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Physiol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0475","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1016\/j.cellsig.2007.05.016","article-title":"Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain","volume":"19","author":"Feng","year":"2007","journal-title":"Cell. 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A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0520","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1158\/1078-0432.CCR-06-2116","article-title":"Selective inhibition of ADAM metalloproteases as a novel approach for modulating ErbB pathways in cancer","volume":"13","author":"Fridman","year":"2007","journal-title":"Clin. 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Biol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0555","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.15252\/emmm.201403856","article-title":"A positive feedback loop between RIP3 and JNK controls non-alcoholic steatohepatitis","volume":"6","author":"Gautheron","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0560","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41467-017-00406-w","article-title":"Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis","volume":"8","author":"Geng","year":"2017","journal-title":"Nat. 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Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0605","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005337","article-title":"Pore-forming toxins induce macrophage necroptosis during acute bacterial pneumonia","volume":"11","author":"Gonz\u00e1lez-Juarbe","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0610","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev-physiol-021115-105439","article-title":"Enteroendocrine cells: chemosensors in the intestinal epithelium","volume":"78","author":"Gribble","year":"2016","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0615","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23968","article-title":"Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling","volume":"6","author":"Grieve","year":"2017","journal-title":"Elife"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0620","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/nature10400","article-title":"Caspase-8 regulates TNF-alpha-induced epithelial necroptosis and terminal ileitis","volume":"477","author":"G\u00fcnther","year":"2011","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0625","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.semcdb.2014.06.004","article-title":"Regulation and pathophysiological role of epithelial turnover in the gut","volume":"35","author":"G\u00fcnther","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0630","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.chom.2015.01.003","article-title":"Herpes simplex virus suppresses necroptosis in human cells","volume":"17","author":"Guo","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0635","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.molcel.2009.10.013","article-title":"Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction","volume":"36","author":"Haas","year":"2009","journal-title":"Mol. 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A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0665","first-page":"1539","article-title":"Low expression of mixed lineage kinase domain-like protein is associated with poor prognosis in ovarian cancer patients","volume":"6","author":"He","year":"2013","journal-title":"OncoTargets Ther."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0670","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1084\/jem.20160442","article-title":"Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice","volume":"214","author":"He","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0675","doi-asserted-by":"crossref","first-page":"681","DOI":"10.3109\/00365521.2014.898326","article-title":"Surface area of the digestive tract\u2014revisited","volume":"49","author":"Helander","year":"2014","journal-title":"Scand. J. 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A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0695","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4049\/jimmunol.1402070","article-title":"The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity","volume":"194","author":"Hoffmann","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0700","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/82732","article-title":"Fas triggers an alternative, caspase-8-independent cell death pathway using the kinase RIP as effector molecule","volume":"1","author":"Holler","year":"2000","journal-title":"Nat. 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Dyn."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0760","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.molcel.2017.05.003","article-title":"MK2 phosphorylates ripk1 to prevent TNF-induced cell death","volume":"66","author":"Jaco","year":"2017","journal-title":"Mol. 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Rev. Physiol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0785","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature11582","article-title":"Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease","volume":"491","author":"Jostins","year":"2012","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0790","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.immuni.2013.02.003","article-title":"Necroptosis: the release of damage-associated molecular patterns and its physiological relevance","volume":"38","author":"Kaczmarek","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0795","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature09857","article-title":"RIP3 mediates the embryonic lethality of caspase-8-deficient mice","volume":"471","author":"Kaiser","year":"2011","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0800","doi-asserted-by":"crossref","first-page":"31268","DOI":"10.1074\/jbc.M113.462341","article-title":"Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL","volume":"288","author":"Kaiser","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0805","doi-asserted-by":"crossref","first-page":"7753","DOI":"10.1073\/pnas.1401857111","article-title":"RIP1 suppresses innate immune necrotic as well as apoptotic cell death during mammalian