{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:36:40Z","timestamp":1764225400697,"version":"build-2065373602"},"reference-count":83,"publisher":"Elsevier","isbn-type":[{"type":"print","value":"9780128126387"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1016\/bs.enz.2017.08.006","type":"book-chapter","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T04:01:06Z","timestamp":1507867266000},"page":"81-103","source":"Crossref","is-referenced-by-count":1,"title":["Insights on the HLA-Binding Peptidome in Cancer"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.enz.2017.08.006_bb0010","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1007\/s12282-009-0124-x","article-title":"Gene and chromosomal alterations in sporadic breast cancer: correlation with histopathological features and implications for genesis and progression","volume":"16","author":"Tsuda","year":"2009","journal-title":"Breast Cancer"},{"key":"10.1016\/bs.enz.2017.08.006_bb0015","doi-asserted-by":"crossref","first-page":"195","DOI":"10.3109\/07357908909038285","article-title":"The molecular biology of CML: a review","volume":"7","author":"Leibowitz","year":"1989","journal-title":"Cancer Invest."},{"key":"10.1016\/bs.enz.2017.08.006_bb0020","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/nrc4018","article-title":"Directly targeting transcriptional dysregulation in cancer","volume":"15","author":"Gonda","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/bs.enz.2017.08.006_bb0025","doi-asserted-by":"crossref","first-page":"994","DOI":"10.3390\/cancers3010994","article-title":"Role of p53 in cell death and human cancers","volume":"3","author":"Ozaki","year":"2011","journal-title":"Cancers (Basel)"},{"key":"10.1016\/bs.enz.2017.08.006_bb0030","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.cell.2012.03.003","article-title":"MYC on the path to cancer","volume":"149","author":"Dang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/bs.enz.2017.08.006_bb0035","doi-asserted-by":"crossref","first-page":"ra56","DOI":"10.1126\/scisignal.2001754","article-title":"AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer","volume":"4","author":"Chan","year":"2011","journal-title":"Sci. Signal."},{"key":"10.1016\/bs.enz.2017.08.006_bb0040","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1073\/pnas.96.7.3940","article-title":"Transient excess of MYC activity can elicit genomic instability and tumorigenesis","volume":"96","author":"Felsher","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/bs.enz.2017.08.006_bb0045","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1021\/pr800641v","article-title":"Turnover of the human proteome: determination of protein intracellular stability by dynamic SILAC","volume":"8","author":"Doherty","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/bs.enz.2017.08.006_bb0050","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s12915-014-0094-0","article-title":"Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy","volume":"12","author":"Deshaies","year":"2014","journal-title":"BMC Biol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0055","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrc3844","article-title":"VHL, the story of a tumour suppressor gene","volume":"15","author":"Gossage","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/bs.enz.2017.08.006_bb0060","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1080\/19491034.2016.1267092","article-title":"The BRCA1 ubiquitin ligase function sets a new trend for remodelling in DNA repair","volume":"8","author":"Densham","year":"2017","journal-title":"Nucleus"},{"key":"10.1016\/bs.enz.2017.08.006_bb0065","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/1568009616666151112122231","article-title":"The SCF-type E3 ubiquitin ligases as cancer targets","volume":"16","author":"Kitagawa","year":"2016","journal-title":"Curr. Cancer Drug Targets"},{"key":"10.1016\/bs.enz.2017.08.006_bb0070","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.cell.2017.04.023","article-title":"The logic of the 26S proteasome","volume":"169","author":"Collins","year":"2017","journal-title":"Cell"},{"key":"10.1016\/bs.enz.2017.08.006_bb0075","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.coi.2011.12.002","article-title":"Proteasome subtypes and the processing of tumor antigens: increasing antigenic diversity","volume":"24","author":"Vigneron","year":"2012","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0080","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.4049\/jimmunol.1402455","article-title":"Definition of proteasomal peptide splicing rules for high-efficiency spliced peptide presentation by MHC class I molecules","volume":"195","author":"Berkers","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0085","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0161-5890(02)00098-6","article-title":"The importance of the proteasome and subsequent proteolytic steps in the generation of antigenic peptides","volume":"39","author":"Goldberg","year":"2002","journal-title":"Mol. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0090","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1093\/jnci\/djt184","article-title":"MHC class I antigen processing and presenting machinery: organization, function, and defects in tumor cells","volume":"105","author":"Leone","year":"2013","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/bs.enz.2017.08.006_bb0095","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1093\/emboj\/20.10.2357","article-title":"26S proteasomes and immunoproteasomes produce mainly N-extended versions of an antigenic peptide","volume":"20","author":"Cascio","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/bs.enz.2017.08.006_bb0100","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2015.1048956","article-title":"Designing CAR T cells for glioblastoma","volume":"4","author":"Maus","year":"2015","journal-title":"Oncoimmunology"},{"key":"10.1016\/bs.enz.2017.08.006_bb0105","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1016\/j.molimm.2009.06.021","article-title":"Proteomic identification of an MHC-binding peptidome from pancreas and breast cancer cell lines","volume":"46","author":"Antwi","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0110","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molimm.2015.04.014","article-title":"Proteolytic enzymes involved in MHC class I antigen processing: a guerrilla army that partners with the proteasome","volume":"68","author":"Lazaro","year":"2015","journal-title":"Mol. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0115","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.0500721102","article-title":"The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a \u201cmolecular ruler\u201d mechanism","volume":"102","author":"Chang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/bs.enz.2017.08.006_bb0120","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/ni.2107","article-title":"The carboxypeptidase ACE shapes the MHC class I peptide repertoire","volume":"12","author":"Shen","year":"2011","journal-title":"Nat. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0125","first-page":"216","article-title":"The ABCs of immunology: structure and function of TAP, the transporter associated with antigen processing","volume":"19","author":"Abele","year":"2004","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/bs.enz.2017.08.006_bb0130","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.coi.2016.03.007","article-title":"Immunology by numbers: quantitation of antigen presentation completes the quantitative milieu of systems immunology!","volume":"40","author":"Purcell","year":"2016","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0135","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0198-8859(02)00787-5","article-title":"Competition-based cellular peptide binding assays for 13 prevalent HLA class I alleles using fluorescein-labeled synthetic peptides","volume":"64","author":"Kessler","year":"2003","journal-title":"Hum. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0140","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.4049\/jimmunol.157.6.2539","article-title":"Improved induction of melanoma-reactive CTL with peptides from the melanoma antigen gp 100 modified at HLA-A*0201-binding residues","volume":"157","author":"Parkhurst","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0145","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.coi.2014.01.004","article-title":"New insights into cancer immunoediting and its three component phases\u2014elimination, equilibrium and escape","volume":"27","author":"Mittal","year":"2014","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0150","doi-asserted-by":"crossref","first-page":"6405","DOI":"10.1158\/0008-5472.CAN-06-0854","article-title":"Association of antigen-processing machinery and HLA antigen phenotype of melanoma cells with survival in American joint committee on cancer stage III and IV melanoma patients","volume":"66","author":"Anichini","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/bs.enz.2017.08.006_bb0155","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s00262-011-1137-9","article-title":"Expression of antigen processing and presenting molecules in brain metastasis of breast cancer","volume":"61","author":"Liu","year":"2012","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/bs.enz.2017.08.006_bb0160","doi-asserted-by":"crossref","first-page":"6418","DOI":"10.1158\/0008-5472.CAN-05-0044","article-title":"Immunoselective pressure and human leukocyte antigen class I antigen machinery defects in microsatellite unstable colorectal cancers","volume":"65","author":"Kloor","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/bs.enz.2017.08.006_bb0165","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/ijc.11681","article-title":"MHC class I antigen processing pathway defects, ras mutations and disease stage in colorectal carcinoma","volume":"109","author":"Atkins","year":"2004","journal-title":"Int. J. Cancer"},{"key":"10.1016\/bs.enz.2017.08.006_bb0170","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1471-2407-7-33","article-title":"HNPCC versus sporadic microsatellite-unstable colon cancers follow different routes toward loss of HLA class I expression","volume":"7","author":"Dierssen","year":"2007","journal-title":"BMC