{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:54:47Z","timestamp":1787864087700,"version":"build-2784847793"},"reference-count":326,"publisher":"Elsevier","isbn-type":[{"value":"9780128184066","type":"print"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/bs.ircmb.2019.05.001","type":"book-chapter","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T17:45:24Z","timestamp":1560793524000},"page":"39-103","source":"Crossref","is-referenced-by-count":70,"title":["Sulfur metabolism and its contribution to malignancy"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.ircmb.2019.05.001_bb0010","doi-asserted-by":"crossref","first-page":"29857","DOI":"10.1074\/jbc.M313320200","article-title":"S-glutathiolation of Ras mediates redox-sensitive signaling by angiotensin II in vascular smooth muscle cells","volume":"279","author":"Adachi","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0015","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s10534-011-9421-x","article-title":"Bacterial transport of sulfate, molybdate, and related oxyanions","volume":"24","author":"Aguilar-Barajas","year":"2011","journal-title":"Biometals"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0020","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/s41467-017-01311-y","article-title":"Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics","volume":"8","author":"Akaike","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0025","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1080\/10715762.2018.1468564","article-title":"N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why","volume":"52","author":"Aldini","year":"2018","journal-title":"Free Radic. Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0030","doi-asserted-by":"crossref","first-page":"84140","DOI":"10.18632\/oncotarget.20493","article-title":"A novel polyamine blockade therapy activates an anti-tumor immune response","volume":"8","author":"Alexander","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0035","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fnins.2015.00023","article-title":"Methylglyoxal, the dark side of glycolysis","volume":"9","author":"Allaman","year":"2015","journal-title":"Front. Neurosci."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0040","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nature24637","article-title":"NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis","volume":"551","author":"Alvarez","year":"2017","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0045","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/15569520701212233","article-title":"Distribution of radio-labeled N-Acetyl-L-Cysteine in Sprague-Dawley rats and its effect on glutathione metabolism following single and repeat dosing by oral gavage","volume":"26","author":"Arfsten","year":"2007","journal-title":"Cutan. Ocul. Toxicol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0050","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s12149-016-1098-3","article-title":"(11)C-methylaminoisobutyric acid (MeAIB) PET for evaluation of prostate cancer: compared with (18)F-fluorodeoxyglucose PET","volume":"30","author":"Arimoto","year":"2016","journal-title":"Ann. Nucl. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0055","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1158\/1541-7786.MCR-06-0439","article-title":"Hydrogen sulfide induces direct radical-associated DNA damage","volume":"5","author":"Attene-Ramos","year":"2007","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0060","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/oxfordjournals.aob.a089968","article-title":"Studies on the sulphur bacteria","volume":"39","author":"Baas-Becking","year":"1925","journal-title":"Ann. Bot."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0065","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1074\/jbc.272.1.217","article-title":"Epidermal growth factor (EGF)-induced generation of hydrogen peroxide. Role in EGF receptor-mediated tyrosine phosphorylation","volume":"272","author":"Bae","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0070","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.tibs.2008.06.006","article-title":"The undertow of sulfur metabolism on glutamatergic neurotransmission","volume":"33","author":"Banerjee","year":"2008","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0075","doi-asserted-by":"crossref","first-page":"6699","DOI":"10.1021\/bi990240v","article-title":"Regulation of PTP1B via glutathionylation of the active site cysteine 215","volume":"38","author":"Barrett","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0080","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1101\/sqb.2005.70.010","article-title":"Aberrant gene silencing in tumor progression: implications for control of cancer","volume":"70","author":"Baylin","year":"2005","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0085","doi-asserted-by":"crossref","first-page":"9306","DOI":"10.1073\/pnas.0503674102","article-title":"An obligately photosynthetic bacterial anaerobe from a deep-sea hydrothermal vent","volume":"102","author":"Beatty","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0090","doi-asserted-by":"crossref","first-page":"1600391","DOI":"10.1002\/pmic.201600391","article-title":"From structure to redox: the diverse functional roles of disulfides and implications in disease","volume":"17","author":"Bechtel","year":"2017","journal-title":"Proteomics"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0095","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1126\/science.aad0489","article-title":"mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle","volume":"351","author":"Ben-Sahra","year":"2016","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079167","article-title":"Cystathionine beta-synthase (CBS) contributes to advanced ovarian cancer progression and drug resistance","volume":"8","author":"Bhattacharyya","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0105","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2015.07.016","article-title":"An essential role of the mitochondrial electron transport chain in cell proliferation is to enable aspartate synthesis","volume":"162","author":"Birsoy","year":"2015","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0110","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/s41586-018-0622-0","article-title":"A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling","volume":"562","author":"Bollong","year":"2018","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0115","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ccr.2006.10.020","article-title":"A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth","volume":"11","author":"Bonnet","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0120","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.febslet.2015.01.027","article-title":"The mitochondrial dicarboxylate and 2-oxoglutarate carriers do not transport glutathione","volume":"589","author":"Booty","year":"2015","journal-title":"FEBS Lett."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0125","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/0008-8749(87)90060-8","article-title":"Increased ornithine decarboxylase activity and polyamine biosynthesis are required for optimal cytolytic T lymphocyte induction","volume":"105","author":"Bowlin","year":"1987","journal-title":"Cell. Immunol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0130","first-page":"4510","article-title":"Effects of three irreversible inhibitors of ornithine decarboxylase on macrophage-mediated tumoricidal activity and antitumor activity in B16F1 tumor-bearing mice","volume":"50","author":"Bowlin","year":"1990","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044951","article-title":"Cysteine dioxygenase 1 is a tumor suppressor gene silenced by promoter methylation in multiple human cancers","volume":"7","author":"Brait","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0140","first-page":"861","article-title":"Decreased rat rhabdomyosarcoma pulmonary metastases in response to a low methionine diet","volume":"7","author":"Breillout","year":"1987","journal-title":"Anticancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0145","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1476-5381.2011.01480.x","article-title":"System xc\u2212 cystine\/glutamate antiporter: an update on molecular pharmacology and roles within the CNS","volume":"165","author":"Bridges","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0150","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1093\/oxfordjournals.molbev.a003988","article-title":"Evolution of amino acid frequencies in proteins over deep time: inferred order of introduction of amino acids into the genetic code","volume":"19","author":"Brooks","year":"2002","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0155","doi-asserted-by":"crossref","first-page":"1636S","DOI":"10.1093\/jn\/136.6.1636S","article-title":"The sulfur-containing amino acids: an overview","volume":"136","author":"Brosnan","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0160","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1042\/BJ20150837","article-title":"Division of labour: how does folate metabolism partition between one-carbon metabolism and amino acid oxidation?","volume":"472","author":"Brosnan","year":"2015","journal-title":"Biochem. J."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0165","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1038\/bjc.2012.138","article-title":"The differential effects of statins on the metastatic behaviour of prostate cancer","volume":"106","author":"Brown","year":"2012","journal-title":"Br. J. Cancer"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2741\/3228","article-title":"Discovery of the nitric oxide signaling pathway and targets for drug development","volume":"14","author":"Bryan","year":"2009","journal-title":"Front. Biosci. (Landmark Ed.)"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0175","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/nature23481","article-title":"Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism","volume":"548","author":"Burgos-Barragan","year":"2017","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0180","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1432-1033.1987.tb13699.x","article-title":"Purification and comparison of two forms of S-adenosyl-L-methionine synthetase from rat liver","volume":"170","author":"Cabrero","year":"1987","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0185","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1042\/CBI20090368","article-title":"Hydrogen sulfide induces human colon cancer cell proliferation: role of Akt, ERK and p21","volume":"34","author":"Cai","year":"2010","journal-title":"Cell Biol. Int."