{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:49:17Z","timestamp":1790693357648,"version":"4.1.0"},"reference-count":132,"publisher":"Elsevier","isbn-type":[{"value":"9780128200766","type":"print"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1016\/bs.irn.2020.02.002","type":"book-chapter","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T22:48:37Z","timestamp":1594421317000},"page":"131-151","source":"Crossref","is-referenced-by-count":33,"title":["APOE and metabolic dysfunction in Alzheimer's disease"],"prefix":"10.1016","member":"78","reference":[{"issue":"6","key":"10.1016\/bs.irn.2020.02.002_bb0010","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1002\/pon.742","article-title":"The relationship of APOE genotype to neuropsychological performance in long-term cancer survivors treated with standard dose chemotherapy","volume":"12","author":"Ahles","year":"2003","journal-title":"Psychooncology"},{"issue":"9","key":"10.1016\/bs.irn.2020.02.002_bb0015","doi-asserted-by":"crossref","first-page":"3326","DOI":"10.1523\/JNEUROSCI.5098-09.2010","article-title":"Amyloid-beta aggregates cause alterations of astrocytic metabolic phenotype: Impact on neuronal viability","volume":"30","author":"Allaman","year":"2010","journal-title":"The Journal of Neuroscience"},{"issue":"9","key":"10.1016\/bs.irn.2020.02.002_bb0020","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1471-4159.1966.tb05874.x","article-title":"The oxidation of uniformly labelled albumin-bound palmitic acid to CO2 by the perfused cat brain","volume":"13","author":"Allweis","year":"1966","journal-title":"Journal of Neurochemistry"},{"issue":"Pt. 12","key":"10.1016\/bs.irn.2020.02.002_bb0025","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.1093\/brain\/awv278","article-title":"Regional brain hypometabolism is unrelated to regional amyloid plaque burden","volume":"138","author":"Altmann","year":"2015","journal-title":"Brain"},{"issue":"10","key":"10.1016\/bs.irn.2020.02.002_bb0030","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1096\/fj.10-159517","article-title":"Impaired adipogenic response to thiazolidinediones in mice expressing human apolipoproteinE4","volume":"24","author":"Arbones-Mainar","year":"2010","journal-title":"The FASEB Journal"},{"issue":"10","key":"10.1016\/bs.irn.2020.02.002_bb0035","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1038\/ijo.2008.143","article-title":"Differential modulation of diet-induced obesity and adipocyte functionality by human apolipoprotein E3 and E4 in mice","volume":"32","author":"Arbones-Mainar","year":"2008","journal-title":"International Journal of Obesity"},{"issue":"10","key":"10.1016\/bs.irn.2020.02.002_bb0040","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1038\/ijo.2016.93","article-title":"Metabolic shifts toward fatty-acid usage and increased thermogenesis are associated with impaired adipogenesis in mice expressing human APOE4","volume":"40","author":"Arbones-Mainar","year":"2016","journal-title":"International Journal of Obesity"},{"issue":"4","key":"10.1016\/bs.irn.2020.02.002_bb0045","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1111\/j.1471-4159.1991.tb11435.x","article-title":"Fatty acid oxidation and ketogenesis by astrocytes in primary culture","volume":"56","author":"Auestad","year":"1991","journal-title":"Journal of Neurochemistry"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0050","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/archpsyc.63.1.63","article-title":"Apolipoprotein E genotype and age-related myelin breakdown in healthy individuals: Implications for cognitive decline and dementia","volume":"63","author":"Bartzokis","year":"2006","journal-title":"Archives of General Psychiatry"},{"issue":"12","key":"10.1016\/bs.irn.2020.02.002_bb0055","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/j.biopsych.2007.03.024","article-title":"Apolipoprotein E affects both myelin breakdown and cognition: Implications for age-related trajectories of decline into dementia","volume":"62","author":"Bartzokis","year":"2007","journal-title":"Biological Psychiatry"},{"issue":"11","key":"10.1016\/bs.irn.2020.02.002_bb0060","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1001\/jama.298.11.1300","article-title":"Association of apolipoprotein E genotypes with lipid levels and coronary risk","volume":"298","author":"Bennet","year":"2007","journal-title":"JAMA"},{"issue":"47","key":"10.1016\/bs.irn.2020.02.002_bb0065","first-page":"E4502","article-title":"Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease","volume":"110","author":"Benzinger","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0070","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/ng1934","article-title":"Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database","volume":"39","author":"Bertram","year":"2007","journal-title":"Nature Genetics"},{"issue":"R2","key":"10.1016\/bs.irn.2020.02.002_bb0075","doi-asserted-by":"crossref","first-page":"R137","DOI":"10.1093\/hmg\/ddp406","article-title":"Genome-wide association studies in Alzheimer's disease","volume":"18","author":"Bertram","year":"2009","journal-title":"Human Molecular Genetics"},{"issue":"6","key":"10.1016\/bs.irn.2020.02.002_bb0080","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/S0197-4580(02)00036-2","article-title":"Alzheimer's disease and Alzheimer's dementia: Distinct but overlapping entities","volume":"23","author":"Blass","year":"2002","journal-title":"Neurobiology of