{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:18:01Z","timestamp":1783041481996,"version":"3.54.6"},"reference-count":138,"publisher":"Elsevier","isbn-type":[{"value":"9780443429897","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2021\/05584\\u20137"],"award-info":[{"award-number":["2021\/05584\\u20137"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["310112\/2023\\u20130"],"award-info":[{"award-number":["310112\/2023\\u20130"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-03584\\u201325"],"award-info":[{"award-number":["APQ-03584\\u201325"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-01680\\u201323"],"award-info":[{"award-number":["APQ-01680\\u201323"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["APQ-06678\\u201324"],"award-info":[{"award-number":["APQ-06678\\u201324"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["BPQ-100\/2024"],"award-info":[{"award-number":["BPQ-100\/2024"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100016060","name":"Funda\u00e7\u00e3o Educacional Lucas Machado","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013275","name":"Instituto Serrapilheira","doi-asserted-by":"publisher","award":["091\/2023"],"award-info":[{"award-number":["091\/2023"]}],"id":[{"id":"10.13039\/501100013275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013275","name":"Instituto Serrapilheira","doi-asserted-by":"publisher","award":["APQ-05839\\u201323"],"award-info":[{"award-number":["APQ-05839\\u201323"]}],"id":[{"id":"10.13039\/501100013275","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.ctm.2026.01.003","type":"book-chapter","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T13:09:10Z","timestamp":1776172150000},"page":"89-117","source":"Crossref","is-referenced-by-count":0,"title":["Pathophysiological insights into ion channel dysregulation and electrical remodeling in cardiac cells during Trypanosoma cruzi infection"],"prefix":"10.1016","author":[{"given":"Ivan","family":"Lobo de Sousa Marques","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario Henrique","family":"Veiga Meireles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julliane","family":"Vasconcelos Joviano-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Roman-Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur","family":"Santos-Miranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.ctm.2026.01.003_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2019.105062","article-title":"Genomic medicine in Chagas disease","volume":"197","author":"Acosta-Herrera","year":"2019","journal-title":"Acta Tropica"},{"key":"10.1016\/bs.ctm.2026.01.003_bib2","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1161\/CIRCULATIONAHA.106.627323","article-title":"Echocardiography in Chagas heart disease","volume":"115","author":"Acquatella","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/bs.ctm.2026.01.003_bib3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1128\/AAC.01129-10","article-title":"Amiodarone Inhibits Trypanosoma cruzi infection and promotes cardiac cell recovery with gap junction and cytoskeleton reassembly In Vitro","volume":"55","author":"Adesse","year":"2011","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/bs.ctm.2026.01.003_bib4","first-page":"44","article-title":"Molecular regulation of NLRP3 inflammasome activation during parasitic infection","author":"Alonaizan","year":"2024","journal-title":"Bioscience Reports"},{"key":"10.1016\/bs.ctm.2026.01.003_bib5","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002304","article-title":"Achievements and challenges upon the implementation of a program for national control of congenital Chagas in bolivia: Results 2004\u20132009","volume":"7","author":"Alonso-Vega","year":"2013","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.lana.2025.101202","article-title":"Economic burden of Chagas disease in Brazil: A nationwide cost-of-illness study","volume":"50","author":"Andrade","year":"2025","journal-title":"Lancet Regional Health Americas"},{"key":"10.1016\/bs.ctm.2026.01.003_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0011757","article-title":"The economic burden of Chagas disease: A systematic review","volume":"17","author":"Andrade","year":"2023","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib8","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/0002-8703(78)90362-9","article-title":"Histopathology of the conducting tissue of the heart in Chagas\u2019 myocarditis","volume":"95","author":"Andrade","year":"1978","journal-title":"American Heart Journal"},{"key":"10.1016\/bs.ctm.2026.01.003_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/284729","article-title":"Genetic susceptibility to Chagas disease: An overview about the infection and about the association between disease and the immune response genes","volume":"2013","author":"Ayo","year":"2013","journal-title":"BioMed Research International"},{"key":"10.1016\/bs.ctm.2026.01.003_bib10","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.4049\/jimmunol.177.6.3515","article-title":"Cutting edge: TLR9 and TLR2 signaling together account for MyD88-dependent control of parasitemia in Trypanosoma cruzi infection","volume":"177","author":"Bafica","year":"2006","journal-title":"The Journal of Immunology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib11","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1017\/S003118202100130X","article-title":"Pro-arrhythmogenic effects of Trypanosoma cruzi conditioned medium proteins in a model of bovine chromaffin cells","volume":"148","author":"Baraibar","year":"2021","journal-title":"Parasitology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib12","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1128\/iai.64.5.1770-1777.1996","article-title":"A