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0190","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1073\/pnas.1014739108","article-title":"Therapeutic enzyme deimmunization by combinatorial T-cell epitope removal using neutral drift","volume":"108","author":"Cantor","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0195","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1089\/ars.2009.2915","article-title":"Butyrate-stimulated H2S production in colon cancer cells","volume":"12","author":"Cao","year":"2010","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0200","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1093\/hmg\/ddt639","article-title":"Germline mutations in FH confer predisposition to malignant pheochromocytomas and paragangliomas","volume":"23","author":"Castro-Vega","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0205","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1086\/302752","article-title":"Methionine adenosyltransferase I\/III deficiency: novel mutations and clinical variations","volume":"66","author":"Chamberlin","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0210","doi-asserted-by":"crossref","first-page":"6353","DOI":"10.1158\/0008-5472.CAN-05-4533","article-title":"Nitric oxide regulates cell sensitivity to cisplatin-induced apoptosis through S-nitrosylation and inhibition of Bcl-2 ubiquitination","volume":"66","author":"Chanvorachote","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0215","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bcp.2018.05.003","article-title":"Exploiting methionine restriction for cancer treatment","volume":"154","author":"Chaturvedi","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0220","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S0022-3565(24)37484-1","article-title":"Evidence for mitochondrial uptake of glutathione by dicarboxylate and 2-oxoglutarate carriers","volume":"285","author":"Chen","year":"1998","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0225","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/abbi.1999.1527","article-title":"Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria: further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport","volume":"373","author":"Chen","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0230","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/jnr.10027","article-title":"Role of taurine in regulation of intracellular calcium level and neuroprotective function in cultured neurons","volume":"66","author":"Chen","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0235","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.18632\/oncotarget.1540","article-title":"Phosphoglycerate dehydrogenase is dispensable for breast tumor maintenance and growth","volume":"4","author":"Chen","year":"2013","journal-title":"Oncotarget"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0240","doi-asserted-by":"crossref","first-page":"11601","DOI":"10.1074\/jbc.M808026200","article-title":"H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia","volume":"284","author":"Chiku","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7258(99)00047-9","article-title":"Molecular genetics of hepatic methionine adenosyltransferase deficiency","volume":"85","author":"Chou","year":"2000","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0250","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/embor.2011.43","article-title":"The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases","volume":"12","author":"Chowdhury","year":"2011","journal-title":"EMBO Rep."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0255","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1161\/CIRCRESAHA.112.268680","article-title":"Cysteine oxidative posttranslational modifications: emerging regulation in the cardiovascular system","volume":"112","author":"Chung","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0260","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1158\/0008-5472.CAN-06-3986","article-title":"Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond","volume":"67","author":"Cohen","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0265","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1021\/bi801805h","article-title":"S-Nitrosoglutathione inactivation of the mitochondrial and cytosolic BCAT proteins: S-nitrosation and S-thiolation","volume":"48","author":"Coles","year":"2009","journal-title":"Biochemistry"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0270","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1016\/j.freeradbiomed.2008.02.013","article-title":"Zinc protects endothelial cells from hydrogen peroxide via Nrf2-dependent stimulation of glutathione biosynthesis","volume":"44","author":"Cortese","year":"2008","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0275","first-page":"1169","article-title":"Gamma-glutamyltransferase of cancer cells at the crossroads of tumor progression, drug resistance and drug targeting","volume":"30","author":"Corti","year":"2010","journal-title":"Anticancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0280","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1158\/1535-7163.MCT-10-0798","article-title":"Increased sensitivity to thiopurines in methylthioadenosine phosphorylase-deleted cancers","volume":"10","author":"Coulthard","year":"2011","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0285","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/onc.2009.368","article-title":"Enhanced mRNA cap methylation increases cyclin D1 expression and promotes cell transformation","volume":"29","author":"Cowling","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0290","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/nm.4232","article-title":"Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth","volume":"23","author":"Cramer","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0295","doi-asserted-by":"crossref","first-page":"8297","DOI":"10.1074\/jbc.RA118.001885","article-title":"Acute loss of iron-sulfur clusters results in metabolic reprogramming and generation of lipid droplets in mammalian cells","volume":"293","author":"Crooks","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0300","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41419-017-0129-x","article-title":"N6-methyladenosine links RNA metabolism to cancer progression","volume":"9","author":"Dai","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0305","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nature08617","article-title":"Cancer-associated IDH1 mutations produce 2-hydroxyglutarate","volume":"462","author":"Dang","year":"2009","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0310","doi-asserted-by":"crossref","first-page":"18628","DOI":"10.1073\/pnas.1010171107","article-title":"Methionine sulfoxide reductase A down-regulation in human breast cancer cells results in a more aggressive phenotype","volume":"107","author":"De Luca","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0315","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1101\/gad.2037511","article-title":"CpG islands and the regulation of transcription","volume":"25","author":"Deaton","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0320","doi-asserted-by":"crossref","first-page":"6359","DOI":"10.1039\/c2dt12188c","article-title":"Chelation therapy in Wilson's disease: from D-penicillamine to the design of selective bioinspired intracellular Cu(I) chelators","volume":"41","author":"Delangle","year":"2012","journal-title":"Dalton Trans."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0325","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nature10189","article-title":"Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis","volume":"475","author":"DeNicola","year":"2011","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0330","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/ng.3421","article-title":"NRF2 regulates serine biosynthesis in non-small cell lung cancer","volume":"47","author":"DeNicola","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0335","doi-asserted-by":"crossref","first-page":"112","DOI":"10.15698\/mic2017.04.567","article-title":"Thiol trapping and metabolic redistribution of sulfur metabolites enable cells to overcome cysteine overload","volume":"4","author":"Deshpande","year":"2017","journal-title":"Microb. Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0340","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1056\/NEJMoa1716984","article-title":"Durable remissions with ivosidenib in IDH1-mutated relapsed or refractory AML","volume":"378","author":"DiNardo","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0345","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0350","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.02523","article-title":"Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis","volume":"3","author":"Dixon","year":"2014","journal-title":"Elife"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0355","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1128\/MCB.18.3.1459","article-title":"Initiator-elongator discrimination in vertebrate tRNAs for protein synthesis","volume":"18","author":"Drabkin","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0360","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1523\/JNEUROSCI.19-02-00562.1999","article-title":"Synthesis of the antioxidant glutathione in neurons: supply by astrocytes of CysGly as precursor for neuronal glutathione","volume":"19","author":"Dringen","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0365","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2016.08.009","article-title":"One-carbon metabolism in health and disease","volume":"25","author":"Ducker","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0370","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.cmet.2016.04.016","article-title":"Reversal of cytosolic one-carbon flux compensates for loss of the mitochondrial folate pathway","volume":"23","author":"Ducker","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0375","first-page":"2798","article-title":"Selective modulation by alpha-difluoromethylornithine of T-lymphocyte and antibody-mediated cytotoxic responses to mouse tumor allografts","volume":"46","author":"Ehrke","year":"1986","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0380","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/978-1-4615-0077-3_63","article-title":"Taurine regulates mitochondrial calcium homeostasis","volume":"526","author":"El Idrissi","year":"2003","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0385","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.1158\/0008-5472.CAN-17-3370","article-title":"The EGFR T790M mutation is acquired through AICDA-mediated deamination of 5-methylcytosine following TKI treatment in lung cancer","volume":"78","author":"El Kadi","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0390","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1007\/s00535-004-1471-1","article-title":"Immunohistochemical metallothionein expression in hepatocellular carcinoma: relation to tumor progression and chemoresistance to platinum agents","volume":"39","author":"Endo","year":"2004","journal-title":"J. Gastroenterol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0395","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1207\/S15327914NC422_2","article-title":"Nutrient intake and nutritional indexes in adults with metastatic cancer on a phase I clinical trial of dietary methionine restriction","volume":"42","author":"Epner","year":"2002","journal-title":"Nutr. Cancer"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0400","doi-asserted-by":"crossref","DOI":"10.1016\/j.chembiol.2018.01.011","article-title":"N-Acetyl cysteine functions as a fast-acting antioxidant by triggering intracellular H2S and sulfane sulfur