{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T23:18:11Z","timestamp":1788218291995,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier","isbn-type":[{"value":"9780443222443","type":"print"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004795","name":"Institut Universitaire de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015545","name":"Seerave Foundation","doi-asserted-by":"publisher","award":["18006"],"award-info":[{"award-number":["18006"]}],"id":[{"id":"10.13039\/100015545","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014599","name":"Mark Foundation For Cancer Research","doi-asserted-by":"publisher","award":["ANR-23-RHUS-0010"],"award-info":[{"award-number":["ANR-23-RHUS-0010"]}],"id":[{"id":"10.13039\/100014599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014599","name":"Mark Foundation For Cancer Research","doi-asserted-by":"publisher","award":["PAIR-Ob\\u00E9sit\\u00E9 INCa_1873"],"award-info":[{"award-number":["PAIR-Ob\\u00E9sit\\u00E9 INCa_1873"]}],"id":[{"id":"10.13039\/100014599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014599","name":"Mark Foundation For Cancer Research","doi-asserted-by":"publisher","award":["ANR-21-RHUS-0017"],"award-info":[{"award-number":["ANR-21-RHUS-0017"]}],"id":[{"id":"10.13039\/100014599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["101052444"],"award-info":[{"award-number":["101052444"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2021-ADG"],"award-info":[{"award-number":["ERC-2021-ADG"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007391","name":"Association pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007391","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014630","name":"Minist\u00e8re des Solidarit\u00e9s et de la Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014630","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016784","name":"Equipex","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006431","name":"Canc\u00e9rop\u00f4le Ile de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004100","name":"Labex","doi-asserted-by":"publisher","award":["ANR-18-IDEX-0001"],"award-info":[{"award-number":["ANR-18-IDEX-0001"]}],"id":[{"id":"10.13039\/501100004100","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["825410"],"award-info":[{"award-number":["825410"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-23-CE44\\u20130030"],"award-info":[{"award-number":["ANR-23-CE44\\u20130030"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-23-R4HC-0006 Ener-LIGHT"],"award-info":[{"award-number":["ANR-23-R4HC-0006 Ener-LIGHT"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-22-CE14\\u20130066"],"award-info":[{"award-number":["ANR-22-CE14\\u20130066"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["21-ESRE-0028"],"award-info":[{"award-number":["21-ESRE-0028"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/bs.mcb.2025.03.023","type":"book-chapter","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T15:51:01Z","timestamp":1747324261000},"page":"179-192","source":"Crossref","is-referenced-by-count":1,"title":["Orthotopic model of tongue cancer for the study of head and neck squamous cell carcinoma in mice"],"prefix":"10.1016","member":"78","reference":[{"issue":"19","key":"10.1016\/bs.mcb.2025.03.023_bib1","doi-asserted-by":"crossref","first-page":"4685","DOI":"10.3390\/cancers15194685","article-title":"Role of DNA methylation profiles as potential biomarkers and novel therapeutic targets in head and neck cancer","volume":"15","author":"Burkitt","year":"2023","journal-title":"Cancers"},{"issue":"10","key":"10.1016\/bs.mcb.2025.03.023_bib2","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1038\/s41416-023-02186-1","article-title":"Preclinical models in head and neck squamous cell carcinoma","volume":"128","author":"Chaves","year":"2023","journal-title":"British Journal of Cancer"},{"key":"10.1016\/bs.mcb.2025.03.023_bib3","article-title":"Restoring p53 function in head and neck squamous cell carcinoma to improve treatments","volume":"11","author":"de Bakker","year":"2021","journal-title":"Frontiers in Oncology"},{"issue":"9","key":"10.1016\/bs.mcb.2025.03.023_bib4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.21037\/atm.2016.03.34","article-title":"The emerging role of immunotherapy in head and neck squamous cell carcinoma (HNSCC): anti-tumor immunity and clinical applications","volume":"4","author":"Economopoulou","year":"2016","journal-title":"Annals of Translational Medicine"},{"issue":"10","key":"10.1016\/bs.mcb.2025.03.023_bib5","doi-asserted-by":"crossref","first-page":"915","DOI":"10.21037\/atm-20-6264","article-title":"Molecular landscape of head and neck cancer and implications for therapy","volume":"9","author":"Farah","year":"2021","journal-title":"Annals of Translational Medicine"},{"issue":"1","key":"10.1016\/bs.mcb.2025.03.023_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: New dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discovery"},{"issue":"9","key":"10.1016\/bs.mcb.2025.03.023_bib7","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/pmic.200900758","article-title":"Matrigel: A complex protein mixture required for optimal growth of cell culture","volume":"10","author":"Hughes","year":"2010","journal-title":"Proteomics"},{"key":"10.1016\/bs.mcb.2025.03.023_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/464720","article-title":"Genome stability pathways in head and neck cancers","volume":"2013","author":"Jenkins","year":"2013","journal-title":"International Journal of Genomics"},{"key":"10.1016\/bs.mcb.2025.03.023_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2022.979575","article-title":"Characterization of tumor immune microenvironment and cancer therapy for head and neck squamous cell carcinoma through identification of a genomic instability-related lncRNA prognostic signature","volume":"13","author":"Jing","year":"2022","journal-title":"Frontiers in Genetics"},{"issue":"1","key":"10.1016\/bs.mcb.2025.03.023_bib10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nature Reviews. Disease Primers"},{"key":"10.1016\/bs.mcb.2025.03.023_bib11","doi-asserted-by":"crossref","DOI":"10.1177\/15330338221150559","article-title":"Immunomodulatory