{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T13:57:28Z","timestamp":1725976648858},"reference-count":107,"publisher":"Elsevier","isbn-type":[{"value":"9780128040133","type":"print"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1016\/bs.irn.2016.02.010","type":"book-chapter","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T22:32:51Z","timestamp":1458685971000},"page":"357-390","source":"Crossref","is-referenced-by-count":5,"title":["Gene Targeting Studies of Hyperexcitability and Affective States of Alcohol Withdrawal in Rodents"],"prefix":"10.1016","author":[{"given":"G.D.","family":"Greenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"Crabbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0005","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1465-3362.2008.00023.x","article-title":"Hormones and drinking behaviour: New findings on ghrelin, insulin, leptin and volume-regulating hormones. An ESBRA Symposium report","volume":"28","author":"Addolorato","year":"2009","journal-title":"Drug and Alcohol Review"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0010","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF02244208","article-title":"CRF antagonist reverses the \u201canxiogenic\u201d response to ethanol withdrawal in the rat","volume":"103","author":"Baldwin","year":"1991","journal-title":"Psychopharmacology"},{"key":"10.1016\/bs.irn.2016.02.010_bb9000","series-title":"Animal models for medications screening to treat addiction","article-title":"An animal model of alcohol dependence to screen medications for treating alcoholism","author":"Becker","year":"2016"},{"key":"10.1016\/bs.irn.2016.02.010_bb0015","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1016\/j.psyneuen.2009.05.021","article-title":"The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders","volume":"34","author":"Binder","year":"2009","journal-title":"Psychoneuroendocrinology"},{"issue":"06","key":"10.1016\/bs.irn.2016.02.010_bb0020","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1017\/S1461145708008584","article-title":"Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: Relationship to acamprosate actions","volume":"11","author":"Blednov","year":"2008","journal-title":"The International Journal of Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/bs.irn.2016.02.010_bb0025","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.neuropharm.2009.01.007","article-title":"Deletion of vanilloid receptor (TRPV1) in mice alters behavioral effects of ethanol","volume":"56","author":"Blednov","year":"2009","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/bs.irn.2016.02.010_bb0030","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1124\/jpet.103.049478","article-title":"GABAA receptor \u03b11 and \u03b22 subunit null mutant mice: Behavioral responses to ethanol","volume":"305","author":"Blednov","year":"2003","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.alcohol.2006.12.002","article-title":"Reduced alcohol consumption in mice lacking preprodynorphin","volume":"40","author":"Blednov","year":"2006","journal-title":"Alcohol"},{"issue":"7","key":"10.1016\/bs.irn.2016.02.010_bb0040","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1038\/sj.npp.1301274","article-title":"Role of endocannabinoids in alcohol consumption and intoxication: Studies of mice lacking fatty acid amide hydrolase","volume":"32","author":"Blednov","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0045","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1369-1600.2009.00186.x","article-title":"Preclinical study: Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol","volume":"15","author":"Blednov","year":"2010","journal-title":"Addiction Biology"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0050","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1124\/jpet.111.185124","article-title":"Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor \u03b11 subunit","volume":"340","author":"Blednov","year":"2012","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/bs.irn.2016.02.010_bb0055","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.neuropharm.2015.03.015","article-title":"Role of interleukin-1 receptor signaling in the behavioral effects of ethanol and benzodiazepines","volume":"95","author":"Blednov","year":"2015","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0060","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1124\/jpet.114.221895","article-title":"Glycine receptors containing \u03b12 or \u03b13 subunits regulate specific ethanol-mediated behaviors","volume":"353","author":"Blednov","year":"2015","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"4","key":"10.1016\/bs.irn.2016.02.010_bb0070","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/jlb.67.4.508","article-title":"The interleukin-1 receptor\/Toll-like receptor superfamily: Signal generators for pro-inflammatory interleukins and microbial products","volume":"67","author":"Bowie","year":"2000","journal-title":"Journal of Leukocyte