production","volume":"25","author":"Ezerina","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0405","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0410","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4684-3282-4_1","article-title":"Biologically important thiol-disulfide reactions and the role of cyst(e)ine in proteins: an evolutionary perspective","volume":"86A","author":"Fahey","year":"1977","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0415","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF01751808","article-title":"On the cysteine and cystine content of proteins. Differences between intracellular and extracellular proteins","volume":"10","author":"Fahey","year":"1977","journal-title":"J. Mol. Evol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0420","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.celrep.2017.12.051","article-title":"Defective mitochondrial tRNA taurine modification activates global proteostress and leads to mitochondrial disease","volume":"22","author":"Fakruddin","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0425","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1146\/annurev.bi.44.070175.004441","article-title":"Amino acid metabolism in man","volume":"44","author":"Felig","year":"1975","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0430","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1021\/tx100413v","article-title":"Factors affecting protein thiol reactivity and specificity in peroxide reduction","volume":"24","author":"Ferrer-Sueta","year":"2011","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0435","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1083\/jcb.201102095","article-title":"Signal transduction by reactive oxygen species","volume":"194","author":"Finkel","year":"2011","journal-title":"J. Cell Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0440","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1055\/s-2000-8466","article-title":"Pathways and regulation of homocysteine metabolism in mammals","volume":"26","author":"Finkelstein","year":"2000","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0445","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1074\/mcp.M600225-MCP200","article-title":"The proteomics of N-terminal methionine cleavage","volume":"5","author":"Frottin","year":"2006","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0450","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1073\/pnas.1115634109","article-title":"Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production","volume":"109","author":"Fu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0455","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1172\/JCI6816","article-title":"Interaction between succinyl CoA synthetase and the heme-biosynthetic enzyme ALAS-E is disrupted in sideroblastic anemia","volume":"105","author":"Furuyama","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.urolonc.2015.06.020","article-title":"Expression profile of hydrogen sulfide and its synthases correlates with tumor stage and grade in urothelial cell carcinoma of bladder","volume":"34","author":"Gai","year":"2016","journal-title":"Urol. Oncol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0465","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/toxsci\/kfj061","article-title":"Human sulfotransferases and their role in chemical metabolism","volume":"90","author":"Gamage","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0470","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.ccr.2007.08.004","article-title":"HIF-dependent antitumorigenic effect of antioxidants in vivo","volume":"12","author":"Gao","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of mitochondria in ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0480","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1021\/acschembio.8b00199","article-title":"Determination of the subcellular localization and mechanism of action of ferrostatins in suppressing ferroptosis","volume":"13","author":"Gaschler","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0485","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/nyas.12379","article-title":"Design of intrahepatocyte copper(I) chelators as drug candidates for Wilson's disease","volume":"1315","author":"Gateau","year":"2014","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0490","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00259-012-2295-5","article-title":"Value of 11C-methionine PET in imaging brain tumours and metastases","volume":"40","author":"Glaudemans","year":"2013","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0495","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.bbagen.2008.01.011","article-title":"Redox compartmentalization in eukaryotic cells","volume":"1780","author":"Go","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0500","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/978-1-60327-461-6_17","article-title":"Quantification of redox conditions in the nucleus","volume":"464","author":"Go","year":"2009","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.02.001","article-title":"Remnants of an ancient metabolism without phosphate","volume":"168","author":"Goldford","year":"2017","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0510","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1161\/CIRCULATIONAHA.106.621854","article-title":"Advanced glycation end products: sparking the development of diabetic vascular injury","volume":"114","author":"Goldin","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0515","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nrd4002","article-title":"Modulation of oxidative stress as an anticancer strategy","volume":"12","author":"Gorrini","year":"2013","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0520","first-page":"1052","article-title":"Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype\/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency","volume":"56","author":"Goyette","year":"1995","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0525","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/nature08619","article-title":"Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila","volume":"462","author":"Grandison","year":"2009","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0530","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1158\/0008-5472.CAN-05-3364","article-title":"Xanthine oxidase-dependent regulation of hypoxia-inducible factor in cancer cells","volume":"66","author":"Griguer","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0535","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2017.05.030","article-title":"mTORC2 regulates amino acid metabolism in cancer by phosphorylation of the cystine-glutamate antiporter xCT","volume":"67","author":"Gu","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0540","first-page":"5676","article-title":"Therapeutic tumor-specific cell cycle block induced by methionine starvation in vivo","volume":"53","author":"Guo","year":"1993","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0545","doi-asserted-by":"crossref","first-page":"17428","DOI":"10.1074\/jbc.M401493200","article-title":"Identification of methionine-rich clusters that regulate copper-stimulated endocytosis of the human Ctr1 copper transporter","volume":"279","author":"Guo","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0550","doi-asserted-by":"crossref","first-page":"156","DOI":"10.3389\/fphys.2016.00156","article-title":"Emerging roles of hydrogen sulfide in inflammatory and neoplastic colonic diseases","volume":"7","author":"Guo","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0555","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.redox.2015.03.003","article-title":"Expression of xCT and activity of system xc(\u2212) are regulated by NRF2 in human breast cancer cells in response to oxidative stress","volume":"5","author":"Habib","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0560","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s13073-018-0586-6","article-title":"Distinct microbes, metabolites, and ecologies define the microbiome in deficient and proficient mismatch repair colorectal cancers","volume":"10","author":"Hale","year":"2018","journal-title":"Genome Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0565","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0076-6879(02)48634-X","article-title":"Quantitation of protein sulfinic and sulfonic acid, irreversibly oxidized protein cysteine sites in cellular proteins","volume":"348","author":"Hamann","year":"2002","journal-title":"Methods Enzymol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0570","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0575","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0046-8177(99)90009-6","article-title":"Altered expression of gamma-glutamyl transpeptidase in human tumors","volume":"30","author":"Hanigan","year":"1999","journal-title":"Hum. Pathol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0580","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ccell.2014.11.019","article-title":"Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression","volume":"27","author":"Harris","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0585","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1089\/ars.2014.5933","article-title":"The therapeutic potential of cystathionine beta-synthetase\/hydrogen sulfide inhibition in cancer","volume":"22","author":"Hellmich","year":"2015","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0590","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/1097-0215(20010320)95:2<121::AID-IJC1021>3.0.CO;2-N","article-title":"Metallothionein expression in ovarian cancer in relation to histopathological parameters and molecular markers of prognosis","volume":"95","author":"Hengstler","year":"2001","journal-title":"Int. J. Cancer"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0595","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.cell.2015.12.034","article-title":"Metabolic heterogeneity in human lung tumors","volume":"164","author":"Hensley","year":"2016","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0600","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1634\/theoncologist.11-3-306","article-title":"The role of statins in cancer therapy","volume":"11","author":"Hindler","year":"2006","journal-title":"Oncologist"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0605","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1093\/hmg\/ddv149","article-title":"An N-terminal formyl methionine on COX 1 is required for the assembly of cytochrome c oxidase","volume":"24","author":"Hinttala","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0610","doi-asserted-by":"crossref","first-page":"38777","DOI":"10.18632\/oncotarget.6091","article-title":"Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma\/pheochromocytoma and smooth muscle tumors","volume":"6","author":"Hoekstra","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0615","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1469-7793.2001.0001j.x","article-title":"Regulation of cell function by methionine oxidation and reduction","volume":"531","author":"Hoshi","year":"2001","journal-title":"J. Physiol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0620","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1186\/1752-1947-4-409","article-title":"Rapidly