{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:36:06Z","timestamp":1776375366534,"version":"3.51.2"},"reference-count":205,"publisher":"Elsevier","isbn-type":[{"value":"9780128047071","type":"print"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1016\/bs.ircmb.2015.09.003","type":"book-chapter","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T01:59:36Z","timestamp":1446602376000},"page":"259-297","source":"Crossref","is-referenced-by-count":21,"title":["Cell-Nonautonomous Mechanisms Underlying Cellular and Organismal Aging"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.ircmb.2015.09.003_bib0005","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1038\/nrm2938","article-title":"Heat shock factors: integrators of cell stress, development and lifespan","volume":"11","author":"Akerfelt","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0010","doi-asserted-by":"crossref","first-page":"4949","DOI":"10.1128\/MCB.18.9.4949","article-title":"HSP90 interacts with and regulates the activity of heat shock factor 1 in Xenopus oocytes","volume":"18","author":"Ali","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0015","doi-asserted-by":"crossref","first-page":"164","DOI":"10.15698\/mic2014.06.152","article-title":"Cell-autonomous mechanisms of chronological aging in the yeast Saccharomyces cerevisiae","volume":"1","author":"Arlia-Ciommo","year":"2014","journal-title":"Microb. Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0020","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.4161\/15384101.2014.965063","article-title":"Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan","volume":"13","author":"Arlia-Ciommo","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0025","doi-asserted-by":"crossref","first-page":"16522","DOI":"10.3390\/ijms150916522","article-title":"Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid","volume":"15","author":"Arlia-Ciommo","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0030","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3389\/fphys.2012.00283","article-title":"Integration of peroxisomes into an endomembrane system that governs cellular aging","volume":"3","author":"Beach","year":"2012","journal-title":"Front. Physiol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0035","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.3390\/ijms16035528","article-title":"Mechanisms by which different functional states of mitochondria define yeast longevity","volume":"16","author":"Beach","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0040","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1080\/15384101.2015.1026493","article-title":"Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome","volume":"14","author":"Beach","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0045","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/978-94-007-6889-5_9","article-title":"Essential roles of peroxisomally produced and metabolized biomolecules in regulating yeast longevity","volume":"69","author":"Beach","year":"2013","journal-title":"Subcell. Biochem."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0050","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.4161\/cc.10.18.16947","article-title":"In search of housekeeping pathways that regulate longevity","volume":"10","author":"Beach","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0055","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.cell.2007.03.024","article-title":"Nicotinamide riboside promotes Sir2 silencing and extends lifespan via Nrk and Urh1\/Pnp1\/Meu1 pathways to NAD+","volume":"129","author":"Belenky","year":"2007","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0060","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.exger.2014.02.002","article-title":"The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation?","volume":"56","author":"Bennett","year":"2014","journal-title":"Exp. Gerontol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0065","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1038\/ncomms4483","article-title":"Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans","volume":"5","author":"Bennett","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0070","doi-asserted-by":"crossref","first-page":"14914","DOI":"10.1073\/pnas.0902882106","article-title":"Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging","volume":"106","author":"Ben-Zvi","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0075","doi-asserted-by":"crossref","first-page":"11718","DOI":"10.1523\/JNEUROSCI.1098-11.2011","article-title":"Degeneracy and neuromodulation among thermosensory neurons contribute to robust thermosensory behaviors in Caenorhabditis elegans","volume":"31","author":"Beverly","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0080","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/bph.12869","article-title":"Hydrogen sulfide: physiological properties and therapeutic potential in ischaemia","volume":"172","author":"Bos","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1146\/annurev-biochem-062209-093836","article-title":"Protein folding and modification in the mammalian endoplasmic reticulum","volume":"80","author":"Braakman","year":"2011","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0090","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0095","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.4161\/cc.8.14.8852","article-title":"Acetic acid effects on aging in budding yeast: are they relevant to aging in higher eukaryotes?","volume":"8","author":"Burhans","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0100","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.4161\/cc.8.8.8287","article-title":"A molecular mechanism of chronological aging in yeast","volume":"8","author":"Burtner","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0105","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.4161\/cc.10.9.15464","article-title":"A genomic analysis of chronological longevity factors in budding yeast","volume":"10","author":"Burtner","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0110","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.cell.2013.02.035","article-title":"Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism","volume":"153","author":"Cabreiro","year":"2013","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0115","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/emmm.201100972","article-title":"Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans","volume":"5","author":"Cabreiro","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0120","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.taap.2007.02.015","article-title":"Biological stress response terminology: integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework","volume":"222","author":"Calabrese","year":"2007","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0125","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s12079-011-0119-1","article-title":"Hormesis provides a generalized quantitative estimate of biological plasticity","volume":"5","author":"Calabrese","year":"2011","journal-title":"J. Cell Commun. Signal."