factor from Trypanosoma cruzi induces repetitive cytosolic free Ca2+ transients in isolated primary canine cardiac myocytes","volume":"64","author":"Barr","year":"1996","journal-title":"Infection and Immunity"},{"key":"10.1016\/bs.ctm.2026.01.003_bib13","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fcimb.2019.00464","article-title":"A novel calcium-activated potassium channel controls membrane potential and intracellular pH in Trypanosoma cruzi","volume":"9","author":"Barrera","year":"2019","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib14","doi-asserted-by":"crossref","first-page":"105","DOI":"10.4269\/ajtmh.17-0293","article-title":"Trypanosoma cruzi Infection Induces Pannexin-1 channel opening in cardiac myocytes","volume":"98","author":"Barr\u00eda","year":"2018","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/bs.ctm.2026.01.003_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.00046","article-title":"Disruption of intracellular calcium homeostasis as a therapeutic target against Trypanosoma cruzi","volume":"10","author":"Benaim","year":"2020","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib16","doi-asserted-by":"crossref","first-page":"e52","DOI":"10.1086\/605091","article-title":"An estimate of the burden of Chagas disease in the United States","volume":"49","author":"Bern","year":"2009","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib17","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ijcard.2014.07.112","article-title":"Precordial chest pain in patients with chronic Chagas disease","volume":"176","author":"Bestetti","year":"2014","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF01883861","article-title":"The ajmaline test as a method to disclose latent experimental Chagas\u2019 heart disease","volume":"3","author":"Bestetti","year":"1989","journal-title":"Cardiovascular Drugs and Therapy \/ Sponsored by the International Society of Cardiovascular Pharmacotherapy"},{"key":"10.1016\/bs.ctm.2026.01.003_bib19","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/ng1329","article-title":"ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating","volume":"36","author":"Bienengraeber","year":"2004","journal-title":"Nature Genetics"},{"key":"10.1016\/bs.ctm.2026.01.003_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2020.102213","article-title":"SCN5A gene variants as potential markers of the progression of chronic chagasic cardiac alterations","volume":"80","author":"Blasco","year":"2021","journal-title":"Parasitology International"},{"key":"10.1016\/bs.ctm.2026.01.003_bib21","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ijcard.2007.01.097","article-title":"Is Chagas cardiomyopathy an independent risk factor for patients with heart failure","volume":"126","author":"Braga","year":"2008","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib22","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3390\/pathogens14020106","article-title":"Understanding host\u2013pathogen interactions in congenital Chagas disease through transcriptomic approaches","volume":"14","author":"C\u00e1ceres","year":"2025","journal-title":"Pathogens"},{"key":"10.1016\/bs.ctm.2026.01.003_bib23","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.36660\/abc.20200342","article-title":"Menor Preval\u00eancia e Extens\u00e3o da Aterosclerose Coron\u00e1ria na Doen\u00e7a de Chagas Cr\u00f4nica por Angiotomografia Coron\u00e1ria","volume":"115","author":"Cardoso","year":"2020","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"10.1016\/bs.ctm.2026.01.003_bib24","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1474-4422(10)70042-9","article-title":"Chagas disease and stroke","volume":"9","author":"Carod-Artal","year":"2010","journal-title":"Lancet Neurology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000320248","article-title":"Stroke in asymptomatic Trypanosoma cruzi-infected patients","volume":"31","author":"Carod-Artal","year":"2011","journal-title":"Cerebrovascular Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib26","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1002\/ehf2.13648","article-title":"Mortality risk in chronic Chagas cardiomyopathy: A systematic review and meta\u2010analysis","volume":"8","author":"Chadalawada","year":"2021","journal-title":"ESC Heart Fail"},{"key":"10.1016\/bs.ctm.2026.01.003_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1590\/S0074-02761909000200008","article-title":"Nova tripanozomiaze humana: Estudos sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n. gen., n. sp., ajente etiolojico de nova entidade m\u00f3rbida do homem","volume":"2","author":"Chagas","year":"1909","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"10.1016\/bs.ctm.2026.01.003_bib28","unstructured":"Chagas disease in Latin America: An epidemiological update based on 2010 estimates. Weekly Epidemiological Record, 2015, 90, 33\u201343."