{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T18:54:13Z","timestamp":1775156053551,"version":"3.50.1"},"reference-count":144,"publisher":"Elsevier","isbn-type":[{"value":"9780128039151","type":"print"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1016\/bs.irn.2016.03.008","type":"book-chapter","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T09:47:24Z","timestamp":1461923244000},"page":"287-317","source":"Crossref","is-referenced-by-count":51,"title":["Wherefore Art Thou, O Treatment for Diabetic Neuropathy?"],"prefix":"10.1016","author":[{"given":"R.A.","family":"Malik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/bs.irn.2016.03.008_bb0005","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1046\/j.1464-5491.2002.00698.x","article-title":"The north-west diabetes foot care study: Incidence of, and risk factors for, new diabetic foot ulceration in a community-based patient cohort","volume":"19","author":"Abbott","year":"2002","journal-title":"Diabetic Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0010","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.2337\/dc11-1108","article-title":"Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetic population in the U.K","volume":"34","author":"Abbott","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0015","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0025-7753(02)72442-1","article-title":"Effects of kidney and pancreas transplantation on neurophysiological rates of polyneuropathy and autonomous cardiac function in diabetic patients with end-stage renal disease","volume":"118","author":"Agudo","year":"2002","journal-title":"Medicina Cl\u00ednica (Barcelona)"},{"key":"10.1016\/bs.irn.2016.03.008_bb0020","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/mt.2013.69","article-title":"Phase 1\/2 open-label dose-escalation study of plasmid DNA expressing two isoforms of hepatocyte growth factor in patients with painful diabetic peripheral neuropathy","volume":"21","author":"Ajroud-Driss","year":"2013","journal-title":"Molecular Therapy"},{"key":"10.1016\/bs.irn.2016.03.008_bb0030","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s10072-015-2207-0","article-title":"An inverse association between serum vitamin D levels with the presence and severity of impaired nerve conduction velocity and large fiber peripheral neuropathy in diabetic subjects","volume":"36","author":"Alamdari","year":"2015","journal-title":"Neurological Sciences"},{"key":"10.1016\/bs.irn.2016.03.008_bb0035","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1002\/ajh.24086","article-title":"Non-Hodgkin lymphoma subtype distribution, geodemographic patterns, and survival in the US: A longitudinal analysis of the National Cancer Data Base from 1998 to 2011","volume":"90","author":"Al-Hamadani","year":"2015","journal-title":"American Journal of Hematology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0040","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2337\/dc15-0995","article-title":"Reduced lower-limb muscle strength and volume in patients with type 2 diabetes in relation to neuropathy, intramuscular fat, and vitamin D levels","volume":"39","author":"Almurdhi","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0045","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nm0696-703","article-title":"The role of endogenous nerve growth factor in human diabetic neuropathy","volume":"2","author":"Anand","year":"1996","journal-title":"Nature Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0050","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/B978-0-444-53480-4.00007-2","article-title":"Motor neuropathy","volume":"126","author":"Andersen","year":"2014","journal-title":"Handbook of Clinical Neurology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0055","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0074-7742(02)50083-0","article-title":"Nerve growth factor for the treatment of diabetic neuropathy: What went wrong, what went right, and what does the future hold?","volume":"50","author":"Apfel","year":"2002","journal-title":"International Review of Neurobiology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0060","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1212\/WNL.51.3.695","article-title":"Recombinant human nerve growth factor in the treatment of diabetic polyneuropathy. NGF Study Group","volume":"51","author":"Apfel","year":"1998","journal-title":"Neurology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0065","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1742-481X.2007.00392.x","article-title":"Guest editorial: Are diabetes-related wounds and amputations worse than cancer?","volume":"4","author":"Armstrong","year":"2007","journal-title":"International Wound Journal"},{"key":"10.1016\/bs.irn.2016.03.008_bb0070","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.2337\/dc14-0279","article-title":"Corneal confocal microscopy detects neuropathy in subjects with impaired glucose tolerance","volume":"37","author":"Asghar","year":"2014","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0075","article-title":"The role of neuromediators and innervation in cutaneous wound healing","author":"Ashrafi","year":"2015","journal-title":"Acta Dermato-Venereologica"},{"key":"10.1016\/bs.irn.2016.03.008_bb0085","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.2337\/dc14-1698","article-title":"Corneal confocal microscopy shows an improvement in small-fiber neuropathy in subjects with type 1 diabetes on continuous subcutaneous insulin infusion compared with multiple daily injection","volume":"38","author":"Azmi","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0090","doi-asserted-by":"crossref","first-page":"375","DOI":"10.4093\/dmj.2013.37.5.375","article-title":"Ruboxistaurin for the treatment of diabetic peripheral neuropathy: A systematic review of randomized clinical