{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:32:19Z","timestamp":1787790739351,"version":"build-2784847793"},"reference-count":11,"publisher":"Elsevier","isbn-type":[{"value":"9780443295706","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.mcb.2025.12.006","type":"book-chapter","created":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T12:31:06Z","timestamp":1766233866000},"page":"25-39","source":"Crossref","is-referenced-by-count":1,"title":["Adeno-associated viral vector administration to the inner ear and phenotype evaluation in a mouse model of hearing loss"],"prefix":"10.1016","author":[{"given":"Sergio","family":"Isola","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Unzu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/bs.mcb.2025.12.006_bib1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/s41467-022-28969-3","article-title":"Choice of vector and surgical approach enables efficient cochlear gene transfer in nonhuman primate","volume":"13","author":"Andres-Mateos","year":"2022","journal-title":"Nature Communications"},{"key":"10.1016\/bs.mcb.2025.12.006_bib2","unstructured":"https:\/\/www.asgct.org\/global\/documents\/asgct-citeline-q1\u20132025-report.aspx (no date)."},{"key":"10.1016\/bs.mcb.2025.12.006_bib3","unstructured":"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/deafness-and-hearing-loss (no date)."},{"issue":"4","key":"10.1016\/bs.mcb.2025.12.006_bib4","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.ymthe.2023.02.001","article-title":"Advances in gene therapy hold promise for treating hereditary hearing loss","volume":"31","author":"Jiang","year":"2023","journal-title":"Molecular Therapy: the Journal of the American Society of Gene Therapy"},{"issue":"3","key":"10.1016\/bs.mcb.2025.12.006_bib5","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.3390\/jcm12031046","article-title":"Towards the clinical application of gene therapy for genetic inner ear diseases","volume":"12","author":"Lahlou","year":"2023","journal-title":"Journal of Clinical Medicine"},{"key":"10.1016\/bs.mcb.2025.12.006_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-025-03773-w","article-title":"AAV gene therapy for autosomal recessive deafness 9: A single-arm trial","author":"Qi","year":"2025","journal-title":"Nature Medicine"},{"issue":"3","key":"10.1016\/bs.mcb.2025.12.006_bib7","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ymthe.2022.12.018","article-title":"Cochlear transduction via cerebrospinal fluid delivery of AAV in non-human primates","volume":"31","author":"Ranum","year":"2023","journal-title":"Molecular Therapy: the Journal of the American Society of Gene Therapy"},{"issue":"9","key":"10.1016\/bs.mcb.2025.12.006_bib8","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1089\/hum.2016.053","article-title":"Identification of adeno-associated viral vectors that target neonatal and adult mammalian inner ear cell subtypes","volume":"27","author":"Shu","year":"2016","journal-title":"Human Gene Therapy"},{"issue":"5","key":"10.1016\/bs.mcb.2025.12.006_bib9","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41573-019-0012-9","article-title":"Adeno-associated virus vector as a platform for gene therapy delivery","volume":"18","author":"Wang","year":"2019","journal-title":"Nature Reviews. Drug Discovery"},{"issue":"7","key":"10.1016\/bs.mcb.2025.12.006_bib10","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1038\/s41591-024-03023-5","article-title":"Bilateral gene therapy in children with autosomal recessive deafness 9: single-arm trial results","volume":"30","author":"Wang","year":"2024","journal-title":"Nature Medicine"},{"issue":"1","key":"10.1016\/bs.mcb.2025.12.006_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3390\/biom13010038","article-title":"Approaches and vectors for efficient cochlear gene transfer in adult mouse models","volume":"13","author":"Zhao","year":"2022","journal-title":"Biomolecules"}],"container-title":["Methods in Cell Biology","Animal Models of Disease - Part E"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X25002481?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X25002481?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:57:31Z","timestamp":1782147451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091679X25002481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443295706"],"references-count":11,"URL":"https:\/\/doi.org\/10.1016\/bs.mcb.2025.12.006","relation":{},"ISSN":["0091-679X"],"issn-type":[{"value":"0091-679X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}