},{"key":"10.1016\/bs.ctm.2026.01.003_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116651","article-title":"Voltage-gated potassium channel 1.3: A promising molecular target in multiple disease therapy","volume":"175","author":"Cheng","year":"2024","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/bs.ctm.2026.01.003_bib30","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12929-024-01032-7","article-title":"Targeting NLRP3 signaling reduces myocarditis-induced arrhythmogenesis and cardiac remodeling","volume":"31","author":"Chin","year":"2024","journal-title":"Journal of Biomedical Science"},{"key":"10.1016\/bs.ctm.2026.01.003_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138856","article-title":"Calmodulin interacts with the sodium\/calcium exchanger NCX1 to regulate activity","volume":"10","author":"Chou","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/bs.ctm.2026.01.003_bib32","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1080\/14760584.2021.1969230","article-title":"Oxidative stress implications for therapeutic vaccine development against Chagas disease","volume":"20","author":"Choudhuri","year":"2021","journal-title":"Expert Review of Vaccines"},{"key":"10.1016\/bs.ctm.2026.01.003_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192378","article-title":"Genetic association study of NLRP1, CARD, and CASP1 inflammasome genes with chronic Chagas cardiomyopathy among Trypanosoma cruzi seropositive patients in Bolivia","volume":"13","author":"Clipman","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/bs.ctm.2026.01.003_bib34","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13071-018-2614-1","article-title":"Trypanosoma cruzi activates mouse cardiac fibroblasts in vitro leading to fibroblast-myofibroblast transition and increase in expression of extracellular matrix proteins","volume":"11","author":"Coelho","year":"2018","journal-title":"Parasites & Vectors"},{"key":"10.1016\/bs.ctm.2026.01.003_bib35","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.4269\/ajtmh.15-0255","article-title":"Altered cardiomyocyte function and Trypanosoma cruzi persistence in Chagas disease","volume":"94","author":"Cruz","year":"2016","journal-title":"The American Journal of Tropical Medicine and Hygiene"},{"key":"10.1016\/bs.ctm.2026.01.003_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.lana.2024.100881","article-title":"The epidemiology of Chagas disease in the Americas","volume":"37","author":"Cucunub\u00e1","year":"2024","journal-title":"The Lancet Regional Health - Americas"},{"key":"10.1016\/bs.ctm.2026.01.003_bib37","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13071-016-1315-x","article-title":"Increased mortality attributed to Chagas disease: A systematic review and meta-analysis","volume":"9","author":"Cucunub\u00e1","year":"2016","journal-title":"Parasites & Vectors"},{"key":"10.1016\/bs.ctm.2026.01.003_bib38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.3109\/08916930109007383","article-title":"Heart-infiltrating and peripheral T cells in the pathogenesis of human Chagas\u2019 disease cardiomyopathy","volume":"34","author":"Cunha-Neto","year":"2001","journal-title":"Autoimmunity"},{"key":"10.1016\/bs.ctm.2026.01.003_bib39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1023\/A:1020811915133","article-title":"New perspectives on catheter-based ablation of ventricular tachycardia complicating Chagas\u2019 disease: Experimental evidence of the efficacy of near infrared lasers for catheter ablation of Chagas\u2019 VT","volume":"7","author":"d\u2019Avila","year":"2002","journal-title":"Journal of Interventional Cardiac Electrophysiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib40","first-page":"10","article-title":"A novel mechanosensitive channel controls osmoregulation, differentiation, and infectivity in Trypanosoma cruzi","author":"Dave","year":"2021","journal-title":"Elife"},{"key":"10.1016\/bs.ctm.2026.01.003_bib41","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jelectrocard.2021.09.011","article-title":"Noninvasive prediction of late potentials in the signal-averaged ECG in patients with chronic Chagas disease","volume":"69","author":"de Freitas Silva","year":"2021","journal-title":"Journal of Electrocardiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib42","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0035-9203(86)90330-5","article-title":"Ajmaline-induced electrocardiographic changes in chronic Trypanosoma curzl-infected rats","volume":"80","author":"de Oliveira","year":"1986","journal-title":"Transactions of the Royal Society of Tropical Medicine and Hygiene"},{"key":"10.1016\/bs.ctm.2026.01.003_bib43","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0140-6736(23)01787-7","article-title":"Chagas disease","volume":"403","author":"de Sousa","year":"2024","journal-title":"The Lancet"},{"key":"10.1016\/bs.ctm.2026.01.003_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yjmcc.2025.02.001","article-title":"Cardiac hypertrophy induced by overexpression of IP3-released inositol 1, 4, 5-trisphosphate receptor-binding protein (IRBIT","volume":"201","author":"Di Matt\u00eda","year":"2025","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib45","article-title":"NLRP3 inflammasome and pyroptosis in cardiovascular diseases and exercise intervention","volume":"15","author":"Ding","year":"2024","journal-title":"Front Pharmacol"},{"key":"10.1016\/bs.ctm.2026.01.003_bib46","doi-asserted-by":"crossref","first-page":"H1208","DOI":"10.1152\/ajpheart.00251.2012","article-title":"Cardiomyocyte ATP release through pannexin 1 aids in early fibroblast activation","volume":"303","author":"Dolmatova","year":"2012","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib47","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.cell.2008.02.048","article-title":"A dynamic pathway for calcium-independent activation of CaMKII by methionine oxidation","volume":"133","author":"Erickson","year":"2008","journal-title":"Cell"},{"key":"10.1016\/bs.ctm.2026.01.003_bib48","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ajpath.2012.03.042","article-title":"Role of SOCS2 in modulating heart damage and function in a murine model of acute Chagas disease","volume":"181","author":"Esper","year":"2012","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib49","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.cardfail.2012.06.419","article-title":"Effect