trials","volume":"37","author":"Bansal","year":"2013","journal-title":"Diabetes & Metabolism Journal"},{"issue":"1","key":"10.1016\/bs.irn.2016.03.008_bb9000","doi-asserted-by":"crossref","first-page":"e000148","DOI":"10.1136\/bmjdrc-2015-000148","article-title":"Vitamin D for the treatment of painful diabetic neuropathy","volume":"4","author":"Basit","year":"2016","journal-title":"BMJ Open Diabetes Research and Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0100","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0828-282X(06)70925-4","article-title":"Trends in five-year survival of patients discharged after acute myocardial infarction","volume":"22","author":"Bata","year":"2006","journal-title":"The Canadian Journal of Cardiology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0105","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.neuroscience.2011.04.066","article-title":"Vitamin D(3) improves respiratory adjustment to fatigue and H-reflex responses in paraplegic adult rats","volume":"188","author":"Bianco","year":"2011","journal-title":"Neuroscience"},{"key":"10.1016\/bs.irn.2016.03.008_bb0110","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jns5.12072","article-title":"Phenotyping animal models of diabetic neuropathy: A consensus statement of the diabetic neuropathy study group of the EASD (Neurodiab)","volume":"19","author":"Biessels","year":"2014","journal-title":"Journal of the Peripheral Nervous System"},{"key":"10.1016\/bs.irn.2016.03.008_bb0115","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/dme.12324","article-title":"Corneal nerve fibre damage precedes diabetic retinopathy in patients with type 2 diabetes mellitus","volume":"31","author":"Bitirgen","year":"2014","journal-title":"Diabetic Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0120","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.2337\/dc07-2409","article-title":"Epidermal innervation in type 1 diabetic patients: A 2.5-year prospective study after simultaneous pancreas\/kidney transplantation","volume":"31","author":"Boucek","year":"2008","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0125","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/dmrr.2397","article-title":"Whither pathogenetic treatments for diabetic polyneuropathy?","volume":"29","author":"Boulton","year":"2013","journal-title":"Diabetes\/Metabolism Research and Reviews"},{"key":"10.1016\/bs.irn.2016.03.008_bb0130","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.2337\/diacare.27.6.1458","article-title":"Diabetic somatic neuropathies","volume":"27","author":"Boulton","year":"2004","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0135","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/S0140-6736(05)67698-2","article-title":"The global burden of diabetic foot disease","volume":"366","author":"Boulton","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/bs.irn.2016.03.008_bb0140","doi-asserted-by":"crossref","first-page":"d4169","DOI":"10.1136\/bmj.d4169","article-title":"Effect of intensive glucose lowering treatment on all cause mortality, cardiovascular death, and microvascular events in type 2 diabetes: Meta-analysis of randomised controlled trials","volume":"343","author":"Boussageon","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/bs.irn.2016.03.008_bb0145","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/pme.12677","article-title":"Exploring the role of tanezumab as a novel treatment for the relief of neuropathic pain","volume":"16","author":"Bramson","year":"2015","journal-title":"Pain Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0150","doi-asserted-by":"crossref","first-page":"658","DOI":"10.2119\/molmed.2014.00167","article-title":"ARA 290, a nonerythropoietic peptide engineered from erythropoietin, improves metabolic control and neuropathic symptoms in patients with type 2 diabetes","volume":"20","author":"Brines","year":"2014","journal-title":"Molecular Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0155","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.jdiacomp.2007.07.002","article-title":"Endothelial and neural regulation of skin microvascular blood flow in patients with diabetic peripheral neuropathy: Effect of treatment with the isoform-specific protein kinase C beta inhibitor, ruboxistaurin","volume":"22","author":"Brooks","year":"2008","journal-title":"Journal of Diabetes and its Complications"},{"key":"10.1016\/bs.irn.2016.03.008_bb0160","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jns.2014.07.028","article-title":"Nerve safety of tanezumab, a nerve growth factor inhibitor for pain treatment","volume":"345","author":"Brown","year":"2014","journal-title":"Journal of the Neurological Sciences"},{"key":"10.1016\/bs.irn.2016.03.008_bb0165","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S1474-4422(12)70065-0","article-title":"Diabetic neuropathy: Clinical manifestations and current treatments","volume":"11","author":"Callaghan","year":"2012","journal-title":"Lancet Neurology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0170","first-page":"CD007543","article-title":"Enhanced glucose control for preventing and treating diabetic neuropathy","volume":"6","author":"Callaghan","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1016\/bs.irn.2016.03.008_bb0175","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2337\/dc09-1471","article-title":"Effect of intensive compared with standard glycemia treatment strategies on mortality by baseline subgroup characteristics: The Action to Control Cardiovascular Risk in Diabetes (ACCORD) trial","volume":"33","author":"Calles-Escandon","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0180","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s13760-014-0304-0","article-title":"Decreased serum vitamin D levels are associated with diabetic peripheral neuropathy in a rural area of