{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T04:17:39Z","timestamp":1791778659478,"version":"4.3.4"},"reference-count":101,"publisher":"Elsevier","isbn-type":[{"value":"9780128124734","type":"print"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1016\/bs.irn.2017.06.008","type":"book-chapter","created":{"date-parts":[[2017,8,19]],"date-time":"2017-08-19T01:50:17Z","timestamp":1503107417000},"page":"151-175","source":"Crossref","is-referenced-by-count":65,"title":["Substance P and the Neurokinin-1 Receptor: The New CRF"],"prefix":"10.1016","author":[{"given":"Jesse R.","family":"Schank","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Heilig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/bs.irn.2017.06.008_bb0010","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0893-133X(99)00133-5","article-title":"Persistent increase in the motivation to take heroin in rats with a history of drug escalation","volume":"22","author":"Ahmed","year":"2000","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0015","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/cne.902950302","article-title":"Extensive co-occurrence of substance P and dynorphin in striatal projection neurons: An evolutionarily conserved feature of basal ganglia organization","volume":"295","author":"Anderson","year":"1990","journal-title":"The Journal of Comparative Neurology"},{"issue":"1\u20132","key":"10.1016\/bs.irn.2017.06.008_bb0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0891-0618(94)90003-5","article-title":"Quantitative and qualitative aspects on the distribution of 5-HT and its coexistence with substance P and TRH in cat ventral medullary neurons","volume":"7","author":"Arvidsson","year":"1994","journal-title":"Journal of Chemical Neuroanatomy"},{"issue":"23","key":"10.1016\/bs.irn.2017.06.008_bb0025","doi-asserted-by":"crossref","first-page":"4561","DOI":"10.1007\/s00213-014-3605-3","article-title":"Wistar rats acquire and maintain self-administration of 20% ethanol without water deprivation, saccharin\/sucrose fading, or extended access training","volume":"231","author":"Augier","year":"2014","journal-title":"Psychopharmacology"},{"issue":"21","key":"10.1016\/bs.irn.2017.06.008_bb0030","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1111\/bph.13280","article-title":"Neurokinin 1 receptor blockade in the medial amygdala attenuates alcohol drinking in rats with innate anxiety but not in Wistar rats","volume":"172","author":"Ayanwuyi","year":"2015","journal-title":"British Journal of Pharmacology"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0035","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.neulet.2010.03.051","article-title":"Artificial microRNA-based neurokinin-1 receptor gene silencing reduces alcohol consumption in mice","volume":"475","author":"Baek","year":"2010","journal-title":"Neuroscience Letters"},{"issue":"6","key":"10.1016\/bs.irn.2017.06.008_bb0040","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/npp.2012.261","article-title":"The NK1 receptor antagonist L822429 reduces heroin reinforcement","volume":"38","author":"Barbier","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/bs.irn.2017.06.008_bb0045","article-title":"Substance P in the anterior thalamic paraventricular nucleus: Promotion of ethanol drinking in response to orexin from the hypothalamus","author":"Barson","year":"2015","journal-title":"Addiction Biology"},{"issue":"10","key":"10.1016\/bs.irn.2017.06.008_bb0050","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.biopsych.2004.02.007","article-title":"Human positron emission tomography studies of brain neurokinin 1 receptor occupancy by aprepitant","volume":"55","author":"Bergstrom","year":"2004","journal-title":"Biological Psychiatry"},{"issue":"Suppl. 1","key":"10.1016\/bs.irn.2017.06.008_bb0055","doi-asserted-by":"crossref","first-page":"E125","DOI":"10.1111\/j.1530-0277.2012.01923.x","article-title":"TACR1 genotypes predict fMRI response to alcohol cues and level of alcohol dependence","volume":"37","author":"Blaine","year":"2013","journal-title":"Alcoholism, Clinical and Experimental Research"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0060","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00213-013-3120-y","article-title":"The reinstatement model of drug relapse: Recent neurobiological findings, emerging research topics, and translational research","volume":"229","author":"Bossert","year":"2013","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0065","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0028-3908(01)00051-X","article-title":"Intra-amygdala injection of the substance P [NK(1) receptor] antagonist L-760735 inhibits neonatal vocalisations in guinea-pigs","volume":"41","author":"Boyce","year":"2001","journal-title":"Neuropharmacology"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0070","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1073\/pnas.75.3.1582","article-title":"Serotonin and substance P coexist i, neurons of the rat's central nervous