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0130","doi-asserted-by":"crossref","first-page":"R622","DOI":"10.1016\/j.cub.2012.07.004","article-title":"Unfolded protein response","volume":"22","author":"Cao","year":"2012","journal-title":"Curr. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0135","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.molcel.2012.04.001","article-title":"Cell differentiation within a yeast colony: metabolic and regulatory parallels with a tumor-affected organism","volume":"46","author":"C\u00e1p","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0140","doi-asserted-by":"crossref","first-page":"32572","DOI":"10.1074\/jbc.M109.022871","article-title":"Yeast colony survival depends on metabolic adaptation and cell differentiation rather than on stress defense","volume":"284","author":"C\u00e1p","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0145","doi-asserted-by":"crossref","first-page":"976753","DOI":"10.1155\/2012\/976753","article-title":"Reactive oxygen species in the signaling and adaptation of multicellular microbial communities","volume":"2012","author":"C\u00e1p","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0150","doi-asserted-by":"crossref","first-page":"e1000486","DOI":"10.1371\/journal.pgen.1000486","article-title":"HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans","volume":"5","author":"Chen","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0155","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.tcb.2013.06.005","article-title":"IRE1: ER stress sensor and cell fate executor","volume":"23","author":"Chen","year":"2013","journal-title":"Trends Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0160","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1016\/j.celrep.2014.10.032","article-title":"Bacterial metabolite indole modulates incretin secretion from intestinal enteroendocrine L cells","volume":"9","author":"Chimerel","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0165","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/nrg3182","article-title":"The human microbiome: at the interface of health and disease","volume":"13","author":"Cho","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0170","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/cmi.12234","article-title":"Commensals, probiotics and pathogens in the Caenorhabditis elegans model","volume":"16","author":"Clark","year":"2014","journal-title":"Cell Microbiol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0175","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.cell.2012.01.035","article-title":"The impact of the gut microbiota on human health: an integrative view","volume":"148","author":"Clemente","year":"2012","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0180","doi-asserted-by":"crossref","first-page":"e1000503","DOI":"10.1371\/journal.pgen.1000503","article-title":"Caenorhabditis elegans genomic response to soil bacteria predicts environment-specific genetic effects on life history traits","volume":"5","author":"Coolon","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0185","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1016\/j.cell.2014.05.031","article-title":"The search for antiaging interventions: from elixirs to fasting regimens","volume":"157","author":"de Cabo","year":"2014","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0190","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.18632\/aging.100406","article-title":"Chronological lifespan in stationary culture: from yeast to human cells","volume":"3","author":"Demidenko","year":"2011","journal-title":"Aging"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0195","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/1574-6976.12060","article-title":"Budding yeast as a model organism to study the effects of age","volume":"38","author":"Denoth Lippuner","year":"2014","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0200","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.tim.2015.03.002","article-title":"Fate, activity, and impact of ingested bacteria within the human gut microbiota","volume":"23","author":"Derrien","year":"2015","journal-title":"Trends Microbiol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0205","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ceb.2013.12.003","article-title":"The good and the bad of being connected: the integrons of aging","volume":"26","author":"Dillin","year":"2014","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0210","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1126\/science.1077780","article-title":"Rates of behavior and aging specified by mitochondrial function during development","volume":"298","author":"Dillin","year":"2002","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0215","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fgene.2015.00080","article-title":"Proteostasis collapse, inter-tissue communication, and the regulation of aging at the organismal level","volume":"6","author":"Dubnikov","year":"2015","journal-title":"Front. Genet."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0220","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1534\/g3.112.005116","article-title":"Influence of steroid hormone signaling on life span control by Caenorhabditis elegans insulin-like signaling","volume":"3","author":"Dumas","year":"2013","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0225","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cell.2010.12.016","article-title":"The cell-non-autonomous nature of electron transport chain-mediated longevity","volume":"144","author":"Durieux","year":"2011","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0230","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.cmet.2014.02.010","article-title":"Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme A stimulates autophagy and prolongs lifespan","volume":"19","author":"Eisenberg","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0235","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.cell.2005.08.042","article-title":"Sir2 blocks extreme life-span extension","volume":"123","author":"Fabrizio","year":"2005","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0240","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-1-59745-361-5_8","article-title":"The chronological life span of Saccharomyces cerevisiae","volume":"371","author":"Fabrizio","year":"2007","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0245","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.18632\/aging.100412","article-title":"Conserved role of medium acidification in chronological senescence of yeast and mammalian cells","volume":"3","author":"Fabrizio","year":"2011","journal-title":"Aging"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0250","doi-asserted-by":"crossref","first-page":"R965","DOI":"10.1016\/j.cub.2010.09.050","article-title":"The natural history of Caenorhabditis elegans","volume":"20","author":"F\u00e9lix","year":"2010","journal-title":"Curr. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0255","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1741-7007-10-59","article-title":"Population dynamics and habitat sharing of natural populations of Caenorhabditis elegans and C. briggsae","volume":"10","author":"F\u00e9lix","year":"2012","journal-title":"BMC Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0260","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cell.2015.02.020","article-title":"Promoting health and longevity through diet: from model organisms to humans","volume":"161","author":"Fontana","year":"2015","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0265","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.1172539","article-title":"Extending healthy life span\u2014from yeast to humans","volume":"328","author":"Fontana","year":"2010","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0270","series-title":"Yeast Intermediary Metabolism","author":"Fraenkel","year":"2011"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0275","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1101\/gad.1575307","article-title":"Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells","volume":"21","author":"Garcia","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0280","doi-asserted-by":"crossref","first-page":"a013169","DOI":"10.1101\/cshperspect.a013169","article-title":"Endoplasmic reticulum stress sensing in the unfolded protein response","volume":"5","author":"Gardner","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0285","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1093\/genetics\/161.3.1101","article-title":"Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation","volume":"161","author":"Garigan","year":"2002","journal-title":"Genetics"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0290","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.aaa4972","article-title":"Cancer and the microbiota","volume":"348","author":"Garrett","year":"2015","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0295","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1093\/genetics\/154.4.1597","article-title":"Genetic, behavioral and environmental determinants of male longevity in Caenorhabditis elegans","volume":"154","author":"Gems","year":"2000","journal-title":"Genetics"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0300","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fmicb.2013.00033","article-title":"Molecular mechanisms of Saccharomyces cerevisiae stress adaptation and programmed cell death in response to acetic acid","volume":"4","author":"Giannattasio","year":"2013","journal-title":"Front. Microbiol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0305","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.exger.2009.06.001","article-title":"Effect of calorie restriction on the metabolic history of chronologically aging yeast","volume":"44","author":"Goldberg","year":"2009","journal-title":"Exp. Gerontol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0310","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1042\/BST0371050","article-title":"A novel function of lipid droplets in regulating longevity","volume":"37","author":"Goldberg","year":"2009","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0315","doi-asserted-by":"crossref","first-page":"393","DOI":"10.18632\/aging.100168","article-title":"Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes","volume":"2","author":"Goldberg","year":"2010","journal-title":"Aging"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0320","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1186\/1471-2180-12-300","article-title":"Delayed accumulation of intestinal coliform bacteria enhances life span and stress resistance in Caenorhabditis elegans fed respiratory deficient E. coli","volume":"12","author":"Gomez","year":"2012","journal-title":"BMC Microbiol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0325","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1073\/pnas.1116053109","article-title":"Metagenomic systems biology of the human gut microbiome reveals topological shifts associated with obesity and inflammatory bowel disease","volume":"109","author":"Greenblum","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0330","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2014.08.041","article-title":"Aging research\u2014where do we stand and where are we going?","volume":"159","author":"Guarente","year":"2014","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0335","doi-asserted-by":"crossref","first-page":"e1003466","DOI":"10.1371\/journal.pgen.1003466","article-title":"Identification of a tissue-selective heat shock response regulatory network","volume":"9","author":"Guisbert","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0340","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.cell.2012.12.043","article-title":"Bacterial nitric oxide extends the lifespan of C. elegans","volume":"152","author":"Gusarov","year":"2013","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0345","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.tcb.2013.02.002","article-title":"Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond","volume":"23","author":"Haynes","year":"2013","journal-title":"Trends Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0350","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.devcel.2007.07.016","article-title":"ClpP mediates activation of a mitochondrial unfolded protein response in C. elegans","volume":"13","author":"Haynes","year":"2007","journal-title":"Dev. Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0355","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1242\/jcs.075119","article-title":"The mitochondrial UPR\u2014protecting organelle protein homeostasis","volume":"123","author":"Haynes","year":"2010","journal-title":"J. Cell Sci."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0360","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.molcel.2010.01.015","article-title":"The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans","volume":"37","author":"Haynes","year":"2010","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0365","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cell.2014.01.025","article-title":"You are what you host: microbiome modulation of the aging process","volume":"156","author":"Heintz","year":"2014","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0370","doi-asserted-by":"crossref","first-page":"9730","DOI":"10.1073\/pnas.1002575107","article-title":"Insulin\/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity","volume":"107","author":"Henis-Korenblit","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0375","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nature01135","article-title":"Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans","volume":"419","author":"Herndon","year":"2002","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0380","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0385","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2014.11.048","article-title":"Endogenous