{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T23:28:55Z","timestamp":1777764535762,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier","isbn-type":[{"value":"9780443428654","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2022\\u201305058"],"award-info":[{"award-number":["RGPIN-2022\\u201305058"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["471011418"],"award-info":[{"award-number":["471011418"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR 353"],"award-info":[{"award-number":["TRR 353"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.mcb.2026.01.013","type":"book-chapter","created":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T12:22:54Z","timestamp":1771503774000},"page":"63-83","source":"Crossref","is-referenced-by-count":0,"title":["Implementation of the FENIX assay to assess the anti-ferroptotic properties of test compounds"],"prefix":"10.1016","author":[{"given":"Juliana A.","family":"H\u00fcther","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melodie","family":"Mallais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Rehm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek A.","family":"Pratt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/bs.mcb.2026.01.013_bib1","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1038\/ncb3064","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"16","author":"Angeli","year":"2014","journal-title":"Nature Cell Biology"},{"issue":"3","key":"10.1016\/bs.mcb.2026.01.013_bib2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/nrd1330","article-title":"Neurodegenerative diseases and oxidative stress","volume":"3","author":"Barnham","year":"2004","journal-title":"Nature Reviews. Drug Discovery"},{"issue":"4617","key":"10.1016\/bs.mcb.2026.01.013_bib3","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/1811199a0","article-title":"Antioxidant determinations by the use of a stable free radical","volume":"181","author":"Blois","year":"1958","journal-title":"Nature"},{"issue":"7","key":"10.1016\/bs.mcb.2026.01.013_bib4","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1021\/ar00127a001","article-title":"Vitamin E: Application of the principles of physical organic chemistry to the exploration of its structure and function","volume":"19","author":"Burton","year":"1986","journal-title":"Accounts of Chemical Research"},{"issue":"3","key":"10.1016\/bs.mcb.2026.01.013_bib5","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0891-5849(93)90027-R","article-title":"Oxygen-radical absorbance capacity assay for antioxidants","volume":"14","author":"Cao","year":"1993","journal-title":"Free Radical Biology and Medicine"},{"issue":"12","key":"10.1016\/bs.mcb.2026.01.013_bib6","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1038\/s41589-019-0408-1","article-title":"The chemical basis of ferroptosis","volume":"15","author":"Conrad","year":"2019","journal-title":"Nature Chemical Biology"},{"issue":"5","key":"10.1016\/bs.mcb.2026.01.013_bib7","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/nrd.2015.6","article-title":"Regulated necrosis: Disease relevance and therapeutic opportunities","volume":"15","author":"Conrad","year":"2016","journal-title":"Nature Reviews. Drug Discovery"},{"issue":"2","key":"10.1016\/bs.mcb.2026.01.013_bib8","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/0003-2697(91)90010-Q","article-title":"Iodometric measurement of lipid hydroperoxides in human plasma","volume":"193","author":"Cramer","year":"1991","journal-title":"Analytical Biochemistry"},{"issue":"7","key":"10.1016\/bs.mcb.2026.01.013_bib9","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.molcel.2023.03.005","article-title":"Ferroptosis: A flexible constellation of related biochemical mechanisms","volume":"83","author":"Dixon","year":"2023","journal-title":"Molecular Cell"},{"issue":"5","key":"10.1016\/bs.mcb.2026.01.013_bib10","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"issue":"7784","key":"10.1016\/bs.mcb.2026.01.013_bib11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41586-019-1707-0","article-title":"FSP1 is a glutathione-independent ferroptosis suppressor","volume":"575","author":"Doll","year":"2019","journal-title":"Nature"},{"issue":"1","key":"10.1016\/bs.mcb.2026.01.013_bib12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/nchembio.2239","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","volume":"13","author":"Doll","year":"2016","journal-title":"Nature Chemical Biology"},{"issue":"32","key":"10.1016\/bs.mcb.2026.01.013_bib13","doi-asserted-by":"crossref","first-page":"14706","DOI":"10.1021\/jacs.2c05252","article-title":"Intrinsic and Extrinsic Limitations to the Design and Optimization of Inhibitors of Lipid Peroxidation and Associated Cell Death","volume":"144","author":"Farmer","year":"2022","journal-title":"Journal of the American Chemical Society"},{"issue":"6809","key":"10.1016\/bs.mcb.2026.01.013_bib14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"issue":"10","key":"10.1016\/bs.mcb.2026.01.013_bib15","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1021\/cr200246d","article-title":"Lipoxygenase and leukotriene pathways: Biochemistry, biology, and