{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T06:21:49Z","timestamp":1782627709714,"version":"3.54.5"},"reference-count":135,"publisher":"Elsevier","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/bs.irn.2025.04.023","type":"book-chapter","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T19:20:13Z","timestamp":1747077613000},"source":"Crossref","is-referenced-by-count":1,"title":["Thymic physiology and pathophysiology in Myasthenia Gravis"],"prefix":"10.1016","author":[{"given":"Nadine","family":"Dragin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rozen","family":"Le Panse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/bs.irn.2025.04.023_bib1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.immuni.2006.01.003","article-title":"B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization","volume":"24","author":"Angeli","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/bs.irn.2025.04.023_bib2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/ni1444","article-title":"Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells","volume":"8","author":"Aschenbrenner","year":"2007","journal-title":"Nature Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib3","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1182\/blood-2003-11-3900","article-title":"Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis","volume":"105","author":"Balandina","year":"2005","journal-title":"Blood"},{"key":"10.1016\/bs.irn.2025.04.023_bib4","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20230896","article-title":"Adjusting to self in the thymus: CD4 versus CD8 lineage commitment and regulatory T cell development","volume":"221","author":"Baldwin","year":"2024","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/bs.irn.2025.04.023_bib5","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/s41467-021-21346-6","article-title":"Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla","volume":"12","author":"Bautista","year":"2021","journal-title":"Nature Communications"},{"key":"10.1016\/bs.irn.2025.04.023_bib6","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.jaut.2013.12.011","article-title":"Myasthenia gravis: A comprehensive review of immune dysregulation and etiological mechanisms","volume":"52","author":"Berrih-Aknin","year":"2014","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/bs.irn.2025.04.023_bib7","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1749-6632.1987.tb51282.x","article-title":"The role of the thymus in myasthenia gravis: immunohistological and immunological studies in 115 cases","volume":"505","author":"Berrih-Aknin","year":"1987","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/bs.irn.2025.04.023_bib8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/ana.21628","article-title":"CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia","volume":"66","author":"Berrih-Aknin","year":"2009","journal-title":"Annals of Neurology"},{"key":"10.1016\/bs.irn.2025.04.023_bib9","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nri1331","article-title":"Developing a new paradigm for thymus organogenesis","volume":"4","author":"Blackburn","year":"2004","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib10","first-page":"462","article-title":"Microenvironments in the normal thymus and the thymus in myasthenia gravis","volume":"119","author":"Bofill","year":"1985","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/bs.irn.2025.04.023_bib11","doi-asserted-by":"crossref","first-page":"95432","DOI":"10.18632\/oncotarget.20731","article-title":"Epstein-Barr virus in tumor-infiltrating B cells of myasthenia gravis thymoma: An innocent bystander or an autoimmunity mediator?","volume":"8","author":"Cavalcante","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/bs.irn.2025.04.023_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00809","article-title":"CD4+ T cells of myasthenia gravis patients are characterized by increased IL-21, IL-4, and IL-17A productions and higher presence of PD-1 and ICOS","volume":"11","author":"\u00c7ebi","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.exger.2017.12.022","article-title":"Thymic stromal cells: Roles in atrophy and age-associated dysfunction of the thymus","volume":"105","author":"Cepeda","year":"2018","journal-title":"Experimental Gerontology"},{"key":"10.1016\/bs.irn.2025.04.023_bib14","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/imr.12418","article-title":"Thymus: The next (re)generation","volume":"271","author":"Chaudhry","year":"2016","journal-title":"Immunological Reviews"},{"key":"10.1016\/bs.irn.2025.04.023_bib15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.molimm.2021.02.011","article-title":"Imbalance of Th17 and Tregs in thymoma may be a pathological mechanism of myasthenia gravis","volume":"133","author":"Chen","year":"2021","journal-title":"Molecular Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/imr.12646","article-title":"TCR tuning of T cell subsets","volume":"283","author":"Cho","year":"2018","journal-title":"Immunological