{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T10:12:52Z","timestamp":1783678372478,"version":"3.55.0"},"reference-count":74,"publisher":"Elsevier","isbn-type":[{"value":"9780443161346","type":"print"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["CUP J33C22002920006"],"award-info":[{"award-number":["CUP J33C22002920006"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PNRR - M4C2-I1"],"award-info":[{"award-number":["PNRR - M4C2-I1"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/bs.ircmb.2023.07.004","type":"book-chapter","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T03:00:53Z","timestamp":1691463653000},"page":"99-111","source":"Crossref","is-referenced-by-count":9,"title":["Settling the uncertainty about unconventional circulating tumor cells: Epithelial-to-mesenchymal transition, cell fusion and trogocytosis"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.ircmb.2023.07.004_bib1","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.cell.2014.07.013","article-title":"Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis","volume":"158","author":"Aceto","year":"2014","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib2","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1158\/1055-9965.EPI-15-1221","article-title":"Circulating cancer-associated macrophage-like cells differentiate malignant breast cancer and benign breast conditions","volume":"25","author":"Adams","year":"2016","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib3","doi-asserted-by":"crossref","first-page":"3514","DOI":"10.1073\/pnas.1320198111","article-title":"Circulating giant macrophages as a potential biomarker of solid tumors","volume":"111","author":"Adams","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib4","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1158\/2159-8290.CD-20-1311","article-title":"Liquid biopsy: From discovery to clinical application","volume":"11","author":"Alix-Panabi\u00e8res","year":"2021","journal-title":"Cancer Discov."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib5","doi-asserted-by":"crossref","first-page":"6897","DOI":"10.1158\/1078-0432.CCR-04-0378","article-title":"Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases","volume":"10","author":"Allard","year":"2004","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib6","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1158\/1541-7786.MCR-10-0490","article-title":"Circulating tumor cells from patients with advanced prostate and breast cancer display both epithelial and mesenchymal markers","volume":"9","author":"Armstrong","year":"2011","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib7","article-title":"A case of cancer in which cells similar to those in the tumours were seen in the blood after death. [WWW Document]","author":"Ashworth","year":"1869","journal-title":"Med. J. Aust."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib8","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nbt.2576","article-title":"Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay","volume":"31","author":"Baccelli","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1001\/jamaoncol.2020.5660","article-title":"Efficacy of circulating tumor cell count-driven vs clinician-driven first-line therapy choice in hormone receptor-positive, ERBB2-negative metastatic breast cancer: The STIC CTC Randomized Clinical Trial","volume":"7","author":"Bidard","year":"2021","journal-title":"JAMA Oncol."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13058-016-0687-3","article-title":"In patients with metastatic breast cancer the identification of circulating tumor cells in epithelial-to-mesenchymal transition is associated with a poor prognosis","volume":"18","author":"Bulfoni","year":"2016","journal-title":"Breast Cancer Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib11","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/ijc.11210","article-title":"Spontaneously formed tumorigenic hybrids of Meth A sarcoma cells and macrophages in vivo","volume":"106","author":"Busund","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib12","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1038\/s41416-020-01227-3","article-title":"Clinical utility of circulating tumour cell-based monitoring of late-line chemotherapy for metastatic breast cancer: the randomised CirCe01 trial","volume":"124","author":"Cabel","year":"2021","journal-title":"Br. J. Cancer"},{"issue":"129","key":"10.1016\/bs.ircmb.2023.07.004_bib13","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1038\/nm963","article-title":"Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates","volume":"9","author":"Camargo","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib14","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1200\/JCO.2007.15.8923","article-title":"Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer","volume":"26","author":"Cohen","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib15","doi-asserted-by":"crossref","first-page":"2556","DOI":"10.1073\/pnas.69.9.2556","article-title":"Antigen-binding specificity of isolated cell-surface immunoglobulin from thymus cells activated to histocompatibility antigens","volume":"69","author":"Cone","year":"1972","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13046-022-02263-y","article-title":"An organoid model of colorectal circulating tumor cells with stem cell features, hybrid EMT state and distinctive therapy response profile","volume":"41","author":"De Angelis","year":"2022","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/BF00047690","article-title":"Nonmetastatic