hydrogen sulfide production is essential for dietary restriction benefits","volume":"160","author":"Hine","year":"2015","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0390","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.exger.2014.12.010","article-title":"Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway","volume":"68","author":"Hine","year":"2014","journal-title":"Exp. Gerontol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0395","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.tcb.2014.05.003","article-title":"Proteostasis impairment in protein-misfolding and -aggregation diseases","volume":"24","author":"Hipp","year":"2014","journal-title":"Trends Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0400","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1523\/JNEUROSCI.18-06-02084.1998","article-title":"Control of neural development and function in a thermoregulatory network by the LIM homeobox gene lin-11","volume":"18","author":"Hobert","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0405","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.cmet.2012.10.007","article-title":"Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk","volume":"16","author":"Holmes","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0410","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature12188","article-title":"Mitonuclear protein imbalance as a conserved longevity mechanism","volume":"497","author":"Houtkooper","year":"2013","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0415","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/978-1-62703-239-1_30","article-title":"Assessing chronological aging in Saccharomyces cerevisiae","volume":"965","author":"Hu","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0420","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/acel.12202","article-title":"Tor-Sch9 deficiency activates catabolism of the ketone body-like acetic acid to promote trehalose accumulation and longevity","volume":"13","author":"Hu","year":"2014","journal-title":"Aging Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0425","first-page":"1","article-title":"Expanding proteostasis by membrane trafficking networks","volume":"3","author":"Hutt","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0435","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.ceb.2014.12.003","article-title":"The mitochondrial unfolded protein response-synchronizing genomes","volume":"33","author":"Jovaisaite","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0440","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1242\/jeb.090738","article-title":"The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease","volume":"217","author":"Jovaisaite","year":"2014","journal-title":"J. Exp. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0445","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1172\/JCI76308","article-title":"Emerging roles of gut microbiota and the immune system in the development of the enteric nervous system","volume":"125","author":"Kabouridis","year":"2015","journal-title":"J. Clin. Invest."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0450","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature08981","article-title":"Lessons on longevity from budding yeast","volume":"464","author":"Kaeberlein","year":"2010","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0455","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4161\/cc.11.2.18959","article-title":"A new chronological survival assay in mammalian cell culture","volume":"11","author":"Kaeberlein","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0460","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2013.06.046","article-title":"Aging: seeking mitonuclear balance","volume":"154","author":"Karpac","year":"2013","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0465","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/nature10213","article-title":"Human nutrition, the gut microbiome and the immune system","volume":"474","author":"Kau","year":"2011","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0470","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nm.3014","article-title":"Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine","volume":"19","author":"Kim","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0475","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-biochem-060208-092442","article-title":"Molecular chaperone functions in protein folding and proteostasis","volume":"82","author":"Kim","year":"2013","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0480","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.niox.2014.01.002","article-title":"The physiological role of hydrogen sulfide and beyond","volume":"41","author":"Kimura","year":"2014","journal-title":"Nitric Oxide"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0485","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1146\/annurev-biochem-060614-033955","article-title":"The biology of proteostasis in aging and disease","volume":"84","author":"Labbadia","year":"2015","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0490","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1126\/science.1064653","article-title":"Extension of life-span in Caenorhabditis elegans by a diet lacking coenzyme Q","volume":"295","author":"Larsen","year":"2002","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0495","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/acel.12277","article-title":"Effects of nutritional components on aging","volume":"14","author":"Lee","year":"2015","journal-title":"Aging Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0500","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.cub.2009.03.041","article-title":"Regulation of the longevity response to temperature by thermosensory neurons in Caenorhabditis elegans","volume":"19","author":"Lee","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0505","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng1056","article-title":"A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity","volume":"33","author":"Lee","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0510","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nchembio.1535","article-title":"Gut microbiota-generated metabolites in animal health and disease","volume":"10","author":"Lee","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0515","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/acel.12113","article-title":"The significance of peroxisome function in chronological aging of Saccharomyces cerevisiae","volume":"12","author":"Lefevre","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0520","doi-asserted-by":"crossref","first-page":"6544","DOI":"10.3390\/molecules20046544","article-title":"Longevity extension by phytochemicals","volume":"20","author":"Leonov","year":"2015","journal-title":"Molecules"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0525","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/iub.1183","article-title":"A