Reviews"},{"key":"10.1016\/bs.irn.2025.04.023_bib17","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jaut.2013.12.013","article-title":"Innate immunity in myasthenia gravis thymus: Pathogenic effects of Toll-like receptor 4 signaling on autoimmunity","volume":"52","author":"Cordiglieri","year":"2014","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/bs.irn.2025.04.023_bib18","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jaut.2013.12.016","article-title":"Central role of interferon-beta in thymic events leading to myasthenia gravis","volume":"52","author":"Cufi","year":"2014","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/bs.irn.2025.04.023_bib19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/ana.23791","article-title":"Implication of double-stranded RNA signaling in the etiology of autoimmune myasthenia gravis","volume":"73","author":"Cufi","year":"2013","journal-title":"Annals of Neurology"},{"key":"10.1016\/bs.irn.2025.04.023_bib20","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jaut.2013.12.018","article-title":"Thymoma-associated myasthenia gravis: On the search for a pathogen signature","volume":"52","author":"Cufi","year":"2014","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/bs.irn.2025.04.023_bib21","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/imr.13306","article-title":"Primary and secondary defects of the thymus","volume":"322","author":"Dinges","year":"2024","journal-title":"Immunological Reviews"},{"key":"10.1016\/bs.irn.2025.04.023_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.706244","article-title":"Thymus degeneration and regeneration","volume":"12","author":"Duah","year":"2021","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib23","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1182\/blood.2020006779","article-title":"A wave of bipotent T\/ILC-restricted progenitors shapes the embryonic thymus microenvironment in a time-dependent manner","volume":"137","author":"Elsaid","year":"2021","journal-title":"Blood"},{"key":"10.1016\/bs.irn.2025.04.023_bib24","doi-asserted-by":"crossref","first-page":"2773","DOI":"10.4049\/jimmunol.171.6.2773","article-title":"Cutting edge: A possible role for CD4+ thymic macrophages as professional scavengers of apoptotic thymocytes","volume":"171","author":"Esashi","year":"2003","journal-title":"Journal of Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib25","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1242\/dev.087320","article-title":"Dynamics of thymus organogenesis and colonization in early human development","volume":"140","author":"Farley","year":"2013","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/bs.irn.2025.04.023_bib26","doi-asserted-by":"crossref","first-page":"5324","DOI":"10.4049\/jimmunol.174.9.5324","article-title":"Overexpression of IFN-induced protein 10 and its receptor CXCR3 in myasthenia gravis","volume":"174","author":"Feferman","year":"2005","journal-title":"Journal of Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib27","doi-asserted-by":"crossref","DOI":"10.1093\/ejcts\/ezs663","article-title":"Thymoma and the increased risk of developing extrathymic malignancies: A multicentre study","author":"Filosso","year":"2013","journal-title":"European Journal of Cardio-Thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery"},{"key":"10.1016\/bs.irn.2025.04.023_bib28","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1053\/hupa.2001.27106","article-title":"B cells in epithelial and perivascular compartments of human adult thymus","volume":"32","author":"Flores","year":"2001","journal-title":"Human Pathology"},{"key":"10.1016\/bs.irn.2025.04.023_bib29","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ygcen.2017.03.011","article-title":"Thymus: Conservation in evolution","volume":"246","author":"Franchini","year":"2017","journal-title":"General and Comparative Endocrinology"},{"key":"10.1016\/bs.irn.2025.04.023_bib30","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1146\/annurev-cellbio-111315-125324","article-title":"TCR signal strength and T cell development","volume":"32","author":"Gascoigne","year":"2016","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"10.1016\/bs.irn.2025.04.023_bib31","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1242\/dev.059998","article-title":"Mechanisms of thymus organogenesis and morphogenesis","volume":"138","author":"Gordon","year":"2011","journal-title":"Development (Cambridge, England)"},{"key":"10.1016\/bs.irn.2025.04.023_bib32","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1365-2249.1991.tb05625.x","article-title":"Individual germinal centres of myasthenia gravis human thymuses contain polyclonal activated B cells that express all the Vh and Vk families","volume":"83","author":"Guigou","year":"1991","journal-title":"Clinical and Experimental Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib33","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.52985","article-title":"Aire-dependent genes undergo Clp1-mediated 3\u2019UTR shortening associated with higher transcript stability in the