{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T21:51:46Z","timestamp":1768513906529,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier","isbn-type":[{"value":"9780128170823","type":"print"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/bs.mcb.2019.05.005","type":"book-chapter","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T08:52:14Z","timestamp":1560415934000},"page":"1-23","source":"Crossref","is-referenced-by-count":12,"title":["Generation of primary cells from ADPKD and normal human kidneys"],"prefix":"10.1016","author":[{"given":"Darren P.","family":"Wallace","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail A.","family":"Reif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/bs.mcb.2019.05.005_bb0010","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/j.1523-1755.2004.00843.x","article-title":"Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells","volume":"66","author":"Belibi","year":"2004","journal-title":"Kidney International"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0015","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1172\/JCI119147","article-title":"Loss of the polycystic kidney disease (PKD1) region of chromosome 16p13 in renal cyst cells supports a loss-of-function model for cyst pathogenesis","volume":"99","author":"Brasier","year":"1997","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0020","first-page":"648","article-title":"Cell polarity in human renal cystic disease","volume":"70","author":"Carone","year":"1994","journal-title":"Laboratory Investigation"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0025","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1681\/ASN.2012070650","article-title":"Type of PKD1 mutation influences renal outcome in ADPKD","volume":"24","author":"Cornec-Le Gall","year":"2013","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0030","article-title":"Culturing primary rat inner medullary collecting duct cells","volume":"76","author":"Faust","year":"2013","journal-title":"Journal of Visualized Experiments"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0035","first-page":"158","article-title":"Net fluid secretion by mammalian renal epithelial cells: Stimulation by cAMP in polarized cultures derived from established renal cells and from normal and polycystic kidneys","volume":"102","author":"Grantham","year":"1989","journal-title":"Transactions of the Association of American Physicians"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0040","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nrneph.2011.109","article-title":"Why kidneys fail in autosomal dominant polycystic kidney disease","volume":"7","author":"Grantham","year":"2011","journal-title":"Nature Reviews. Nephrology"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0045","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1681\/ASN.2010030328","article-title":"What is the role of somatic mutation in autosomal dominant polycystic kidney disease?","volume":"21","author":"Harris","year":"2010","journal-title":"Journal of the American Society of Nephrology: JASN"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0050","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/path.1700910204","article-title":"A microdissection study of cystic disease of the kidneys in adults","volume":"91","author":"Heggo","year":"1966","journal-title":"The Journal of Pathology and Bacteriology"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0055","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1172\/JCI114736","article-title":"Enhancement of electrogenic Na+ transport across rat inner medullary collecting duct by glucocorticoid and by mineralocorticoid hormones","volume":"86","author":"Husted","year":"1990","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0060","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1038\/s41598-018-21132-3","article-title":"Aberrant regulation of Notch3 signaling pathway in polycystic kidney disease","volume":"8","author":"Idowu","year":"2018","journal-title":"Scientific Reports"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0065","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.kint.2018.06.025","article-title":"CD8(+) T cells modulate autosomal dominant polycystic kidney disease progression","volume":"94","author":"Kleczko","year":"2018","journal-title":"Kidney International"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0070","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1681\/ASN.2018040442","article-title":"Human-specific abnormal alternative splicing of wild-type PKD1 induces premature termination of Polycystin-1","volume":"29","author":"Lea","year":"2018","journal-title":"Journal of the American Society of Nephrology: JASN"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0075","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1096\/fasebj.3.14.2480260","article-title":"Renal epithelial fluid secretion and cyst growth: The role of cyclic AMP","volume":"3","author":"Mangoo-Karim","year":"1989","journal-title":"The FASEB Journal"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0080","first-page":"F381","article-title":"Anion secretion drives fluid secretion by monolayers of cultured human polycystic cells","volume":"269","author":"Mangoo-Karim","year":"1995","journal-title":"The American Journal of Physiology"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0085","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1681\/ASN.2015010047","article-title":"Phosphodiesterase isoform regulation of cell proliferation and fluid secretion in autosomal dominant polycystic kidney disease","volume":"27","author":"Pinto","year":"2016","journal-title":"Journal of the American Society of Nephrology: JASN"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0090","doi-asserted-by":"crossref","first-page":"F1412","DOI":"10.1152\/ajprenal.00692.2011","article-title":"Calmodulin-sensitive adenylyl cyclases mediate AVP-dependent cAMP production and cl- secretion by human autosomal dominant polycystic kidney cells","volume":"303","author":"Pinto","year":"2012","journal-title":"American Journal of Physiology. Renal Physiology"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0095","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1681\/ASN.2016111235","article-title":"Integrin-linked kinase signaling promotes cyst growth and fibrosis in polycystic kidney disease","volume":"28","author":"Raman","year":"2017","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0100","doi-asserted-by":"crossref","first-page":"F1005","DOI":"10.1152\/ajprenal.00243.2011","article-title":"Tolvaptan inhibits ERK-dependent cell proliferation, cl(\u2212) secretion, and in vitro cyst growth of human ADPKD cells stimulated by