Turkey","volume":"115","author":"Celikbilek","year":"2015","journal-title":"Acta Neurologica Belgica"},{"key":"10.1016\/bs.irn.2016.03.008_bb0185","first-page":"CD004572","article-title":"Aldose reductase inhibitors for the treatment of diabetic polyneuropathy","author":"Chalk","year":"2007","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"10.1016\/bs.irn.2016.03.008_bb0195","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.2337\/dc14-2422","article-title":"Small nerve fiber quantification in the diagnosis of diabetic sensorimotor polyneuropathy: Comparing corneal confocal microscopy with intraepidermal nerve fiber density","volume":"38","author":"Chen","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0200","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.media.2011.05.016","article-title":"Automatic analysis of diabetic peripheral neuropathy using multi-scale quantitative morphology of nerve fibres in corneal confocal microscopy imaging","volume":"15","author":"Dabbah","year":"2011","journal-title":"Medical Image Analysis"},{"key":"10.1016\/bs.irn.2016.03.008_bb0205","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s00125-007-0919-2","article-title":"Lipid-lowering therapy and peripheral sensory neuropathy in type 2 diabetes: The Fremantle Diabetes Study","volume":"51","author":"Davis","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/bs.irn.2016.03.008_bb0210","doi-asserted-by":"crossref","DOI":"10.1097\/ICO.0000000000000760","article-title":"Risk factors associated with corneal nerve alteration in type 1 diabetes in the absence of neuropathy: A longitudinal In Vivo corneal confocal microscopy study","author":"Dehghani","year":"2016","journal-title":"Cornea"},{"key":"10.1016\/bs.irn.2016.03.008_bb0215","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.2337\/dc07-0206","article-title":"Evaluation of polyneuropathy markers in type 1 diabetic kidney transplant patients and effects of islet transplantation: Neurophysiological and skin biopsy longitudinal analysis","volume":"30","author":"Del Carro","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0220","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00125-010-1854-1","article-title":"Estimated glomerular filtration rate and albuminuria are independent predictors of cardiovascular events and death in type 2 diabetes mellitus: The Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study","volume":"54","author":"Drury","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/bs.irn.2016.03.008_bb0225","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1056\/NEJMoa0808431","article-title":"Glucose control and vascular complications in veterans with type 2 diabetes","volume":"360","author":"Duckworth","year":"2009","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0230","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/B978-0-444-53480-4.00024-2","article-title":"Methodology for conduct of epidemiologic surveys and randomized controlled trials of diabetic polyneuropathy","volume":"126","author":"Dyck","year":"2014","journal-title":"Handbook of Clinical Neurology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0235","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/mus.23765","article-title":"A trial of proficiency of nerve conduction: Greater standardization still needed","volume":"48","author":"Dyck","year":"2013","journal-title":"Muscle & Nerve"},{"key":"10.1016\/bs.irn.2016.03.008_bb0240","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/mus.23982","article-title":"Multicenter trial of the proficiency of smart quantitative sensation tests","volume":"49","author":"Dyck","year":"2014","journal-title":"Muscle & Nerve"},{"key":"10.1016\/bs.irn.2016.03.008_bb0245","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.2337\/dc06-2479","article-title":"Challenges in design of multicenter trials: End points assessed longitudinally for change and monotonicity","volume":"30","author":"Dyck","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0250","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/mus.21661","article-title":"Signs and symptoms versus nerve conduction studies to diagnose diabetic sensorimotor polyneuropathy: Cl vs. NPhys trial","volume":"42","author":"Dyck","year":"2010","journal-title":"Muscle & Nerve"},{"key":"10.1016\/bs.irn.2016.03.008_bb0255","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1056\/NEJM198809013190904","article-title":"Nerve glucose, fructose, sorbitol, myo-inositol, and fiber degeneration and regeneration in diabetic neuropathy","volume":"319","author":"Dyck","year":"1988","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0265","doi-asserted-by":"crossref","first-page":"536","DOI":"10.2337\/diabetes.52.2.536","article-title":"Amelioration of sensory nerve dysfunction by C-peptide in patients with type 1 diabetes","volume":"52","author":"Ekberg","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/bs.irn.2016.03.008_bb0270","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2337\/dc06-1274","article-title":"C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy","volume":"30","author":"Ekberg","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0275","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/thoraxjnl-2015-207140","article-title":"UK Lung Cancer RCT Pilot Screening Trial: Baseline findings from the screening arm provide evidence for the potential implementation of lung cancer screening","volume":"71","author":"Field","year":"2016","journal-title":"Thorax"},{"key":"10.1016\/bs.irn.2016.03.008_bb0280","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1056\/NEJM199807093390202","article-title":"Reversal of lesions of diabetic nephropathy after pancreas transplantation","volume":"339","author":"Fioretto","year":"1998","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0285","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.ecl.2007.07.004","article-title":"Pancreatic