Aging"},{"issue":"7","key":"10.1016\/bs.irn.2020.02.002_bb0085","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0891-5849(96)00240-7","article-title":"Nitric oxide-mediated mitochondrial damage: A potential neuroprotective role for glutathione","volume":"21","author":"Bolanos","year":"1996","journal-title":"Free Radical Biology & Medicine"},{"key":"10.1016\/bs.irn.2020.02.002_bb0090","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3389\/fnagi.2018.00180","article-title":"APOE and Alzheimer's disease: Neuroimaging of metabolic and cerebrovascular dysfunction","volume":"10","author":"Brandon","year":"2018","journal-title":"Frontiers in Aging Neuroscience"},{"key":"10.1016\/bs.irn.2020.02.002_bb0095","doi-asserted-by":"crossref","first-page":"13842","DOI":"10.1038\/srep13842","article-title":"Differential interaction of Apolipoprotein-E isoforms with insulin receptors modulates brain insulin signaling in mutant human amyloid precursor protein transgenic mice","volume":"5","author":"Chan","year":"2015","journal-title":"Scientific Reports"},{"key":"10.1016\/bs.irn.2020.02.002_bb0100","doi-asserted-by":"crossref","first-page":"26119","DOI":"10.1038\/srep26119","article-title":"ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Abeta impairment of insulin signaling in an Alzheimer's disease mouse model","volume":"6","author":"Chan","year":"2016","journal-title":"Scientific Reports"},{"issue":"22","key":"10.1016\/bs.irn.2020.02.002_bb0105","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1212\/WNL.0b013e3181ffe4d1","article-title":"Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects","volume":"75","author":"Chiang","year":"2010","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/bs.irn.2020.02.002_bb0110","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1017\/S0007114513001268","article-title":"Disturbance in uniformly 13C-labelled DHA metabolism in elderly human subjects carrying the apoE epsilon4 allele","volume":"110","author":"Chouinard-Watkins","year":"2013","journal-title":"The British Journal of Nutrition"},{"issue":"5","key":"10.1016\/bs.irn.2020.02.002_bb0115","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1212\/WNL.0000000000001820","article-title":"Inflammation-associated declines in cerebral vasoreactivity and cognition in type 2 diabetes","volume":"85","author":"Chung","year":"2015","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/bs.irn.2020.02.002_bb0120","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng0694-180","article-title":"Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease","volume":"7","author":"Corder","year":"1994","journal-title":"Nature Genetics"},{"issue":"2","key":"10.1016\/bs.irn.2020.02.002_bb0125","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s11060-006-9212-3","article-title":"Cognitive functions in low-grade gliomas: Disease and treatment effects","volume":"81","author":"Correa","year":"2007","journal-title":"Journal of Neuro-Oncology"},{"issue":"4","key":"10.1016\/bs.irn.2020.02.002_bb0130","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1212\/WNL.0000000000000617","article-title":"APOE polymorphisms and cognitive functions in patients with brain tumors","volume":"83","author":"Correa","year":"2014","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/bs.irn.2020.02.002_bb0135","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1093\/neuonc\/noz094","article-title":"Genetic variants and cognitive functions in patients with brain tumors","volume":"21","author":"Correa","year":"2019","journal-title":"Neuro-Oncology"},{"issue":"3","key":"10.1016\/bs.irn.2020.02.002_bb0140","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/archneurol.2009.27","article-title":"The role of metabolic disorders in Alzheimer disease and vascular dementia: Two roads converged","volume":"66","author":"Craft","year":"2009","journal-title":"Archives of Neurology"},{"key":"10.1016\/bs.irn.2020.02.002_bb0145","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1749-6632.2000.tb06371.x","article-title":"Insulin effects on glucose metabolism, memory, and plasma amyloid precursor protein in Alzheimer's disease differ according to apolipoprotein-E genotype","volume":"903","author":"Craft","year":"2000","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"19","key":"10.1016\/bs.irn.2020.02.002_bb0150","doi-asserted-by":"crossref","first-page":"10966","DOI":"10.1073\/pnas.191044198","article-title":"Prediction of cognitive decline in normal elderly subjects with 2-[(18)F]fluoro-2-deoxy-D-glucose\/poitron-emission tomography (FDG\/PET)","volume":"98","author":"de Leon","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"10.1016\/bs.irn.2020.02.002_bb0155","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.trci.2017.06.002","article-title":"Lower brain and blood nutrient status in Alzheimer's disease: Results from meta-analyses","volume":"3","author":"de Wilde","year":"2017","journal-title":"Alzheimer's & dementia: Translational Research & Clinical Interventions"},{"issue":"6","key":"10.1016\/bs.irn.2020.02.002_bb0160","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s10522-012-9403-6","article-title":"An inverse-Warburg effect and the origin of Alzheimer's disease","volume":"13","author":"Demetrius","year":"2012","journal-title":"Biogerontology"},{"issue":"2","key":"10.1016\/bs.irn.2020.02.002_bb0165","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/0005-2760(70)90169-4","article-title":"Fatty acid uptake by the brain. 