progressive polyneuropathy due to dry beriberi in a man: a case report","volume":"4","author":"Howard","year":"2010","journal-title":"J. Med. Case Reports"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0625","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1002\/ijc.24104","article-title":"Methionine depletion with recombinant methioninase: in vitro and in vivo efficacy against neuroblastoma and its synergism with chemotherapeutic drugs","volume":"124","author":"Hu","year":"2009","journal-title":"Int. J. Cancer"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0630","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/nature08724","article-title":"Mical links semaphorins to F-actin disassembly","volume":"463","author":"Hung","year":"2010","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0635","series-title":"Biochemistry of sulfur","author":"Huxtable","year":"1986"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0640","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1073\/pnas.1321232111","article-title":"Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling","volume":"111","author":"Ida","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0645","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1007\/s10803-008-0591-5","article-title":"Abnormal transmethylation\/transsulfuration metabolism and DNA hypomethylation among parents of children with autism","volume":"38","author":"James","year":"2008","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0650","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.7150\/thno.18005","article-title":"Cysteine transporter SLC3A1 promotes breast cancer tumorigenesis","volume":"7","author":"Jiang","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0655","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/carcin\/23.1.81","article-title":"Metallothionein 2A expression is associated with cell proliferation in breast cancer","volume":"23","author":"Jin","year":"2002","journal-title":"Carcinogenesis"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0660","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.3390\/ijms13033145","article-title":"Glutathione is a key player in metal-induced oxidative stress defenses","volume":"13","author":"Jozefczak","year":"2012","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0665","doi-asserted-by":"crossref","first-page":"e45572","DOI":"10.7554\/eLife.45572","article-title":"Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer","volume":"8","author":"Kang","year":"2019","journal-title":"eLife"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0670","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood-2013-10-533604","article-title":"IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition","volume":"125","author":"Kernytsky","year":"2015","journal-title":"Blood"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0675","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1002\/(SICI)1097-4547(19990715)57:2<280::AID-JNR14>3.0.CO;2-U","article-title":"Neurotoxicity of methylglyoxal and 3-deoxyglucosone on cultured cortical neurons: synergism between glycation and oxidative stress, possibly involved in neurodegenerative diseases","volume":"57","author":"Kikuchi","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0680","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1128\/MCB.01080-08","article-title":"The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds","volume":"29","author":"Kobayashi","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0685","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.nucmedbio.2012.06.006","article-title":"Transport mechanism of (11)C-labeled L- and D-methionine in human-derived tumor cells","volume":"39","author":"Kobayashi","year":"2012","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0690","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1161\/CIRCRESAHA.110.232173","article-title":"Simultaneous measurement of protein oxidation and S-nitrosylation during preconditioning and ischemia\/reperfusion injury with resin-assisted capture","volume":"108","author":"Kohr","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0695","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194785","article-title":"Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer","volume":"13","author":"Kojima","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0700","first-page":"4017","article-title":"Synergy between methionine stress and chemotherapy in the treatment of brain tumor xenografts in athymic mice","volume":"61","author":"Kokkinakis","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0705","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1207\/s15327914nc5402_6","article-title":"Methionine restriction inhibits colon carcinogenesis","volume":"54","author":"Komninou","year":"2006","journal-title":"Nutr. Cancer"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0710","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nature20132","article-title":"LKB1 loss links serine metabolism to DNA methylation and tumorigenesis","volume":"539","author":"Kottakis","year":"2016","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0715","doi-asserted-by":"crossref","first-page":"ra86","DOI":"10.1126\/scisignal.2002329","article-title":"H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response","volume":"4","author":"Krishnan","year":"2011","journal-title":"Sci. Signal."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0720","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1126\/science.aad5214","article-title":"MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells","volume":"351","author":"Kryukov","year":"2016","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0725","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/B978-0-12-380866-0.60002-2","article-title":"DNA methylation and cancer","volume":"70","author":"Kulis","year":"2010","journal-title":"Adv. Genet."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0730","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0014-5793(99)00917-5","article-title":"Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA)","volume":"456","author":"Kuschel","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0735","doi-asserted-by":"crossref","first-page":"E804","DOI":"10.1152\/ajpendo.2001.280.5.E804","article-title":"Cysteine regulates expression of cysteine dioxygenase and gamma-glutamylcysteine synthetase in cultured rat hepatocytes","volume":"280","author":"Kwon","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0740","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev-biochem-060713-035504","article-title":"Radical S-adenosylmethionine enzymes in human health and disease","volume":"85","author":"Landgraf","year":"2016","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0745","doi-asserted-by":"crossref","first-page":"11641","DOI":"10.1074\/jbc.M117.788547","article-title":"H2S oxidation by nanodisc-embedded human sulfide quinone oxidoreductase","volume":"292","author":"Landry","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0750","doi-asserted-by":"crossref","first-page":"254","DOI":"10.7150\/thno.13921","article-title":"11C-methionine-PET in multiple myeloma: correlation with clinical parameters and bone marrow involvement","volume":"6","author":"Lapa","year":"2016","journal-title":"Theranostics"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0755","doi-asserted-by":"crossref","first-page":"308re8","DOI":"10.1126\/scitranslmed.aad3740","article-title":"Antioxidants can increase melanoma metastasis in mice","volume":"7","author":"Le Gal","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0760","doi-asserted-by":"crossref","first-page":"20336","DOI":"10.1074\/jbc.M111899200","article-title":"Reversible inactivation of the tumor suppressor PTEN by H2O2","volume":"277","author":"Lee","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0765","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1089\/ars.2011.4322","article-title":"Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance","volume":"18","author":"Lee","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0770","doi-asserted-by":"crossref","first-page":"18928","DOI":"10.1038\/srep18928","article-title":"Oxidative dimerization of PHD2 is responsible for its inactivation and contributes to metabolic reprogramming via HIF-1alpha activation","volume":"6","author":"Lee","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0775","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ccr.2013.04.018","article-title":"SDH mutations establish a hypermethylator phenotype in paraganglioma","volume":"23","author":"Letouze","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0780","doi-asserted-by":"crossref","first-page":"15036","DOI":"10.1073\/pnas.93.26.15036","article-title":"Methionine residues as endogenous antioxidants in proteins","volume":"93","author":"Levine","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0785","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1089\/ars.2011.4391","article-title":"The cystine\/glutamate antiporter system x(c)(\u2212) in health and disease: from molecular mechanisms to novel therapeutic opportunities","volume":"18","author":"Lewerenz","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0790","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1056\/NEJMoa1005143","article-title":"DNMT3A mutations in acute myeloid leukemia","volume":"363","author":"Ley","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0795","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.molcel.2007.02.024","article-title":"Regulation of HIF-1alpha stability through S-nitrosylation","volume":"26","author":"Li","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0800","doi-asserted-by":"crossref","first-page":"15789","DOI":"10.1074\/jbc.M110.188524","article-title":"Catalysis and pH control by membrane-associated carbonic anhydrase IX in MDA-MB-231 breast cancer cells","volume":"286","author":"Li","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0805","doi-asserted-by":"crossref","first-page":"eaao6604","DOI":"10.1126\/scisignal.aao6604","article-title":"Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT","volume":"10","author":"Lien","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0810","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1158\/0008-5472.CAN-09-3648","article-title":"Plasma homocysteine and cysteine and risk of breast cancer in women","volume":"70","author":"Lin","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0815","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.stem.2014.03.005","article-title":"Hydrogen sulfide maintains mesenchymal stem cell function and bone homeostasis via regulation of Ca(2+) channel sulfhydration","volume":"15","author":"Liu","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0820","doi-asserted-by":"crossref","first-page":"14844","DOI":"10.1038\/ncomms14844","article-title":"Inhibiting the system xC(\u2212)\/glutathione axis selectively targets cancers with mutant-p53 accumulation","volume":"8","author":"Liu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0825","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3747\/co.v17i3.485","article-title":"Potential use of the anti-inflammatory drug, sulfasalazine, for targeted therapy of pancreatic cancer","volume":"17","author":"Lo","year":"2010","journal-title":"Curr. Oncol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0830","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/ng.890","article-title":"Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis","volume":"43","author":"Locasale","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0835","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1007\/s13277-015-4290-5","article-title":"HNF1beta drives glutathione (GSH) synthesis underlying intrinsic carboplatin resistance of ovarian clear cell carcinoma (OCCC)","volume":"37","author":"Lopes-Coelho","year":"2016","journal-title":"Tumour Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0840","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.mam.2008.05.005","article-title":"Regulation of glutathione synthesis","volume":"30","author":"Lu","year":"2009","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0845","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1152\/physrev.00047.2011","article-title":"S-adenosylmethionine in liver health, injury, and cancer","volume":"92","author":"Lu","year":"2012","journal-title":"Physiol. Rev."