{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:14:10Z","timestamp":1783714450172,"version":"3.55.0"},"reference-count":85,"publisher":"Elsevier","isbn-type":[{"value":"9780443470905","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["APQ-06532\\u201324"],"award-info":[{"award-number":["APQ-06532\\u201324"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["APQ-00842\\u201323"],"award-info":[{"award-number":["APQ-00842\\u201323"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.ctm.2026.05.001","type":"book-chapter","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T21:17:09Z","timestamp":1781126229000},"page":"55-87","source":"Crossref","is-referenced-by-count":0,"title":["Voltage gated ion channels and breast cancer"],"prefix":"10.1016","author":[{"given":"Let\u00edcia Expedita Alves","family":"Dantas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana Menezes","family":"da Cunha Farias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor Guimar\u00e3es","family":"Honorato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Alves","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Stephanie","family":"Santiago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria Bernal","family":"Correa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enilton Aparecido","family":"Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Kushmerick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreia Laura Prates","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.ctm.2026.05.001_bib1","article-title":"T-type Ca2+ channels and their relationship with preneoplastic and neoplastic lesions in the human breast","volume":"v. 56","author":"Aguiar","year":"2023","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"10.1016\/bs.ctm.2026.05.001_bib2","series-title":"Ion channels: Molecules in action","author":"Aidley","year":"1996"},{"issue":"10125","key":"10.1016\/bs.ctm.2026.05.001_bib3","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0140-6736(17)33326-3","article-title":"Global surveillance of trends in cancer survival 2000-14 (CONCORD-3): Analysis of individual records for 37\u2008513\u2008025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries","volume":"391","author":"Allemani","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/bs.ctm.2026.05.001_bib4","doi-asserted-by":"crossref","DOI":"10.2174\/092986709787002835","article-title":"Targeting ion channels in cancer: A novel frontier in antineoplastic therapy","author":"Arcangeli","year":"2009","journal-title":"Current Medicinal Chemistry"},{"issue":"6","key":"10.1016\/bs.ctm.2026.05.001_bib5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.21873\/cgp.20147","volume":"16","author":"Assiri","year":"2019","journal-title":"Cancer Genomics & Proteomics"},{"issue":"n. 18","key":"10.1016\/bs.ctm.2026.05.001_bib6","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1200\/JCO.22.01966","article-title":"Effect of peritumoral infiltration of local anesthetic before surgery on survival in early breast cancer","volume":"v. 41","author":"Badwe","year":"2023","journal-title":"Journal of Clinical Oncology"},{"key":"10.1016\/bs.ctm.2026.05.001_bib7","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.molonc.2014.10.008","article-title":"Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-b","volume":"9","author":"Basson","year":"2015","journal-title":"Molecular Oncology"},{"issue":"4","key":"10.1016\/bs.ctm.2026.05.001_bib8","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1152\/physrev.00006.2016","article-title":"The inositol trisphosphate\/calcium signaling pathway in health and disease","volume":"96","author":"Berridge","year":"2016","journal-title":"Physiological Reviews"},{"key":"10.1016\/bs.ctm.2026.05.001_bib9","unstructured":"Bertolesi, G. E., et al. (2002). T-type Ca2+ channel blockers, pimozide and mibefradil, inhibit proliferation of retinoblastoma and breast cancer cells. In BIophysical Journal (Vol. 82, No. 1, pp. 102A-102A). 9650 Rockville Pike, BethesdA, MD 20814\u20133998 USA: Biophysical society."