parturition","volume":"111","author":"Kaiser","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0810","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/sj.cdd.4401051","article-title":"Tipping the balance between necrosis and apoptosis in human and murine cells treated with interferon and dsRNA","volume":"9","author":"Kalai","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0815","article-title":"TRAF2 inhibits TRAIL- and CD95L-induced apoptosis and necroptosis","volume":"5","author":"Karl","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0820","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1083\/jcb.143.5.1353","article-title":"Caspase-independent cell killing by Fas-associated protein with death domain","volume":"143","author":"Kawahara","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0825","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1042\/BJ20091611","article-title":"The cytoplasmic domains of TNFalpha-converting enzyme (TACE\/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding","volume":"428","author":"Killock","year":"2010","journal-title":"Biochem. J."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0830","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.238","article-title":"Caspase blockade induces RIP3-mediated programmed necrosis in Toll-like receptor-activated microglia","volume":"4","author":"Kim","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0835","doi-asserted-by":"crossref","first-page":"495817","DOI":"10.1155\/2014\/495817","article-title":"Necrostatin-1 reduces neurovascular injury after intracerebral hemorrhage","volume":"2014","author":"King","year":"2014","journal-title":"Int. J. 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Immunol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0895","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1091\/mbc.e08-11-1135","article-title":"ADAMs 10 and 17 represent differentially regulated components of a general shedding machinery for membrane proteins such as transforming growth factor alpha, L-selectin, and tumor necrosis factor alpha","volume":"20","author":"Le Gall","year":"2009","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0900","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/s41556-019-0356-8","article-title":"The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome","volume":"21","author":"Lee","year":"2019","journal-title":"Nat. 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J."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0910","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ebiom.2016.06.002","article-title":"ADAM30 downregulates APP-linked defects through cathepsin D activation in Alzheimer's disease","volume":"9","author":"Letronne","year":"2016","journal-title":"EBioMedicine"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0915","doi-asserted-by":"crossref","first-page":"10519","DOI":"10.1074\/jbc.275.14.10519","article-title":"Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation","volume":"275","author":"Lewis","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0920","doi-asserted-by":"crossref","first-page":"13636","DOI":"10.1074\/jbc.M600620200","article-title":"Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation","volume":"281","author":"Li","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0925","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.cell.2012.06.019","article-title":"The RIP1\/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis","volume":"150","author":"Li","year":"2012","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0930","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.3892\/mmr.2015.4011","article-title":"Knockdown of ADAM10 inhibits migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"12","author":"Li","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0935","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1073\/pnas.1505244112","article-title":"A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis","volume":"112","author":"Li","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0940","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1177\/1533034616655909","article-title":"Association of mixed lineage kinase domain-like protein expression with prognosis in patients with colon cancer","volume":"16","author":"Li","year":"2017","journal-title":"Technol. Cancer Res. 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Drugs Ther."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0955","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.1101\/gad.13.19.2514","article-title":"Cleavage of the death domain kinase RIP by Caspase-8 prompts TNF-induced apoptosis","volume":"13","author":"Lin","year":"1999","journal-title":"Genes Dev."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0960","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.celrep.2012.12.012","article-title":"A role of RIP3-mediated macrophage necrosis in atherosclerosis development","volume":"3","author":"Lin","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0965","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature20558","article-title":"RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation","volume":"540","author":"Lin","year":"2016","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0970","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2119\/molmed.2011.00423","article-title":"Dichotomy between RIP1- and RIP3-mediated necroptosis in tumor necrosis factor-alpha-induced shock","volume":"18","author":"Linkermann","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0975","doi-asserted-by":"crossref","first-page":"12024","DOI":"10.1073\/pnas.1305538110","article-title":"Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury","volume":"110","author":"Linkermann","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0980","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/ng.3359","article-title":"Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations","volume":"47","author":"Liu","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0985","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1179\/2045772314Y.0000000224","article-title":"Necroptosis, a novel type of programmed cell death, contributes to early neural cells damage after spinal cord injury in adult mice","volume":"38","author":"Liu","year":"2015","journal-title":"J. Spinal Cord Med."