Biology"},{"issue":"6","key":"10.1016\/bs.irn.2016.02.010_bb0075","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.alcohol.2009.05.003","article-title":"Differential activation of limbic circuitry associated with chronic ethanol withdrawal in DBA\/2J and C57BL\/6J mice","volume":"43","author":"Chen","year":"2009","journal-title":"Alcohol"},{"issue":"4","key":"10.1016\/bs.irn.2016.02.010_bb0080","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/j.pbb.2007.03.009","article-title":"Dependence-induced increases in ethanol self-administration in mice are blocked by the CRF1receptor antagonist antalarmin and by CRF1receptor knockout","volume":"86","author":"Chu","year":"2007","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"8","key":"10.1016\/bs.irn.2016.02.010_bb0085","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1001\/archpsyc.1981.01780330019001","article-title":"Inheritance of alcohol abuse: Cross-fostering analysis of adopted men","volume":"38","author":"Cloninger","year":"1981","journal-title":"Archives of General Psychiatry"},{"issue":"5","key":"10.1016\/bs.irn.2016.02.010_bb0090","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1111\/adb.12040","article-title":"\u03bc-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche","volume":"19","author":"Contet","year":"2013","journal-title":"Addiction Biology"},{"issue":"9","key":"10.1016\/bs.irn.2016.02.010_bb0095","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1111\/j.1530-0277.2012.01776.x","article-title":"Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures","volume":"36","author":"Cozzoli","year":"2012","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0100","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/npp.2013.214","article-title":"Binge alcohol drinking by mice requires intact Group 1 metabotropic glutamate receptor signaling within the central nucleus of the amygdale","volume":"39","author":"Cozzoli","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/bs.irn.2016.02.010_bb0105","series-title":"Determinants of substance abuse","first-page":"13","article-title":"The role of genetics in substance abuse","author":"Crabbe","year":"1985"},{"issue":"4","key":"10.1016\/bs.irn.2016.02.010_bb9010","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s00213-003-1608-6","article-title":"Review: Pharmacogenetic studies of alcohol self-administration and withdrawal","volume":"174","author":"Crabbe","year":"2004","journal-title":"Psychopharmacology"},{"issue":"3\u20134","key":"10.1016\/bs.irn.2016.02.010_bb0110","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1369-1600.2006.00038.x","article-title":"Review: Alcohol-related genes: Contributions from studies with genetically engineered mice","volume":"11","author":"Crabbe","year":"2006","journal-title":"Addiction Biology"},{"key":"10.1016\/bs.irn.2016.02.010_bb0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2478\/addge-2012-0002","article-title":"Ethanol withdrawal-associated drinking and drinking in the dark: Common and discrete genetic contributions","volume":"1","author":"Crabbe","year":"2012","journal-title":"Addiction Genetics"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0120","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/gbb.12105","article-title":"Progress in a replicated selection for elevated blood ethanol concentrations in HDID mice","volume":"13","author":"Crabbe","year":"2014","journal-title":"Genes, Brain and Behavior"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0125","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/adb.12110","article-title":"Tolerance to ethanol intoxication after chronic ethanol: Role of GluN2A and PSD-95","volume":"20","author":"Daut","year":"2014","journal-title":"Addiction Biology"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0130","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/YCO.0b013e3282f32408","article-title":"Major depression and comorbid substance use disorders","volume":"21","author":"Davis","year":"2008","journal-title":"Current Opinion in Psychiatry"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0135","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ntt.2011.09.001","article-title":"Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain","volume":"34","author":"Du","year":"2012","journal-title":"Neurotoxicology and Teratology"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0140","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0165-0173(90)90012-D","article-title":"Physiological and behavioral responses to corticotropin-releasing factor administration: Is CRF a mediator of anxiety or stress responses?","volume":"15","author":"Dunn","year":"1990","journal-title":"Brain Research Reviews"},{"issue":"5","key":"10.1016\/bs.irn.2016.02.010_bb0145","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0301-0082(98)00027-6","article-title":"Ethanol and neurotransmitter interactions\u2014From molecular to integrative effects","volume":"55","author":"Faingold","year":"1998","journal-title":"Progress in