{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:07:18Z","timestamp":1791284838908,"version":"4.1.0"},"reference-count":182,"publisher":"Elsevier","isbn-type":[{"value":"9780443344435","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.irn.2026.01.001","type":"book-chapter","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:40:51Z","timestamp":1769604051000},"page":"75-106","source":"Crossref","is-referenced-by-count":1,"title":["Glutamate-Glutamine metabolism and transport, implications in Parkinson\u2019s disease"],"prefix":"10.1016","author":[{"given":"Ragini","family":"Raghu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5468-2129","authenticated-orcid":false,"given":"Subashchandrabose","family":"Chinnathambi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0896-6273(00)80886-7","article-title":"Mice lacking \u03b1-synuclein display functional deficits in the nigrostriatal dopamine system","volume":"25","author":"Abeliovich","year":"2000","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/bs.irn.2026.01.001_bib2","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1007\/s11064-022-03771-1","article-title":"Glial glutamine homeostasis in health and disease","volume":"48","author":"Andersen","year":"2023","journal-title":"Neurochemical Research"},{"issue":"10","key":"10.1016\/bs.irn.2026.01.001_bib3","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1038\/s41418-020-0542-z","article-title":"Alpha synuclein aggregation drives ferroptosis: An interplay of iron, calcium and lipid peroxidation","volume":"27","author":"Angelova","year":"2020","journal-title":"Cell Death & Differentiation"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1460-9568.2007.05979.x","article-title":"Oxidative stress on EAAC1 is involved in MPTP-induced glutathione depletion and motor dysfunction","volume":"27","author":"Aoyama","year":"2008","journal-title":"European Journal of Neuroscience"},{"issue":"8","key":"10.1016\/bs.irn.2026.01.001_bib5","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1073\/pnas.94.8.4155","article-title":"Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride\u2009conductance","volume":"94","author":"Arriza","year":"1997","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"9","key":"10.1016\/bs.irn.2026.01.001_bib6","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.1523\/JNEUROSCI.14-09-05559.1994","article-title":"Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex","volume":"14","author":"Arriza","year":"1994","journal-title":"The Journal of Neuroscience"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib7","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1093\/cercor\/bhp133","article-title":"Vesicular glutamate transporter VGLUT1 Has a role in hippocampal long-term potentiation and spatial reversal learning","volume":"20","author":"Balschun","year":"2010","journal-title":"Cerebral Cortex"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib8","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.cell.2004.11.049","article-title":"Cleavage of the plasma membrane Na+\/Ca2+ exchanger in excitotoxicity","volume":"120","author":"Bano","year":"2005","journal-title":"Cell"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib9","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/ana.22162","article-title":"N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1\u2212\/\u2212 mouse","volume":"69","author":"Berman","year":"2011","journal-title":"Annals of Neurology"},{"issue":"8","key":"10.1016\/bs.irn.2026.01.001_bib10","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1111\/j.1476-5381.2012.01943.x","article-title":"Allosteric modulation of the group III mGlu4 receptor provides functional neuroprotection in the 6-hydroxydopamine rat model of Parkinson\u2019s disease","volume":"166","author":"Betts","year":"2012","journal-title":"British Journal of Pharmacology"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00401-015-1504-2","article-title":"Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes","volume":"131","author":"Bliederhaeuser","year":"2016","journal-title":"Acta Neuropathologica"},{"key":"10.1016\/bs.irn.2026.01.001_bib12","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.neuropharm.2005.05.012","article-title":"Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons","volume":"49","author":"Bonsi","year":"2005","journal-title":"Neuropharmacology"},{"key":"10.1016\/bs.irn.2026.01.001_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2023.103887","article-title":"Glutamine metabolism in diseases associated with mitochondrial dysfunction","volume":"126","author":"Bornstein","year":"2023","journal-title":"Molecular and Cellular Neuroscience"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib14","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0899-9007(01)00795-X","article-title":"Glutamine: An anaplerotic precursor","volume":"18","author":"Bowtell","year":"2002","journal-title":"Nutrition"},{"issue":"5","key":"10.1016\/bs.irn.2026.01.001_bib15","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13365","article-title":"Vesicular glutamate transporter modulates sex differences in dopamine neuron vulnerability to age-related neurodegeneration","volume":"20","author":"Buck","year":"2021","journal-title":"Aging Cell"},{"issue":"5999","key":"10.1016\/bs.irn.2026.01.001_bib16","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1126\/science.1195227","article-title":"\u03b1-Synuclein promotes SNARE-complex assembly in vivo and in vitro","volume":"329","author":"Burr\u00e9","year":"2010","journal-title":"Science"},{"issue":"20","key":"10.1016\/bs.irn.2026.01.001_bib17","doi-asserted-by":"crossref","first-page":"8797","DOI":"10.1523\/JNEUROSCI.22-20-08797.2002","article-title":"Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking \u03b1-synuclein","volume":"22","author":"Cabin","year":"2002","journal-title":"The Journal of Neuroscience"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.baga.2013.09.001","article-title":"Glutamate in Parkinson\u2019s disease: Role of antiglutamatergic drugs","volume":"3","author":"Carrillo-Mora","year":"2013","journal-title":"Basal Ganglia"},{"key":"10.1016\/bs.irn.2026.01.001_bib19","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neuint.2018.11.007","article-title":"Enhanced AMPA receptor-mediated excitatory transmission in the rodent rostromedial tegmental nucleus following lesion of the nigrostriatal pathway","volume":"122","author":"Chang","year":"2019","journal-title":"Neurochemistry International"},{"key":"10.1016\/bs.irn.2026.01.001_bib20","doi-asserted-by":"crossref","unstructured":"Charvin,\u00a0D.,\u00a0Paolo,\u00a0D.T.,\u00a0Bezard,\u00a0E.,\u00a0Gregoire,\u00a0L.,\u00a0Takano,\u00a0A.,\u00a0Duvey,\u00a0G.,\u00a0\u2026\u00a0Conquet,\u00a0F. (2018).