{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T23:19:32Z","timestamp":1781824772719,"version":"3.54.5"},"reference-count":210,"publisher":"Elsevier","isbn-type":[{"value":"9780443137297","type":"print"}],"license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["W81XWH2210583"],"award-info":[{"award-number":["W81XWH2210583"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023]]},"DOI":"10.1016\/bs.irn.2023.08.004","type":"book-chapter","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T03:16:00Z","timestamp":1694661360000},"page":"67-113","source":"Crossref","is-referenced-by-count":10,"title":["Involvement of brain metabolism in neurodevelopmental disorders"],"prefix":"10.1016","author":[{"given":"Pavel","family":"Kotchetkov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Blakeley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Lacoste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/bs.irn.2023.08.004_bib1","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1023\/A:1021191729865","article-title":"Potential role of cerebral glutathione in the maintenance of blood-brain barrier integrity in rat","volume":"24","author":"Agarwal","year":"1999","journal-title":"Neurochemical Research"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib2","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2165\/00003495-199958020-00002","article-title":"Adenosine triphosphate: Established and potential clinical applications","volume":"58","author":"Agteresch","year":"1999","journal-title":"Drugs"},{"issue":"7","key":"10.1016\/bs.irn.2023.08.004_bib3","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/npp.2015.26","article-title":"Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice","volume":"40","author":"Aida","year":"2015","journal-title":"Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib4","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s10787-013-0181-9","article-title":"Effect of diclofenac and antidepressants on the inflammatory response in astrocyte cell culture","volume":"21","author":"Al-Amin","year":"2013","journal-title":"Inflammopharmacology"},{"issue":"10\u201311","key":"10.1016\/bs.irn.2023.08.004_bib5","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.clinbiochem.2009.03.011","article-title":"Metabolic biomarkers related to oxidative stress and antioxidant status in Saudi autistic children","volume":"42","author":"Al-Gadani","year":"2009","journal-title":"Clinical Biochemistry"},{"issue":"26","key":"10.1016\/bs.irn.2023.08.004_bib6","doi-asserted-by":"crossref","first-page":"15294","DOI":"10.1073\/pnas.261560998","article-title":"Different responses of astrocytes and neurons to nitric oxide: The role of glycolytically generated ATP in astrocyte protection","volume":"98","author":"Almeida","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib7","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/ncb1080","article-title":"Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway","volume":"6","author":"Almeida","year":"2004","journal-title":"Nature Cell Biology"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-neuro-071714-033835","article-title":"Neuronal and vascular interactions","volume":"38","author":"Andreone","year":"2015","journal-title":"Annual Review of Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41572-019-0143-7","article-title":"Down syndrome","volume":"6","author":"Antonarakis","year":"2020","journal-title":"Nature Reviews Disease Primers"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib10","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1161\/01.RES.0000182903.16652.d7","article-title":"Endothelial\/pericyte interactions","volume":"97","author":"Armulik","year":"2005","journal-title":"Circulation Research"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.devcel.2011.07.001","article-title":"Pericytes: Developmental, physiological, and pathological perspectives, problems, and promises","volume":"21","author":"Armulik","year":"2011","journal-title":"Developmental Cell"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12929-015-0138-y","article-title":"Down syndrome: An insight of the disease","volume":"22","author":"Asim","year":"2015","journal-title":"Journal of Biomedical Science"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib13","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s10803-015-2672-6","article-title":"Persistent angiogenesis in the autism brain: An immunocytochemical study of postmortem cortex, brainstem and cerebellum","volume":"46","author":"Azmitia","year":"2016","journal-title":"Journal of Autism and Developmental Disorders"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2003.12.016","article-title":"The blood-brain barrier: An overview: Structure, regulation, and clinical implications","volume":"16","author":"Ballabh","year":"2004","journal-title":"Neurobiology of Disease"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib15","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1046\/j.1471-4159.1999.721769.x","article-title":"Neuronal apoptosis in mouse trisomy 16: Mediation by caspases","volume":"72","author":"Bambrick","year":"1999","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/bs.irn.2023.08.004_bib16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neulet.2018.06.004","article-title":"Alterations in neuronal cytoskeletal and astrocytic proteins content in the brain of the autistic-like mouse strain C58\/J","volume":"682","author":"Bar\u00f3n-Mendoza","year":"2018","journal-title":"Neuroscience Letters"},{"issue":"1\u20132","key":"10.1016\/bs.irn.2023.08.004_bib17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.brainresrev.2009.10.002","article-title":"Glucose and lactate supply to the synapse","volume":"63","author":"Barros","year":"2010","journal-title":"Brain Research Reviews"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11064-020-02964-w","article-title":"Aerobic glycolysis in the brain: Warburg and Crabtree Contra Pasteur","volume":"46","author":"Barros","year":"2021","journal-title":"Neurochemical Research"},{"issue":"39","key":"10.1016\/bs.irn.2023.08.004_bib19","doi-asserted-by":"crossref","first-page":"64932","DOI":"10.18632\/oncotarget.18117","article-title":"Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells","volume":"8","author":"Bayin","year":"2017","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1000016","article-title":"A novel function for fragile X mental retardation protein in translational activation","volume":"7","author":"Bechara","year":"2009","journal-title":"PLoS Biology"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.gep.2009.11.005","article-title":"Autism susceptibility candidate 2 (Auts2) encodes a nuclear protein expressed in developing brain regions implicated in autism neuropathology","volume":"10","author":"Bedogni","year":"2010","journal-title":"Gene Expression Patterns: GEP"},{"issue":"5","key":"10.1016\/bs.irn.2023.08.004_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112485","article-title":"16p11.2 haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice","volume":"42","author":"B\u00e9land-Millar","year":"2023","journal-title":"Cell Reports"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib23","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","article-title":"Brain energy metabolism: Focus on astrocyte-neuron metabolic cooperation","volume":"14","author":"B\u00e9langer","year":"2011","journal-title":"Cell Metabolism"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib24","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/cne.22009","article-title":"Widespread changes in dendritic and axonal morphology in Mecp2-mutant mouse models of Rett syndrome: Evidence for disruption of neuronal networks","volume":"514","author":"Belichenko","year":"2009","journal-title":"The Journal of Comparative Neurology"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib25","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.plefa.2004.03.008","article-title":"Essential fatty acids and phospholipase A2 in autistic spectrum disorders","volume":"71","author":"Bell","year":"2004","journal-title":"Prostaglandins, Leukotrienes, and Essential Fatty Acids"},{"issue":"7501","key":"10.1016\/bs.irn.2023.08.004_bib26","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nature13324","article-title":"Mfsd2a is critical for the formation and