of colchicine on myocardial injury induced by Trypanosoma cruzi in experimental Chagas disease","volume":"18","author":"Fernandes","year":"2012","journal-title":"Journal of Cardiac Failure"},{"key":"10.1016\/bs.ctm.2026.01.003_bib50","doi-asserted-by":"crossref","first-page":"H238","DOI":"10.1152\/ajpheart.01122.2006","article-title":"TNF-\u03b1 downregulates transient outward potassium current in rat ventricular myocytes through iNOS overexpression and oxidant species generation","volume":"293","author":"Fern\u00e1ndez-Velasco","year":"2007","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib51","first-page":"125","article-title":"Enfermedad de Chagas de transmisi\u00f3n oral","author":"Filigheddu","year":"2017"},{"key":"10.1016\/bs.ctm.2026.01.003_bib52","first-page":"2025","article-title":"Cardiac and digestive forms of Chagas disease: An update on pathogenesis, genetics, and therapeutic targets","author":"Frade","year":"2025","journal-title":"Mediators of Inflammation"},{"key":"10.1016\/bs.ctm.2026.01.003_bib53","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1186\/1471-2334-13-587","article-title":"Genetic susceptibility to Chagas disease cardiomyopathy: Involvement of several genes of the innate immunity and chemokine-dependent migration pathways","volume":"13","author":"Frade","year":"2013","journal-title":"BMC Infectious Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib54","first-page":"11","article-title":"Polymorphisms in genes affecting interferon-\u03b3 production and Th1 T cell differentiation are associated with progression to Chagas disease cardiomyopathy","author":"Frade-Barros","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib55","article-title":"Loss of ATP-sensitive potassium channel surface expression in heart failure underlies dysregulation of action potential duration and myocardial vulnerability to injury","volume":"11","author":"Gao","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/bs.ctm.2026.01.003_bib56","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003337","article-title":"Global metabolomic profiling of acute myocarditis caused by Trypanosoma cruzi infection","volume":"8","author":"Giron\u00e8s","year":"2014","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib57","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1128\/IAI.71.3.1185-1193.2003","article-title":"Evidence that development of severe cardiomyopathy in human Chagas\u2019 disease is due to a Th1-specific immune response","volume":"71","author":"Gomes","year":"2003","journal-title":"Infection and Immunity"},{"key":"10.1016\/bs.ctm.2026.01.003_bib58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001630","article-title":"Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas\u2019 disease","volume":"6","author":"Guedes","year":"2012","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib59","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s10840-020-00915-7","article-title":"Catheter ablation of ventricular tachycardia in patients with electrical storm, with a special focus on patients with Chagas disease","volume":"62","author":"Hadid","year":"2021","journal-title":"Journal of Interventional Cardiac Electrophysiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib60","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1006\/jmcc.1996.0294","article-title":"Effect of ATP depletion on kinetics of Na\/Ca exchange-mediated Ca influx in Na-loaded heart cells","volume":"29","author":"Haworth","year":"1997","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib61","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1161\/01.RES.71.1.210","article-title":"ATP dependence of calcium uptake by the Na-Ca exchanger of adult heart cells","volume":"71","author":"Haworth","year":"1992","journal-title":"Circulation Research"},{"key":"10.1016\/bs.ctm.2026.01.003_bib62","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0008-6363(03)00361-4","article-title":"Pathophysiology of the heart in Chagas\u2019 disease: Current status and new developments","volume":"60","author":"Higuchi","year":"2003","journal-title":"Cardiovascular Research"},{"key":"10.1016\/bs.ctm.2026.01.003_bib63","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.3201\/eid2807.212221","article-title":"Updated estimates and mapping for prevalence of Chagas disease among adults, United States","volume":"28","author":"Irish","year":"2022","journal-title":"Emerging Infectious Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib64","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1002\/jcb.23023","article-title":"Electrophysiological characterization of potassium conductive pathways in Trypanosoma cruzi","volume":"112","author":"Jimenez","year":"2011","journal-title":"Journal of Cellular Biochemistry"},{"key":"10.1016\/bs.ctm.2026.01.003_bib65","first-page":"55","article-title":"Stroke in Chagas disease: From pathophysiology to clinical practice","author":"Lage","year":"2022","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"key":"10.1016\/bs.ctm.2026.01.003_bib66","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1006\/expr.1996.0070","article-title":"Trypanosoma cruzi:\u00a0Involvement of Intracellular calcium in multiplication and differentiation","volume":"83","author":"Lammel","year":"1996","journal-title":"Experimental Parasitology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib67","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1113\/jphysiol.1976.sp011622","article-title":"Transient inward current underlying arrhythmogenic effects of cardiotonic steroids in Purkinje fibres","volume":"263","author":"Lederer","year":"1976","journal-title":"The Journal of Physiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib68","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S1473-3099(13)70002-1","article-title":"Global economic burden of Chagas disease: A computational simulation model","volume":"13","author":"Lee","year":"2013","journal-title":"The Lancet Infectious Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib69","doi-asserted-by":"crossref","first-page":"644","DOI":"10.3201\/eid1404.070489","article-title":"Chagas disease, France","volume":"14","author":"Lescure","year":"2008","journal-title":"Emerging Infectious Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib70","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.yjmcc.2009.04.003","article-title":"Diastolic transient inward current in long QT syndrome type 3 is caused by Ca2+ overload and inhibited by ranolazine","volume":"47","author":"Lindegger","year":"2009","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib71","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.recesp.2011.01.008","article-title":"Disfunci\u00f3n de la [Ca2+] diast\u00f3lica en cardiomiocitos aislados de pacientes chag\u00e1sicos","volume":"64","author":"L\u00f3pez","year":"2011","journal-title":"Revista Espanola de Cardiologia"},{"key":"10.1016\/bs.ctm.2026.01.003_bib72","first-page":"12","article-title":"The role of the Na+\/Ca2+ exchanger in aberrant intracellular Ca2+ in cardiomyocytes of chagas-infected rodents","author":"Lopez","year":"2022","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib73","doi-asserted-by":"crossref","first-page":"3626","DOI":"10.1093\/eurheartj\/ehy600","article-title":"Treatments targeting inotropy","volume":"40","author":"Maack","year":"2019","journal-title":"European Heart Journal"},{"key":"10.1016\/bs.ctm.2026.01.003_bib74","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02497-19","article-title":"Amlodipine increases the therapeutic potential of ravuconazole upon Trypanosoma cruzi infection","volume":"64","author":"Machado","year":"2020","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/bs.ctm.2026.01.003_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.731372","article-title":"Interaction with the extracellular matrix triggers calcium signaling in Trypanosoma cruzi prior to cell invasion","volume":"11","author":"Manchola Var\u00f3n","year":"2021","journal-title":"Frontiers in Cellular and Infection Microbiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib76","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCULATIONAHA.106.624296","article-title":"Pathogenesis of chronic chagas heart disease","volume":"115","author":"Marin-Neto","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/bs.ctm.2026.01.003_bib77","doi-asserted-by":"crossref","unstructured":"Marin-Neto J.A., Rassi Jr. A., Moraes Oliveira G.M., Lemos Correia L.C., Novaes Ramos Jr A., Hasslocher-Moreno A.M., et al. 2022. Diretriz da Sociedade Brasileira de Cardiologia sobre Diagn\u00f3stico e Tratamento de Pacientes com Cardiomiopatia da Doen\u00e7a de Chagas. Em SciELO Preprints. https:\/\/doi.org\/10.1590\/SciELOPreprints.4820.","DOI":"10.1590\/SciELOPreprints.4820"},{"key":"10.1016\/bs.ctm.2026.01.003_bib78","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1590\/0037-8682-0028-2013","article-title":"Pathogenesis of chronic Chagas cardiomyopathy: The role of coronary microvascular derangements","volume":"46","author":"Marin-Neto","year":"2013","journal-title":"Revista da Sociedade Brasileira de Medicina Tropical"},{"key":"10.1016\/bs.ctm.2026.01.003_bib79","doi-asserted-by":"crossref","first-page":"82","DOI":"10.15420\/ecr.2018.30.2","article-title":"Chagas disease and heart failure: An expanding issue worldwide","volume":"14","author":"Martinez","year":"2019","journal-title":"European Cardiology Review"},{"key":"10.1016\/bs.ctm.2026.01.003_bib80","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008162","article-title":"Increases in [IP3]i aggravates diastolic [Ca2+] and contractile dysfunction in Chagas\u2019 human cardiomyocytes","volume":"14","author":"Mijares","year":"2020","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib81","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1550226","article-title":"NLRP3 inflammasome in cardiovascular diseases: An update","volume":"16","author":"Mo","year":"2025","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib82","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1590\/S1516-31801995000200017","article-title":"Signal-averaged electrocardiogram in chronic Chagas\u2019 heart disease","volume":"113","author":"Moraes","year":"1995","journal-title":"Sao Paulo Medical Journal"},{"key":"10.1016\/bs.ctm.2026.01.003_bib83","doi-asserted-by":"crossref","first-page":"3346","DOI":"10.4049\/jimmunol.167.6.3346","article-title":"IL-12-independent IFN-\u03b3 production by T cells in experimental chagas\u2019 disease is mediated by IL-18","volume":"167","author":"M\u00fcller","year":"2001","journal-title":"The Journal of Immunology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib84","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/3039184","article-title":"ATP-Sensitive potassium channels mediate the cardioprotective effect of panax notoginseng saponins against myocardial ischaemia-reperfusion injury and inflammatory reaction","volume":"2020","author":"Ning","year":"2020","journal-title":"BioMed Research International"},{"key":"10.1016\/bs.ctm.2026.01.003_bib85","first-page":"138","article-title":"Chagas cardiomyopathy: An update of current clinical knowledge and management: A scientific statement from the American heart association","author":"Nunes","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/bs.ctm.2026.01.003_bib86","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1080\/14779072.2017.1317591","article-title":"Chagas