system","volume":"75","author":"Chan-Palay","year":"1978","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1\u20132","key":"10.1016\/bs.irn.2017.06.008_bb0075","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0014-2999(83)90445-4","article-title":"Substance P excitation of rat locus coeruleus neurones","volume":"94","author":"Cheeseman","year":"1983","journal-title":"European Journal of Pharmacology"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0080","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0006-8993(00)02494-X","article-title":"Noradrenergic neurons expressing substance P receptor (NK1) in the locus coeruleus complex: A double immunofluorescence study in the rat","volume":"873","author":"Chen","year":"2000","journal-title":"Brain Research"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0085","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.neulet.2009.08.042","article-title":"Coincidence of neurokinin 1 receptor with the vesicular glutamate transporter 3 (VGLUT3) in the rat forebrain","volume":"464","author":"Commons","year":"2009","journal-title":"Neuroscience Letters"},{"issue":"17","key":"10.1016\/bs.irn.2017.06.008_bb0090","doi-asserted-by":"crossref","first-page":"7730","DOI":"10.1523\/JNEUROSCI.22-17-07730.2002","article-title":"Substance P (neurokinin 1) receptor antagonists enhance dorsal raphe neuronal activity","volume":"22","author":"Conley","year":"2002","journal-title":"The Journal of Neuroscience"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0095","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ejphar.2004.08.006","article-title":"The NK(1) receptor antagonist WIN51708 reduces sensitization after chronic cocaine","volume":"499","author":"Davidson","year":"2004","journal-title":"European Journal of Pharmacology"},{"issue":"6674","key":"10.1016\/bs.irn.2017.06.008_bb0100","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/32904","article-title":"Altered nociception, analgesia and aggression in mice lacking the receptor for substance P","volume":"392","author":"De Felipe","year":"1998","journal-title":"Nature"},{"issue":"2","key":"10.1016\/bs.irn.2017.06.008_bb0105","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.bbr.2004.03.020","article-title":"Further evidence on the anxiogenic-like effect of substance P evaluated in the elevated plus-maze in rats","volume":"154","author":"Duarte","year":"2004","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/bs.irn.2017.06.008_bb0110","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1196\/annals.1418.018","article-title":"Substance P in stress and anxiety: NK-1 receptor antagonism interacts with key brain areas of the stress circuitry","volume":"1144","author":"Ebner","year":"2008","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"12","key":"10.1016\/bs.irn.2017.06.008_bb0115","doi-asserted-by":"crossref","first-page":"4280","DOI":"10.1073\/pnas.0400794101","article-title":"Substance P in the medial amygdala: Emotional stress-sensitive release and modulation of anxiety-related behavior in rats","volume":"101","author":"Ebner","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0120","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00726-006-0335-9","article-title":"The role of substance P in stress and anxiety responses","volume":"31","author":"Ebner","year":"2006","journal-title":"Amino Acids"},{"issue":"8","key":"10.1016\/bs.irn.2017.06.008_bb0125","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/sj.npp.1301594","article-title":"Neurokinin 1 receptor antagonism promotes active stress coping via enhanced septal 5-HT transmission","volume":"33","author":"Ebner","year":"2008","journal-title":"Neuropsychopharmacology"},{"issue":"23","key":"10.1016\/bs.irn.2017.06.008_bb0130","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1523\/JNEUROSCI.23-23-08271.2003","article-title":"Neurokinin-1 receptor-expressing neurons in the amygdala modulate morphine reward and anxiety behaviors in the mouse","volume":"23","author":"Gadd","year":"2003","journal-title":"The Journal of Neuroscience"},{"issue":"5869","key":"10.1016\/bs.irn.2017.06.008_bb0135","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1126\/science.1153813","article-title":"Neurokinin 1 receptor antagonism as a possible therapy for alcoholism","volume":"319","author":"George","year":"2008","journal-title":"Science"},{"issue":"5","key":"10.1016\/bs.irn.2017.06.008_bb0140","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.euroneuro.2006.07.004","article-title":"Neurokinin 1 receptor antagonism requires norepinephrine to increase serotonin function","volume":"17","author":"Gobbi","year":"2007","journal-title":"European Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/bs.irn.2017.06.008_bb0145","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1124\/mol.107.040113","article-title":"Substance P neurokinin 1 receptor activation within the dorsal raphe nucleus controls serotonin release in the mouse frontal cortex","volume":"72","author":"Guiard","year":"2007","journal-title":"Molecular Pharmacology"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0150","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0006-8993(77)90144-5","article-title":"Excitation