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0990","first-page":"3174","article-title":"Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice","volume":"5","author":"Liu","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb0995","doi-asserted-by":"crossref","first-page":"E7450","DOI":"10.1073\/pnas.1707531114","article-title":"MLKL forms disulfide bond-dependent amyloid-like polymers to induce necroptosis","volume":"114","author":"Liu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1000","first-page":"E1475","article-title":"RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism","volume":"115","author":"Liu","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1005","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.7150\/thno.32126","article-title":"RIP3 promotes colitis-associated colorectal cancer by controlling tumor cell proliferation and CXCL1-induced immune suppression","volume":"9","author":"Liu","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1010","doi-asserted-by":"crossref","first-page":"35067","DOI":"10.1038\/srep35067","article-title":"Control of ADAM17 activity by regulation of its cellular localisation","volume":"6","author":"Lorenzen","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1015","doi-asserted-by":"crossref","first-page":"15312","DOI":"10.1073\/pnas.1102779108","article-title":"Complementary roles of Fas-associated death domain (FADD) and receptor interacting protein kinase-3 (RIPK3) in T-cell homeostasis and antiviral immunity","volume":"108","author":"Lu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1020","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/cvr\/cvu146","article-title":"RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction","volume":"103","author":"Luedde","year":"2014","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1025","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.15252\/embj.201796476","article-title":"Sensing of viral and endogenous RNA by ZBP1\/DAI induces necroptosis","volume":"36","author":"Maelfait","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1030","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10208","article-title":"Intestinal homeostasis and its breakdown in inflammatory bowel disease","volume":"474","author":"Maloy","year":"2011","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1035","doi-asserted-by":"crossref","first-page":"10376","DOI":"10.1074\/jbc.M109.055947","article-title":"An arginine stretch limits ADAM10 exit from the endoplasmic reticulum","volume":"285","author":"Marcello","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1040","doi-asserted-by":"crossref","first-page":"11433","DOI":"10.1073\/pnas.1302553110","article-title":"iRhom2 controls the substrate selectivity of stimulated ADAM17-dependent ectodomain shedding","volume":"110","author":"Maretzky","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1045","doi-asserted-by":"crossref","first-page":"8093","DOI":"10.1073\/pnas.94.15.8093","article-title":"Characterization of tumor necrosis factor-deficient mice","volume":"94","author":"Marino","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1050","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-3-030-02771-1_8","article-title":"Anti-EGFR therapy to treat metastatic colorectal cancer: not for all","volume":"1110","author":"Martins","year":"2018","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1055","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1515\/BC.2011.080","article-title":"Lack of ADAM15 in mice is associated with increased osteoblast function and bone mass","volume":"392","author":"Marzia","year":"2011","journal-title":"Biol. Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1060","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1210\/en.2004-1082","article-title":"Role of meltrin {alpha} (ADAM12) in obesity induced by high-fat diet","volume":"146","author":"Masaki","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1065","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1084\/jem.20170558","article-title":"Autophagy protein ATG16L1 prevents necroptosis in the intestinal epithelium","volume":"214","author":"Matsuzawa-Ishimoto","year":"2017","journal-title":"J. Exp. Med."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1070","doi-asserted-by":"crossref","first-page":"4728","DOI":"10.1158\/0008-5472.CAN-04-4449","article-title":"A secreted form of ADAM9 promotes carcinoma invasion through tumor-stromal interactions","volume":"65","author":"Mazzocca","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1075","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1038\/cdd.2012.59","article-title":"cIAP1 and cIAP2 limit macrophage necroptosis by inhibiting Rip1 and Rip3 activation","volume":"19","author":"McComb","year":"2012","journal-title":"Cell Death Differ."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1080","doi-asserted-by":"crossref","first-page":"E3206","DOI":"10.1073\/pnas.1407068111","article-title":"Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages","volume":"111","author":"McComb","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1085","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.4049\/jimmunol.1303380","article-title":"Cathepsins limit macrophage necroptosis through cleavage of Rip1 kinase","volume":"192","author":"McComb","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1090","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.virol.2003.07.003","article-title":"Differential function and expression of the viral inhibitor of caspase 8-induced apoptosis (vICA) and the viral mitochondria-localized inhibitor of apoptosis (vMIA) cell death suppressors conserved in primate and rodent cytomegaloviruses","volume":"316","author":"McCormick","year":"2003","journal-title":"Virology"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1095","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1126\/science.1214448","article-title":"iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS","volume":"335","author":"McIlwain","year":"2012","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1100","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.chembiol.2019.03.010","article-title":"Direct activation of human MLKL by a select repertoire of inositol phosphate metabolites","volume":"26","author":"McNamara","year":"2019","journal-title":"Cell Chem. 