3. Incorporation of (1-14C)oleic acid into the adult rat brain","volume":"210","author":"Dhopeshwarkar","year":"1970","journal-title":"Biochimica et Biophysica Acta"},{"issue":"4","key":"10.1016\/bs.irn.2020.02.002_bb0170","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s11745-006-1390-4","article-title":"Associations between apolipoprotein E genotype and circulating F2-isoprostane levels in humans","volume":"40","author":"Dietrich","year":"2005","journal-title":"Lipids"},{"issue":"12","key":"10.1016\/bs.irn.2020.02.002_bb0175","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1007\/s00125-009-1497-2","article-title":"Presence of the APOE epsilon4 allele modifies the relationship between type 2 diabetes and cognitive performance: The Maine-Syracuse Study","volume":"52","author":"Dore","year":"2009","journal-title":"Diabetologia"},{"issue":"12","key":"10.1016\/bs.irn.2020.02.002_bb0180","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1016\/S0022-2275(20)34454-0","article-title":"Extrahepatic synthesis of apolipoprotein E","volume":"25","author":"Driscoll","year":"1984","journal-title":"Journal of Lipid Research"},{"issue":"5","key":"10.1016\/bs.irn.2020.02.002_bb0185","first-page":"267","article-title":"Apolipoprotein E polymorphism in Turkish subjects with type 2 diabetes mellitus: Allele frequency and relation to serum lipid concentrations","volume":"17","author":"Duman","year":"2004","journal-title":"Diabetes, Nutrition & Metabolism"},{"issue":"13","key":"10.1016\/bs.irn.2020.02.002_bb0190","doi-asserted-by":"crossref","first-page":"5928","DOI":"10.1523\/JNEUROSCI.23-13-05928.2003","article-title":"Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy","volume":"23","author":"Ebert","year":"2003","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"10.1016\/bs.irn.2020.02.002_bb0195","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/jnr.490180407","article-title":"Capacity for substrate utilization in oxidative metabolism by neurons, astrocytes, and oligodendrocytes from developing brain in primary culture","volume":"18","author":"Edmond","year":"1987","journal-title":"Journal of Neuroscience Research"},{"issue":"6","key":"10.1016\/bs.irn.2020.02.002_bb0200","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1093\/aje\/155.6.487","article-title":"Apolipoprotein E polymorphism and cardiovascular disease: A HuGE review","volume":"155","author":"Eichner","year":"2002","journal-title":"American Journal of Epidemiology"},{"issue":"12","key":"10.1016\/bs.irn.2020.02.002_bb0205","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/oby.2003.201","article-title":"Obesity modulates the association among APOE genotype, insulin, and glucose in men","volume":"11","author":"Elosua","year":"2003","journal-title":"Obesity Research"},{"issue":"10","key":"10.1016\/bs.irn.2020.02.002_bb0210","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S0899-9007(02)00916-4","article-title":"Free radicals, antioxidants, and nutrition","volume":"18","author":"Fang","year":"2002","journal-title":"Nutrition"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0215","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/MOL.0000000000000566","article-title":"Effects of apolipoprotein E on nutritional metabolism in dementia","volume":"30","author":"Farmer","year":"2019","journal-title":"Current Opinion in Lipidology"},{"issue":"2","key":"10.1016\/bs.irn.2020.02.002_bb0220","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3390\/cells8020182","article-title":"Apolipoprotein E4 alters astrocyte fatty acid metabolism and lipid droplet formation","volume":"8","author":"Farmer","year":"2019","journal-title":"Cell"},{"issue":"16","key":"10.1016\/bs.irn.2020.02.002_bb0225","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0230","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.neuroimage.2010.08.009","article-title":"Differential effects of the APOE genotype on brain function across the lifespan","volume":"54","author":"Filippini","year":"2011","journal-title":"NeuroImage"},{"issue":"6","key":"10.1016\/bs.irn.2020.02.002_bb0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0100519","article-title":"Human cerebrospinal fluid fatty acid levels differ between supernatant fluid and brain-derived nanoparticle fractions, and are altered in Alzheimer's disease","volume":"9","author":"Fonteh","year":"2014","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/bs.irn.2020.02.002_bb0240","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.2337\/db16-1278","article-title":"Disruption of lipid uptake in Astroglia exacerbates diet-induced obesity","volume":"66","author":"Gao","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/bs.irn.2020.02.002_bb0245","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.exger.2014.02.004","article-title":"ApoE gene and exceptional longevity: Insights from three independent cohorts","volume":"53","author":"Garatachea","year":"2014","journal-title":"Experimental Gerontology"},{"issue":"5","key":"10.1016\/bs.irn.2020.02.002_bb0250","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.neurobiolaging.2007.08.019","article-title":"The effects of normal aging and ApoE genotype on the levels of CSF biomarkers for Alzheimer's disease","volume":"30","author":"Glodzik-Sobanska","year":"2009","journal-title":"Neurobiology of Aging"},{"issue":"10","key":"10.1016\/bs.irn.2020.02.002_bb0255","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1212\/WNL.36.10.1390","article-title":"Stability of metabolic and neuropsychological