\u00a0A novel mGlu4 PAM alleviates motor symptoms in primate models of PD and of LID.","DOI":"10.1016\/j.jns.2017.08.316"},{"key":"10.1016\/bs.irn.2026.01.001_bib21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.neuroscience.2015.05.035","article-title":"\u03b1-Synuclein-induced internalization of NMDA receptors in hippocampal neurons is associated with reduced inward current and Ca2+ influx upon NMDA stimulation","volume":"300","author":"Chen","year":"2015","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/bs.irn.2026.01.001_bib22","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nn.4549","article-title":"Identification of spinal circuits involved in touch-evoked dynamic mechanical pain","volume":"20","author":"Cheng","year":"2017","journal-title":"Nature Neuroscience"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib23","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neulet.2010.09.061","article-title":"Mitochondrial alpha-synuclein accumulation impairs complex I function in dopaminergic neurons and results in increased mitophagy in vivo","volume":"486","author":"Chinta","year":"2010","journal-title":"Neuroscience Letters"},{"issue":"10","key":"10.1016\/bs.irn.2026.01.001_bib24","doi-asserted-by":"crossref","first-page":"4087","DOI":"10.1073\/pnas.1218424110","article-title":"Large \u03b1-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking","volume":"110","author":"Choi","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib25","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0006-8993(00)02752-9","article-title":"Quisqualate induces an inward current via mGluR activation in neocortical pyramidal neurons","volume":"879","author":"Chu","year":"2000","journal-title":"Brain Research"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib26","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.neuroscience.2009.08.057","article-title":"Dopamine neuron glutamate cotransmission: Frequency-dependent modulation in the mesoventromedial projection","volume":"164","author":"Chuhma","year":"2009","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/bs.irn.2026.01.001_bib27","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1523\/JNEUROSCI.5427-08.2009","article-title":"Dynamic changes in presynaptic and axonal transport proteins combined with striatal neuroinflammation precede dopaminergic neuronal loss in a rat model of AAV \u03b1-synucleinopathy","volume":"29","author":"Chung","year":"2009","journal-title":"The Journal of Neuroscience"},{"issue":"4","key":"10.1016\/bs.irn.2026.01.001_bib28","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/cne.21852","article-title":"Downregulation of glial glutamate transporters after dopamine denervation in the striatum of 6-hydroxydopamine-lesioned rats","volume":"511","author":"Chung","year":"2008","journal-title":"Journal of Comparative Neurology"},{"issue":"10","key":"10.1016\/bs.irn.2026.01.001_bib29","doi-asserted-by":"crossref","first-page":"3306","DOI":"10.1523\/JNEUROSCI.5367-11.2012","article-title":"Endoplasmic reticulum stress is important for the manifestations of \u03b1-synucleinopathy in vivo","volume":"32","author":"Colla","year":"2012","journal-title":"The Journal of Neuroscience"},{"issue":"10","key":"10.1016\/bs.irn.2026.01.001_bib30","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1523\/JNEUROSCI.5368-11.2012","article-title":"Accumulation of toxic \u03b1-synuclein oligomer within endoplasmic reticulum occurs in \u03b1-synucleinopathy in vivo","volume":"32","author":"Colla","year":"2012","journal-title":"The Journal of Neuroscience"},{"issue":"11","key":"10.1016\/bs.irn.2026.01.001_bib31","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/3311","article-title":"Accelerated in vitro fibril formation by a mutant \u03b1-synuclein linked to early-onset Parkinson disease","volume":"4","author":"Conway","year":"1998","journal-title":"Nature Medicine"},{"issue":"12","key":"10.1016\/bs.irn.2026.01.001_bib32","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1046\/j.1460-9568.1998.00371.x","article-title":"Cloning and characterization of alternative mRNA forms for the rat metabotropic glutamate receptors mGluR7 and mGluR8","volume":"10","author":"Corti","year":"1998","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/bs.irn.2026.01.001_bib33","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.neurobiolaging.2017.09.006","article-title":"Altered mGluR5 binding potential and glutamine concentration in the 6-OHDA rat model of acute Parkinson\u2019s disease and levodopa-induced dyskinesia","volume":"61","author":"Crabb\u00e9","year":"2018","journal-title":"Neurobiology of Aging"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"Danbolt","year":"2001","journal-title":"Progress in Neurobiology"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib35","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0306-4522(92)90316-T","article-title":"An [Na+ + K+]coupledl-glutamate transporter purified from rat brain is located in glial cell processes","volume":"51","author":"Danbolt","year":"1992","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/bs.irn.2026.01.001_bib36","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.1007\/s12035-024-04644-0","article-title":"EAAT2 activation regulates glutamate excitotoxicity and reduces impulsivity in a rodent model of Parkinson\u2019s disease","volume":"62","author":"Das","year":"2025","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/bs.irn.2026.01.001_bib37","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson\u2019s disease: Mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"issue":"16","key":"10.1016\/bs.irn.2026.01.001_bib38","doi-asserted-by":"crossref","first-page":"9443","DOI":"10.1074\/jbc.273.16.9443","article-title":"Stabilization of \u03b1-synuclein secondary structure upon binding to synthetic membranes\u204e","volume":"273","author":"Davidson","year":"1998","journal-title":"Journal of Biological Chemistry"},{"issue":"7","key":"10.1016\/bs.irn.2026.01.001_bib39","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1089\/ars.2015.6343","article-title":"Alpha-synuclein oligomers interact with metal ions to induce oxidative stress and neuronal death in Parkinson\u2019s disease","volume":"24","author":"Deas","year":"2015","journal-title":"Antioxidants & Redox Signaling"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib40","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.nbd.2011.12.013","article-title":"Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of \u03b1-synuclein in midbrain dopamine neurons","volume":"45","author":"Decressac","year":"2012","journal-title":"Neurobiology of Disease"},{"issue":"19","key":"10.1016\/bs.irn.2026.01.001_bib41","doi-asserted-by":"crossref","first-page":"E1817","DOI":"10.1073\/pnas.1305623110","article-title":"TFEB-mediated autophagy rescues midbrain dopamine neurons from \u03b1-synuclein toxicity","volume":"110","author":"Decressac","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"34","key":"10.1016\/bs.irn.2026.01.001_bib42","doi-asserted-by":"crossref","first-page":"11750","DOI":"10.1523\/JNEUROSCI.0234-12.2012","article-title":"Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP Via NMDA-receptor activation","volume":"32","author":"Di\u00f3genes","year":"2012","journal-title":"The Journal of Neuroscience"},{"issue":"45","key":"10.1016\/bs.irn.2026.01.001_bib43","doi-asserted-by":"crossref","first-page":"14983","DOI":"10.1523\/JNEUROSCI.2124-15.2015","article-title":"Loss of VGLUT3 produces circadian-dependent hyperdopaminergia and ameliorates motor dysfunction and l-Dopa-mediated dyskinesias in a model of Parkinson\u2019s disease","volume":"35","author":"Divito","year":"2015","journal-title":"The Journal of Neuroscience"},{"issue":"7","key":"10.1016\/bs.irn.2026.01.001_bib44","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1046\/j.1460-9568.1999.00639.x","article-title":"Expression of glutamate transporters in rat optic nerve oligodendrocytes","volume":"11","author":"Domercq","year":"1999","journal-title":"European Journal of Neuroscience"},{"issue":"11","key":"10.1016\/bs.irn.2026.01.001_bib45","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1002\/glia.23472","article-title":"Microglial