},{"key":"10.1016\/bs.ctm.2026.05.001_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-61258-x","article-title":"Beyond hemostasis: A snake venom serine protease with potassium channel blocking and potential antitumor activities","volume":"10","author":"Boldrini-Fran\u00e7a","year":"2020","journal-title":"Scientific Reports"},{"issue":"5","key":"10.1016\/bs.ctm.2026.05.001_bib11","doi-asserted-by":"crossref","first-page":"H2091","DOI":"10.1152\/ajpheart.00258.2004","article-title":"Endogenous testosterone increases L-type Ca2? channel expression in porcine coronary smooth muscle","volume":"287","author":"Bowles","year":"2004","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"3","key":"10.1016\/bs.ctm.2026.05.001_bib12","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA: a Cancer Journal for Clinicians"},{"issue":"1","key":"10.1016\/bs.ctm.2026.05.001_bib13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/1574892811308010004","article-title":"The need for calcium channels in cell proliferation","volume":"8","author":"Capiod","year":"2013","journal-title":"Recent Patents on Anti-cancer Drug Discovery"},{"key":"10.1016\/bs.ctm.2026.05.001_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/978-3-319-26974-0_7","article-title":"Extracellular calcium has multiple targets to control cell proliferation","volume":"898","author":"Capiod","year":"2016","journal-title":"Advances in Experimental Medicine and Biology"},{"issue":"1","key":"10.1016\/bs.ctm.2026.05.001_bib15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)81133-2","article-title":"From ionic currents to molecular mechanisms: The structure and function of voltage-gated sodium channels","volume":"26","author":"Catterall","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/bs.ctm.2026.05.001_bib16","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a003947","article-title":"Voltage-gated calcium channels","author":"Catterall","year":"2011","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"4","key":"10.1016\/bs.ctm.2026.05.001_bib17","first-page":"1016","article-title":"International union of basic and clinical pharmacology. XLVII. Voltage-gated sodium channels: Structure, function, and pharmacology","volume":"72","author":"Catterall","year":"2020","journal-title":"Pharmacological Reviews"},{"issue":"5","key":"10.1016\/bs.ctm.2026.05.001_bib18","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1016\/j.biocel.2008.11.001","article-title":"A novel adhesion molecule in human breast cancer cells: Voltage gated Na+ channel \u03b21 subunit","volume":"41","author":"Chioni","year":"2009","journal-title":"International Journal of Biochemistry & Cell Biology"},{"key":"10.1016\/bs.ctm.2026.05.001_bib19","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jsbmb.2013.03.007","article-title":"Effect of androgens on different breast cancer cells co-cultured with or without breast adipose fibroblasts","volume":"138","author":"Chottanapund","year":"2013","journal-title":"Journal of Steroid Biochemistry"},{"issue":"6","key":"10.1016\/bs.ctm.2026.05.001_bib20","first-page":"618","article-title":"Voltage gated K+ channels promote BT-474 breast cancer cell migration","volume":"30","author":"Chow","year":"2018","journal-title":"Chinese Journal of Cancer Research"},{"key":"10.1016\/bs.ctm.2026.05.001_bib21","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S1470-2045(08)70179-7","article-title":"Cancer survival in five continents: A worldwide population-based study (CONCORD)","volume":"v. 9","author":"Coleman","year":"2008","journal-title":"The Lancet Oncology"},{"issue":"10","key":"10.1016\/bs.ctm.2026.05.001_bib22","doi-asserted-by":"crossref","first-page":"473","DOI":"10.3727\/096504009789735404","article-title":"Establishment and characterization of MACL-1 and MGSO-3 cell lines derived from human primary breast cancer","volume":"17","author":"Correa","year":"2009","journal-title":"Oncology Research"},{"issue":"1","key":"10.1016\/bs.ctm.2026.05.001_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10549-015-3383-6","article-title":"A review of systematic reviews of the cost-effectiveness of hormone therapy, chemotherapy, and targeted therapy for breast cancer HHS public access","volume":"151","author":"Diaby","year":"2015","journal-title":"Breast Cancer Research and Treatment"},{"issue":"1\u20132","key":"10.1016\/bs.ctm.2026.05.001_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.mce.2003.09.028","article-title":"Estrogen and androgen regulation of plasma membrane calcium pump activity in immortalized distal tubule kidney cells","volume":"212","author":"Dick","year":"2003","journal-title":"Molecular and Cellular Endocrinology"},{"issue":"19","key":"10.1016\/bs.ctm.2026.05.001_bib25","doi-asserted-by":"crossref","first-page":"5369","DOI":"10.1113\/JP272262","article-title":"Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology","volume":"594","author":"Dolphin","year":"2016","journal-title":"The Journal of Physiology"},{"issue":"2","key":"10.1016\/bs.ctm.2026.05.001_bib26","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3892\/ijo.2013.2214","article-title":"The small GTPase RhoA regulates the