roles in disease","volume":"111","author":"Haeggstr\u00f6m","year":"2011","journal-title":"Chemical Reviews"},{"issue":"81","key":"10.1016\/bs.mcb.2026.01.013_bib16","doi-asserted-by":"crossref","first-page":"10141","DOI":"10.1039\/c2cc35214a","article-title":"A versatile fluorescence approach to kinetic studies of hydrocarbon autoxidations and their inhibition by radical-trapping antioxidants","volume":"48","author":"Hanthorn","year":"2012","journal-title":"Chemical Communications"},{"issue":"13","key":"10.1016\/bs.mcb.2026.01.013_bib17","doi-asserted-by":"crossref","first-page":"7343","DOI":"10.1039\/D1CS00265A","article-title":"Autoxidation vs. antioxidants \u2013 The fight for forever","volume":"50","author":"Helberg","year":"2021","journal-title":"Chemical Society Reviews"},{"issue":"3","key":"10.1016\/bs.mcb.2026.01.013_bib18","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.chembiol.2018.11.016","article-title":"Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state","volume":"26","author":"Magtanong","year":"2019","journal-title":"Cell Chemical Biology"},{"issue":"3","key":"10.1016\/bs.mcb.2026.01.013_bib19","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1021\/acschembio.2c00897","article-title":"General approach to identify, assess, and characterize inhibitors of lipid peroxidation and associated cell death","volume":"18","author":"Mallais","year":"2023","journal-title":"ACS Chemical Biology"},{"issue":"10","key":"10.1016\/bs.mcb.2026.01.013_bib20","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1161\/CIRCRESAHA.110.224618","article-title":"Lipid oxidation and cardiovascular disease: Introduction to a review series","volume":"107","author":"McIntyre","year":"2010","journal-title":"Circulation Research"},{"issue":"11","key":"10.1016\/bs.mcb.2026.01.013_bib21","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1007\/s11745-001-0841-2","article-title":"Separation and identification of phospholipid peroxidation products","volume":"36","author":"Milne","year":"2001","journal-title":"Lipids"},{"key":"10.1016\/bs.mcb.2026.01.013_bib22","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41586-022-05022-3","article-title":"A non-canonical vitamin K cycle is a potent ferroptosis suppressor","volume":"608","author":"Mishima","year":"2022","journal-title":"Nature"},{"issue":"33","key":"10.1016\/bs.mcb.2026.01.013_bib23","doi-asserted-by":"crossref","first-page":"14331","DOI":"10.1021\/jacs.0c06379","article-title":"Potent ferroptosis inhibitors can catalyze the cross-dismutation of phospholipid-derived peroxyl radicals and hydroperoxyl radicals","volume":"142","author":"Poon","year":"2020","journal-title":"Journal of the American Chemical Society"},{"issue":"9\u201310","key":"10.1016\/bs.mcb.2026.01.013_bib24","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1016\/S0891-5849(98)00315-3","article-title":"Antioxidant activity applying an improved ABTS radical cation decolorization assay","volume":"26","author":"Re","year":"1999","journal-title":"Free Radical Biology And Medicine"},{"issue":"11","key":"10.1016\/bs.mcb.2026.01.013_bib25","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1016\/j.chembiol.2019.09.007","article-title":"Beyond DPPH: Use of fluorescence-enabled inhibited autoxidation to predict oxidative cell death rescue","volume":"26","author":"Shah","year":"2019","journal-title":"Cell Chemical Biology"},{"issue":"12","key":"10.1016\/bs.mcb.2026.01.013_bib26","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s41589-020-0613-y","article-title":"Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers","volume":"16","author":"Soula","year":"2020","journal-title":"Nature Chemical Biology"},{"issue":"10","key":"10.1016\/bs.mcb.2026.01.013_bib27","doi-asserted-by":"crossref","first-page":"5944","DOI":"10.1021\/cr200084z","article-title":"Free radical lipid peroxidation: Mechanisms and analysis","volume":"111","author":"Yin","year":"2011","journal-title":"Chemical Reviews"},{"issue":"6","key":"10.1016\/bs.mcb.2026.01.013_bib28","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1021\/acs.joc.7b00152","article-title":"Lipid peroxidation: Kinetics, mechanisms, and products","volume":"82","author":"Zielinski","year":"2017","journal-title":"The Journal of Organic Chemistry"},{"issue":"3","key":"10.1016\/bs.mcb.2026.01.013_bib29","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1021\/acscentsci.7b00028","article-title":"On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death","volume":"3","author":"Zilka","year":"2017","journal-title":"ACS Central Science"}],"container-title":["Methods in Cell Biology","Cell Death - Part A"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X26000130?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X26000130?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T15:05:56Z","timestamp":1777475156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091679X26000130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443428654"],"references-count":29,"URL":"https:\/\/doi.org\/10.1016\/bs.mcb.2026.01.013","relation":{},"ISSN":["0091-679X"],"issn-type":[{"value":"0091-679X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}