Cancer"},{"key":"10.1016\/bs.enz.2017.08.006_bb0175","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s00262-009-0765-9","article-title":"Relationship between HLA class I antigen processing machinery component expression and the clinicopathologic characteristics of bladder carcinomas","volume":"59","author":"Cathro","year":"2010","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/bs.enz.2017.08.006_bb0180","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/ijc.20499","article-title":"Coordinated down regulation of the antigen presentation machinery and HLA class I\/beta2-microglobulin complex is responsible for HLA-ABC loss in bladder cancer","volume":"113","author":"Romero","year":"2005","journal-title":"Int. J. Cancer"},{"key":"10.1016\/bs.enz.2017.08.006_bb0185","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1158\/1078-0432.CCR-04-2146","article-title":"Defects in the human leukocyte antigen class I antigen processing machinery in head and neck squamous cell carcinoma: association with clinical outcome","volume":"11","author":"Meissner","year":"2005","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/bs.enz.2017.08.006_bb0190","doi-asserted-by":"crossref","first-page":"9281","DOI":"10.1158\/0008-5472.CAN-06-0488","article-title":"HLA class I antigen down-regulation in primary laryngeal squamous cell carcinoma lesions as a poor prognostic marker","volume":"66","author":"Ogino","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/bs.enz.2017.08.006_bb0195","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1097\/01.ju.0000094807.95420.fe","article-title":"Down-regulation of HLA class I antigen processing molecules: an immune escape mechanism of renal cell carcinoma?","volume":"171","author":"Atkins","year":"2004","journal-title":"J. Urol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0200","first-page":"1721","article-title":"Characterization of human lymphocyte antigen class I antigen-processing machinery defects in renal cell carcinoma lesions with special emphasis on transporter-associated with antigen-processing down-regulation","volume":"9","author":"Seliger","year":"2003","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/bs.enz.2017.08.006_bb0205","first-page":"1625","article-title":"Expression of HLA class I antigen and proteasome subunits LMP-2 and LMP-10 in primary vs. metastatic breast carcinoma lesions","volume":"25","author":"Gobbi","year":"2004","journal-title":"Int. J. Oncol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0210","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00262-009-0769-5","article-title":"Association of HLA class I antigen abnormalities with disease progression and early recurrence in prostate cancer","volume":"59","author":"Seliger","year":"2010","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/bs.enz.2017.08.006_bb0215","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.ygyno.2008.12.030","article-title":"Down-regulation of proteasomal subunit MB1 is an independent predictor of improved survival in ovarian cancer","volume":"113","author":"Leffers","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0220","doi-asserted-by":"crossref","first-page":"5471","DOI":"10.1158\/0008-5472.CAN-06-4735","article-title":"Expression and functional analysis of human leukocyte antigen class I antigen-processing machinery in medulloblastoma","volume":"67","author":"Raffaghello","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/bs.enz.2017.08.006_bb0225","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0002-9440(10)65321-7","article-title":"Down-regulation of HLA class I antigen-processing molecules in malignant melanoma: association with disease progression","volume":"154","author":"Kageshita","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0230","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3892\/or_00000717","article-title":"HLA class I antigen and transporter associated with antigen processing down regulation in metastatic lesions of head and neck squamous cell carcinoma as a marker of poor prognosis","volume":"23","author":"Bandoh","year":"2010","journal-title":"Oncol. Rep."},{"key":"10.1016\/bs.enz.2017.08.006_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012424","article-title":"Trastuzumab mediated T-cell response against HER-2\/neu overexpressing esophageal adenocarcinoma depends on intact antigen processing machinery","volume":"5","author":"Milano","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/bs.enz.2017.08.006_bb0240","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.ygyno.2003.11.037","article-title":"Mutations in TAP genes are common in cervical carcinomas","volume":"92","author":"Fowler","year":"2004","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0245","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1080\/00365520902998679","article-title":"Down-regulation of HLA class I antigen-processing machinery components in esophageal squamous cell carcinomas: association with disease progression","volume":"44","author":"Liu","year":"2009","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0250","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/leu.2008.391","article-title":"In