islet cell transplant for treatment of diabetes","volume":"36","author":"Fiorina","year":"2007","journal-title":"Endocrinology and Metabolism Clinics of North America"},{"key":"10.1016\/bs.irn.2016.03.008_bb0290","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.amjmed.2012.06.022","article-title":"Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial","volume":"126","author":"Fonseca","year":"2013","journal-title":"The American Journal of Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0295","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S1056-8727(01)00140-4","article-title":"Lipid modulation in insulin-dependent diabetes mellitus: Effect on microvascular outcomes","volume":"15","author":"Fried","year":"2001","journal-title":"Journal of Diabetes and its Complications"},{"key":"10.1016\/bs.irn.2016.03.008_bb0300","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1159\/000056351","article-title":"Tacalcitol, an active vitamin D3, induces nerve growth factor production in human epidermal keratinocytes","volume":"14","author":"Fukuoka","year":"2001","journal-title":"Skin Pharmacology and Applied Skin Physiology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0305","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1056\/NEJMoa0706245","article-title":"Effect of a multifactorial intervention on mortality in type 2 diabetes","volume":"358","author":"Gaede","year":"2008","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0320","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0753-3322(96)82642-4","article-title":"Effects of an aldose reductase inhibitor, epalrestat, on diabetic neuropathy. Clinical benefit and indication for the drug assessed from the results of a placebo-controlled double-blind study","volume":"49","author":"Goto","year":"1995","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/bs.irn.2016.03.008_bb0330","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1212\/WNL.53.3.580","article-title":"Effect of aldose reductase inhibition on nerve conduction and morphometry in diabetic neuropathy. Zenarestat Study Group","volume":"53","author":"Greene","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0335","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/nm834","article-title":"Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy","volume":"9","author":"Hammes","year":"2003","journal-title":"Nature Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0340","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1161\/01.STR.31.9.2080","article-title":"Five-year survival after first-ever stroke and related prognostic factors in the Perth Community Stroke Study","volume":"31","author":"Hankey","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/bs.irn.2016.03.008_bb0345","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0304-3940(91)90114-9","article-title":"Diabetes mellitus-associated decrease in nerve growth factor levels is reversed by allogeneic pancreatic islet transplantation","volume":"125","author":"Hellweg","year":"1991","journal-title":"Neuroscience Letters"},{"key":"10.1016\/bs.irn.2016.03.008_bb0350","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/(SICI)1096-9136(1998120)15:12<1045::AID-DIA696>3.0.CO;2-L","article-title":"Diabetes mellitus in Egypt: Glycaemic control and microvascular and neuropathic complications","volume":"15","author":"Herman","year":"1998","journal-title":"Diabetic Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0355","first-page":"401","article-title":"Effect of rosuvastatin on diabetic polyneuropathy: A randomized, double-blind, placebo-controlled Phase IIa study","volume":"7","author":"Hern\u00e1ndez-Ojeda","year":"2014","journal-title":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"},{"key":"10.1016\/bs.irn.2016.03.008_bb0360","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2337\/dc14-0180","article-title":"Serum 25-hydroxyvitamin D: A predictor of macrovascular and microvascular complications in patients with type 2 diabetes","volume":"38","author":"Herrmann","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0365","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1017\/S0007114511003965","article-title":"Vitamin D status and pain: Analysis from the Health Survey for England among English adults aged 65 years and over","volume":"107","author":"Hirani","year":"2012","journal-title":"The British Journal of Nutrition"},{"key":"10.1016\/bs.irn.2016.03.008_bb0370","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/papr.12342","article-title":"NGF\/TrkA signaling as a therapeutic target for pain","volume":"16","author":"Hirose","year":"2016","journal-title":"Pain Practice"},{"key":"10.1016\/bs.irn.2016.03.008_bb0380","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/dom.12535","article-title":"Burning through the pain: Treatments for diabetic neuropathy","volume":"17","author":"Javed","year":"2015","journal-title":"Diabetes, Obesity & Metabolism"},{"key":"10.1016\/bs.irn.2016.03.008_bb0385","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1900\/RDS.2015.12.63","article-title":"Treating diabetic neuropathy: Present strategies and emerging solutions","volume":"12","author":"Javed","year":"2015","journal-title":"The Review of Diabetic Studies"},{"key":"10.1016\/bs.irn.2016.03.008_bb0390","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neulet.2015.03.037","article-title":"Effects of prostaglandin E1 plus methylcobalamin alone and in combination with lipoic acid on nerve conduction velocity in patients with diabetic peripheral neuropathy: A meta-analysis","volume":"594","author":"Jiang","year":"2015","journal-title":"Neuroscience Letters"},{"key":"10.1016\/bs.irn.2016.03.008_bb0395","doi-asserted-by":"crossref","first-page":"168","DOI":"10.5214\/ans.0972.7531.1118409","article-title":"Painful diabetic neuropathy: An update","volume":"18","author":"Kaur","year":"2011","journal-title":"Annals of Neurosciences"},{"key":"10.1016\/bs.irn.2016.03.008_bb0400","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM199004123221503","article-title":"Effects of pancreatic transplantation on diabetic neuropathy","volume":"322","author":"Kennedy","year":"1990","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0405","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/acn3.186","article-title":"Double-blind, placebo-controlled study of HGF gene therapy in diabetic neuropathy","volume":"2","author":"Kessler","year":"2015","journal-title":"Annals of Clinical and Translational Neurology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0410","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1529-8027.2010.00271.x","article-title":"Intraepidermal nerve fiber density at the distal leg: A worldwide normative reference study","volume":"15","author":"Lauria","year":"2010","journal-title":"Journal of the Peripheral Nervous System"},{"key":"10.1016\/bs.irn.2016.03.008_bb0415","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1468-1331.2010.03023.x","volume":"17","author":"Lauria","year":"2010","journal-title":"European Journal of Neurology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0420","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1212\/01.WNL.0000070781.92512.A4","article-title":"Axonal swellings predict the degeneration of epidermal nerve fibers in painful neuropathies","volume":"61","author":"Lauria","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0425","first-page":"875","article-title":"Skin innervation: Important roles during normal and pathological cutaneous repair","volume":"30","author":"Laverdet","year":"2015","journal-title":"Histology and Histopathology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0430","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1001\/archinte.168.7.771","article-title":"Vitamin D as an analgesic for patients with type 2 diabetes and neuropathic pain","volume":"168","author":"Lee","year":"2008","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0435","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/mus.24243","article-title":"Proficiency of nerve conduction using standard methods and reference values (Cl. NPhys Trial 4)","volume":"50","author":"Litchy","year":"2014","journal-title":"Muscle & Nerve"},{"key":"10.1016\/bs.irn.2016.03.008_bb0440","article-title":"Serum 25-hydroxyvitamin D levels and peripheral neuropathy in patients with type 2 diabetes: a systematic review and meta-analysis","author":"Lv","year":"2014","journal-title":"Journal of Endocrinological Investigation"},{"key":"10.1016\/bs.irn.2016.03.008_bb0450","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.2337\/db14-0492","article-title":"Which test for diagnosing early human diabetic neuropathy?","volume":"63","author":"Malik","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/bs.irn.2016.03.008_bb0455","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S2213-8587(14)70067-1","article-title":"Why are there no good treatments for diabetic neuropathy?","volume":"2","author":"Malik","year":"2014","journal-title":"The Lancet. Diabetes & Endocrinology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0460","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s00125-003-1086-8","article-title":"Corneal confocal microscopy: A non-invasive surrogate of nerve fibre damage and repair in diabetic patients","volume":"46","author":"Malik","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/bs.irn.2016.03.008_bb0465","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/S0140-6736(98)02478-7","article-title":"Effect of angiotensin-converting-enzyme (ACE) inhibitor trandolapril on human diabetic neuropathy: Randomised double-blind controlled trial","volume":"352","author":"Malik","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/bs.irn.2016.03.008_bb0470","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdw022","article-title":"European cancer mortality predictions for the year 2016 with focus on leukaemias","author":"Malvezzi","year":"2016","journal-title":"Annals of Oncology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0475","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/bjc.2015.428","article-title":"Trends in UK regional cancer mortality 1991\u20132007","volume":"114","author":"Marshall","year":"2016","journal-title":"British Journal of Cancer"},{"key":"10.1016\/bs.irn.2016.03.008_bb0480","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1513\/AnnalsATS.201506-388OC","article-title":"Undiagnosed obstructive lung disease in the United States. Associated factors and long-term mortality","volume":"12","author":"Martinez","year":"2015","journal-title":"Annals of the American Thoracic Society"},{"key":"10.1016\/bs.irn.2016.03.008_bb0485","doi-asserted-by":"crossref","first-page":"174","DOI":"10.4158\/EP14332.OR","article-title":"Vitamin D insufficiency is associated with reduced parasympathetic nerve fiber function in type 2 diabetes","volume":"21","author":"Maser","year":"2015","journal-title":"Endocrine Practice"},{"key":"10.1016\/bs.irn.2016.03.008_bb0490","first-page":"S17","article-title":"The use of the Semmes-Weinstein monofilament and other threshold tests for preventing foot ulceration and amputation in persons with diabetes","volume":"49","author":"Mayfield","year":"2000","journal-title":"The Journal of Family Practice"},{"key":"10.1016\/bs.irn.2016.03.008_bb0505","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.2337\/dc07-0870","article-title":"Corneal confocal microscopy detects early nerve regeneration after pancreas transplantation in patients with type 1 diabetes","volume":"30","author":"Mehra","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0510","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/ana.410420509","article-title":"Long-term