Neurobiology"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0150","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1111\/j.1369-1600.2011.00378.x","article-title":"Increased ethanol intake in prodynorphin knockout mice is associated to changes in opioid receptor function and dopamine transmission","volume":"17","author":"Femen\u00eda","year":"2012","journal-title":"Addiction Biology"},{"issue":"7","key":"10.1016\/bs.irn.2016.02.010_bb0155","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.4049\/jimmunol.0803590","article-title":"Critical role of TLR4 response in the activation of microglia induced by ethanol","volume":"183","author":"Fernandez-Lizarbe","year":"2009","journal-title":"The Journal of Immunology"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0160","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.yhbeh.2009.07.002","article-title":"Manipulation of GABAergic steroids: Sex differences in the effects on alcohol drinking-and withdrawal-related behaviors","volume":"57","author":"Finn","year":"2010","journal-title":"Hormones and Behavior"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0165","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0091-3057(93)90082-5","article-title":"Angiotensin and captopril increase alcohol intake","volume":"45","author":"Fitts","year":"1993","journal-title":"Pharmacology Biochemistry and Behavior"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0170","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/01.ALC.0000150014.79657.64","article-title":"Effects of topiramate on ethanol and saccharin consumption and preferences in C57BL\/6J mice","volume":"29","author":"Gabriel","year":"2005","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0175","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bcp.2007.06.039","article-title":"Glutamatergic substrates of drug addiction and alcoholism","volume":"75","author":"Gass","year":"2008","journal-title":"Biochemical Pharmacology"},{"issue":"3","key":"10.1016\/bs.irn.2016.02.010_bb0180","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0741-8329(99)00045-2","article-title":"Effects of NMDA antagonists on ethanol-withdrawal induced \u201canxiety\u201d in the elevated plus maze","volume":"19","author":"Gatch","year":"1999","journal-title":"Alcohol"},{"issue":"4","key":"10.1016\/bs.irn.2016.02.010_bb0185","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.neuropharm.2005.04.006","article-title":"Lack of stimulant and anxiolytic-like effects of ethanol and accelerated development of ethanol dependence in mu-opioid receptor knockout mice","volume":"49","author":"Ghozland","year":"2005","journal-title":"Neuropharmacology"},{"issue":"11","key":"10.1016\/bs.irn.2016.02.010_bb0190","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1001\/archpsyc.55.11.964","article-title":"General and specific inheritance of substance abuse and alcoholism","volume":"55","author":"Goldman","year":"1998","journal-title":"Archives of General Psychiatry"},{"issue":"6","key":"10.1016\/bs.irn.2016.02.010_bb0195","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1111\/j.1530-0277.2006.00125.x","article-title":"Progress in using mouse inbred strains, consomics, and mutants to identify genes related to stress, anxiety, and alcohol phenotypes","volume":"30","author":"Goldowitz","year":"2006","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"5421","key":"10.1016\/bs.irn.2016.02.010_bb0200","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/245154a0","article-title":"Inherited differences in intensity of alcohol withdrawal reactions in mice","volume":"245","author":"Goldstein","year":"1973","journal-title":"Nature"},{"issue":"4","key":"10.1016\/bs.irn.2016.02.010_bb0205","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/npp.2012.225","article-title":"Glucocorticoid receptor and FKBP5 expression is altered following exposure to chronic stress: Modulation by antidepressant treatment","volume":"38","author":"Guidotti","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"11","key":"10.1016\/bs.irn.2016.02.010_bb0210","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1111\/j.1530-0277.2008.00787.x","article-title":"Acute effects of acamprosate and MPEP on ethanol drinking-in-the-dark in male C57BL\/6J mice","volume":"32","author":"Gupta","year":"2008","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"36","key":"10.1016\/bs.irn.2016.02.010_bb0215","doi-asserted-by":"crossref","first-page":"14369","DOI":"10.1523\/JNEUROSCI.1954-13.2013","article-title":"Protein tyrosine phosphatase \u03b1 in the dorsomedial striatum promotes excessive ethanol-drinking behaviors","volume":"33","author":"Hamida","year":"2013","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0220","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.neuropharm.2011.07.041","article-title":"The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress","volume":"62","author":"Hartmann","year":"2012","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0225","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1369-1600.2009.00194.x","article-title":"Review: Acute withdrawal, protracted abstinence and negative affect in alcoholism: Are they linked?","volume":"15","author":"Heilig","year":"2010","journal-title":"Addiction Biology"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0230","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1124\/jpet.103.052092","article-title":"Corticotropin-releasing factor in brain: A role in activation, arousal, and affect regulation","volume":"311","author":"Heinrichs","year":"2004","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"05","key":"10.1016\/bs.irn.2016.02.010_bb0235","doi-asserted-by":"crossref","first-page":"953","DOI":"10.15288\/jsa.1977.38.953","article-title":"Alcohol withdrawal symptoms and drinking behavior","volume":"38","author":"Hershon","year":"1977","journal-title":"Journal of Studies on Alcohol and Drugs"},{"issue":"8","key":"10.1016\/bs.irn.2016.02.010_bb0240","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/npp.2014.55","article-title":"FKBP5 moderates alcohol withdrawal severity: Human genetic association and functional validation in knockout mice","volume":"39","author":"Huang","year":"2014","journal-title":"Neuropsychopharmacology"},{"issue":"8","key":"10.1016\/bs.irn.2016.02.010_bb0245","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrn2515","article-title":"The glutamate homeostasis hypothesis of addiction","volume":"10","author":"Kalivas","year":"2009","journal-title":"Nature Reviews Neuroscience"},{"issue":"6","key":"10.1016\/bs.irn.2016.02.010_bb0250","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0741-8329(92)90092-O","article-title":"Specific and nonspecific effects of ethanol vapor on plasma corticosterone in mice","volume":"9","author":"Keith","year":"1992","journal-title":"Alcohol"},{"issue":"6","key":"10.1016\/bs.irn.2016.02.010_bb0255","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archpsyc.62.6.617","article-title":"Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Archives of General Psychiatry"},{"issue":"4","key":"10.1016\/bs.irn.2016.02.010_bb0260","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0006-3223(02)01486-5","article-title":"Involvement of NMDA receptors in alcohol-mediated behavior: Mice with reduced affinity of the NMDA R1 glycine binding site display an attenuated sensitivity to ethanol","volume":"53","author":"Kiefer","year":"2003","journal-title":"Biological Psychiatry"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0265","doi-asserted-by":"crossref","first-page":"e16331","DOI":"10.1371\/journal.pone.0016331","article-title":"Functional role of the polymorphic 647T\/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures","volume":"6","author":"Kim","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0270","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.alcohol.2003.08.007","article-title":"SB242084, flumazenil, and CRA1000 block ethanol withdrawal\u2013induced anxiety in rats","volume":"32","author":"Knapp","year":"2004","journal-title":"Alcohol"},{"key":"10.1016\/bs.irn.2016.02.010_bb0275","series-title":"Behavioral Neurobiology of Alcohol Addiction","first-page":"3","article-title":"Theoretical frameworks and mechanistic aspects of alcohol addiction: Alcohol addiction as a reward deficit disorder","author":"Koob","year":"2013"},{"issue":"5335","key":"10.1016\/bs.irn.2016.02.010_bb0280","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1126\/science.278.5335.52","article-title":"Drug abuse: Hedonic homeostatic dysregulation","volume":"278","author":"Koob","year":"1997","journal-title":"Science"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0285","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0893-133X(00)00195-0","article-title":"Drug addiction, dysregulation of reward, and allostasis","volume":"24","author":"Koob","year":"2001","journal-title":"Neuropsychopharmacology"},{"issue":"37","key":"10.1016\/bs.irn.2016.02.010_bb0290","doi-asserted-by":"crossref","first-page":"11662","DOI":"10.1523\/JNEUROSCI.1413-09.2009","article-title":"Mapping a barbiturate withdrawal locus to a 0.44Mb interval and analysis of a novel null mutant identify a role for Kcnj9 (GIRK3) in withdrawal from pentobarbital, zolpidem, and ethanol","volume":"29","author":"Kozell","year":"2009","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/bs.irn.2016.02.010_bb0295","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.3389\/fnint.2013.00105","article-title":"BK channel \u03b21 and \u03b24 auxiliary subunits exert opposite influences on escalated ethanol drinking in dependent mice","volume":"7","author":"Kreifeldt","year":"2013","journal-title":"Frontiers in Integrative Neuroscience"},{"issue":"4","key":"10.1016\/bs.irn.2016.02.010_bb0300","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1530-0277.2007.00344.x","article-title":"Antiglutamatergic strategies for ethanol detoxification: Comparison with placebo and