tumor cells acquire metastatic properties following somatic hybridization with normal cells","volume":"3","author":"De Baetselier","year":"1984","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib18","doi-asserted-by":"crossref","first-page":"6302","DOI":"10.1158\/1078-0432.CCR-08-0872","article-title":"Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer","volume":"14","author":"De Bono","year":"2008","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib19","doi-asserted-by":"crossref","unstructured":"Gallerani, G., Bonaf\u00e8, M., Fabbri Istituto Scientico Romagnolo, F., 2021. CNA profiling of single CTCs in locally advanced esophageal cancer patients during therapy highlights unexplored molecular pathways.","DOI":"10.21203\/rs.3.rs-850357\/v1"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/sciadv.aat7828","article-title":"Cell fusion potentiates tumor heterogeneity and reveals circulating hybrid cells that correlate with stage and survival","volume":"4","author":"Gast","year":"2018","journal-title":"Sci. Adv."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib21","doi-asserted-by":"crossref","first-page":"6415","DOI":"10.1158\/0008-5472.CAN-16-3521","article-title":"Survival outcomes in cancer patients predicted by a partial EMT gene expression scoring metric","volume":"77","author":"George","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/250649a0","article-title":"In vivo hybridisation of human tumour and normal hamster cells","volume":"250","author":"Goldenberg","year":"1974","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib23","first-page":"12","article-title":"Circulating tumour cells escape from EpCAM-based detection due to epithelial-to-mesenchymal transition","author":"Gorges","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib24","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib25","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1158\/1078-0432.CCR-05-2821","article-title":"Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival","volume":"12","author":"Hayes","year":"2006","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s12967-018-1663-8","article-title":"Analysis of circulating tumour cell and the epithelial mesenchymal transition (EMT) status during eribulin-based treatment in 22 patients with metastatic breast cancer: a pilot study","volume":"16","author":"Horimoto","year":"2018","journal-title":"J. Transl. Med."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib27","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.ajpath.2010.12.003","article-title":"Circulating tumor cells as a window on metastasis biology in lung cancer","volume":"178","author":"Hou","year":"2011","journal-title":"Am. J. Pathol."},{"issue":"286","key":"10.1016\/bs.ircmb.2023.07.004_bib28","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1126\/science.286.5441.952","article-title":"TCR-mediated internalization of peptide-MHC complexes acquired by T cells","volume":"1979","author":"Huang","year":"1999","journal-title":"Science (New York, N. Y. )"},{"issue":"5 10","key":"10.1016\/bs.ircmb.2023.07.004_bib29","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/ncb1720","article-title":"Extensive fusion of haematopoietic cells with Purkinje neurons in response to chronic inflammation","volume":"10","author":"Johansson","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib30","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3389\/fonc.2015.00155","article-title":"Implications of the hybrid epithelial\/mesenchymal phenotype in metastasis","volume":"5","author":"Jolly","year":"2015","journal-title":"Front. Oncol."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib31","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/ni0903-815","article-title":"What is trogocytosis and what is its purpose?","volume":"4","author":"Joly","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15252\/emmm.201303698","article-title":"Biology, detection, and clinical implications of circulating tumor cells","volume":"7","author":"Joosse","year":"2015","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib33","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature06188","article-title":"Mesenchymal stem cells within tumour stroma promote breast cancer metastasis","volume":"449","author":"Karnoub","year":"2007","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib34","doi-asserted-by":"crossref","first-page":"4862","DOI":"10.3390\/cancers13194862","article-title":"Clinical significance of circulating tumor cell induced epithelial-mesenchymal transition in patients with metastatic colorectal cancer by single-cell rna-sequencing","volume":"13","author":"Kozuka","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib35","first-page":"1","article-title":"Molecular analysis of circulating tumour cells\u2014biology and biomarkers","author":"Krebs","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib36","doi-asserted-by":"crossref","unstructured":"Kvoka\u010dkov\u00e1, B., Rem\u0161\u00edk, J., Jolly, M.K., Sou\u010dek, K., 2021. Phenotypic Heterogeneity of Triple-Negative Breast Cancer Mediated by Epithelial-Mesenchymal Plasticity.","DOI":"10.3390\/cancers13092188"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0304-419X(85)90008-3","article-title":"Somatic cell hybridization in vivo and in vitro in relation to the metastatic phenotype","volume":"823","author":"Lagarde","year":"1985","journal-title":"Biochimica et. Biophysica Acta (BBA) \u2013 Rev. Cancer"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib38","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/ijc.2910340518","article-title":"Suggestive