expression and function of the sodium channel Nav1.5 in breast cancer cells","volume":"44","author":"Dulong","year":"2014","journal-title":"International Journal of Oncology"},{"key":"10.1016\/bs.ctm.2026.05.001_bib27","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0896-6273(00)81057-0","article-title":"Nomenclature of voltage-gated calcium channels","volume":"25","author":"Ertel","year":"2000","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/bs.ctm.2026.05.001_bib28","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1002\/ijc.29134","article-title":"A brief history of cancer: Age-old milestones underlying our current knowledge database","volume":"136","author":"Faguet","year":"2015","journal-title":"International Journal of Cancer"},{"key":"10.1016\/bs.ctm.2026.05.001_bib29","doi-asserted-by":"crossref","first-page":"5381","DOI":"10.1158\/1078-0432.CCR-05-0327","article-title":"Voltage-gated sodium channel expression and potentiation of human breast cancer metastasis","volume":"11","author":"Fraser","year":"2005","journal-title":"Clinical Cancer Research: an Official Journal of the American Association for Cancer Research"},{"key":"10.1016\/bs.ctm.2026.05.001_bib30","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.biocel.2015.12.012","article-title":"Caffeic acid phenethyl ester: Inhibition of metastatic cell behaviours via voltage gated sodium channel in human breast cancer in vitro","volume":"71","author":"Fraser","year":"2016","journal-title":"International Journal of Biochemistry & Cell Biology"},{"issue":"2","key":"10.1016\/bs.ctm.2026.05.001_bib31","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/jcp.22154","article-title":"Estrogen and non-genomic upregulation of voltage gated Na+ channel activity in MDA-MB-231 human breast cancer cells: Role in adhesion","volume":"224","author":"Fraser","year":"2010","journal-title":"Journal of Cellular Physiology"},{"issue":"4","key":"10.1016\/bs.ctm.2026.05.001_bib32","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1055\/s-2004-814445","article-title":"Testosterone regulates mRNA levels of calcium regulatory proteins in cardiac myocytes","volume":"36","author":"Golden","year":"2004","journal-title":"Hormone and Metabolic Research. Hormon- und Stoffwechselforschung. Hormones et Metabolisme"},{"issue":"6","key":"10.1016\/bs.ctm.2026.05.001_bib33","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1159\/000501802","article-title":"Epidermal growth factor potentiates migration of MDA-MB 231 breast cancer cells by increasing NaV1.5 channel expression","volume":"97","author":"Gonz\u00e1lez-Gonz\u00e1lez","year":"2019","journal-title":"Oncology"},{"issue":"3","key":"10.1016\/bs.ctm.2026.05.001_bib34","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1677\/jme.0.0320793","article-title":"Inhibition of MCF-7 breast cancer cell proliferation by 5alpha-dihydrotestosterone; a role for p21(Cip1\/Waf1)","volume":"32","author":"Greeve","year":"2004","journal-title":"Journal of Molecular Endocrinology"},{"issue":"12","key":"10.1016\/bs.ctm.2026.05.001_bib35","doi-asserted-by":"crossref","first-page":"3837","DOI":"10.1002\/jcp.24095","article-title":"Human ether \u00e0-gogo K(+) channel 1 (hEag1) regulates MDA-MB-231 breast cancer cell migration through Orai1-dependent calcium entry","volume":"227","author":"Hammadi","year":"2012","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/bs.ctm.2026.05.001_bib36","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: The next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"8","key":"10.1016\/bs.ctm.2026.05.001_bib37","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.cell.2025.12.049","article-title":"Hallmarks of cancer-then and now, and beyond","volume":"189","author":"Hanahan","year":"2026","journal-title":"Cell"},{"issue":"7","key":"10.1016\/bs.ctm.2026.05.001_bib38","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrg1379","article-title":"MicroRNAs: Small RNAs with a big role in gene regulation","volume":"5","author":"He","year":"2004","journal-title":"Nature Reviews. Genetics"},{"key":"10.1016\/bs.ctm.2026.05.001_bib39","series-title":"Ion channels of excitable membranes","author":"Hille","year":"2001"},{"issue":"7","key":"10.1016\/bs.ctm.2026.05.001_bib40","first-page":"1173","article-title":"Docosahexaenoic acid (omega-3) blocks voltage gated sodium channel activity and migration of MDA-MB-231 human breast cancer cells","volume":"38","author":"Isbilen","year":"2006","journal-title":"International Journal of Biochemistry & Cell Biology"},{"key":"10.1016\/bs.ctm.2026.05.001_bib41","article-title":"Voltage-gated