thymus","volume":"9","author":"Guyon","year":"2020","journal-title":"Elife"},{"key":"10.1016\/bs.irn.2025.04.023_bib34","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/ni1438","article-title":"Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin","volume":"8","author":"Hamazaki","year":"2007","journal-title":"Nature Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib35","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.3389\/fimmu.2018.02120","article-title":"Comprehensively profiling the chromatin architecture of tissue restricted antigen expression in thymic epithelial cells over development","volume":"9","author":"Handel","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib36","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00401-021-02299-y","article-title":"Single-cell profiling of myasthenia gravis identifies a pathogenic T cell signature","volume":"141","author":"Ingelfinger","year":"2021","journal-title":"Acta Neuropathologica"},{"key":"10.1016\/bs.irn.2025.04.023_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.it.2019.01.011","article-title":"Rethinking thymic tolerance: Lessons from mice","author":"Inglesfield","year":"2019","journal-title":"Trends in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/intimm\/dxl129","article-title":"Expression of Dll4 and CCL25 in Foxn1-negative epithelial cells in the post-natal thymus","volume":"19","author":"Itoi","year":"2007","journal-title":"International Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib39","article-title":"Thymus-derived B cell clones persist in the circulation after thymectomy in myasthenia gravis","volume":"117","author":"Jiang","year":"2020","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.irn.2025.04.023_bib40","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41577-019-0238-0","article-title":"Thymic epithelial cell heterogeneity: TEC by TEC","volume":"20","author":"Kadouri","year":"2020","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.nmd.2016.10.012","article-title":"Analysis of TNF-related apoptosis-inducing ligand and receptors and implications in thymus biology and myasthenia gravis","volume":"27","author":"Kanatli","year":"2017","journal-title":"Neuromuscular Disorders: NMD"},{"key":"10.1016\/bs.irn.2025.04.023_bib42","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.clineuro.2007.08.006","article-title":"Effects of thymectomy on late-onset myasthenia gravis without thymoma","volume":"109","author":"Kawaguchi","year":"2007","journal-title":"Clinical Neurology and Neurosurgery"},{"key":"10.1016\/bs.irn.2025.04.023_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2008.07.008","article-title":"Regulation of autoimmune inflammation by pro-inflammatory cytokines","volume":"120","author":"Kim","year":"2008","journal-title":"Immunology Letters"},{"key":"10.1016\/bs.irn.2025.04.023_bib44","article-title":"Antigen presentation for central tolerance induction","author":"Klein","year":"2024","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib45","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.autrev.2018.07.011","article-title":"Characterization of the thymus in Lrp4 myasthenia gravis: Four cases","volume":"18","author":"Koneczny","year":"2019","journal-title":"Autoimmunity Reviews"},{"key":"10.1016\/bs.irn.2025.04.023_bib46","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1002\/eji.201646354","article-title":"Temporal increase in thymocyte negative selection parallels enhanced thymic SIRPalpha(+) DC function","volume":"46","author":"Kroger","year":"2016","journal-title":"European Journal of Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib47","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.immuni.2014.08.013","article-title":"Love Is in the Aire: mTECs share their assets","volume":"41","author":"Kyewski","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/bs.irn.2025.04.023_bib48","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/ni1323","article-title":"Thymic microenvironments for T cell differentiation and selection","volume":"7","author":"Ladi","year":"2006","journal-title":"Nature Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102337","article-title":"Risk factors associated with myasthenia gravis in thymoma patients: The potential role of thymic germinal centers","volume":"106","author":"Lefeuvre","year":"2020","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/bs.irn.2025.04.023_bib50","doi-asserted-by":"crossref","first-page":"893","DOI":"10.2353\/ajpath.2007.070240","article-title":"Myasthenia gravis thymus: Complement vulnerability of epithelial and myoid cells, complement attack on them, and correlations with autoantibody status","volume":"171","author":"Leite","year":"2007","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/bs.irn.2025.04.023_bib51","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1002\/ana.20386","article-title":"Fewer thymic changes in MuSK antibody-positive than in MuSK antibody-negative MG","volume":"57","author":"Leite","year":"2005","journal-title":"Annals of