{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T04:52:36Z","timestamp":1788324756425,"version":"build-2803163510"},"reference-count":197,"publisher":"Elsevier","isbn-type":[{"value":"9780443294686","type":"print"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/bs.irn.2023.06.006","type":"book-chapter","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T21:00:40Z","timestamp":1695762040000},"page":"145-185","source":"Crossref","is-referenced-by-count":2,"title":["Co-administration of dl-3-n-butylphthalide and neprilysin is neuroprotective in Alzheimer disease associated with mild traumatic brain injury"],"prefix":"10.1016","author":[{"given":"Zhenguo G.","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aruna","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianyuan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafin F.","family":"Muresanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z. Ryan","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Vicente","family":"Lafuente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca D.","family":"Buzoianu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala","family":"Nozari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Manzhulo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Wiklund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Shanker","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.irn.2023.06.006_bib1","doi-asserted-by":"crossref","first-page":"5012341","DOI":"10.1155\/2016\/5012341","article-title":"A review of recent advances in neuroprotective potential of 3-N-butylphthalide and its derivatives","volume":"2016","author":"Abdoulaye","year":"2016","journal-title":"BioMed Research International"},{"issue":"9","key":"10.1016\/bs.irn.2023.06.006_bib2","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.jalz.2018.05.004","article-title":"Cerebrospinal fluid tau, A\u03b2, and sTREM2 in Former National Football League Players: Modeling the relationship between repetitive head impacts, microglial activation, and neurodegeneration","volume":"14","author":"Alosco","year":"2018","journal-title":"Alzheimer\u2019s & Dementia: The Journal of the Alzheimer\u2019s Association"},{"issue":"2","key":"10.1016\/bs.irn.2023.06.006_bib3","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.pmr.2016.12.008","article-title":"Unique aspects of traumatic brain injury in military and veteran populations","volume":"28","author":"Armistead-Jehle","year":"2017","journal-title":"Physical Medicine and Rehabilitation Clinics of North America"},{"issue":"Pt B","key":"10.1016\/bs.irn.2023.06.006_bib4","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.neuropharm.2015.04.029","article-title":"Myelin and oligodendrocyte lineage cells in white matter pathology and plasticity after traumatic brain injury","volume":"110","author":"Armstrong","year":"2016","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/bs.irn.2023.06.006_bib5","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1134\/S0006297921060067","article-title":"Effect of global brain ischemia on amyloid precursor protein metabolism and expression of amyloid-degrading enzymes in rat cortex: Role in pathogenesis of Alzheimer\u2019s disease","volume":"86","author":"Babusikova","year":"2021","journal-title":"Biochemistry. Biokhimiia"},{"issue":"8","key":"10.1016\/bs.irn.2023.06.006_bib6","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1080\/02699052.2018.1479042","article-title":"Dissociation of cerebrospinal fluid amyloid-\u03b2 and tau levels in patients with prolonged posttraumatic disorders of consciousness","volume":"32","author":"Bagnato","year":"2018","journal-title":"Brain Injury: [BI]"},{"key":"10.1016\/bs.irn.2023.06.006_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101619","article-title":"Oxidative stress: The core pathogenesis and mechanism of Alzheimer\u2019s disease","volume":"77","author":"Bai","year":"2022","journal-title":"Ageing Research Reviews"},{"issue":"16","key":"10.1016\/bs.irn.2023.06.006_bib8","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1089\/neu.2020.7566","article-title":"Cerebral blood flow predicts recovery in children with persistent post-concussion symptoms after mild traumatic brain injury","volume":"38","author":"Barlow","year":"2021","journal-title":"Journal of Neurotrauma"},{"issue":"5\u20136","key":"10.1016\/bs.irn.2023.06.006_bib9","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.mam.2012.03.008","article-title":"Brain water channel proteins in health and disease","volume":"33","author":"Benga","year":"2012","journal-title":"Molecular Aspects of Medicine"},{"issue":"7","key":"10.1016\/bs.irn.2023.06.006_bib10","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1177\/0271678X20982383","article-title":"Causes and consequences of baseline cerebral blood flow reductions in Alzheimer\u2019s disease","volume":"41","author":"Bracko","year":"2021","journal-title":"Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/bs.irn.2023.06.006_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2023.105509","article-title":"Oxidative stress: A target to treat Alzheimer\u2019s disease and stroke","volume":"165","author":"Briyal","year":"2023","journal-title":"Neurochemistry International"},{"issue":"2","key":"10.1016\/bs.irn.2023.06.006_bib12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1080\/02699052.2018.1540798","article-title":"Cerebral blood flow in children and adolescents several years after concussion","volume":"33","author":"Brooks","year":"2019","journal-title":"Brain Injury: [BI]"},{"issue":"6","key":"10.1016\/bs.irn.2023.06.006_bib13","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jalz.2016.02.010","article-title":"Neuroinflammation in Alzheimer\u2019s disease: Current evidence and future directions","volume":"12","author":"Calsolaro","year":"2016","journal-title":"Alzheimer\u2019s & Dementia: The Journal of the Alzheimer\u2019s Association"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/jramc-2015-000600","article-title":"A systematic review of military head injuries","volume":"163","author":"Carr","year":"2017","journal-title":"Journal of the Royal Army Medical Corps"},{"issue":"14","key":"10.1016\/bs.irn.2023.06.006_bib15","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1016\/j.neuron.2021.05.012","article-title":"Enhancing myelin renewal reverses cognitive dysfunction in a murine model of Alzheimer\u2019s disease","volume":"109","author":"Chen","year":"2021","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/bs.irn.2023.06.006_bib16","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1097\/CM9.0000000000000289","article-title":"Application and prospects of butylphthalide for the treatment of neurologic diseases","volume":"132","author":"Chen","year":"2019","journal-title":"Chinese Medical Journal (Engl)"},{"issue":"2","key":"10.1016\/bs.irn.2023.06.006_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s12264-013-1423-y","article-title":"Oxidative stress in Alzheimer\u2019s disease","volume":"30","author":"Chen","year":"2014","journal-title":"Neuroscience Bulletin"},{"issue":"8","key":"10.1016\/bs.irn.2023.06.006_bib18","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.jacc.2019.10.062","article-title":"Alzheimer\u2019s disease and vascular aging: JACC focus seminar","volume":"75","author":"Cortes-Canteli","year":"2020","journal-title":"Journal of the American College of Cardiology"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib19","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/jnc.15499","article-title":"Synaptophysin-dependent synaptobrevin-2 trafficking at the presynapse-Mechanism and function","volume":"159","author":"Cousin","year":"2021","journal-title":"Journal of Neurochemistry"},{"issue":"11","key":"10.1016\/bs.irn.2023.06.006_bib20","doi-asserted-by":"crossref","first-page":"972","DOI":"10.2174\/1567205017666201130092427","article-title":"The association between TNF-alpha, IL-1 alpha and IL-10 with Alzheimer\u2019s disease","volume":"17","author":"Culjak","year":"2020","journal-title":"Current Alzheimer Research"},{"issue":"4","key":"10.1016\/bs.irn.2023.06.006_bib21","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.3233\/JAD-201378","article-title":"Sleep deprivation, a link between post-traumatic stress disorder and Alzheimer\u2019s disease","volume":"79","author":"Delic","year":"2021","journal-title":"Journal of Alzheimer\u2019s Disease: JAD"},{"key":"10.1016\/bs.irn.2023.06.006_bib22","first-page":"554","article-title":"Ambient temperature and development of traumatic brain oedema in anaesthetized animals","volume":"77","author":"Dey","year":"1983","journal-title":"The Indian Journal of Medical