glutamate release evoked by \u03b1-synuclein aggregates is prevented by dopamine","volume":"66","author":"dos-Santos-Pereira","year":"2018","journal-title":"Glia"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib46","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1750-3639.2008.00186.x","article-title":"Detergent-Insoluble EAAC1\/EAAT3 aberrantly accumulates in hippocampal neurons of Alzheimer\u2019s disease patients","volume":"19","author":"Duerson","year":"2009","journal-title":"Brain Pathology"},{"issue":"5","key":"10.1016\/bs.irn.2026.01.001_bib47","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1093\/brain\/awz065","article-title":"Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration","volume":"142","author":"Durante","year":"2019","journal-title":"Brain"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2010.09.005","article-title":"Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis","volume":"93","author":"Dutta","year":"2011","journal-title":"Progress in Neurobiology"},{"key":"10.1016\/bs.irn.2026.01.001_bib49","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.neuint.2015.07.005","article-title":"Alterations in the motor cortical and striatal glutamatergic system and d-serine levels in the bilateral 6-hydroxydopamine rat model for Parkinson\u2019s disease","volume":"88","author":"El Arfani","year":"2015","journal-title":"Neurochemistry International"},{"issue":"4","key":"10.1016\/bs.irn.2026.01.001_bib50","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nrn2969","article-title":"From glutamate co-release to vesicular synergy: Vesicular glutamate transporters","volume":"12","author":"El Mestikawy","year":"2011","journal-title":"Nature Reviews Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib51","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.brainres.2004.07.074","article-title":"Characterization of modulatory effects of postsynaptic metabotropic glutamate receptors on calcium currents in rat nucleus tractus solitarius","volume":"1024","author":"Endoh","year":"2004","journal-title":"Brain Research"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib52","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4161\/auto.5604","article-title":"Ubiquitination of \u03b1-synuclein and autophagy in Parkinson\u2019s disease","volume":"4","author":"Engelender","year":"2008","journal-title":"Autophagy"},{"issue":"6532","key":"10.1016\/bs.irn.2026.01.001_bib53","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/375599a0","article-title":"An excitatory amino-acid transporter with properties of a ligand-gated chloride channel","volume":"375","author":"Fairman","year":"1995","journal-title":"Nature"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib54","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1471-2202-14-152","article-title":"High-frequency stimulation of the subthalamic nucleus modifies the expression of vesicular glutamate transporters in basal ganglia in a rat model of Parkinson\u2019s disease","volume":"14","author":"Favier","year":"2013","journal-title":"BMC Neuroscience"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib55","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00441-006-0266-5","article-title":"Metabotropic glutamate receptors","volume":"326","author":"Ferraguti","year":"2006","journal-title":"Cell and Tissue Research"},{"key":"10.1016\/bs.irn.2026.01.001_bib56","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.nbd.2015.12.010","article-title":"Role of the atypical vesicular glutamate transporter VGLUT3 in l-DOPA-induced dyskinesia","volume":"87","author":"Gangarossa","year":"2016","journal-title":"Neurobiology of Disease"},{"key":"10.1016\/bs.irn.2026.01.001_bib57","series-title":"Cortex: Statistics and geometry of neuronal connectivity","author":"Garey","year":"1998"},{"key":"10.1016\/bs.irn.2026.01.001_bib58","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.brainres.2013.08.059","article-title":"A partial lesion of the substantia nigra pars compacta and retrorubral field decreases the harmaline-induced glutamate release in the rat cerebellum","volume":"1537","author":"Go\u0142embiowska","year":"2013","journal-title":"Brain Research"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib59","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1523\/JNEUROSCI.17-01-00204.1997","article-title":"Functional properties of AMPA and NMDA receptors expressed in identified types of basal ganglia neurons","volume":"17","author":"G\u00f6tz","year":"1997","journal-title":"The Journal of Neuroscience"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib60","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/nn2052","article-title":"The vesicular glutamate transporter VGLUT3 synergizes striatal acetylcholine tone","volume":"11","author":"Gras","year":"2008","journal-title":"Nature Neuroscience"},{"issue":"11","key":"10.1016\/bs.irn.2026.01.001_bib61","first-page":"S7","article-title":"Anatomy and physiology of glutamate in the CNS","volume":"44","author":"Greenamyre","year":"1994","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib62","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1756-6606-3-12","article-title":"Astrocytic expression of Parkinson\u2019s disease-related A53T \u03b1-synuclein causes neurodegeneration in mice","volume":"3","author":"Gu","year":"2010","journal-title":"Molecular Brain"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib63","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.heares.2010.11.001","article-title":"VGLUT1 and VGLUT2 mRNA expression in the primate auditory pathway","volume":"274","author":"Hackett","year":"2011","journal-title":"Hearing Research"},{"issue":"10","key":"10.1016\/bs.irn.2026.01.001_bib64","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nrn2911","article-title":"Synaptic versus extrasynaptic NMDA receptor signalling: Implications for neurodegenerative disorders","volume":"11","author":"Hardingham","year":"2010","journal-title":"Nature Reviews Neuroscience"},{"issue":"44","key":"10.1016\/bs.irn.2026.01.001_bib65","doi-asserted-by":"crossref","first-page":"27715","DOI":"10.1074\/jbc.271.44.27715","article-title":"Brain glutamate transporter proteins form homomultimers\u204e","volume":"271","author":"Haugeto","year":"1996","journal-title":"Journal of Biological Chemistry"},{"issue":"8","key":"10.1016\/bs.irn.2026.01.001_bib66","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.neuint.2005.03.001","article-title":"Transport of l-[14C]cystine and l-[14C]cysteine by subtypes of high affinity glutamate transporters over-expressed in HEK cells","volume":"46","author":"Hayes","year":"2005","journal-title":"Neurochemistry International"},{"issue":"4","key":"10.1016\/bs.irn.2026.01.001_bib67","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.neuroscience.2003.10.039","article-title":"Localization of VGLUT3, the vesicular glutamate transporter type 3, in the rat brain","volume":"123","author":"Herzog","year":"2004","journal-title":"Neuroscience"},{"issue":"5007","key":"10.1016\/bs.irn.2026.01.001_bib68","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1126\/science.1709304","article-title":"Ca2+ permeability of KA-AMPA\u2014Gated glutamate receptor channels depends on subunit composition","volume":"252","author":"Hollmann","year":"1991","journal-title":"Science"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib69","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuroscience.2005.08.003","article-title":"l-dopa-induced