potassium channels","author":"Jan","year":"2012","journal-title":"Cold Spring Harbor Perspectives in Biology"},{"issue":"4","key":"10.1016\/bs.ctm.2026.05.001_bib42","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/s41591-025-03502-3","article-title":"Global patterns and trends in breast cancer incidence and mortality across 185 countries","volume":"31","author":"Kim","year":"2025","journal-title":"Nature Medicine"},{"issue":"2","key":"10.1016\/bs.ctm.2026.05.001_bib43","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.bbcan.2005.12.001","article-title":"Calcium transport and signaling in the mammary gland: Targets for breast cancer","volume":"1765","author":"Lee","year":"2006","journal-title":"Biochimica et Biophysica Acta (BBA) - Reviews on Cancer"},{"issue":"10286","key":"10.1016\/bs.ctm.2026.05.001_bib44","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/S0140-6736(20)32381-3","article-title":"Breast cancer","volume":"397","author":"Loibl","year":"2021","journal-title":"The Lancet"},{"key":"10.1016\/bs.ctm.2026.05.001_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2025.1536165","article-title":"Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression","volume":"16","author":"Mahapatra","year":"2025","journal-title":"Frontiers in Physiology"},{"issue":"8","key":"10.1016\/bs.ctm.2026.05.001_bib46","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.7314\/APJCP.2014.15.8.3353","article-title":"Breast cancer: Major risk factors and recent developments in treatment","volume":"15","author":"Majeed","year":"2014","journal-title":"Asian Pacific Journal of Cancer Prevention: APJCP"},{"issue":"9","key":"10.1016\/bs.ctm.2026.05.001_bib47","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s12032-015-0676-x","article-title":"5\u03b1-Dihydrotestosterone regulates the expression of L-type calcium channels and calcium-binding protein regucalcin in human breast cancer cells with suppression of cell growth","volume":"32","author":"Marques","year":"2015","journal-title":"Medical Oncology (Northwood, London, England)"},{"issue":"n. 11","key":"10.1016\/bs.ctm.2026.05.001_bib48","first-page":"1339","article-title":"Treatment of breast cancer","volume":"v. 81","author":"Maughan","year":"2010","journal-title":"American Family Physician"},{"issue":"6","key":"10.1016\/bs.ctm.2026.05.001_bib49","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrc.2017.18","article-title":"The calcium-cancer signalling nexus","volume":"17","author":"Monteith","year":"2017","journal-title":"Nature Reviews. Cancer"},{"issue":"32","key":"10.1016\/bs.ctm.2026.05.001_bib50","doi-asserted-by":"crossref","first-page":"32914","DOI":"10.18632\/oncotarget.5441","article-title":"Nav1.5 regulates breast tumor growth and metastatic dissemination in vivo","volume":"6","author":"Nelson","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/bs.ctm.2026.05.001_bib51","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2012.1422","article-title":"T-type voltage-activated calcium channel Cav3.1, but not Cav3.2, is involved in the inhibition of proliferation and apoptosis in MCF-7 human breast cancer cells","author":"Ohkubo","year":"2012","journal-title":"International Journal of Oncology"},{"issue":"11","key":"10.1016\/bs.ctm.2026.05.001_bib52","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/pros.21157","article-title":"Androgens regulate adenylate cyclase activity and intracellular calcium in stromal cells derived from human prostate","volume":"70","author":"Oliver","year":"2010","journal-title":"The Prostate"},{"key":"10.1016\/bs.ctm.2026.05.001_bib53","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev-physiol-021014-071846","article-title":"Sodium channel \u03b2 subunits: Emerging targets in channelopathies","volume":"77","author":"O\u2019Malley","year":"2015","journal-title":"Annual Review of Physiology"},{"issue":"2","key":"10.1016\/bs.ctm.2026.05.001_bib54","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/gye.16.2.113.120","article-title":"Testosterone and 5 alpha-dihydrotestosterone inhibit in vitro growth of human breast cancer cell lines","volume":"16","author":"Ortmann","year":"2002","journal-title":"Gynecological Endocrinology: the Official Journal of the International Society of Gynecological Endocrinology"},{"issue":"5","key":"10.1016\/bs.ctm.2026.05.001_bib55","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00424-015-1784-3","article-title":"Kv10.1 K(+) channel: From physiology to cancer","volume":"468","author":"Ouadid-Ahidouch","year":"2016","journal-title":"Pflugers Archiv: European Journal of