network of interorganellar communications underlies cellular aging","volume":"65","author":"Leonov","year":"2013","journal-title":"IUBMB Life"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0530","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.18632\/aging.100402","article-title":"Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression","volume":"3","author":"Leontieva","year":"2011","journal-title":"Aging"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0535","doi-asserted-by":"crossref","first-page":"12804","DOI":"10.1073\/pnas.1300926110","article-title":"Metabolic modeling of species interaction in the human microbiome elucidates community-level assembly rules","volume":"110","author":"Levy","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0540","doi-asserted-by":"crossref","first-page":"a004507","DOI":"10.1101\/cshperspect.a004507","article-title":"Chemical and biological approaches for adapting proteostasis to ameliorate protein misfolding and aggregation diseases: progress and prognosis","volume":"3","author":"Lindquist","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0545","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/ncomms2071","article-title":"Escherichia coli noncoding RNAs can affect gene expression and physiology of Caenorhabditis elegans","volume":"3","author":"Liu","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0550","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cmet.2012.06.002","article-title":"Replicative and chronological aging in Saccharomyces cerevisiae","volume":"16","author":"Longo","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0555","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0560","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1159\/000332966","article-title":"Metagenomics: key to human gut microbiota","volume":"29","author":"Maccaferri","year":"2011","journal-title":"Dig. Dis."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0565","doi-asserted-by":"crossref","first-page":"e26454","DOI":"10.4161\/worm.26454","article-title":"Food, pathogen, signal: the multifaceted nature of a bacterial diet","volume":"2","author":"MacNeil","year":"2013","journal-title":"Worm"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0570","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.cell.2013.02.049","article-title":"Diet-induced developmental acceleration independent of TOR and insulin in C. elegans","volume":"153","author":"MacNeil","year":"2013","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0575","doi-asserted-by":"crossref","first-page":"6102","DOI":"10.1523\/JNEUROSCI.4023-12.2013","article-title":"A neuronal GPCR is critical for the induction of the heat shock response in the nematode C. elegans","volume":"33","author":"Maman","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0580","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.cmet.2014.07.009","article-title":"Cell-nonautonomous control of the UPR: mastering energy homeostasis","volume":"20","author":"Mardones","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0585","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.molcel.2014.01.016","article-title":"Regulation of autophagy by cytosolic acetyl-coenzyme A","volume":"53","author":"Mari\u00f1o","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0590","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/j.1474-9726.2011.00713.x","article-title":"Loss of intestinal nuclei and intestinal integrity in aging C. elegans","volume":"10","author":"McGee","year":"2011","journal-title":"Aging Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0595","doi-asserted-by":"crossref","first-page":"e1002338","DOI":"10.1371\/journal.pcbi.1002338","article-title":"Macro-level modeling of the response of C. elegans reproduction to chronic heat stress","volume":"8","author":"McMullen","year":"2012","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0600","doi-asserted-by":"crossref","first-page":"e1002048","DOI":"10.1371\/journal.pbio.1002048","article-title":"Calorie restriction-mediated replicative lifespan extension in yeast is non-cell autonomous","volume":"13","author":"Mei","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0605","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1128\/IAI.00653-12","article-title":"Association with soil bacteria enhances p38-dependent infection resistance in Caenorhabditis elegans","volume":"81","author":"Montalvo-Katz","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0610","doi-asserted-by":"crossref","first-page":"R363","DOI":"10.1016\/j.cub.2009.03.040","article-title":"Aging: shall we take the high road?","volume":"19","author":"Mori","year":"2009","journal-title":"Curr. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0615","doi-asserted-by":"crossref","first-page":"3788","DOI":"10.1101\/gad.12.24.3788","article-title":"Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulators","volume":"12","author":"Morimoto","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0620","series-title":"Protein Homeostasis","author":"Morimoto","year":"2012"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0625","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s00335-014-9525-z","article-title":"The mitochondrial unfolded protein response in mammalian physiology","volume":"25","author":"Mottis","year":"2014","journal-title":"Mamm. Genome"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0630","doi-asserted-by":"crossref","first-page":"e24530","DOI":"10.1371\/journal.pone.0024530","article-title":"Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast","volume":"6","author":"Mouchiroud","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0635","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.4161\/cc.21465","article-title":"pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast","volume":"11","author":"Murakami","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0640","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.molcel.2015.02.008","article-title":"Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPRmt","volume":"58","author":"Nargund","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0645","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1223560","article-title":"Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation","volume":"337","author":"Nargund","year":"2012","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0650","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1126\/science.1223813","article-title":"Host-gut microbiota metabolic interactions","volume":"336","author":"Nicholson","year":"2012","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0655","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1242\/dmm.013011","article-title":"Caenorhabditis elegans as a model system for studying non-cell-autonomous mechanisms in protein-misfolding