asymmetries in dementia of the Alzheimer type","volume":"36","author":"Grady","year":"1986","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/bs.irn.2020.02.002_bb0260","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1212\/WNL.0000000000003585","article-title":"Multimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load","volume":"88","author":"Grothe","year":"2017","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/bs.irn.2020.02.002_bb0265","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1159\/000297742","article-title":"Longitudinal examination of obesity and cognitive function: Results from the Baltimore longitudinal study of aging","volume":"34","author":"Gunstad","year":"2010","journal-title":"Neuroepidemiology"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0270","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3233\/JAD-150273","article-title":"Differential effects of meal challenges on cognition, metabolism, and biomarkers for apolipoprotein E varepsilon4 carriers and adults with mild cognitive impairment","volume":"48","author":"Hanson","year":"2015","journal-title":"Journal of Alzheimer's Disease"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0275","doi-asserted-by":"crossref","first-page":"114","DOI":"10.2174\/1381612820666141020164222","article-title":"The APOE genotype: Modification of therapeutic responses in Alzheimer's disease","volume":"21","author":"Hanson","year":"2015","journal-title":"Current Pharmaceutical Design"},{"issue":"10","key":"10.1016\/bs.irn.2020.02.002_bb0280","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1038\/ng.440","article-title":"Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease","volume":"41","author":"Harold","year":"2009","journal-title":"Nature Genetics"},{"issue":"7","key":"10.1016\/bs.irn.2020.02.002_bb0285","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1001\/archneur.1990.00530070043010","article-title":"Longitudinal study of cerebral metabolic asymmetries and associated neuropsychological patterns in early dementia of the Alzheimer type","volume":"47","author":"Haxby","year":"1990","journal-title":"Archives of Neurology"},{"issue":"10","key":"10.1016\/bs.irn.2020.02.002_bb0290","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1021\/bi00862a001","article-title":"Estimation of the pentose cycle contribution to glucose metabolism in tissue in vivo","volume":"6","author":"Hostetler","year":"1967","journal-title":"Biochemistry"},{"issue":"3","key":"10.1016\/bs.irn.2020.02.002_bb0295","doi-asserted-by":"crossref","first-page":"E578","DOI":"10.1152\/ajpendo.00093.2009","article-title":"The Randle cycle revisited: A new head for an old hat","volume":"297","author":"Hue","year":"2009","journal-title":"American Journal of Physiology. Endocrinology and Metabolism"},{"issue":"9","key":"10.1016\/bs.irn.2020.02.002_bb0300","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.2337\/db11-0466","article-title":"Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor","volume":"60","author":"Johnson","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/bs.irn.2020.02.002_bb0305","doi-asserted-by":"crossref","first-page":"43701","DOI":"10.1038\/srep43701","article-title":"Apolipoprotein E4 and insulin resistance interact to impair cognition and alter the epigenome and metabolome","volume":"7","author":"Johnson","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/bs.irn.2020.02.002_bb0310","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1177\/0271678X17746186","article-title":"Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response","volume":"39","author":"Johnson","year":"2017","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"issue":"5","key":"10.1016\/bs.irn.2020.02.002_bb0315","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1177\/0271678X17746186","article-title":"Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response","volume":"39","author":"Johnson","year":"2019","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0320","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0891-5849(99)00232-4","article-title":"Differential oxidation of apolipoprotein E isoforms and interaction with phospholipids","volume":"28","author":"Jolivalt","year":"2000","journal-title":"Free Radical Biology & Medicine"},{"key":"10.1016\/bs.irn.2020.02.002_bb0325","doi-asserted-by":"crossref","first-page":"943162","DOI":"10.1155\/2014\/943162","article-title":"A comprehensive review on metabolic syndrome","volume":"2014","author":"Kaur","year":"2014","journal-title":"Cardiology Research and Practice"},{"issue":"2","key":"10.1016\/bs.irn.2020.02.002_bb0330","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3233\/JAD-150348","article-title":"Human ApoE isoforms differentially modulate glucose and amyloid metabolic pathways in female brain: Evidence of the mechanism of neuroprotection by ApoE2 and implications for Alzheimer's disease prevention and early intervention","volume":"48","author":"Keeney","year":"2015","journal-title":"Journal of Alzheimer's Disease"},{"issue":"4","key":"10.1016\/bs.irn.2020.02.002_bb0335","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1046\/j.1471-4159.2000.0741579.x","article-title":"Amyloid beta-peptide effects on synaptosomes from apolipoprotein E-deficient mice","volume":"74","author":"Keller","year":"2000","journal-title":"Journal of Neurochemistry"},{"issue":"6","key":"10.1016\/bs.irn.2020.02.002_bb0340","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1053\/gast.1996.v110.pm8964404","article-title":"Is