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0850","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1089\/ars.2010.3586","article-title":"Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities","volume":"15","author":"Lubos","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0855","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cmet.2016.12.011","article-title":"Serine is an essential metabolite for effector T cell expansion","volume":"25","author":"Ma","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0860","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.molcel.2015.12.014","article-title":"Serine metabolism supports the methionine cycle and DNA\/RNA methylation through de novo ATP synthesis in cancer cells","volume":"61","author":"Maddocks","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0865","doi-asserted-by":"crossref","first-page":"11920","DOI":"10.1074\/jbc.M112.433847","article-title":"Voltage-dependent anion channels modulate mitochondrial metabolism in cancer cells: regulation by free tubulin and erastin","volume":"288","author":"Maldonado","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0870","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1089\/ars.2013.5324","article-title":"Hydrogen sulfide and the pathogenesis of atherosclerosis","volume":"20","author":"Mani","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0875","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.freeradbiomed.2017.02.010","article-title":"Regulated methionine oxidation by monooxygenases","volume":"109","author":"Manta","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0880","doi-asserted-by":"crossref","first-page":"6235641","DOI":"10.1155\/2016\/6235641","article-title":"Redox homeostasis and cellular antioxidant systems: crucial players in cancer growth and therapy","volume":"2016","author":"Marengo","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0885","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/hep.22159","article-title":"Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice","volume":"47","author":"Martinez-Chantar","year":"2008","journal-title":"Hepatology"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0890","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.molcel.2015.12.002","article-title":"TCA cycle and mitochondrial membrane potential are necessary for diverse biological functions","volume":"61","author":"Martinez-Reyes","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0895","series-title":"Glutathione and Sulfur Amino Acids in Human Health and Disease","author":"Masella","year":"2009"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0900","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1164\/rccm.200411-1523OC","article-title":"Abnormalities in nitric oxide and its derivatives in lung cancer","volume":"172","author":"Masri","year":"2005","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0905","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/s10545-014-9705-8","article-title":"Lipoic acid biosynthesis defects","volume":"37","author":"Mayr","year":"2014","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0910","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00726-011-0864-8","article-title":"The transsulfuration pathway: a source of cysteine for glutathione in astrocytes","volume":"42","author":"McBean","year":"2012","journal-title":"Amino Acids"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0915","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1158\/0008-5472.CAN-18-2634","article-title":"Assessment of tumor redox status through (S)-4-(3-[(18)F]fluoropropyl)-L-glutamic acid PET imaging of system xc (\u2212) activity","volume":"79","author":"McCormick","year":"2019","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0920","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.taap.2018.09.033","article-title":"Zinc-binding triggers a conformational-switch in the cullin-3 substrate adaptor protein KEAP1 that controls transcription factor NRF2","volume":"360","author":"McMahon","year":"2018","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0925","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/ijc.30526","article-title":"Effects of statins on cancer mortality and progression: a systematic review and meta-analysis of 95 cohorts including 1,111,407 individuals","volume":"140","author":"Mei","year":"2017","journal-title":"Int. J. Cancer"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0930","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cmet.2015.08.024","article-title":"Histone methylation dynamics and gene regulation occur through the sensing of one-carbon metabolism","volume":"22","author":"Mentch","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0935","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/sj.bjc.6604554","article-title":"Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer","volume":"99","author":"Michelakis","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0940","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbrc.2013.01.010","article-title":"Hydrogen sulfide is produced by cystathionine gamma-lyase at the steady-state low intracellular Ca(2+) concentrations","volume":"431","author":"Mikami","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0945","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.01.024","article-title":"Serine catabolism by SHMT2 is required for proper mitochondrial translation initiation and maintenance of formylmethionyl-tRNAs","volume":"69","author":"Minton","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0950","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1093\/oxfordjournals.molbev.a026406","article-title":"Relationship between the occurrence of cysteine in proteins and the complexity of organisms","volume":"17","author":"Miseta","year":"2000","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0955","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbapap.2004.09.003","article-title":"Methionine sulfoxide reductases: ubiquitous enzymes involved in antioxidant defense, protein regulation, and prevention of aging-associated diseases","volume":"1703","author":"Moskovitz","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0960","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bbabio.2012.11.014","article-title":"The function and the role of the mitochondrial glycerol-3-phosphate dehydrogenase in mammalian tissues","volume":"1827","author":"Mracek","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0965","doi-asserted-by":"crossref","first-page":"4382","DOI":"10.1016\/S0021-9258(18)97073-0","article-title":"Transsulfuration in mammals. Microassays and tissue distributions of three enzymes of the pathway","volume":"240","author":"Mudd","year":"1965","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0970","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1073\/pnas.1521548113","article-title":"Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers","volume":"113","author":"Mullarky","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0975","doi-asserted-by":"crossref","first-page":"6462","DOI":"10.1021\/jm7011497","article-title":"Novel, orally effective cyanide antidotes","volume":"50","author":"Nagasawa","year":"2007","journal-title":"J. Med. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0980","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cmet.2011.08.015","article-title":"Activation of the HIF prolyl hydroxylase by the iron chaperones Pcbp1 and PCBP2","volume":"14","author":"Nandal","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0985","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nature08576","article-title":"Innate immune and chemically triggered oxidative stress modifies translational fidelity","volume":"462","author":"Netzer","year":"2009","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0990","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ccr.2005.03.036","article-title":"Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation","volume":"7","author":"Nilsson","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb0995","doi-asserted-by":"crossref","DOI":"10.1017\/erm.2013.3","article-title":"Polyamines and cancer: implications for chemotherapy and chemoprevention","volume":"15","author":"Nowotarski","year":"2013","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1000","doi-asserted-by":"crossref","first-page":"9513","DOI":"10.1038\/s41598-018-27753-y","article-title":"Cysteine allows ovarian cancer cells to adapt to hypoxia and to escape from carboplatin cytotoxicity","volume":"8","author":"Nunes","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1005","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0006-8993(81)90538-2","article-title":"Inhibitory actions of taurocyamine, hypotaurine, homotaurine, taurine and GABA on spike discharges of Purkinje cells, and localization of sensitive sites, in guinea pig cerebellar slices","volume":"206","author":"Okamoto","year":"1981","journal-title":"Brain Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1010","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.acthis.2008.11.004","article-title":"Nervous control of circulation--the role of gasotransmitters, NO, CO, and H2S","volume":"111","author":"Olson","year":"2009","journal-title":"Acta Histochem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1015","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1093\/jn\/123.2.269","article-title":"Low methionine ingestion by rats extends life span","volume":"123","author":"Orentreich","year":"1993","journal-title":"J. Nutr."