of neurons in the nucleus locus coeruleus by substance P and related peptides","volume":"136","author":"Guyenet","year":"1977","journal-title":"Brain Research"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.brainres.2006.03.026","article-title":"Substance P induces expression of the corticotropin-releasing factor receptor 1 by activation of the neurokinin-1 receptor","volume":"1102","author":"Hamke","year":"2006","journal-title":"Brain Research"},{"issue":"6","key":"10.1016\/bs.irn.2017.06.008_bb0160","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0306-4522(78)90017-9","article-title":"Immunohistochemical evidence of substance P-like immunoreactivity in some 5-hydroxytryptamine-containing neurons in the rat central nervous system","volume":"3","author":"Hokfelt","year":"1978","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0165","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/(SICI)1096-9861(19990816)411:1<56::AID-CNE5>3.0.CO;2-3","article-title":"Preprotachykinin-A mRNA expression in the human and monkey brain: An in situ hybridization study","volume":"411","author":"Hurd","year":"1999","journal-title":"The Journal of Comparative Neurology"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0170","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejphar.2003.10.057","article-title":"Stress-induced increase of cortical dopamine metabolism: Attenuation by a tachykinin NK1 receptor antagonist","volume":"484","author":"Hutson","year":"2004","journal-title":"European Journal of Pharmacology"},{"issue":"2","key":"10.1016\/bs.irn.2017.06.008_bb0175","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/S0026-895X(25)09926-2","article-title":"The species selectivity of chemically distinct tachykinin nonpeptide antagonists is dependent on common divergent residues of the rat and human neurokinin-1 receptors","volume":"45","author":"Jensen","year":"1994","journal-title":"Molecular Pharmacology"},{"issue":"1\u20132","key":"10.1016\/bs.irn.2017.06.008_bb0180","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00213-003-1393-2","article-title":"Brain circuitry and the reinstatement of cocaine-seeking behavior","volume":"168","author":"Kalivas","year":"2003","journal-title":"Psychopharmacology"},{"issue":"8","key":"10.1016\/bs.irn.2017.06.008_bb0185","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1176\/appi.ajp.162.8.1403","article-title":"The neural basis of addiction: A pathology of motivation and choice","volume":"162","author":"Kalivas","year":"2005","journal-title":"The American Journal of Psychiatry"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0190","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.biopsych.2005.07.013","article-title":"Lack of efficacy of the substance p (neurokinin1 receptor) antagonist aprepitant in the treatment of major depressive disorder","volume":"59","author":"Keller","year":"2006","journal-title":"Biological Psychiatry"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0195","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0304-3940(79)90018-1","article-title":"Behavioural activation induced in the rat by substance P infusion into ventral tegmental area: Implication of dopaminergic A10 neurones","volume":"11","author":"Kelley","year":"1979","journal-title":"Neuroscience Letters"},{"key":"10.1016\/bs.irn.2017.06.008_bb0200","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1749-6632.2001.tb03562.x","article-title":"Neurokinin-1 receptor antagonists block acute cocaine-induced horizontal locomotion","volume":"937","author":"Kraft","year":"2001","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/bs.irn.2017.06.008_bb0205","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1749-6632.2001.tb03561.x","article-title":"Substance P modulates cocaine-evoked dopamine overflow in the striatum of the rat brain","volume":"937","author":"Kraft","year":"2001","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"5383","key":"10.1016\/bs.irn.2017.06.008_bb0210","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1126\/science.281.5383.1640","article-title":"Distinct mechanism for antidepressant activity by blockade of central substance P receptors","volume":"281","author":"Kramer","year":"1998","journal-title":"Science"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0215","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00213-014-3665-4","article-title":"The neurokinin-1 receptor antagonist aprepitant in co-morbid alcohol dependence and posttraumatic stress disorder: A human experimental study","volume":"232","author":"Kwako","year":"2015","journal-title":"Psychopharmacology"},{"issue":"11","key":"10.1016\/bs.irn.2017.06.008_bb0220","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1111\/j.1460-9568.2006.04833.x","article-title":"Immunocytochemical evidence for the existence of substance P receptor (NK1) in serotonin neurons of rat and mouse dorsal raphe nucleus","volume":"23","author":"Lacoste","year":"2006","journal-title":"The European Journal