Physiology"},{"issue":"1","key":"10.1016\/bs.ctm.2026.05.001_bib56","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1006\/bbrc.2000.3790","article-title":"KV1.1 K+ channels identification in human breast carcinoma cells: Involvement in cell proliferation","volume":"278","author":"Ouadid-Ahidouch","year":"2000","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"10","key":"10.1016\/bs.ctm.2026.05.001_bib57","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1002\/glia.22967","article-title":"Sodium channels in astroglia and microglia","volume":"64","author":"Pappalardo","year":"2016","journal-title":"Glia"},{"issue":"20","key":"10.1016\/bs.ctm.2026.05.001_bib58","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.1093\/emboj\/18.20.5540","article-title":"Oncogenic potential of EAG K(+) channels","volume":"18","author":"Pardo","year":"1999","journal-title":"The EMBO Journal"},{"key":"10.1016\/bs.ctm.2026.05.001_bib59","article-title":"Potassium channel-driven bioelectric signalling regulates metastasis in triple-negative breast cancer","volume":"v. 75","author":"Payne","year":"2022","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/bs.ctm.2026.05.001_bib60","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.3892\/ol.2017.6457","article-title":"Voltage-gated calcium channels: Novel targets for cancer therapy","volume":"14","author":"Phan","year":"2017","journal-title":"Oncology Letters"},{"issue":"4","key":"10.1016\/bs.ctm.2026.05.001_bib61","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1182\/blood-2006-02-003772","article-title":"VEGFR-1 (FLT-1), beta1 integrin, and hERG K+ channel for a macromolecular signaling complex in acute myeloid leukemia: Role in cell migration and clinical outcome","volume":"110","author":"Pillozzi","year":"2007","journal-title":"Blood"},{"issue":"2","key":"10.1016\/bs.ctm.2026.05.001_bib62","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1152\/physrev.00044.2016","article-title":"Ion channels in cancer: Are cancer hallmarks oncochannelopathies?","volume":"98","author":"Prevarskaya","year":"2018","journal-title":"Physiological Reviews"},{"issue":"n. 9","key":"10.1016\/bs.ctm.2026.05.001_bib63","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00424-025-03106-3","article-title":"Voltage-gated Na+ channels: Key players in the early tumorigenesis of breast cancer","volume":"v. 477","author":"Rhana","year":"2025","journal-title":"Pfl\u00fcgers Archiv \u2013 European Journal of Physiology"},{"issue":"7","key":"10.1016\/bs.ctm.2026.05.001_bib64","doi-asserted-by":"crossref","DOI":"10.1590\/1414-431x20176011","article-title":"Is there a role for voltage-gated Na+ channels in the aggressiveness of breast cancer?","volume":"50","author":"Rhana","year":"2017","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"10.1016\/bs.ctm.2026.05.001_bib65","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3389\/fnins.2020.00404","article-title":"Human breast cancer cells demonstrate electrical excitability","volume":"14","author":"Ribeiro","year":"2020","journal-title":"Frontiers in Neuroscience"},{"key":"10.1016\/bs.ctm.2026.05.001_bib66","doi-asserted-by":"crossref","first-page":"5986","DOI":"10.3390\/s120505986","article-title":"Eag1 channels as potential cancer biomarkers","volume":"12","author":"Rodriguez-Rasgado","year":"2012","journal-title":"Sensors"},{"issue":"4","key":"10.1016\/bs.ctm.2026.05.001_bib67","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/sj.bjp.0705649","article-title":"Particular sensitivity to calcium channel blockers of the fast inward voltage gated sodium current involved in the invasive properties of a metastatic breast cancer cell line","volume":"141","author":"Roger","year":"2004","journal-title":"British Journal of Pharmacology"},{"issue":"n. 1","key":"10.1016\/bs.ctm.2026.05.001_bib68","doi-asserted-by":"crossref","DOI":"10.1080\/19336950.2023.2297605","article-title":"Novel insights into voltage-gated ion channels: Translational breakthroughs in medical oncology","volume":"v. 18","author":"Sakellakis","year":"2024","journal-title":"Channels"},{"issue":"7083","key":"10.1016\/bs.ctm.2026.05.001_bib69","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature04710","article-title":"hERG potassium channels and cardiac arrhythmia","volume":"440","author":"Sanguinetti","year":"2006","journal-title":"Nature"},{"issue":"1","key":"10.1016\/bs.ctm.2026.05.001_bib70","first-page":"12","article-title":"Cancer statistics, 2024","volume":"74","author":"Siegel","year":"2024","journal-title":"CA: a Cancer Journal for Clinicians"},{"issue":"10 Pt