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Biol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1165","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.immuni.2014.09.016","article-title":"The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair","volume":"41","author":"Moriwaki","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1170","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/0959-8049(95)00181-H","article-title":"ApcMin: a mouse model for intestinal and mammary tumorigenesis","volume":"31A","author":"Moser","year":"1995","journal-title":"Eur. J. 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Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1185","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2012.201","article-title":"TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1","volume":"4","author":"Moujalled","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1190","doi-asserted-by":"crossref","first-page":"17431","DOI":"10.18632\/oncotarget.7836","article-title":"A disintegrin and metalloprotease 10 (ADAM10) is a central regulator of murine liver tissue homeostasis","volume":"7","author":"M\u00fcller","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1195","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/bjc.2015.288","article-title":"ADAM10: a new player in breast cancer progression?","volume":"113","author":"Mullooly","year":"2015","journal-title":"Br. J. 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A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1210","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/cdd.2013.109","article-title":"Programmed necrosis, not apoptosis, is a key mediator of cell loss and DAMP-mediated inflammation in dsRNA-induced retinal degeneration","volume":"21","author":"Murakami","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1215","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/nrc2459","article-title":"The ADAMs: signalling scissors in the tumour microenvironment","volume":"8","author":"Murphy","year":"2008","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1220","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1172\/JCI42686","article-title":"Ectodomain shedding of EGFR ligands and TNFR1 dictates hepatocyte apoptosis during fulminant hepatitis in mice","volume":"120","author":"Murthy","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1517\/13543770903465157","article-title":"Novel TACE inhibitors in drug discovery: a review of patented compounds","volume":"20","author":"Murumkar","year":"2010","journal-title":"Expert Opin. Ther. Pat."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1230","doi-asserted-by":"crossref","first-page":"250762","DOI":"10.1155\/2015\/250762","article-title":"Apoptosis, necrosis, and necroptosis in the gut and intestinal homeostasis","volume":"2015","author":"Negroni","year":"2015","journal-title":"Mediators Inflamm."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1235","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/j.dld.2017.08.017","article-title":"RIP3 AND pMLKL promote necroptosis-induced inflammation and alter membrane permeability in intestinal epithelial cells","volume":"49","author":"Negroni","year":"2017","journal-title":"Dig. 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Biochem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1245","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1038\/cdd.2016.46","article-title":"RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury","volume":"23","author":"Newton","year":"2016","journal-title":"Cell Death Differ."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1250","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nature20559","article-title":"RIPK1 inhibits ZBP1-driven necroptosis during development","volume":"540","author":"Newton","year":"2016","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1255","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41586-019-1548-x","article-title":"Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis","volume":"574","author":"Newton","year":"2019","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1260","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1161\/ATVBAHA.116.308682","article-title":"Adam17 deficiency promotes atherosclerosis by enhanced TNFR2 signaling in mice","volume":"37","author":"Nicolaou","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1265","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev-physiol-030212-183741","article-title":"Notch in the intestine: regulation of homeostasis and pathogenesis","volume":"75","author":"Noah","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1270","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1158\/0008-5472.CAN-13-1283","article-title":"Accumulation of cytosolic calcium induces necroptotic cell death in human neuroblastoma","volume":"74","author":"Nomura","year":"2014","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1275","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature09852","article-title":"Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis","volume":"471","author":"Oberst","year":"2011","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1280","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1038\/ncb2362","article-title":"Caspase 8 inhibits programmed necrosis by processing CYLD","volume":"13","author":"O'Donnell","year":"2011","journal-title":"Nat. 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Cardiol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1290","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1016\/j.celrep.2015.02.051","article-title":"Activation of necroptosis in multiple sclerosis","volume":"10","author":"Ofengeim","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1295","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/sj.embor.7400731","article-title":"The gut flora as a forgotten organ","volume":"7","author":"O'Hara","year":"2006","journal-title":"EMBO Rep."