diseases","volume":"7","author":"Nussbaum-Krammer","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0660","doi-asserted-by":"crossref","first-page":"e8758","DOI":"10.1371\/journal.pone.0008758","article-title":"Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via AMPK, LKB1, and SKN-1","volume":"5","author":"Onken","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0665","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.cell.2013.09.021","article-title":"Muscle mitohormesis promotes longevity via systemic repression of insulin signaling","volume":"155","author":"Owusu-Ansah","year":"2013","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0670","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1042\/BJ20120312","article-title":"The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies","volume":"454","author":"Paiva","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0675","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1091\/mbc.e01-12-0149","article-title":"Ammonia pulses and metabolic oscillations guide yeast colony development","volume":"13","author":"Palkov\u00e1","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0680","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1242\/jcs.113.11.1923","article-title":"Yeast colonies synchronise their growth and development","volume":"113","author":"Palkov\u00e1","year":"2000","journal-title":"J. Cell Sci."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0685","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1038\/37398","article-title":"Ammonia mediates communication between yeast colonies","volume":"390","author":"Palkov\u00e1","year":"1997","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0690","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1574-6976.2006.00034.x","article-title":"Life within a community: benefit to yeast long-term survival","volume":"30","author":"Palkov\u00e1","year":"2006","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0695","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/1567-1364.12103","article-title":"Aging and differentiation in yeast populations: elders with different properties and functions","volume":"14","author":"Palkov\u00e1","year":"2014","journal-title":"FEMS Yeast Res."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0700","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.bbamcr.2012.02.019","article-title":"Signaling the mitochondrial unfolded protein response","volume":"1833","author":"Pellegrino","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0705","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-011811-132421","article-title":"Human microbiome in health and disease","volume":"7","author":"Pflughoeft","year":"2012","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0710","first-page":"56","article-title":"The intricate interplay between mechanisms underlying aging and cancer","volume":"6","author":"Piano","year":"2014","journal-title":"Aging Dis."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0715","doi-asserted-by":"crossref","first-page":"e1002131","DOI":"10.1371\/journal.pbio.1002131","article-title":"Why is aging conserved and what can we do about it?","volume":"13","author":"Pitt","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0720","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/CIRCRESAHA.114.300505","article-title":"Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease","volume":"114","author":"Polhemus","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0725","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1128\/IAI.05522-11","article-title":"Competition and resilience between founder and introduced bacteria in the Caenorhabditis elegans gut","volume":"80","author":"Portal-Celhay","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0730","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2180-12-49","article-title":"Control of intestinal bacterial proliferation in regulation of lifespan in Caenorhabditis elegans","volume":"12","author":"Portal-Celhay","year":"2012","journal-title":"BMC Microbiol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0735","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nrm3542","article-title":"Diversity in the origins of proteostasis networks\u2014a driver for protein function in evolution","volume":"14","author":"Powers","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0740","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1126\/science.1156093","article-title":"Regulation of the cellular heat shock response in Caenorhabditis elegans by thermosensory neurons","volume":"320","author":"Prahlad","year":"2008","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0745","doi-asserted-by":"crossref","first-page":"14204","DOI":"10.1073\/pnas.1106557108","article-title":"Neuronal circuitry regulates the response of Caenorhabditis elegans to misfolded proteins","volume":"108","author":"Prahlad","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0750","doi-asserted-by":"crossref","first-page":"e80135","DOI":"10.1371\/journal.pone.0080135","article-title":"C. elegans aging is modulated by hydrogen sulfide and the sulfhydrylase\/cysteine synthase cysl-2","volume":"8","author":"Qabazard","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0755","doi-asserted-by":"crossref","first-page":"e259","DOI":"10.1371\/journal.pbio.0050259","article-title":"Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans","volume":"5","author":"Rea","year":"2007","journal-title":"PLoS Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0760","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exger.2015.03.005","article-title":"The activation of protein homeostasis protective mechanisms perhaps is not responsible for lifespan extension caused by deficiencies of mitochondrial proteins in C. elegans","volume":"65","author":"Ren","year":"2015","journal-title":"Exp. Gerontol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0765","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.arr.2012.05.003","article-title":"Organ-specific mediation of lifespan extension: more than a gut feeling?","volume":"12","author":"Rera","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0770","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.4161\/15384101.2014.965003","article-title":"Mechanism of liponecrosis, a distinct mode of programmed cell death","volume":"13","author":"Richard","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0775","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.cell.2015.03.033","article-title":"Gut microbiota: the link to your second brain","volume":"161","author":"Ridaura","year":"2015","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0780","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrm2199","article-title":"Signal integration in the endoplasmic reticulum unfolded protein response","volume":"8","author":"Ron","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0785","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nrm2234","article-title":"Endocrine regulation of ageing","volume":"8","author":"Russell","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0790","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1083\/jcb.201003138","article-title":"Regulation