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1020","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/B978-0-12-800101-1.00011-9","article-title":"The impact of dietary methionine restriction on biomarkers of metabolic health","volume":"121","author":"Orgeron","year":"2014","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1025","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s10620-007-9900-7","article-title":"Methionine deficiency and hepatic injury in a dietary steatohepatitis model","volume":"53","author":"Oz","year":"2008","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136822","article-title":"Dysregulated hepatic methionine metabolism drives homocysteine elevation in diet-induced nonalcoholic fatty liver disease","volume":"10","author":"Pacana","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1035","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/nchembio.2070","article-title":"A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate","volume":"12","author":"Pacold","year":"2016","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1040","first-page":"21","article-title":"The amino acid transport system b(o,+) and cystinuria","volume":"18","author":"Palacin","year":"2001","journal-title":"Mol. Membr. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1045","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1667\/RR14177.1","article-title":"Radiation exposure promotes hepatocarcinoma cell invasion through epithelial mesenchymal transition mediated by H2S\/Cse pathway","volume":"185","author":"Pan","year":"2016","journal-title":"Radiat. Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1050","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/pcmr.12312","article-title":"Role of the cystathionine gamma lyase\/hydrogen sulfide pathway in human melanoma progression","volume":"28","author":"Panza","year":"2015","journal-title":"Pigment Cell Melanoma Res."},{"issue":"Suppl. 1","key":"10.1016\/bs.ircmb.2019.05.001_bb1055","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/S0022-510X(97)00246-3","article-title":"Toxicity of cysteine and cysteine sulphinic acid to human neuronal cell-lines","volume":"152","author":"Parsons","year":"1997","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1060","article-title":"ROS and oxidative stress are elevated in mitosis during asynchronous cell cycle progression and are exacerbated by mitotic arrest","volume":"8","author":"Patterson","year":"2019","journal-title":"Cell Syst."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","article-title":"The emerging hallmarks of cancer metabolism","volume":"23","author":"Pavlova","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1070","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.proghi.2008.10.001","article-title":"The role of metallothionein in oncogenesis and cancer prognosis","volume":"44","author":"Pedersen","year":"2009","journal-title":"Prog. Histochem. Cytochem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.05.003","article-title":"The U6 snRNA m(6)A methyltransferase METTL16 regulates SAM synthetase intron retention","volume":"169","author":"Pendleton","year":"2017","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1080","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1097\/00004647-200008000-00003","article-title":"Altered central nervous system cytokine-growth factor expression profiles and angiogenesis in metallothionein-I+II deficient mice","volume":"20","author":"Penkowa","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1085","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/S0165-5728(01)00357-5","article-title":"Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis","volume":"119","author":"Penkowa","year":"2001","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1090","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nchembio.1720","article-title":"A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation","volume":"11","author":"Peralta","year":"2015","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1095","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nature15726","article-title":"Oxidative stress inhibits distant metastasis by human melanoma cells","volume":"527","author":"Piskounova","year":"2015","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1100","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.freeradbiomed.2014.11.013","article-title":"The basics of thiols and cysteines in redox biology and chemistry","volume":"80","author":"Poole","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1105","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1146\/annurev.pharmtox.44.101802.121735","article-title":"Protein sulfenic acids in redox signaling","volume":"44","author":"Poole","year":"2004","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1110","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/cr.2017.155","article-title":"Mitochondrial metabolism and cancer","volume":"28","author":"Porporato","year":"2018","journal-title":"Cell Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1115","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature10350","article-title":"Functional genomics reveal that the serine synthesis pathway is essential in breast cancer","volume":"476","author":"Possemato","year":"2011","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1120","doi-asserted-by":"crossref","first-page":"164","DOI":"10.4161\/cc.3.2.618","article-title":"Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target","volume":"3","author":"Potter","year":"2004","journal-title":"Cell Cycle"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1125","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1158\/0008-5472.CAN-13-1423","article-title":"Cysteine catabolism: a novel metabolic pathway contributing to glioblastoma growth","volume":"74","author":"Prabhu","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1130","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.132","article-title":"Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer","volume":"7","author":"Qu","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1135","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1006\/abbi.1996.0452","article-title":"Direct reaction of H2O2 with sulfhydryl groups in HL-60 cells: zinc-metallothionein and other sites","volume":"334","author":"Quesada","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1140","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0304-4165(97)00104-9","article-title":"The mode of action of allicin: trapping of radicals and interaction with thiol containing proteins","volume":"1379","author":"Rabinkov","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1145","doi-asserted-by":"crossref","first-page":"3806","DOI":"10.1074\/jbc.M109.059782","article-title":"S-nitrosylation at cysteine 498 of c-Src tyrosine kinase regulates nitric oxide-mediated cell invasion","volume":"285","author":"Rahman","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1150","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3389\/fimmu.2017.00248","article-title":"Metabolic hallmarks of tumor and immune cells in the tumor microenvironment","volume":"8","author":"Renner","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1155","doi-asserted-by":"crossref","first-page":"4581","DOI":"10.1021\/bi00232a031","article-title":"Kinetic parameters for the elimination reaction catalyzed by triosephosphate isomerase and an estimation of the reaction's physiological significance","volume":"30","author":"Richard","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1160","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1126\/science.1236062","article-title":"An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells","volume":"340","author":"Rohle","year":"2013","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1165","doi-asserted-by":"crossref","first-page":"259","DOI":"10.4065\/74.3.259","article-title":"Metabolic acidosis and thiamine deficiency","volume":"74","author":"Romanski","year":"1999","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1170","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1242\/dmm.009019","article-title":"Biogenesis of iron-sulfur clusters in mammalian cells: new insights and relevance to human disease","volume":"5","author":"Rouault","year":"2012","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1175","series-title":"GeneReviews((R))","article-title":"Homocystinuria caused by cystathionine beta-synthase deficiency","author":"Sacharow","year":"1993"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1180","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.3390\/ijms19082373","article-title":"The regulation and function of the L-type amino acid transporter 1 (LAT1) in cancer","volume":"19","author":"Salisbury","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1185","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41598-018-19213-4","article-title":"The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells","volume":"8","author":"Sato","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1190","doi-asserted-by":"crossref","first-page":"5562","DOI":"10.1128\/AEM.00702-06","article-title":"Isolation, characterization, and ecology of cold-active, chemolithotrophic, sulfur-oxidizing bacteria from perennially ice-covered Lake Fryxell, Antarctica","volume":"72","author":"Sattley","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1195","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1574-6941.2009.00709.x","article-title":"Culture-independent analysis of desulfovibrios in the human distal colon of healthy, colorectal cancer and polypectomized individuals","volume":"69","author":"Scanlan","year":"2009","journal-title":"FEMS Microbiol. Ecol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1200","doi-asserted-by":"crossref","first-page":"R453","DOI":"10.1016\/j.cub.2014.03.034","article-title":"ROS function in redox signaling and oxidative stress","volume":"24","author":"Schieber","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1205","doi-asserted-by":"crossref","first-page":"15238","DOI":"10.1016\/S0021-9258(17)36597-3","article-title":"Cytoplasmic metallothionein overexpression protects NIH 3T3 cells from tert-butyl hydroperoxide toxicity","volume":"269","author":"Schwarz","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1210","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0140-6736(81)90650-4","article-title":"The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia","volume":"2","author":"Scott","year":"1981","journal-title":"Lancet"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1215","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nature11126","article-title":"A tumour suppressor network relying on the polyamine-hypusine axis","volume":"487","author":"Scuoppo","year":"2012","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1220","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1399-3054.2006.00822.x","article-title":"Cadmium responses in Arabidopsis thaliana: glutathione metabolism and antioxidative defence system","volume":"129","author":"Semane","year":"2007","journal-title":"Physiol. Plant."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1225","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.freeradbiomed.2015.05.024","article-title":"Role of cystathionine beta-synthase in human breast Cancer","volume":"86","author":"Sen","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1230","doi-asserted-by":"crossref","first-page":"93","DOI":"10.4103\/0972-3919.178254","article-title":"A comparison study of (11)C-methionine and (18)F-fluorodeoxyglucose positron emission tomography-computed tomography scans in evaluation of patients with recurrent brain tumors","volume":"31","author":"Sharma","year":"2016","journal-title":"Indian J. Nucl. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1235","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/nar\/22.6.972","article-title":"The rate of hydrolytic deamination of 5-methylcytosine in double-stranded DNA","volume":"22","author":"Shen","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb9000","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1089\/ars.2008.2253","article-title":"3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain","volume":"11","author":"Shibuya","year":"2009","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1240","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1016\/j.celrep.2017.11.092","article-title":"S-Adenosylmethionine synthesis is regulated by selective N(6)-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1","volume":"21","author":"Shima","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1245","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cmet.2014.03.017","article-title":"Methionine metabolism regulates maintenance and differentiation of human pluripotent stem cells","volume":"19","author":"Shiraki","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1250","doi-asserted-by":"crossref","first-page":"e44210","DOI":"10.7554\/eLife.44210","article-title":"Antigen receptor control of methionine metabolism in T cells","volume":"8","author":"Sinclair","year":"2019","journal-title":"Elife"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1255","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1093\/nar\/29.5.1097","article-title":"Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods","volume":"29","author":"Sofia","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1260","doi-asserted-by":"crossref","first-page":"7522","DOI":"10.1074\/jbc.TM117.000259","article-title":"Lipoic acid metabolism and mitochondrial redox regulation","volume":"293","author":"Solmonson","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"Pt. 2","key":"10.1016\/bs.ircmb.2019.05.001_bb1265","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1469-7793.1998.527bn.x","article-title":"Multiple pathways for L-methionine transport in brush-border membrane vesicles from chicken jejunum","volume":"509","author":"Soriano-Garcia","year":"1998","journal-title":"J. Physiol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1270","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrc3278","article-title":"NRF2 and cancer: the good, the bad and the importance of context","volume":"12","author":"Sporn","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1275","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.redox.2012.11.006","article-title":"Redox biology of hydrogen sulfide: implications for physiology, pathophysiology, and pharmacology","volume":"1","author":"Stein","year":"2013","journal-title":"Redox Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1280","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10545-009-9006-9","article-title":"Dealing with methionine\/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur","volume":"34","author":"Stipanuk","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1285","doi-asserted-by":"crossref","first-page":"1652S","DOI":"10.1093\/jn\/136.6.1652S","article-title":"Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism","volume":"136","author":"Stipanuk","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1290","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1097\/01.ASN.0000029586.17680.E5","article-title":"Comparison between SLC3A1 and SLC7A9 cystinuria patients and carriers: a need for a new classification","volume":"13","author":"Strologo","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1295","doi-asserted-by":"crossref","first-page":"16473","DOI":"10.1074\/jbc.C000205200","article-title":"Cloning of an amino acid transporter with functional characteristics and tissue expression pattern identical to that of system A","volume":"275","author":"Sugawara","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1300","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.cell.2015.07.017","article-title":"Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells","volume":"162","author":"Sullivan","year":"2015","journal-title":"Cell"},{"issue":"Pt. 2","key":"10.1016\/bs.ircmb.2019.05.001_bb1305","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1042\/bj3180379","article-title":"Regulation of reactive-oxygen-species generation in fibroblasts by Rac1","volume":"318","author":"Sundaresan","year":"1996","journal-title":"Biochem. J."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1310","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s00259-002-1010-3","article-title":"Uptake of [N-methyl-11C]alpha-methylaminoisobutyric acid in untreated head and neck cancer studied by PET","volume":"30","author":"Sutinen","year":"2003","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1315","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1093\/emboj\/cdf656","article-title":"Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases","volume":"21","author":"Suzuki","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1320","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/nm.4181","article-title":"Inhibition of acetyl-CoA carboxylase suppresses fatty acid synthesis and tumor growth of non-small-cell lung cancer in preclinical models","volume":"22","author":"Svensson","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1325","doi-asserted-by":"crossref","first-page":"12474","DOI":"10.1073\/pnas.1306241110","article-title":"Tumor-derived hydrogen sulfide, produced by cystathionine-beta-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer","volume":"110","author":"Szabo","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1330","first-page":"794","article-title":"Production of large amounts of hydrogen peroxide by human tumor cells","volume":"51","author":"Szatrowski","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1335","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1365-2443.2010.01473.x","article-title":"Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution","volume":"16","author":"Taguchi","year":"2011","journal-title":"Genes Cells"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1340","first-page":"3937","article-title":"Serum methionine depletion without side effects by methioninase in metastatic breast cancer patients","volume":"16","author":"Tan","year":"1996","journal-title":"Anticancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1345","first-page":"2157","article-title":"Efficacy of recombinant methioninase in combination with cisplatin on human colon tumors in nude mice","volume":"5","author":"Tan","year":"1999","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1350","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1038\/bjc.2016.105","article-title":"Cancer-associated oxidoreductase ERO1-alpha drives the production of VEGF via oxidative protein folding and regulating the mRNA level","volume":"114","author":"Tanaka","year":"2016","journal-title":"Br. J. Cancer"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1355","doi-asserted-by":"crossref","first-page":"4386","DOI":"10.1158\/0008-5472.CAN-18-0814","article-title":"Specific targeting of MTAP-deleted tumors with a combination of 2'-fluoroadenine and 5\u2032-methylthioadenosine","volume":"78","author":"Tang","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1360","doi-asserted-by":"crossref","first-page":"36258","DOI":"10.1074\/jbc.M111.265348","article-title":"Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas","volume":"286","author":"Teng","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1365","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1046\/j.1365-2559.2002.01325.x","article-title":"Expression of metallothionein in lung carcinoma: correlation with histological type and grade","volume":"40","author":"Theocharis","year":"2002","journal-title":"Histopathology"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1370","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.taap.2003.10.020","article-title":"Elucidating the pathway for arsenic methylation","volume":"198","author":"Thomas","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1375","doi-asserted-by":"crossref","first-page":"6128","DOI":"10.1039\/C4OB00382A","article-title":"A fluorescent probe for intracellular cysteine overcoming the interference by glutathione","volume":"12","author":"Tian","year":"2014","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1380","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1097\/PAS.0000000000000617","article-title":"Fumarate hydratase-deficient renal cell carcinoma is strongly correlated with fumarate hydratase mutation and hereditary leiomyomatosis and renal cell carcinoma syndrome","volume":"40","author":"Trpkov","year":"2016","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1385","series-title":"Microbial Processes in the Sulfur Cycle Through Time","first-page":"5","author":"Tr\u00fcper","year":"1982"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1390","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cmet.2011.07.010","article-title":"Mutations in MTFMT underlie a human disorder of formylation causing impaired mitochondrial translation","volume":"14","author":"Tucker","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1395","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nature10866","article-title":"IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype","volume":"483","author":"Turcan","year":"2012","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1400","doi-asserted-by":"crossref","first-page":"E668","DOI":"10.1152\/ajpendo.00151.2011","article-title":"Knockout of the murine cysteine dioxygenase gene results in severe impairment in ability to synthesize taurine and an increased catabolism of cysteine to hydrogen sulfide","volume":"301","author":"Ueki","year":"2011","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1405","doi-asserted-by":"crossref","first-page":"e17828","DOI":"10.7554\/eLife.17828","article-title":"The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis","volume":"5","author":"Van Vranken","year":"2016","journal-title":"Elife"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1410","doi-asserted-by":"crossref","first-page":"40403","DOI":"10.1038\/srep40403","article-title":"Methionine residues around phosphorylation sites are preferentially oxidized in vivo under stress conditions","volume":"7","author":"Veredas","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1415","doi-asserted-by":"crossref","first-page":"35785","DOI":"10.1074\/jbc.M602799200","article-title":"A functional transsulfuration pathway in the brain links to glutathione homeostasis","volume":"281","author":"Vitvitsky","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1420","doi-asserted-by":"crossref","first-page":"32002","DOI":"10.1074\/jbc.M111.253344","article-title":"Taurine biosynthesis by neurons and astrocytes","volume":"286","author":"Vitvitsky","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1425","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cell.2016.07.002","article-title":"Mitochondria and