vasopressin","volume":"301","author":"Reif","year":"2011","journal-title":"American Journal of Physiology. Renal Physiology"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0105","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/ki.1982.201","article-title":"Water, urea, sodium, chloride, and potassium transport in the in vitro isolated perfused papillary collecting duct","volume":"22","author":"Rocha","year":"1982","journal-title":"Kidney International"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0110","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/ki.2008.686","article-title":"Incompletely penetrant PKD1 alleles suggest a role for gene dosage in cyst initiation in polycystic kidney disease","volume":"75","author":"Rossetti","year":"2009","journal-title":"Kidney International"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0115","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1172\/JCI112774","article-title":"Urea permeability of mammalian inner medullary collecting duct system and papillary surface epithelium","volume":"79","author":"Sands","year":"1987","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0120","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1073\/pnas.0509694103","article-title":"The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease","volume":"103","author":"Shillingford","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0125","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1038\/s41598-018-23341-2","article-title":"Inhibition of hedgehog signaling suppresses proliferation and microcyst formation of human autosomal dominant polycystic kidney disease cells","volume":"8","author":"Silva","year":"2018","journal-title":"Scientific Reports"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0130","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1093\/hmg\/ddp165","article-title":"Systems biology of autosomal dominant polycystic kidney disease (ADPKD): Computational identification of gene expression pathways and integrated regulatory networks","volume":"18","author":"Song","year":"2009","journal-title":"Human Molecular Genetics"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0135","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/ki.2012.446","article-title":"Macrophages promote polycystic kidney disease progression","volume":"83","author":"Swenson-Fields","year":"2013","journal-title":"Kidney International"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0140","first-page":"457","article-title":"Histogenesis of the renal cysts in adult (autosomal dominant) polycystic kidney disease: A histochemical study","volume":"1","author":"Verani","year":"1988","journal-title":"Modern Pathology"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0145","doi-asserted-by":"crossref","first-page":"F1337","DOI":"10.1152\/ajprenal.00165.2002","article-title":"Electrolyte and fluid secretion by cultured human inner medullary collecting duct cells","volume":"283","author":"Wallace","year":"2002","journal-title":"American Journal of Physiology. Renal Physiology"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0150","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1038\/ki.1996.445","article-title":"Chloride and fluid secretion by cultured human polycystic kidney cells","volume":"50","author":"Wallace","year":"1996","journal-title":"Kidney International"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0155","doi-asserted-by":"crossref","first-page":"F1463","DOI":"10.1152\/ajprenal.90266.2008","article-title":"Periostin induces proliferation of human autosomal dominant polycystic kidney cells through alpha V-integrin receptor","volume":"295","author":"Wallace","year":"2008","journal-title":"American Journal of Physiology. Renal Physiology"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0160","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S0272-6386(12)80338-6","article-title":"Aberrant epithelial cell growth in autosomal dominant polycystic kidney disease","volume":"17","author":"Wilson","year":"1991","journal-title":"American Journal of Kidney Diseases"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0165","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/jcp.1041500220","article-title":"Abnormal extracellular matrix and excessive growth of human adult polycystic kidney disease epithelia","volume":"150","author":"Wilson","year":"1992","journal-title":"Journal of Cellular Physiology"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0170","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0092-8674(00)81570-6","article-title":"Somatic inactivation of Pkd2 results in polycystic kidney disease","volume":"93","author":"Wu","year":"1998","journal-title":"Cell"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0175","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1681\/ASN.2005060645","article-title":"Calcium restores a normal proliferation phenotype in human polycystic kidney disease epithelial cells","volume":"17","author":"Yamaguchi","year":"2006","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0180","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1046\/j.1523-1755.2003.00023.x","article-title":"Cyclic AMP activates B-Raf and ERK in cyst epithelial cells from autosomal-dominant polycystic kidneys","volume":"63","author":"Yamaguchi","year":"2003","journal-title":"Kidney International"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0185","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1046\/j.1523-1755.2000.00991.x","article-title":"cAMP stimulates the in vitro proliferation of renal cyst epithelial cells by activating the extracellular signal-regulated kinase pathway","volume":"57","author":"Yamaguchi","year":"2000","journal-title":"Kidney International"},{"key":"10.1016\/bs.mcb.2019.05.005_bb0190","doi-asserted-by":"crossref","first-page":"F944","DOI":"10.1152\/ajprenal.00387.2010","article-title":"Sorafenib inhibits cAMP-dependent ERK activation, cell proliferation, and in vitro cyst growth of human ADPKD cyst epithelial cells","volume":"299","author":"Yamaguchi","year":"2010","journal-title":"American Journal of Physiology. Renal Physiology"}],"container-title":["Methods in Cell Biology","Methods in Kidney Cell Biology - Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X19300743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X19300743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T13:06:36Z","timestamp":1565010396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091679X19300743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9780128170823"],"references-count":37,"URL":"https:\/\/doi.org\/10.1016\/bs.mcb.2019.05.005","relation":{},"ISSN":["0091-679X"],"issn-type":[{"value":"0091-679X","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}