effects of pancreatic transplantation on diabetic neuropathy","volume":"42","author":"Navarro","year":"1997","journal-title":"Annals of Neurology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0515","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0168-8227(95)01064-K","article-title":"Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study","volume":"28","author":"Ohkubo","year":"1995","journal-title":"Diabetes Research and Clinical Practice"},{"key":"10.1016\/bs.irn.2016.03.008_bb0520","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1046\/j.1464-5491.2002.00801.x","article-title":"The relationship between blood glucose excursions and painful diabetic peripheral neuropathy: A pilot study","volume":"19","author":"Oyibo","year":"2002","journal-title":"Diabetic Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0525","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1167\/iovs.13-13787","article-title":"Rapid automated diagnosis of diabetic peripheral neuropathy with in vivo corneal confocal microscopy","volume":"55","author":"Petropoulos","year":"2014","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/bs.irn.2016.03.008_bb0530","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1097\/ICO.0b013e3182749419","article-title":"Repeatability of in vivo corneal confocal microscopy to quantify corneal nerve morphology","volume":"32","author":"Petropoulos","year":"2013","journal-title":"Cornea"},{"key":"10.1016\/bs.irn.2016.03.008_bb0535","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.2337\/diab.44.12.1355","article-title":"Clinical trials of diabetic neuropathy: Past, present, and future","volume":"44","author":"Pfeifer","year":"1995","journal-title":"Diabetes"},{"key":"10.1016\/bs.irn.2016.03.008_bb0550","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1007\/s00125-013-2942-9","article-title":"Effects of triple antioxidant therapy on measures of cardiovascular autonomic neuropathy and on myocardial blood flow in type 1 diabetes: A randomised controlled trial","volume":"56","author":"Pop-Busui","year":"2013","journal-title":"Diabetologia"},{"key":"10.1016\/bs.irn.2016.03.008_bb0555","doi-asserted-by":"crossref","first-page":"671","DOI":"10.2337\/dc14-2114","article-title":"Corneal confocal microscopy predicts 4-year incident peripheral neuropathy in type 1 diabetes","volume":"38","author":"Pritchard","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0565","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.2337\/db07-0285","article-title":"Surrogate markers of small fiber damage in human diabetic neuropathy","volume":"56","author":"Quattrini","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/bs.irn.2016.03.008_bb0570","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1016\/S0140-6736(09)60698-X","article-title":"Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): A prespecified analysis of a randomised controlled trial","volume":"373","author":"Rajamani","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/bs.irn.2016.03.008_bb0575","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1056\/NEJM199307293290502","article-title":"The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus","volume":"329","author":"Reichard","year":"1993","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0580","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1464-5491.1995.tb00482.x","article-title":"Is ACE inhibition with lisinopril helpful in diabetic neuropathy?","volume":"12","author":"Reja","year":"1995","journal-title":"Diabetic Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0590","doi-asserted-by":"crossref","DOI":"10.1111\/iwj.12289","article-title":"Characteristics of a large cohort of patients with diabetes having at-risk feet and outcomes in patients with foot ulceration referred to a tertiary care diabetes unit","author":"Riaz","year":"2014","journal-title":"International Wound Journal"},{"key":"10.1016\/bs.irn.2016.03.008_bb0595","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/S0140-6736(13)62337-5","article-title":"EMA401, an orally administered highly selective angiotensin II type 2 receptor antagonist, as a novel treatment for postherpetic neuralgia: A randomised, double-blind, placebo-controlled phase 2 clinical trial","volume":"383","author":"Rice","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/bs.irn.2016.03.008_bb0600","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/ana.21675","article-title":"Vascular endothelial growth factor gene transfer for diabetic polyneuropathy: A randomized, double-blinded trial","volume":"65","author":"Ropper","year":"2009","journal-title":"Annals of Neurology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0605","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1161\/HYPERTENSIONAHA.111.174474","article-title":"Effects of manidipine and delapril in hypertensive patients with type 2 diabetes mellitus: The delapril and manidipine for nephroprotection in diabetes (DEMAND) randomized clinical trial","volume":"58","author":"Ruggenenti","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/bs.irn.2016.03.008_bb0610","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000375304","article-title":"Prospective evaluation of the effect of short-term oral vitamin d supplementation on peripheral neuropathy in type 2 diabetes mellitus","volume":"24","author":"Shehab","year":"2015","journal-title":"Medical Principles and Practice"},{"key":"10.1016\/bs.irn.2016.03.008_bb0615","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1464-5491.2011.03510.x","article-title":"Does Vitamin D deficiency play a role in peripheral neuropathy in Type 2 diabetes?","volume":"29","author":"Shehab","year":"2012","journal-title":"Diabetic Medicine"},{"issue":"Suppl. 