Neurology"},{"key":"10.1016\/bs.irn.2025.04.023_bib52","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.4049\/jimmunol.145.7.2115","article-title":"Thymic B cells from myasthenia gravis patients are activated B cells. Phenotypic and functional analysis","volume":"145","author":"Leprince","year":"1990","journal-title":"Journal of Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2023.101837","article-title":"Thymus aging and immune reconstitution, progresses and challenges","volume":"70","author":"Li","year":"2023","journal-title":"Seminars in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib54","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41392-023-01451-2","article-title":"Immunosenescence: Molecular mechanisms and diseases","volume":"8","author":"Liu","year":"2023","journal-title":"Signal Transduction and Targeted Therapy"},{"key":"10.1016\/bs.irn.2025.04.023_bib55","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/ni.2255","article-title":"The earliest thymic T cell progenitors sustain B cell and myeloid lineage potential","volume":"13","author":"Luc","year":"2012","journal-title":"Nature Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib56","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.it.2009.04.003","article-title":"Thymic involution and immune reconstitution","volume":"30","author":"Lynch","year":"2009","journal-title":"Trends in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib57","doi-asserted-by":"crossref","first-page":"S266","DOI":"10.1097\/JTO.0b013e3181f1f63f","article-title":"The autoimmune regulator AIRE in thymoma biology: Autoimmunity and beyond","volume":"5","author":"Marx","year":"2010","journal-title":"Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer"},{"key":"10.1016\/bs.irn.2025.04.023_bib58","doi-asserted-by":"crossref","first-page":"413","DOI":"10.3109\/08916930903555935","article-title":"Thymoma and paraneoplastic myasthenia gravis","volume":"43","author":"Marx","year":"2010","journal-title":"Autoimmunity"},{"key":"10.1016\/bs.irn.2025.04.023_bib59","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00281-021-00842-3","article-title":"Thymus and autoimmunity","volume":"43","author":"Marx","year":"2021","journal-title":"Seminars in Immunopathology"},{"key":"10.1016\/bs.irn.2025.04.023_bib60","first-page":"137","article-title":"Acetylcholine receptor antibody synthesis in lymphocyte cultures","volume":"5","author":"McLachlan","year":"1981","journal-title":"Journal of Clinical & Laboratory Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib61","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1172\/JCI113401","article-title":"Thymus in myasthenia gravis. Isolation of T-lymphocyte lines specific for the nicotinic acetylcholine receptor from thymuses of myasthenic patients","volume":"81","author":"Melms","year":"1988","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.irn.2025.04.023_bib62","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1182\/blood-2005-06-2383","article-title":"The chemokine CXCL13 is a key molecule in autoimmune myasthenia gravis","volume":"108","author":"M\u00e9raouna","year":"2006","journal-title":"Blood"},{"key":"10.1016\/bs.irn.2025.04.023_bib63","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.jneuroim.2003.11.013","article-title":"Thymic myoid cells express high levels of muscle genes","volume":"148","author":"Mesnard-Rouiller","year":"2004","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib64","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.celrep.2013.08.038","article-title":"Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population","volume":"5","author":"Metzger","year":"2013","journal-title":"Cell Reports"},{"key":"10.1016\/bs.irn.2025.04.023_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2022.05.018","article-title":"Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells","author":"Michelson","year":"2022","journal-title":"Cell"},{"key":"10.1016\/bs.irn.2025.04.023_bib66","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev-cellbio-112122-023316","article-title":"Thymic mimetic cells: Ontogeny as immunology","volume":"40","author":"Michelson","year":"2024","journal-title":"Annual Review of Cell and Developmental Biology"},{"key":"10.1016\/bs.irn.2025.04.023_bib67","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/s41586-018-0345-2","article-title":"Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development","volume":"559","author":"Miller","year":"2018","journal-title":"Nature"},{"key":"10.1016\/bs.irn.2025.04.023_bib68","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1182\/blood.V89.9.3287","article-title":"Thymocyte Fas expression is dysregulated in myasthenia gravis patients with anti-acetylcholine receptor antibody","volume":"89","author":"Moulian","year":"1997","journal-title":"Blood"},{"key":"10.1016\/bs.irn.2025.04.023_bib69","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/mus.10362","article-title":"Dendritic cells in hyperplastic thymuses from patients with myasthenia gravis","volume":"27","author":"Nagane","year":"2003","journal-title":"Muscle & Nerve"},{"key":"10.1016\/bs.irn.2025.04.023_bib70","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1212\/WNL.0000000000011124","article-title":"International consensus guidance for management of myasthenia gravis","volume":"96","author":"Narayanaswami","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/bs.irn.2025.04.023_bib71","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4049\/jimmunol.2100692","article-title":"Aire controls heterogeneity of medullary thymic epithelial cells for the expression of self-antigens","volume":"208","author":"Nishijima","year":"2022","journal-title":"Journal of Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib72","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s41232-022-00219-5","article-title":"Mesenchymal stromal cells in the thymus","volume":"42","author":"Nitta","year":"2022","journal-title":"Inflammation and Regeneration"},{"key":"10.1016\/bs.irn.2025.04.023_bib73","doi-asserted-by":"crossref","DOI":"10.15252\/embr.201540096","article-title":"The thymic cortical epithelium determines the TCR repertoire of IL-17-producing gammadeltaT cells","author":"Nitta","year":"2015","journal-title":"EMBO Reports"},{"key":"10.1016\/bs.irn.2025.04.023_bib74","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/imr.12985","article-title":"The fibroblast: An emerging key player in thymic T cell selection","volume":"302","author":"Nitta","year":"2021","journal-title":"Immunological Reviews"},{"key":"10.1016\/bs.irn.2025.04.023_bib75","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00018-015-2107-8","article-title":"Thymic stromal cell subsets for T cell development","volume":"73","author":"Nitta","year":"2016","journal-title":"Cellular and Molecular Life Sciences: CMLS"},{"key":"10.1016\/bs.irn.2025.04.023_bib76","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4110\/in.2015.15.3.111","article-title":"The role of dendritic cells in central tolerance","volume":"15","author":"Oh","year":"2015","journal-title":"Immune Network"},{"key":"10.1016\/bs.irn.2025.04.023_bib77","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20230892","article-title":"Rediscovering the human thymus through cutting-edge technologies","volume":"221","author":"Pala","year":"2024","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/bs.irn.2025.04.023_bib78","doi-asserted-by":"crossref","first-page":"316","DOI":"10.3389\/fimmu.2013.00316","article-title":"The effect of age on thymic function","volume":"4","author":"Palmer","year":"2013","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib79","doi-asserted-by":"crossref","first-page":"7868","DOI":"10.4049\/jimmunol.177.11.7868","article-title":"Microarrays reveal distinct gene signatures in the thymus of seropositive and seronegative myasthenia gravis patients and the role of CC chemokine ligand 21 in thymic hyperplasia","volume":"177","author":"Le Panse","year":"2006","journal-title":"Journal of Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib80","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay3224","article-title":"A cell atlas of human thymic development defines T cell repertoire formation","volume":"367","author":"Park","year":"2020","journal-title":"Science"},{"key":"10.1016\/bs.irn.2025.04.023_bib81","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/ana.26590","article-title":"Central role of macrophages and nucleic acid release in myasthenia gravis thymus","volume":"93","author":"Payet","year":"2023","journal-title":"Annals of Neurology"},{"key":"10.1016\/bs.irn.2025.04.023_bib82","doi-asserted-by":"crossref","first-page":"17011","DOI":"10.1073\/pnas.1313001110","article-title":"Autoreactive thymic B cells are efficient antigen-presenting cells of cognate self-antigens for T cell negative selection","volume":"110","author":"Perera","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.irn.2025.04.023_bib83","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.celrep.2016.09.011","article-title":"Self-antigen-driven thymic B cell class switching promotes T cell central tolerance","volume":"17","author":"Perera","year":"2016","journal-title":"Cell Reports"},{"key":"10.1016\/bs.irn.2025.04.023_bib84","doi-asserted-by":"crossref","first-page":"5941","DOI":"10.4049\/jimmunol.174.10.5941","article-title":"Effects of cytokines on acetylcholine receptor expression: Implications for myasthenia gravis","volume":"174","author":"Poea-Guyon","year":"2005","journal-title":"Journal of Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib85","doi-asserted-by":"crossref","DOI":"10.1016\/j.devcel.2023.08.017","article-title":"Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus","author":"Ragazzini","year":"2023","journal-title":"Developmental Cell"},{"key":"10.1016\/bs.irn.2025.04.023_bib86","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/ni.2782","article-title":"Two waves of distinct hematopoietic progenitor cells colonize the fetal thymus","volume":"15","author":"Ramond","year":"2014","journal-title":"Nature Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib87","doi-asserted-by":"crossref","first-page":"1108630","DOI":"10.3389\/fimmu.2023.1108630","article-title":"Intrathymic