reversal in striatal glutamate following partial depletion of nigrostriatal dopamine with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine","volume":"136","author":"Holmer","year":"2005","journal-title":"Neuroscience"},{"issue":"17","key":"10.1016\/bs.irn.2026.01.001_bib70","doi-asserted-by":"crossref","first-page":"6000","DOI":"10.1523\/JNEUROSCI.5347-11.2012","article-title":"The density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNS","volume":"32","author":"Holmseth","year":"2012","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib71","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00401-018-1907-y","article-title":"Picomolar concentrations of oligomeric alpha-synuclein sensitizes TLR4 to play an initiating role in Parkinson\u2019s disease pathogenesis","volume":"137","author":"Hughes","year":"2019","journal-title":"Acta Neuropathologica"},{"issue":"5","key":"10.1016\/bs.irn.2026.01.001_bib72","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1471-4159.2011.07254.x","article-title":"AMPA-receptor-mediated excitatory synaptic transmission is enhanced by iron-induced \u03b1-synuclein oligomers","volume":"117","author":"H\u00fcls","year":"2011","journal-title":"Journal of Neurochemistry"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib73","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1046\/j.1471-4159.2002.00929.x","article-title":"Native group-III metabotropic glutamate receptors are coupled to the mitogen-activated protein kinase\/phosphatidylinositol-3-kinase pathways","volume":"82","author":"Iacovelli","year":"2002","journal-title":"Journal of Neurochemistry"},{"issue":"4","key":"10.1016\/bs.irn.2026.01.001_bib74","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1124\/molpharm.120.000089","article-title":"Targeting vesicular glutamate transporter machinery: Implications on metabotropic glutamate receptor 5 signaling and behavior","volume":"98","author":"Ibrahim","year":"2020","journal-title":"Molecular Pharmacology"},{"issue":"20","key":"10.1016\/bs.irn.2026.01.001_bib75","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1093\/hmg\/ddg283","article-title":"Alpha-synuclein degradation by serine protease neurosin: Implication for pathogenesis of synucleinopathies","volume":"12","author":"Iwata","year":"2003","journal-title":"Human Molecular Genetics"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib76","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/cns.12587","article-title":"The role of group II metabotropic glutamate receptors in the striatum in electroacupuncture treatment of Parkinsonian rats","volume":"23","author":"Jia","year":"2017","journal-title":"CNS Neuroscience & Therapeutics"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib77","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1750-1326-5-56","article-title":"ER stress response plays an important role in aggregation of \u03b1-synuclein","volume":"5","author":"Jiang","year":"2010","journal-title":"Molecular Neurodegeneration"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib78","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.neuroscience.2007.07.017","article-title":"Activation of presynaptic kainate receptors suppresses GABAergic synaptic transmission in the rat globus pallidus","volume":"149","author":"Jin","year":"2007","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib79","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0304-3940(02)00016-2","article-title":"Human \u03b1-Synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine","volume":"320","author":"Junn","year":"2002","journal-title":"Neuroscience Letters"},{"issue":"9996","key":"10.1016\/bs.irn.2026.01.001_bib80","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"The Lancet"},{"issue":"6414","key":"10.1016\/bs.irn.2026.01.001_bib81","doi-asserted-by":"crossref","DOI":"10.1126\/science.aat8407","article-title":"Poly(ADP-ribose) drives pathologic \u03b1-synuclein neurodegeneration in Parkinson\u2019s disease","volume":"362","author":"Kam","year":"2018","journal-title":"Science"},{"issue":"6403","key":"10.1016\/bs.irn.2026.01.001_bib82","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/360467a0","article-title":"Primary structure and functional characterization of a high-affinity glutamate transporter","volume":"360","author":"Kanai","year":"1992","journal-title":"Nature"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib83","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/jon.12563","article-title":"18F-FPEB PET\/CT shows mGluR5 upregulation in Parkinson\u2019s disease","volume":"29","author":"Kang","year":"2019","journal-title":"Journal of Neuroimaging"},{"issue":"4","key":"10.1016\/bs.irn.2026.01.001_bib84","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.neurobiolaging.2006.02.010","article-title":"Altered expression of vesicular glutamate transporters VGLUT1 and VGLUT2 in Parkinson disease","volume":"28","author":"Kashani","year":"2007","journal-title":"Neurobiology of Aging"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib85","doi-asserted-by":"crossref","first-page":"99","DOI":"10.4149\/gpb_2016031","article-title":"Cerebellar neurochemical and histopathological changes in rat model of Parkinson\u2019s disease induced by intrastriatal injection of rotenone","volume":"36","author":"Khadrawy","year":"2017","journal-title":"General Physiology and Biophysics"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib86","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1038\/ncomms2534","article-title":"Neuron-released oligomeric \u03b1-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia","volume":"4","author":"Kim","year":"2013","journal-title":"Nature Communications"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib87","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/(SICI)1096-9861(19980413)393:3<332::AID-CNE6>3.0.CO;2-2","article-title":"Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: A light and electron microscopic study","volume":"393","author":"Kinoshita","year":"1998","journal-title":"Journal of Comparative Neurology"},{"issue":"24","key":"10.1016\/bs.irn.2026.01.001_bib88","doi-asserted-by":"crossref","first-page":"25497","DOI":"10.1074\/jbc.M400255200","article-title":"Hsp70 reduces \u03b1-synuclein aggregation and toxicity\u204e","volume":"279","author":"Klucken","year":"2004","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib89","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s40478-022-01403-x","article-title":"Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies","volume":"10","author":"Koss","year":"2022","journal-title":"Acta Neuropathologica Communications"},{"issue":"43","key":"10.1016\/bs.irn.2026.01.001_bib90","doi-asserted-by":"crossref","first-page":"8262","DOI":"10.1523\/JNEUROSCI.0823-20.2020","article-title":"VGluT2 expression in dopamine neurons contributes to postlesional striatal reinnervation","volume":"40","author":"Kouwenhoven","year":"2020","journal-title":"The Journal of Neuroscience"},{"issue":"12","key":"10.1016\/bs.irn.2026.01.001_bib91","doi-asserted-by":"crossref","first-page":"9262","DOI":"10.1074\/jbc.M109.081125","article-title":"Direct transfer of \u03b1-synuclein from neuron to astroglia causes inflammatory responses in synucleinopathies\u204e","volume":"285","author":"Lee","year":"2010","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"10.1016\/bs.irn.2026.01.001_bib92","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.neuron.2014.10.021","article-title":"An