evidence that the highly metastatic variant ESB of the T-cell lymphoma eb is derived from spontaneous fusion with a host macrophage","volume":"34","author":"Larizza","year":"1984","journal-title":"Int. J. Cancer"},{"issue":"9","key":"10.1016\/bs.ircmb.2023.07.004_bib39","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1038\/bjc.2011.405","article-title":"Detection of circulating tumour cells with a hybrid (epithelial\/mesenchymal) phenotype in patients with metastatic non-small cell lung cancer","volume":"105","author":"Lecharpentier","year":"2011","journal-title":"Br. J. Cancer"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib40","doi-asserted-by":"crossref","first-page":"13259","DOI":"10.3748\/wjg.v21.i47.13259","article-title":"Evaluation of epithelial-mesenchymal transitioned circulating tumor cells in patients with resectable gastric cancer: relevance to therapy response","volume":"21","author":"Li","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib41","doi-asserted-by":"crossref","first-page":"R23","DOI":"10.1186\/bcr3622","article-title":"Heterogeneous atypical cell populations are present in blood of metastatic breast cancer patients","volume":"16","author":"Lustberg","year":"2014","journal-title":"Breast Cancer Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib42","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.cell.2008.03.027","article-title":"The epithelial-mesenchymal transition generates cells with properties of stem cells","volume":"133","author":"Mani","year":"2008","journal-title":"Cell"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib43","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.3390\/cells10051255","article-title":"The role of trogocytosis in the modulation of immune cell functions","volume":"10","author":"Miyake","year":"2021","journal-title":"Cells"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib44","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1073\/pnas.1615973114","article-title":"Trogocytosis of peptide-MHC class II complexes from dendritic cells confers antigen-presenting ability on basophils","volume":"114","author":"Miyake","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib45","first-page":"5","article-title":"Transcriptomic profiling of single circulating tumor cells provides insight into human metastatic gastric cancer","author":"Negishi","year":"2022","journal-title":"Commun. Biol."},{"issue":"5 10","key":"10.1016\/bs.ircmb.2023.07.004_bib46","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/ncb1721","article-title":"Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion","volume":"10","author":"Nygren","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib47","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1158\/1535-7163.MCT-18-0584","article-title":"Circulating tumor cells with stemness and epithelial-to-mesenchymal transition features are chemoresistant and predictive of poor outcome in metastatic breast cancer","volume":"18","author":"Papadaki","year":"2019","journal-title":"Mol. Cancer Therapeutics"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers13194885","article-title":"Heterogeneity of circulating tumor cell neoplastic subpopulations outlined by single-cell transcriptomics","volume":"13","author":"Pauken","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib49","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s004410051276","article-title":"Determination and development of the larval muscle pattern in Drosophila melanogaster","volume":"296","author":"Paululat","year":"1999","journal-title":"Cell Tissue Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib50","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/00008390-200012000-00001","article-title":"Tumour cell hybridization and metastasis revisited","volume":"10","author":"Pawelek","year":"2000","journal-title":"Melanoma Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib51","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1158\/2159-8290.CD-11-0215","article-title":"A novel platform for detection of CK+ and CK- CTCs","volume":"1","author":"Pecot","year":"2011","journal-title":"Cancer Discov."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib52","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1158\/0008-5472.CAN-10-3223","article-title":"Fusion between intestinal epithelial cells and macrophages in a cancer context results in nuclear reprogramming","volume":"71","author":"Powell","year":"2011","journal-title":"Cancer Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib53","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1073\/pnas.95.8.4589","article-title":"Detection and characterization of carcinoma cells in the blood","volume":"95","author":"Racila","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib54","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.semcancer.2019.10.008","article-title":"The curious phenomenon of dual-positive circulating cells: longtime overlooked tumor cells","volume":"60","author":"Reduzzi","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib55","first-page":"745","article-title":"Technique and results of isolation of cancer cells from the circulating blood","volume":"13","author":"Roberts","year":"1958","journal-title":"Obstetrical Gynecol. Surv."