somatotropic circuitry: Consequences upon thymus involution","volume":"14","author":"Reis","year":"2023","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib88","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/352414","article-title":"The importance of the nurse cells and regulatory cells in the control of T lymphocyte responses","volume":"2013","author":"Reyes Garc\u00eda","year":"2013","journal-title":"BioMed Research International"},{"key":"10.1016\/bs.irn.2025.04.023_bib89","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/dvdy.20268","article-title":"Retinoic acid down-regulates Tbx1 expression in vivo and in vitro","volume":"232","author":"Roberts","year":"2005","journal-title":"Developmental Dynamics: an Official Publication of the American Association of Anatomists"},{"key":"10.1016\/bs.irn.2025.04.023_bib90","doi-asserted-by":"crossref","DOI":"10.4061\/2011\/474512","article-title":"Thymoma in myasthenia gravis: From diagnosis to treatment","author":"Romi","year":"2011","journal-title":"Autoimmune Diseases"},{"key":"10.1016\/bs.irn.2025.04.023_bib91","doi-asserted-by":"crossref","first-page":"1443910","DOI":"10.3389\/fimmu.2024.1443910","article-title":"The thymus road to a T cell: Migration, selection, and atrophy","volume":"15","author":"Ruiz","year":"2024","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib92","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1161\/CIRCRESAHA.109.205732","article-title":"Decreased levels of embryonic retinoic acid synthesis accelerate recovery from arterial growth delay in a mouse model of DiGeorge syndrome","volume":"106","author":"Ryckeb\u00fcsch","year":"2010","journal-title":"Circulation Research"},{"key":"10.1016\/bs.irn.2025.04.023_bib93","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/BF00915728","article-title":"In vitro anti-acetylcholine receptor antibody synthesis by myasthenia gravis patient lymphocytes: correlations with thymic histology and thymic epithelial-cell interactions","volume":"7","author":"Safar","year":"1987","journal-title":"Journal of Clinical Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib94","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.jneuroim.2005.09.001","article-title":"Altered expression of chemokine receptor CXCR5 on T cells of myasthenia gravis patients","volume":"170","author":"Saito","year":"2005","journal-title":"Journal of Neuroimmunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib95","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ensci.2016.02.004","article-title":"Late-onset myasthenia gravis is predisposed to become generalized in the elderly","volume":"2","author":"Sakai","year":"2016","journal-title":"eNeurologicalSci"},{"key":"10.1016\/bs.irn.2025.04.023_bib96","first-page":"21","article-title":"Increased bax\/bcl-2 ratio up-regulates caspase-3 and increases apoptosis in the thymus of patients with myasthenia gravis","author":"Salakou","year":"2007","journal-title":"In Vivo (Brooklyn)"},{"key":"10.1016\/bs.irn.2025.04.023_bib97","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1101\/gr.171645.113","article-title":"Population and single-cell genomics reveal the Aire dependency, relief from Polycomb silencing, and distribution of self-antigen expression in thymic epithelia","volume":"24","author":"Sansom","year":"2014","journal-title":"Genome Research"},{"issue":"1","key":"10.1016\/bs.irn.2025.04.023_bib98","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1017\/S0007114507832880","article-title":"The thymus is a common target in malnutrition and infection","volume":"98","author":"Savino","year":"2007","journal-title":"The British Journal of Nutrition"},{"key":"10.1016\/bs.irn.2025.04.023_bib99","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/imr.12694","article-title":"The natural history of naive T cells from birth to maturity","volume":"285","author":"Seddon","year":"2018","journal-title":"Immunological Reviews"},{"key":"10.1016\/bs.irn.2025.04.023_bib100","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20230893","article-title":"Transcriptional network dynamics in early T cell development","volume":"221","author":"Shin","year":"2024","journal-title":"The Journal of Experimental Medicine"},{"key":"10.1016\/bs.irn.2025.04.023_bib101","doi-asserted-by":"crossref","first-page":"6173","DOI":"10.4049\/jimmunol.1202573","article-title":"IL-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRgammadelta+ intraepithelial lymphocytes","volume":"190","author":"Shitara","year":"2013","journal-title":"Journal of Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib102","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/ana.410280303","article-title":"Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor\u2013reactive T cells","volume":"28","author":"Sommer","year":"1990","journal-title":"Annals of Neurology"},{"key":"10.1016\/bs.irn.2025.04.023_bib103","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/ana.20340","article-title":"Selective loss of regulatory T cells in thymomas","volume":"56","author":"Strobel","year":"2004","journal-title":"Annals