{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T19:06:22Z","timestamp":1772305582679,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier","isbn-type":[{"value":"9780323992190","type":"print"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/bs.mcb.2024.01.005","type":"book-chapter","created":{"date-parts":[[2024,2,24]],"date-time":"2024-02-24T08:05:10Z","timestamp":1708761910000},"page":"59-75","source":"Crossref","is-referenced-by-count":1,"title":["Quantification of mitochondrial reactive oxygen species in macrophages during sepsis"],"prefix":"10.1016","member":"78","reference":[{"key":"10.1016\/bs.mcb.2024.01.005_bb0010","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(02)09459-X","article-title":"Association between mitochondrial dysfunction and severity and outcome of septic shock","volume":"360","author":"Brealey","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0015","doi-asserted-by":"crossref","DOI":"10.1172\/JCI159498","article-title":"Mitochondrial dysfunction in macrophages promotes inflammation and suppresses repair after myocardial infarction","volume":"133","author":"Cai","year":"2023","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0020","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.biomaterials.2017.08.008","article-title":"Reactive oxygen species-responsive polymeric nanoparticles for alleviating sepsis-induced acute liver injury in mice","volume":"144","author":"Chen","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/bs.mcb.2024.01.005_bb217","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00018.2001","article-title":"Free radicals in the physiological control of cell function","volume":"82","author":"Droge","year":"2002","journal-title":"Physiological Reviews"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0025","doi-asserted-by":"crossref","first-page":"1600171","DOI":"10.1002\/bies.201600171","article-title":"MAMs are attractive targets for bacterial repurposing of the host cell","volume":"39","author":"Escoll","year":"2016","journal-title":"BioEssays"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0030","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.freeradbiomed.2006.09.030","article-title":"Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function","volume":"42","author":"Fialkow","year":"2007","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0035","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global incidence and mortality of hospital-treated sepsis. Current estimates and limitations","volume":"193","author":"Fleischmann","year":"2016","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0040","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/ni.3509","article-title":"Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense","volume":"17","author":"Garaude","year":"2016","journal-title":"Nature Immunology"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0045","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1021\/acs.chemrev.5b00407","article-title":"Superoxide ion: Generation and chemical implications","volume":"116","author":"Hayyan","year":"2016","journal-title":"Chemical Reviews"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0050","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3390\/antiox10020313","article-title":"Functions of ROS in macrophages and antimicrobial immunity","volume":"10","author":"Herb","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0055","doi-asserted-by":"crossref","first-page":"eaar5926","DOI":"10.1126\/scisignal.aar5926","article-title":"Mitochondrial reactive oxygen species enable proinflammatory signaling through disulfide linkage of NEMO","volume":"12","author":"Herb","year":"2019","journal-title":"Science Signaling"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0060","article-title":"Inhibition of NADPH oxidase 2 (NOX2) prevents sepsis-induced cardiomyopathy by improving calcium handling and mitochondrial function","volume":"2","author":"Joseph","year":"2017","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0065","doi-asserted-by":"crossref","first-page":"L596","DOI":"10.1152\/ajplung.00328.2022","article-title":"p120-Catenin suppresses NLRP3 inflammasome activation in macrophages","volume":"324","author":"Kanmani","year":"2023","journal-title":"American Journal of Physiology. Lung Cellular and Molecular Physiology"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0070","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.biocel.2004.09.010","article-title":"Mitochondrial biogenesis and mitochondrial DNA maintenance of mammalian cells under oxidative stress","volume":"37","author":"Lee","year":"2005","journal-title":"International Journal of Biochemistry & Cell Biology"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0075","doi-asserted-by":"crossref","first-page":"8516","DOI":"10.1074\/jbc.M210432200","article-title":"Mitochondrial complex I inhibitor rotenone induces apoptosis through enhancing mitochondrial reactive oxygen species production","volume":"278","author":"Li","year":"2003","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0080","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.freeradbiomed.2008.09.003","article-title":"The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis","volume":"45","author":"Lowes","year":"2008","journal-title":"Free Radical Biology and Medicine"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0085","doi-asserted-by":"crossref","first-page":"31736","DOI":"10.1074\/jbc.M114.609396","article-title":"A role for stefin B (cystatin B) in inflammation and endotoxemia","volume":"289","author":"Maher","year":"2014","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0090","doi-asserted-by":"crossref","first-page":"5985209","DOI":"10.1155\/2017\/5985209","article-title":"Role of oxidative stress and mitochondrial dysfunction in sepsis and potential therapies","author":"Mantzarlis","year":"2017","journal-title":"Oxidative Medicine and Cellular Longevity"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0095","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.tim.2021.09.010","article-title":"Control of host mitochondria by bacterial pathogens","volume":"30","author":"Marchi","year":"2022","journal-title":"Trends in Microbiology"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0100","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1097\/01.CCM.0000174478.70338.03","article-title":"Outcome measures for clinical research in sepsis: A report of the 2nd Cambridge Colloquium of the International Sepsis Forum","volume":"33","author":"Marshall","year":"2005","journal-title":"Critical Care