function of the blood\u2013brain barrier","volume":"509","author":"Ben-Zvi","year":"2014","journal-title":"Nature"},{"issue":"15","key":"10.1016\/bs.irn.2023.08.004_bib27","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1212\/WNL.0000000000000328","article-title":"Brain glucose transporters: Implications for neurologic disease","volume":"82","author":"Benarroch","year":"2014","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib28","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1097\/00004647-199611000-00001","article-title":"Selective distribution of lactate dehydrogenase isoenzymes in neurons and astrocytes of human brain","volume":"16","author":"Bittar","year":"1996","journal-title":"Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib29","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/jcbfm.2009.197","article-title":"Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy","volume":"30","author":"Boumezbeur","year":"2010","journal-title":"Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib30","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1111\/j.1460-9568.2006.05056.x","article-title":"Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: A comparative NMR study","volume":"24","author":"Bouzier-Sore","year":"2006","journal-title":"The European Journal of Neuroscience"},{"issue":"11","key":"10.1016\/bs.irn.2023.08.004_bib31","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1097\/01.WCB.0000091761.61714.25","article-title":"Lactate is a preferential oxidative energy substrate over glucose for neurons in culture","volume":"23","author":"Bouzier-Sore","year":"2003","journal-title":"Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib32","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1083\/jcb.40.3.648","article-title":"Junctions between intimately apposed cell membranes in the vertebrate brain","volume":"40","author":"Brightman","year":"1969","journal-title":"The Journal of Cell Biology"},{"issue":"9","key":"10.1016\/bs.irn.2023.08.004_bib33","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1177\/0271678X221080324","article-title":"Activation of lactate receptor HCAR1 down-modulates neuronal activity in rodent and human brain tissue","volume":"42","author":"Briquet","year":"2022","journal-title":"Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib34","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/j.1471-4159.2004.02421.x","article-title":"Brain glycogen re-awakened","volume":"89","author":"Brown","year":"2004","journal-title":"Journal of Neurochemistry"},{"issue":"5","key":"10.1016\/bs.irn.2023.08.004_bib35","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0896-6273(02)00604-9","article-title":"Altered metabolism of the amyloid beta precursor protein is associated with mitochondrial dysfunction in Down\u2019s syndrome","volume":"33","author":"Busciglio","year":"2002","journal-title":"Neuron"},{"issue":"6559","key":"10.1016\/bs.irn.2023.08.004_bib36","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/378776a0","article-title":"Apoptosis and increased generation of reactive oxygen species in Down\u2019s syndrome neurons in vitro","volume":"378","author":"Busciglio","year":"1995","journal-title":"Nature"},{"issue":"11","key":"10.1016\/bs.irn.2023.08.004_bib37","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.15252\/embj.201695810","article-title":"Brain metabolism in health, aging, and neurodegeneration","volume":"36","author":"Camandola","year":"2017","journal-title":"The EMBO Journal"},{"issue":"19","key":"10.1016\/bs.irn.2023.08.004_bib38","doi-asserted-by":"crossref","first-page":"13831","DOI":"10.1074\/jbc.M112.441055","article-title":"Enhanced asynchronous Ca(2+) oscillations associated with impaired glutamate transport in cortical astrocytes expressing Fmr1 gene premutation expansion","volume":"288","author":"Cao","year":"2013","journal-title":"The Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib39","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/0003-9861(90)90327-U","article-title":"Structure and assembly of cytochrome c oxidase","volume":"280","author":"Capaldi","year":"1990","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"7347","key":"10.1016\/bs.irn.2023.08.004_bib40","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature"},{"issue":"7","key":"10.1016\/bs.irn.2023.08.004_bib41","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1002\/jcp.25711","article-title":"SIRT1-SIRT3 axis regulates cellular response to oxidative stress and etoposide","volume":"232","author":"Carnevale","year":"2017","journal-title":"Journal of Cellular Physiology"},{"issue":"9","key":"10.1016\/bs.irn.2023.08.004_bib42","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022111189","article-title":"The blood-brain barrier-A metabolic ecosystem","volume":"41","author":"Castro","year":"2022","journal-title":"The EMBO Journal"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib43","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/0271678X17720816","article-title":"Occludin regulates glucose uptake and ATP production in pericytes by influencing AMP-activated protein kinase activity","volume":"38","author":"Castro","year":"2018","journal-title":"Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib44","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.neuron.2007.10.001","article-title":"The story of Rett syndrome: From clinic to neurobiology","volume":"56","author":"Chahrour","year":"2007","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib45","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.pathophys.2006.05.007","article-title":"Oxidative stress in autism","volume":"13","author":"Chauhan","year":"2006","journal-title":"Pathophysiology: The Official Journal of the International Society for Pathophysiology\/ISP"},{"issue":"21","key":"10.1016\/bs.irn.2023.08.004_bib46","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1016\/j.lfs.2004.04.038","article-title":"Oxidative stress in autism: Increased lipid peroxidation and reduced serum levels of ceruloplasmin and transferrin--The antioxidant proteins","volume":"75","author":"Chauhan","year":"2004","journal-title":"Life Sciences"},{"key":"10.1016\/bs.irn.2023.08.004_bib47","doi-asserted-by":"crossref","first-page":"1151162","DOI":"10.3389\/fnmol.2023.1151162","article-title":"Glycolysis mediates neuron specific histone acetylation in valproic acid-induced human excitatory neuron differentiation","volume":"16","author":"Chen","year":"2023","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"10.1016\/bs.irn.2023.08.004_bib48","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fnmol.2017.00034","article-title":"Metabolic dysfunction underlying autism spectrum disorder and potential treatment approaches","volume":"10","author":"Cheng","year":"2017","journal-title":"Frontiers in Molecular Neuroscience"},{"issue":"10","key":"10.1016\/bs.irn.2023.08.004_bib49","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.tins.2015.08.003","article-title":"The molecular constituents of the blood-brain barrier","volume":"38","author":"Chow","year":"2015","journal-title":"Trends in Neurosciences"},{"issue":"16","key":"10.1016\/bs.irn.2023.08.004_bib50","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1001\/jama.2013.2270","article-title":"Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism","volume":"309","author":"Christensen","year":"2013","journal-title":"JAMA: The Journal of the American Medical Association"},{"issue":"12","key":"10.1016\/bs.irn.2023.08.004_bib51","doi-asserted-by":"crossref","first-page":"3996","DOI":"10.2337\/db15-0640","article-title":"Measurements of gluconeogenesis and glycogenolysis: A methodological review","volume":"64","author":"Chung","year":"2015","journal-title":"Diabetes"},{"issue":"45","key":"10.1016\/bs.irn.2023.08.004_bib52","doi-asserted-by":"crossref","first-page":"15298","DOI":"10.1523\/JNEUROSCI.0762-10.2010","article-title":"Predominant enhancement of glucose uptake in astrocytes versus neurons during activation of the somatosensory cortex","volume":"30","author":"Chuquet","year":"2010","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib53","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.ajhg.2009.09.007","article-title":"Incidence of fragile X syndrome by newborn screening for methylated FMR1 DNA","volume":"85","author":"Coffee","year":"2009","journal-title":"American