the development of adenoma and carcinoma in proximal colon related to apolipoprotein E phenotype?","volume":"110","author":"Kervinen","year":"1996","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/bs.irn.2020.02.002_bb0345","doi-asserted-by":"crossref","first-page":"E313","DOI":"10.1188\/14.ONF.E313-E325","article-title":"Apolipoprotein E genotype and cognitive function in postmenopausal women with early-stage breast cancer","volume":"41","author":"Koleck","year":"2014","journal-title":"Oncology Nursing Forum"},{"issue":"3","key":"10.1016\/bs.irn.2020.02.002_bb0350","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.molcel.2015.06.017","article-title":"Acute activation of oxidative pentose phosphate pathway as first-line response to oxidative stress in human skin cells","volume":"59","author":"Kuehne","year":"2015","journal-title":"Molecular Cell"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0355","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1089\/rej.2012.1362","article-title":"Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations","volume":"16","author":"Kulminski","year":"2013","journal-title":"Rejuvenation Research"},{"issue":"6","key":"10.1016\/bs.irn.2020.02.002_bb0360","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/alzrt93","article-title":"Amyloid imaging in the differential diagnosis of dementia: Review and potential clinical applications","volume":"3","author":"Laforce","year":"2011","journal-title":"Alzheimer's Research & Therapy"},{"issue":"8","key":"10.1016\/bs.irn.2020.02.002_bb0365","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1021\/bi002312k","article-title":"Vulnerability of synaptosomes from apoE knock-out mice to structural and oxidative modifications induced by A beta(1-40): Implications for Alzheimer's disease","volume":"40","author":"Lauderback","year":"2001","journal-title":"Biochemistry"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0370","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0006-8993(01)03228-0","article-title":"Apolipoprotein E modulates Alzheimer's Abeta(1-42)-induced oxidative damage to synaptosomes in an allele-specific manner","volume":"924","author":"Lauderback","year":"2002","journal-title":"Brain Research"},{"issue":"4","key":"10.1016\/bs.irn.2020.02.002_bb0375","doi-asserted-by":"crossref","first-page":"C500","DOI":"10.1152\/ajpcell.00120.2016","article-title":"Triglyceride-rich lipoprotein lipolysis products increase blood-brain barrier transfer coefficient and induce astrocyte lipid droplets and cell stress","volume":"312","author":"Lee","year":"2017","journal-title":"American Journal of Physiology. Cell Physiology"},{"issue":"2","key":"10.1016\/bs.irn.2020.02.002_bb0380","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.trci.2015.07.001","article-title":"Marked gender differences in progression of mild cognitive impairment over 8 years","volume":"1","author":"Lin","year":"2015","journal-title":"Alzheimer's & dementia: Translational Research & Clinical Interventions"},{"key":"10.1016\/bs.irn.2020.02.002_bb0385","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.genom.1.1.507","article-title":"Apolipoprotein E: Far more than a lipid transport protein","volume":"1","author":"Mahley","year":"2000","journal-title":"Annual Review of Genomics and Human Genetics"},{"issue":"5","key":"10.1016\/bs.irn.2020.02.002_bb0390","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/00005072-199805000-00005","article-title":"Distribution of reducible 4-hydroxynonenal adduct immunoreactivity in Alzheimer disease is associated with APOE genotype","volume":"57","author":"Montine","year":"1998","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"issue":"4","key":"10.1016\/bs.irn.2020.02.002_bb0395","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.3233\/JAD-170148","article-title":"Effect of APOE epsilon4 genotype on metabolic biomarkers in aging and Alzheimer's disease","volume":"58","author":"Morris","year":"2017","journal-title":"Journal of Alzheimer's Disease"},{"issue":"5","key":"10.1016\/bs.irn.2020.02.002_bb0400","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.neurobiolaging.2006.12.008","article-title":"Hippocampal hypometabolism predicts cognitive decline from normal aging","volume":"29","author":"Mosconi","year":"2008","journal-title":"Neurobiology of Aging"},{"issue":"3","key":"10.1016\/bs.irn.2020.02.002_bb0405","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/00002093-199809000-00012","article-title":"Reduced levels of cholesterol, phospholipids, and fatty acids in cerebrospinal fluid of Alzheimer disease patients are not related to apolipoprotein E4","volume":"12","author":"Mulder","year":"1998","journal-title":"Alzheimer Disease and Associated Disorders"},{"issue":"9","key":"10.1016\/bs.irn.2020.02.002_bb0410","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.2337\/dc06-1136","article-title":"Impact of recent increase in incidence on future diabetes burden: U.S., 2005-2050","volume":"29","author":"Narayan","year":"2006","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0415","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/s41467-017-01444-0","article-title":"Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology","volume":"8","author":"Nuriel","year":"2017","journal-title":"Nature Communications"},{"key":"10.1016\/bs.irn.2020.02.002_bb0420","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1038\/srep03754","article-title":"Reduced