of Neuroscience"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0225","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/cne.903550308","article-title":"D1 and D2 dopamine receptor gene expression in the rat striatum: Sensitive cRNA probes demonstrate prominent segregation of D1 and D2 mRNAs in distinct neuronal populations of the dorsal and ventral striatum","volume":"355","author":"Le Moine","year":"1995","journal-title":"The Journal of Comparative Neurology"},{"issue":"9","key":"10.1016\/bs.irn.2017.06.008_bb0230","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.bcp.2009.01.020","article-title":"Characterization of species-related differences in the pharmacology of tachykinin NK receptors 1, 2 and 3","volume":"77","author":"Leffler","year":"2009","journal-title":"Biochemical Pharmacology"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0235","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0306-4522(97)00327-8","article-title":"Expression of D1 receptor, D2 receptor, substance P and enkephalin messenger RNAs in the neurons projecting from the nucleus accumbens","volume":"82","author":"Lu","year":"1998","journal-title":"Neuroscience"},{"issue":"14","key":"10.1016\/bs.irn.2017.06.008_bb0240","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1097\/00001756-200210070-00024","article-title":"Modulation of brain stem monoamines and gamma-aminobutyric acid by NK1 receptors in rats","volume":"13","author":"Ma","year":"2002","journal-title":"Neuroreport"},{"issue":"Suppl. 11","key":"10.1016\/bs.irn.2017.06.008_bb0245","first-page":"6","article-title":"Neurobiology of substance P and the NK1 receptor","volume":"63","author":"Mantyh","year":"2002","journal-title":"The Journal of Clinical Psychiatry"},{"issue":"1\u20132","key":"10.1016\/bs.irn.2017.06.008_bb0250","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0006-8993(84)90470-0","article-title":"Substance P receptors: Localization by light microscopic autoradiography in rat brain using [3H]SP as the radioligand","volume":"307","author":"Mantyh","year":"1984","journal-title":"Brain Research"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0255","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.euroneuro.2010.11.012","article-title":"A selective neurokinin-1 receptor antagonist in chronic PTSD: A randomized, double-blind, placebo-controlled, proof-of-concept trial","volume":"21","author":"Mathew","year":"2011","journal-title":"European Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/bs.irn.2017.06.008_bb0260","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bbr.2007.04.010","article-title":"Involvement of NK1 receptors in metabolic stress markers after the central administration of substance P","volume":"181","author":"Mello","year":"2007","journal-title":"Behavioural Brain Research"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0265","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1461145712000065","article-title":"Lack of efficacy of L-759274, a novel neurokinin 1 (substance P) receptor antagonist, for the treatment of generalized anxiety disorder","volume":"16","author":"Michelson","year":"2013","journal-title":"The International Journal of Neuropsychopharmacology"},{"issue":"6783","key":"10.1016\/bs.irn.2017.06.008_bb0270","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/35012069","article-title":"Rewarding effects of opiates are absent in mice lacking the receptor for substance P","volume":"405","author":"Murtra","year":"2000","journal-title":"Nature"},{"key":"10.1016\/bs.irn.2017.06.008_bb0275","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12494","article-title":"Bidirectional relationship between alcohol intake and sensitivity to social defeat: Association with Tacr1 and Avp expression","author":"Nelson","year":"2017","journal-title":"Addiction Biology"},{"key":"10.1016\/bs.irn.2017.06.008_bb0280","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1749-6632.2002.tb04168.x","article-title":"Neurokinin receptors modulate the neurochemical actions of cocaine","volume":"965","author":"Noailles","year":"2002","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"12","key":"10.1016\/bs.irn.2017.06.008_bb0285","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1016\/j.lfs.2003.09.039","article-title":"Tachykinins and tachykinin receptors: A growing family","volume":"74","author":"Pennefather","year":"2004","journal-title":"Life Sciences"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0290","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/1096-9861(20000731)423:3<500::AID-CNE12>3.0.CO;2-9","article-title":"Neurokinin 1 receptor distribution in cholinergic neurons and targets of substance P terminals in the rat nucleus accumbens","volume":"423","author":"Pickel","year":"2000","journal-title":"The Journal of Comparative Neurology"},{"issue":"1\u20132","key":"10.1016\/bs.irn.2017.06.008_bb0295","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00213-004-1912-9","article-title":"Infusion of the substance P analogue, DiMe-C7, into the ventral tegmental area induces reinstatement of