2","key":"10.1016\/bs.irn.2016.03.008_bb0620","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1111\/jns.12080_3","article-title":"Development of nerve growth factor (NGF) inhibition as a strategy for treatment of pain","volume":"19","author":"Shelton","year":"2014","journal-title":"Journal of the Peripheral Nervous System"},{"key":"10.1016\/bs.irn.2016.03.008_bb0625","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1007\/s00018-003-3084-x","article-title":"New insights into the metabolic and molecular basis for diabetic neuropathy","volume":"60","author":"Sima","year":"2003","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/bs.irn.2016.03.008_bb0630","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1056\/NEJM198809013190905","article-title":"Regeneration and repair of myelinated fibers in sural-nerve biopsy specimens from patients with diabetic neuropathy treated with sorbinil","volume":"319","author":"Sima","year":"1988","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0635","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.2337\/diacare.24.8.1448","article-title":"Increased prevalence of impaired glucose tolerance in patients with painful sensory neuropathy","volume":"24","author":"Singleton","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0640","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1212\/WNL.57.9.1701","article-title":"Epidermal nerve innervation in impaired glucose tolerance and diabetes-associated neuropathy","volume":"57","author":"Smith","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0645","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1464-5491.2011.03379.x","article-title":"Association between vitamin D and diabetic neuropathy in a nationally representative sample: Results from 2001\u20132004 NHANES","volume":"29","author":"Soderstrom","year":"2012","journal-title":"Diabetic Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0650","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1055\/s-2008-1065351","article-title":"Benfotiamine in diabetic polyneuropathy (BENDIP): Results of a randomised, double blind, placebo-controlled clinical study","volume":"116","author":"Stracke","year":"2008","journal-title":"Experimental and Clinical Endocrinology & Diabetes"},{"key":"10.1016\/bs.irn.2016.03.008_bb0655","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","article-title":"Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study","volume":"321","author":"Stratton","year":"2000","journal-title":"BMJ"},{"key":"10.1016\/bs.irn.2016.03.008_bb0660","doi-asserted-by":"crossref","first-page":"968","DOI":"10.2337\/dc10-1675","article-title":"Protection from retinopathy and other complications in patients with type 1 diabetes of extreme duration: The Joslin 50-Year medalist study","volume":"34","author":"Sun","year":"2011","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0665","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1167\/iovs.15-18735","article-title":"Early corneal cellular and nerve fiber pathology in young patients with type 1 diabetes mellitus identified using corneal confocal microscopy","volume":"57","author":"Szalai","year":"2016","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/bs.irn.2016.03.008_bb0670","doi-asserted-by":"crossref","first-page":"13728","DOI":"10.1523\/JNEUROSCI.3637-11.2011","article-title":"Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation","volume":"31","author":"Tague","year":"2011","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/bs.irn.2016.03.008_bb0675","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchemneu.2010.10.001","article-title":"Vitamin D receptor and enzyme expression in dorsal root ganglia of adult female rats: Modulation by ovarian hormones","volume":"41","author":"Tague","year":"2011","journal-title":"Journal of Chemical Neuroanatomy"},{"key":"10.1016\/bs.irn.2016.03.008_bb0685","doi-asserted-by":"crossref","first-page":"838","DOI":"10.2337\/dc14-2311","article-title":"Normative values for corneal nerve morphology assessed using corneal confocal microscopy: A multinational normative data set","volume":"38","author":"Tavakoli","year":"2015","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0690","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/978-1-4614-5441-0_30","article-title":"Pancreatic transplant in diabetes","volume":"771","author":"Tavakoli","year":"2012","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0695","doi-asserted-by":"crossref","first-page":"254","DOI":"10.2337\/db12-0574","article-title":"Corneal confocal microscopy detects early nerve regeneration in diabetic neuropathy after simultaneous pancreas and kidney transplantation","volume":"62","author":"Tavakoli","year":"2013","journal-title":"Diabetes"},{"key":"10.1016\/bs.irn.2016.03.008_bb0700","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2337\/dc10-1303","article-title":"Diabetic neuropathies: Update on definitions, diagnostic criteria, estimation of severity, and treatments","volume":"33","author":"Tesfaye","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0705","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1056\/NEJMoa032782","article-title":"Vascular risk factors and diabetic neuropathy","volume":"352","author":"Tesfaye","year":"2005","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0710","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.2337\/dc07-0608","article-title":"Factors that impact symptomatic diabetic peripheral neuropathy in placebo-administered patients from two 1-year clinical trials","volume":"30","author":"Tesfaye","year":"2007","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0715","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1056\/NEJM199309303291401","article-title":"The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus","volume":"329","author":"The Diabetes Control and Complications Trial Research