phosphorylation of brain insulin receptor substrate and Akt proteins in apolipoprotein-E4 targeted replacement mice","volume":"4","author":"Ong","year":"2014","journal-title":"Scientific Reports"},{"key":"10.1016\/bs.irn.2020.02.002_bb0425","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2011.55","article-title":"Metabolome in progression to Alzheimer's disease","volume":"1","author":"Oresic","year":"2011","journal-title":"Translational Psychiatry"},{"issue":"5","key":"10.1016\/bs.irn.2020.02.002_bb0430","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1177\/026765919601100502","article-title":"Cerebral blood flow in the diabetic patient","volume":"11","author":"Pallas","year":"1996","journal-title":"Perfusion"},{"issue":"3\u20134","key":"10.1016\/bs.irn.2020.02.002_bb0435","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s007020050161","article-title":"The activity of the pentose phosphate pathway is increased in response to oxidative stress in Alzheimer's disease","volume":"106","author":"Palmer","year":"1999","journal-title":"Journal of Neural Transmission (Vienna)"},{"key":"10.1016\/bs.irn.2020.02.002_bb0440","doi-asserted-by":"crossref","first-page":"472459","DOI":"10.1155\/2014\/472459","article-title":"Fatty acids in energy metabolism of the central nervous system","volume":"2014","author":"Panov","year":"2014","journal-title":"BioMed Research International"},{"issue":"4","key":"10.1016\/bs.irn.2020.02.002_bb0445","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.2337\/diabetes.51.4.1256","article-title":"Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: The Honolulu-Asia Aging Study","volume":"51","author":"Peila","year":"2002","journal-title":"Diabetes"},{"issue":"Suppl","key":"10.1016\/bs.irn.2020.02.002_bb0450","doi-asserted-by":"crossref","first-page":"S178","DOI":"10.1194\/jlr.R800070-JLR200","article-title":"Apolipoprotein E knock-out and knock-in mice: Atherosclerosis, metabolic syndrome, and beyond","volume":"50","author":"Pendse","year":"2009","journal-title":"Journal of Lipid Research"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0455","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3233\/JAD-151205","article-title":"Altered energy metabolism pathways in the posterior cingulate in young adult apolipoprotein E varepsilon4 carriers","volume":"53","author":"Perkins","year":"2016","journal-title":"Journal of Alzheimer's Disease"},{"issue":"9","key":"10.1016\/bs.irn.2020.02.002_bb0460","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1002\/iub.1314","article-title":"Apolipoprotein E isoforms and lipoprotein metabolism","volume":"66","author":"Phillips","year":"2014","journal-title":"IUBMB Life"},{"issue":"5","key":"10.1016\/bs.irn.2020.02.002_bb0465","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1042\/BST20160094","article-title":"The Warburg effect: 80 years on","volume":"44","author":"Potter","year":"2016","journal-title":"Biochemical Society Transactions"},{"issue":"5","key":"10.1016\/bs.irn.2020.02.002_bb0470","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.neurobiolaging.2003.12.023","article-title":"ApoE genotype accounts for the vast majority of AD risk and AD pathology","volume":"25","author":"Raber","year":"2004","journal-title":"Neurobiology of Aging"},{"issue":"5\u20136","key":"10.1016\/bs.irn.2020.02.002_bb0475","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S0891-5849(99)00102-1","article-title":"Oxidative damage and protection by antioxidants in the frontal cortex of Alzheimer's disease is related to the apolipoprotein E genotype","volume":"27","author":"Ramassamy","year":"1999","journal-title":"Free Radical Biology & Medicine"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0480","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/nbdi.1999.0273","article-title":"Oxidative insults are associated with apolipoprotein E genotype in Alzheimer's disease brain","volume":"7","author":"Ramassamy","year":"2000","journal-title":"Neurobiology of Disease"},{"issue":"7285","key":"10.1016\/bs.irn.2020.02.002_bb0485","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(63)91500-9","article-title":"The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus","volume":"1","author":"Randle","year":"1963","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/bs.irn.2020.02.002_bb0490","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1073\/pnas.061509598","article-title":"Declining brain activity in cognitively normal apolipoprotein E epsilon 4 heterozygotes: A foundation for using positron emission tomography to efficiently test treatments to prevent Alzheimer's disease","volume":"98","author":"Reiman","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"12","key":"10.1016\/bs.irn.2020.02.002_bb0495","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1056\/NEJM199603213341202","article-title":"Preclinical evidence of Alzheimer's disease in persons homozygous for the epsilon 4 allele for apolipoprotein E","volume":"334","author":"Reiman","year":"1996","journal-title":"The New England Journal of Medicine"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0500","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1073\/pnas.2635903100","article-title":"Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia","volume":"101","author":"Reiman","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"10.1016\/bs.irn.2020.02.002_bb0505","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3233\/JAD-150307","article-title":"Central nervous system