of basal cellular physiology by the homeostatic unfolded protein response","volume":"189","author":"Rutkowski","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0795","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1474-9726.2008.00378.x","article-title":"Altered bacterial metabolism, not coenzyme Q content, is responsible for the lifespan extension in Caenorhabditis elegans fed an Escherichia coli diet lacking coenzyme Q","volume":"7","author":"Saiki","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0800","first-page":"1392","article-title":"Activation of heat shock gene transcription by heat shock factor 1 involves oligomerization, acquisition of DNA-binding activity, and nuclear localization and can occur in the absence of stress","volume":"13","author":"Sarge","year":"1993","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0805","doi-asserted-by":"crossref","first-page":"17775","DOI":"10.1073\/pnas.0910342106","article-title":"In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles","volume":"106","author":"Schindler","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0810","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ceb.2015.01.006","article-title":"Endocrine aspects of organelle stress\u2014cell non-autonomous signaling of mitochondria and the ER","volume":"33","author":"Schinzel","year":"2015","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0815","doi-asserted-by":"crossref","first-page":"110","DOI":"10.15698\/mic2014.04.142","article-title":"Metabolites in aging and autophagy","volume":"1","author":"Schroeder","year":"2014","journal-title":"Microb. Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0820","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.cmet.2014.10.016","article-title":"Specialized metabolites from the microbiome in health and disease","volume":"20","author":"Sharon","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0825","doi-asserted-by":"crossref","first-page":"138","DOI":"10.4161\/cc.26885","article-title":"Macromitophagy, neutral lipids synthesis, and peroxisomal fatty acid oxidation protect yeast from \u201cliponecrosis\u201d, a previously unknown form of programmed cell death","volume":"13","author":"Sheibani","year":"2014","journal-title":"Cell Cycle"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0830","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mam.2012.11.001","article-title":"The gut microbiota, obesity and insulin resistance","volume":"34","author":"Shen","year":"2013","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0835","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2014.12.027","article-title":"A protein restriction-dependent sulfur code for longevity","volume":"160","author":"Shim","year":"2015","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0840","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/978-1-62703-556-9_5","article-title":"Studying the replicative life span of yeast cells","volume":"1048","author":"Sinclair","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0845","first-page":"1209","article-title":"Measuring replicative life span in the budding yeast","volume":"28","author":"Steffen","year":"2009","journal-title":"J. Vis. Exp."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0850","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.cmet.2013.05.014","article-title":"Metformin, microbes, and aging","volume":"17","author":"Storelli","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0855","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1016\/j.fgb.2010.08.005","article-title":"General factors important for the formation of structured biofilm-like yeast colonies","volume":"47","author":"St\u2019ov\u00ed\u010dek","year":"2010","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0860","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4161\/cib.18912","article-title":"Yeast biofilm colony as an orchestrated multicellular organism","volume":"5","author":"S\u0165ov\u00ed\u010dek","year":"2012","journal-title":"Commun. Integr. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0865","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/nn.2854","article-title":"Regulation of behavioral plasticity by systemic temperature signaling in Caenorhabditis elegans","volume":"14","author":"Sugi","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0870","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrm3752","article-title":"Systemic stress signalling: understanding the cell non-autonomous control of proteostasis","volume":"15","author":"Taylor","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0875","doi-asserted-by":"crossref","first-page":"a004440","DOI":"10.1101\/cshperspect.a004440","article-title":"Aging as an event of proteostasis collapse","volume":"3","author":"Taylor","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0880","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.cell.2013.05.042","article-title":"XBP-1 is a cell-nonautonomous regulator of stress resistance and longevity","volume":"153","author":"Taylor","year":"2013","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0885","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1600-0854.2010.01144.x","article-title":"Peroxisome metabolism and cellular aging","volume":"12","author":"Titorenko","year":"2011","journal-title":"Traffic"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0890","doi-asserted-by":"crossref","first-page":"e183","DOI":"10.1371\/journal.pgen.0020183","article-title":"p38 MAPK regulates expression of immune response genes and contributes to longevity in C. elegans","volume":"2","author":"Troemel","year":"2006","journal-title":"PLoS Genet."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0895","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.2174\/138161209788168182","article-title":"Studying the human gut microbiota in the trans-omics era\u2014focus on metagenomics and metabonomics","volume":"15","author":"Tuohy","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0900","doi-asserted-by":"crossref","first-page":"601836","DOI":"10.1155\/2012\/601836","article-title":"Yeast colonies: a model for studies of aging, environmental adaptation, and longevity","volume":"2012","author":"V\u00e1chov\u00e1","year":"2012","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0905","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1111\/j.1462-2920.2009.01911.x","article-title":"Architecture of developing multicellular yeast colony: spatio-temporal expression of Ato1p ammonium exporter","volume":"11","author":"V\u00e1chov\u00e1","year":"2009","journal-title":"Environ. Microbiol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0910","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1462-2920.2008.01789.x","article-title":"Metabolic diversification of cells during the development of yeast