Research"},{"issue":"3","key":"10.1016\/bs.irn.2023.06.006_bib23","first-page":"177","article-title":"Influence of ambient temperature and drug treatments on brain oedema induced by impact injury on skull in rats","volume":"28","author":"Dey","year":"1984","journal-title":"Indian Journal of Physiology and Pharmacology"},{"key":"10.1016\/bs.irn.2023.06.006_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.146924","article-title":"Impaired cerebral blood flow regulation in chronic traumatic brain injury","volume":"1743","author":"Ding","year":"2020","journal-title":"Brain Research"},{"issue":"11","key":"10.1016\/bs.irn.2023.06.006_bib25","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1038\/s41380-022-01711-7","article-title":"A novel circular RNA, circIgfbp2, links neural plasticity and anxiety through targeting mitochondrial dysfunction and oxidative stress-induced synapse dysfunction after traumatic brain injury","volume":"27","author":"Du","year":"2022","journal-title":"Molecular Psychiatry"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1152\/ajplegacy.1949.157.1.122","article-title":"Measurement of experimentally induced brain swelling and shrinkage","volume":"157","author":"Elliott","year":"1949","journal-title":"The American Journal of Physiology"},{"issue":"5","key":"10.1016\/bs.irn.2023.06.006_bib27","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3171\/jns.1977.47.5.0699","article-title":"Compartmental analysis of regional cerebral blood flow in patients with acute severe head injuries","volume":"47","author":"Enevoldsen","year":"1977","journal-title":"Journal of Neurosurgery"},{"issue":"9","key":"10.1016\/bs.irn.2023.06.006_bib28","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1007\/s00702-019-01988-z","article-title":"Stress and Alzheimer\u2019s disease","volume":"126","author":"Escher","year":"2019","journal-title":"Journal of Neural Transmission (Vienna)"},{"issue":"5","key":"10.1016\/bs.irn.2023.06.006_bib29","doi-asserted-by":"crossref","first-page":"508","DOI":"10.2174\/1570159X15666170720095240","article-title":"Microglia and astrocytes in Alzheimer\u2019s disease: Implications for therapy","volume":"16","author":"Fakhoury","year":"2018","journal-title":"Current Neuropharmacology"},{"key":"10.1016\/bs.irn.2023.06.006_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2020.147046","article-title":"Dl-3-n-butylphthalide attenuates hypoxic-ischemic brain injury through inhibiting endoplasmic reticulum stress-induced cell apoptosis and alleviating blood-brain barrier disruption in newborn rats","volume":"1747","author":"Fang","year":"2020","journal-title":"Brain Research"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib31","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s12035-017-0746-5","article-title":"TiO2-nanowired delivery of DL-3-n-butylphthalide (DL-NBP) attenuates blood-brain barrier disruption, brain edema formation, and neuronal damages following concussive head injury","volume":"55","author":"Feng","year":"2018","journal-title":"Molecular Neurobiology"},{"issue":"4","key":"10.1016\/bs.irn.2023.06.006_bib32","first-page":"341","article-title":"Cytokines, inflammation, and brain injury: Role of tumor necrosis factor-alpha","volume":"6","author":"Feuerstein","year":"1994","journal-title":"Cerebrovascular and Brain Metabolism Reviews"},{"key":"10.1016\/bs.irn.2023.06.006_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113923","article-title":"Preclinical investigation of Pegylated arginase 1 as a treatment for retina and brain injury","volume":"348","author":"Fouda","year":"2022","journal-title":"Experimental Neurology"},{"key":"10.1016\/bs.irn.2023.06.006_bib34","article-title":"Synaptophysin is a selective marker for axons in human cutaneous end organ complexes","volume":"243","author":"Garc\u00eda-Mesa","year":"2022","journal-title":"Annals of Anatomy = Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft"},{"issue":"20","key":"10.1016\/bs.irn.2023.06.006_bib35","doi-asserted-by":"crossref","first-page":"e1771","DOI":"10.1212\/WNL.0000000000005522","article-title":"Mild TBI and risk of Parkinson disease: A chronic effects of neurotrauma consortium study","volume":"90","author":"Gardner","year":"2018","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/bs.irn.2023.06.006_bib36","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1093\/gerona\/glw341","article-title":"Remote traumatic brain injury is associated with motor dysfunction in older military veterans","volume":"72","author":"Gardner","year":"2017","journal-title":"The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"issue":"Pt B","key":"10.1016\/bs.irn.2023.06.006_bib37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.mcn.2015.03.001","article-title":"Epidemiology of mild traumatic brain injury and neurodegenerative disease","volume":"66","author":"Gardner","year":"2015","journal-title":"Molecular and Cellular Neurosciences"},{"issue":"4","key":"10.1016\/bs.irn.2023.06.006_bib38","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.3233\/JAD-215479","article-title":"Alzheimer\u2019s disease: A decreased cerebral blood flow to critical intraneuronal elements is the cause","volume":"85","author":"Goldsmith","year":"2022","journal-title":"Journal of Alzheimer\u2019s Disease: JAD"},{"key":"10.1016\/bs.irn.2023.06.006_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101529","article-title":"Deregulated mitochondrial microRNAs in Alzheimer\u2019s disease: Focus on synapse and mitochondria","volume":"73","author":"Gowda","year":"2022","journal-title":"Ageing Research Reviews"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib40","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000524797","article-title":"Regional cerebral blood flow changes in healthy ageing and Alzheimer\u2019s disease: A narrative review","volume":"52","author":"Graff","year":"2023","journal-title":"Cerebrovascular Diseases (Basel, Switzerland)"},{"issue":"11","key":"10.1016\/bs.irn.2023.06.006_bib41","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1136\/jnnp-2017-317557","article-title":"Understanding neurodegeneration after traumatic brain injury: From mechanisms to clinical trials in dementia","volume":"90","author":"Graham","year":"2019","journal-title":"Journal of Neurology, Neurosurgery, and Psychiatry"},{"key":"10.1016\/bs.irn.2023.06.006_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577315","article-title":"Neuroinflammation drives APOE genotype-dependent differential expression of neprilysin","volume":"346","author":"Graykowski","year":"2020","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/bs.irn.2023.06.006_bib43","doi-asserted-by":"crossref","first-page":"894","DOI":"10.3389\/fnins.2020.00894","article-title":"The bidirectional relationship between sleep and inflammation links traumatic brain injury and Alzheimer\u2019s disease","volume":"14","author":"Green","year":"2020","journal-title":"Frontiers in Neuroscience"},{"key":"10.1016\/bs.irn.2023.06.006_bib44","unstructured":"National Research Council (US); Committee for the Update of the Guide for the Care and Use of Laboratory Animals. (2011). Guide for the care and use of laboratory animals (8th ed.). Washington (DC): National Academies Press (US). The National Academies Collection: Reports funded by National Institutes of Health. Bookshelf ID: NBK54050. https:\/\/doi.org\/10.17226\/12910; \u3008https:\/\/nap.nationalacademies.org\/catalog\/12910\/guide-for-the-care-and-use-of-laboratory-animals-eighth\u3009."