Journal of Human Genetics"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib54","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/00004647-199801000-00003","article-title":"Interictal seizure resections show two configurations of endothelial Glut1 glucose transporter in the human blood-brain barrier","volume":"18","author":"Cornford","year":"1998","journal-title":"Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib55","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/jcbfm.1994.15","article-title":"The human brain GLUT1 glucose transporter: Ultrastructural localization to the blood-brain barrier endothelia","volume":"14","author":"Cornford","year":"1994","journal-title":"Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib56","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1177\/088307389400900419","article-title":"Neuropathology of Rett syndrome: Case report with neuronal and mitochondrial abnormalities in the brain","volume":"9","author":"Cornford","year":"1994","journal-title":"Journal of Child Neurology"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib57","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1006\/abbi.1997.0109","article-title":"Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress","volume":"342","author":"Crawford","year":"1997","journal-title":"Archives of Biochemistry and Biophysics"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib58","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.stem.2008.07.003","article-title":"A perivascular origin for mesenchymal stem cells in multiple human organs","volume":"3","author":"Crisan","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"5","key":"10.1016\/bs.irn.2023.08.004_bib59","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1002\/ana.23648","article-title":"The blood-brain barrier in health and disease","volume":"72","author":"Daneman","year":"2012","journal-title":"Annals of Neurology"},{"issue":"7323","key":"10.1016\/bs.irn.2023.08.004_bib60","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nature09513","article-title":"Pericytes are required for blood-brain barrier integrity during embryogenesis","volume":"468","author":"Daneman","year":"2010","journal-title":"Nature"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib61","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3233\/JAD-160945","article-title":"Neurons derived from induced pluripotent stem cells of patients with Down syndrome reproduce early stages of Alzheimer\u2019s disease type pathology in vitro","volume":"56","author":"Dashinimaev","year":"2017","journal-title":"Journal of Alzheimer\u2019s Disease: JAD"},{"issue":"12","key":"10.1016\/bs.irn.2023.08.004_bib62","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1101\/gr.116764.110","article-title":"A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model","volume":"21","author":"Davidovic","year":"2011","journal-title":"Genome Research"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib63","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cell.2013.06.037","article-title":"Role of PFKFB3-driven glycolysis in vessel sprouting","volume":"154","author":"De Bock","year":"2013","journal-title":"Cell"},{"issue":"23","key":"10.1016\/bs.irn.2023.08.004_bib64","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1523\/JNEUROSCI.2092-18.2019","article-title":"The lactate receptor HCAR1 modulates neuronal network activity through the activation of G(alpha) and G(betagamma) subunits","volume":"39","author":"de Castro Abrantes","year":"2019","journal-title":"The Journal of Neuroscience"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib65","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.cell.2012.02.032","article-title":"Cellular metabolism and disease: What do metabolic outliers teach us","volume":"148","author":"DeBerardinis","year":"2012","journal-title":"Cell"},{"issue":"5","key":"10.1016\/bs.irn.2023.08.004_bib66","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.pediatrneurol.2012.11.001","article-title":"Rett syndrome and epilepsy: An update for child neurologists","volume":"48","author":"Dolce","year":"2013","journal-title":"Pediatric Neurology"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib67","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1152\/physrev.00001.2017","article-title":"Endothelial cell metabolism","volume":"98","author":"Eelen","year":"2018","journal-title":"Physiological Reviews"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib68","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/cbf.937","article-title":"Age-related changes in the glutathione redox system","volume":"20","author":"Erden-Inal","year":"2002","journal-title":"Cell Biochemistry and Function"},{"issue":"17","key":"10.1016\/bs.irn.2023.08.004_bib69","doi-asserted-by":"crossref","first-page":"14088","DOI":"10.1074\/jbc.M111.305342","article-title":"Chronic expression of RCAN1\u20131L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells","volume":"287","author":"Ermak","year":"2012","journal-title":"The Journal of Biological Chemistry"},{"issue":"11","key":"10.1016\/bs.irn.2023.08.004_bib70","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/nrc1478","article-title":"Why do cancers have high aerobic glycolysis","volume":"4","author":"Gatenby","year":"2004","journal-title":"Nature Reviews. Cancer"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib71","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.trsl.2014.01.011","article-title":"Pericyte-endothelial crosstalk: Implications and opportunities for advanced cellular therapies","volume":"163","author":"Geevarghese","year":"2014","journal-title":"Translational Research: The Journal of Laboratory and Clinical Medicine"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib72","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/1097-0177(200007)218:3<472::AID-DVDY1008>3.0.CO;2-#","article-title":"N-cadherin mediates pericytic-endothelial interaction during brain angiogenesis in the chicken","volume":"218","author":"Gerhardt","year":"2000","journal-title":"Developmental Dynamics: An Official Publication of the American Association of Anatomists"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib73","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.stemcr.2014.02.002","article-title":"FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal","volume":"2","author":"Gopinath","year":"2014","journal-title":"Stem Cell Reports"},{"issue":"7","key":"10.1016\/bs.irn.2023.08.004_bib74","doi-asserted-by":"crossref","first-page":"672","DOI":"10.2174\/092986710790416263","article-title":"Inhibitors of lactate dehydrogenase isoforms and their therapeutic potentials","volume":"17","author":"Granchi","year":"2010","journal-title":"Current Medicinal Chemistry"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib75","doi-asserted-by":"crossref","first-page":"7404","DOI":"10.1096\/fj.202000283RR","article-title":"Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome","volume":"34","author":"Griffiths","year":"2020","journal-title":"The FASEB Journal"},{"issue":"10","key":"10.1016\/bs.irn.2023.08.004_bib76","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.162454","article-title":"KATP channels are necessary for glucose-dependent increases in amyloid-beta and Alzheimer\u2019s disease-related pathology","volume":"8","author":"Grizzanti","year":"2023","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib77","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.nbd.2012.06.007","article-title":"Oxidative burden and mitochondrial dysfunction in a mouse model of Rett syndrome","volume":"48","author":"Grosser","year":"2012","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/bs.irn.2023.08.004_bib78","doi-asserted-by":"crossref","first-page":"17065","DOI":"10.1038\/nrdp.2017.65","article-title":"Fragile X syndrome","volume":"3","author":"Hagerman","year":"2017","journal-title":"Nature Reviews Disease Primers"},{"issue":"7494","key":"10.1016\/bs.irn.2023.08.004_bib79","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature13165","article-title":"Capillary pericytes regulate cerebral blood flow in health and disease","volume":"508","author":"Hall","year":"2014","journal-title":"Nature"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib80","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1111\/j.1471-4159.2006.03907.x","article-title":"Oxidative