of Neurology"},{"key":"10.1016\/bs.irn.2025.04.023_bib104","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.89665","article-title":"Preconditioned mesenchymal stem cells treat myasthenia gravis in a humanized preclinical model","volume":"2","author":"Sudres","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/bs.irn.2025.04.023_bib105","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/372100a0","article-title":"T-cell apoptosis detected in situ during positive and negative selection in the thymus","volume":"372","author":"Surh","year":"1994","journal-title":"Nature"},{"key":"10.1016\/bs.irn.2025.04.023_bib106","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1309\/CAV8RNU5TKNACKNC","article-title":"Thymoma classification: Current status and future trends","volume":"125","author":"Suster","year":"2006","journal-title":"American Journal of Clinical Pathology"},{"key":"10.1016\/bs.irn.2025.04.023_bib107","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nri1781","article-title":"Journey through the thymus: Stromal guides for T-cell development and selection","volume":"6","author":"Takahama","year":"2006","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib108","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.975858","article-title":"Effects of sex steroids on thymic epithelium and thymocyte development","volume":"13","author":"Taves","year":"2022","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib109","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.thorsurg.2018.12.001","article-title":"The role of the thymus in the immune response","volume":"29","author":"Thapa","year":"2019","journal-title":"Thoracic Surgery Clinics"},{"key":"10.1016\/bs.irn.2025.04.023_bib110","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s12979-020-0173-8","article-title":"Contributions of age-related thymic involution to immunosenescence and inflammaging","volume":"17","author":"Thomas","year":"2020","journal-title":"Immunity & Ageing: I & A"},{"key":"10.1016\/bs.irn.2025.04.023_bib111","doi-asserted-by":"crossref","first-page":"13955","DOI":"10.1038\/s41598-024-63162-0","article-title":"Comparison of juvenile and adult myasthenia gravis in a French cohort with focus on thymic histology","volume":"14","author":"Truffault","year":"2024","journal-title":"Scientific Reports"},{"key":"10.1016\/bs.irn.2025.04.023_bib112","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s12016-016-8558-3","article-title":"Thymic germinal centers and corticosteroids in myasthenia gravis: An immunopathological study in 1035 cases and a critical review","volume":"52","author":"Truffault","year":"2017","journal-title":"Clinical Reviews in Allergy & Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2020.00782","article-title":"Comparative analysis of thymic and blood treg in myasthenia gravis: Thymic epithelial cells contribute to thymic immunoregulatory defects","volume":"11","author":"Truffault","year":"2020","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib114","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1196\/annals.1443.018","article-title":"The thymus medulla slowly yields its secrets","volume":"1143","author":"Tykocinski","year":"2008","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/bs.irn.2025.04.023_bib115","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s00415-015-7673-z","article-title":"Two-year outcome of thymectomy in non-thymomatous late-onset myasthenia gravis","volume":"262","author":"Uzawa","year":"2015","journal-title":"Journal of Neurology"},{"key":"10.1016\/bs.irn.2025.04.023_bib116","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/jemt.10411","article-title":"Age-dependent changes in thymic macrophages and dendritic cells","volume":"62","author":"Varas","year":"2003","journal-title":"Microscopy Research and Technique"},{"key":"10.1016\/bs.irn.2025.04.023_bib117","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1083218","article-title":"Single-cell mass cytometry on peripheral cells in myasthenia gravis identifies dysregulation of innate immune cells","volume":"14","author":"Verdier","year":"2023","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib118","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jaut.2018.11.005","article-title":"Il-23\/Th17 cell pathway: A promising target to alleviate thymic inflammation maintenance in myasthenia gravis","volume":"98","author":"Villegas","year":"2019","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/bs.irn.2025.04.023_bib119","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.3389\/fimmu.2018.01663","article-title":"Cultured human thymic-derived cells display medullary thymic epithelial cell phenotype and functionality","volume":"9","author":"Villegas","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/0008-8749(86)90086-9","article-title":"The influence of dexamethasone treatment on the lymphoid and stromal composition of the mouse thymus: A flowcytometric and immunohistological analysis","volume":"103","author":"van