},{"issue":"1\u20132","key":"10.1016\/bs.irn.2023.06.006_bib45","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jns.2014.07.064","article-title":"Meta-analysis of the association between two neprilysin gene polymorphisms and Alzheimer\u2019s disease","volume":"346","author":"Guo","year":"2014","journal-title":"Journal of the Neurological Sciences"},{"issue":"4","key":"10.1016\/bs.irn.2023.06.006_bib46","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/fcp.12767","article-title":"Oxidative stress and mitochondrial dysfunction following traumatic brain injury: From mechanistic view to targeted therapeutic opportunities","volume":"36","author":"Hakiminia","year":"2022","journal-title":"Fundamental & Clinical Pharmacology"},{"key":"10.1016\/bs.irn.2023.06.006_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2022.106164","article-title":"DL-3-n-butylphthalide prevents oxidative stress and atherosclerosis by targeting Keap-1 and inhibiting Keap-1\/Nrf-2 interaction","volume":"172","author":"Han","year":"2022","journal-title":"European Journal of Pharmaceutical Sciences: Official Journal of the European Federation for Pharmaceutical Sciences"},{"issue":"2","key":"10.1016\/bs.irn.2023.06.006_bib48","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.201709069","article-title":"Microglia in Alzheimer\u2019s disease","volume":"217","author":"Hansen","year":"2018","journal-title":"The Journal of Cell Biology"},{"issue":"3","key":"10.1016\/bs.irn.2023.06.006_bib49","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s11682-015-9399-z","article-title":"Traumatic brain injury in the US military: Epidemiology and key clinical and research programs","volume":"9","author":"Helmick","year":"2015","journal-title":"Brain Imaging and Behavior"},{"key":"10.1016\/bs.irn.2023.06.006_bib50","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.3389\/fneur.2019.01238","article-title":"Neuronal membrane disruption occurs late following diffuse brain trauma in rats and involves a subpopulation of NeuN negative cortical neurons","volume":"10","author":"Hernandez","year":"2019","journal-title":"Frontiers in Neurology"},{"key":"10.1016\/bs.irn.2023.06.006_bib51","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neurobiolaging.2021.07.014","article-title":"Emerging roles of oxidative stress in brain aging and Alzheimer\u2019s disease","volume":"107","author":"Ionescu-Tucker","year":"2021","journal-title":"Neurobiology of Aging"},{"issue":"2\u20134","key":"10.1016\/bs.irn.2023.06.006_bib52","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/BF01407455","article-title":"Brain swelling and brain oedema in acute head injury","volume":"79","author":"Ito","year":"1986","journal-title":"Acta Neurochirurgica"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib53","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1093\/brain\/awaa321","article-title":"The synapse in traumatic brain injury","volume":"144","author":"Jamjoom","year":"2021","journal-title":"Brain"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib54","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s40478-021-01264-w","article-title":"TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer\u2019s disease hippocampus","volume":"9","author":"Jayaraman","year":"2021","journal-title":"Acta Neuropathol Commun"},{"issue":"9","key":"10.1016\/bs.irn.2023.06.006_bib55","doi-asserted-by":"crossref","first-page":"613","DOI":"10.14348\/molcells.2017.0096","article-title":"Molecular and cellular basis of neurodegeneration in Alzheimer\u2019s disease","volume":"40","author":"Jeong","year":"2017","journal-title":"Molecules and Cells"},{"issue":"4","key":"10.1016\/bs.irn.2023.06.006_bib56","doi-asserted-by":"crossref","first-page":"891","DOI":"10.3233\/JAD-150379","article-title":"Impact of insulin degrading enzyme and neprilysin in Alzheimer\u2019s disease biology: Characterization of putative cognates for therapeutic applications","volume":"48","author":"Jha","year":"2015","journal-title":"Journal of Alzheimer\u2019s Disease: JAD"},{"key":"10.1016\/bs.irn.2023.06.006_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101208","article-title":"Synaptic basis of Alzheimer\u2019s disease: Focus on synaptic amyloid beta, P-tau and mitochondria","volume":"65","author":"John","year":"2021","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/bs.irn.2023.06.006_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2022.08.014","article-title":"Inflammasome activation in traumatic brain injury and Alzheimer\u2019s disease","volume":"254","author":"Johnson","year":"2023","journal-title":"Translational Research: The Journal of Laboratory and Clinical Medicine"},{"issue":"8","key":"10.1016\/bs.irn.2023.06.006_bib59","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1089\/neu.2008.0843","article-title":"A neprilysin polymorphism and amyloid-beta plaques after traumatic brain injury","volume":"26","author":"Johnson","year":"2009","journal-title":"Journal of Neurotrauma"},{"key":"10.1016\/bs.irn.2023.06.006_bib60","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.expneurol.2012.01.013","article-title":"Axonal pathology in traumatic brain injury","volume":"246","author":"Johnson","year":"2013","journal-title":"Experimental Neurology"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib61","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s40478-021-01220-8","article-title":"Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: Characterization of a novel model and systematic review of the literature","volume":"9","author":"Kahriman","year":"2021","journal-title":"Acta Neuropathologica Communications"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib62","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1007\/s12035-014-9053-6","article-title":"Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer\u2019s disease: Understanding the therapeutics strategies","volume":"53","author":"Kamat","year":"2016","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/bs.irn.2023.06.006_bib63","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.wneu.2022.07.062","article-title":"Outcomes following penetrating brain injuries in military settings: A systematic review and meta-analysis","volume":"166","author":"Karras","year":"2022","journal-title":"World Neurosurgery"},{"issue":"4","key":"10.1016\/bs.irn.2023.06.006_bib64","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/bph.13125","article-title":"The contribution of astrocytes and microglia to traumatic brain injury","volume":"173","author":"Karve","year":"2016","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/bs.irn.2023.06.006_bib65","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1891\/0739-6686.33.13","article-title":"Chapter 2 traumatic brain injury research in military populations","volume":"33","author":"Kasper","year":"2015","journal-title":"Annual Review of Nursing Research"},{"key":"10.1016\/bs.irn.2023.06.006_bib66","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3389\/fnins.2017.00703","article-title":"Mast cell activation in brain injury, stress, and post-traumatic stress disorder and Alzheimer\u2019s disease pathogenesis","volume":"11","author":"Kempuraj","year":"2017","journal-title":"Frontiers in Neuroscience"},{"issue":"9","key":"10.1016\/bs.irn.2023.06.006_bib67","doi-asserted-by":"crossref","first-page":"689","DOI":"10.2174\/1871527317666180627120501","article-title":"Oxidative stress: Major threat in traumatic brain injury","volume":"17","author":"Khatri","year":"2018","journal-title":"CNS & Neurological Disorders Drug Targets"},{"issue":"7","key":"10.1016\/bs.irn.2023.06.006_bib68","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nrn.2017.48","article-title":"Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease","volume":"18","author":"Kisler","year":"2017","journal-title":"Nature Reviews. Neuroscience"},{"key":"10.1016\/bs.irn.2023.06.006_bib69","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/bs.irn.2019.06.010","article-title":"Leakage of the blood-brain barrier followed by vasogenic edema as the ultimate cause of death induced by acute methamphetamine overdose","volume":"146","author":"Kiyatkin","year":"2019","journal-title":"International Review of Neurobiology"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib70","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/jnc.14797","article-title":"Synaptophysin sustains presynaptic performance by preserving vesicular synaptobrevin-II levels","volume":"151","author":"Kokotos","year":"2019","journal-title":"Journal of Neurochemistry"},{"issue":"6","key":"10.1016\/bs.irn.2023.06.006_bib71","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00401-020-02215-w","article-title":"Cerebral blood flow decrease as an early pathological mechanism in Alzheimer\u2019s disease","volume":"140","author":"Korte","year":"2020","journal-title":"Acta Neuropathologica"},{"key":"10.1016\/bs.irn.2023.06.006_bib72","article-title":"The role of diphenhydramine HCl on tumor necrosis factor-\u03b1 levels in wistar rats with traumatic brain injury: An in vivo study","volume":"81","author":"Kurniawan","year":"2022","journal-title":"Annals of Medicine and Surgery (Lond)"},{"issue":"3","key":"10.1016\/bs.irn.2023.06.006_bib73","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: Where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nature Reviews Neurology"},{"key":"10.1016\/bs.irn.2023.06.006_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110124","article-title":"Trait anxiety, a personality risk factor associated with Alzheimer\u2019s disease","volume":"105","author":"Li","year":"2021","journal-title":"Progress in Neuro-psychopharmacology & Biological Psychiatry"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib75","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20171611","article-title":"The antioxidant xanthorrhizol prevents amyloid-\u03b2-induced oxidative modification and inactivation