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1300","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/ijc.21324","article-title":"ADAM28 is overexpressed in human non-small cell lung carcinomas and correlates with cell proliferation and lymph node metastasis","volume":"118","author":"Ohtsuka","year":"2006","journal-title":"Int. J. Cancer"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1305","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.35032","article-title":"iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom\/TACE","volume":"7","author":"Oikonomidi","year":"2018","journal-title":"Elife"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1310","doi-asserted-by":"crossref","first-page":"11635","DOI":"10.1074\/jbc.M115.646042","article-title":"Suppression of RIP3-dependent necroptosis by human cytomegalovirus","volume":"290","author":"Omoto","year":"2015","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1315","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1038\/ni.3172","article-title":"The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis","volume":"16","author":"Onizawa","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1320","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.clim.2016.05.011","article-title":"Heightened cleavage of Axl receptor tyrosine kinase by ADAM metalloproteases may contribute to disease pathogenesis in SLE","volume":"169","author":"Orme","year":"2016","journal-title":"Clin. Immunol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1325","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/cdd.2014.76","article-title":"RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis","volume":"21","author":"Orozco","year":"2014","journal-title":"Cell Death Differ."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1330","doi-asserted-by":"crossref","first-page":"13034","DOI":"10.1073\/pnas.1005997107","article-title":"Fas-associated death domain (FADD) is a negative regulator of T-cell receptor-mediated necroptosis","volume":"107","author":"Osborn","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1335","article-title":"Necroptosis takes place in human immunodeficiency virus type-1 (HIV-1)-infected CD4+ T lymphocytes","volume":"9","author":"Pan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1340","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/cbf.2972","article-title":"Distinctive roles of receptor-interacting protein kinases 1 and 3 in caspase-independent cell death of L929","volume":"32","author":"Park","year":"2014","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1345","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.ajhg.2009.04.005","article-title":"Loss of the metalloprotease ADAM9 leads to cone-rod dystrophy in humans and retinal degeneration in mice","volume":"84","author":"Parry","year":"2009","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1350","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature14191","article-title":"Necroptosis and its role in inflammation","volume":"517","author":"Pasparakis","year":"2015","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1355","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1084\/jem.184.4.1397","article-title":"Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response","volume":"184","author":"Pasparakis","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1360","doi-asserted-by":"crossref","DOI":"10.1111\/cmi.12750","article-title":"Down the rabbit hole: is necroptosis truly an innate response to infection?","volume":"19","author":"Pearson","year":"2017","journal-title":"Cell. Microbiol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1365","doi-asserted-by":"crossref","first-page":"16258","DOI":"10.1038\/nmicrobiol.2016.258","article-title":"EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation","volume":"2","author":"Pearson","year":"2017","journal-title":"Nat. Microbiol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1370","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.282.5392.1281","article-title":"An essential role for ectodomain shedding in mammalian development","volume":"282","author":"Peschon","year":"1998","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1375","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1038\/cdd.2015.35","article-title":"TRAF2 is a biologically important necroptosis suppressor","volume":"22","author":"Petersen","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1380","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1038\/s41467-018-04714-7","article-title":"Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis","volume":"9","author":"Petrie","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1385","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.tibs.2018.11.002","article-title":"The structural basis of necroptotic cell death signaling","volume":"44","author":"Petrie","year":"2019","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1390","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/ajg.2013.403","article-title":"Necroptosis is active in children with inflammatory bowel disease and contributes to heighten intestinal inflammation","volume":"109","author":"Pierdomenico","year":"2014","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1395","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/ni.1639","article-title":"The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors","volume":"9","author":"Pobezinskaya","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1400","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.4049\/jimmunol.1400590","article-title":"Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo","volume":"193","author":"Polykratis","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1405","doi-asserted-by":"crossref","first-page":"134","DOI":"10.3390\/toxins9040134","article-title":"Proteolysis in Helicobacter pylori-Induced Gastric Cancer","volume":"9","author":"Posselt","year":"2017","journal-title":"Toxins (Basel)"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1410","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1172\/JCI20864","article-title":"A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model","volume":"113","author":"Postina","year":"2004","journal-title":"J. Clin. Invest."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1415","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1080\/14712598.2016.1203897","article-title":"Considerations, challenges and future of anti-TNF therapy in treating inflammatory bowel disease","volume":"16","author":"Pouillon","year":"2016","journal-title":"Expert Opin. Biol. Ther."