stress and neurodegeneration: Where are we now?","volume":"97","author":"Halliwell","year":"2006","journal-title":"Journal of Neurochemistry"},{"issue":"6 Suppl","key":"10.1016\/bs.irn.2023.08.004_bib81","doi-asserted-by":"crossref","first-page":"1527S","DOI":"10.1093\/jn\/135.6.1527S","article-title":"Overview of the molecular and biochemical basis of branched-chain amino acid catabolism","volume":"135","author":"Harris","year":"2005","journal-title":"The Journal of Nutrition"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib82","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1152\/physrev.00049.2005","article-title":"Astrocyte control of synaptic transmission and neurovascular coupling","volume":"86","author":"Haydon","year":"2006","journal-title":"Physiological Reviews"},{"key":"10.1016\/bs.irn.2023.08.004_bib83","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2018.160","article-title":"Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types","volume":"5","author":"He","year":"2018","journal-title":"Scientific Data"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib84","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cmet.2012.12.005","article-title":"Adaptive downregulation of mitochondrial function in down syndrome","volume":"17","author":"Helguera","year":"2013","journal-title":"Cell Metabolism"},{"issue":"8","key":"10.1016\/bs.irn.2023.08.004_bib85","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/hipo.22958","article-title":"Modulation of hippocampal excitability via the hydroxycarboxylic acid receptor 1","volume":"28","author":"Herrera-Lopez","year":"2018","journal-title":"Hippocampus"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib86","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/ncb1881","article-title":"The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC\/C-Cdh1","volume":"11","author":"Herrero-Mendez","year":"2009","journal-title":"Nature Cell Biology"},{"issue":"27","key":"10.1016\/bs.irn.2023.08.004_bib87","doi-asserted-by":"crossref","first-page":"7079","DOI":"10.1523\/JNEUROSCI.1069-16.2016","article-title":"Selective deletion of astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to fragile X syndrome phenotypes in vivo","volume":"36","author":"Higashimori","year":"2016","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib88","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.bbrc.2018.03.077","article-title":"Mitochondrial dysfunction in dopaminergic neurons differentiated from exfoliated deciduous tooth-derived pulp stem cells of a child with Rett syndrome","volume":"498","author":"Hirofuji","year":"2018","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib89","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101183","article-title":"AUTS2 regulation of synapses for proper synaptic inputs and social communication","volume":"23","author":"Hori","year":"2020","journal-title":"iScience"},{"issue":"7","key":"10.1016\/bs.irn.2023.08.004_bib90","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1084\/jem.20151776","article-title":"Increased expression of AT-1\/SLC33A1 causes an autistic-like phenotype in mice by affecting dendritic branching and spine formation","volume":"213","author":"Hullinger","year":"2016","journal-title":"The Journal of Experimental Medicine"},{"issue":"8","key":"10.1016\/bs.irn.2023.08.004_bib91","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1089\/ars.2007.1674","article-title":"Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms","volume":"9","author":"Hunt","year":"2007","journal-title":"Antioxidants & Redox Signaling"},{"key":"10.1016\/bs.irn.2023.08.004_bib92","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nbd.2016.04.004","article-title":"Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability","volume":"93","author":"Inan","year":"2016","journal-title":"Neurobiology of Disease"},{"issue":"8","key":"10.1016\/bs.irn.2023.08.004_bib93","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1073\/pnas.0831078100","article-title":"Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo","volume":"100","author":"Itoh","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.irn.2023.08.004_bib94","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fncel.2014.00056","article-title":"The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves hypoxia tolerance in a mouse model of Rett syndrome","volume":"8","author":"Janc","year":"2014","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib95","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1042\/EBC20190041","article-title":"Metabolism","volume":"64","author":"Judge","year":"2020","journal-title":"Essays in Biochemistry"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib96","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1471-4159.2012.07936.x","article-title":"Early mitochondrial abnormalities in hippocampal neurons cultured from Fmr1 pre-mutation mouse model","volume":"123","author":"Kaplan","year":"2012","journal-title":"Journal of Neurochemistry"},{"key":"10.1016\/bs.irn.2023.08.004_bib97","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.71424","article-title":"Lactate is an energy substrate for rodent cortical neurons and enhances their firing activity","volume":"10","author":"Karagiannis","year":"2021","journal-title":"Elife"},{"issue":"10","key":"10.1016\/bs.irn.2023.08.004_bib98","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/cercor\/10.10.981","article-title":"Dendritic anomalies in disorders associated with mental retardation","volume":"10","author":"Kaufmann","year":"2000","journal-title":"Cerebral Cortex"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib99","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1023\/A:1007518525161","article-title":"Functional clarification of MCT1-mediated transport of monocarboxylic acids at the blood-brain barrier using in vitro cultured cells and in vivo BUI studies","volume":"17","author":"Kido","year":"2000","journal-title":"Pharmaceutical Research"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib100","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1172\/JCI110852","article-title":"Differential responsiveness to insulin of endothelial and support cells from micro- and macrovessels","volume":"71","author":"King","year":"1983","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.irn.2023.08.004_bib101","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0065-2571(72)90025-8","article-title":"Some aspects of the regulation of fuel supply in omnivorous animals","volume":"10","author":"Krebs","year":"1972","journal-title":"Advances in Enzyme Regulation"},{"issue":"13","key":"10.1016\/bs.irn.2023.08.004_bib102","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1128\/MCB.01665-05","article-title":"Gene expression analysis exposes mitochondrial abnormalities in a mouse model of Rett syndrome","volume":"26","author":"Kriaucionis","year":"2006","journal-title":"Molecular and Cellular Biology"},{"issue":"8","key":"10.1016\/bs.irn.2023.08.004_bib103","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201948882","article-title":"Mitochondrial protein biogenesis in the synapse is supported by local translation","volume":"21","author":"Kuzniewska","year":"2020","journal-title":"EMBO Reports"},{"issue":"5","key":"10.1016\/bs.irn.2023.08.004_bib104","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.neuron.2014.07.034","article-title":"Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex","volume":"83","author":"Lacoste","year":"2014","journal-title":"Neuron"},{"issue":"Pt 1","key":"10.1016\/bs.irn.2023.08.004_bib105","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.mod.2015.06.003","article-title":"Control of cerebrovascular patterning by neural activity during postnatal development","volume":"138","author":"Lacoste","year":"2015","journal-title":"Mechanisms of Development"},{"issue":"9","key":"10.1016\/bs.irn.2023.08.004_bib106","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.2174\/1568026614666140329230311","article-title":"Recent advances in delivery through the blood-brain barrier","volume":"14","author":"Larsen","year":"2014","journal-title":"Current Topics in Medicinal Chemistry"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib107","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jpeds.2005.10.037","article-title":"Rett