colonies","volume":"11","author":"V\u00e1chov\u00e1","year":"2009","journal-title":"Environ. Microbiol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0915","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1083\/jcb.200410064","article-title":"Physiological regulation of yeast cell death in multicellular colonies is triggered by ammonia","volume":"169","author":"V\u00e1chov\u00e1","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0920","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1042\/BST0391471","article-title":"Aging and longevity of yeast colony populations: metabolic adaptation and differentiation","volume":"39","author":"V\u00e1chov\u00e1","year":"2011","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0925","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1242\/dmm.013474","article-title":"Mechanisms of protein-folding diseases at a glance","volume":"7","author":"Valastyan","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0930","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1242\/jeb.091249","article-title":"Transcellular chaperone signaling: an organismal strategy for integrated cell stress responses","volume":"217","author":"van Oosten-Hawle","year":"2014","journal-title":"J. Exp. Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0935","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1101\/gad.241125.114","article-title":"Organismal proteostasis: role of cell-non-autonomous regulation and transcellular chaperone signaling","volume":"28","author":"van Oosten-Hawle","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0940","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1016\/j.cell.2013.05.015","article-title":"Regulation of organismal proteostasis by transcellular chaperone signaling","volume":"153","author":"van Oosten-Hawle","year":"2013","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0945","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1741-7007-10-67","article-title":"Excessive folate synthesis limits lifespan in the C. elegans:E. coli aging model","volume":"10","author":"Virk","year":"2012","journal-title":"BMC Biol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0950","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/j.1462-2920.2009.02067.x","article-title":"Role of distinct dimorphic transitions in territory colonizing and formation of yeast colony architecture","volume":"12","author":"Vop\u00e1lensk\u00e1","year":"2010","journal-title":"Environ. Microbiol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0955","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0960","doi-asserted-by":"crossref","first-page":"216","DOI":"10.12688\/f1000research.2-216.v1","article-title":"Buffering the pH of the culture medium does not extend yeast replicative lifespan","volume":"2","author":"Wasko","year":"2013","journal-title":"F1000Res"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0965","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.cell.2013.02.050","article-title":"Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response","volume":"153","author":"Watson","year":"2013","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0970","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.tem.2014.03.004","article-title":"Caenorhabditis elegans metabolic gene regulatory networks govern the cellular economy","volume":"25","author":"Watson","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0975","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cmet.2014.06.002","article-title":"Xbp1s in Pomc neurons connects ER stress with energy balance and glucose homeostasis","volume":"20","author":"Williams","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0980","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/497442a","article-title":"Ageing: beneficial miscommunication","volume":"497","author":"Wolff","year":"2013","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0985","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2014.03.007","article-title":"Differential scales of protein quality control","volume":"157","author":"Wolff","year":"2014","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0990","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cell.2010.12.023","article-title":"Mitochondrial stress signals revise an old aging theory","volume":"144","author":"Woo","year":"2011","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib0995","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.celrep.2015.04.024","article-title":"RNAi interrogation of dietary modulation of development, metabolism, behavior, and aging in C. elegans","volume":"11","author":"Xiao","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib1000","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.ijcard.2014.01.068","article-title":"Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis","volume":"172","author":"Xu","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib1005","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.cell.2015.02.047","article-title":"Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis","volume":"161","author":"Yano","year":"2015","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2015.09.003_bib1010","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.tig.2014.07.010","article-title":"Worms, bacteria, and micronutrients: an elegant model of our diet","volume":"30","author":"Yilmaz","year":"2014","journal-title":"Trends Genet."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib1015","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1242\/jcs.01275","article-title":"Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones","volume":"117","author":"Yoneda","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib1020","doi-asserted-by":"crossref","first-page":"e1002082","DOI":"10.1371\/journal.pgen.1002082","article-title":"A decline in p38 MAPK signaling underlies immunosenescence in Caenorhabditis elegans","volume":"7","author":"Youngman","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib1025","doi-asserted-by":"crossref","first-page":"621709","DOI":"10.1155\/2015\/621709","article-title":"Impact of a complex food microbiota on energy metabolism in the model organism Caenorhabditis elegans","volume":"2015","author":"Zanni","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/bs.ircmb.2015.09.003_bib1030","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0092-8674(00)81588-3","article-title":"Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1","volume":"94","author":"Zou","year":"1998","journal-title":"Cell"}],"container-title":["International Review of Cell and Molecular Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1937644815000933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1937644815000933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:27:05Z","timestamp":1761848825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1937644815000933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9780128047071"],"references-count":205,"URL":"https:\/\/doi.org\/10.1016\/bs.ircmb.2015.09.003","relation":{},"ISSN":["1937-6448"],"issn-type":[{"value":"1937-6448","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}