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1420","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1007\/s00018-012-0960-2","article-title":"Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10","volume":"69","author":"Prox","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1425","first-page":"543","article-title":"Necrostatin-1 inhibits the degeneration of neural cells induced by aluminum exposure","volume":"31","author":"Qinli","year":"2013","journal-title":"Restor. Neurol. Neurosci."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1430","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.neuron.2014.01.011","article-title":"Necroptosis drives motor neuron death in models of both sporadic and familial ALS","volume":"81","author":"Re","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1435","doi-asserted-by":"crossref","first-page":"14608","DOI":"10.1074\/jbc.275.19.14608","article-title":"Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme","volume":"275","author":"Reddy","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1440","first-page":"1223","article-title":"Activation of Notch signaling in human colon adenocarcinoma","volume":"33","author":"Reedijk","year":"2008","journal-title":"Int. J. 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Rev."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1545","doi-asserted-by":"crossref","first-page":"17458","DOI":"10.1523\/JNEUROSCI.1380-13.2013","article-title":"Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein","volume":"33","author":"Sato","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1550","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00018-019-03184-4","article-title":"Degradome of soluble ADAM10 and ADAM17 metalloproteases","volume":"77","author":"Scharfenberg","year":"2020","journal-title":"Cell. Mol. 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Biophys. Res. Commun."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1570","doi-asserted-by":"crossref","first-page":"48210","DOI":"10.1074\/jbc.M203355200","article-title":"The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion","volume":"277","author":"Schlomann","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1575","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1084\/jem.20171696","article-title":"ADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling","volume":"215","author":"Schmidt","year":"2018","journal-title":"J. Exp. Med."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1580","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/cdd.2016.153","article-title":"Induction of necroptotic cell death by viral activation of the RIG-I or STING pathway","volume":"24","author":"Schock","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1585","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.3390\/cancers11111736","article-title":"ADAM17 activity and IL-6 trans-signaling in inflammation and cancer","volume":"11","author":"Schumacher","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1590","doi-asserted-by":"crossref","first-page":"12396","DOI":"10.1073\/pnas.1407597111","article-title":"Microbial-induced meprin beta cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus","volume":"111","author":"Sch\u00fctte","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1595","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1016\/j.bbamcr.2013.10.005","article-title":"Short-term TNFalpha shedding is independent of cytoplasmic phosphorylation or furin cleavage of ADAM17","volume":"1833","author":"Schwarz","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1600","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1074\/jbc.M113.536847","article-title":"Polo-like kinase 2, a novel ADAM17 signaling component, regulates tumor necrosis factor alpha ectodomain shedding","volume":"289","author":"Schwarz","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1605","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ncb3314","article-title":"CHIP controls necroptosis through ubiquitylation- and lysosome-dependent degradation of RIPK3","volume":"18","author":"Seo","year":"2016","journal-title":"Nat. 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Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1625","doi-asserted-by":"crossref","first-page":"13973","DOI":"10.1073\/pnas.93.24.13973","article-title":"The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex","volume":"93","author":"Shu","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1630","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/j.1432-0436.2007.00238.x","article-title":"The epidermal growth factor receptor: from development to tumorigenesis","volume":"75","author":"Sibilia","year":"2007","journal-title":"Differentiation"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1635","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3322\/caac.21395","article-title":"Colorectal cancer statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA-Cancer J. Clin."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1640","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/neu.1064","article-title":"Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques","volume":"49","author":"Skovronsky","year":"2001","journal-title":"J. Neurobiol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1645","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s10557-007-6035-1","article-title":"Necrostatin: a potentially novel cardioprotective agent?","volume":"21","author":"Smith","year":"2007","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1650","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1126\/science.1133501","article-title":"Neuroscience. 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Cell Sci."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1665","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1478-811X-11-76","article-title":"The proteases HtrA2\/Omi and UCH-L1 regulate TNF-induced necroptosis","volume":"11","author":"Sosna","year":"2013","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1670","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1128\/MCB.00941-15","article-title":"Differences and similarities in TRAIL- and TNF-mediated necroptotic signaling in cancer cells","volume":"36","author":"Sosna","year":"2016","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1675","doi-asserted-by":"crossref","first-page":"C183","DOI":"10.1152\/ajpcell.1991.260.2.C183","article-title":"Functional biology of intestinal goblet cells","volume":"260","author":"Specian","year":"1991","journal-title":"Am. J. Physiol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1680","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.15252\/embr.201743947","article-title":"Murine cytomegalovirus IE3-dependent transcription is required for DAI\/ZBP1-mediated necroptosis","volume":"18","author":"Sridharan","year":"2017","journal-title":"EMBO Rep."