syndrome in Australia: A review of the epidemiology","volume":"148","author":"Laurvick","year":"2006","journal-title":"The Journal of Pediatrics"},{"issue":"5","key":"10.1016\/bs.irn.2023.08.004_bib108","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1523\/JNEUROSCI.22-05-01523.2002","article-title":"Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: Elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism","volume":"22","author":"Lebon","year":"2002","journal-title":"The Journal of Neuroscience"},{"issue":"9","key":"10.1016\/bs.irn.2023.08.004_bib109","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2021109890","article-title":"Endothelium-derived lactate is required for pericyte function and blood-brain barrier maintenance","volume":"41","author":"Lee","year":"2022","journal-title":"The EMBO Journal"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib110","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrneurol.2016.186","article-title":"Clinical and biological progress over 50 years in Rett syndrome","volume":"13","author":"Leonard","year":"2017","journal-title":"Nature Reviews Neurology"},{"issue":"23","key":"10.1016\/bs.irn.2023.08.004_bib111","doi-asserted-by":"crossref","first-page":"9620","DOI":"10.1523\/JNEUROSCI.18-23-09620.1998","article-title":"Stoichiometry of the glial glutamate transporter GLT-1 expressed inducibly in a Chinese hamster ovary cell line selected for low endogenous Na+-dependent glutamate uptake","volume":"18","author":"Levy","year":"1998","journal-title":"The Journal of Neuroscience"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib112","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/0092-8674(92)90610-O","article-title":"Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA","volume":"69","author":"Lewis","year":"1992","journal-title":"Cell"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib113","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2019.08.011","article-title":"Hallmarks of endothelial cell metabolism in health and disease","volume":"30","author":"Li","year":"2019","journal-title":"Cell Metabolism"},{"key":"10.1016\/bs.irn.2023.08.004_bib114","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/bs.ctdb.2017.11.006","article-title":"Stem cells seen through the FOXO lens: An evolving paradigm","volume":"127","author":"Liang","year":"2018","journal-title":"Current Topics in Developmental Biology"},{"issue":"5","key":"10.1016\/bs.irn.2023.08.004_bib115","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.cell.2020.07.008","article-title":"ATP synthase c-subunit leak causes aberrant cellular metabolism in fragile X syndrome","volume":"182","author":"Licznerski","year":"2020","journal-title":"Cell"},{"key":"10.1016\/bs.irn.2023.08.004_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114298","article-title":"Auts2 regulated autism-like behavior, glucose metabolism and oxidative stress in mice","volume":"361","author":"Liu","year":"2023","journal-title":"Experimental Neurology"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib117","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.ygeno.2007.08.005","article-title":"Gene expression profiling in the adult Down syndrome brain","volume":"90","author":"Lockstone","year":"2007","journal-title":"Genomics"},{"key":"10.1016\/bs.irn.2023.08.004_bib118","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1146\/annurev-publhealth-031816-044318","article-title":"The changing epidemiology of autism spectrum disorders","volume":"38","author":"Lyall","year":"2017","journal-title":"Annual Review of Public Health"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib119","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1113\/expphysiol.2010.053157","article-title":"Neuron-glia metabolic coupling and plasticity","volume":"96","author":"Magistretti","year":"2011","journal-title":"Experimental Physiology"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib120","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/cercor\/6.1.50","article-title":"Cellular bases of brain energy metabolism and their relevance to functional brain imaging: Evidence for a prominent role of astrocytes","volume":"6","author":"Magistretti","year":"1996","journal-title":"Cerebral Cortex"},{"key":"10.1016\/bs.irn.2023.08.004_bib121","first-page":"177","article-title":"Astrocytes couple synaptic activity to glucose utilization in the brain","volume":"14","author":"Magistretti","year":"1999","journal-title":"News in Physiological Sciences: an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib122","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0006-8993(01)02418-0","article-title":"Mechanisms of glucose transport at the blood-brain barrier: an in vitro study","volume":"904","author":"McAllister","year":"2001","journal-title":"Brain Research"},{"key":"10.1016\/bs.irn.2023.08.004_bib123","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/164_2021_494","article-title":"Brain endothelial cells: Metabolic flux and energy metabolism","volume":"273","author":"McDonald","year":"2022","journal-title":"Handbook of Experimental Pharmacology"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib124","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0292-20.2021","article-title":"Distinct basal metabolism in three mouse models of neurodevelopmental disorders","volume":"8","author":"Menzies","year":"2021","journal-title":"eNeuro"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib125","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.celrep.2018.06.033","article-title":"Aberrant calcium signaling in astrocytes inhibits neuronal excitability in a human Down syndrome stem cell model","volume":"24","author":"Mizuno","year":"2018","journal-title":"Cell Reports"},{"key":"10.1016\/bs.irn.2023.08.004_bib126","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13229-017-0121-4","article-title":"Environmental risk factors for autism: An evidence-based review of systematic reviews and meta-analyses","volume":"8","author":"Modabbernia","year":"2017","journal-title":"Molecular Autism"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib127","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/glia.440140107","article-title":"The human blood-brain barrier glucose transporter (GLUT1) is a glucose transporter of gray matter astrocytes","volume":"14","author":"Morgello","year":"1995","journal-title":"Glia"},{"key":"10.1016\/bs.irn.2023.08.004_bib128","doi-asserted-by":"crossref","first-page":"15557","DOI":"10.1038\/ncomms15557","article-title":"Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1","volume":"8","author":"Morland","year":"2017","journal-title":"Nature Communications"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib129","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/2040-2392-4-2","article-title":"Evidence of reactive oxygen species-mediated damage to mitochondrial DNA in children with typical autism","volume":"4","author":"Napoli","year":"2013","journal-title":"Molecular Autism"},{"key":"10.1016\/bs.irn.2023.08.004_bib130","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fnint.2020.00007","article-title":"Metabolic signatures differentiate Rett Syndrome from unaffected siblings","volume":"14","author":"Neul","year":"2020","journal-title":"Frontiers in Integrative Neuroscience"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib131","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrn2995","article-title":"Engaging neuroscience to advance translational research in brain barrier biology","volume":"12","author":"Neuwelt","year":"2011","journal-title":"Nature Reviews. Neuroscience"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib132","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1177\/0271678X15606456","article-title":"Detrimental role of pericyte Nox4 in the acute phase of brain ischemia","volume":"36","author":"Nishimura","year":"2016","journal-title":"Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"6105","key":"10.1016\/bs.irn.2023.08.004_bib133","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1126\/science.1224631","article-title":"Mutations in BCKD-kinase lead to a potentially treatable form of autism with epilepsy","volume":"338","author":"Novarino","year":"2012","journal-title":"Science (New York, N. Y.)"