosis","volume":"42","author":"Pietkiewicz","year":"2004","journal-title":"Journal Clinical Microbiology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib86","first-page":"2","article-title":"Toxoplasma gondii infection of fibroblasts causes the production of exosome-like vesicles containing a unique array of mRNA and miRNA transcripts compared to serum starvation","volume":"11","author":"Pope","year":"2013","journal-title":"Journal of Extracellular Vesicles"},{"key":"10.1016\/bs.ctm.2024.06.003_bib87","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1051\/parasite\/2019035","article-title":"Occurrence and genetic characterization of Toxoplasma gondii and Neospora caninum in slaughtered domestic rabbits in central China","volume":"26","author":"Qian","year":"2019","journal-title":"Parasite (Paris, France)"},{"key":"10.1016\/bs.ctm.2024.06.003_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2021.105915","article-title":"Characterization of extracellular vesicles isolated from types I, II and III strains of Toxoplasma gondii","volume":"219","author":"Quiarim","year":"2021","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.ctm.2024.06.003_bib89","first-page":"3848","article-title":"Seroprevalence of Toxoplasma gondii infection: An umbrella review of updated systematic reviews and meta-analyses","volume":"25","author":"Rahmanian","year":"2020","journal-title":"Journal of Family Medicine and Primary Care"},{"key":"10.1016\/bs.ctm.2024.06.003_bib90","article-title":"Proteomic and structural characterization of self-assembled vesicles from excretion\/secretion products of Toxoplasma gondii","volume":"208","author":"Ram\u00edrez-Flores","year":"2019","journal-title":"Proteomics"},{"key":"10.1016\/bs.ctm.2024.06.003_bib91","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/QCO.0000000000000275","article-title":"Molecular diagnosis of toxoplasmosis in immunocompromised patients","volume":"29","author":"Robert-Gangneux","year":"2016","journal-title":"Current Opinion in Infectious Diseases"},{"key":"10.1016\/bs.ctm.2024.06.003_bib92","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1128\/CMR.05013-11","article-title":"Epidemiology of and diagnostic strategies for toxoplasmosis","volume":"25","author":"Robert-Gangneux","year":"2012","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/bs.ctm.2024.06.003_bib93","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/INF.0b013e3181b20ed1","article-title":"Clinical relevance of placenta examination for the diagnosis of congenital toxoplasmosis","volume":"29","author":"Robert-Gangneux","year":"2010","journal-title":"The Pediatric Infectious Disease Journal"},{"key":"10.1016\/bs.ctm.2024.06.003_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2022.106411","article-title":"A systematic literature review and meta-analysis of Toxoplasma gondii seroprevalence in goats","volume":"230","author":"Rodrigues","year":"2022","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.ctm.2024.06.003_bib95","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.3390\/ani12223102","article-title":"A systematic review and meta-analysis on the occurrence of toxoplasmosis in animals slaughtered in Brazilian abattoirs","volume":"10","author":"Rossi","year":"2022","journal-title":"Animals"},{"key":"10.1016\/bs.ctm.2024.06.003_bib96","article-title":"Acute Toxoplasma infection in pregnant women worldwide: A systematic review and meta-analysis","volume":"14","author":"Rostami","year":"2019","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"10.1016\/bs.ctm.2024.06.003_bib97","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.cmi.2020.01.008","article-title":"Global prevalence of latent toxoplasmosis in pregnant women: A systematic review and meta-analysis","volume":"26","author":"Rostami","year":"2020","journal-title":"Clinical Microbiology and Infection"},{"key":"10.1016\/bs.ctm.2024.06.003_bib98","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1001\/jama.1982.03330140038029","article-title":"Toxoplasmosis infection associated with raw goat\u2019s milk","volume":"248","author":"Sacks","year":"1982","journal-title":"JAMA: The Journal of the American Medical Association"},{"key":"10.1016\/bs.ctm.2024.06.003_bib99","doi-asserted-by":"crossref","first-page":"242","DOI":"10.3389\/fimmu.2019.00242","article-title":"Advances and challenges in understanding cerebral toxoplasmosis","volume":"10","author":"Schluter","year":"2019","journal-title":"Frontiers of Immunology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib100","doi-asserted-by":"crossref","first-page":"24","DOI":"10.15252\/embr.201439363","article-title":"Exosomes and other extracellular vesicles in host\u2013pathogen interactions","volume":"16","author":"Schorey","year":"2015","journal-title":"EMBO Report"},{"key":"10.1016\/bs.ctm.2024.06.003_bib101","first-page":"1132","article-title":"Extracellular vesicles from infected cells: Potential for direct pathogenesis","volume":"20","author":"Schwab","year":"2015","journal-title":"Frontiers in Microbiology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.fawpar.2019.e00049","article-title":"Environmental transmission of Toxoplasma gondii: Oocysts in water, soil and food","volume":"15","author":"Shapiro","year":"2019","journal-title":"Food