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1685","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1053\/j.gastro.2017.03.053","article-title":"EGFR in tumor-associated myeloid cells promotes development of colorectal cancer in mice and associates with outcomes of patients","volume":"153","author":"Srivatsa","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1690","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/pro.5560040502","article-title":"The metzincins\u2014topological and sequential relations between the astacins, adamalysins, serralysins, and matrixins (collagenases) define a superfamily of zinc-peptidases","volume":"4","author":"St\u00f6cker","year":"1995","journal-title":"Protein Sci."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1695","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1042\/BJ20051013","article-title":"A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44","volume":"393","author":"Stoeck","year":"2006","journal-title":"Biochem. J."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1700","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1084\/jem.192.5.601","article-title":"Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death","volume":"192","author":"Strelow","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1705","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nature19076","article-title":"Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis","volume":"536","author":"Strilic","year":"2016","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1710","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/leu.2011.130","article-title":"Redundancy and specificity of the metalloprotease system mediating oncogenic NOTCH1 activation in T-ALL","volume":"25","author":"Sulis","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1715","doi-asserted-by":"crossref","first-page":"9505","DOI":"10.1074\/jbc.M109488200","article-title":"Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3","volume":"277","author":"Sun","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1720","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.cell.2011.11.031","article-title":"Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase","volume":"148","author":"Sun","year":"2012","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1725","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/nature13706","article-title":"RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis","volume":"513","author":"Takahashi","year":"2014","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1730","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.semcdb.2008.07.009","article-title":"Three-dimensional domain architecture of the ADAM family proteinases","volume":"20","author":"Takeda","year":"2009","journal-title":"Semin. Cell Dev. 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A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1790","doi-asserted-by":"crossref","first-page":"572025","DOI":"10.1155\/2014\/572025","article-title":"ADAM metallopeptidase domain 33 (ADAM33): a promising target for asthma","volume":"2014","author":"Tripathi","year":"2014","journal-title":"Mediators Inflamm."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1795","doi-asserted-by":"crossref","first-page":"S61","DOI":"10.1016\/S0016-5085(12)60237-6","article-title":"Intestinal cell responses in different injury\/regeneration models are differentially dependent on ADAM17","volume":"142","author":"Tsai","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1800","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/S0016-5085(13)60182-1","article-title":"Cell-autonomous ADAM10 signaling is required for adenoma initiation after APC mutation","volume":"144","author":"Tsai","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1805","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1053\/j.gastro.2014.07.003","article-title":"ADAM10 regulates Notch function in intestinal stem cells of mice","volume":"147","author":"Tsai","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1810","doi-asserted-by":"crossref","first-page":"44151","DOI":"10.18632\/oncotarget.6629","article-title":"Cytokine secretion and NK cell activity in human ADAM17 deficiency","volume":"6","author":"Tsukerman","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1815","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1021\/pr401135u","article-title":"LC-MS based cleavage site profiling of the proteases ADAM10 and ADAM17 using proteome-derived peptide libraries","volume":"13","author":"Tucher","year":"2014","journal-title":"J. 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Biol. Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1895","first-page":"72","article-title":"Influence of environmental factors in the development and outcomes of inflammatory bowel disease","volume":"15","author":"Vedamurthy","year":"2019","journal-title":"Gastroenterol. Hepatol. (N. Y.)"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1900","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1006\/cyto.1997.0252","article-title":"Tumour necrosis factor-induced necrosis versus anti-Fas-induced apoptosis in L929 cells","volume":"9","author":"Vercammen","year":"1997","journal-title":"Cytokine"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1905","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1084\/jem.187.9.1477","article-title":"Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor","volume":"187","author":"Vercammen","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1910","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1084\/jem.188.5.919","article-title":"Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways","volume":"188","author":"Vercammen","year":"1998","journal-title":"J. Exp. Med."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1915","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nm.3449","article-title":"RIPK3 as a potential therapeutic target for Gaucher's disease","volume":"20","author":"Vitner","year":"2014","journal-title":"Nat. 