},{"issue":"5","key":"10.1016\/bs.irn.2023.08.004_bib134","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/ana.410010502","article-title":"The large apparent work capability of the blood-brain barrier: A study of the mitochondrial content of capillary endothelial cells in brain and other tissues of the rat","volume":"1","author":"Oldendorf","year":"1977","journal-title":"Annals of Neurology"},{"key":"10.1016\/bs.irn.2023.08.004_bib135","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuropharm.2018.08.025","article-title":"Developmental role of adenosine kinase for the expression of sex-dependent neuropsychiatric behavior","volume":"141","author":"Osborne","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/bs.irn.2023.08.004_bib136","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.749026","article-title":"From neurodevelopmental to neurodegenerative disorders: The vascular continuum","volume":"13","author":"Ouellette","year":"2021","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"9","key":"10.1016\/bs.irn.2023.08.004_bib137","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1038\/s41593-020-0663-1","article-title":"Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice","volume":"23","author":"Ouellette","year":"2020","journal-title":"Nature Neuroscience"},{"key":"10.1016\/bs.irn.2023.08.004_bib138","doi-asserted-by":"crossref","first-page":"103474","DOI":"10.1016\/j.ebiom.2021.103474","article-title":"Energy metabolism in childhood neurodevelopmental disorders","volume":"69","author":"Oyarzabal","year":"2021","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib139","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1007\/s12035-015-9672-6","article-title":"Glucose transporters at the blood-brain barrier: Function, regulation and gateways for drug delivery","volume":"54","author":"Patching","year":"2017","journal-title":"Molecular Neurobiology"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib140","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.bbamcr.2012.12.004","article-title":"Lysine acetylation in the lumen of the ER: A novel and essential function under the control of the UPR","volume":"1833","author":"Pehar","year":"2013","journal-title":"Biochimica et Biophysica Acta"},{"issue":"Suppl 3","key":"10.1016\/bs.irn.2023.08.004_bib141","doi-asserted-by":"crossref","first-page":"S59","DOI":"10.1016\/S1262-3636(10)70469-9","article-title":"Food for thought: The importance of glucose and other energy substrates for sustaining brain function under varying levels of activity","volume":"36","author":"Pellerin","year":"2010","journal-title":"Diabetes & Metabolism"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib142","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/1073858403260159","article-title":"Neuroenergetics: Calling upon astrocytes to satisfy hungry neurons","volume":"10","author":"Pellerin","year":"2004","journal-title":"The Neuroscientist: A Review Journal Bringing Neurobiology, Neurology and Psychiatry"},{"issue":"7","key":"10.1016\/bs.irn.2023.08.004_bib143","doi-asserted-by":"crossref","first-page":"3990","DOI":"10.1073\/pnas.95.7.3990","article-title":"Expression of monocarboxylate transporter mRNAs in mouse brain: Support for a distinct role of lactate as an energy substrate for the neonatal vs. adult brain","volume":"95","author":"Pellerin","year":"1998","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7112","key":"10.1016\/bs.irn.2023.08.004_bib144","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nature05193","article-title":"Bidirectional control of CNS capillary diameter by pericytes","volume":"443","author":"Peppiatt","year":"2006","journal-title":"Nature"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib145","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/jnr.20272","article-title":"Antioxidants are required during the early critical period, but not later, for neuronal survival","volume":"78","author":"Perry","year":"2004","journal-title":"Journal of Neuroscience Research"},{"issue":"12","key":"10.1016\/bs.irn.2023.08.004_bib146","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1002\/glia.24080","article-title":"Urokinase plasminogen activator mediates changes in human astrocytes modeling fragile X syndrome","volume":"69","author":"Peteri","year":"2021","journal-title":"Glia"},{"key":"10.1016\/bs.irn.2023.08.004_bib147","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1146\/annurev.bi.57.070188.003543","article-title":"Hormonal regulation of hepatic gluconeogenesis and glycolysis","volume":"57","author":"Pilkis","year":"1988","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/bs.irn.2023.08.004_bib148","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1146\/annurev.ph.54.030192.004321","article-title":"Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis","volume":"54","author":"Pilkis","year":"1992","journal-title":"Annual Review of Physiology"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib149","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1179\/016164106X130371","article-title":"Effects of acidosis on brain capillary endothelial cells and cholinergic neurons: Relevance to vascular dementia and Alzheimer\u2019s disease","volume":"28","author":"Pirchl","year":"2006","journal-title":"Neurological Research"},{"key":"10.1016\/bs.irn.2023.08.004_bib150","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.702685","article-title":"Astrocytes in Down syndrome across the lifespan","volume":"15","author":"Ponroy Bally","year":"2021","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib151","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/glia.20589","article-title":"Na(+)-Ca(2+) cosignaling in the stimulation of the glucose transporter GLUT1 in cultured astrocytes","volume":"56","author":"Porras","year":"2008","journal-title":"Glia"},{"issue":"7","key":"10.1016\/bs.irn.2023.08.004_bib152","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/s42255-020-0243-4","article-title":"Lactate: The ugly duckling of energy metabolism","volume":"2","author":"Rabinowitz","year":"2020","journal-title":"Nature Metabolism"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib153","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1158\/0008-5472.CAN-12-2460","article-title":"Proliferation-independent control of tumor glycolysis by PDGFR-mediated AKT activation","volume":"73","author":"Ran","year":"2013","journal-title":"Cancer Research"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib154","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1083\/jcb.34.1.207","article-title":"Fine structural localization of a blood-brain barrier to exogenous peroxidase","volume":"34","author":"Reese","year":"1967","journal-title":"The Journal of Cell Biology"},{"issue":"8","key":"10.1016\/bs.irn.2023.08.004_bib155","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0196-0644(85)80055-X","article-title":"Brain acidosis","volume":"14","author":"Rehncrona","year":"1985","journal-title":"Annals of Emergency Medicine"},{"issue":"7","key":"10.1016\/bs.irn.2023.08.004_bib156","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1002\/glia.23997","article-title":"Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome","volume":"69","author":"Reynolds","year":"2021","journal-title":"Glia"},{"key":"10.1016\/bs.irn.2023.08.004_bib157","first-page":"521","article-title":"Depression as a glial-based synaptic dysfunction","volume":"9","author":"Rial","year":"2015","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"15","key":"10.1016\/bs.irn.2023.08.004_bib158","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1161\/CIRCULATIONAHA.113.007469","article-title":"Increased pericyte coverage mediated by endothelial-derived fibroblast growth factor-2 and interleukin-6 is a source of smooth muscle-like cells in pulmonary hypertension","volume":"129","author":"Ricard","year":"2014","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib159","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1096\/fj.201601004R","article-title":"Mitochondrial and redox abnormalities in autism lymphoblastoid cells: a sibling control study","volume":"31","author":"Rose","year":"2017","journal-title":"The FASEB Journal"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib160","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2014.15","article-title":"Oxidative stress induces mitochondrial dysfunction in a subset of autistic lymphoblastoid cell lines","volume":"4","author":"Rose","year":"2014","journal-title":"Translational Psychiatry"},{"issue":"6501","key":"10.1016\/bs.irn.2023.08.004_bib161","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/372055a0","article-title":"Mechanisms of intracellular protein transport","volume":"372","author":"Rothman","year":"1994","journal-title":"Nature"},{"issue":"29","key":"10.1016\/bs.irn.2023.08.004_bib162","doi-asserted-by":"crossref","first-page":"21161","DOI":"10.1074\/jbc.M113.474619","article-title":"Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase\/Akt and promote angiogenesis","volume":"288","author":"Ruan","year":"2013","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/bs.irn.2023.08.004_bib163","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1038\/ncomms3932","article-title":"Pericyte loss influences Alzheimer-like neurodegeneration in mice","volume":"4","author":"Sagare","year":"2013","journal-title":"Nature Communications"},{"issue":"5407","key":"10.1016\/bs.irn.2023.08.004_bib164","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.283.5407.1488","article-title":"Oxidative phosphorylation at the fin de siecle","volume":"283","author":"Saraste","year":"1999","journal-title":"Science (New York, N. Y.)"