cocaine-seeking behaviour in rats","volume":"177","author":"Placenza","year":"2004","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0300","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.pbb.2006.04.011","article-title":"Effects of central neurokinin-1 receptor antagonism on cocaine- and opiate-induced locomotor activity and self-administration behaviour in rats","volume":"84","author":"Placenza","year":"2006","journal-title":"Pharmacology, Biochemistry, and Behavior"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0305","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neulet.2005.07.050","article-title":"Activation of central neurokinin-1 receptors induces reinstatement of cocaine-seeking behavior","volume":"390","author":"Placenza","year":"2005","journal-title":"Neuroscience Letters"},{"issue":"5919","key":"10.1016\/bs.irn.2017.06.008_bb0310","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/303714a0","article-title":"Autoradiographic distribution of substance P receptors in rat central nervous system","volume":"303","author":"Quirion","year":"1983","journal-title":"Nature"},{"issue":"6","key":"10.1016\/bs.irn.2017.06.008_bb0315","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/JCP.0b013e31823608ca","article-title":"Results from 2 randomized, double-blind, placebo-controlled studies of the novel NK1 receptor antagonist casopitant in patients with major depressive disorder","volume":"31","author":"Ratti","year":"2011","journal-title":"Journal of Clinical Psychopharmacology"},{"issue":"5","key":"10.1016\/bs.irn.2017.06.008_bb0320","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1177\/0269881113480990","article-title":"Full central neurokinin-1 receptor blockade is required for efficacy in depression: Evidence from orvepitant clinical studies","volume":"27","author":"Ratti","year":"2013","journal-title":"Journal of Psychopharmacology"},{"issue":"5","key":"10.1016\/bs.irn.2017.06.008_bb0325","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/jnr.20997","article-title":"Blockade of tachykinin NK1 receptors attenuates stress-induced rise of extracellular noradrenaline and dopamine in the rat and gerbil medial prefrontal cortex","volume":"84","author":"Renoldi","year":"2006","journal-title":"Journal of Neuroscience Research"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0330","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1177\/0269881113517953","article-title":"Characterising the plasma-target occupancy relationship of the neurokinin antagonist GSK1144814 with PET","volume":"28","author":"Ridler","year":"2014","journal-title":"Journal of Psychopharmacology"},{"issue":"8","key":"10.1016\/bs.irn.2017.06.008_bb0335","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/S0028-3908(02)00295-2","article-title":"Lack of self-administration and behavioural sensitisation to morphine, but not cocaine, in mice lacking NK1 receptors","volume":"43","author":"Ripley","year":"2002","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0340","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00213-011-2469-z","article-title":"Potentiation of brain stimulation reward by morphine: Effects of neurokinin-1 receptor antagonism","volume":"220","author":"Robinson","year":"2012","journal-title":"Psychopharmacology"},{"issue":"21","key":"10.1016\/bs.irn.2017.06.008_bb0345","doi-asserted-by":"crossref","first-page":"8491","DOI":"10.1523\/JNEUROSCI.17-21-08491.1997","article-title":"Persistent structural modifications in nucleus accumbens and prefrontal cortex neurons produced by previous experience with amphetamine","volume":"17","author":"Robinson","year":"1997","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"10.1016\/bs.irn.2017.06.008_bb0350","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S0028-3908(03)00023-6","article-title":"The substance P (NK1) receptor antagonist L-760735 inhibits fear conditioning in gerbils","volume":"44","author":"Rupniak","year":"2003","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/bs.irn.2017.06.008_bb0355","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1073\/pnas.98.4.1912","article-title":"Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function","volume":"98","author":"Santarelli","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0360","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1124\/jpet.113.210799","article-title":"The neurokinin-1 receptor in addictive processes","volume":"351","author":"Schank","year":"2014","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"issue":"5","key":"10.1016\/bs.irn.2017.06.008_bb0365","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/npp.2013.309","article-title":"The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking","volume":"39","author":"Schank","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/bs.irn.2017.06.008_bb0370","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.neuropharm.2015.07.009","article-title":"Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking","volume":"99","author":"Schank","year":"2015","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0375","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00213-011-2201-z","article-title":"Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429","volume":"218","author":"Schank","year":"2011","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0380","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.neuron.2012.09.026","article-title":"Stress-related