therapy in head and neck squamous cell carcinoma: Recent advances and clinical prospects","volume":"22","author":"Khadela","year":"2023","journal-title":"Technology in Cancer Research & Treatment"},{"issue":"5","key":"10.1016\/bs.mcb.2025.03.023_bib12","first-page":"2733","article-title":"Oral mucosal carcinogenesis in SENCAR mice","volume":"22","author":"Kim","year":"2002","journal-title":"Anticancer Research"},{"issue":"4","key":"10.1016\/bs.mcb.2025.03.023_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/2472555219896999","article-title":"Maximizing the value of cancer drug screening in multicellular tumor spheroid cultures: A case study in five head and neck squamous cell carcinoma cell lines","volume":"25","author":"Kochanek","year":"2020","journal-title":"SLAS Discovery: Advancing Life Sciences R & D"},{"issue":"2","key":"10.1016\/bs.mcb.2025.03.023_bib14","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.anl.2023.08.006","article-title":"Translational research in head and neck cancer: Molecular and immunological updates","volume":"51","author":"Kumai","year":"2024","journal-title":"Auris, Nasus, Larynx"},{"issue":"40","key":"10.1016\/bs.mcb.2025.03.023_bib15","doi-asserted-by":"crossref","first-page":"66226","DOI":"10.18632\/oncotarget.11265","article-title":"The etiologic spectrum of head and neck squamous cell carcinoma in young patients","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/bs.mcb.2025.03.023_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.oraloncology.2022.106194","article-title":"Epigenetics: Promising journey so far but ways to go in head neck cancer","volume":"135","author":"Mali","year":"2022","journal-title":"Oral Oncology"},{"key":"10.1016\/bs.mcb.2025.03.023_bib17","article-title":"Dissecting the functions of cancer-associated fibroblasts to therapeutically target head and neck cancer microenvironment","volume":"161","author":"Prieto-Fernandez","year":"2023","journal-title":"Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie"},{"issue":"1","key":"10.1016\/bs.mcb.2025.03.023_bib18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.gendis.2014.07.002","article-title":"Unraveling the molecular genetics of head and neck cancer through genome-wide approaches","volume":"1","author":"Riaz","year":"2014","journal-title":"Genes & Diseases"},{"issue":"2","key":"10.1016\/bs.mcb.2025.03.023_bib19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1634\/theoncologist.2017-0527","article-title":"Immunotherapy for head and neck cancer in the era of exponentially increasing health care expenditure","volume":"23","author":"Santana-Davila","year":"2018","journal-title":"The Oncologist"},{"issue":"1","key":"10.1016\/bs.mcb.2025.03.023_bib20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.coms.2018.09.003","article-title":"Current concepts in chemotherapy for head and neck cancer","volume":"31","author":"Sindhu","year":"2019","journal-title":"Oral and Maxillofacial Surgery Clinics of North America"},{"issue":"10","key":"10.1016\/bs.mcb.2025.03.023_bib21","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.32604\/or.2024.052120","article-title":"Novel insights on oral squamous cell carcinoma management using long non-coding RNAs","volume":"32","author":"Sur","year":"2024","journal-title":"Oncology Research"},{"issue":"7","key":"10.1016\/bs.mcb.2025.03.023_bib22","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.cell.2024.02.009","article-title":"Embracing cancer complexity: Hallmarks of systemic disease","volume":"187","author":"Swanton","year":"2024","journal-title":"Cell"},{"key":"10.1016\/bs.mcb.2025.03.023_bib23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s41199-020-00056-4","article-title":"Preclinical models of head and neck squamous cell carcinoma for a basic understanding of cancer biology and its translation into efficient therapies","volume":"5","author":"Tinhofer","year":"2020","journal-title":"Cancers Head Neck"},{"key":"10.1016\/bs.mcb.2025.03.023_bib24","doi-asserted-by":"crossref","unstructured":"Treuting, P., & Dintzis, S. Comparative anatomy and histology: A mouse and human atlas. https:\/\/doi.org\/10.1016\/C2009-0-61166-1.","DOI":"10.1016\/C2009-0-61166-1"},{"issue":"2","key":"10.1016\/bs.mcb.2025.03.023_bib25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.canlet.2011.11.027","article-title":"Optimization of an orthotopic murine model of head and neck squamous cell carcinoma in fully immunocompetent mice-role of toll-like-receptor 4 expressed on host cells","volume":"317","author":"Vahle","year":"2012","journal-title":"Cancer Letters"},{"issue":"5","key":"10.1016\/bs.mcb.2025.03.023_bib26","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1158\/1940-6207.CAPR-09-0058","article-title":"Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer","volume":"2","author":"Vitale-Cross","year":"2009","journal-title":"Cancer Prevention Research"},{"key":"10.1016\/bs.mcb.2025.03.023_bib27","doi-asserted-by":"crossref","first-page":"1427725","DOI":"10.3389\/fonc.2024.1427725","article-title":"Histone modifications in head and neck squamous cell carcinom","volume":"14","author":"Wei","year":"2024","journal-title":"Frontiers in Oncology"},{"issue":"3","key":"10.1016\/bs.mcb.2025.03.023_bib28","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1159\/000494473","article-title":"The association and clinical significance of CDKN2A promoter methylation in head and neck squamous cell carcinoma: A meta-analysis","volume":"50","author":"Zhou","year":"2018","journal-title":"Cellular Physiology and Biochemistry"}],"container-title":["Methods in Cell Biology","Animal Models of Disease - Part D"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X25001049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X25001049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T04:49:31Z","timestamp":1762231771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091679X25001049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9780443222443"],"references-count":28,"URL":"https:\/\/doi.org\/10.1016\/bs.mcb.2025.03.023","relation":{},"ISSN":["0091-679X"],"issn-type":[{"value":"0091-679X","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]}}}