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib165","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1074\/jbc.M114.581892","article-title":"Functional characterization of 5-oxoproline transport via SLC16A1\/MCT1","volume":"290","author":"Sasaki","year":"2015","journal-title":"The Journal of Biological Chemistry"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib166","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0891-5849(99)00226-9","article-title":"Increased mitochondrial superoxide generation in neurons from trisomy 16 mice: A model of Down\u2019s syndrome","volume":"28","author":"Schuchmann","year":"2000","journal-title":"Free Radical Biology & Medicine"},{"issue":"18","key":"10.1016\/bs.irn.2023.08.004_bib167","doi-asserted-by":"crossref","first-page":"7216","DOI":"10.1523\/JNEUROSCI.18-18-07216.1998","article-title":"Altered Ca2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: A model of Down\u2019s syndrome","volume":"18","author":"Schuchmann","year":"1998","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/bs.irn.2023.08.004_bib168","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2021.100971","article-title":"Intermittent fasting and cognitive performance - Targeting BDNF as potential strategy to optimise brain health","volume":"65","author":"Seidler","year":"2022","journal-title":"Frontiers in Neuroendocrinology"},{"issue":"1\u20132","key":"10.1016\/bs.irn.2023.08.004_bib169","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/jnr.20277","article-title":"Ex vivo NMR study of lactate metabolism in rat brain under various depressed states","volume":"79","author":"Serres","year":"2005","journal-title":"Journal of Neuroscience Research"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib170","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41593-019-0338-y","article-title":"Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice","volume":"22","author":"Shen","year":"2019","journal-title":"Nature Neuroscience"},{"issue":"18","key":"10.1016\/bs.irn.2023.08.004_bib171","doi-asserted-by":"crossref","first-page":"2752","DOI":"10.1093\/hmg\/ddl211","article-title":"Mitochondrial dysfunction and tau hyperphosphorylation in Ts1Cje, a mouse model for Down syndrome","volume":"15","author":"Shukkur","year":"2006","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/bs.irn.2023.08.004_bib172","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annual Review of Biochemistry"},{"issue":"10","key":"10.1016\/bs.irn.2023.08.004_bib173","doi-asserted-by":"crossref","first-page":"7113","DOI":"10.1007\/s12035-019-1585-3","article-title":"Transcriptome and proteome profiling of neural induced pluripotent stem cells from individuals with Down syndrome disclose dynamic dysregulations of key pathways and cellular functions","volume":"56","author":"Sobol","year":"2019","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/bs.irn.2023.08.004_bib174","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fnins.2017.00288","article-title":"How energy metabolism supports cerebral function: Insights from (13)C magnetic resonance studies in vivo","volume":"11","author":"Sonnay","year":"2017","journal-title":"Frontiers in Neuroscience"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib175","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033418","article-title":"Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis","volume":"7","author":"Sonveaux","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib176","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020524","article-title":"Ingested ketone ester leads to a rapid rise of acetyl-CoA and competes with glucose metabolism in the brain of non-fasted mice","volume":"22","author":"Suissa","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib177","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1006\/geno.2002.6810","article-title":"Identification of a novel gene on chromosome 7q11.2 interrupted by a translocation breakpoint in a pair of autistic twins","volume":"80","author":"Sultana","year":"2002","journal-title":"Genomics"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib178","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111942","article-title":"Mutations in the transcriptional regulator MeCP2 severely impact key cellular and molecular signatures of human astrocytes during maturation","volume":"42","author":"Sun","year":"2023","journal-title":"Cell Reports"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib179","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/ajcn\/68.1.72","article-title":"A molecular model of human branched-chain amino acid metabolism","volume":"68","author":"Suryawan","year":"1998","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/bs.irn.2023.08.004_bib180","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.nbd.2013.01.006","article-title":"Mitochondrial abnormalities in temporal lobe of autistic brain","volume":"54","author":"Tang","year":"2013","journal-title":"Neurobiology of Disease"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib181","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.cell.2016.11.013","article-title":"Impaired amino acid transport at the blood brain barrier is a cause of autism spectrum disorder","volume":"167","author":"Tarlungeanu","year":"2016","journal-title":"Cell"},{"issue":"5","key":"10.1016\/bs.irn.2023.08.004_bib182","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/j.1471-4159.1987.tb05677.x","article-title":"Enzymatic protection against peroxidative damage in isolated brain capillaries","volume":"48","author":"Tayarani","year":"1987","journal-title":"Journal of Neurochemistry"},{"issue":"10","key":"10.1016\/bs.irn.2023.08.004_bib183","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1007\/s00213-019-05280-6","article-title":"Beyond the brain: A multi-system inflammatory subtype of autism spectrum disorder","volume":"236","author":"Thom","year":"2019","journal-title":"Psychopharmacology (Berl)"},{"issue":"1\u20132","key":"10.1016\/bs.irn.2023.08.004_bib184","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.bbamem.2003.11.012","article-title":"Metabolism and function of coenzyme Q","volume":"1660","author":"Turunen","year":"2004","journal-title":"Biochimica et Biophysica Acta"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib185","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.bbadis.2016.03.003","article-title":"The polyphenols resveratrol and epigallocatechin-3-gallate restore the severe impairment of mitochondria in hippocampal progenitor cells from a Down syndrome mouse model","volume":"1862","author":"Valenti","year":"2016","journal-title":"Biochimica et Biophysica Acta"},{"issue":"12","key":"10.1016\/bs.irn.2023.08.004_bib186","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1016\/j.bbadis.2017.09.014","article-title":"Inhibition of Drp1-mediated mitochondrial fission improves mitochondrial dynamics and bioenergetics stimulating neurogenesis in hippocampal progenitor cells from a Down syndrome mouse model","volume":"1863","author":"Valenti","year":"2017","journal-title":"Biochimica et Biophysica Acta - Molecular Basis of