{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:36:44Z","timestamp":1767987404563,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier","isbn-type":[{"value":"9780128168318","type":"print"}],"license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019]]},"DOI":"10.1016\/bs.mie.2019.05.027","type":"book-chapter","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T02:34:28Z","timestamp":1560393268000},"page":"291-314","source":"Crossref","is-referenced-by-count":4,"title":["A fluorescent aminosugar to rapidly screen and study RNA binders"],"prefix":"10.1016","author":[{"given":"Nihar","family":"Ranjan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dev P.","family":"Arya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/bs.mie.2019.05.027_bb0010","series-title":"Aminoglycoside antibiotics: From chemical biology to drug discovery","author":"Arya","year":"2007"},{"key":"10.1016\/bs.mie.2019.05.027_bb0015","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3762\/bjoc.14.93","article-title":"An overview of recent advances in duplex DNA recognition by small molecules","volume":"14","author":"Bhaduri","year":"2018","journal-title":"Beilstein Journal of Organic Chemistry"},{"key":"10.1016\/bs.mie.2019.05.027_bb0020","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.1021\/ja010041a","article-title":"A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity","volume":"123","author":"Boger","year":"2001","journal-title":"Journal of the American Chemical Society"},{"issue":"2","key":"10.1016\/bs.mie.2019.05.027_bb0025","first-page":"162","article-title":"Advances in the analysis of isothermal titration calorimetry data for ligand-DNA interactions","volume":"42","author":"Buurma","year":"2007","journal-title":"Methods (Oxford, United Kingdom)"},{"key":"10.1016\/bs.mie.2019.05.027_bb0030","series-title":"The RNA world Cold","author":"Cech","year":"1999"},{"issue":"3","key":"10.1016\/bs.mie.2019.05.027_bb0035","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1021\/acsinfecdis.6b00176","article-title":"Antimicrobial activity, AME resistance, and A-site binding studies of anthraquinone-neomycin conjugates","volume":"3","author":"Degtyareva","year":"2018","journal-title":"ACS Infectious Diseases"},{"issue":"7","key":"10.1016\/bs.mie.2019.05.027_bb0040","doi-asserted-by":"crossref","first-page":"E41","DOI":"10.1093\/nar\/gky019","article-title":"A rapid fluorescent indicator displacement assay and principal component\/cluster data analysis for determination of ligand\u2013nucleic acid structural selectivity","volume":"46","author":"Del Villar-Guerra","year":"2018","journal-title":"Nucleic Acids Research"},{"issue":"7426","key":"10.1016\/bs.mie.2019.05.027_bb0045","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/nature11498","article-title":"Visualizing transient low-populated structures of RNA","volume":"491","author":"Dethoff","year":"2012","journal-title":"Nature"},{"key":"10.1016\/bs.mie.2019.05.027_bb0050","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0076-6879(01)40418-6","article-title":"Linear and circular dichroism of drug-nucleic acid complexes","volume":"340","author":"Eriksson","year":"2001","journal-title":"Methods in Enzymology"},{"key":"10.1016\/bs.mie.2019.05.027_bb0055","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1006\/jmbi.1997.1552","article-title":"Binding of neomycin-class aminoglycoside antibiotics to the A-site of 16 S rRNA","volume":"277","author":"Fourmy","year":"1998","journal-title":"Journal of Molecular Biology"},{"issue":"12","key":"10.1016\/bs.mie.2019.05.027_bb0060","doi-asserted-by":"crossref","first-page":"3166","DOI":"10.1038\/nprot.2007.475","article-title":"Circular dichroism to determine binding mode and affinity of ligand-DNA interactions","volume":"2","author":"Garbett","year":"2007","journal-title":"Nature Protocols"},{"issue":"7","key":"10.1016\/bs.mie.2019.05.027_bb0065","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1039\/C8MD00092A","article-title":"Targeting miRNA by tunable small molecule binders: Peptidic aminosugar mediated interference in miR-21 biogenesis reverts epithelial to mesenchymal transition","volume":"9","author":"Ghosh","year":"2018","journal-title":"MedChemComm"},{"issue":"5","key":"10.1016\/bs.mie.2019.05.027_bb0070","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1021\/cb5010367","article-title":"Rapid synthesis, RNA binding, and antibacterial screening of a peptidic-aminosugar (Pa) library","volume":"10","author":"Jiang","year":"2015","journal-title":"ACS Chemical Biology"},{"issue":"1","key":"10.1016\/bs.mie.2019.05.027_bb0075","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1039\/C5MD00427F","article-title":"Arginine-linked neomycin B dimers: Synthesis, rRNA binding, and resistance enzyme activity","volume":"7","author":"Jin","year":"2016","journal-title":"Medchemcomm"},{"issue":"24","key":"10.1016\/bs.mie.2019.05.027_bb0080","doi-asserted-by":"crossref","first-page":"7695","DOI":"10.1021\/bi020130f","article-title":"Thermodynamics of aminoglycoside\u2014rRNA recognition: The binding of neomycin-class aminoglycosides to the a site of 16s rRNA","volume":"41","author":"Kaul","year":"2002","journal-title":"Biochemistry"},{"issue":"10","key":"10.1016\/bs.mie.2019.05.027_bb0085","doi-asserted-by":"crossref","first-page":"4717","DOI":"10.1128\/AAC.00671-13","article-title":"Characterization of ribosomal binding and antibacterial activities using two orthogonal high throughput capable screens","volume":"57","author":"King","year":"2013","journal-title":"Antimicrobial Agents and Chemotherapy"},{"issue":"33","key":"10.1016\/bs.mie.2019.05.027_bb0090","doi-asserted-by":"crossref","first-page":"4418","DOI":"10.1016\/j.tet.2018.07.012","article-title":"Rapid