situ analysis of the antigen-processing machinery in acute myeloid leukaemic blasts by tissue microarray","volume":"23","author":"Hoves","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/bs.enz.2017.08.006_bb0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044952","article-title":"Post-transcriptional and epigenetic regulation of antigen processing machinery (APM) components and HLA-I in cervical cancers from Uighur women","volume":"7","author":"Hasim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/bs.enz.2017.08.006_bb0260","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00008390-200306000-00005","article-title":"Association of TAP1 downregulation in human primary melanoma lesions with lack of spontaneous regression","volume":"13","author":"Dissemond","year":"2003","journal-title":"Melanoma Res."},{"key":"10.1016\/bs.enz.2017.08.006_bb0265","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1084\/jem.177.2.265","article-title":"Identification of human cancers deficient in antigen processing","volume":"177","author":"Restifo","year":"1993","journal-title":"J. Exp. Med."},{"key":"10.1016\/bs.enz.2017.08.006_bb0270","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1034\/j.1399-0039.2001.057001039.x","article-title":"Downregulation of the constitutive tapasin expression in human tumor cells of distinct origin and its transcriptional upregulation by cytokines","volume":"57","author":"Seliger","year":"2001","journal-title":"Tissue Antigens"},{"key":"10.1016\/bs.enz.2017.08.006_bb0275","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2016.1274476","article-title":"Loss of tapasin in human lung and colon cancer cells and escape from tumor-associated antigen-specific CTL recognition","volume":"6","author":"Shionoya","year":"2017","journal-title":"Oncoimmunology"},{"key":"10.1016\/bs.enz.2017.08.006_bb0280","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1186\/s12967-015-0647-1","article-title":"Loss of tapasin correlates with diminished CD8(+) T-cell immunity and prognosis in colorectal cancer","volume":"13","author":"Sokol","year":"2015","journal-title":"J. Transl. Med."},{"key":"10.1016\/bs.enz.2017.08.006_bb0285","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.coi.2015.12.007","article-title":"The urgent need to recover MHC class I in cancers for effective immunotherapy","volume":"39","author":"Garrido","year":"2016","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0290","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/pbc.25842","article-title":"Characterization of MHC class I and beta-2-microglobulin expression in pediatric solid malignancies to guide selection of immune-based therapeutic trials","volume":"63","author":"Haworth","year":"2016","journal-title":"Pediatr. Blood Cancer"},{"key":"10.1016\/bs.enz.2017.08.006_bb0295","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1479-5876-3-11","article-title":"HLA class I and II genotype of the NCI-60 cell lines","volume":"3","author":"Adams","year":"2005","journal-title":"J. Transl. Med."},{"key":"10.1016\/bs.enz.2017.08.006_bb0300","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.4049\/jimmunol.157.5.1823","article-title":"Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules?","volume":"157","author":"Yewdell","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0305","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.it.2006.06.008","article-title":"The DRiP hypothesis decennial: support, controversy, refinement and extension","volume":"27","author":"Yewdell","year":"2006","journal-title":"Trends Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0310","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1242\/jcs.114.5.845","article-title":"At the crossroads of cell biology and immunology: DRiPs and other sources of peptide ligands for MHC class I molecules","volume":"114","author":"Yewdell","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/bs.enz.2017.08.006_bb0315","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.molcel.2013.03.010","article-title":"Principles of cotranslational ubiquitination and quality control at the ribosome","volume":"50","author":"Duttler","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.enz.2017.08.006_bb0320","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.molcel.2013.03.009","article-title":"A cotranslational ubiquitination pathway for quality control of misfolded proteins","volume":"50","author":"Wang","year":"2013","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.enz.2017.08.006_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067796","article-title":"MHC class I antigen presentation of DRiP-derived peptides from a model antigen is not dependent on the AAA ATPase p 97","volume":"8","author":"Palmer","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/bs.enz.2017.08.006_bb0330","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2011.10.002","article-title":"Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes","volume":"147","author":"Ingolia","year":"2011","journal-title":"Cell"},{"key":"10.1016\/bs.enz.2017.08.006_bb0335","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M113.482570","article-title":"The