neuropeptides and addictive behaviors: Beyond the usual suspects","volume":"76","author":"Schank","year":"2012","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/bs.irn.2017.06.008_bb0385","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.biopsych.2012.12.027","article-title":"Tacr1 gene variation and neurokinin 1 receptor expression is associated with antagonist efficacy in genetically selected alcohol-preferring rats","volume":"73","author":"Schank","year":"2013","journal-title":"Biological Psychiatry"},{"issue":"11","key":"10.1016\/bs.irn.2017.06.008_bb0390","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1038\/npp.2009.65","article-title":"Susceptibility locus in neurokinin-1 receptor gene associated with alcohol dependence","volume":"34","author":"Seneviratne","year":"2009","journal-title":"Neuropsychopharmacology"},{"issue":"18","key":"10.1016\/bs.irn.2017.06.008_bb0395","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1097\/00001756-199912160-00044","article-title":"Serotonin and substance P co-exist in dorsal raphe neurons of the human brain","volume":"10","author":"Sergeyev","year":"1999","journal-title":"Neuroreport"},{"issue":"1\u20132","key":"10.1016\/bs.irn.2017.06.008_bb0400","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00213-002-1224-x","article-title":"The reinstatement model of drug relapse: History, methodology and major findings","volume":"168","author":"Shaham","year":"2003","journal-title":"Psychopharmacology"},{"issue":"4","key":"10.1016\/bs.irn.2017.06.008_bb0405","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/ajmg.b.32241","article-title":"Genetic association of the tachykinin receptor 1 TACR1 gene in bipolar disorder, attention deficit hyperactivity disorder, and the alcohol dependence syndrome","volume":"165B","author":"Sharp","year":"2014","journal-title":"American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics"},{"issue":"6","key":"10.1016\/bs.irn.2017.06.008_bb0410","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/0196-9781(84)90177-3","article-title":"A comparison of the anatomical distribution of substance P and substance P receptors in the rat central nervous system","volume":"5","author":"Shults","year":"1984","journal-title":"Peptides"},{"issue":"10","key":"10.1016\/bs.irn.2017.06.008_bb0415","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/j.1530-0277.2008.00753.x","article-title":"Intermittent access to 20% ethanol induces high ethanol consumption in long-Evans and Wistar rats","volume":"32","author":"Simms","year":"2008","journal-title":"Alcoholism, Clinical and Experimental Research"},{"issue":"6","key":"10.1016\/bs.irn.2017.06.008_bb0420","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1111\/j.1471-4159.2008.05596.x","article-title":"Modulation of basal and stress-induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L-822429","volume":"106","author":"Singewald","year":"2008","journal-title":"Journal of Neurochemistry"},{"issue":"4","key":"10.1016\/bs.irn.2017.06.008_bb0425","doi-asserted-by":"crossref","first-page":"2500","DOI":"10.1152\/jn.00883.2014","article-title":"Substance P excites GABAergic neurons in the mouse central amygdala through neurokinin 1 receptor activation","volume":"114","author":"Sosulina","year":"2015","journal-title":"Journal of Neurophysiology"},{"issue":"9","key":"10.1016\/bs.irn.2017.06.008_bb0430","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012527","article-title":"The neurokinin 1 receptor antagonist, ezlopitant, reduces appetitive responding for sucrose and ethanol","volume":"5","author":"Steensland","year":"2010","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0435","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1152\/physrev.00031.2013","article-title":"Tachykinins and their receptors: Contributions to physiological control and the mechanisms of disease","volume":"94","author":"Steinhoff","year":"2014","journal-title":"Physiological Reviews"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0440","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0014-2999(96)00390-1","article-title":"Effects of central administration of tachykinin receptor agonists and antagonists on plus-maze behavior in mice","volume":"311","author":"Teixeira","year":"1996","journal-title":"European Journal of Pharmacology"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0445","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00213-010-1775-1","article-title":"Neurokinin-1 receptors (NK1R:s), alcohol consumption, and alcohol reward in mice","volume":"209","author":"Thorsell","year":"2010","journal-title":"Psychopharmacology"},{"issue":"6","key":"10.1016\/bs.irn.2017.06.008_bb0450","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3109\/10799893.2013.843194","article-title":"Why