{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T21:06:02Z","timestamp":1779483962048,"version":"3.53.1"},"reference-count":12,"publisher":"Elsevier","isbn-type":[{"value":"9780443431203","type":"print"}],"license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["25023"],"award-info":[{"award-number":["25023"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["30664"],"award-info":[{"award-number":["30664"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 30453"],"award-info":[{"award-number":["IG 30453"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","award":["IG 2020"],"award-info":[{"award-number":["IG 2020"]}],"id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020581","name":"Fondazione AIRC per la ricerca sul cancro ETS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020581","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2018\\u201312366714"],"award-info":[{"award-number":["RF-2018\\u201312366714"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["5M-2022\\u201323685338"],"award-info":[{"award-number":["5M-2022\\u201323685338"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["J53D23001030006"],"award-info":[{"award-number":["J53D23001030006"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["CUP D53D23002010006"],"award-info":[{"award-number":["CUP D53D23002010006"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["PNRR-MCNT2\\u20132023-12378122"],"award-info":[{"award-number":["PNRR-MCNT2\\u20132023-12378122"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["C43C23000880006"],"award-info":[{"award-number":["C43C23000880006"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["2023-12378122 CUP J43C23000900006"],"award-info":[{"award-number":["2023-12378122 CUP J43C23000900006"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["5\\u2009\\u00D7\\u20091000"],"award-info":[{"award-number":["5\\u2009\\u00D7\\u20091000"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/bs.mcb.2026.01.027","type":"book-chapter","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T12:30:47Z","timestamp":1771590647000},"page":"155-178","source":"Crossref","is-referenced-by-count":0,"title":["Analyzing the effect of NK cells on in-vivo models of tumor dissemination by digital pathology and flow cytometry"],"prefix":"10.1016","author":[{"given":"Paola","family":"Orecchia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simonetta","family":"Astigiano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Delli Zotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Piombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Martini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Pigozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Carrega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Ferlazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Parodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/bs.mcb.2026.01.027_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: Open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Scientific Reports"},{"issue":"1","key":"10.1016\/bs.mcb.2026.01.027_bib2","article-title":"Human NK cells and cancer","volume":"13","author":"Cantoni","year":"2024","journal-title":"Oncoimmunology, 16"},{"issue":"5","key":"10.1016\/bs.mcb.2026.01.027_bib3","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.immuni.2017.10.008","article-title":"The broad spectrum of human natural killer cell diversity","volume":"47","author":"Freud","year":"2017","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/bs.mcb.2026.01.027_bib4","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-010205","article-title":"CD56bright cytokine-induced memory-like NK cells and NK-cell engagers synergize against non-small cell lung cancer cancer-stem cells","volume":"13","author":"Guevara Lopez","year":"2025","journal-title":"Journal for Immunotherapy of Cancer"},{"key":"10.1016\/bs.mcb.2026.01.027_bib5","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.76269","article-title":"Functional visualization of NK cell-mediated killing of metastatic single tumor cells","volume":"11","author":"Ichise","year":"2022","journal-title":"Elife"},{"key":"10.1016\/bs.mcb.2026.01.027_bib6","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/978-1-0716-1258-3_4","article-title":"A murine bone metastasis model using caudal artery injection and bioluminescence imaging","volume":"2274","author":"Kuchimaru","year":"2021","journal-title":"Methods in Molecular Biology"},{"key":"10.1016\/bs.mcb.2026.01.027_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1209237","article-title":"Murine models to study human NK cells in human solid tumors","volume":"14","author":"Parodi","year":"2023","journal-title":"Frontiers in Immunology"},{"issue":"3","key":"10.1016\/bs.mcb.2026.01.027_bib8","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-007895","article-title":"Hybrid epithelial-mesenchymal status of lung cancer dictates metastatic success through differential interaction with NK cells","volume":"12","author":"Parodi","year":"2024","journal-title":"Journal for Immunotherapy of Cancer"},{"issue":"8","key":"10.1016\/bs.mcb.2026.01.027_bib9","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1038\/s41590-024-01883-0","article-title":"High-dimensional single-cell analysis of human natural killer cell heterogeneity","volume":"25","author":"Rebuffet","year":"2024","journal-title":"Nature Immunology"},{"key":"10.1016\/bs.mcb.2026.01.027_bib10","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1126\/science.1068440","article-title":"Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplants","volume":"295","author":"Ruggeri","year":"2002","journal-title":"Science"},{"issue":"8","key":"10.1016\/bs.mcb.2026.01.027_bib11","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.cell.2023.03.006","article-title":"Immune checkpoint therapy-current perspectives and future directions","volume":"186","author":"Sharma","year":"2023","journal-title":"Cell"},{"issue":"10","key":"10.1016\/bs.mcb.2026.01.027_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/jcm8101702","article-title":"NK cell-based immunotherapy for hematological malignancies","volume":"8","author":"Sivori","year":"2019","journal-title":"Journal of Clinical Medicine"}],"container-title":["Methods in Cell Biology","Advanced Methodologies to Study and Enhance Cellular Cytotoxicity Against Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X26000373?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0091679X26000373?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T20:26:06Z","timestamp":1779481566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0091679X26000373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"ISBN":["9780443431203"],"references-count":12,"URL":"https:\/\/doi.org\/10.1016\/bs.mcb.2026.01.027","relation":{},"ISSN":["0091-679X"],"issn-type":[{"value":"0091-679X","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]}}}