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib56","first-page":"9","article-title":"Circulating tumor cells as a tool to untangle the breast cancer heterogeneity issue","author":"Rossi","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib57","first-page":"555","article-title":"Atypical cells in the blood of cancer patients; differentiation from tumor cells","volume":"22","author":"Sandberg","year":"1959","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib58","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1158\/1078-0432.CCR-14-0894","article-title":"Epithelial-mesenchymal transitioned circulating tumor cells capture for detecting tumor progression","volume":"21","author":"Satelli","year":"2015","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib59","first-page":"2816","article-title":"Dendritic cells fused with endothelial progenitor cells play immunosuppressive effects on angiogenesis in acute myeloid leukemia mice","volume":"11","author":"Shen","year":"2019","journal-title":"Am. J. Transl. Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib60","first-page":"118","article-title":"Colon cancer cells acquire immune regulatory molecules from tumor-infiltrating lymphocytes by trogocytosis","author":"Shin","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib61","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.1200\/JCO.2014.56.2561","article-title":"Circulating tumor cells and response to chemotherapy in metastatic breast cancer: SWOG S0500","volume":"32","author":"Smerage","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib62","first-page":"20","article-title":"PMN-MDSCs enhance CTC metastatic properties through reciprocal interactions via ROS\/Notch\/Nodal signaling","author":"Sprouse","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib63","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.4049\/jimmunol.179.7.4424","article-title":"Intercellular transfer of carcinoembryonic antigen from tumor cells to NK cells","volume":"179","author":"Stern-Ginossar","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib64","doi-asserted-by":"crossref","first-page":"25ra23","DOI":"10.1126\/scitranslmed.3000403","article-title":"Isolation and characterization of circulating tumor cells from patients with localized and metastatic prostate cancer","volume":"2","author":"Stott","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib65","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ebiom.2019.07.044","article-title":"CTC phenotyping for a preoperative assessment of tumor metastasis and overall survival of pancreatic ductal adenocarcinoma patients","volume":"46","author":"Sun","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib66","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41586-019-0915-y","article-title":"Neutrophils escort circulating tumour cells to enable cell cycle progression","volume":"566","author":"Szczerba","year":"2019","journal-title":"Nature"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib67","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1084\/jem.20051123","article-title":"Macrophage fusion","volume":"202","author":"Vignery","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib68","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.ebiom.2019.04.049","article-title":"Stemness underpinning all steps of human colorectal cancer defines the core of effective therapeutic strategies","volume":"44","author":"Visioli","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib69","first-page":"2017","article-title":"Associations between the epithelial-mesenchymal transition phenotypes of circulating tumor cells and the clinicopathological features of patients with colorectal cancer","author":"Wu","year":"2017","journal-title":"Dis. Markers"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib70","first-page":"341","article-title":"Guidelines and definitions for research on epithelial\u2013mesenchymal transition","volume":"21","author":"Yang","year":"2020"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13058-020-01296-5","article-title":"Triple-negative breast cancer molecular subtyping and treatment progress","volume":"22","author":"Yin","year":"2020","journal-title":"Breast Cancer Res."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib72","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1126\/science.1228522","article-title":"Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition","volume":"339","author":"Yu","year":"2013","journal-title":"Science (N. York, N. Y.)"},{"key":"10.1016\/bs.ircmb.2023.07.004_bib73","doi-asserted-by":"crossref","first-page":"180ra48","DOI":"10.1126\/scitranslmed.3005109","article-title":"The identification and characterization of breast cancer CTCs competent for brain metastasis","volume":"5","author":"Zhang","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/bs.ircmb.2023.07.004_bib74","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1007\/s00432-021-03681-9","article-title":"Epithelial circulating tumor cells with a heterogeneous phenotype are associated with metastasis in NSCLC-CTCs\u00b7E\/M-CTCs\u00b7EMT\u00b7Metastasis","volume":"148","author":"Zhang","year":"2022","journal-title":"J. Cancer Res. Clin. Oncol."}],"container-title":["International Review of Cell and Molecular Biology","Circulating Tumor Cells, From Biotech Innovation to Clinical Utility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1937644823001181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1937644823001181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T12:06:18Z","timestamp":1753358778000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1937644823001181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9780443161346"],"references-count":74,"URL":"https:\/\/doi.org\/10.1016\/bs.ircmb.2023.07.004","relation":{},"ISSN":["1937-6448"],"issn-type":[{"value":"1937-6448","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}