Disease"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib187","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/jcbfm.2009.35","article-title":"Blood lactate is an important energy source for the human brain","volume":"29","author":"van Hall","year":"2009","journal-title":"Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/bs.irn.2023.08.004_bib188","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105036","article-title":"Astrocyte-mediated disruption of ROS homeostasis in Fragile X mouse model","volume":"146","author":"Vandenberg","year":"2021","journal-title":"Neurochemistry International"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib189","first-page":"C125","article-title":"Mitochondrial bioenergetics of astrocytes in Fragile X syndrome: New perspectives on culture conditions and sex effects","volume":"322","author":"Vandenberg","year":"2022","journal-title":"American Journal of"},{"issue":"7693","key":"10.1016\/bs.irn.2023.08.004_bib190","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature25739","article-title":"A molecular atlas of cell types and zonation in the brain vasculature","volume":"554","author":"Vanlandewijck","year":"2018","journal-title":"Nature"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib191","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1053\/sp.2000.6361","article-title":"Glucose metabolism in the developing brain","volume":"24","author":"Vannucci","year":"2000","journal-title":"Seminars in Perinatology"},{"key":"10.1016\/bs.irn.2023.08.004_bib192","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jns.2016.03.026","article-title":"Autism spectrum disorders: Integration of the genome, transcriptome and the environment","volume":"364","author":"Vijayakumar","year":"2016","journal-title":"Journal of the Neurological Sciences"},{"issue":"8","key":"10.1016\/bs.irn.2023.08.004_bib193","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nrn1722","article-title":"Astrocytes, from brain glue to communication elements: The revolution continues","volume":"6","author":"Volterra","year":"2005","journal-title":"Nature Reviews. Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib194","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mito.2009.09.006","article-title":"Energetics, epigenetics, mitochondrial genetics","volume":"10","author":"Wallace","year":"2010","journal-title":"Mitochondrion"},{"issue":"6","key":"10.1016\/bs.irn.2023.08.004_bib195","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.stem.2019.09.009","article-title":"Brain endothelial cells maintain lactate homeostasis and control adult hippocampal neurogenesis","volume":"25","author":"Wang","year":"2019","journal-title":"Cell Stem Cell"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib196","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1038\/s41467-021-23843-0","article-title":"Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice","volume":"12","author":"Wang","year":"2021","journal-title":"Nature Communications"},{"key":"10.1016\/bs.irn.2023.08.004_bib197","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3389\/fnmol.2018.00216","article-title":"Brain energy and oxygen metabolism: Emerging role in normal function and disease","volume":"11","author":"Watts","year":"2018","journal-title":"Frontiers in Molecular Neuroscience"},{"issue":"7483","key":"10.1016\/bs.irn.2023.08.004_bib198","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nature12821","article-title":"Perturbed neural activity disrupts cerebral angiogenesis during a postnatal critical period","volume":"505","author":"Whiteus","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib199","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/0271678X20904687","article-title":"Tight junctions in the blood-brain barrier promote edema formation and infarct size in stroke - Ambivalent effects of sealing proteins","volume":"41","author":"Winkler","year":"2021","journal-title":"Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib200","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1089\/ars.2017.7216","article-title":"NAD(H) and NADP(H) redox couples and cellular energy metabolism","volume":"28","author":"Xiao","year":"2018","journal-title":"Antioxidants & Redox Signaling"},{"issue":"4","key":"10.1016\/bs.irn.2023.08.004_bib201","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1159\/000479401","article-title":"PDGF promotes the Warburg effect in pulmonary arterial smooth muscle cells via activation of the PI3K\/AKT\/mTOR\/HIF-1alpha signaling pathway","volume":"42","author":"Xiao","year":"2017","journal-title":"Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology"},{"issue":"10","key":"10.1016\/bs.irn.2023.08.004_bib202","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102123","article-title":"NADPH oxidase-related pathophysiology in experimental models of stroke","volume":"18","author":"Yao","year":"2017","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"10.1016\/bs.irn.2023.08.004_bib203","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1023\/A:1020595108560","article-title":"Crystal structure of bovine heart cytochrome c oxidase at 2.8 A resolution","volume":"30","author":"Yoshikawa","year":"1998","journal-title":"Journal of Bioenergetics and Biomembranes"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib204","first-page":"109","article-title":"Astroglia disturbances during development of the central nervous system in fetuses with Down's syndrome","volume":"49","author":"Zdaniuk","year":"2011","journal-title":"Folia Neuropathologica\/Association of Polish Neuropathologists and Medical Research Centre, Polish Academy of Sciences"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib205","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/hmg\/ddq491","article-title":"Tsc2 gene inactivation causes a more severe epilepsy phenotype than Tsc1 inactivation in a mouse model of tuberous sclerosis complex","volume":"20","author":"Zeng","year":"2011","journal-title":"Human Molecular Genetics"},{"issue":"6601","key":"10.1016\/bs.irn.2023.08.004_bib206","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/383634a0","article-title":"Flux coupling in a neuronal glutamate transporter","volume":"383","author":"Zerangue","year":"1996","journal-title":"Nature"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib207","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1038\/mp.2009.51","article-title":"Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders","volume":"15","author":"Zhao","year":"2010","journal-title":"Molecular Psychiatry"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib208","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.neuron.2008.01.003","article-title":"The blood-brain barrier in health and chronic neurodegenerative disorders","volume":"57","author":"Zlokovic","year":"2008","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/bs.irn.2023.08.004_bib209","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s13311-023-01360-w","article-title":"Memantine\/aripiprazole combination alleviates cognitive dysfunction in valproic acid rat model of autism: Hippocampal CREB\/BDNF signaling and glutamate homeostasis","volume":"20","author":"Zohny","year":"2023","journal-title":"Neurotherapeutics: The Journal of the American Society for Experimental NeuroTherapeutics"},{"issue":"3","key":"10.1016\/bs.irn.2023.08.004_bib210","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00406-004-0456-7","article-title":"Increased oxidative stress and altered activities of erythrocyte free radical scavenging enzymes in autism","volume":"254","author":"Zoroglu","year":"2004","journal-title":"European Archives of Psychiatry and Clinical Neuroscience"}],"container-title":["International Review of Neurobiology","Fragile X and Related Autism Spectrum Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774223000818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774223000818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T19:52:10Z","timestamp":1701287530000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0074774223000818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"ISBN":["9780443137297"],"references-count":210,"URL":"https:\/\/doi.org\/10.1016\/bs.irn.2023.08.004","relation":{},"ISSN":["0074-7742"],"issn-type":[{"value":"0074-7742","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]}}}