of neprilysin","volume":"38","author":"Lim","year":"2018","journal-title":"Bioscience Reports"},{"issue":"3 Suppl","key":"10.1016\/bs.irn.2023.06.006_bib76","first-page":"S188","article-title":"Imaging chronic traumatic brain injury as a risk factor for neurodegeneration","volume":"10","author":"Little","year":"2014","journal-title":"Alzheimer\u2019s & Dementia: The Journal of the Alzheimer\u2019s Association"},{"issue":"7","key":"10.1016\/bs.irn.2023.06.006_bib77","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1111\/ene.15332","article-title":"Genetically predicted frailty index and risk of stroke and Alzheimer\u2019s disease","volume":"29","author":"Liu","year":"2022","journal-title":"European Journal of Neurology: The Official Journal of the European Federation of Neurological Societies"},{"issue":"2","key":"10.1016\/bs.irn.2023.06.006_bib78","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1590\/1980-5764-dn-2021-0029","article-title":"Changes in personality traits in patients with Alzheimer\u2019s disease","volume":"16","author":"Lopes","year":"2022","journal-title":"Dementia & Neuropsychologia"},{"issue":"4","key":"10.1016\/bs.irn.2023.06.006_bib79","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.3233\/JAD-201242","article-title":"Obesity and white matter neuroinflammation related edema in Alzheimer\u2019s disease dementia biomarker negative cognitively normal individuals","volume":"79","author":"Ly","year":"2021","journal-title":"Journal of Alzheimer\u2019s Disease: JAD"},{"key":"10.1016\/bs.irn.2023.06.006_bib80","doi-asserted-by":"crossref","DOI":"10.1016\/j.conb.2022.102575","article-title":"How neurons die in Alzheimer\u2019s disease: Implications for neuroinflammation","volume":"75","author":"Mangalmurti","year":"2022","journal-title":"Current Opinion in Neurobiology"},{"issue":"10","key":"10.1016\/bs.irn.2023.06.006_bib81","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1111\/sms.14018","article-title":"Impaired cerebral blood flow regulation and cognition in male football players","volume":"31","author":"Marley","year":"2021","journal-title":"Scandinavian Journal of Medicine & Science in Sports"},{"issue":"3","key":"10.1016\/bs.irn.2023.06.006_bib82","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/bpa.12248","article-title":"The neuropathology of chronic traumatic encephalopathy","volume":"25","author":"McKee","year":"2015","journal-title":"Brain Pathology (Zurich, Switzerland)"},{"issue":"21","key":"10.1016\/bs.irn.2023.06.006_bib83","doi-asserted-by":"crossref","first-page":"12990","DOI":"10.3390\/ijms232112990","article-title":"Microglia and Alzheimer\u2019s disease","volume":"23","author":"Merighi","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib84","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0022-510X(89)90048-8","article-title":"Role of histamine in traumatic brain edema. An experimental study in the rat","volume":"90","author":"Mohanty","year":"1989","journal-title":"Journal of the Neurological Sciences"},{"issue":"6","key":"10.1016\/bs.irn.2023.06.006_bib85","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1080\/01616412.2021.2022921","article-title":"Pathogenic cis p-tau levels in CSF reflects severity of traumatic brain injury","volume":"44","author":"Mohsenian Sisakht","year":"2022","journal-title":"Neurological Research"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib86","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1186\/s12974-020-02028-4","article-title":"Neuroprotective epi-drugs quench the inflammatory response and microglial\/macrophage activation in a mouse model of permanent brain ischemia","volume":"17","author":"Mota","year":"2020","journal-title":"Journal of Neuroinflammation"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib87","doi-asserted-by":"crossref","first-page":"32","DOI":"10.2174\/1874609809666161111101111","article-title":"Role of ageing and oxidative stress in regulation of amyloid-degrading enzymes and development of neurodegeneration","volume":"10","author":"Nalivaeva","year":"2017","journal-title":"Current Aging Science"},{"issue":"18","key":"10.1016\/bs.irn.2023.06.006_bib88","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1111\/bph.14593","article-title":"Targeting amyloid clearance in Alzheimer\u2019s disease as a therapeutic strategy","volume":"176","author":"Nalivaeva","year":"2019","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/bs.irn.2023.06.006_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.mad.2020.111363","article-title":"Neprilysin expression and functions in development, ageing and disease","volume":"192","author":"Nalivaeva","year":"2020","journal-title":"Mechanisms of Ageing and Development"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib90","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s40478-018-0515-3","article-title":"White matter changes in Alzheimer\u2019s disease: A focus on myelin and oligodendrocytes","volume":"6","author":"Nasrabady","year":"2018","journal-title":"Acta Neuropathol Commun"},{"issue":"2","key":"10.1016\/bs.irn.2023.06.006_bib91","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3171\/jns.1977.47.2.0262","article-title":"Experimental head injury in the rat. Part 3: Cerebral blood flow and oxygen consumption after concussive impact acceleration","volume":"47","author":"Nilsson","year":"1977","journal-title":"Journal of Neurosurgery"},{"key":"10.1016\/bs.irn.2023.06.006_bib92","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/bs.pbr.2019.03.008","article-title":"Nanowired delivery of DL-3-n-butylphthalide induces superior neuroprotection in concussive head injury","volume":"245","author":"Niu","year":"2019","journal-title":"Progress in Brain Research"},{"key":"10.1016\/bs.irn.2023.06.006_bib93","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/bs.pbr.2020.09.011","article-title":"Co-administration of TiO2-nanowired dl-3-n-butylphthalide (dl-NBP) and mesenchymal stem cells enhanced neuroprotection in Parkinson\u2019s disease exacerbated by concussive head injury","volume":"258","author":"Niu","year":"2020","journal-title":"Progress in Brain Research"},{"issue":"11","key":"10.1016\/bs.irn.2023.06.006_bib94","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1089\/neu.2020.7254","article-title":"Behavioral and myelin-related abnormalities after blast-induced mild traumatic brain injury in mice","volume":"38","author":"Nonaka","year":"2021","journal-title":"Journal of Neurotrauma"},{"issue":"2","key":"10.1016\/bs.irn.2023.06.006_bib95","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.13034","article-title":"Axonal injury following mild traumatic brain injury is exacerbated by repetitive insult and is linked to the delayed attenuation of NeuN expression without concomitant neuronal death in the mouse","volume":"32","author":"Ogino","year":"2022","journal-title":"Brain Pathology (Zurich, Switzerland)"},{"key":"10.1016\/bs.irn.2023.06.006_bib96","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/B978-0-12-386986-9.00005-3","article-title":"Quercetin in hypoxia-induced oxidative stress: novel target for neuroprotection","volume":"102","author":"Pandey","year":"2012","journal-title":"International Review of Neurobiology"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib97","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/s12035-017-0743-8","article-title":"Histamine H3 inverse agonist BF 2649 or antagonist with partial H4 agonist activity clobenpropit reduces amyloid beta peptide-induced brain pathology in Alzheimer\u2019s disease","volume":"55","author":"Patnaik","year":"2018","journal-title":"Molecular Neurobiology"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib98","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1093\/brain\/awab281","article-title":"Astrocyte-neuron interplay is critical for Alzheimer\u2019s disease pathogenesis and is rescued by TRPA1 channel blockade","volume":"145","author":"Paumier","year":"2022","journal-title":"Brain"},{"issue":"7","key":"10.1016\/bs.irn.2023.06.006_bib99","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1038\/s41380-022-01565-z","article-title":"The synapse as a treatment avenue for Alzheimer\u2019s disease","volume":"27","author":"Peng","year":"2022","journal-title":"Molecular Psychiatry"},{"issue":"8","key":"10.1016\/bs.irn.2023.06.006_bib100","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1089\/ars.2020.8134","article-title":"Preventive and therapeutic strategies in Alzheimer\u2019s disease: Focus on oxidative stress, redox metals, and ferroptosis","volume":"34","author":"Plascencia-Villa","year":"2021","journal-title":"Antioxidants & Redox