unconventional glutamatergic circuit in the retina formed by vGluT3 amacrine cells","volume":"84","author":"Lee","year":"2014","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib93","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1523\/JNEUROSCI.15-03-01835.1995","article-title":"Differential expression of two glial glutamate transporters in the rat brain: Quantitative and immunocytochemical observations","volume":"15","author":"Lehre","year":"1995","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/bs.irn.2026.01.001_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102462","article-title":"Dual-targeted autoimmune sword in fatal epilepsy: patient\u2019s glutamate receptor AMPA GluR3B peptide autoimmune antibodies bind, induce reactive oxygen species (ROS) in, and kill both human neural cells and T cells","volume":"112","author":"Levite","year":"2020","journal-title":"Journal of Autoimmunity"},{"key":"10.1016\/bs.irn.2026.01.001_bib95","article-title":"Effects of combined bushen zhichan recipe and levodopa in a rodent model of Parkinson disease: Potential mechanisms","volume":"26","author":"Li","year":"2020","journal-title":"Medical Science Monitor"},{"issue":"5","key":"10.1016\/bs.irn.2026.01.001_bib96","doi-asserted-by":"crossref","first-page":"bio038257","DOI":"10.1242\/bio.038257","article-title":"Blockage of glutamine-dependent anaplerosis affects mTORC1\/2 activity and ultimately leads to cellular senescence-like response","volume":"8","author":"Liao","year":"2019","journal-title":"Biology Open"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib97","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/ejn.12383","article-title":"Stimulating ERK\/PI3K\/NF\u03baB signaling pathways upon activation of mGluR2\/3 restores OGD-induced impairment in glutamate clearance in astrocytes","volume":"39","author":"Lin","year":"2014","journal-title":"European Journal of Neuroscience"},{"issue":"13","key":"10.1016\/bs.irn.2026.01.001_bib98","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.4155\/fmc.12.122","article-title":"Glutamate transporter EAAT2: A new target for the treatment of neurodegenerative diseases","volume":"4","author":"Lin","year":"2012","journal-title":"Future Medicinal Chemistry"},{"issue":"14","key":"10.1016\/bs.irn.2026.01.001_bib99","doi-asserted-by":"crossref","DOI":"10.18632\/aging.102095","article-title":"Ginsenoside Rb1 regulates prefrontal cortical GABAergic transmission in MPTP-treated mice","volume":"11","author":"Liu","year":"2019","journal-title":"Aging"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib100","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1038\/s41467-018-04422-2","article-title":"\u03b1-Synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson\u2019s disease","volume":"9","author":"Ludtmann","year":"2018","journal-title":"Nature Communications"},{"issue":"31","key":"10.1016\/bs.irn.2026.01.001_bib101","doi-asserted-by":"crossref","first-page":"21490","DOI":"10.1074\/jbc.M113.545749","article-title":"Soluble, prefibrillar \u03b1-synuclein oligomers promote complex i-dependent, Ca2+-induced mitochondrial dysfunction\u204e","volume":"289","author":"Luth","year":"2014","journal-title":"Journal of Biological Chemistry"},{"issue":"10","key":"10.1016\/bs.irn.2026.01.001_bib102","doi-asserted-by":"crossref","first-page":"7669","DOI":"10.1007\/s12035-018-0945-8","article-title":"The metabolic disturbances of motoneurons exposed to glutamate","volume":"55","author":"Madji Hounoum","year":"2018","journal-title":"Molecular Neurobiology"},{"issue":"12","key":"10.1016\/bs.irn.2026.01.001_bib103","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1038\/cdd.2015.79","article-title":"Fibril growth and seeding capacity play key roles in \u03b1-synuclein-mediated apoptotic cell death","volume":"22","author":"Mahul-Mellier","year":"2015","journal-title":"Cell Death & Differentiation"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib104","doi-asserted-by":"crossref","first-page":"5182","DOI":"10.1038\/ncomms6182","article-title":"Parkin regulates kainate receptors by interacting with the GluK2 subunit","volume":"5","author":"Maraschi","year":"2014","journal-title":"Nature Communications"},{"issue":"10","key":"10.1016\/bs.irn.2026.01.001_bib105","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.3390\/biom10101370","article-title":"Take advantage of glutamine anaplerosis, the kernel of the metabolic rewiring in malignant gliomas","volume":"10","author":"Martins","year":"2020","journal-title":"Biomolecules"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib106","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neuint.2010.04.019","article-title":"Biphasic and bilateral changes in striatal VGLUT1 and 2 protein expression in hemi-Parkinson rats","volume":"57","author":"Massie","year":"2010","journal-title":"Neurochemistry International"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib107","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40478-020-0894-0","article-title":"Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by \u03b1-synuclein","volume":"8","author":"McKinnon","year":"2020","journal-title":"Acta Neuropathologica Communications"},{"issue":"11","key":"10.1016\/bs.irn.2026.01.001_bib108","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1097\/00001756-200208070-00018","article-title":"Proteasome inhibition causes nigral degeneration with inclusion bodies in rats","volume":"13","author":"McNaught","year":"2002","journal-title":"NeuroReport"},{"key":"10.1016\/bs.irn.2026.01.001_bib109","first-page":"890","article-title":"\u03b1-Synuclein misfolding and aggregation: Implications in Parkinson\u2019s disease pathogenesis","volume":"vol. 1867","author":"Mehra","year":"2019"},{"key":"10.1016\/bs.irn.2026.01.001_bib110","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.3389\/fncel.2015.00245","article-title":"NMDA receptor GluN2A\/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: From experimental models to patients","volume":"9","author":"Mellone","year":"2015","journal-title":"Frontiers in Cellular Neuroscience"},{"key":"10.1016\/bs.irn.2026.01.001_bib111","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.nbd.2018.09.021","article-title":"NMDA receptor GluN2D subunit participates to levodopa-induced dyskinesia pathophysiology","volume":"121","author":"Mellone","year":"2019","journal-title":"Neurobiology of Disease"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib112","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12974-016-0698-0","article-title":"Astroglia acquires a toxic neuroinflammatory role in response to the cerebrospinal fluid from amyotrophic lateral sclerosis patients","volume":"13","author":"Mishra","year":"2016","journal-title":"Journal of Neuroinflammation"},{"issue":"10","key":"10.1016\/bs.irn.2026.01.001_bib113","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0165-6147(00)89070-7","article-title":"NMDA receptor-dependent excitotoxicity: The role of intracellular Ca2+ release","volume":"16","author":"Mody","year":"1995","journal-title":"Trends in Pharmacological Sciences"},{"issue":"14","key":"10.1016\/bs.irn.2026.01.001_bib114","doi-asserted-by":"crossref","first-page":"5023","DOI":"10.1523\/JNEUROSCI.2907-13.2014","article-title":"Differential effects of synaptic and extrasynaptic NMDA receptors on A\u03b2-induced nitric oxide production in cerebrocortical