Vliet","year":"1986","journal-title":"Cellular Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib121","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jaut.2013.12.008","article-title":"Clonal heterogeneity of thymic B cells from early-onset myasthenia gravis patients with antibodies against the acetylcholine receptor","volume":"52","author":"Vrolix","year":"2014","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/bs.irn.2025.04.023_bib122","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0002-9440(10)65225-X","article-title":"Establishment of a human thymic myoid cell line. Phenotypic and functional characteristics","volume":"155","author":"Wakkach","year":"1999","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/bs.irn.2025.04.023_bib123","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.3389\/fimmu.2019.03099","article-title":"Thymic epithelial cells contribute to thymopoiesis and T cell development","volume":"10","author":"Wang","year":"2019","journal-title":"Frontiers in Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib124","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.imbio.2012.05.006","article-title":"SDF-1\/CXCL12 recruits B cells and antigen-presenting cells to the thymus of autoimmune myasthenia gravis patients","volume":"218","author":"Weiss","year":"2013","journal-title":"Immunobiology"},{"key":"10.1016\/bs.irn.2025.04.023_bib125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1196\/annals.1405.021","article-title":"Autoimmunizing mechanisms in thymoma and thymus","volume":"1132","author":"Willcox","year":"2008","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/bs.irn.2025.04.023_bib126","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1056\/NEJMoa1602489","article-title":"Randomized trial of thymectomy in myasthenia gravis","volume":"375","author":"Wolfe","year":"2016","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/bs.irn.2025.04.023_bib127","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ni.3419","article-title":"Late stages of T cell maturation in the thymus involve NF-kappaB and tonic type I interferon signaling","volume":"17","author":"Xing","year":"2016","journal-title":"Nature Immunology"},{"key":"10.1016\/bs.irn.2025.04.023_bib128","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.immuni.2015.05.013","article-title":"Thymic B cells are licensed to present self antigens for central T cell tolerance induction","volume":"42","author":"Yamano","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/bs.irn.2025.04.023_bib129","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114677","article-title":"Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis-associated thymoma","volume":"43","author":"Yasumizu","year":"2024","journal-title":"Cell Reports"},{"key":"10.1016\/bs.irn.2025.04.023_bib130","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1038\/s41467-022-31951-8","article-title":"Myasthenia gravis-specific aberrant neuromuscular gene expression by medullary thymic epithelial cells in thymoma","volume":"13","author":"Yasumizu","year":"2022","journal-title":"Nature Communications"},{"key":"10.1016\/bs.irn.2025.04.023_bib131","article-title":"A spatial human thymus cell atlas mapped to a continuous tissue axis","author":"Yayon","year":"2023","journal-title":"bioRxiv"},{"key":"10.1016\/bs.irn.2025.04.023_bib132","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1007\/s12035-014-8985-1","article-title":"Intrathymic Tfh\/B cells interaction leads to ectopic GCs formation and anti-AChR antibody production: Central role in triggering MG occurrence","volume":"53","author":"Zhang","year":"2016","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/bs.irn.2025.04.023_bib133","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.75148","article-title":"Thymic macrophages consist of two populations with distinct localization and origin","volume":"11","author":"Zhou","year":"2022","journal-title":"Elife"},{"key":"10.1016\/bs.irn.2025.04.023_bib134","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.jaut.2013.12.004","article-title":"A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis","volume":"52","author":"Zisimopoulou","year":"2014","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/bs.irn.2025.04.023_fur1","doi-asserted-by":"crossref","DOI":"10.1016\/S1474-4422(18)30392-2","article-title":"Long-term effect of thymectomy plus prednisone versus prednisone alone in patients with non-thymomatous myasthenia gravis: 2-Year extension of the MGTX randomised trial","author":"Wolfe","year":"2019","journal-title":"Lancet Neurology"}],"container-title":["International Review of Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774225000388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774225000388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T19:20:31Z","timestamp":1747077631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0074774225000388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":135,"URL":"https:\/\/doi.org\/10.1016\/bs.irn.2025.04.023","relation":{},"ISSN":["0074-7742"],"issn-type":[{"value":"0074-7742","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}