disease immunogenetics: Elusive markers of disease progression","volume":"15","author":"Ortega Zamora","year":"2017","journal-title":"Expert Review of Cardiovascular Therapy"},{"key":"10.1016\/bs.ctm.2026.01.003_bib87","doi-asserted-by":"crossref","first-page":"H1258","DOI":"10.1152\/ajpheart.1995.268.3.H1258","article-title":"Reduction of the transient outward potassium current in a canine model of Chagas\u2019 disease","volume":"268","author":"Pacioretty","year":"1995","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib88","doi-asserted-by":"crossref","first-page":"8067","DOI":"10.1073\/pnas.0709684105","article-title":"ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way","volume":"105","author":"Piccini","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.ctm.2026.01.003_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.mehy.2021.110667","article-title":"Can extracellular vesicles produced during infection by Trypanosoma cruzi function as damage-associated molecular patterns in the host","volume":"155","author":"Pinge-Filho","year":"2021","journal-title":"Medical Hypotheses"},{"key":"10.1016\/bs.ctm.2026.01.003_bib90","first-page":"14","article-title":"Navigating drug repurposing for Chagas disease: Advances, challenges, and opportunities","author":"Porta","year":"2023","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib91","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.idc.2012.03.002","article-title":"American Trypanosomiasis (Chagas disease)","volume":"26","author":"Rassi","year":"2012","journal-title":"Infectious Disease Clinics of North America"},{"key":"10.1016\/bs.ctm.2026.01.003_bib92","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1056\/NEJMoa053241","article-title":"Development and validation of a risk score for predicting death in Chagas\u2019 heart disease","volume":"355","author":"Rassi","year":"2006","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/bs.ctm.2026.01.003_bib93","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","author":"Rassi","year":"2010","journal-title":"Lancet"},{"key":"10.1016\/bs.ctm.2026.01.003_bib94","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1590\/S0066-782X2001000100008","article-title":"Sudden death in Chagas\u2019 disease","volume":"76","author":"Rassi","year":"2001","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"10.1016\/bs.ctm.2026.01.003_bib95","first-page":"377","article-title":"Ventricular arrhythmia in Chagas disease. Diagnostic, prognostic, and therapeutic features","volume":"65","author":"Rassi J\u00fanior","year":"1995","journal-title":"Arquivos Brasileiros de Cardiologia"},{"key":"10.1016\/bs.ctm.2026.01.003_bib96","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/clin.1997.4335","article-title":"Anin situquantitative immunohistochemical study of cytokines and IL-2R+in chronic human chagasic myocarditis: Correlation with the presence of myocardialTrypanosoma cruziAntigens","volume":"83","author":"Reis","year":"1997","journal-title":"Clinical Immunology and Immunopathology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib97","doi-asserted-by":"crossref","first-page":"e439","DOI":"10.1016\/S2214-109X(17)30073-6","article-title":"Cost-effectiveness of Chagas disease screening in Latin American migrants at primary health-care centres in Europe: A Markov model analysis","volume":"5","author":"Requena-M\u00e9ndez","year":"2017","journal-title":"Lancet Global Health"},{"key":"10.1016\/bs.ctm.2026.01.003_bib98","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1365-3024.2000.00260.x","article-title":"Chagasic patients develop a type 1 immune response to Trypanosoma cruzi trans\u2010sialidase","volume":"22","author":"Ribeirao","year":"2000","journal-title":"Parasite Immunology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib99","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nrcardio.2012.109","article-title":"Diagnosis and management of Chagas disease and cardiomyopathy","volume":"9","author":"Ribeiro","year":"2012","journal-title":"Nature Reviews Cardiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib100","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1540-8167.2007.01088.x","article-title":"Prognostic value of signal\u2010averaged electrocardiogram in Chagas disease","volume":"19","author":"Ribeiro","year":"2008","journal-title":"Journal of Cardiovascular Electrophysiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib101","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/361730","article-title":"In situ expression of regulatory cytokines by heart inflammatory cells in Chagas\u2019 disease patients with heart failure","volume":"2012","author":"Rodrigues","year":"2012","journal-title":"Clinical & Developmental Immunology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib102","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1111\/febs.14947","article-title":"Identification and electrophysiological properties of a sphingosine\u2010dependent plasma membrane Ca2+ channel in Trypanosoma cruzi","volume":"286","author":"Rodriguez\u2010Duran","year":"2019","journal-title":"The FEBS Journal"},{"key":"10.1016\/bs.ctm.2026.01.003_bib103","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s00395-009-0776-x","article-title":"Changes in cellular contractility and cytokines profile during Trypanosoma cruzi infection in mice","volume":"104","author":"Roman-Campos","year":"2009","journal-title":"Basic Research in Cardiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib104","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1161\/CIRCRESAHA.124.324507","article-title":"Arrhythmogenic