Group","year":"1993","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0720","doi-asserted-by":"crossref","first-page":"561","DOI":"10.7326\/0003-4819-122-8-199504150-00001","article-title":"The effect of intensive diabetes therapy on the development and progression of neuropathy","volume":"122","author":"The Diabetes Control and Complications Trial Research Group","year":"1995","journal-title":"Annals of Internal Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0725","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1185\/03007995.2015.1103215","article-title":"Nutritional management of patients with diabetic peripheral neuropathy with L-methylfolate-methylcobalamin-pyridoxal-5-phosphate: Results of a real-world patient experience trial","volume":"32","author":"Trippe","year":"2016","journal-title":"Current Medical Research and Opinion"},{"key":"10.1016\/bs.irn.2016.03.008_bb0730","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.2337\/dc09-1428","article-title":"Mortality associated with acute Charcot foot and neuropathic foot ulceration","volume":"33","author":"van Baal","year":"2010","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0735","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.2337\/diacare.28.6.1383","article-title":"Diabetic retinopathy is associated with mortality and cardiovascular disease incidence: The EURODIAB prospective complications study","volume":"28","author":"van Hecke","year":"2005","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0740","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1517\/13543784.2014.892072","article-title":"ARA 290 for treatment of small fiber neuropathy in sarcoidosis","volume":"23","author":"van Velzen","year":"2014","journal-title":"Expert Opinion on Investigational Drugs"},{"key":"10.1016\/bs.irn.2016.03.008_bb0745","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.neuroscience.2013.03.050","article-title":"Therapeutic potential of VEGF and VEGF-derived peptide in peripheral neuropathies","volume":"244","author":"Verheyen","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/bs.irn.2016.03.008_bb0750","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.clinthera.2005.08.001","article-title":"Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial","volume":"27","author":"Vinik","year":"2005","journal-title":"Clinical Therapeutics"},{"key":"10.1016\/bs.irn.2016.03.008_bb0760","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00125-006-0559-y","article-title":"C-peptide is a bioactive peptide","volume":"50","author":"Wahren","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/bs.irn.2016.03.008_bb0765","doi-asserted-by":"crossref","DOI":"10.2337\/dc15-2068","article-title":"Long-acting C-peptide and neuropathy in Type 1 diabetes: A 12-month clinical trial","author":"Wahren","year":"2016","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0770","doi-asserted-by":"crossref","DOI":"10.1111\/dme.13054","article-title":"Association of diabetic foot ulcer and death in a population-based cohort from the United Kingdom","author":"Walsh","year":"2015","journal-title":"Diabetic Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0775","doi-asserted-by":"crossref","first-page":"e26262","DOI":"10.1371\/journal.pone.0026262","article-title":"Dietary vitamin D3 supplements reduce demyelination in the cuprizone model","volume":"6","author":"Wergeland","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/bs.irn.2016.03.008_bb0780","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.2337\/db08-1771","article-title":"Elevated triglycerides correlate with progression of diabetic neuropathy","volume":"58","author":"Wiggin","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/bs.irn.2016.03.008_bb0785","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0140-6736(15)00551-6","article-title":"Cause-specific mortality for 240 causes in China during 1990\u20132013: A systematic subnational analysis for the Global Burden of Disease Study 2013","volume":"387","author":"Zhou","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/bs.irn.2016.03.008_bb0790","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0074-7742(02)50085-4","article-title":"Clinical trials for drugs against diabetic neuropathy: Can we combine scientific needs with clinical practicalities?","volume":"50","author":"Ziegler","year":"2002","journal-title":"International Review of Neurobiology"},{"key":"10.1016\/bs.irn.2016.03.008_bb0795","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2337\/dc09-0545","article-title":"Treatment of symptomatic polyneuropathy with actovegin in type 2 diabetic patients","volume":"32","author":"Ziegler","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/bs.irn.2016.03.008_bb0800","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1464-5491.2004.01109.x","article-title":"Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: A meta-analysis","volume":"21","author":"Ziegler","year":"2004","journal-title":"Diabetic Medicine"},{"key":"10.1016\/bs.irn.2016.03.008_bb0805","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.2337\/db13-1819","article-title":"Early detection of nerve fiber loss by corneal confocal microscopy and skin biopsy in recently diagnosed type 2 diabetes","volume":"63","author":"Ziegler","year":"2014","journal-title":"Diabetes"}],"container-title":["International Review of Neurobiology","Controversies In Diabetic Neuropathy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774216300289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774216300289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T04:11:39Z","timestamp":1655611899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0074774216300289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9780128039151"],"references-count":144,"URL":"https:\/\/doi.org\/10.1016\/bs.irn.2016.03.008","relation":{},"ISSN":["0074-7742"],"issn-type":[{"value":"0074-7742","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}