delivery of intranasal insulin: Mechanisms of uptake and effects on cognition","volume":"47","author":"Salameh","year":"2015","journal-title":"Journal of Alzheimer's Disease"},{"issue":"10","key":"10.1016\/bs.irn.2020.02.002_bb0510","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/jcbfm.2013.128","article-title":"Why does brain metabolism not favor burning of fatty acids to provide energy? Reflections on disadvantages of the use of free fatty acids as fuel for brain","volume":"33","author":"Schonfeld","year":"2013","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"issue":"3","key":"10.1016\/bs.irn.2020.02.002_bb0515","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00432-014-1773-5","article-title":"Alzheimer disease and cancer risk: A meta-analysis","volume":"141","author":"Shi","year":"2015","journal-title":"Journal of Cancer Research and Clinical Oncology"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0520","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0304-3835(00)00724-2","article-title":"Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men","volume":"164","author":"Shinomiya","year":"2001","journal-title":"Cancer Letters"},{"issue":"11","key":"10.1016\/bs.irn.2020.02.002_bb0525","doi-asserted-by":"crossref","first-page":"6037","DOI":"10.1073\/pnas.090106797","article-title":"Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease","volume":"97","author":"Small","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"12","key":"10.1016\/bs.irn.2020.02.002_bb0530","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1001\/jama.1995.03520360056039","article-title":"Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease","volume":"273","author":"Small","year":"1995","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/bs.irn.2020.02.002_bb0535","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1590\/S0100-879X2009000500001","article-title":"Association between apolipoprotein E genotype, serum lipids, and colorectal cancer in Brazilian individuals","volume":"42","author":"Souza","year":"2009","journal-title":"Brazilian Journal of Medical and Biological Research"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0540","first-page":"55","article-title":"CNS and fatty acid metabolism","volume":"16","author":"Spitzer","year":"1973","journal-title":"Physiologist"},{"issue":"2","key":"10.1016\/bs.irn.2020.02.002_bb0545","doi-asserted-by":"crossref","first-page":"e00078","DOI":"10.1042\/AN20120002","article-title":"Astroglial pentose phosphate pathway rates in response to high-glucose environments","volume":"4","author":"Takahashi","year":"2012","journal-title":"ASN Neuro"},{"issue":"4","key":"10.1016\/bs.irn.2020.02.002_bb0550","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1172\/JCI59903","article-title":"Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline","volume":"122","author":"Talbot","year":"2012","journal-title":"The Journal of Clinical Investigation"},{"issue":"Pt. 6","key":"10.1016\/bs.irn.2020.02.002_bb0555","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1529-8817.2005.00205.x","article-title":"The significant increase in cardiovascular disease risk in APOEepsilon4 carriers is evident only in men who smoke: Potential relationship between reduced antioxidant status and ApoE4","volume":"69","author":"Talmud","year":"2005","journal-title":"Annals of Human Genetics"},{"issue":"12","key":"10.1016\/bs.irn.2020.02.002_bb0560","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1212\/WNL.54.12.2319","article-title":"Apolipoprotein E allele-dependent antioxidant activity in brains with Alzheimer's disease","volume":"54","author":"Tamaoka","year":"2000","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/bs.irn.2020.02.002_bb0565","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0108605","article-title":"The apolipoprotein E polymorphism rs7412 associates with body fatness independently of plasma lipids in middle aged men","volume":"9","author":"Tejedor","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0570","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1001\/archneurol.2009.913","article-title":"APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging","volume":"67","author":"Thambisetty","year":"2010","journal-title":"Archives of Neurology"},{"issue":"7","key":"10.1016\/bs.irn.2020.02.002_bb0575","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0102477","article-title":"Apolipoprotein E polymorphism and colorectal neoplasm: Results from a meta-analysis","volume":"9","author":"Tian","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/bs.irn.2020.02.002_bb0580","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016991","article-title":"The epsilon3 and epsilon4 alleles of human APOE differentially affect tau phosphorylation in hyperinsulinemic and pioglitazone treated mice","volume":"6","author":"To","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/bs.irn.2020.02.002_bb0585","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.brainresbull.2016.06.005","article-title":"Oxidative stress, protein modification and Alzheimer disease","volume":"133","author":"Tramutola","year":"2017","journal-title":"Brain Research Bulletin"},{"issue":"12","key":"10.1016\/bs.irn.2020.02.002_bb0590","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1038\/ncb1807","article-title":"Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c","volume":"10","author":"Vaughn","year":"2008","journal-title":"Nature Cell