cancer","volume":"166","author":"Vyas","year":"2016","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1430","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/ng1248","article-title":"Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation","volume":"35","author":"Wakabayashi","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1435","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.immuni.2011.09.021","article-title":"The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation","volume":"35","author":"Wang","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1440","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1186\/1471-2407-13-343","article-title":"Activation of SNAT1\/SLC38A1 in human breast cancer: correlation with p-Akt overexpression","volume":"13","author":"Wang","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1445","doi-asserted-by":"crossref","first-page":"78930","DOI":"10.18632\/oncotarget.20693","article-title":"Increased SNAT1 is a marker of human osteosarcoma and potential therapeutic target","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1450","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ccr.2010.01.020","article-title":"The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate","volume":"17","author":"Ward","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1455","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0180061","article-title":"Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells","volume":"12","author":"Ward","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1460","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0109245","article-title":"Cysteine transport through excitatory amino acid transporter 3 (EAAT3)","volume":"9","author":"Watts","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1465","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1476-4598-7-7","article-title":"Differential expression of metallothioneins (MTs) 1, 2, and 3 in response to zinc treatment in human prostate normal and malignant cells and tissues","volume":"7","author":"Wei","year":"2008","journal-title":"Mol. Cancer"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1470","doi-asserted-by":"crossref","first-page":"3598","DOI":"10.1172\/JCI58056","article-title":"Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice","volume":"121","author":"Wei","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1475","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.cmet.2015.01.019","article-title":"Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans","volume":"21","author":"Wei","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1480","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1073\/pnas.1003428107","article-title":"Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity","volume":"107","author":"Weinberg","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1485","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/sj.leu.2402476","article-title":"HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis","volume":"16","author":"Wong","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1490","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1074\/jbc.C400496200","article-title":"Reduction of cysteine sulfinic acid by sulfiredoxin is specific to 2-cys peroxiredoxins","volume":"280","author":"Woo","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1495","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1089\/acm.2007.0781","article-title":"Cysteine, sulfite, and glutamate toxicity: a cause of ALS?","volume":"14","author":"Woolsey","year":"2008","journal-title":"J. Altern. Complement. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1500","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1101\/gad.191056.112","article-title":"Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors","volume":"26","author":"Xiao","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1505","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.06.015","article-title":"N(6)-methyladenine DNA modification in the human genome","volume":"71","author":"Xiao","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1510","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.2337\/db16-0020","article-title":"Hydrogen sulfide induces Keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation","volume":"65","author":"Xie","year":"2016","journal-title":"Diabetes"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1515","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/ars.2010.3540","article-title":"S-glutathionylation: from molecular mechanisms to health outcomes","volume":"15","author":"Xiong","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1520","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ccr.2010.12.014","article-title":"Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases","volume":"19","author":"Xu","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1525","doi-asserted-by":"crossref","first-page":"2758","DOI":"10.1128\/MCB.01704-07","article-title":"Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity","volume":"28","author":"Yamamoto","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1530","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1083\/jcb.200702081","article-title":"Zinc is a novel intracellular second messenger","volume":"177","author":"Yamasaki","year":"2007","journal-title":"J. Cell Biol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1535","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1089\/ars.2012.4645","article-title":"Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2","volume":"18","author":"Yang","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1540","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nrc3895","article-title":"Dnmt3A in haematological malignancies","volume":"15","author":"Yang","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1545","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1016\/j.celrep.2016.09.067","article-title":"A Glo1-methylglyoxal pathway that is perturbed in maternal diabetes regulates embryonic and adult neural stem cell pools in murine offspring","volume":"17","author":"Yang","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1550","doi-asserted-by":"crossref","first-page":"83088","DOI":"10.18632\/oncotarget.20236","article-title":"Overexpression of carbonic anhydrase IX induces cell motility by activating matrix metalloproteinase-9 in human oral squamous cell carcinoma cells","volume":"8","author":"Yang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1555","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/path.2489","article-title":"Over-expression of metallothionein predicts chemoresistance in breast cancer","volume":"217","author":"Yap","year":"2009","journal-title":"J. Pathol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1560","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1074\/jbc.275.6.4251","article-title":"Modification defect at anticodon wobble nucleotide of mitochondrial tRNAs(Leu)(UUR) with pathogenic mutations of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes","volume":"275","author":"Yasukawa","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1565","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1136\/gutjnl-2016-313321","article-title":"Race-dependent association of sulfidogenic bacteria with colorectal cancer","volume":"66","author":"Yazici","year":"2017","journal-title":"Gut"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1570","doi-asserted-by":"crossref","first-page":"915","DOI":"10.4049\/jimmunol.1500729","article-title":"Targeting ornithine decarboxylase by alpha-difluoromethylornithine inhibits tumor growth by impairing myeloid-derived suppressor cells","volume":"196","author":"Ye","year":"2016","journal-title":"J. Immunol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1575","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2017.02.026","article-title":"A metabolic function for phospholipid and histone methylation","volume":"66","author":"Ye","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1580","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1002\/mnfr.201500031","article-title":"L-Cysteine metabolism and its nutritional implications","volume":"60","author":"Yin","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1585","first-page":"2583","article-title":"Anticancer efficacy in vivo and in vitro, synergy with 5-fluorouracil, and safety of recombinant methioninase","volume":"58","author":"Yoshioka","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1590","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1101\/gad.927301","article-title":"Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails","volume":"15","author":"Zhang","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1595","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.freeradbiomed.2005.11.005","article-title":"gamma-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE\/Nrf2 signaling in rat epithelial type II cells","volume":"40","author":"Zhang","year":"2006","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1600","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1021\/ar200202c","article-title":"Radical-mediated enzymatic methylation: a tale of two SAMS","volume":"45","author":"Zhang","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1605","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cell.2011.11.050","article-title":"Glycine decarboxylase activity drives non-small cell lung cancer tumor-initiating cells and tumorigenesis","volume":"148","author":"Zhang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1610","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1038\/ng.3610","article-title":"DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells","volume":"48","author":"Zhang","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1615","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3389\/fphar.2017.00608","article-title":"H2S-Induced sulfhydration: biological function and detection methodology","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1620","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00394-016-1322-x","article-title":"N-acetylcysteine attenuates intrauterine growth retardation-induced hepatic damage in suckling piglets by improving glutathione synthesis and cellular homeostasis","volume":"57","author":"Zhang","year":"2018","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1625","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.molcel.2012.08.010","article-title":"Endoplasmic reticulum thiol oxidase deficiency leads to ascorbic acid depletion and noncanonical scurvy in mice","volume":"48","author":"Zito","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/bs.ircmb.2019.05.001_bb1630","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2016.02.011","article-title":"Mitochondria and cancer","volume":"61","author":"Zong","year":"2016","journal-title":"Mol. Cell"}],"container-title":["International Review of Cell and Molecular Biology","Cellular Nutrient Utilization and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1937644819300590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1937644819300590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T18:32:25Z","timestamp":1761849145000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1937644819300590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9780128184066"],"references-count":326,"URL":"https:\/\/doi.org\/10.1016\/bs.ircmb.2019.05.001","relation":{},"ISSN":["1937-6448"],"issn-type":[{"value":"1937-6448","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}