solid-phase syntheses of a peptidic-aminoglycoside library","volume":"74","author":"Kukielski","year":"2018","journal-title":"Tetrahedron"},{"key":"10.1016\/bs.mie.2019.05.027_bb0095","doi-asserted-by":"crossref","first-page":"6775","DOI":"10.1021\/ac070907g","article-title":"Tuning the pKa of fluorescein to optimize binding assays","volume":"79","author":"Lavis","year":"2007","journal-title":"Analytical Chemistry"},{"issue":"5","key":"10.1016\/bs.mie.2019.05.027_bb0100","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1006\/jmbi.2000.4420","article-title":"Structural origins of aminoglycoside specificity for prokaryotic ribosomes","volume":"306","author":"Lynch","year":"2001","journal-title":"Journal of Molecular Biology"},{"issue":"13","key":"10.1016\/bs.mie.2019.05.027_bb0105","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.1021\/acs.jmedchem.5b01835","article-title":"Quadruplex nucleic acids as novel therapeutic targets","volume":"59","author":"Neidle","year":"2016","journal-title":"Journal of Medicinal Chemistry"},{"key":"10.1016\/bs.mie.2019.05.027_bb0110","series-title":"Linear dichroism and circular dichroism","author":"Norden","year":"2010"},{"issue":"13","key":"10.1016\/bs.mie.2019.05.027_bb0115","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1021\/acs.biochem.6b00055","article-title":"RNA G-quadruplex invasion and translation inhibition by antisense gamma-peptide nucleic acid oligomers","volume":"55","author":"Oyaghire","year":"2016","journal-title":"Biochemistry"},{"issue":"7","key":"10.1016\/bs.mie.2019.05.027_bb0120","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1039\/C8OB02467G","article-title":"Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA","volume":"17","author":"Patwardhan","year":"2018","journal-title":"Organic & Biomolecular Chemistry"},{"issue":"24","key":"10.1016\/bs.mie.2019.05.027_bb0125","doi-asserted-by":"crossref","first-page":"5989","DOI":"10.1016\/j.bmcl.2016.10.076","article-title":"Linker dependent intercalation of bisbenzimidazole-aminosugars in an RNA duplex; selectivity in RNA vs. DNA binding","volume":"26","author":"Ranjan","year":"2016","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"issue":"49","key":"10.1016\/bs.mie.2019.05.027_bb0130","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.1021\/bi992070s","article-title":"Sequence and structural selectivity of nucleic acid binding ligands","volume":"38","author":"Ren","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/bs.mie.2019.05.027_bb0135","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/(SICI)1097-0282(199812)46:7<445::AID-BIP2>3.0.CO;2-5","article-title":"Characterization of fluorescein-oligonucleotide conjugates and measurement of local electrostatic potential","volume":"46","author":"Sjoback","year":"1998","journal-title":"Biopolymers"},{"key":"10.1016\/bs.mie.2019.05.027_bb0140","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1021\/ar030113y","article-title":"A fluorescent intercalator displacement assay for establishing DNA binding selectivity and affinity","volume":"37","author":"Tse","year":"2004","journal-title":"Accounts of Chemical Research"},{"issue":"48","key":"10.1016\/bs.mie.2019.05.027_bb0145","doi-asserted-by":"crossref","first-page":"14859","DOI":"10.1021\/ja036166s","article-title":"On the value of c: Can low affinity systems be studied by isothermal titration calorimetry?","volume":"125","author":"Turnbull","year":"2003","journal-title":"Journal of the American Chemical Society"},{"issue":"4","key":"10.1016\/bs.mie.2019.05.027_bb0150","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.bmc.2016.11.003","article-title":"Probing A-form DNA: A fluorescent aminosugar probe and dual recognition by anthraquinone-neomycin conjugates","volume":"25","author":"Watkins","year":"2017","journal-title":"Bioorganic & Medicinal Chemistry"},{"issue":"12","key":"10.1016\/bs.mie.2019.05.027_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144251","article-title":"A Ph sensitive high-throughput assay for miRNA binding of a peptide-aminoglycoside (Pa) library","volume":"10","author":"Watkins","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/bs.mie.2019.05.027_bb0160","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ab.2012.12.003","article-title":"A fluorescence-based screen for ribosome binding antibiotics","volume":"434","author":"Watkins","year":"2013","journal-title":"Analytical Biochemistry"},{"issue":"7","key":"10.1016\/bs.mie.2019.05.027_bb0165","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1016\/j.bmc.2014.02.003","article-title":"Recognition of RNA duplex by a neomycin-hoechst 33258 conjugate","volume":"22","author":"Willis","year":"2014","journal-title":"Bioorganic & Medicinal Chemistry"},{"issue":"42","key":"10.1016\/bs.mie.2019.05.027_bb0170","doi-asserted-by":"crossref","first-page":"9088","DOI":"10.1021\/bi201077h","article-title":"Thermodynamics of nucleic acid \u201cshape readout\u201d by an aminosugar","volume":"50","author":"Xi","year":"2011","journal-title":"Biochemistry"}],"container-title":["Methods in Enzymology","RNA Recognition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0076687919301867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0076687919301867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,22]],"date-time":"2019-06-22T17:33:08Z","timestamp":1561224788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0076687919301867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"ISBN":["9780128168318"],"references-count":33,"URL":"https:\/\/doi.org\/10.1016\/bs.mie.2019.05.027","relation":{},"ISSN":["0076-6879"],"issn-type":[{"value":"0076-6879","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]}}}