{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:52:57Z","timestamp":1762231977072,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier","isbn-type":[{"type":"print","value":"9780443222405"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1016\/bs.mcb.2024.04.004","type":"book-chapter","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T15:52:34Z","timestamp":1716565954000},"page":"89-108","source":"Crossref","is-referenced-by-count":0,"title":["Identifying therapeutic compounds for autosomal dominant optic atrophy (ADOA) through screening in the nematode C. elegans"],"prefix":"10.1016","member":"78","reference":[{"issue":"2","key":"10.1016\/bs.mcb.2024.04.004_bb0010","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/79944","article-title":"OPA1, encoding a dynamin-related GTPase, is mutated in autosomal dominant optic atrophy linked to chromosome 3q28","volume":"26","author":"Alexander","year":"2000","journal-title":"Nature Genetics"},{"issue":"1","key":"10.1016\/bs.mcb.2024.04.004_bb0015","doi-asserted-by":"crossref","first-page":"9403","DOI":"10.1038\/s41598-017-09651-x","article-title":"An automated compound screening for anti-aging effects on the function of C. elegans sensory neurons","volume":"7","author":"Bazopoulou","year":"2017","journal-title":"Scientific Reports"},{"issue":"10","key":"10.1016\/bs.mcb.2024.04.004_bb0020","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1007\/s00018-019-03024-5","article-title":"Disruption of mitochondrial dynamics affects behaviour and lifespan in Caenorhabditis elegans","volume":"76","author":"Byrne","year":"2019","journal-title":"Cellular and Molecular Life Sciences"},{"key":"10.1016\/bs.mcb.2024.04.004_bb0025","article-title":"OPA1 modulates mitochondrial ca(2+) uptake through ER-mitochondria coupling","volume":"9","author":"Cartes-Saavedra","year":"2021","journal-title":"Frontiers in Cell and Development Biology"},{"issue":"45","key":"10.1016\/bs.mcb.2024.04.004_bb0030","doi-asserted-by":"crossref","first-page":"15927","DOI":"10.1073\/pnas.0407043101","article-title":"OPA1 requires mitofusin 1 to promote mitochondrial fusion","volume":"101","author":"Cipolat","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/bs.mcb.2024.04.004_bb0035","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cell.2013.08.032","article-title":"Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency","volume":"155","author":"Cogliati","year":"2013","journal-title":"Cell"},{"issue":"12","key":"10.1016\/bs.mcb.2024.04.004_bb0040","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1007\/s00417-018-4153-z","article-title":"Mitochondrial pathophysiology beyond the retinal ganglion cell: Occipital GABA is decreased in autosomal dominant optic neuropathy","volume":"256","author":"d'Almeida","year":"2018","journal-title":"Graefe's Archive for Clinical and Experimental Ophthalmology"},{"key":"10.1016\/bs.mcb.2024.04.004_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.681326","article-title":"Dominant optic atrophy (DOA): Modeling the kaleidoscopic roles of OPA1 in mitochondrial homeostasis","volume":"12","author":"Del Dotto","year":"2021","journal-title":"Frontiers in Neurology"},{"issue":"2","key":"10.1016\/bs.mcb.2024.04.004_bb0050","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/79936","article-title":"Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy","volume":"26","author":"Delettre","year":"2000","journal-title":"Nature Genetics"},{"key":"10.1016\/bs.mcb.2024.04.004_bb0055","doi-asserted-by":"crossref","first-page":"4581909","DOI":"10.1155\/2021\/4581909","article-title":"Neuroinflammatory mechanisms of mitochondrial dysfunction and neurodegeneration in glaucoma","volume":"2021","author":"Duarte","year":"2021","journal-title":"Journal of Ophthalmology"},{"issue":"1","key":"10.1016\/bs.mcb.2024.04.004_bb0060","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cell.2006.06.025","article-title":"OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion","volume":"126","author":"Frezza","year":"2006","journal-title":"Cell"},{"issue":"2","key":"10.1016\/bs.mcb.2024.04.004_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.721","article-title":"Drug discovery: Insights from the invertebrate Caenorhabditis elegans","volume":"9","author":"Giunti","year":"2021","journal-title":"Pharmacology Research & Perspectives"},{"issue":"5","key":"10.1016\/bs.mcb.2024.04.004_bb0070","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1016\/0002-9394(79)90565-8","article-title":"A clinicopathologic study of autosomal dominant optic atrophy","volume":"88","author":"Johnston","year":"1979","journal-title":"American Journal of Ophthalmology"},{"key":"10.1016\/bs.mcb.2024.04.004_bb0075","first-page":"1","article-title":"GABA","author":"Jorgensen","year":"2005","journal-title":"WormBook"},{"issue":"2","key":"10.1016\/bs.mcb.2024.04.004_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000022","article-title":"The C. elegans Opa1 homologue EAT-3 is essential for resistance to free radicals","volume":"4","author":"Kanazawa","year":"2008","journal-title":"PLoS Genetics"},{"issue":"2","key":"10.1016\/bs.mcb.2024.04.004_bb0085","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/j.1755-3768.1983.tb01424.x","article-title":"Histopathology of eye, optic nerve and brain in a case of dominant optic atrophy","volume":"61","author":"Kjer","year":"1983","journal-title":"Acta