diazepam","volume":"31","author":"Krupitsky","year":"2007","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"8","key":"10.1016\/bs.irn.2016.02.010_bb0305","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/gbb.12171","article-title":"Mpdz expression in the caudolateral substantia nigra pars reticulata is crucially involved in alcohol withdrawal","volume":"13","author":"Kruse","year":"2014","journal-title":"Genes, Brain and Behavior"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0310","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0272-7358(99)00027-6","article-title":"The relationship between anxiety disorders and alcohol use disorders: A review of major perspectives and findings","volume":"20","author":"Kushner","year":"2000","journal-title":"Clinical Psychology Review"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0315","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/alcalc\/agh115","article-title":"Ethanol induces higher BEC in CB1 cannabinoid receptor knockout mice while decreasing ethanol preference","volume":"40","author":"Lallemand","year":"2005","journal-title":"Alcohol and Alcoholism"},{"key":"10.1016\/bs.irn.2016.02.010_bb0320","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbr.2015.05.055","article-title":"Binge alcohol drinking elicits persistent negative affect in mice","volume":"291","author":"Lee","year":"2015","journal-title":"Behavioural Brain Research"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0325","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1124\/jpet.114.222463","article-title":"Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression","volume":"353","author":"Lindemann","year":"2015","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"issue":"3","key":"10.1016\/bs.irn.2016.02.010_bb0330","first-page":"299","article-title":"Pharmacological modulation of HPA axis in depression\u2014New avenues for potential therapeutic benefits","volume":"25","author":"Maric","year":"2013","journal-title":"Psychiatria Danubina"},{"key":"10.1016\/bs.irn.2016.02.010_bb9015","series-title":"Animal models for medications screening to treat addiction","article-title":"Genes and alcohol consumption: Studies with mutant mice","author":"Mayfield","year":"2016"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0335","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/bjp.2008.88","article-title":"Genetic factors influencing alcohol dependence","volume":"154","author":"Mayfield","year":"2008","journal-title":"British Journal of Pharmacology"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0340","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.alcohol.2015.01.003","article-title":"Chronic intermittent ethanol inhalation increases ethanol self-administration in both C57BL\/6J and DBA\/2J mice","volume":"49","author":"McCool","year":"2015","journal-title":"Alcohol"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/adb.12187","article-title":"Postdependent state in rats as a model for medication development in alcoholism","volume":"20","author":"Meinhardt","year":"2015","journal-title":"Addiction Biology"},{"issue":"7","key":"10.1016\/bs.irn.2016.02.010_bb0350","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1523\/JNEUROSCI.4062-12.2013","article-title":"Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence","volume":"33","author":"Meinhardt","year":"2013","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"10.1016\/bs.irn.2016.02.010_bb0355","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1037\/0735-7044.119.4.911","article-title":"Alcohol withdrawal severity in inbred mouse (Mus musculus) strains","volume":"119","author":"Metten","year":"2005","journal-title":"Behavioral Neuroscience"},{"issue":"12","key":"10.1016\/bs.irn.2016.02.010_bb0360","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s003359900911","article-title":"High genetic susceptibility to ethanol withdrawal predicts low ethanol consumption","volume":"9","author":"Metten","year":"1998","journal-title":"Mammalian Genome"},{"issue":"9","key":"10.1016\/bs.irn.2016.02.010_bb0365","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1111\/j.1530-0277.2010.01240.x","article-title":"Withdrawal severity after chronic intermittent ethanol in inbred mouse strains","volume":"34","author":"Metten","year":"2010","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0370","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/adb.12087","article-title":"Novel MPDZ\/MUPP1 transgenic and knockdown models confirm Mpdz's role in ethanol withdrawal and support its role in voluntary ethanol consumption","volume":"20","author":"Milner","year":"2013","journal-title":"Addiction Biology"},{"issue":"4","key":"10.1016\/bs.irn.2016.02.010_bb0375","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/npp.2011.297","article-title":"Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking","volume":"37","author":"Molander","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/bs.irn.2016.02.010_bb0380","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0741-8329(85)90133-8","article-title":"Clinical conditions in alcoholics during long-term abstinence: A descriptive, longitudinal treatment study","volume":"2","author":"Mossberg","year":"1985","journal-title":"Alcohol"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0385","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.brainresrev.2008.09.001","article-title":"Toll-like receptors in neurodegeneration","volume":"59","author":"Okun","year":"2009","journal-title":"Brain Research Reviews"},{"key":"10.1016\/bs.irn.2016.02.010_bb0390","series-title":"Neurobiology of alcohol dependence","article-title":"Anxiety and alcohol use disorders","author":"Pandey","year":"2014"},{"key":"10.1016\/bs.irn.2016.02.010_bb0395","doi-asserted-by":"crossref","first-page":"S80","DOI":"10.1016\/j.bbi.2011.02.012","article-title":"Impact of TLR4 on behavioral and cognitive dysfunctions associated with alcohol-induced neuroinflammatory damage","volume":"25","author":"Pascual","year":"2011","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/bs.irn.2016.02.010_bb0400","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.neuropharm.2014.10.014","article-title":"Cytokines and chemokines as biomarkers of ethanol-induced neuroinflammation and anxiety-related behavior: Role of TLR4 and TLR2","volume":"89","author":"Pascual","year":"2015","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0405","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s002130051128","article-title":"Complications associated with genetic background effects in research using knockout mice","volume":"147","author":"Phillips","year":"1999","journal-title":"Psychopharmacology"},{"issue":"8","key":"10.1016\/bs.irn.2016.02.010_bb0410","doi-asserted-by":"crossref","first-page":"5439","DOI":"10.1523\/JNEUROSCI.15-08-05439.1995","article-title":"Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis","volume":"15","author":"Pich","year":"1995","journal-title":"The Journal of Neuroscience"},{"issue":"6","key":"10.1016\/bs.irn.2016.02.010_bb0415","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1523\/JNEUROSCI.23-06-02453.2003","article-title":"A critical role for the cannabinoid CB1 receptors in alcohol dependence and stress-stimulated ethanol drinking","volume":"23","author":"Racz","year":"2003","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/bs.irn.2016.02.010_bb0420","series-title":"Neurobiology of alcohol dependence","article-title":"The effects of stress on measures of alcohol drinking in rodents","author":"Radke","year":"2014"},{"key":"10.1016\/bs.irn.2016.02.010_bb0425","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2010.03.063","article-title":"Genome-wide gene expression analysis identifies K-ras as a regulator of alcohol intake","volume":"1339","author":"Repunte-Canonigo","year":"2010","journal-title":"Brain Research"},{"key":"10.1016\/bs.irn.2016.02.010_bb0430","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.brainres.2010.03.060","article-title":"A potential role for adiponectin receptor 2 (AdipoR2) in the regulation of alcohol intake","volume":"1339","author":"Repunte-Canonigo","year":"2010","journal-title":"Brain Research"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0435","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1096\/fj.01-0593com","article-title":"Long-lasting increase in voluntary ethanol consumption and transcriptional regulation in the rat brain after intermittent exposure to alcohol","volume":"16","author":"Rimondini","year":"2002","journal-title":"The FASEB Journal"},{"issue":"5","key":"10.1016\/bs.irn.2016.02.010_bb0440","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/sj.npp.1300840","article-title":"Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdala","volume":"31","author":"Roberto","year":"2005","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/bs.irn.2016.02.010_bb0445","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.neulet.2007.02.024","article-title":"Etomidate and propofol-hyposensitive GABAA receptor \u03b23 (N265M) mice show little changes in acute alcohol sensitivity but enhanced tolerance and withdrawal","volume":"416","author":"Sanchis-Segura","year":"2007","journal-title":"Neuroscience Letters"},{"issue":"3","key":"10.1016\/bs.irn.2016.02.010_bb0450","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.alcohol.2015.01.009","article-title":"N-acetylcysteine prevents behavioral and biochemical changes induced by alcohol cessation in rats","volume":"49","author":"Schneider","year":"2015","journal-title":"Alcohol"},{"issue":"10","key":"10.1016\/bs.irn.2016.02.010_bb0455","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s00109-007-0255-5","article-title":"Plasticity and impact of the central renin\u2013angiotensin system during development of ethanol dependence","volume":"85","author":"Sommer","year":"2007","journal-title":"Journal of Molecular Medicine"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0460","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1152\/physrev.00013.2008","article-title":"Alcoholism: A systems approach from molecular physiology to addictive