receptor reserve matters for neurokinin1 (NK1) receptor antagonists","volume":"33","author":"Trist","year":"2013","journal-title":"Journal of Receptor and Signal Transduction Research"},{"issue":"18","key":"10.1016\/bs.irn.2017.06.008_bb0455","doi-asserted-by":"crossref","first-page":"7155","DOI":"10.1523\/JNEUROSCI.23-18-07155.2003","article-title":"Substance P acts through local circuits within the rat dorsal raphe nucleus to alter serotonergic neuronal activity","volume":"23","author":"Valentino","year":"2003","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0460","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/cne.903510111","article-title":"Dynorphin-immunoreactive neurons in the rat nucleus accumbens: Ultrastructure and synaptic input from terminals containing substance P and\/or dynorphin","volume":"351","author":"Van Bockstaele","year":"1995","journal-title":"The Journal of Comparative Neurology"},{"issue":"2","key":"10.1016\/bs.irn.2017.06.008_bb0465","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1369-1600.2011.00419.x","article-title":"Effects of the NK1 antagonist, aprepitant, on response to oral and intranasal oxycodone in prescription opioid abusers","volume":"18","author":"Walsh","year":"2013","journal-title":"Addiction Biology"},{"issue":"4","key":"10.1016\/bs.irn.2017.06.008_bb0470","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1002\/jnr.10873","article-title":"A non-peptide substance P antagonist (CP-96,345) inhibits morphine-induced NF-kappa B promoter activation in human NT2-N neurons","volume":"75","author":"Wang","year":"2004","journal-title":"Journal of Neuroscience Research"},{"issue":"3","key":"10.1016\/bs.irn.2017.06.008_bb0475","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/BF00414034","article-title":"Voluntary ethanol intake in rats following exposure to ethanol on various schedules","volume":"29","author":"Wise","year":"1973","journal-title":"Psychopharmacologia"},{"issue":"4","key":"10.1016\/bs.irn.2017.06.008_bb0480","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1113\/expphysiol.2007.037457","article-title":"Activation of paraventricular nucleus neurones by the dorsomedial hypothalamus via a tachykinin pathway in rats","volume":"92","author":"Womack","year":"2007","journal-title":"Experimental Physiology"},{"issue":"11","key":"10.1016\/bs.irn.2017.06.008_bb0485","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1161\/CIRCRESAHA.107.153494","article-title":"Substance P targets sympathetic control neurons in the paraventricular nucleus","volume":"100","author":"Womack","year":"2007","journal-title":"Circulation Research"},{"key":"10.1016\/bs.irn.2017.06.008_bb0490","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainresbull.2013.10.007","article-title":"Substance P receptor antagonist in lateral habenula improves rat depression-like behavior","volume":"100","author":"Yang","year":"2014","journal-title":"Brain Research Bulletin"},{"issue":"11","key":"10.1016\/bs.irn.2017.06.008_bb0495","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1046\/j.1440-1681.2000.03366.x","article-title":"Localization of tachykinin receptors and Fos-like immunoreactivity induced by substance P in guinea-pig brain","volume":"27","author":"Yip","year":"2000","journal-title":"Clinical and Experimental Pharmacology & Physiology"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0500","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1523\/JNEUROSCI.4315-08.2009","article-title":"Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons","volume":"29","author":"Yu","year":"2009","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2017.06.008_bb0505","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbr.2010.11.049","article-title":"Involvement of p38\/NF-kappaB signaling pathway in the nucleus accumbens in the rewarding effects of morphine in rats","volume":"218","author":"Zhang","year":"2011","journal-title":"Behavioural Brain Research"},{"issue":"2","key":"10.1016\/bs.irn.2017.06.008_bb0510","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/npp.2008.55","article-title":"Effects of substance P in the amygdala, ventromedial hypothalamus, and periaqueductal gray on fear-potentiated startle","volume":"34","author":"Zhao","year":"2009","journal-title":"Neuropsychopharmacology"}],"container-title":["International Review of Neurobiology","The Role of Neuropeptides in Addiction and Disorders of Excessive Consumption"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774217301034?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774217301034?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T23:34:04Z","timestamp":1750808044000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0074774217301034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9780128124734"],"references-count":101,"URL":"https:\/\/doi.org\/10.1016\/bs.irn.2017.06.008","relation":{},"ISSN":["0074-7742"],"issn-type":[{"value":"0074-7742","type":"print"}],"subject":[],"published":{"date-parts":[[2017]]}}}