manifestations of Chagas disease: Perspectives From the bench to bedside","volume":"134","author":"Roman-Campos","year":"2024","journal-title":"Circulation Research"},{"key":"10.1016\/bs.ctm.2026.01.003_bib105","first-page":"10","article-title":"Impact of IFN-\u03b3 deficiency on the cardiomyocyte function in the first stage of experimental Chagas disease","author":"Roman-Campos","year":"2022","journal-title":"Microorganisms"},{"key":"10.1016\/bs.ctm.2026.01.003_bib106","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1016\/j.ijcard.2012.09.020","article-title":"Novel insights into the development of chagasic cardiomyopathy: Role of PI3Kinase\/NO axis","volume":"167","author":"Roman-Campos","year":"2013","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib107","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1590\/0074-0276108022013019","article-title":"Cardiomyocyte dysfunction during the chronic phase of Chagas disease","volume":"108","author":"Roman-Campos","year":"2013","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"10.1016\/bs.ctm.2026.01.003_bib108","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165949","article-title":"Deletion of inducible nitric oxide synthase delays the onset of cardiomyocyte electrical remodeling in experimental Chagas disease","volume":"1866","author":"Roman-Campos","year":"2020","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"10.1016\/bs.ctm.2026.01.003_bib109","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.1020826","article-title":"Pannexin1 channels-a potential therapeutic target in inflammation","volume":"10","author":"Rusiecka","year":"2022","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib110","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1161\/CIRCULATIONAHA.112.123612","article-title":"Ten-year incidence of chagas cardiomyopathy among asymptomatic Trypanosoma cruzi \u2013seropositive former blood donors","volume":"127","author":"Sabino","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/bs.ctm.2026.01.003_bib111","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202101060R","article-title":"Inhibition of calcium\/calmodulin (Ca(2+) \/CaM)-Calcium\/calmodulin-dependent protein kinase II (CaMKII) axis reduces in vitro and ex vivo arrhythmias in experimental Chagas disease","volume":"35","author":"Santos-Miranda","year":"2021","journal-title":"The FASEB Journal"},{"key":"10.1016\/bs.ctm.2026.01.003_bib112","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009421","article-title":"A novel substrate for arrhythmias in Chagas disease","volume":"15","author":"Santos-Miranda","year":"2021","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib113","first-page":"1","article-title":"Reactive oxygen species and nitric oxide imbalances lead to in vivo and in vitro arrhythmogenic phenotype in acute phase of experimental Chagas disease","volume":"16","author":"Santos-Miranda","year":"2020","journal-title":"PLoS Pathogens"},{"key":"10.1016\/bs.ctm.2026.01.003_bib114","doi-asserted-by":"crossref","first-page":"263","DOI":"10.21037\/cdt-20-302","article-title":"Pathophysiology of heart failure","volume":"11","author":"Schwinger","year":"2021","journal-title":"Cardiovascular Diagnosis and Therapy"},{"key":"10.1016\/bs.ctm.2026.01.003_bib115","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1016\/j.jacc.2018.08.2195","article-title":"Long-term prognostic value of myocardial fibrosis in patients with chagas cardiomyopathy","volume":"72","author":"Senra","year":"2018","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib116","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006747","article-title":"Modulation of host central carbon metabolism and in situ glucose uptake by intracellular Trypanosoma cruzi amastigotes","volume":"13","author":"Shah-Simpson","year":"2017","journal-title":"PLoS Pathogens"},{"key":"10.1016\/bs.ctm.2026.01.003_bib117","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1113\/jphysiol.2014.282319","article-title":"Na+\/Ca2+ exchange and Na+\/K+-ATPase in the heart","volume":"593","author":"Shattock","year":"2015","journal-title":"The Journal of Physiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib118","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1161\/hh0901.090298","article-title":"Cardiac Na(+)-Ca(2+) exchange: Molecular and pharmacological aspects","volume":"88","author":"Shigekawa","year":"2001","journal-title":"Circulation Research"},{"key":"10.1016\/bs.ctm.2026.01.003_bib119","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1093\/cid\/cir956","article-title":"Oral transmission of Chagas disease","volume":"54","author":"Shikanai-Yasuda","year":"2012","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib120","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1161\/CIRCULATIONAHA.113.002764","article-title":"Inositol 1, 4, 5-Trisphosphate receptors and human left ventricular myocytes","volume":"128","author":"Signore","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/bs.ctm.2026.01.003_bib121","doi-asserted-by":"crossref","DOI":"10.1172\/JCI35814","article-title":"Ca2+\/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart","author":"Singh","year":"2009","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/bs.ctm.2026.01.003_bib122","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.yjmcc.2012.01.021","article-title":"MyD88 mediated inflammatory signaling leads to CaMKII oxidation, cardiac hypertrophy and death after myocardial infarction","volume":"52","author":"Singh","year":"2012","journal-title":"Journal of Molecular and Cellular Cardiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib123","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1186\/s12889-024-19618-z","article-title":"Hospital