Medicine"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"key":"10.1016\/bs.mcb.2024.01.005_bb219","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1038\/nprot.2007.327","article-title":"Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy","volume":"2","author":"Mukhopadhyay","year":"2007","journal-title":"Nature Protocols"},{"key":"10.1016\/bs.mcb.2024.01.005_bb216","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4266\/acc.2018.00157","article-title":"Role of Mitochondrial oxidative stress in sepsis","volume":"33","author":"Nagar","year":"2018","journal-title":"Acute Critical Care"},{"key":"10.1016\/bs.mcb.2024.01.005_bb218","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ni.1980","article-title":"Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome","volume":"12","author":"Nakahira","year":"2011","journal-title":"Nature Immunology"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0110","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1186\/s13613-021-00893-7","article-title":"Energetic dysfunction in sepsis: A narrative review","volume":"11","author":"Preau","year":"2021","journal-title":"Annals of Intensive Care"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0115","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.intimp.2014.10.019","article-title":"Mitochondrial anti-oxidant protects IEX-1 deficient mice from organ damage during endotoxemia","volume":"23","author":"Ramsey","year":"2014","journal-title":"International Immunopharmacology"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0120","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cellular Signalling"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0125","doi-asserted-by":"crossref","DOI":"10.1111\/apha.13214","article-title":"Mitochondrial complex IV mutation increases reactive oxygen species production and reduces lifespan in aged mice","volume":"225","author":"Reichart","year":"2019","journal-title":"Acta Physiology"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0130","doi-asserted-by":"crossref","first-page":"15038","DOI":"10.1073\/pnas.0601945103","article-title":"Selective fluorescent imaging of superoxide in vivo using ethidium-based probes","volume":"103","author":"Robinson","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0135","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.cell.2013.03.022","article-title":"TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species","volume":"153","author":"Roca","year":"2013","journal-title":"Cell"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2019.08.004","article-title":"TNF induces pathogenic programmed macrophage necrosis in tuberculosis through a mitochondrial-lysosomal-endoplasmic reticulum circuit","volume":"178","author":"Roca","year":"2019","journal-title":"Cell"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0145","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3389\/fphys.2017.00428","article-title":"Role of mitochondrial reverse electron transport in ROS signaling: Potential roles in health and disease","volume":"8","author":"Scialo","year":"2017","journal-title":"Frontiers in Physiology"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0150","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008470","article-title":"Mitochondrial reactive oxygen species as major effectors of antimicrobial immunity","volume":"16","author":"Shekhova","year":"2020","journal-title":"PLoS Pathogens"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0155","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1093\/nar\/gkp100","article-title":"Oxidative stress induces degradation of mitochondrial DNA","volume":"37","author":"Shokolenko","year":"2009","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0160","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"Journal of the American Medical Association"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0165","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1101\/gad.1553007","article-title":"Nuclear receptor ERR\u03b1 and coactivator PGC-1\u03b2 are effectors of IFN-\u03b3-induced host defense","volume":"21","author":"Sonoda","year":"2007","journal-title":"Genes & Development"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0170","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.tcb.2020.01.006","article-title":"Mitochondrial functions in infection and immunity","volume":"30","author":"Tiku","year":"2020","journal-title":"Trends in Cell Biology"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0175","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1089\/ars.2019.7727","article-title":"Mitochondrial reactive oxygen species contribute to pathological inflammation during influenza A virus infection in mice","volume":"32","author":"To","year":"2020","journal-title":"Antioxidants & Redox Signaling"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0180","doi-asserted-by":"crossref","first-page":"A31","DOI":"10.1253\/circj.CJ-08-0014","article-title":"Oxidative stress and mitochondrial DNA damage in heart failure","volume":"72","author":"Tsutsui","year":"2008","journal-title":"Circulation Journal"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0185","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1097\/01.CCM.0000194725.48928.3A","article-title":"Sepsis in European intensive care units: Results of the SOAP study","volume":"34","author":"Vincent","year":"2006","journal-title":"Critical Care Medicine"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0190","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/978-1-4939-7598-3_32","article-title":"Measurement of reactive oxygen species (ROS) and mitochondrial ROS in AMPK knockout mice blood vessels","volume":"1732","author":"Wang","year":"2018","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/bs.mcb.2024.01.005_bb0195","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.4049\/jimmunol.1200860","article-title":"Activation of NLRP3 inflammasome in alveolar macrophages contributes to mechanical stretch-induced lung inflammation and injury","volume":"190","author":"Wu","year":"2013","journal-title":"Journal of Immunology"},{"key":"10.1016\/bs.mcb.2024.01.005_bb220","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"}],"container-title":["Methods in Cell Biology","Methods for Monitoring Mitochondrial Functions During Pathogen Infection"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X24000189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X24000189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T13:25:01Z","timestamp":1753363501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091679X24000189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9780323992190"],"references-count":43,"URL":"https:\/\/doi.org\/10.1016\/bs.mcb.2024.01.005","relation":{},"ISSN":["0091-679X"],"issn-type":[{"value":"0091-679X","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}