ATP costs and time required to degrade ubiquitinated proteins by the 26 S proteasome","volume":"288","author":"Peth","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.enz.2017.08.006_bb0340","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1189\/jlb.1113599","article-title":"Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors","volume":"95","author":"Anton","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0345","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1074-7613(03)00051-7","article-title":"Quantitating protein synthesis, degradation, and endogenous antigen processing","volume":"18","author":"Princiotta","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/bs.enz.2017.08.006_bb0350","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.it.2014.01.002","article-title":"Re-examining class-I presentation and the DRiP hypothesis","volume":"35","author":"Rock","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0355","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.4049\/jimmunol.1003096","article-title":"Distinct pathways generate peptides from defective ribosomal products for CD8+ T cell immunosurveillance","volume":"186","author":"Dolan","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0360","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.molimm.2011.01.006","article-title":"Signal peptides and trans'membrane regions are broadly immunogenic and have high CD8+ T cell epitope densities: implications for vaccine development","volume":"48","author":"Kovjazin","year":"2011","journal-title":"Mol. Immunol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0365","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1155\/2001\/184856","article-title":"Alternative spliced transcripts as cancer markers","volume":"17","author":"Caballero","year":"2001","journal-title":"Dis. Markers"},{"key":"10.1016\/bs.enz.2017.08.006_bb0370","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1365-2141.2012.09158.x","article-title":"Defects in spliceosomal machinery: a new pathway of leukaemogenesis","volume":"158","author":"Maciejewski","year":"2012","journal-title":"Br. J. Haematol."},{"key":"10.1016\/bs.enz.2017.08.006_bb0375","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.1158\/1078-0432.CCR-12-1182","article-title":"Mutated BCR-ABL generates immunogenic T-cell epitopes in CML patients","volume":"18","author":"Cai","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/bs.enz.2017.08.006_bb0380","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/CJI.0b013e3182562d37","article-title":"Immunologic evaluation of peptides derived from BCR\/ABL-out-of-frame fusion protein in HLA A2.1 transgenic mice","volume":"35","author":"Casnici","year":"2012","journal-title":"J. Immunother."},{"key":"10.1016\/bs.enz.2017.08.006_bb0385","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/nature05874","article-title":"Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project","volume":"447","author":"Birney","year":"2007","journal-title":"Nature"},{"key":"10.1016\/bs.enz.2017.08.006_bb0390","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00262-011-1032-4","article-title":"CTL recognition of a novel HLA-A*0201-binding peptide derived from glioblastoma multiforme tumor cells","volume":"60","author":"Myers","year":"2011","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/bs.enz.2017.08.006_bb0395","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res."},{"key":"10.1016\/bs.enz.2017.08.006_bb0400","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s002510050595","article-title":"SYFPEITHI: database for MHC ligands and peptide motifs","volume":"50","author":"Rammensee","year":"1999","journal-title":"Immunogenetics"},{"key":"10.1016\/bs.enz.2017.08.006_bb0405","doi-asserted-by":"crossref","DOI":"10.18632\/oncotarget.10923","article-title":"IRES-dependent translation of the long non coding RNA meloe in melanoma cells produces the most immunogenic MELOE antigens","volume":"7","author":"Charpentier","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/bs.enz.2017.08.006_bb0410","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/bs.enz.2017.08.006_bb0415","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/bs.enz.2017.08.006_bb0420","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.phrs.2017.03.012","article-title":"Mechanistic and pharmacologic insights on immune checkpoint inhibitors","volume":"120","author":"Sweis","year":"2017","journal-title":"Pharmacol. Res."}],"container-title":["The Enzymes","Peptidomics of Cancer-Derived Enzyme Products"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874604717300252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1874604717300252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:11:06Z","timestamp":1761743466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1874604717300252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9780128126387"],"references-count":83,"URL":"https:\/\/doi.org\/10.1016\/bs.enz.2017.08.006","relation":{},"ISSN":["1874-6047"],"issn-type":[{"type":"print","value":"1874-6047"}],"subject":[],"published":{"date-parts":[[2017]]}}}