Signaling"},{"issue":"8","key":"10.1016\/bs.irn.2023.06.006_bib101","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1212\/WNL.55.8.1158","article-title":"Documented head injury in early adulthood and risk of Alzheimer\u2019s disease and other dementias","volume":"55","author":"Plassman","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/bs.irn.2023.06.006_bib102","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108902","article-title":"Intervention of neuroinflammation in the traumatic brain injury trajectory: In vivo and clinical approaches","volume":"108","author":"Prabhakar","year":"2022","journal-title":"International Immunopharmacology"},{"issue":"18","key":"10.1016\/bs.irn.2023.06.006_bib103","doi-asserted-by":"crossref","first-page":"8797","DOI":"10.7150\/thno.61601","article-title":"Activating AhR alleviates cognitive deficits of Alzheimer\u2019s disease model mice by upregulating endogenous A\u03b2 catabolic enzyme Neprilysin","volume":"11","author":"Qian","year":"2021","journal-title":"Theranostics"},{"issue":"3","key":"10.1016\/bs.irn.2023.06.006_bib104","doi-asserted-by":"crossref","first-page":"669","DOI":"10.3233\/JAD-150774","article-title":"Chronic sleep deprivation exacerbates learning-Memory disability and Alzheimer\u2019s disease-like pathologies in A\u03b2PP(swe)\/PS1(\u0394E9) mice","volume":"50","author":"Qiu","year":"2016","journal-title":"Journal of Alzheimer\u2019s Disease: JAD"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib105","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13024-021-00488-7","article-title":"Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer\u2019s disease-like neuroinflammation and cognitive impairment","volume":"16","author":"Qiu","year":"2021","journal-title":"Molecular Neurodegeneration"},{"issue":"3","key":"10.1016\/bs.irn.2023.06.006_bib106","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110262","article-title":"The neuronal retromer can regulate both neuronal and microglial phenotypes of Alzheimer\u2019s disease","volume":"38","author":"Qureshi","year":"2022","journal-title":"Cell Reports"},{"issue":"12","key":"10.1016\/bs.irn.2023.06.006_bib107","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1523\/JNEUROSCI.1136-17.2017","article-title":"Microglia-Mediated synapse loss in Alzheimer\u2019s disease","volume":"38","author":"Rajendran","year":"2018","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/bs.irn.2023.06.006_bib108","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ebiom.2018.01.021","article-title":"Traumatic brain injury and Alzheimer\u2019s disease: The cerebrovascular link","volume":"28","author":"Ramos-Cejudo","year":"2018","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib109","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/HTR.0000000000000417","article-title":"Traumatic brain injury following military deployment: Evaluation of diagnosis and cause of injury","volume":"34","author":"Regasa","year":"2019","journal-title":"The Journal of Head Trauma Rehabilitation"},{"issue":"17","key":"10.1016\/bs.irn.2023.06.006_bib110","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1111\/bph.15488","article-title":"TLR4 pathway impairs synaptic number and cerebrovascular functions through astrocyte activation following traumatic brain injury","volume":"178","author":"Rosa","year":"2021","journal-title":"British Journal of Pharmacology"},{"issue":"8","key":"10.1016\/bs.irn.2023.06.006_bib111","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.2174\/1871527313666140806145540","article-title":"Poly (D,L-lactide-co-glycolide) nanoparticles loaded with cerebrolysin display neuroprotective activity in a rat model of concussive head injury","volume":"13","author":"Ruozi","year":"2014","journal-title":"CNS & Neurological Disorders Drug Targets"},{"key":"10.1016\/bs.irn.2023.06.006_bib112","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/bs.irn.2019.06.009","article-title":"Potentiation of spinal cord conduction and neuroprotection following nanodelivery of DL-3-n-butylphthalide in titanium implanted nanomaterial in a focal spinal cord injury induced functional outcome, blood-spinal cord barrier breakdown and edema formation","volume":"146","author":"Sahib","year":"2019","journal-title":"International Review of Neurobiology"},{"key":"10.1016\/bs.irn.2023.06.006_bib113","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.nbd.2018.12.018","article-title":"Low cerebral blood flow is a non-invasive biomarker of neuroinflammation after repetitive mild traumatic brain injury","volume":"124","author":"Sankar","year":"2019","journal-title":"Neurobiology of Disease"},{"issue":"3","key":"10.1016\/bs.irn.2023.06.006_bib114","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/jcbfm.1988.75","article-title":"Dexamethasone and indomethacin do not affect brain edema following head injury in rats","volume":"8","author":"Shapira","year":"1988","journal-title":"Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib115","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1213\/00000539-199307000-00028","article-title":"Blood-brain barrier permeability, cerebral edema, and neurologic function after closed head injury in rats","volume":"77","author":"Shapira","year":"1993","journal-title":"Anesthesia and Analgesia"},{"key":"10.1016\/bs.irn.2023.06.006_bib116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.irn.2019.06.005","article-title":"5-Hydroxytryptophan: A precursor of serotonin influences regional blood-brain barrier breakdown, cerebral blood flow, brain edema formation, and neuropathology","volume":"146","author":"Sharma","year":"2019","journal-title":"International Review of Neurobiology"},{"key":"10.1016\/bs.irn.2023.06.006_bib117","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/bs.pbr.2021.06.015","article-title":"Manganese nanoparticles induce blood-brain barrier disruption, cerebral blood flow reduction, edema formation and brain pathology associated with cognitive and motor dysfunctions","volume":"265","author":"Sharma","year":"2021","journal-title":"Progress in Brain Research"},{"key":"10.1016\/bs.irn.2023.06.006_bib118","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/bs.irn.2017.09.002","article-title":"Novel treatment strategies using TiO2-nanowired delivery of histaminergic drugs and antibodies to tau with cerebrolysin for superior neuroprotection in the pathophysiology of Alzheimer\u2019s disease","volume":"137","author":"Sharma","year":"2017","journal-title":"International Review of Neurobiology"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib119","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s12035-017-0740-y","article-title":"Cold environment exacerbates brain pathology and oxidative stress following traumatic brain injuries: Potential therapeutic effects of nanowired antioxidant compound H-290\/51","volume":"55","author":"Sharma","year":"2018","journal-title":"Molecular Neurobiology"},{"issue":"2","key":"10.1016\/bs.irn.2023.06.006_bib120","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s12035-013-8500-0","article-title":"Size- and age-dependent neurotoxicity of engineered metal nanoparticles in rats","volume":"48","author":"Sharma","year":"2013","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/bs.irn.2023.06.006_bib121","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/bs.irn.2019.06.011","article-title":"Neuroprotective effects of 5-HT3 receptor antagonist ondansetron on morphine withdrawal induced brain edema formation, blood-brain barrier dysfunction, neuronal injuries, glial activation and heat shock protein upregulation in the brain","volume":"146","author":"Sharma","year":"2019","journal-title":"International Review of Neurobiology"},{"key":"10.1016\/bs.irn.2023.06.006_bib122","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/B978-0-12-386986-9.00003-X","article-title":"The blood-brain barrier in Alzheimer\u2019s disease: Novel therapeutic targets and nanodrug delivery","volume":"102","author":"Sharma","year":"2012","journal-title":"International Review of Neurobiology"},{"issue":"3","key":"10.1016\/bs.irn.2023.06.006_bib123","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0168-0102(91)90058-7","article-title":"Increased blood-brain barrier permeability following acute short-term swimming exercise in conscious normotensive young rats","volume":"10","author":"Sharma","year":"1991","journal-title":"Neuroscience Research"},{"issue":"6","key":"10.1016\/bs.irn.2023.06.006_bib124","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1007\/s11064-023-03861-8","article-title":"Cerebrolysin attenuates exacerbation of neuropathic pain, blood-spinal cord barrier breakdown and cord pathology following chronic intoxication of engineered Ag, Cu or Al (50\u201360\u2009nm) nanoparticles","volume":"48","author":"Sharma","year":"2023","journal-title":"Neurochemical Research"},{"key":"10.1016\/bs.irn.2023.06.006_bib125","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/978-3-211-98811-4_65","article-title":"Influence of nanoparticles on blood-brain barrier permeability and brain edema formation in rats","volume":"106","author":"Sharma","year":"2010","journal-title":"Acta Neurochirurgica. Supplement"},{"issue":"2","key":"10.1016\/bs.irn.2023.06.006_bib126","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s12035-015-9252-9","article-title":"Exacerbation of methamphetamine neurotoxicity in cold and hot environments: Neuroprotective effects of an antioxidant compound H-290\/51","volume":"52","author":"Sharma","year":"2015","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/bs.irn.2023.06.006_bib127","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0079-6123(08)62334-1","article-title":"Age-related pathophysiology of the blood-brain barrier in heat stress","volume":"91","author":"Sharma","year":"1992","journal-title":"Progress in Brain Research"},{"key":"10.1016\/bs.irn.2023.06.006_bib128","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/bs.pbr.2021.06.005","article-title":"Neuroprotective effects of insulin like growth factor-1 on engineered metal nanoparticles Ag, Cu and Al induced blood-brain barrier breakdown, edema formation, oxidative stress, upregulation of neuronal nitric oxide synthase and brain pathology","volume":"266","author":"Sharma","year":"2021","journal-title":"Progress in Brain Research"},{"key":"10.1016\/bs.irn.2023.06.006_bib129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/bs.pbr.2021.04.008","article-title":"Alzheimer\u2019s disease neuropathology is exacerbated following traumatic brain injury. Neuroprotection by co-administration of nanowired mesenchymal stem cells and cerebrolysin with monoclonal antibodies to amyloid beta peptide","volume":"265","author":"Sharma","year":"2021","journal-title":"Progress in Brain Research"},{"key":"10.1016\/bs.irn.2023.06.006_bib130","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/bs.pbr.2019.03.009","article-title":"Nanowired delivery of cerebrolysin with neprilysin and p-Tau antibodies induces superior neuroprotection in Alzheimer\u2019s disease","volume":"245","author":"Sharma","year":"2019","journal-title":"Progress in Brain Research"},{"issue":"9","key":"10.1016\/bs.irn.2023.06.006_bib131","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.2174\/1871527315666160902145145","article-title":"Pathophysiology of blood-brain barrier in brain injury in cold and hot environments: Novel drug targets for neuroprotection","volume":"15","author":"Sharma","year":"2016","journal-title":"CNS & Neurological Disorders Drug Targets"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib132","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/s12035-017-0742-9","article-title":"Co-administration of TiO2 nanowired mesenchymal stem cells with cerebrolysin potentiates neprilysin level and reduces brain pathology in Alzheimer\u2019s disease","volume":"55","author":"Sharma","year":"2018","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/bs.irn.2023.06.006_bib133","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/bs.irn.2019.06.006","article-title":"Anesthetics influence concussive head injury induced blood-brain barrier breakdown, brain edema formation, cerebral blood flow, serotonin levels, brain pathology and functional outcome","volume":"146","author":"Sharma","year":"2019","journal-title":"International Review of Neurobiology"},{"key":"10.1016\/bs.irn.2023.06.006_bib134","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/bs.pbr.2021.06.014","article-title":"Superior antioxidant and anti-ischemic neuroprotective effects of cerebrolysin in heat stroke following intoxication of engineered metal Ag and Cu nanoparticles: A comparative biochemical and physiological study with other stroke therapies","volume":"266","author":"Sharma","year":"2021","journal-title":"Progress in Brain Research"},{"issue":"6","key":"10.1016\/bs.irn.2023.06.006_bib135","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2217\/nmt-2016-0037","article-title":"Alzheimer\u2019s disease: Cerebrolysin and nanotechnology as a therapeutic strategy","volume":"6","author":"Sharma","year":"2016","journal-title":"Neurodegenerative Disease Management"},{"issue":"1\u20132","key":"10.1016\/bs.irn.2023.06.006_bib136","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0006-8993(90)91029-G","article-title":"Changes in blood-brain barrier and cerebral blood flow following elevation of circulating serotonin level in anesthetized rats","volume":"517","author":"Sharma","year":"1990","journal-title":"Brain Research"},{"key":"10.1016\/bs.irn.2023.06.006_bib137","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1196\/annals.1403.022","article-title":"Antibodies to serotonin attenuate closed head injury induced blood brain barrier disruption and brain pathology","volume":"1122","author":"Sharma","year":"2007","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/bs.irn.2023.06.006_bib138","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/978-3-211-98811-4_56","article-title":"Antibodies to dynorphin a (1-17) attenuate closed head injury induced blood-brain barrier disruption, brain edema formation and brain pathology in the rat","volume":"106","author":"Sharma","year":"2010","journal-title":"Acta Neurochirurgica. Supplement"},{"key":"10.1016\/bs.irn.2023.06.006_bib139","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/bs.pbr.2020.09.009","article-title":"Protein kinase inhibitors in traumatic brain injury and repair: New roles of nanomedicine","volume":"258","author":"Sharma","year":"2020","journal-title":"Progress in Brain Research"},{"key":"10.1016\/bs.irn.2023.06.006_bib140","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/978-3-211-98811-4_64","article-title":"A new antioxidant compound H-290\/51 attenuates nanoparticle induced neurotoxicity and enhances neurorepair in hyperthermia","volume":"106","author":"Sharma","year":"2010","journal-title":"Acta Neurochirurgica. Supplement"},{"key":"10.1016\/bs.irn.2023.06.006_bib141","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0079-6123(06)62013-X","article-title":"Nanoparticles aggravate heat stress induced cognitive deficits, blood-brain barrier disruption, edema formation and brain pathology","volume":"162","author":"Sharma","year":"2007","journal-title":"Progress in Brain Research"},{"issue":"9","key":"10.1016\/bs.irn.2023.06.006_bib142","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.2174\/187152731509161007123931","article-title":"Editorial: (Thematic Issue) Novel concepts on the blood-brain barrier and brain pathology. New therapeutic approaches","volume":"15","author":"Sharma","year":"2016","journal-title":"CNS & Neurological Disorders Drug Targets"},{"key":"10.1016\/bs.irn.2023.06.006_bib143","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/j.1749-6632.1997.tb51749.x","article-title":"Involvement of nitric oxide in the pathophysiology of acute heat stress in the rat. Influence of a new antioxidant compound H-290\/51","volume":"813","author":"Sharma","year":"1997","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/bs.irn.2023.06.006_bib144","first-page":"269","article-title":"Role of neurochemicals in brain edema and cell changes following hyperthermic brain injury in the rat","volume":"70","author":"Sharma","year":"1997","journal-title":"Acta Neurochirurgica. Supplement"},{"key":"10.1016\/bs.irn.2023.06.006_bib145","first-page":"65","article-title":"Role of serotonin and prostaglandins in brain edema induced by heat stress. An experimental study in the young rat","volume":"60","author":"Sharma","year":"1994","journal-title":"Acta Neurochirurgica. Supplementum"},{"key":"10.1016\/bs.irn.2023.06.006_bib146","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0079-6123(08)62043-9","article-title":"Pathophysiology of brain edema and cell changes following hyperthermic brain injury","volume":"115","author":"Sharma","year":"1998","journal-title":"Progress in Brain Research"},{"issue":"4","key":"10.1016\/bs.irn.2023.06.006_bib147","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/0306-4522(92)90277-9","article-title":"Acute systemic heat stress increases glial fibrillary acidic protein immunoreactivity in brain: experimental observations in conscious normotensive young rats","volume":"48","author":"Sharma","year":"1992","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib148","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s00702-010-0542-0","article-title":"Blood-CNS barrier, neurodegeneration and neuroprotection: recent therapeutic advancements and nano-drug delivery","volume":"118","author":"Sharma","year":"2011","journal-title":"Journal of Neural Transmission (Vienna)"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib149","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0028-3908(87)90049-9","article-title":"Effect of captopril (a converting enzyme inhibitor) on blood-brain barrier permeability and cerebral blood flow in normotensive rats","volume":"26","author":"Sharma","year":"1987","journal-title":"Neuropharmacology"},{"issue":"17","key":"10.1016\/bs.irn.2023.06.006_bib150","doi-asserted-by":"crossref","first-page":"4483","DOI":"10.1073\/pnas.1721694115","article-title":"\u03b2-Amyloid accumulation in the human brain after one night of sleep deprivation","volume":"115","author":"Shokri-Kojori","year":"2018","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3 Suppl","key":"10.1016\/bs.irn.2023.06.006_bib151","first-page":"S105","article-title":"Alzheimer\u2019s disease prevalence, costs, and prevention for military personnel and veterans","volume":"10","author":"Sibener","year":"2014","journal-title":"Alzheimer\u2019s & Dementia: The Journal of the Alzheimer\u2019s Association"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib152","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12974-022-02565-0","article-title":"Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer\u2019s disease","volume":"19","author":"Singh","year":"2022","journal-title":"Journal of Neuroinflammation"},{"issue":"12","key":"10.1016\/bs.irn.2023.06.006_bib153","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/j.jalz.2018.08.011","article-title":"Military-related risk factors for dementia","volume":"14","author":"Snyder","year":"2018","journal-title":"Alzheimer\u2019s & Dementia: The Journal of the Alzheimer\u2019s Association"},{"key":"10.1016\/bs.irn.2023.06.006_bib154","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2022.107306","article-title":"Shared pathophysiology: Understanding stroke and Alzheimer\u2019s disease","volume":"218","author":"Sriram","year":"2022","journal-title":"Clinical Neurology and Neurosurgery"},{"issue":"8","key":"10.1016\/bs.irn.2023.06.006_bib155","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/alz.12502","article-title":"Tau phosphorylation sites serine202 and serine396 are differently altered in chronic traumatic encephalopathy and Alzheimer\u2019s disease","volume":"18","author":"Stathas","year":"2022","journal-title":"Alzheimer\u2019s & Dementia: The Journal of the Alzheimer\u2019s Association"},{"issue":"2","key":"10.1016\/bs.irn.2023.06.006_bib156","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s11682-022-00750-6","article-title":"Altered cerebral blood flow in older adults with Alzheimer\u2019s disease: a systematic review","volume":"17","author":"Swinford","year":"2023","journal-title":"Brain Imaging and Behavior"},{"issue":"6","key":"10.1016\/bs.irn.2023.06.006_bib157","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-026992","article-title":"Sleep-cognition hypothesis in maritime pilots, what is the effect of long-term work-related poor sleep on cognition and amyloid accumulation in healthy middle-aged maritime pilots: Methodology of a case-control study","volume":"9","author":"Thomas","year":"2019","journal-title":"BMJ Open"},{"issue":"7","key":"10.1016\/bs.irn.2023.06.006_bib158","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/geronb\/gbac007","article-title":"Childhood stressors, relationship quality, and cognitive health in later life","volume":"77","author":"Thomas","year":"2022","journal-title":"The Journals of Gerontology. Series B, Psychological Sciences and Social Sciences"},{"issue":"4","key":"10.1016\/bs.irn.2023.06.006_bib159","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.3233\/JAD-161088","article-title":"Oxidative stress, synaptic dysfunction, and Alzheimer\u2019s disease","volume":"57","author":"T\u00f6nnies","year":"2017","journal-title":"Journal of Alzheimer\u2019s Disease: JAD"},{"issue":"2","key":"10.1016\/bs.irn.2023.06.006_bib160","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3233\/JAD-200711","article-title":"Therapeutic potential of TNF-\u03b1 inhibition for Alzheimer\u2019s disease prevention","volume":"78","author":"Torres-Acosta","year":"2020","journal-title":"Journal of Alzheimer\u2019s Disease: JAD"},{"key":"10.1016\/bs.irn.2023.06.006_bib161","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.pnpbp.2018.08.011","article-title":"The opioid system in stress-induced memory disorders: From basic mechanisms to clinical implications in post-traumatic stress disorder and Alzheimer\u2019s disease","volume":"88","author":"Torres-Berrio","year":"2019","journal-title":"Progress in Neuro-psychopharmacology & Biological Psychiatry"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib162","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13195-022-00976-y","article-title":"A comparison between tau and amyloid-\u03b2 cerebrospinal fluid biomarkers in chronic traumatic encephalopathy and Alzheimer disease","volume":"14","author":"Turk","year":"2022","journal-title":"Alzheimer\u2019s Research & Therapy"},{"issue":"7","key":"10.1016\/bs.irn.2023.06.006_bib163","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.3390\/ijms22073365","article-title":"SSAO\/VAP-1 in cerebrovascular disorders: A potential therapeutic target for stroke and Alzheimer\u2019s disease","volume":"22","author":"Unzeta","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/bs.irn.2023.06.006_bib164","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/3-211-30714-1_34","article-title":"Zinc protoporphyrin IX attenuates closed head injury-induced edema formation, blood-brain barrier disruption, and serotonin levels in the rat","volume":"96","author":"Vannemreddy","year":"2006","journal-title":"Acta Neurochirurgica. Supplement"},{"issue":"8","key":"10.1016\/bs.irn.2023.06.006_bib165","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1080\/02699052.2022.2109746","article-title":"Chronic cerebral blood flow alterations in traumatic brain injury and sports-related concussions","volume":"36","author":"Vedung","year":"2022","journal-title":"Brain Injury: [BI]"},{"issue":"2","key":"10.1016\/bs.irn.2023.06.006_bib166","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3233\/JAD-160527","article-title":"Stroke, vascular dementia, and Alzheimer\u2019s disease: Molecular links","volume":"54","author":"Vijayan","year":"2016","journal-title":"Journal of Alzheimer\u2019s Disease: JAD"},{"issue":"3","key":"10.1016\/bs.irn.2023.06.006_bib167","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41401-020-00583-3","article-title":"DL-3-n-butylphthalide ameliorates diabetes-associated cognitive decline by enhancing PI3K\/Akt signaling and suppressing oxidative stress","volume":"42","author":"Wang","year":"2021","journal-title":"Acta Pharmacologica Sinica"},{"issue":"11","key":"10.1016\/bs.irn.2023.06.006_bib168","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1089\/ars.2017.7440","article-title":"Dl-3-n-Butylphthalide inhibits NLRP3 inflammasome and mitigates Alzheimer\u2019s-like pathology via Nrf2-TXNIP-TrX axis","volume":"30","author":"Wang","year":"2019","journal-title":"Antioxidants & Redox Signaling"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib169","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12974-020-01863-9","article-title":"Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injury","volume":"17","author":"Wang","year":"2020","journal-title":"Journal of Neuroinflammation"},{"issue":"3","key":"10.1016\/bs.irn.2023.06.006_bib170","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1007\/s12035-020-02171-2","article-title":"Estrogen attenuates traumatic brain injury by inhibiting the activation of microglia and astrocyte-mediated neuroinflammatory responses","volume":"58","author":"Wang","year":"2021","journal-title":"Molecular Neurobiology"},{"issue":"5","key":"10.1016\/bs.irn.2023.06.006_bib171","doi-asserted-by":"crossref","first-page":"338","DOI":"10.2174\/1871527317666180612125843","article-title":"Dl-3-n-Butylphthalide (NBP): A promising therapeutic agent for ischemic stroke","volume":"17","author":"Wang","year":"2018","journal-title":"CNS & Neurological Disorders Drug Targets"},{"issue":"13","key":"10.1016\/bs.irn.2023.06.006_bib172","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1089\/neu.2015.4072","article-title":"Cerebral blood flow alterations in acute sport-related concussion","volume":"33","author":"Wang","year":"2016","journal-title":"Journal of Neurotrauma"},{"issue":"7","key":"10.1016\/bs.irn.2023.06.006_bib173","first-page":"4719","article-title":"The effect and mechanism