neurons","volume":"34","author":"Molokanova","year":"2014","journal-title":"The Journal of Neuroscience"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib115","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrn.2016.165","article-title":"Ventral tegmental area: Cellular heterogeneity, connectivity and behaviour","volume":"18","author":"Morales","year":"2017","journal-title":"Nature Reviews Neuroscience"},{"key":"10.1016\/bs.irn.2026.01.001_bib116","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neuroscience.2014.05.032","article-title":"Glutamate neurons within the midbrain dopamine regions","volume":"282","author":"Morales","year":"2014","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib117","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/jnc.13204","article-title":"Time and space profiling of NMDA receptor co-agonist functions","volume":"135","author":"Mothet","year":"2015","journal-title":"Journal of Neurochemistry"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib118","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1471-4159.2007.05146.x","article-title":"Preferential vulnerability of mesencephalic dopamine neurons to glutamate transporter dysfunction","volume":"105","author":"Nafia","year":"2008","journal-title":"Journal of Neurochemistry"},{"issue":"16","key":"10.1016\/bs.irn.2026.01.001_bib119","doi-asserted-by":"crossref","first-page":"11868","DOI":"10.1016\/S0021-9258(19)50280-0","article-title":"Molecular characterization of a novel retinal metabotropic glutamate receptor mGluR6 with a high agonist selectivity for L-2-amino-4-phosphonobutyrate","volume":"268","author":"Nakajima","year":"1993","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/bs.irn.2026.01.001_bib120","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neuint.2015.03.008","article-title":"Alpha-synuclein modulates NR2B-containing NMDA receptors and decreases their levels after rotenone exposure","volume":"85\u201386","author":"Navarria","year":"2015","journal-title":"Neurochemistry International"},{"issue":"7","key":"10.1016\/bs.irn.2026.01.001_bib121","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.neuropharm.2010.10.022","article-title":"Metabotropic glutamate receptors: From the workbench to the bedside","volume":"60","author":"Nicoletti","year":"2011","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/bs.irn.2026.01.001_bib122","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.neurobiolaging.2005.04.010","article-title":"Increased sensitivity to MPTP in human \u03b1-synuclein A30P transgenic mice","volume":"27","author":"Nieto","year":"2006","journal-title":"Neurobiology of Aging"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib123","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0896-6273(94)90459-6","article-title":"Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex","volume":"13","author":"Ohishi","year":"1994","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib124","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/ana.21539","article-title":"Glutamate receptors on myelinated spinal cord axons: II. AMPA and GluR5 receptors","volume":"65","author":"Ouardouz","year":"2009","journal-title":"Annals of Neurology"},{"issue":"4","key":"10.1016\/bs.irn.2026.01.001_bib125","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.neuroscience.2010.03.022","article-title":"Changes of AMPA receptors in MPTP monkeys with levodopa-induced dyskinesias","volume":"167","author":"Ouattara","year":"2010","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib126","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.coph.2006.08.011","article-title":"NMDA receptor subunits: Function and pharmacology","volume":"7","author":"Paoletti","year":"2007","journal-title":"Current Opinion in Pharmacology"},{"key":"10.1016\/bs.irn.2026.01.001_bib127","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.3389\/fphar.2019.00002","article-title":"The protective effects of PSM-04 against beta amyloid-induced neurotoxicity in primary cortical neurons and an animal model of Alzheimer\u2019s disease","volume":"10","author":"Park","year":"2019","journal-title":"Frontiers in Pharmacology"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib128","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1177\/1073858403260159","article-title":"Neuroenergetics: Calling upon astrocytes to satisfy hungry neurons","volume":"10","author":"Pellerin","year":"2004","journal-title":"The Neuroscientist"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0028-3908(94)00129-G","article-title":"The metabotropic glutamate receptors: Structure and functions","volume":"34","author":"Pin","year":"1995","journal-title":"Neuropharmacology"},{"issue":"6403","key":"10.1016\/bs.irn.2026.01.001_bib130","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/360464a0","article-title":"Cloning and expression of a rat brain L-glutamate transporter","volume":"360","author":"Pines","year":"1992","journal-title":"Nature"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib131","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s00441-006-0265-6","article-title":"Kainate receptors","volume":"326","author":"Pinheiro","year":"2006","journal-title":"Cell and Tissue Research"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib132","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.tvjl.2005.11.007","article-title":"The role of glutamate in central nervous system health and disease \u2013 A review","volume":"173","author":"Platt","year":"2007","journal-title":"The Veterinary Journal"},{"issue":"6","key":"10.1016\/bs.irn.2026.01.001_bib133","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1016\/j.bbagen.2014.02.013","article-title":"Number and brightness analysis of alpha-synuclein oligomerization and the associated mitochondrial morphology alterations in live cells","volume":"1840","author":"Plotegher","year":"2014","journal-title":"Biochimica et Biophysica Acta (BBA)\u00a0- General Subjects"},{"key":"10.1016\/bs.irn.2026.01.001_bib134","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.ceca.2019.04.001","article-title":"Extracellular mild acidosis decreases the Ca2+ permeability of the human NMDA receptors","volume":"80","author":"Plutino","year":"2019","journal-title":"Cell Calcium"},{"issue":"7","key":"10.1016\/bs.irn.2026.01.001_bib135","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1111\/j.1460-9568.2008.06136.x","article-title":"Differential synaptic plasticity of the corticostriatal and thalamostriatal systems in an MPTP-treated monkey model of parkinsonism","volume":"27","author":"Raju","year":"2008","journal-title":"European Journal of Neuroscience"},{"issue":"5","key":"10.1016\/bs.irn.2026.01.001_bib136","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1093\/brain\/awu057","article-title":"Accumulation of oligomer-prone \u03b1-synuclein exacerbates synaptic and neuronal degeneration in vivo","volume":"137","author":"Rockenstein","year":"2014","journal-title":"Brain"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib137","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/cne.903550310","article-title":"Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain","volume":"355","author":"Romano","year":"1995","journal-title":"Journal of Comparative Neurology"},{"issue":"9","key":"10.1016\/bs.irn.2026.01.001_bib138","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1002\/jnr.24024","article-title":"Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated \u03b1-synuclein","volume":"95","author":"Sarafian","year":"2017","journal-title":"Journal of Neuroscience Research"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib139","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/nn.2248","article-title":"A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles","volume":"12","author":"Schenck","year":"2009","journal-title":"Nature Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib140","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0022-3565(24)29296-X","article-title":"Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system","volume":"299","author":"Schoepp","year":"2001","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/bs.irn.2026.01.001_bib141","series-title":"Proceedings of the 1993 laurentian hormone conference","first-page":"19","article-title":"The NMDA receptor channel: Molecular design of a coincidence detector","volume":"Vol. 50","author":"Seeburg","year":"1995"},{"issue":"15","key":"10.1016\/bs.irn.2026.01.001_bib142","doi-asserted-by":"crossref","first-page":"6372","DOI":"10.1523\/JNEUROSCI.22-15-06372.2002","article-title":"A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy","volume":"22","author":"Sepkuty","year":"2002","journal-title":"The Journal of Neuroscience"},{"issue":"16","key":"10.1016\/bs.irn.2026.01.001_bib143","doi-asserted-by":"crossref","first-page":"9110","DOI":"10.1073\/pnas.171300598","article-title":"\u03b1-Synuclein occurs in lipid-rich high molecular weight complexes, binds fatty acids, and shows homology to the fatty acid-binding proteins","volume":"98","author":"Sharon","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib144","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0006-8993(97)00921-9","article-title":"Immunohistochemical localization of the neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spinal cord revealed by a novel monoclonal antibody","volume":"773","author":"Shashidharan","year":"1997","journal-title":"Brain Research"},{"issue":"49","key":"10.1016\/bs.irn.2026.01.001_bib145","doi-asserted-by":"crossref","first-page":"E11532","DOI":"10.1073\/pnas.1800886115","article-title":"Genetic deletion of vesicular glutamate transporter in dopamine neurons increases vulnerability to MPTP-induced neurotoxicity in mice","volume":"115","author":"Shen","year":"2018","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"5","key":"10.1016\/bs.irn.2026.01.001_bib146","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1007\/s00401-014-1314-y","article-title":"Plasma exosomal \u03b1-synuclein is likely CNS-derived and increased in Parkinson\u2019s disease","volume":"128","author":"Shi","year":"2014","journal-title":"Acta Neuropathologica"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib147","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3940(93)90227-C","article-title":"Immunohistochemical localization of a metabotropic glutamate receptor, mGluR5, in the rat brain","volume":"163","author":"Shigemoto","year":"1993","journal-title":"Neuroscience Letters"},{"issue":"1338","key":"10.1016\/bs.irn.2026.01.001_bib148","first-page":"297","article-title":"Presynaptic inhibitory action of a metabotropic glutamate receptor agonist on excitatory transmission in visual cortical neurons","volume":"253","author":"Sladeczek","year":"1997","journal-title":"Proceedings of the Royal Society of London. Series B: Biological Sciences"},{"issue":"8","key":"10.1016\/bs.irn.2026.01.001_bib149","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3390\/cells11081261","article-title":"GBA variants and Parkinson disease: Mechanisms and treatments","volume":"11","author":"Smith","year":"2022","journal-title":"Cells"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib150","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/brain\/awab373","article-title":"Dopamine neurons exhibit emergent glutamatergic identity in Parkinson\u2019s disease","volume":"145","author":"Steinkellner","year":"2022","journal-title":"Brain"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib151","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1172\/JCI95795","article-title":"Role for VGLUT2 in selective vulnerability of midbrain dopamine neurons","volume":"128","author":"Steinkellner","year":"2018","journal-title":"Journal of Clinical Investigation"},{"issue":"22","key":"10.1016\/bs.irn.2026.01.001_bib152","doi-asserted-by":"crossref","first-page":"10955","DOI":"10.1073\/pnas.89.22.10955","article-title":"Structure, expression, and functional analysis of a Na(+)-dependent glutamate\/aspartate transporter from rat brain","volume":"89","author":"Storck","year":"1992","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"18","key":"10.1016\/bs.irn.2026.01.001_bib153","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1093\/hmg\/9.18.2683","article-title":"Expression of mutant \u03b1-synuclein causes increased susceptibility to dopamine toxicity","volume":"9","author":"Tabrizi","year":"2000","journal-title":"Human Molecular Genetics"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib154","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0304-3940(93)90105-T","article-title":"MPTP neurotoxicity to cerebellar Purkinje cells in mice","volume":"150","author":"Takada","year":"1993","journal-title":"Neuroscience Letters"},{"issue":"27","key":"10.1016\/bs.irn.2026.01.001_bib155","doi-asserted-by":"crossref","first-page":"E2518","DOI":"10.1073\/pnas.1306832110","article-title":"A\u03b2 induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss","volume":"110","author":"Talantova","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/bs.irn.2026.01.001_bib156","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuro.2018.08.008","article-title":"AMPA-induced extracellular Zn2+ influx into nigral dopaminergic neurons causes movement disorder in rats","volume":"69","author":"Tamano","year":"2018","journal-title":"NeuroToxicology"},{"issue":"11","key":"10.1016\/bs.irn.2026.01.001_bib157","doi-asserted-by":"crossref","first-page":"7789","DOI":"10.1007\/s12035-019-01642-5","article-title":"Paraquat as an environmental risk factor in Parkinson\u2019s disease accelerates age-related degeneration via rapid influx of extracellular Zn2+ into nigral dopaminergic neurons","volume":"56","author":"Tamano","year":"2019","journal-title":"Molecular Neurobiology"},{"issue":"5319","key":"10.1016\/bs.irn.2026.01.001_bib158","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1126\/science.276.5319.1699","article-title":"Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1","volume":"276","author":"Tanaka","year":"1997","journal-title":"Science"},{"key":"10.1016\/bs.irn.2026.01.001_bib159","first-page":"141","article-title":"Chapter 6 - The multilingual nature of dopamine neurons","volume":"vol. 211","author":"Trudeau","year":"2014"},{"issue":"10","key":"10.1016\/bs.irn.2026.01.001_bib160","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1523\/JNEUROSCI.1871-20.2020","article-title":"\u03b1-Synuclein oligomers induce glutamate release from astrocytes and excessive extrasynaptic NMDAR activity in neurons, thus contributing to synapse loss","volume":"41","author":"Trudler","year":"2021","journal-title":"The Journal of Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib161","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.00042.2016","article-title":"Physiology of astroglia","volume":"98","author":"Verkhratsky","year":"2017","journal-title":"Physiological