Ophthalmologica"},{"issue":"2","key":"10.1016\/bs.mcb.2024.04.004_bb0090","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/cdd.2012.128","article-title":"Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity","volume":"20","author":"Kushnareva","year":"2013","journal-title":"Cell Death and Differentiation"},{"key":"10.1016\/bs.mcb.2024.04.004_bb0095","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1750-1172-7-46","article-title":"Dominant optic atrophy","volume":"7","author":"Lenaers","year":"2012","journal-title":"Orphanet Journal of Rare Diseases"},{"issue":"1","key":"10.1016\/bs.mcb.2024.04.004_bb0100","doi-asserted-by":"crossref","DOI":"10.1002\/cpet.35","article-title":"Working with worms: Caenorhabditis elegans as a model organism","volume":"19","author":"Meneely","year":"2019","journal-title":"Current Protocols Essential Laboratory Techniques"},{"issue":"2","key":"10.1016\/bs.mcb.2024.04.004_bb0105","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1167\/iovs.06-0845","article-title":"Reduction of oscillatory potentials and photopic negative response in patients with autosomal dominant optic atrophy with OPA1 mutations","volume":"48","author":"Miyata","year":"2007","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"10.1016\/bs.mcb.2024.04.004_bb0110","doi-asserted-by":"crossref","first-page":"13023","DOI":"10.1038\/ncomms13023","article-title":"Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model","volume":"7","author":"Mondal","year":"2016","journal-title":"Nature Communications"},{"issue":"4","key":"10.1016\/bs.mcb.2024.04.004_bb0115","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1534\/genetics.119.301506","article-title":"The Caenorhabditis elegans transgenic toolbox","volume":"212","author":"Nance","year":"2019","journal-title":"Genetics"},{"issue":"22","key":"10.1016\/bs.mcb.2024.04.004_bb0120","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.97152","article-title":"Neuroleptics as therapeutic compounds stabilizing neuromuscular transmission in amyotrophic lateral sclerosis","volume":"2","author":"Patten","year":"2017","journal-title":"JCI Insight"},{"issue":"4","key":"10.1016\/bs.mcb.2024.04.004_bb0125","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1083\/jcb.200905070","article-title":"The BCL-2-like protein CED-9 of C. elegans promotes FZO-1\/Mfn1,2- and EAT-3\/Opa1-dependent mitochondrial fusion","volume":"186","author":"Rolland","year":"2009","journal-title":"The Journal of Cell Biology"},{"issue":"4","key":"10.1016\/bs.mcb.2024.04.004_bb0130","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1002\/acn3.51026","article-title":"Idebenone increases chance of stabilization\/recovery of visual acuity in OPA1-dominant optic atrophy","volume":"7","author":"Romagnoli","year":"2020","journal-title":"Annals of Clinical Translational Neurology"},{"key":"10.1016\/bs.mcb.2024.04.004_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.784987","article-title":"The role of mitochondria in optic atrophy with autosomal inheritance","volume":"15","author":"Strachan","year":"2021","journal-title":"Frontiers in Neuroscience"},{"issue":"1","key":"10.1016\/bs.mcb.2024.04.004_bb0140","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41551-021-00819-5","article-title":"Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow","volume":"6","author":"Xie","year":"2022","journal-title":"Nature Biomedical Engineering"},{"issue":"8","key":"10.1016\/bs.mcb.2024.04.004_bb0145","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.ophtha.2009.12.038","article-title":"The prevalence and natural history of dominant optic atrophy due to OPA1 mutations","volume":"117","author":"Yu-Wai-Man","year":"2010","journal-title":"Ophthalmology"},{"issue":"Pt. 3","key":"10.1016\/bs.mcb.2024.04.004_bb0150","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1093\/brain\/awq007","article-title":"Multi-system neurological disease is common in patients with OPA1 mutations","volume":"133","author":"Yu-Wai-Man","year":"2010","journal-title":"Brain"},{"issue":"1","key":"10.1016\/bs.mcb.2024.04.004_bb0155","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1038\/s41467-020-17821-1","article-title":"Inhibition of autophagy curtails visual loss in a model of autosomal dominant optic atrophy","volume":"11","author":"Zaninello","year":"2020","journal-title":"Nature Communications"},{"issue":"1","key":"10.1016\/bs.mcb.2024.04.004_bb0160","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41418-021-00847-3","article-title":"Sustained intracellular calcium rise mediates neuronal mitophagy in models of autosomal dominant optic atrophy","volume":"29","author":"Zaninello","year":"2022","journal-title":"Cell Death and Differentiation"},{"issue":"1","key":"10.1016\/bs.mcb.2024.04.004_bb0165","doi-asserted-by":"crossref","first-page":"210","DOI":"10.3390\/ijms23010210","article-title":"Mitochondrial retinopathies","volume":"23","author":"Zeviani","year":"2021","journal-title":"International Journal of Molecular Sciences"}],"container-title":["Methods in Cell Biology","Animal Models of Disease - Part B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X24001419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X24001419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:48:33Z","timestamp":1762231713000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091679X24001419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9780443222405"],"references-count":32,"URL":"https:\/\/doi.org\/10.1016\/bs.mcb.2024.04.004","relation":{},"ISSN":["0091-679X"],"issn-type":[{"type":"print","value":"0091-679X"}],"subject":[],"published":{"date-parts":[[2024]]}}}