of dl-3-n-butylphthalide on angiogenesis in a rat model of chronic myocardial ischemia","volume":"14","author":"Wang","year":"2022","journal-title":"American Journal of Translational Research"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib174","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s40478-021-01236-0","article-title":"RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury","volume":"9","author":"Wehn","year":"2021","journal-title":"Acta Neuropathologica Communications"},{"issue":"4","key":"10.1016\/bs.irn.2023.06.006_bib175","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.jalz.2013.03.005","article-title":"Military risk factors for Alzheimer\u2019s disease","volume":"9","author":"Weiner","year":"2013","journal-title":"Alzheimer\u2019s & Dementia: The Journal of the Alzheimer\u2019s Association"},{"issue":"8","key":"10.1016\/bs.irn.2023.06.006_bib176","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.cmi.2020.09.031","article-title":"Cerebrospinal fluid biomarkers of brain injury, inflammation and synaptic autoimmunity predict long-term neurocognitive outcome in herpes simplex encephalitis","volume":"27","author":"Westman","year":"2021","journal-title":"Clinical Microbiology and Infection: The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases"},{"issue":"1","key":"10.1016\/bs.irn.2023.06.006_bib177","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/ana.25726","article-title":"Post-traumatic stress disorder is associated with further increased Parkinson\u2019s disease risk in veterans with traumatic brain injury","volume":"88","author":"White","year":"2020","journal-title":"Annals of Neurology"},{"issue":"4","key":"10.1016\/bs.irn.2023.06.006_bib178","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.nec.2016.05.008","article-title":"Cerebral edema in traumatic brain injury: Pathophysiology and prospective therapeutic targets","volume":"27","author":"Winkler","year":"2016","journal-title":"Neurosurgery Clinics of North America"},{"issue":"7","key":"10.1016\/bs.irn.2023.06.006_bib179","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1523\/JNEUROSCI.2469-20.2020","article-title":"Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia","volume":"41","author":"Witcher","year":"2021","journal-title":"The Journal of Neuroscience"},{"issue":"25","key":"10.1016\/bs.irn.2023.06.006_bib180","article-title":"Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer\u2019s disease pathogenesis","volume":"118","author":"Wu","year":"2021","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7","key":"10.1016\/bs.irn.2023.06.006_bib181","doi-asserted-by":"crossref","first-page":"6528","DOI":"10.3390\/ijms24076528","article-title":"Multifaceted roles of aquaporins in the pathogenesis of Alzheimer\u2019s disease","volume":"24","author":"Yamada","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"issue":"6","key":"10.1016\/bs.irn.2023.06.006_bib182","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3171\/jns.1985.63.6.0830","article-title":"Acute brain edema in fatal head injury: Analysis by dynamic CT scanning","volume":"63","author":"Yoshino","year":"1985","journal-title":"Journal of Neurosurgery"},{"issue":"9","key":"10.1016\/bs.irn.2023.06.006_bib183","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1111\/cns.13899","article-title":"Phagocytic microglia and macrophages in brain injury and repair","volume":"28","author":"Yu","year":"2022","journal-title":"CNS Neuroscience & Therapeutics"},{"issue":"4","key":"10.1016\/bs.irn.2023.06.006_bib184","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/bpa.12690","article-title":"Distribution and prognostic impact of microglia\/macrophage subpopulations in gliomas","volume":"29","author":"Zeiner","year":"2019","journal-title":"Brain Pathology (Zurich, Switzerland)"},{"issue":"5","key":"10.1016\/bs.irn.2023.06.006_bib185","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.21037\/jtd-22-585","article-title":"Dl-3-n-butylphthalide attenuates myocardial ischemia reperfusion injury by suppressing oxidative stress and regulating cardiac mitophagy via the PINK1\/Parkin pathway in rats","volume":"14","author":"Zhang","year":"2022","journal-title":"Journal of Thoracic Disease"},{"key":"10.1016\/bs.irn.2023.06.006_bib186","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.987293","article-title":"DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress","volume":"13","author":"Zhang","year":"2023","journal-title":"Frontiers in Pharmacology"},{"key":"10.1016\/bs.irn.2023.06.006_bib187","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101450","article-title":"Cerebral blood flow in mild cognitive impairment and Alzheimer\u2019s disease: A systematic review and meta-analysis","volume":"71","author":"Zhang","year":"2021","journal-title":"Ageing Research Reviews"},{"issue":"17","key":"10.1016\/bs.irn.2023.06.006_bib188","doi-asserted-by":"crossref","first-page":"21642","DOI":"10.18632\/aging.203508","article-title":"Astrocyte-derived exosomes protect hippocampal neurons after traumatic brain injury by suppressing mitochondrial oxidative stress and apoptosis","volume":"13","author":"Zhang","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/bs.irn.2023.06.006_bib189","first-page":"7232457","article-title":"Role of butylphthalide in immunity and inflammation: Butylphthalide may be a potential therapy for anti-inflammation and immunoregulation","volume":"2022","author":"Zhang","year":"2022","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/bs.irn.2023.06.006_bib190","article-title":"Neuroinflammation following traumatic brain injury: Take it seriously or not","volume":"13","author":"Zheng","year":"2022","journal-title":"Frontiers in Immunology"},{"issue":"9","key":"10.1016\/bs.irn.2023.06.006_bib191","doi-asserted-by":"crossref","first-page":"968","DOI":"10.4103\/1673-5374.133148","article-title":"Acupuncture and moxibustion reduces neuronal edema in Alzheimer\u2019s disease rats","volume":"9","author":"Zhou","year":"2014","journal-title":"Neural Regeneration Research"},{"issue":"3","key":"10.1016\/bs.irn.2023.06.006_bib192","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/ene.15190","article-title":"Causal effect of insulin resistance on small vessel stroke and Alzheimer\u2019s disease: A Mendelian randomization analysis","volume":"29","author":"Zhou","year":"2022","journal-title":"European Journal of Neurology: The Official Journal of the European Federation of Neurological Societies"},{"key":"10.1016\/bs.irn.2023.06.006_bib193","article-title":"PET imaging of neuroinflammation in Alzheimer\u2019s disease","volume":"12","author":"Zhou","year":"2021","journal-title":"Frontiers in Immunology"},{"issue":"6","key":"10.1016\/bs.irn.2023.06.006_bib194","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1007\/s12035-021-02293-1","article-title":"Infliximab can improve traumatic brain injury by suppressing the tumor necrosis factor alpha pathway","volume":"58","author":"Zhou","year":"2021","journal-title":"Molecular Neurobiology"},{"issue":"1\u20133","key":"10.1016\/bs.irn.2023.06.006_bib195","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ejphar.2004.07.027","article-title":"Recent pharmacological studies on natural products in China","volume":"500","author":"Zhu","year":"2004","journal-title":"European Journal of Pharmacology"},{"issue":"2","key":"10.1016\/bs.irn.2023.06.006_bib196","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0306-4522(91)90125-8","article-title":"Altered glial fibrillary acidic protein immunoreactivity in rat brain following chronic hypoxia","volume":"40","author":"Zimmer","year":"1991","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/bs.irn.2023.06.006_bib197","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1038\/nrn3114","article-title":"Neurovascular pathways to neurodegeneration in Alzheimer\u2019s disease and other disorders","volume":"12","author":"Zlokovic","year":"2011","journal-title":"Nature Reviews. Neuroscience"}],"container-title":["International Review of Neurobiology","Nanowired Delivery of Drugs and Antibodies for Neuroprotection in Brain Diseases with Co-Morbidity Factors Part B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774223000545?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774223000545?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T05:54:31Z","timestamp":1730181271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0074774223000545"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9780443294686"],"references-count":197,"URL":"https:\/\/doi.org\/10.1016\/bs.irn.2023.06.006","relation":{},"ISSN":["0074-7742"],"issn-type":[{"value":"0074-7742","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}