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Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1935","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00281-009-0161-8","article-title":"Colitis-associated cancer: the role of T cells in tumor development","volume":"31","author":"Waldner","year":"2009","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1940","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2008.03.036","article-title":"TNF-alpha induces two distinct caspase-8 activation pathways","volume":"133","author":"Wang","year":"2008","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1945","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.molcel.2014.03.003","article-title":"Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3","volume":"54","author":"Wang","year":"2014","journal-title":"Mol. 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Sci."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1970","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1242\/dev.076398","article-title":"Ectodomain shedding and ADAMs in development","volume":"139","author":"Weber","year":"2012","journal-title":"Development"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1975","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.celrep.2013.08.045","article-title":"Protective roles for caspase-8 and cFLIP in adult homeostasis","volume":"5","author":"Weinlich","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1980","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature10273","article-title":"FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation","volume":"477","author":"Welz","year":"2011","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb1985","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/jcmm.12987","article-title":"Necroptosis is a key mediator of enterocytes loss in intestinal ischaemia\/reperfusion injury","volume":"21","author":"Wen","year":"2017","journal-title":"J. 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Gaz."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2010","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/sj.cdd.4401107","article-title":"Death of HT29 adenocarcinoma cells induced by TNF family receptor activation is caspase-independent and displays features of both apoptosis and necrosis","volume":"9","author":"Wilson","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2015","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1053\/j.gastro.2017.07.036","article-title":"Inhibition of aurora kinase A induces necroptosis in pancreatic carcinoma","volume":"153","author":"Xie","year":"2017","journal-title":"Gastroenterology"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2020","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.molcel.2010.01.034","article-title":"Direct activation of TACE-mediated ectodomain shedding by p38 MAP kinase regulates EGF receptor-dependent cell proliferation","volume":"37","author":"Xu","year":"2010","journal-title":"Mol. 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Funct."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2040","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1038\/377652a0","article-title":"A metalloprotease-disintegrin participating in myoblast fusion","volume":"377","author":"Yagami-Hiromasa","year":"1995","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2045","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1349-7006.2006.00348.x","article-title":"Multistep carcinogenesis of the colon in Apc(Min\/+) mouse","volume":"98","author":"Yamada","year":"2007","journal-title":"Cancer Sci."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2050","doi-asserted-by":"crossref","first-page":"30742","DOI":"10.1074\/jbc.M113.492397","article-title":"A Lactobacillus rhamnosus GG-derived soluble protein, p40, stimulates ligand release from intestinal epithelial cells to transactivate epidermal growth factor receptor","volume":"288","author":"Yan","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2055","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1189\/jlb.3A0515-207R","article-title":"ADAM17 controls IL-6 signaling by cleavage of the murine IL-6Ralpha from the cell surface of leukocytes during inflammatory responses","volume":"99","author":"Yan","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2060","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/cne.20659","article-title":"A disintegrin and metalloprotease 21 (ADAM21) is associated with neurogenesis and axonal growth in developing and adult rodent CNS","volume":"490","author":"Yang","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2065","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11060-011-0557-x","article-title":"L1 stimulation of human glioma cell motility correlates with FAK activation","volume":"105","author":"Yang","year":"2011","journal-title":"J. Neurooncol"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2070","doi-asserted-by":"crossref","first-page":"2583","DOI":"10.1038\/ncomms3583","article-title":"Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-alpha","volume":"4","author":"Yang","year":"2013","journal-title":"Nat. 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A."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2002711","article-title":"Phosphatidylserine externalization, \u201cnecroptotic bodies\u201d release, and phagocytosis during necroptosis","volume":"15","author":"Zargarian","year":"2017","journal-title":"PLoS Biol."},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2110","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1126\/science.1172308","article-title":"RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis","volume":"325","author":"Zhang","year":"2009","journal-title":"Science"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2115","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/labinvest.2011.192","article-title":"ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival","volume":"92","author":"Zhang","year":"2012","journal-title":"Lab. 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(Lond.)"},{"key":"10.1016\/bs.ircmb.2020.02.001_bb2145","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.molimm.2019.01.018","article-title":"MLKL deficiency inhibits DSS-induced colitis independent of intestinal microbiota","volume":"107","author":"Zhang","year":"2019","journal-title":"Mol. 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