Biology"},{"issue":"9","key":"10.1016\/bs.irn.2020.02.002_bb0595","doi-asserted-by":"crossref","first-page":"7332","DOI":"10.3390\/nu7095341","article-title":"Shared neuropathological characteristics of obesity, Type 2 diabetes and Alzheimer's disease: Impacts on cognitive decline","volume":"7","author":"Walker","year":"2015","journal-title":"Nutrients"},{"key":"10.1016\/bs.irn.2020.02.002_bb0600","first-page":"12","article-title":"Selective neuronal vulnerability to oxidative stress in the brain","volume":"2","author":"Wang","year":"2010","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"5","key":"10.1016\/bs.irn.2020.02.002_bb0605","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1042\/CS20020329","article-title":"Apolipoprotein E gene polymorphism and colorectal cancer: Gender-specific modulation of risk and prognosis","volume":"104","author":"Watson","year":"2003","journal-title":"Clinical Science (London, England)"},{"key":"10.1016\/bs.irn.2020.02.002_bb0610","doi-asserted-by":"crossref","first-page":"104742","DOI":"10.1016\/j.nbd.2020.104742","article-title":"APOE alters glucose flux through central carbon pathways in astrocytes","volume":"136","author":"Williams","year":"2019","journal-title":"Neurobiology of Disease"},{"issue":"6","key":"10.1016\/bs.irn.2020.02.002_bb0615","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/jnnp.73.6.672","article-title":"The apolipoprotein E epsilon 2 allele and decline in episodic memory","volume":"73","author":"Wilson","year":"2002","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"issue":"10","key":"10.1016\/bs.irn.2020.02.002_bb0620","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1161\/01.ATV.16.10.1250","article-title":"Apolipoprotein E alleles and risk of coronary disease. A meta-analysis","volume":"16","author":"Wilson","year":"1996","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"4","key":"10.1016\/bs.irn.2020.02.002_bb0625","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.neurobiolaging.2012.10.011","article-title":"APOE and neuroenergetics: An emerging paradigm in Alzheimer's disease","volume":"34","author":"Wolf","year":"2013","journal-title":"Neurobiology of Aging"},{"issue":"30","key":"10.1016\/bs.irn.2020.02.002_bb0630","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.1523\/JNEUROSCI.2262-17.2018","article-title":"Human ApoE isoforms differentially modulate brain glucose and ketone body metabolism: Implications for Alzheimer's disease risk reduction and early intervention","volume":"38","author":"Wu","year":"2018","journal-title":"The Journal of Neuroscience"},{"issue":"19","key":"10.1016\/bs.irn.2020.02.002_bb0635","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1523\/JNEUROSCI.5476-05.2006","article-title":"Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus","volume":"26","author":"Xu","year":"2006","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0640","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13195-017-0250-1","article-title":"DHA brain uptake and APOE4 status: A PET study with [1-(11)C]-DHA","volume":"9","author":"Yassine","year":"2017","journal-title":"Alzheimer's Research & Therapy"},{"key":"10.1016\/bs.irn.2020.02.002_bb0645","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s13195-016-0194-x","article-title":"The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer's disease","volume":"8","author":"Yassine","year":"2016","journal-title":"Alzheimer's Research & Therapy"},{"issue":"16","key":"10.1016\/bs.irn.2020.02.002_bb0650","doi-asserted-by":"crossref","first-page":"10583","DOI":"10.1016\/S0021-9258(18)99263-X","article-title":"Apolipoprotein E gene expression in mouse 3T3-L1 adipocytes and human adipose tissue and its regulation by differentiation and lipid content","volume":"266","author":"Zechner","year":"1991","journal-title":"The Journal of Biological Chemistry"},{"issue":"5","key":"10.1016\/bs.irn.2020.02.002_bb0655","doi-asserted-by":"crossref","first-page":"463","DOI":"10.4103\/1673-5374.130060","article-title":"Apolipoprotein E mimetic peptide protects against diffuse brain injury","volume":"9","author":"Zhao","year":"2014","journal-title":"Neural Regeneration Research"},{"issue":"1","key":"10.1016\/bs.irn.2020.02.002_bb0660","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neuron.2017.09.003","article-title":"Apolipoprotein E4 impairs neuronal insulin signaling by trapping insulin receptor in the endosomes","volume":"96","author":"Zhao","year":"2017","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/bs.irn.2020.02.002_bb0665","first-page":"161","article-title":"Association of serum lipids and apolipoprotein E gene polymorphism with the risk of colorectal adenomas","volume":"27","author":"Zhongyin","year":"2006","journal-title":"Saudi Medical Journal"}],"container-title":["International Review of Neurobiology","Metabolic and Bioenergetic Drivers of Neurodegenerative Disease: Neurodegenerative Disease Research and Commonalities with Metabolic Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774220300118?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774220300118?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T21:13:05Z","timestamp":1758748385000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0074774220300118"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9780128200766"],"references-count":132,"URL":"https:\/\/doi.org\/10.1016\/bs.irn.2020.02.002","relation":{},"ISSN":["0074-7742"],"issn-type":[{"value":"0074-7742","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]}}}