B","key":"10.1016\/bs.ctm.2026.05.001_bib71","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.1016\/j.bbamem.2014.08.016","article-title":"Altered calcium signaling in cancer cells","volume":"1848","author":"Stewart","year":"2015","journal-title":"Biochimica et Biophysica Acta"},{"issue":"12","key":"10.1016\/bs.ctm.2026.05.001_bib72","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1016\/j.febslet.2006.03.062","article-title":"Potassium channels as tumour markers","volume":"580","author":"St\u00fchmer","year":"2006","journal-title":"FEBS Letters"},{"key":"10.1016\/bs.ctm.2026.05.001_bib73","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.canlet.2008.03.032","article-title":"Selective blockade of T-type Ca2+ channels suppresses human breast cancer cell proliferation","volume":"267","author":"Taylor","year":"2008","journal-title":"Cancer Letters"},{"key":"10.1016\/bs.ctm.2026.05.001_bib74","article-title":"Chloroquine inhibits tumor-related Kv10.1 channel and decreases migration of MDA-MB-231 breast cancer cells in vitro","volume":"856","author":"Vald\u00e9s-Abad\u00eda","year":"2019","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/bs.ctm.2026.05.001_bib75","series-title":"The genetic basis of human cancer","year":"2002"},{"issue":"n. 3","key":"10.1016\/bs.ctm.2026.05.001_bib76","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/jama.2018.19323","article-title":"Breast cancer treatment: A review","volume":"v. 321","author":"Waks","year":"2019","journal-title":"JAMA: the Journal of the American Medical Association"},{"key":"10.1016\/bs.ctm.2026.05.001_bib77","article-title":"Meta-analysis of public microarray datasets reveals voltage-gated calcium gene signatures in clinical cancerpatients","author":"Wang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/bs.ctm.2026.05.001_bib78","article-title":"Cav3.2 T-type calcium channels and cancer proliferation and progression","author":"Wang","year":"2020","journal-title":"Frontiers in Physiology"},{"issue":"8","key":"10.1016\/bs.ctm.2026.05.001_bib79","doi-asserted-by":"crossref","first-page":"749","DOI":"10.3390\/membranes12080749","article-title":"Diindolylmethane derivatives: New selective blockers for T-type calcium channels","volume":"12","author":"Wang","year":"2022","journal-title":"Membranes"},{"issue":"12","key":"10.1016\/bs.ctm.2026.05.001_bib80","first-page":"2235","article-title":"Suppression of PPAR\u03b2, and DHA treatment, inhibit NaV1.5 and NHE-1 pro-invasive activities","volume":"466","author":"Wannous","year":"2014","journal-title":"Pfl\u00fcgers Archiv - European Journal of Physiology"},{"key":"10.1016\/bs.ctm.2026.05.001_bib81","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.canlet.2021.07.017","article-title":"Calcium channel TRPV6 promotes breast cancer metastasis by NFATC2IP","volume":"519","author":"Xu","year":"2021","journal-title":"Cancer Letters"},{"issue":"2","key":"10.1016\/bs.ctm.2026.05.001_bib82","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10549-012-2102-9","article-title":"Therapeutic potential for phenytoin: Targeting NaV1.5 sodium channels to reduce migration and invasion in metastatic breast cancer","volume":"134","author":"Yang","year":"2012","journal-title":"Breast Cancer Research and Treatment"},{"key":"10.1016\/bs.ctm.2026.05.001_bib83","doi-asserted-by":"crossref","DOI":"10.1124\/pr.114.009654","article-title":"The physiology, pathology, and pharmacology of voltage-gated calcium channels","author":"Zamponi","year":"2015","journal-title":"Pharmacological Reviews"},{"issue":"22","key":"10.1016\/bs.ctm.2026.05.001_bib84","doi-asserted-by":"crossref","first-page":"8365","DOI":"10.1158\/0008-5472.CAN-04-2146","article-title":"Evidence that TRPM8 is an androgen-dependent Ca2? channel required for the survival of prostate cancer cells","volume":"64","author":"Zhang","year":"2004","journal-title":"Cancer Research"},{"key":"10.1016\/bs.ctm.2026.05.001_bib85","series-title":"Handbook of ion channels","author":"Zheng","year":"2015"}],"container-title":["Current Topics in Membranes","Ion Channels in Cellular Pathophysiology - Part B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063582326000219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063582326000219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T19:33:43Z","timestamp":1783712023000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063582326000219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443470905"],"references-count":85,"URL":"https:\/\/doi.org\/10.1016\/bs.ctm.2026.05.001","relation":{},"ISSN":["1063-5823"],"issn-type":[{"value":"1063-5823","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}