case fatality and mortality related to Chagas disease in Brazil over two decades","volume":"24","author":"de\u00a0Souza","year":"2024","journal-title":"BMC Public Health"},{"key":"10.1016\/bs.ctm.2026.01.003_bib124","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1096\/fj.15-271353","article-title":"A heteromeric potassium channel involved in the modulation of the plasma membrane potential is essential for the survival of African trypanosomes","volume":"29","author":"Steinmann","year":"2015","journal-title":"The FASEB Journal"},{"key":"10.1016\/bs.ctm.2026.01.003_bib125","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1540-8167.2005.00315.x","article-title":"Sudden cardiac death in patients with Chagas heart disease and preserved left ventricular function","volume":"17","author":"Sternick","year":"2006","journal-title":"Journal of Cardiovascular Electrophysiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib126","doi-asserted-by":"crossref","first-page":"5015","DOI":"10.1038\/s41598-020-61965-5","article-title":"Genetic polymorphisms of IL17A associated with Chagas disease: Results from a meta-analysis in Latin American populations","volume":"10","author":"Strauss","year":"2020","journal-title":"Scientific Reports"},{"key":"10.1016\/bs.ctm.2026.01.003_bib127","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1007\/s11886-024-02113-7","article-title":"Chagas disease: Epidemiology, diagnosis, and treatment","volume":"26","author":"Swett","year":"2024","journal-title":"Current Cardiology Reports"},{"key":"10.1016\/bs.ctm.2026.01.003_bib128","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1086\/381892","article-title":"Elevated concentrations of CCL2 and tumor necrosis factor\u2013\u03b1 in chagasic cardiomyopathy","volume":"38","author":"Talvani","year":"2004","journal-title":"Clinical Infectious Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib129","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1086\/380803","article-title":"Chemokine receptor expression on the surface of peripheral blood mononuclear cells in chagas disease","volume":"189","author":"Talvani","year":"2004","journal-title":"The Journal of Infectious Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib130","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001205","article-title":"Selective decrease of components of the creatine kinase system and ATP synthase complex in chronic Chagas disease cardiomyopathy","volume":"5","author":"Teixeira","year":"2011","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"10.1016\/bs.ctm.2026.01.003_bib131","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1005947","article-title":"Resveratrol reverses functional chagas heart disease in mice","volume":"12","author":"Vilar-Pereira","year":"2016","journal-title":"PLoS Pathogens"},{"key":"10.1016\/bs.ctm.2026.01.003_bib132","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1161\/CIRCULATIONAHA.111.067306","article-title":"Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+ -Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation","volume":"125","author":"Voigt","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/bs.ctm.2026.01.003_bib133","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1016\/j.jacc.2018.09.035","article-title":"Left ventricular scar and prognosis in chronic chagas cardiomyopathy","volume":"72","author":"Volpe","year":"2018","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib134","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1590\/S0074-02762009000800004","article-title":"Gap junction reduction in cardiomyocytes following transforming growth factor-\u03b2 treatment and Trypanosoma cruzi infection","volume":"104","author":"Waghabi","year":"2009","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"10.1016\/bs.ctm.2026.01.003_bib135","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00424-021-02515-4","article-title":"The crosstalk between cardiomyocyte calcium and inflammasome signaling pathways in atrial fibrillation","volume":"473","author":"Wang","year":"2021","journal-title":"Pflugers Archiv: European Journal of Physiology"},{"key":"10.1016\/bs.ctm.2026.01.003_bib136","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1161\/CIRCULATIONAHA.118.035202","article-title":"Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation","volume":"138","author":"Yao","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/bs.ctm.2026.01.003_bib137","first-page":"H982","article-title":"Ca-dependent facilitation of cardiac Ca current is due to Ca-calmodulin-dependent protein kinase","volume":"267","author":"Yuan","year":"1994","journal-title":"American Journal of"},{"key":"10.1016\/bs.ctm.2026.01.003_bib138","doi-asserted-by":"crossref","first-page":"7339","DOI":"10.1038\/s41467-025-62757-z","article-title":"Lipid-mediated gating of a miniature mechanosensitive MscS channel from Trypanosoma cruzi","volume":"16","author":"Zhang","year":"2025","journal-title":"Nat Commun"}],"container-title":["Current Topics in Membranes","Ion Channels in Cellular Pathophysiology Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063582326000037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063582326000037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T00:39:57Z","timestamp":1783039197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063582326000037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443429897"],"references-count":138,"URL":"https:\/\/doi.org\/10.1016\/bs.ctm.2026.01.003","relation":{},"ISSN":["1063-5823"],"issn-type":[{"value":"1063-5823","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}