behavior","volume":"89","author":"Spanagel","year":"2009","journal-title":"Physiological Reviews"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0465","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0169-328X(02)00400-X","article-title":"Resistance to alcohol withdrawal-induced behaviour in Fyn transgenic mice and its reversal by ifenprodil","volume":"105","author":"Stork","year":"2002","journal-title":"Molecular Brain Research"},{"issue":"6","key":"10.1016\/bs.irn.2016.02.010_bb0470","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/j.1360-0443.2010.02902.x","article-title":"Mental disorders as risk factors for substance use, abuse and dependence: Results from the 10-year follow-up of the National Comorbidity Survey","volume":"105","author":"Swendsen","year":"2010","journal-title":"Addiction"},{"key":"10.1016\/bs.irn.2016.02.010_bb0475","series-title":"Neurobiology of alcohol dependence","article-title":"Glutamate signaling in alcohol abuse and dependence","author":"Szumlinksi","year":"2014"},{"issue":"3","key":"10.1016\/bs.irn.2016.02.010_bb0480","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1007\/s10519-014-9691-5","article-title":"Sex differences in ethanol's anxiolytic effect and chronic ethanol withdrawal severity in mice with a null mutation of the 5\u03b1-reductase type 1 gene","volume":"45","author":"Tanchuck-Nipper","year":"2014","journal-title":"Behavior Genetics"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0485","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/520","article-title":"Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1","volume":"19","author":"Timpl","year":"1998","journal-title":"Nature Genetics"},{"issue":"6","key":"10.1016\/bs.irn.2016.02.010_bb0490","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1111\/j.1460-9568.2009.06684.x","article-title":"GABAA receptors mediate the opposing roles of dopamine and the tegmental pedunculopontine nucleus in the motivational effects of ethanol","volume":"29","author":"Ting-A-Kee","year":"2009","journal-title":"European Journal of Neuroscience"},{"issue":"8","key":"10.1016\/bs.irn.2016.02.010_bb0495","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/syn.20533","article-title":"Genetic and pharmacological manipulations of the CB1 receptor alter ethanol preference and dependence in ethanol preferring and nonpreferring mice","volume":"62","author":"Vinod","year":"2008","journal-title":"Synapse"},{"issue":"1","key":"10.1016\/bs.irn.2016.02.010_bb0500","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1471-4159.2007.04956.x","article-title":"Manipulation of fatty acid amide hydrolase functional activity alters sensitivity and dependence to ethanol","volume":"104","author":"Vinod","year":"2008","journal-title":"Journal of Neurochemistry"},{"issue":"4","key":"10.1016\/bs.irn.2016.02.010_bb0505","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.alcohol.2011.10.006","article-title":"Targeting dynorphin\/kappa opioid receptor systems to treat alcohol abuse and dependence","volume":"46","author":"Walker","year":"2012","journal-title":"Alcohol"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0510","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00213-010-1825-8","article-title":"The role of the dynorphin-\u03ba opioid system in the reinforcing effects of drugs of abuse","volume":"210","author":"Wee","year":"2010","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0515","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1530-0277.2008.00832.x","article-title":"Alcohol-induced tolerance and physical dependence in mice with ethanol insensitive \u03b11 GABAA receptors","volume":"33","author":"Werner","year":"2009","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"2","key":"10.1016\/bs.irn.2016.02.010_bb0520","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/(SICI)1096-8628(19960409)67:2<197::AID-AJMG10>3.0.CO;2-E","article-title":"Familial alcoholism in manic-depressive (bipolar) disease","volume":"67","author":"Winokur","year":"1996","journal-title":"American Journal of Medical Genetics"},{"issue":"42","key":"10.1016\/bs.irn.2016.02.010_bb0525","doi-asserted-by":"crossref","first-page":"16963","DOI":"10.1073\/pnas.1309839110","article-title":"Loss of metabotropic glutamate receptor 2 escalates alcohol consumption","volume":"110","author":"Zhou","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"}],"container-title":["International Review of Neurobiology","Animal Models for Medications Screening to Treat Addiction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774216300101?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774216300101?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T06:51:48Z","timestamp":1718434308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0074774216300101"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9780128040133"],"references-count":107,"URL":"https:\/\/doi.org\/10.1016\/bs.irn.2016.02.010","relation":{},"ISSN":["0074-7742"],"issn-type":[{"value":"0074-7742","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}