Waterborne Parasitology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib103","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1098\/rstb.2009.0087","article-title":"Genetic diversity of Toxoplasma gondii in animals and humans","volume":"364","author":"Sibley","year":"2009","journal-title":"Philosophical Ttransactions of the Royal Society of London"},{"key":"10.1016\/bs.ctm.2024.06.003_bib104","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12571","article-title":"Extracellular vesicles isolated from Toxoplasma gondii induce host immune response","volume":"40","author":"Silva","year":"2018","journal-title":"Parasite Immunology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib105","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ijpara.2020.11.001","article-title":"Control of human toxoplasmosis","volume":"51","author":"Smith","year":"2021","journal-title":"International Journal of Parasitology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib106","doi-asserted-by":"crossref","first-page":"1111509","DOI":"10.3389\/fmed.2023.1111509","article-title":"Serotyping, a challenging approach for Toxoplasma gondii typing","volume":"6","author":"Sousa","year":"2023","journal-title":"Frontiers in Medicine (Lausanne)"},{"key":"10.1016\/bs.ctm.2024.06.003_bib107","first-page":"109","article-title":"Un Nuovo Protozoa. Parassita de\u2019 Conigli","volume":"3","author":"Splendore","year":"1908","journal-title":"Revista da Sociedade Sientifica De S\u00e3o Paulo"},{"key":"10.1016\/bs.ctm.2024.06.003_bib108","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: From animals to humans","volume":"30","author":"Tenter","year":"2000","journal-title":"International Journal of Parasitology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib109","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2567","article-title":"Membrane vesicles as conveyors of immune responses","volume":"9","author":"Th\u00e9ry","year":"2009","journal-title":"Nature Reviews. Immunology"},{"issue":"10","key":"10.1016\/bs.ctm.2024.06.003_bib110","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3390\/microorganisms10030517","article-title":"Contamination of soil, water, fresh produce, and bivalve mollusks with Toxoplasma gondii oocysts: A systematic review","volume":"7","author":"Ure\u00f1a","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/bs.ctm.2024.06.003_bib111","article-title":"HIV-related cerebral toxoplasmosis revisited: Current concepts and controversies of an old disease","volume":"18","author":"Vidal","year":"2019","journal-title":"Journal of the International Association of Providers of AIDS"},{"key":"10.1016\/bs.ctm.2024.06.003_bib112","doi-asserted-by":"crossref","first-page":"4765","DOI":"10.1128\/JCM.42.10.4765-4768.2004","article-title":"PCR assay using cerebrospinal fluid for diagnosis of cerebral toxoplasmosis in Brazilian AIDS patients","volume":"42","author":"Vidal","year":"2004","journal-title":"Journal Clinical Microbiology"},{"key":"10.1016\/bs.ctm.2024.06.003_bib113","series-title":"Toxoplasma gondii: Biology and role in health and disease","first-page":"280","article-title":"Cerebral toxoplasmosis in people living with HIV\/AIDS","author":"Vidal","year":"2021"},{"key":"10.1016\/bs.ctm.2024.06.003_bib114","first-page":"1863","article-title":"A comparative study of small RNAs in Toxoplasma gondii of distinct genotypes","volume":"3","author":"Wang","year":"2012","journal-title":"Parasite & Vectors"},{"key":"10.1016\/bs.ctm.2024.06.003_bib115","article-title":"A systematic review and meta-analysis of the efficacy of anti-Toxoplasma gondii medicines in humans","volume":"22","author":"Wei","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/bs.ctm.2024.06.003_bib116","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/pmic.201600477","article-title":"Proteomic profiling of extracellular vesicles secreted from Toxoplasma gondii","volume":"17","author":"Wowk","year":"2017","journal-title":"Proteomics"},{"key":"10.1016\/bs.ctm.2024.06.003_bib117","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/apha.12458","article-title":"Strain hypothesis of Toxoplasma gondii infection on the outcome of human diseases","volume":"213","author":"Xiao","year":"2015","journal-title":"Acta Physiologica"},{"key":"10.1016\/bs.ctm.2024.06.003_bib118","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1111\/tbed.14197","article-title":"Dynamics and epidemiology of Toxoplasma gondii oocyst shedding in domestic and wild felids","volume":"69","author":"Zhu","year":"2022","journal-title":"Transboundary and Emerging Diseases"}],"container-title":["Current Topics in Membranes","Extracellular Vesicles from Basic Research to Clinical Applications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063582324000115?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063582324000115?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T19:31:18Z","timestamp":1760643078000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063582324000115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9780443294969"],"references-count":118,"URL":"https:\/\/doi.org\/10.1016\/bs.ctm.2024.06.003","relation":{},"ISSN":["1063-5823"],"issn-type":[{"value":"1063-5823","type":"print"}],"subject":[],"published":{"date-parts":[[2024]]}}}