Reviews"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib162","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/s12264-018-0213-y","article-title":"Electroacupuncture alleviates motor symptoms and up-regulates vesicular glutamatergic transporter 1 expression in the subthalamic nucleus in a unilateral 6-hydroxydopamine-lesioned hemi-Parkinsonian rat model","volume":"34","author":"Wang","year":"2018","journal-title":"Neuroscience Bulletin"},{"key":"10.1016\/bs.irn.2026.01.001_bib163","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.freeradbiomed.2013.08.166","article-title":"NOX2 deficiency ameliorates cerebral injury through reduction of complexin II-mediated glutamate excitotoxicity in experimental stroke","volume":"65","author":"Wang","year":"2013","journal-title":"Free Radical Biology and Medicine"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib164","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.neuroscience.2009.01.021","article-title":"Alterations in corticostriatal synaptic plasticity in mice overexpressing human \u03b1-synuclein","volume":"159","author":"Watson","year":"2009","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib165","article-title":"Wnt1 Promotes EAAT2 expression and mediates the protective effects of astrocytes on dopaminergic cells in Parkinson\u2019s disease","volume":"2019","author":"Wei","year":"2019","journal-title":"Neural Plasticity"},{"issue":"43","key":"10.1016\/bs.irn.2026.01.001_bib166","doi-asserted-by":"crossref","first-page":"13709","DOI":"10.1021\/bi961799n","article-title":"NACP, a protein implicated in Alzheimer\u2019s disease and learning, is natively unfolded","volume":"35","author":"Weinreb","year":"1996","journal-title":"Biochemistry"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib167","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.neuron.2008.04.002","article-title":"Astrocytes in the epileptic brain","volume":"58","author":"Wetherington","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/bs.irn.2026.01.001_bib168","first-page":"53","article-title":"Pathophysiology of parkinsonian motor abnormalities","volume":"60","author":"Wichmann","year":"1993","journal-title":"Advances in Neurology"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib169","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12035-018-1082-0","article-title":"Extracellular alpha-synuclein oligomers induce parkin s-nitrosylation: Relevance to sporadic Parkinson\u2019s disease etiopathology","volume":"56","author":"Wilkaniec","year":"2019","journal-title":"Molecular Neurobiology"},{"issue":"18","key":"10.1016\/bs.irn.2026.01.001_bib170","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.1073\/pnas.0401764101","article-title":"An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size","volume":"101","author":"Wojcik","year":"2004","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"3","key":"10.1016\/bs.irn.2026.01.001_bib171","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nn2047","article-title":"Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis","volume":"11","author":"Yamanaka","year":"2008","journal-title":"Nature Neuroscience"},{"issue":"2","key":"10.1016\/bs.irn.2026.01.001_bib172","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1523\/JNEUROSCI.2289-15.2016","article-title":"Dynamic changes in striatal mGluR1 but not mGluR5 during pathological progression of Parkinson\u2019s disease in human alpha-synuclein A53T\u00a0transgenic rats: A multi-PET imaging study","volume":"36","author":"Yamasaki","year":"2016","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/bs.irn.2026.01.001_bib173","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.neulet.2015.11.023","article-title":"Overexpression of \u03b1-synuclein simultaneously increases glutamate NMDA receptor phosphorylation and reduces glucocerebrosidase activity","volume":"611","author":"Yang","year":"2016","journal-title":"Neuroscience Letters"},{"key":"10.1016\/bs.irn.2026.01.001_bib174","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neurobiolaging.2020.02.015","article-title":"Alpha-synuclein differentially reduces surface expression of N-methyl-d-aspartate receptors in the aging human brain","volume":"90","author":"Yang","year":"2020","journal-title":"Neurobiology of Aging"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib175","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/4235695","article-title":"Mn Inhibits GSH synthesis via downregulation of neuronal EAAC1 and astrocytic xCT to cause oxidative damage in the striatum of mice","volume":"2018","author":"Yang","year":"2018","journal-title":"Oxidative Medicine and Cellular Longevity"},{"issue":"7933","key":"10.1016\/bs.irn.2026.01.001_bib176","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41586-022-05319-3","article-title":"Structures of \u03b1-synuclein filaments from human brains with Lewy pathology","volume":"610","author":"Yang","year":"2022","journal-title":"Nature"},{"issue":"6601","key":"10.1016\/bs.irn.2026.01.001_bib177","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/383634a0","article-title":"Flux coupling in a neuronal glutamate transporter","volume":"383","author":"Zerangue","year":"1996","journal-title":"Nature"},{"issue":"6","key":"10.1016\/bs.irn.2026.01.001_bib178","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1080\/09168451.2019.1578639","article-title":"Effect and mechanism of mGluR6 on the biological function of rat embryonic neural stem cells","volume":"83","author":"Zhang","year":"2019","journal-title":"Bioscience, Biotechnology, and Biochemistry"},{"issue":"9","key":"10.1016\/bs.irn.2026.01.001_bib179","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000014683","article-title":"Effect of mGluR7 on proliferation of human embryonic neural stem cells","volume":"98","author":"Zhang","year":"2019","journal-title":"Medicine"},{"issue":"1","key":"10.1016\/bs.irn.2026.01.001_bib180","article-title":"Recent advance in the relationship between excitatory amino acid transporters and Parkinson\u2019s disease","volume":"2016","author":"Zhang","year":"2016","journal-title":"Neural Plasticity"},{"key":"10.1016\/bs.irn.2026.01.001_bib181","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.neuropharm.2017.12.012","article-title":"Ginsenoside Rb1 confers neuroprotection via promotion of glutamate transporters in a mouse model of Parkinson\u2019s disease","volume":"131","author":"Zhang","year":"2018","journal-title":"Neuropharmacology"},{"issue":"12","key":"10.1016\/bs.irn.2026.01.001_bib182","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0190160","article-title":"Running wheel exercise reduces \u03b1-synuclein aggregation and improves motor and cognitive function in a transgenic mouse model of Parkinson\u2019s disease","volume":"12","author":"Zhou","year":"2017","journal-title":"PLoS ONE"}],"container-title":["International Review of Neurobiology","Brain Energy Metabolism in Alzheimers Disease - Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774226000012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0074774226000012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T20:01:41Z","timestamp":1781208101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0074774226000012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443344435"],"references-count":182,"URL":"https:\/\/doi.org\/10.1016\/bs.irn.2026.01.001","relation":{},"ISSN":["0074-7742"],"issn-type":[{"value":"0074-7742","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}